diff --git a/Yesod/Persist/Core.hs b/Yesod/Persist/Core.hs
--- a/Yesod/Persist/Core.hs
+++ b/Yesod/Persist/Core.hs
@@ -1,3 +1,4 @@
+{-# LANGUAGE ConstraintKinds #-}
 {-# LANGUAGE TypeFamilies #-}
 {-# LANGUAGE CPP #-}
 {-# LANGUAGE FlexibleContexts #-}
@@ -20,7 +21,7 @@
     ) where
 
 import Database.Persist
-import Control.Monad.Trans.Reader (ReaderT, runReaderT)
+import Control.Monad.Trans.Reader (ReaderT, runReaderT, withReaderT)
 
 import Yesod.Core
 import Data.Conduit
@@ -80,12 +81,18 @@
 -- | Helper for implementing 'getDBRunner'.
 --
 -- Since 1.2.0
+#if MIN_VERSION_persistent(2,5,0)
+defaultGetDBRunner :: (SQL.IsSqlBackend backend, YesodPersistBackend site ~ backend)
+                   => (site -> Pool backend)
+                   -> HandlerT site IO (DBRunner site, HandlerT site IO ())
+#else
 defaultGetDBRunner :: YesodPersistBackend site ~ SQL.SqlBackend
                    => (site -> Pool SQL.SqlBackend)
                    -> HandlerT site IO (DBRunner site, HandlerT site IO ())
+#endif
 defaultGetDBRunner getPool = do
     pool <- fmap getPool getYesod
-    let withPrep conn f = f conn (SQL.connPrepare conn)
+    let withPrep conn f = f (persistBackend conn) (SQL.connPrepare $ persistBackend conn)
     (relKey, (conn, local)) <- allocate
         (do
             (conn, local) <- takeResource pool
@@ -124,9 +131,15 @@
 respondSourceDB ctype = respondSource ctype . runDBSource
 
 -- | Get the given entity by ID, or return a 404 not found if it doesn't exist.
+#if MIN_VERSION_persistent(2,5,0)
+get404 :: (MonadIO m, PersistStore backend, PersistRecordBackend val backend)
+       => Key val
+       -> ReaderT backend m val
+#else
 get404 :: (MonadIO m, PersistStore (PersistEntityBackend val), PersistEntity val)
        => Key val
        -> ReaderT (PersistEntityBackend val) m val
+#endif
 get404 key = do
     mres <- get key
     case mres of
@@ -135,9 +148,15 @@
 
 -- | Get the given entity by unique key, or return a 404 not found if it doesn't
 --   exist.
+#if MIN_VERSION_persistent(2,5,0)
+getBy404 :: (PersistUnique backend, PersistRecordBackend val backend, MonadIO m)
+         => Unique val
+         -> ReaderT backend m (Entity val)
+#else
 getBy404 :: (PersistUnique (PersistEntityBackend val), PersistEntity val, MonadIO m)
          => Unique val
          -> ReaderT (PersistEntityBackend val) m (Entity val)
+#endif
 getBy404 key = do
     mres <- getBy key
     case mres of
diff --git a/yesod-persistent.cabal b/yesod-persistent.cabal
--- a/yesod-persistent.cabal
+++ b/yesod-persistent.cabal
@@ -1,5 +1,5 @@
 name:            yesod-persistent
-version:         1.4.0.4
+version:         1.4.0.5
 license:         MIT
 license-file:    LICENSE
 author:          Michael Snoyman <michael@snoyman.com>
@@ -16,8 +16,8 @@
 library
     build-depends:   base                      >= 4        && < 5
                    , yesod-core                >= 1.4.0    && < 1.5
-                   , persistent                >= 2.1      && < 2.3
-                   , persistent-template       >= 2.1      && < 2.2
+                   , persistent                >= 2.1      && < 2.6
+                   , persistent-template       >= 2.1      && < 2.6
                    , transformers              >= 0.2.2
                    , blaze-builder
                    , conduit