diff --git a/compiler/GHC/ByteCode/Asm.hs b/compiler/GHC/ByteCode/Asm.hs
--- a/compiler/GHC/ByteCode/Asm.hs
+++ b/compiler/GHC/ByteCode/Asm.hs
@@ -27,7 +27,6 @@
 import GHC.Types.Name
 import GHC.Types.Name.Set
 import GHC.Types.Literal
-import GHC.Types.Unique
 import GHC.Types.Unique.DSet
 
 import GHC.Utils.Outputable
@@ -518,11 +517,11 @@
   CCALL off m_addr i       -> do np <- addr m_addr
                                  emit bci_CCALL [wOp off, Op np, SmallOp i]
   PRIMCALL                 -> emit bci_PRIMCALL []
-  BRK_FUN index uniq cc    -> do p1 <- ptr BCOPtrBreakArray
-                                 q <- int (getKey uniq)
+  BRK_FUN index mod cc     -> do p1 <- ptr BCOPtrBreakArray
+                                 m <- addr mod
                                  np <- addr cc
                                  emit bci_BRK_FUN [Op p1, SmallOp index,
-                                                   Op q, Op np]
+                                                   Op m, Op np]
 
   where
     literal (LitLabel fs (Just sz) _)
diff --git a/compiler/GHC/ByteCode/Instr.hs b/compiler/GHC/ByteCode/Instr.hs
--- a/compiler/GHC/ByteCode/Instr.hs
+++ b/compiler/GHC/ByteCode/Instr.hs
@@ -19,7 +19,6 @@
 import GHC.StgToCmm.Layout     ( ArgRep(..) )
 import GHC.Utils.Outputable
 import GHC.Types.Name
-import GHC.Types.Unique
 import GHC.Types.Literal
 import GHC.Core.DataCon
 import GHC.Builtin.PrimOps
@@ -31,6 +30,7 @@
 import GHC.Stack.CCS (CostCentre)
 
 import GHC.Stg.Syntax
+import Language.Haskell.Syntax.Module.Name (ModuleName)
 
 -- ----------------------------------------------------------------------------
 -- Bytecode instructions
@@ -205,7 +205,7 @@
                    -- Note [unboxed tuple bytecodes and tuple_BCO] in GHC.StgToByteCode
 
    -- Breakpoints
-   | BRK_FUN         !Word16 Unique (RemotePtr CostCentre)
+   | BRK_FUN         !Word16 (RemotePtr ModuleName) (RemotePtr CostCentre)
 
 -- -----------------------------------------------------------------------------
 -- Printing bytecode instructions
@@ -356,11 +356,7 @@
    ppr ENTER                 = text "ENTER"
    ppr (RETURN pk)           = text "RETURN  " <+> ppr pk
    ppr (RETURN_TUPLE)        = text "RETURN_TUPLE"
-   ppr (BRK_FUN index uniq _cc) = text "BRK_FUN" <+> ppr index <+> mb_uniq <+> text "<cc>"
-     where mb_uniq = sdocOption sdocSuppressUniques $ \case
-             True  -> text "<uniq>"
-             False -> ppr uniq
-
+   ppr (BRK_FUN index _mod_name _cc) = text "BRK_FUN" <+> ppr index <+> text "<module>" <+> text "<cc>"
 
 
 -- -----------------------------------------------------------------------------
diff --git a/compiler/GHC/Cmm/CommonBlockElim.hs b/compiler/GHC/Cmm/CommonBlockElim.hs
--- a/compiler/GHC/Cmm/CommonBlockElim.hs
+++ b/compiler/GHC/Cmm/CommonBlockElim.hs
@@ -26,6 +26,7 @@
 import qualified GHC.Data.TrieMap as TM
 import GHC.Types.Unique.FM
 import GHC.Types.Unique
+import GHC.Utils.Word64 (truncateWord64ToWord32)
 import Control.Arrow (first, second)
 import Data.List.NonEmpty (NonEmpty (..))
 import qualified Data.List.NonEmpty as NE
@@ -182,8 +183,10 @@
 
         cvt = fromInteger . toInteger
 
+        -- Since we are hashing, we can savely downcast Word64 to Word32 here.
+        -- Although a different hashing function may be more effective.
         hash_unique :: Uniquable a => a -> Word32
-        hash_unique = cvt . getKey . getUnique
+        hash_unique = truncateWord64ToWord32 . getKey . getUnique
 
 -- | Ignore these node types for equality
 dont_care :: CmmNode O x -> Bool
diff --git a/compiler/GHC/Cmm/Dominators.hs b/compiler/GHC/Cmm/Dominators.hs
--- a/compiler/GHC/Cmm/Dominators.hs
+++ b/compiler/GHC/Cmm/Dominators.hs
@@ -26,8 +26,7 @@
 import Data.Foldable()
 import qualified Data.Tree as Tree
 
-import qualified Data.IntMap.Strict as IM
-import qualified Data.IntSet as IS
+import Data.Word
 
 import qualified GHC.CmmToAsm.CFG.Dominators as LT
 
@@ -41,6 +40,9 @@
 import GHC.Utils.Outputable( Outputable(..), text, int, hcat, (<+>))
 import GHC.Utils.Misc
 import GHC.Utils.Panic
+import GHC.Utils.Word64 (intToWord64)
+import qualified GHC.Data.Word64Map as WM
+import qualified GHC.Data.Word64Set as WS
 
 
 -- | =Dominator sets
@@ -129,33 +131,37 @@
 -- The implementation uses the Lengauer-Tarjan algorithm from the x86
 -- back end.
 
+-- Technically, we do not need Word64 here, however the dominators code
+-- has to accomodate Word64 for other uses.
+
 graphWithDominators g = GraphWithDominators (reachable rpblocks g) dmap rpmap
       where rpblocks = revPostorderFrom (graphMap g) (g_entry g)
             rplabels' = map entryLabel rpblocks
-            rplabels :: Array Int Label
+            rplabels :: Array Word64 Label
             rplabels = listArray bounds rplabels'
 
             rpmap :: LabelMap RPNum
             rpmap = mapFromList $ zipWith kvpair rpblocks [0..]
               where kvpair block i = (entryLabel block, RPNum i)
 
-            labelIndex :: Label -> Int
+            labelIndex :: Label -> Word64
             labelIndex = flip findLabelIn imap
-              where imap :: LabelMap Int
+              where imap :: LabelMap Word64
                     imap = mapFromList $ zip rplabels' [0..]
             blockIndex = labelIndex . entryLabel
 
-            bounds = (0, length rpblocks - 1)
+            bounds :: (Word64, Word64)
+            bounds = (0, intToWord64 (length rpblocks - 1))
 
             ltGraph :: [Block node C C] -> LT.Graph
-            ltGraph [] = IM.empty
+            ltGraph [] = WM.empty
             ltGraph (block:blocks) =
-                IM.insert
+                WM.insert
                       (blockIndex block)
-                      (IS.fromList $ map labelIndex $ successors block)
+                      (WS.fromList $ map labelIndex $ successors block)
                       (ltGraph blocks)
 
-            idom_array :: Array Int LT.Node
+            idom_array :: Array Word64 LT.Node
             idom_array = array bounds $ LT.idom (0, ltGraph rpblocks)
 
             domSet 0 = EntryNode
diff --git a/compiler/GHC/Cmm/LRegSet.hs b/compiler/GHC/Cmm/LRegSet.hs
--- a/compiler/GHC/Cmm/LRegSet.hs
+++ b/compiler/GHC/Cmm/LRegSet.hs
@@ -20,34 +20,35 @@
 import GHC.Prelude
 import GHC.Types.Unique
 import GHC.Cmm.Expr
+import GHC.Word
 
-import Data.IntSet as IntSet
+import GHC.Data.Word64Set as Word64Set
 
 -- Compact sets for membership tests of local variables.
 
-type LRegSet = IntSet.IntSet
-type LRegKey = Int
+type LRegSet = Word64Set.Word64Set
+type LRegKey = Word64
 
 emptyLRegSet :: LRegSet
-emptyLRegSet = IntSet.empty
+emptyLRegSet = Word64Set.empty
 
 nullLRegSet :: LRegSet -> Bool
-nullLRegSet = IntSet.null
+nullLRegSet = Word64Set.null
 
 insertLRegSet :: LocalReg -> LRegSet -> LRegSet
-insertLRegSet l = IntSet.insert (getKey (getUnique l))
+insertLRegSet l = Word64Set.insert (getKey (getUnique l))
 
 elemLRegSet :: LocalReg -> LRegSet -> Bool
-elemLRegSet l = IntSet.member (getKey (getUnique l))
+elemLRegSet l = Word64Set.member (getKey (getUnique l))
 
 deleteFromLRegSet :: LRegSet -> LocalReg -> LRegSet
-deleteFromLRegSet set reg = IntSet.delete (getKey . getUnique $ reg) set
+deleteFromLRegSet set reg = Word64Set.delete (getKey . getUnique $ reg) set
 
-sizeLRegSet :: IntSet -> Int
-sizeLRegSet = IntSet.size
+sizeLRegSet :: Word64Set -> Int
+sizeLRegSet = Word64Set.size
 
-plusLRegSet :: IntSet -> IntSet -> IntSet
-plusLRegSet = IntSet.union
+plusLRegSet :: Word64Set -> Word64Set -> Word64Set
+plusLRegSet = Word64Set.union
 
-elemsLRegSet :: IntSet -> [Int]
-elemsLRegSet = IntSet.toList
+elemsLRegSet :: Word64Set -> [Word64]
+elemsLRegSet = Word64Set.toList
diff --git a/compiler/GHC/Cmm/Sink.hs b/compiler/GHC/Cmm/Sink.hs
--- a/compiler/GHC/Cmm/Sink.hs
+++ b/compiler/GHC/Cmm/Sink.hs
@@ -21,7 +21,7 @@
 import GHC.Platform
 import GHC.Types.Unique.FM
 
-import qualified Data.IntSet as IntSet
+import qualified GHC.Data.Word64Set as Word64Set
 import Data.List (partition)
 import Data.Maybe
 
@@ -175,7 +175,7 @@
       -- Annotate the middle nodes with the registers live *after*
       -- the node.  This will help us decide whether we can inline
       -- an assignment in the current node or not.
-      live = IntSet.unions (map getLive succs)
+      live = Word64Set.unions (map getLive succs)
       live_middle = gen_killL platform last live
       ann_middles = annotate platform live_middle (blockToList middle)
 
@@ -188,7 +188,7 @@
       -- one predecessor), so identify the join points and the set
       -- of registers live in them.
       (joins, nonjoins) = partition (`mapMember` join_pts) succs
-      live_in_joins = IntSet.unions (map getLive joins)
+      live_in_joins = Word64Set.unions (map getLive joins)
 
       -- We do not want to sink an assignment into multiple branches,
       -- so identify the set of registers live in multiple successors.
@@ -215,7 +215,7 @@
             live_sets' | should_drop = live_sets
                        | otherwise   = map upd live_sets
 
-            upd set | r `elemLRegSet` set = set `IntSet.union` live_rhs
+            upd set | r `elemLRegSet` set = set `Word64Set.union` live_rhs
                     | otherwise          = set
 
             live_rhs = foldRegsUsed platform (flip insertLRegSet) emptyLRegSet rhs
diff --git a/compiler/GHC/CmmToAsm/CFG.hs b/compiler/GHC/CmmToAsm/CFG.hs
--- a/compiler/GHC/CmmToAsm/CFG.hs
+++ b/compiler/GHC/CmmToAsm/CFG.hs
@@ -60,12 +60,16 @@
 import GHC.Types.Unique
 import qualified GHC.CmmToAsm.CFG.Dominators as Dom
 import GHC.CmmToAsm.CFG.Weight
+import GHC.Data.Word64Map.Strict (Word64Map)
+import GHC.Data.Word64Set (Word64Set)
 import Data.IntMap.Strict (IntMap)
 import Data.IntSet (IntSet)
 
 import qualified Data.IntMap.Strict as IM
+import qualified GHC.Data.Word64Map.Strict as WM
 import qualified Data.Map as M
 import qualified Data.IntSet as IS
+import qualified GHC.Data.Word64Set as WS
 import qualified Data.Set as S
 import Data.Tree
 import Data.Bifunctor
@@ -90,6 +94,7 @@
 
 import Control.Monad
 import GHC.Data.UnionFind
+import Data.Word
 
 type Prob = Double
 
@@ -851,7 +856,7 @@
 
     --TODO - This should be a no op: Export constructors? Use unsafeCoerce? ...
     rooted = ( fromBlockId root
-              , toIntMap $ fmap toIntSet graph) :: (Int, IntMap IntSet)
+              , toWord64Map $ fmap toWord64Set graph) :: (Word64, Word64Map Word64Set)
     tree = fmap toBlockId $ Dom.domTree rooted :: Tree BlockId
 
     -- Map from Nodes to their dominators
@@ -898,10 +903,10 @@
           loopCount n = length $ nub . map fst . filter (setMember n . snd) $ bodies
       in  map (\n -> (n, loopCount n)) $ nodes :: [(BlockId, Int)]
 
-    toIntSet :: LabelSet -> IntSet
-    toIntSet s = IS.fromList . map fromBlockId . setElems $ s
-    toIntMap :: LabelMap a -> IntMap a
-    toIntMap m = IM.fromList $ map (\(x,y) -> (fromBlockId x,y)) $ mapToList m
+    toWord64Set :: LabelSet -> Word64Set
+    toWord64Set s = WS.fromList . map fromBlockId . setElems $ s
+    toWord64Map :: LabelMap a -> Word64Map a
+    toWord64Map m = WM.fromList $ map (\(x,y) -> (fromBlockId x,y)) $ mapToList m
 
     mkDomMap :: Tree BlockId -> LabelMap LabelSet
     mkDomMap root = mapFromList $ go setEmpty root
@@ -916,10 +921,10 @@
                             (\n -> go (setInsert (rootLabel n) parents) n)
                             leaves
 
-    fromBlockId :: BlockId -> Int
+    fromBlockId :: BlockId -> Word64
     fromBlockId = getKey . getUnique
 
-    toBlockId :: Int -> BlockId
+    toBlockId :: Word64 -> BlockId
     toBlockId = mkBlockId . mkUniqueGrimily
 
 -- We make the CFG a Hoopl Graph, so we can reuse revPostOrder.
diff --git a/compiler/GHC/CmmToAsm/CFG/Dominators.hs b/compiler/GHC/CmmToAsm/CFG/Dominators.hs
--- a/compiler/GHC/CmmToAsm/CFG/Dominators.hs
+++ b/compiler/GHC/CmmToAsm/CFG/Dominators.hs
@@ -21,8 +21,8 @@
       /Advanced Compiler Design and Implementation/, 1997.
 
     \[3\] Brisk, Sarrafzadeh,
-      /Interference Graphs for Procedures in Static Single/
-      /Information Form are Interval Graphs/, 2007.
+      /Interference CGraphs for Procedures in Static Single/
+      /Information Form are Interval CGraphs/, 2007.
 
  * Strictness
 
@@ -40,7 +40,7 @@
   ,pddfs,rpddfs
   ,fromAdj,fromEdges
   ,toAdj,toEdges
-  ,asTree,asGraph
+  ,asTree,asCGraph
   ,parents,ancestors
 ) where
 
@@ -61,15 +61,24 @@
 import Data.Array.Base
   (unsafeNewArray_
   ,unsafeWrite,unsafeRead)
+import GHC.Data.Word64Set (Word64Set)
+import qualified GHC.Data.Word64Set as WS
+import GHC.Data.Word64Map (Word64Map)
+import qualified GHC.Data.Word64Map as WM
+import Data.Word
 
 -----------------------------------------------------------------------------
 
-type Node       = Int
-type Path       = [Node]
-type Edge       = (Node,Node)
-type Graph      = IntMap IntSet
-type Rooted     = (Node, Graph)
+-- Compacted nodes; these can be stored in contiguous arrays
+type CNode       = Int
+type CGraph      = IntMap IntSet
 
+type Node     = Word64
+type Path     = [Node]
+type Edge     = (Node, Node)
+type Graph    = Word64Map Word64Set
+type Rooted   = (Node, Graph)
+
 -----------------------------------------------------------------------------
 
 -- | /Dominators/.
@@ -111,7 +120,7 @@
 -- | /Immediate post-dominators/.
 -- Complexity as for @idom@.
 ipdom :: Rooted -> [(Node,Node)]
-ipdom rg = runST (evalS idomM =<< initEnv (pruneReach (second predG rg)))
+ipdom rg = runST (evalS idomM =<< initEnv (pruneReach (second predGW rg)))
 
 -----------------------------------------------------------------------------
 
@@ -126,24 +135,24 @@
 -----------------------------------------------------------------------------
 
 type Dom s a = S s (Env s) a
-type NodeSet    = IntSet
-type NodeMap a  = IntMap a
+type NodeSet    = Word64Set
+type NodeMap a  = Word64Map a
 data Env s = Env
-  {succE      :: !Graph
-  ,predE      :: !Graph
-  ,bucketE    :: !Graph
+  {succE      :: !CGraph
+  ,predE      :: !CGraph
+  ,bucketE    :: !CGraph
   ,dfsE       :: {-# UNPACK #-}!Int
-  ,zeroE      :: {-# UNPACK #-}!Node
-  ,rootE      :: {-# UNPACK #-}!Node
-  ,labelE     :: {-# UNPACK #-}!(Arr s Node)
-  ,parentE    :: {-# UNPACK #-}!(Arr s Node)
-  ,ancestorE  :: {-# UNPACK #-}!(Arr s Node)
-  ,childE     :: {-# UNPACK #-}!(Arr s Node)
-  ,ndfsE      :: {-# UNPACK #-}!(Arr s Node)
+  ,zeroE      :: {-# UNPACK #-}!CNode
+  ,rootE      :: {-# UNPACK #-}!CNode
+  ,labelE     :: {-# UNPACK #-}!(Arr s CNode)
+  ,parentE    :: {-# UNPACK #-}!(Arr s CNode)
+  ,ancestorE  :: {-# UNPACK #-}!(Arr s CNode)
+  ,childE     :: {-# UNPACK #-}!(Arr s CNode)
+  ,ndfsE      :: {-# UNPACK #-}!(Arr s CNode)
   ,dfnE       :: {-# UNPACK #-}!(Arr s Int)
   ,sdnoE      :: {-# UNPACK #-}!(Arr s Int)
   ,sizeE      :: {-# UNPACK #-}!(Arr s Int)
-  ,domE       :: {-# UNPACK #-}!(Arr s Node)
+  ,domE       :: {-# UNPACK #-}!(Arr s CNode)
   ,rnE        :: {-# UNPACK #-}!(Arr s Node)}
 
 -----------------------------------------------------------------------------
@@ -188,7 +197,7 @@
 
 -----------------------------------------------------------------------------
 
-eval :: Node -> Dom s Node
+eval :: CNode -> Dom s CNode
 eval v = do
   n0 <- zeroM
   a  <- ancestorM v
@@ -205,7 +214,7 @@
         True-> return l
         False-> return la
 
-compress :: Node -> Dom s ()
+compress :: CNode -> Dom s ()
 compress v = do
   n0  <- zeroM
   a   <- ancestorM v
@@ -224,7 +233,7 @@
 
 -----------------------------------------------------------------------------
 
-link :: Node -> Node -> Dom s ()
+link :: CNode -> CNode -> Dom s ()
 link v w = do
   n0  <- zeroM
   lw  <- labelM w
@@ -268,7 +277,7 @@
 
 -----------------------------------------------------------------------------
 
-dfsDom :: Node -> Dom s ()
+dfsDom :: CNode -> Dom s ()
 dfsDom i = do
   _   <- go i
   n0  <- zeroM
@@ -293,10 +302,10 @@
 
 initEnv :: Rooted -> ST s (Env s)
 initEnv (r0,g0) = do
-  -- Graph renumbered to indices from 1 to |V|
+  -- CGraph renumbered to indices from 1 to |V|
   let (g,rnmap) = renum 1 g0
       pred      = predG g -- reverse graph
-      root      = rnmap IM.! r0 -- renamed root
+      root      = rnmap WM.! r0 -- renamed root
       n         = IM.size g
       ns        = [0..n]
       m         = n+1
@@ -304,9 +313,9 @@
   let bucket = IM.fromList
         (zip ns (repeat mempty))
 
-  rna <- newI m
+  rna <- newW m
   writes rna (fmap swap
-        (IM.toList rnmap))
+        (WM.toList rnmap))
 
   doms      <- newI m
   sdno      <- newI m
@@ -361,33 +370,33 @@
 
 -----------------------------------------------------------------------------
 
-zeroM :: Dom s Node
+zeroM :: Dom s CNode
 zeroM = gets zeroE
-domM :: Node -> Dom s Node
+domM :: CNode -> Dom s CNode
 domM = fetch domE
-rootM :: Dom s Node
+rootM :: Dom s CNode
 rootM = gets rootE
-succsM :: Node -> Dom s [Node]
+succsM :: CNode -> Dom s [CNode]
 succsM i = gets (IS.toList . (! i) . succE)
-predsM :: Node -> Dom s [Node]
+predsM :: CNode -> Dom s [CNode]
 predsM i = gets (IS.toList . (! i) . predE)
-bucketM :: Node -> Dom s [Node]
+bucketM :: CNode -> Dom s [CNode]
 bucketM i = gets (IS.toList . (! i) . bucketE)
-sizeM :: Node -> Dom s Int
+sizeM :: CNode -> Dom s Int
 sizeM = fetch sizeE
-sdnoM :: Node -> Dom s Int
+sdnoM :: CNode -> Dom s Int
 sdnoM = fetch sdnoE
--- dfnM :: Node -> Dom s Int
+-- dfnM :: CNode -> Dom s Int
 -- dfnM = fetch dfnE
-ndfsM :: Int -> Dom s Node
+ndfsM :: Int -> Dom s CNode
 ndfsM = fetch ndfsE
-childM :: Node -> Dom s Node
+childM :: CNode -> Dom s CNode
 childM = fetch childE
-ancestorM :: Node -> Dom s Node
+ancestorM :: CNode -> Dom s CNode
 ancestorM = fetch ancestorE
-parentM :: Node -> Dom s Node
+parentM :: CNode -> Dom s CNode
 parentM = fetch parentE
-labelM :: Node -> Dom s Node
+labelM :: CNode -> Dom s CNode
 labelM = fetch labelE
 nextM :: Dom s Int
 nextM = do
@@ -422,6 +431,9 @@
 newI :: Int -> ST s (Arr s Int)
 newI = new
 
+newW :: Int -> ST s (Arr s Node)
+newW = new
+
 writes :: (MArray (A s) a (ST s))
      => Arr s a -> [(Int,a)] -> ST s ()
 writes a xs = forM_ xs (\(i,x) -> (a.=x) i)
@@ -431,18 +443,18 @@
 (!) g n = maybe mempty id (IM.lookup n g)
 
 fromAdj :: [(Node, [Node])] -> Graph
-fromAdj = IM.fromList . fmap (second IS.fromList)
+fromAdj = WM.fromList . fmap (second WS.fromList)
 
 fromEdges :: [Edge] -> Graph
-fromEdges = collectI IS.union fst (IS.singleton . snd)
+fromEdges = collectW WS.union fst (WS.singleton . snd)
 
 toAdj :: Graph -> [(Node, [Node])]
-toAdj = fmap (second IS.toList) . IM.toList
+toAdj = fmap (second WS.toList) . WM.toList
 
 toEdges :: Graph -> [Edge]
 toEdges = concatMap (uncurry (fmap . (,))) . toAdj
 
-predG :: Graph -> Graph
+predG :: CGraph -> CGraph
 predG g = IM.unionWith IS.union (go g) g0
   where g0 = fmap (const mempty) g
         go = flip IM.foldrWithKey mempty (\i a m ->
@@ -451,15 +463,24 @@
                         m
                        (IS.toList a))
 
+predGW :: Graph -> Graph
+predGW g = WM.unionWith WS.union (go g) g0
+  where g0 = fmap (const mempty) g
+        go = flip WM.foldrWithKey mempty (\i a m ->
+                foldl' (\m p -> WM.insertWith mappend p
+                                      (WS.singleton i) m)
+                        m
+                       (WS.toList a))
+
 pruneReach :: Rooted -> Rooted
 pruneReach (r,g) = (r,g2)
   where is = reachable
               (maybe mempty id
-                . flip IM.lookup g) $ r
-        g2 = IM.fromList
-            . fmap (second (IS.filter (`IS.member`is)))
-            . filter ((`IS.member`is) . fst)
-            . IM.toList $ g
+                . flip WM.lookup g) $ r
+        g2 = WM.fromList
+            . fmap (second (WS.filter (`WS.member`is)))
+            . filter ((`WS.member`is) . fst)
+            . WM.toList $ g
 
 tip :: Tree a -> (a, [Tree a])
 tip (Node a ts) = (a, ts)
@@ -476,26 +497,28 @@
             in p acc' xs ++ concatMap (go acc') xs
         p is = fmap (flip (,) is . rootLabel)
 
-asGraph :: Tree Node -> Rooted
-asGraph t@(Node a _) = let g = go t in (a, fromAdj g)
+asCGraph :: Tree Node -> Rooted
+asCGraph t@(Node a _) = let g = go t in (a, fromAdj g)
   where go (Node a ts) = let as = (fst . unzip . fmap tip) ts
                           in (a, as) : concatMap go ts
 
 asTree :: Rooted -> Tree Node
-asTree (r,g) = let go a = Node a (fmap go ((IS.toList . f) a))
+asTree (r,g) = let go a = Node a (fmap go ((WS.toList . f) a))
                    f = (g !)
             in go r
+  where (!) g n = maybe mempty id (WM.lookup n g)
 
+
 reachable :: (Node -> NodeSet) -> (Node -> NodeSet)
-reachable f a = go (IS.singleton a) a
+reachable f a = go (WS.singleton a) a
   where go seen a = let s = f a
-                        as = IS.toList (s `IS.difference` seen)
-                    in foldl' go (s `IS.union` seen) as
+                        as = WS.toList (s `WS.difference` seen)
+                    in foldl' go (s `WS.union` seen) as
 
-collectI :: (c -> c -> c)
-        -> (a -> Int) -> (a -> c) -> [a] -> IntMap c
-collectI (<>) f g
-  = foldl' (\m a -> IM.insertWith (<>)
+collectW :: (c -> c -> c)
+        -> (a -> Node) -> (a -> c) -> [a] -> Word64Map c
+collectW (<>) f g
+  = foldl' (\m a -> WM.insertWith (<>)
                                   (f a)
                                   (g a) m) mempty
 
@@ -504,12 +527,12 @@
 -- Gives nodes sequential names starting at n.
 -- Returns the new graph and a mapping.
 -- (renamed, old -> new)
-renum :: Int -> Graph -> (Graph, NodeMap Node)
+renum :: Int -> Graph -> (CGraph, NodeMap CNode)
 renum from = (\(_,m,g)->(g,m))
-  . IM.foldrWithKey
+  . WM.foldrWithKey
       (\i ss (!n,!env,!new)->
           let (j,n2,env2) = go n env i
-              (n3,env3,ss2) = IS.fold
+              (n3,env3,ss2) = WS.fold
                 (\k (!n,!env,!new)->
                     case go n env k of
                       (l,n2,env2)-> (n2,env2,l `IS.insert` new))
@@ -517,13 +540,13 @@
               new2 = IM.insertWith IS.union j ss2 new
           in (n3,env3,new2)) (from,mempty,mempty)
   where go :: Int
-           -> NodeMap Node
+           -> NodeMap CNode
            -> Node
-           -> (Node,Int,NodeMap Node)
+           -> (CNode,Int,NodeMap CNode)
         go !n !env i =
-          case IM.lookup i env of
+          case WM.lookup i env of
             Just j -> (j,n,env)
-            Nothing -> (n,n+1,IM.insert i n env)
+            Nothing -> (n,n+1,WM.insert i n env)
 
 -----------------------------------------------------------------------------
 
diff --git a/compiler/GHC/CmmToAsm/Wasm/Asm.hs b/compiler/GHC/CmmToAsm/Wasm/Asm.hs
--- a/compiler/GHC/CmmToAsm/Wasm/Asm.hs
+++ b/compiler/GHC/CmmToAsm/Wasm/Asm.hs
@@ -14,7 +14,7 @@
 import Data.ByteString.Builder
 import Data.Coerce
 import Data.Foldable
-import qualified Data.IntSet as IS
+import qualified GHC.Data.Word64Set as WS
 import Data.Maybe
 import Data.Semigroup
 import GHC.Cmm
@@ -181,9 +181,9 @@
 asmTellSectionHeader k = asmTellTabLine $ ".section " <> k <> ",\"\",@"
 
 asmTellDataSection ::
-  WasmTypeTag w -> IS.IntSet -> SymName -> DataSection -> WasmAsmM ()
+  WasmTypeTag w -> WS.Word64Set -> SymName -> DataSection -> WasmAsmM ()
 asmTellDataSection ty_word def_syms sym DataSection {..} = do
-  when (getKey (getUnique sym) `IS.member` def_syms) $ asmTellDefSym sym
+  when (getKey (getUnique sym) `WS.member` def_syms) $ asmTellDefSym sym
   asmTellSectionHeader sec_name
   asmTellAlign dataSectionAlignment
   asmTellTabLine asm_size
@@ -420,12 +420,12 @@
 
 asmTellFunc ::
   WasmTypeTag w ->
-  IS.IntSet ->
+  WS.Word64Set ->
   SymName ->
   (([SomeWasmType], [SomeWasmType]), FuncBody w) ->
   WasmAsmM ()
 asmTellFunc ty_word def_syms sym (func_ty, FuncBody {..}) = do
-  when (getKey (getUnique sym) `IS.member` def_syms) $ asmTellDefSym sym
+  when (getKey (getUnique sym) `WS.member` def_syms) $ asmTellDefSym sym
   asmTellSectionHeader $ ".text." <> asm_sym
   asmTellLine $ asm_sym <> ":"
   asmTellFuncType sym func_ty
diff --git a/compiler/GHC/CmmToAsm/Wasm/FromCmm.hs b/compiler/GHC/CmmToAsm/Wasm/FromCmm.hs
--- a/compiler/GHC/CmmToAsm/Wasm/FromCmm.hs
+++ b/compiler/GHC/CmmToAsm/Wasm/FromCmm.hs
@@ -26,7 +26,7 @@
 import qualified Data.ByteString as BS
 import Data.Foldable
 import Data.Functor
-import qualified Data.IntSet as IS
+import qualified GHC.Data.Word64Set as WS
 import Data.Semigroup
 import Data.String
 import Data.Traversable
@@ -1553,7 +1553,7 @@
   SymDefault -> wasmModifyM $ \s ->
     s
       { defaultSyms =
-          IS.insert
+          WS.insert
             (getKey $ getUnique sym)
             $ defaultSyms s
       }
diff --git a/compiler/GHC/CmmToAsm/Wasm/Types.hs b/compiler/GHC/CmmToAsm/Wasm/Types.hs
--- a/compiler/GHC/CmmToAsm/Wasm/Types.hs
+++ b/compiler/GHC/CmmToAsm/Wasm/Types.hs
@@ -52,7 +52,7 @@
 import Data.ByteString (ByteString)
 import Data.Coerce
 import Data.Functor
-import qualified Data.IntSet as IS
+import qualified GHC.Data.Word64Set as WS
 import Data.Kind
 import Data.String
 import Data.Type.Equality
@@ -197,7 +197,7 @@
 type SymMap = UniqMap SymName
 
 -- | No need to remember the symbols.
-type SymSet = IS.IntSet
+type SymSet = WS.Word64Set
 
 type GlobalInfo = (SymName, SomeWasmType)
 
@@ -427,7 +427,7 @@
   WasmCodeGenState
     { wasmPlatform =
         platform,
-      defaultSyms = IS.empty,
+      defaultSyms = WS.empty,
       funcTypes = emptyUniqMap,
       funcBodies =
         emptyUniqMap,
diff --git a/compiler/GHC/CmmToLlvm/Base.hs b/compiler/GHC/CmmToLlvm/Base.hs
--- a/compiler/GHC/CmmToLlvm/Base.hs
+++ b/compiler/GHC/CmmToLlvm/Base.hs
@@ -260,7 +260,7 @@
   , envConfig    :: !LlvmCgConfig    -- ^ Configuration for LLVM code gen
   , envLogger    :: !Logger          -- ^ Logger
   , envOutput    :: BufHandle        -- ^ Output buffer
-  , envMask      :: !Char            -- ^ Mask for creating unique values
+  , envTag       :: !Char            -- ^ Tag for creating unique values
   , envFreshMeta :: MetaId           -- ^ Supply of fresh metadata IDs
   , envUniqMeta  :: UniqFM Unique MetaId   -- ^ Global metadata nodes
   , envFunMap    :: LlvmEnvMap       -- ^ Global functions so far, with type
@@ -292,12 +292,12 @@
 
 instance MonadUnique LlvmM where
     getUniqueSupplyM = do
-        mask <- getEnv envMask
-        liftIO $! mkSplitUniqSupply mask
+        tag <- getEnv envTag
+        liftIO $! mkSplitUniqSupply tag
 
     getUniqueM = do
-        mask <- getEnv envMask
-        liftIO $! uniqFromMask mask
+        tag <- getEnv envTag
+        liftIO $! uniqFromTag tag
 
 -- | Lifting of IO actions. Not exported, as we want to encapsulate IO.
 liftIO :: IO a -> LlvmM a
@@ -318,7 +318,7 @@
                       , envConfig    = cfg
                       , envLogger    = logger
                       , envOutput    = out
-                      , envMask      = 'n'
+                      , envTag       = 'n'
                       , envFreshMeta = MetaId 0
                       , envUniqMeta  = emptyUFM
                       }
diff --git a/compiler/GHC/Core/Opt/Pipeline.hs b/compiler/GHC/Core/Opt/Pipeline.hs
--- a/compiler/GHC/Core/Opt/Pipeline.hs
+++ b/compiler/GHC/Core/Opt/Pipeline.hs
@@ -77,9 +77,9 @@
                                 , mg_loc     = loc
                                 , mg_rdr_env = rdr_env })
   = do { let builtin_passes = getCoreToDo dflags hpt_rule_base extra_vars
-             uniq_mask = 's'
+             uniq_tag = 's'
 
-       ; (guts2, stats) <- runCoreM hsc_env hpt_rule_base uniq_mask mod
+       ; (guts2, stats) <- runCoreM hsc_env hpt_rule_base uniq_tag mod
                                     name_ppr_ctx loc $
                            do { hsc_env' <- getHscEnv
                               ; all_passes <- withPlugins (hsc_plugins hsc_env')
diff --git a/compiler/GHC/Driver/Main.hs b/compiler/GHC/Driver/Main.hs
--- a/compiler/GHC/Driver/Main.hs
+++ b/compiler/GHC/Driver/Main.hs
@@ -248,7 +248,7 @@
 import GHC.Types.Name.Ppr
 import GHC.Types.TyThing
 import GHC.Types.HpcInfo
-import GHC.Types.Unique.Supply (uniqFromMask)
+import GHC.Types.Unique.Supply (uniqFromTag)
 import GHC.Types.Unique.Set
 
 import GHC.Utils.Fingerprint ( Fingerprint )
@@ -2595,7 +2595,7 @@
   --
   -- The id has to be exported for the JS backend. This isn't required for the
   -- byte-code interpreter but it does no harm to always do it.
-  u <- uniqFromMask 'I'
+  u <- uniqFromTag 'I'
   let binding_name = mkSystemVarName u (fsLit ("BCO_toplevel"))
   let binding_id   = mkExportedVanillaId binding_name (exprType simpl_expr)
 
diff --git a/compiler/GHC/Driver/Make.hs b/compiler/GHC/Driver/Make.hs
--- a/compiler/GHC/Driver/Make.hs
+++ b/compiler/GHC/Driver/Make.hs
@@ -155,7 +155,7 @@
 import GHC.Types.Unique
 import GHC.Iface.Errors.Types
 
-import qualified Data.IntSet as I
+import qualified GHC.Data.Word64Set as W
 
 -- -----------------------------------------------------------------------------
 -- Loading the program
@@ -340,10 +340,12 @@
     -- Note also that we can't always infer the associated module name
     -- directly from the filename argument.  See #13727.
     is_known_module mod =
-      (Map.lookup (moduleName (ms_mod mod)) mod_targets == Just (ms_unitid mod))
+      is_module_target mod
       ||
       maybe False is_file_target (ml_hs_file (ms_location mod))
 
+    is_module_target mod = (moduleName (ms_mod mod), ms_unitid mod) `Set.member` mod_targets
+
     is_file_target file = Set.member (withoutExt file) file_targets
 
     file_targets = Set.fromList (mapMaybe file_target targets)
@@ -354,7 +356,7 @@
         TargetFile file _ ->
           Just (withoutExt (augmentByWorkingDirectory dflags file))
 
-    mod_targets = Map.fromList (mod_target <$> targets)
+    mod_targets = Set.fromList (mod_target <$> targets)
 
     mod_target Target {targetUnitId, targetId} =
       case targetId of
@@ -2834,12 +2836,12 @@
 -}
 
 -- See Note [ModuleNameSet, efficiency and space leaks]
-type ModuleNameSet = M.Map UnitId I.IntSet
+type ModuleNameSet = M.Map UnitId W.Word64Set
 
 addToModuleNameSet :: UnitId -> ModuleName -> ModuleNameSet -> ModuleNameSet
 addToModuleNameSet uid mn s =
   let k = (getKey $ getUnique $ mn)
-  in M.insertWith (I.union) uid (I.singleton k) s
+  in M.insertWith (W.union) uid (W.singleton k) s
 
 -- | Wait for some dependencies to finish and then read from the given MVar.
 wait_deps_hug :: MVar HomeUnitGraph -> [BuildResult] -> ReaderT MakeEnv (MaybeT IO) (HomeUnitGraph, ModuleNameSet)
@@ -2850,7 +2852,7 @@
         let -- Restrict to things which are in the transitive closure to avoid retaining
             -- reference to loop modules which have already been compiled by other threads.
             -- See Note [ModuleNameSet, efficiency and space leaks]
-            !new = udfmRestrictKeysSet (homeUnitEnv_hpt hme) (fromMaybe I.empty $ M.lookup  uid module_deps)
+            !new = udfmRestrictKeysSet (homeUnitEnv_hpt hme) (fromMaybe W.empty $ M.lookup  uid module_deps)
         in hme { homeUnitEnv_hpt = new }
   return (unitEnv_mapWithKey pruneHomeUnitEnv hug, module_deps)
 
@@ -2865,7 +2867,7 @@
     Nothing -> return (hmis, new_deps)
     Just hmi -> return (hmi:hmis, new_deps)
   where
-    unionModuleNameSet = M.unionWith I.union
+    unionModuleNameSet = M.unionWith W.union
 
 
 -- Executing the pipelines
diff --git a/compiler/GHC/HsToCore/Breakpoints.hs b/compiler/GHC/HsToCore/Breakpoints.hs
--- a/compiler/GHC/HsToCore/Breakpoints.hs
+++ b/compiler/GHC/HsToCore/Breakpoints.hs
@@ -27,16 +27,18 @@
 
     breakArray <- GHCi.newBreakArray interp count
     ccs <- mkCCSArray interp mod count entries
+    mod_ptr <- GHCi.newModuleName interp (moduleName mod)
     let
            locsTicks  = listArray (0,count-1) [ tick_loc  t | t <- entries ]
            varsTicks  = listArray (0,count-1) [ tick_ids  t | t <- entries ]
            declsTicks = listArray (0,count-1) [ tick_path t | t <- entries ]
     return $ emptyModBreaks
-                       { modBreaks_flags = breakArray
-                       , modBreaks_locs  = locsTicks
-                       , modBreaks_vars  = varsTicks
-                       , modBreaks_decls = declsTicks
-                       , modBreaks_ccs   = ccs
+                       { modBreaks_flags  = breakArray
+                       , modBreaks_locs   = locsTicks
+                       , modBreaks_vars   = varsTicks
+                       , modBreaks_decls  = declsTicks
+                       , modBreaks_ccs    = ccs
+                       , modBreaks_module = mod_ptr
                        }
 
 mkCCSArray
diff --git a/compiler/GHC/HsToCore/Foreign/JavaScript.hs b/compiler/GHC/HsToCore/Foreign/JavaScript.hs
--- a/compiler/GHC/HsToCore/Foreign/JavaScript.hs
+++ b/compiler/GHC/HsToCore/Foreign/JavaScript.hs
@@ -156,7 +156,7 @@
 
   header_bits = maybe mempty idTag maybe_target
   idTag i = let (tag, u) = unpkUnique (getUnique i)
-            in  CHeader (char tag <> int u)
+            in  CHeader (char tag <> word64 u)
 
   fun_args
     | null arg_info = empty -- text "void"
diff --git a/compiler/GHC/HsToCore/Match/Literal.hs b/compiler/GHC/HsToCore/Match/Literal.hs
--- a/compiler/GHC/HsToCore/Match/Literal.hs
+++ b/compiler/GHC/HsToCore/Match/Literal.hs
@@ -64,6 +64,7 @@
 import GHC.Utils.Misc
 import GHC.Utils.Panic
 import GHC.Utils.Panic.Plain
+import GHC.Utils.Unique (sameUnique)
 
 import GHC.Data.FastString
 
@@ -319,29 +320,29 @@
  , Just (i, tc) <- lit
  = if
     -- These only show up via the 'HsOverLit' route
-    | tc == intTyConName        -> check i tc minInt         maxInt
-    | tc == wordTyConName       -> check i tc minWord        maxWord
-    | tc == int8TyConName       -> check i tc (min' @Int8)   (max' @Int8)
-    | tc == int16TyConName      -> check i tc (min' @Int16)  (max' @Int16)
-    | tc == int32TyConName      -> check i tc (min' @Int32)  (max' @Int32)
-    | tc == int64TyConName      -> check i tc (min' @Int64)  (max' @Int64)
-    | tc == word8TyConName      -> check i tc (min' @Word8)  (max' @Word8)
-    | tc == word16TyConName     -> check i tc (min' @Word16) (max' @Word16)
-    | tc == word32TyConName     -> check i tc (min' @Word32) (max' @Word32)
-    | tc == word64TyConName     -> check i tc (min' @Word64) (max' @Word64)
-    | tc == naturalTyConName    -> checkPositive i tc
+    | sameUnique tc intTyConName        -> check i tc minInt         maxInt
+    | sameUnique tc wordTyConName       -> check i tc minWord        maxWord
+    | sameUnique tc int8TyConName       -> check i tc (min' @Int8)   (max' @Int8)
+    | sameUnique tc int16TyConName      -> check i tc (min' @Int16)  (max' @Int16)
+    | sameUnique tc int32TyConName      -> check i tc (min' @Int32)  (max' @Int32)
+    | sameUnique tc int64TyConName      -> check i tc (min' @Int64)  (max' @Int64)
+    | sameUnique tc word8TyConName      -> check i tc (min' @Word8)  (max' @Word8)
+    | sameUnique tc word16TyConName     -> check i tc (min' @Word16) (max' @Word16)
+    | sameUnique tc word32TyConName     -> check i tc (min' @Word32) (max' @Word32)
+    | sameUnique tc word64TyConName     -> check i tc (min' @Word64) (max' @Word64)
+    | sameUnique tc naturalTyConName    -> checkPositive i tc
 
     -- These only show up via the 'HsLit' route
-    | tc == intPrimTyConName    -> check i tc minInt         maxInt
-    | tc == wordPrimTyConName   -> check i tc minWord        maxWord
-    | tc == int8PrimTyConName   -> check i tc (min' @Int8)   (max' @Int8)
-    | tc == int16PrimTyConName  -> check i tc (min' @Int16)  (max' @Int16)
-    | tc == int32PrimTyConName  -> check i tc (min' @Int32)  (max' @Int32)
-    | tc == int64PrimTyConName  -> check i tc (min' @Int64)  (max' @Int64)
-    | tc == word8PrimTyConName  -> check i tc (min' @Word8)  (max' @Word8)
-    | tc == word16PrimTyConName -> check i tc (min' @Word16) (max' @Word16)
-    | tc == word32PrimTyConName -> check i tc (min' @Word32) (max' @Word32)
-    | tc == word64PrimTyConName -> check i tc (min' @Word64) (max' @Word64)
+    | sameUnique tc intPrimTyConName    -> check i tc minInt         maxInt
+    | sameUnique tc wordPrimTyConName   -> check i tc minWord        maxWord
+    | sameUnique tc int8PrimTyConName   -> check i tc (min' @Int8)   (max' @Int8)
+    | sameUnique tc int16PrimTyConName  -> check i tc (min' @Int16)  (max' @Int16)
+    | sameUnique tc int32PrimTyConName  -> check i tc (min' @Int32)  (max' @Int32)
+    | sameUnique tc int64PrimTyConName  -> check i tc (min' @Int64)  (max' @Int64)
+    | sameUnique tc word8PrimTyConName  -> check i tc (min' @Word8)  (max' @Word8)
+    | sameUnique tc word16PrimTyConName -> check i tc (min' @Word16) (max' @Word16)
+    | sameUnique tc word32PrimTyConName -> check i tc (min' @Word32) (max' @Word32)
+    | sameUnique tc word64PrimTyConName -> check i tc (min' @Word64) (max' @Word64)
 
     | otherwise -> return ()
 
@@ -398,22 +399,22 @@
 
       platform <- targetPlatform <$> getDynFlags
          -- Be careful to use target Int/Word sizes! cf #17336
-      if | tc == intTyConName     -> case platformWordSize platform of
-                                      PW4 -> check @Int32
-                                      PW8 -> check @Int64
-         | tc == wordTyConName    -> case platformWordSize platform of
-                                      PW4 -> check @Word32
-                                      PW8 -> check @Word64
-         | tc == int8TyConName    -> check @Int8
-         | tc == int16TyConName   -> check @Int16
-         | tc == int32TyConName   -> check @Int32
-         | tc == int64TyConName   -> check @Int64
-         | tc == word8TyConName   -> check @Word8
-         | tc == word16TyConName  -> check @Word16
-         | tc == word32TyConName  -> check @Word32
-         | tc == word64TyConName  -> check @Word64
-         | tc == integerTyConName -> check @Integer
-         | tc == naturalTyConName -> check @Integer
+      if | sameUnique tc intTyConName     -> case platformWordSize platform of
+                                               PW4 -> check @Int32
+                                               PW8 -> check @Int64
+         | sameUnique tc wordTyConName    -> case platformWordSize platform of
+                                               PW4 -> check @Word32
+                                               PW8 -> check @Word64
+         | sameUnique tc int8TyConName    -> check @Int8
+         | sameUnique tc int16TyConName   -> check @Int16
+         | sameUnique tc int32TyConName   -> check @Int32
+         | sameUnique tc int64TyConName   -> check @Int64
+         | sameUnique tc word8TyConName   -> check @Word8
+         | sameUnique tc word16TyConName  -> check @Word16
+         | sameUnique tc word32TyConName  -> check @Word32
+         | sameUnique tc word64TyConName  -> check @Word64
+         | sameUnique tc integerTyConName -> check @Integer
+         | sameUnique tc naturalTyConName -> check @Integer
             -- We use 'Integer' because otherwise a negative 'Natural' literal
             -- could cause a compile time crash (instead of a runtime one).
             -- See the T10930b test case for an example of where this matters.
diff --git a/compiler/GHC/Linker/Deps.hs b/compiler/GHC/Linker/Deps.hs
--- a/compiler/GHC/Linker/Deps.hs
+++ b/compiler/GHC/Linker/Deps.hs
@@ -1,3 +1,8 @@
+-- The transition from Int to Word64 for uniques makes functions slightly larger
+-- without this GHC option some optimizations fail to fire.
+-- See https://gitlab.haskell.org/ghc/ghc/-/merge_requests/10568#note_505751
+{-# OPTIONS_GHC -fspec-constr-threshold=10000 #-}
+
 {-# LANGUAGE CPP #-}
 {-# LANGUAGE TupleSections, RecordWildCards #-}
 {-# LANGUAGE BangPatterns #-}
diff --git a/compiler/GHC/Runtime/Eval.hs b/compiler/GHC/Runtime/Eval.hs
--- a/compiler/GHC/Runtime/Eval.hs
+++ b/compiler/GHC/Runtime/Eval.hs
@@ -325,15 +325,14 @@
   | otherwise              = not_tracing
  where
   tracing
-    | EvalBreak is_exception apStack_ref ix mod_uniq resume_ctxt _ccs <- status
+    | EvalBreak is_exception apStack_ref ix mod_name resume_ctxt _ccs <- status
     , not is_exception
     = do
        hsc_env <- getSession
        let interp = hscInterp hsc_env
        let dflags = hsc_dflags hsc_env
        let hmi = expectJust "handleRunStatus" $
-                   lookupHptDirectly (hsc_HPT hsc_env)
-                                     (mkUniqueGrimily mod_uniq)
+                   lookupHpt (hsc_HPT hsc_env) (mkModuleName mod_name)
            modl = mi_module (hm_iface hmi)
            breaks = getModBreaks hmi
 
@@ -358,15 +357,14 @@
 
   not_tracing
     -- Hit a breakpoint
-    | EvalBreak is_exception apStack_ref ix mod_uniq resume_ctxt ccs <- status
+    | EvalBreak is_exception apStack_ref ix mod_name resume_ctxt ccs <- status
     = do
          hsc_env <- getSession
          let interp = hscInterp hsc_env
          resume_ctxt_fhv <- liftIO $ mkFinalizedHValue interp resume_ctxt
          apStack_fhv <- liftIO $ mkFinalizedHValue interp apStack_ref
          let hmi = expectJust "handleRunStatus" $
-                     lookupHptDirectly (hsc_HPT hsc_env)
-                                       (mkUniqueGrimily mod_uniq)
+                     lookupHpt (hsc_HPT hsc_env) (mkModuleName mod_name)
              modl = mi_module (hm_iface hmi)
              bp | is_exception = Nothing
                 | otherwise = Just (BreakInfo modl ix)
diff --git a/compiler/GHC/Runtime/Interpreter.hs b/compiler/GHC/Runtime/Interpreter.hs
--- a/compiler/GHC/Runtime/Interpreter.hs
+++ b/compiler/GHC/Runtime/Interpreter.hs
@@ -25,6 +25,7 @@
   , mkCostCentres
   , costCentreStackInfo
   , newBreakArray
+  , newModuleName
   , storeBreakpoint
   , breakpointStatus
   , getBreakpointVar
@@ -84,7 +85,6 @@
 import GHC.Data.Maybe
 import GHC.Data.FastString
 
-import GHC.Types.Unique
 import GHC.Types.SrcLoc
 import GHC.Types.Unique.FM
 import GHC.Types.Basic
@@ -381,6 +381,10 @@
   breakArray <- interpCmd interp (NewBreakArray size)
   mkFinalizedHValue interp breakArray
 
+newModuleName :: Interp -> ModuleName -> IO (RemotePtr ModuleName)
+newModuleName interp mod_name =
+  castRemotePtr <$> interpCmd interp (NewBreakModule (moduleNameString mod_name))
+
 storeBreakpoint :: Interp -> ForeignRef BreakArray -> Int -> Int -> IO ()
 storeBreakpoint interp ref ix cnt = do                               -- #19157
   withForeignRef ref $ \breakarray ->
@@ -414,13 +418,12 @@
 handleSeqHValueStatus :: Interp -> UnitEnv -> EvalStatus () -> IO (EvalResult ())
 handleSeqHValueStatus interp unit_env eval_status =
   case eval_status of
-    (EvalBreak is_exception _ ix mod_uniq resume_ctxt _) -> do
+    (EvalBreak is_exception _ ix mod_name resume_ctxt _) -> do
       -- A breakpoint was hit; inform the user and tell them
       -- which breakpoint was hit.
       resume_ctxt_fhv <- liftIO $ mkFinalizedHValue interp resume_ctxt
       let hmi = expectJust "handleRunStatus" $
-                  lookupHptDirectly (ue_hpt unit_env)
-                    (mkUniqueGrimily mod_uniq)
+                  lookupHpt (ue_hpt unit_env) (mkModuleName mod_name)
           modl = mi_module (hm_iface hmi)
           bp | is_exception = Nothing
              | otherwise = Just (BreakInfo modl ix)
diff --git a/compiler/GHC/Stg/Pipeline.hs b/compiler/GHC/Stg/Pipeline.hs
--- a/compiler/GHC/Stg/Pipeline.hs
+++ b/compiler/GHC/Stg/Pipeline.hs
@@ -58,10 +58,10 @@
   deriving (Functor, Applicative, Monad, MonadIO)
 
 instance MonadUnique StgM where
-  getUniqueSupplyM = StgM $ do { mask <- ask
-                               ; liftIO $! mkSplitUniqSupply mask}
-  getUniqueM = StgM $ do { mask <- ask
-                         ; liftIO $! uniqFromMask mask}
+  getUniqueSupplyM = StgM $ do { tag <- ask
+                               ; liftIO $! mkSplitUniqSupply tag}
+  getUniqueM = StgM $ do { tag <- ask
+                         ; liftIO $! uniqFromTag tag}
 
 runStgM :: Char -> StgM a -> IO a
 runStgM mask (StgM m) = runReaderT m mask
diff --git a/compiler/GHC/StgToByteCode.hs b/compiler/GHC/StgToByteCode.hs
--- a/compiler/GHC/StgToByteCode.hs
+++ b/compiler/GHC/StgToByteCode.hs
@@ -53,7 +53,6 @@
 import GHC.Builtin.Types.Prim
 import GHC.Core.TyCo.Ppr ( pprType )
 import GHC.Utils.Error
-import GHC.Types.Unique
 import GHC.Builtin.Uniques
 import GHC.Data.FastString
 import GHC.Utils.Panic
@@ -392,7 +391,6 @@
 schemeER_wrk d p (StgTick (Breakpoint tick_ty tick_no fvs) rhs)
   = do  code <- schemeE d 0 p rhs
         cc_arr <- getCCArray
-        this_mod <- moduleName <$> getCurrentModule
         platform <- profilePlatform <$> getProfile
         let idOffSets = getVarOffSets platform d p fvs
             ty_vars   = tyCoVarsOfTypesWellScoped (tick_ty:map idType fvs)
@@ -405,8 +403,12 @@
                , interpreterProfiled interp
                = cc_arr ! tick_no
                | otherwise = toRemotePtr nullPtr
-        let breakInstr = BRK_FUN (fromIntegral tick_no) (getUnique this_mod) cc
-        return $ breakInstr `consOL` code
+        mb_mod_name <- getCurrentModuleName
+        case mb_mod_name of
+          Just mod_ptr -> do
+            let breakInstr = BRK_FUN (fromIntegral tick_no) mod_ptr cc
+            return $ breakInstr `consOL` code
+          Nothing -> return code
 schemeER_wrk d p rhs = schemeE d 0 p rhs
 
 getVarOffSets :: Platform -> StackDepth -> BCEnv -> [Id] -> [Maybe (Id, WordOff)]
@@ -2263,8 +2265,8 @@
 newBreakInfo ix info = BcM $ \st ->
   return (st{breakInfo = IntMap.insert ix info (breakInfo st)}, ())
 
-getCurrentModule :: BcM Module
-getCurrentModule = BcM $ \st -> return (st, thisModule st)
+getCurrentModuleName :: BcM (Maybe (RemotePtr ModuleName))
+getCurrentModuleName = BcM $ \st -> return (st, modBreaks_module <$> modBreaks st)
 
 tickFS :: FastString
 tickFS = fsLit "ticked"
diff --git a/compiler/GHC/StgToCmm/Ticky.hs b/compiler/GHC/StgToCmm/Ticky.hs
--- a/compiler/GHC/StgToCmm/Ticky.hs
+++ b/compiler/GHC/StgToCmm/Ticky.hs
@@ -157,6 +157,7 @@
 import GHC.StgToCmm.Env (getCgInfo_maybe)
 import Data.Coerce (coerce)
 import GHC.Utils.Json
+import GHC.Utils.Unique (anyOfUnique)
 
 -----------------------------------------------------------------------------
 --
@@ -884,20 +885,19 @@
   | otherwise = case tcSplitTyConApp_maybe ty of
   Nothing -> '.'
   Just (tycon, _) ->
-    let anyOf us = getUnique tycon `elem` us in
     case () of
-      _ | anyOf [fUNTyConKey] -> '>'
-        | anyOf [charTyConKey] -> 'C'
-        | anyOf [charPrimTyConKey] -> 'c'
-        | anyOf [doubleTyConKey] -> 'D'
-        | anyOf [doublePrimTyConKey] -> 'd'
-        | anyOf [floatTyConKey] -> 'F'
-        | anyOf [floatPrimTyConKey] -> 'f'
-        | anyOf [intTyConKey, int8TyConKey, int16TyConKey, int32TyConKey, int64TyConKey] -> 'I'
-        | anyOf [intPrimTyConKey, int8PrimTyConKey, int16PrimTyConKey, int32PrimTyConKey, int64PrimTyConKey] -> 'i'
-        | anyOf [wordTyConKey, word8TyConKey, word16TyConKey, word32TyConKey, word64TyConKey] -> 'W'
-        | anyOf [wordPrimTyConKey, word8PrimTyConKey, word16PrimTyConKey, word32PrimTyConKey, word64PrimTyConKey] -> 'w'
-        | anyOf [listTyConKey] -> 'L'
+      _ | anyOfUnique tycon [fUNTyConKey] -> '>'
+        | anyOfUnique tycon [charTyConKey] -> 'C'
+        | anyOfUnique tycon [charPrimTyConKey] -> 'c'
+        | anyOfUnique tycon [doubleTyConKey] -> 'D'
+        | anyOfUnique tycon [doublePrimTyConKey] -> 'd'
+        | anyOfUnique tycon [floatTyConKey] -> 'F'
+        | anyOfUnique tycon [floatPrimTyConKey] -> 'f'
+        | anyOfUnique tycon [intTyConKey, int8TyConKey, int16TyConKey, int32TyConKey, int64TyConKey] -> 'I'
+        | anyOfUnique tycon [intPrimTyConKey, int8PrimTyConKey, int16PrimTyConKey, int32PrimTyConKey, int64PrimTyConKey] -> 'i'
+        | anyOfUnique tycon [wordTyConKey, word8TyConKey, word16TyConKey, word32TyConKey, word64TyConKey] -> 'W'
+        | anyOfUnique tycon [wordPrimTyConKey, word8PrimTyConKey, word16PrimTyConKey, word32PrimTyConKey, word64PrimTyConKey] -> 'w'
+        | anyOfUnique tycon [listTyConKey] -> 'L'
         | isUnboxedTupleTyCon tycon -> 't'
         | isTupleTyCon tycon       -> 'T'
         | isPrimTyCon tycon        -> 'P'
diff --git a/compiler/GHC/StgToJS/Deps.hs b/compiler/GHC/StgToJS/Deps.hs
--- a/compiler/GHC/StgToJS/Deps.hs
+++ b/compiler/GHC/StgToJS/Deps.hs
@@ -45,18 +45,19 @@
 import qualified Data.Map as M
 import qualified Data.Set as S
 import qualified Data.IntSet as IS
-import qualified Data.IntMap as IM
-import Data.IntMap (IntMap)
+import qualified GHC.Data.Word64Map as WM
+import GHC.Data.Word64Map (Word64Map)
 import Data.Array
 import Data.Either
+import Data.Word
 import Control.Monad
 
 import Control.Monad.Trans.Class
 import Control.Monad.Trans.State
 
 data DependencyDataCache = DDC
-  { ddcModule :: !(IntMap Unit)        -- ^ Unique Module -> Unit
-  , ddcId     :: !(IntMap ExportedFun) -- ^ Unique Id     -> ExportedFun (only to other modules)
+  { ddcModule :: !(Word64Map Unit)               -- ^ Unique Module -> Unit
+  , ddcId     :: !(Word64Map ExportedFun)        -- ^ Unique Id     -> ExportedFun (only to other modules)
   , ddcOther  :: !(Map OtherSymb ExportedFun)
   }
 
@@ -71,7 +72,7 @@
   -> G BlockInfo
 genDependencyData mod units = do
     ds <- evalStateT (mapM (uncurry oneDep) blocks)
-                     (DDC IM.empty IM.empty M.empty)
+                     (DDC WM.empty WM.empty M.empty)
     return $ BlockInfo
       { bi_module     = mod
       , bi_must_link  = IS.fromList [ n | (n, _, True, _) <- ds ]
@@ -144,7 +145,7 @@
             in  if m == mod
                    then pprPanic "local id not found" (ppr m)
                     else Left <$> do
-                            mr <- gets (IM.lookup k . ddcId)
+                            mr <- gets (WM.lookup k . ddcId)
                             maybe addEntry return mr
 
       -- get the function for an OtherSymb from the cache, add it if necessary
@@ -167,7 +168,7 @@
 
       -- lookup a dependency to another module, add to the id cache if there's
       -- an id key, otherwise add to other cache
-      lookupExternalFun :: Maybe Int
+      lookupExternalFun :: Maybe Word64
                         -> OtherSymb -> StateT DependencyDataCache G ExportedFun
       lookupExternalFun mbIdKey od@(OtherSymb m idTxt) = do
         let mk        = getKey . getUnique $ m
@@ -175,17 +176,17 @@
             exp_fun   = ExportedFun m (LexicalFastString idTxt)
             addCache  = do
               ms <- gets ddcModule
-              let !cache' = IM.insert mk mpk ms
+              let !cache' = WM.insert mk mpk ms
               modify (\s -> s { ddcModule = cache'})
               pure exp_fun
         f <- do
-          mbm <- gets (IM.member mk . ddcModule)
+          mbm <- gets (WM.member mk . ddcModule)
           case mbm of
             False -> addCache
             True  -> pure exp_fun
 
         case mbIdKey of
           Nothing -> modify (\s -> s { ddcOther = M.insert od f (ddcOther s) })
-          Just k  -> modify (\s -> s { ddcId    = IM.insert k f (ddcId s) })
+          Just k  -> modify (\s -> s { ddcId    = WM.insert k f (ddcId s) })
 
         return f
diff --git a/compiler/GHC/StgToJS/Ids.hs b/compiler/GHC/StgToJS/Ids.hs
--- a/compiler/GHC/StgToJS/Ids.hs
+++ b/compiler/GHC/StgToJS/Ids.hs
@@ -131,7 +131,7 @@
       , if exported
           then mempty
           else let (c,u) = unpkUnique (getUnique i)
-               in mconcat [BSC.pack ['_',c,'_'], intBS u]
+               in mconcat [BSC.pack ['_',c,'_'], word64BS u]
       ]
 
 -- | Retrieve the cached Ident for the given Id if there is one. Otherwise make
diff --git a/compiler/GHC/StgToJS/Symbols.hs b/compiler/GHC/StgToJS/Symbols.hs
--- a/compiler/GHC/StgToJS/Symbols.hs
+++ b/compiler/GHC/StgToJS/Symbols.hs
@@ -8,23 +8,32 @@
   , mkFreshJsSymbol
   , mkRawSymbol
   , intBS
+  , word64BS
   ) where
 
 import GHC.Prelude
 
 import GHC.Data.FastString
 import GHC.Unit.Module
+import GHC.Utils.Word64 (intToWord64)
 import Data.ByteString (ByteString)
+import Data.Word (Word64)
 import qualified Data.ByteString.Char8   as BSC
 import qualified Data.ByteString.Builder as BSB
 import qualified Data.ByteString.Lazy    as BSL
 
 -- | Hexadecimal representation of an int
 --
+-- Used for the sub indices.
+intBS :: Int -> ByteString
+intBS = word64BS . intToWord64
+
+-- | Hexadecimal representation of a 64-bit word
+--
 -- Used for uniques. We could use base-62 as GHC usually does but this is likely
 -- faster.
-intBS :: Int -> ByteString
-intBS = BSL.toStrict . BSB.toLazyByteString . BSB.wordHex . fromIntegral
+word64BS :: Word64 -> ByteString
+word64BS = BSL.toStrict . BSB.toLazyByteString . BSB.word64Hex
 
 -- | Return z-encoded unit:module
 unitModuleStringZ :: Module -> ByteString
diff --git a/compiler/GHC/Tc/Deriv/Utils.hs b/compiler/GHC/Tc/Deriv/Utils.hs
--- a/compiler/GHC/Tc/Deriv/Utils.hs
+++ b/compiler/GHC/Tc/Deriv/Utils.hs
@@ -66,6 +66,7 @@
 import GHC.Utils.Outputable
 import GHC.Utils.Panic
 import GHC.Utils.Error
+import GHC.Utils.Unique (sameUnique)
 
 import Control.Monad.Trans.Reader
 import Data.Foldable (traverse_)
@@ -893,37 +894,37 @@
 -- class for which stock deriving isn't possible.
 stockSideConditions :: DerivContext -> Class -> Maybe Condition
 stockSideConditions deriv_ctxt cls
-  | cls_key == eqClassKey          = Just (cond_std `andCond` cond_args cls)
-  | cls_key == ordClassKey         = Just (cond_std `andCond` cond_args cls)
-  | cls_key == showClassKey        = Just (cond_std `andCond` cond_args cls)
-  | cls_key == readClassKey        = Just (cond_std `andCond` cond_args cls)
-  | cls_key == enumClassKey        = Just (cond_std `andCond` cond_isEnumeration)
-  | cls_key == ixClassKey          = Just (cond_std `andCond` cond_enumOrProduct cls)
-  | cls_key == boundedClassKey     = Just (cond_std `andCond` cond_enumOrProduct cls)
-  | cls_key == dataClassKey        = Just (checkFlag LangExt.DeriveDataTypeable `andCond`
-                                           cond_vanilla `andCond`
-                                           cond_args cls)
-  | cls_key == functorClassKey     = Just (checkFlag LangExt.DeriveFunctor `andCond`
-                                           cond_vanilla `andCond`
-                                           cond_functorOK True False)
-  | cls_key == foldableClassKey    = Just (checkFlag LangExt.DeriveFoldable `andCond`
-                                           cond_vanilla `andCond`
-                                           cond_functorOK False True)
-                                           -- Functor/Fold/Trav works ok
-                                           -- for rank-n types
-  | cls_key == traversableClassKey = Just (checkFlag LangExt.DeriveTraversable `andCond`
-                                           cond_vanilla `andCond`
-                                           cond_functorOK False False)
-  | cls_key == genClassKey         = Just (checkFlag LangExt.DeriveGeneric `andCond`
-                                           cond_vanilla `andCond`
-                                           cond_RepresentableOk)
-  | cls_key == gen1ClassKey        = Just (checkFlag LangExt.DeriveGeneric `andCond`
-                                           cond_vanilla `andCond`
-                                           cond_Representable1Ok)
-  | cls_key == liftClassKey        = Just (checkFlag LangExt.DeriveLift `andCond`
-                                           cond_vanilla `andCond`
-                                           cond_args cls)
-  | otherwise                      = Nothing
+  | sameUnique cls_key eqClassKey          = Just (cond_std `andCond` cond_args cls)
+  | sameUnique cls_key ordClassKey         = Just (cond_std `andCond` cond_args cls)
+  | sameUnique cls_key showClassKey        = Just (cond_std `andCond` cond_args cls)
+  | sameUnique cls_key readClassKey        = Just (cond_std `andCond` cond_args cls)
+  | sameUnique cls_key enumClassKey        = Just (cond_std `andCond` cond_isEnumeration)
+  | sameUnique cls_key ixClassKey          = Just (cond_std `andCond` cond_enumOrProduct cls)
+  | sameUnique cls_key boundedClassKey     = Just (cond_std `andCond` cond_enumOrProduct cls)
+  | sameUnique cls_key dataClassKey        = Just (checkFlag LangExt.DeriveDataTypeable `andCond`
+                                                   cond_vanilla `andCond`
+                                                   cond_args cls)
+  | sameUnique cls_key functorClassKey     = Just (checkFlag LangExt.DeriveFunctor `andCond`
+                                                   cond_vanilla `andCond`
+                                                   cond_functorOK True False)
+  | sameUnique cls_key foldableClassKey    = Just (checkFlag LangExt.DeriveFoldable `andCond`
+                                                   cond_vanilla `andCond`
+                                                   cond_functorOK False True)
+                                                   -- Functor/Fold/Trav works ok
+                                                   -- for rank-n types
+  | sameUnique cls_key traversableClassKey = Just (checkFlag LangExt.DeriveTraversable `andCond`
+                                                   cond_vanilla `andCond`
+                                                   cond_functorOK False False)
+  | sameUnique cls_key genClassKey         = Just (checkFlag LangExt.DeriveGeneric `andCond`
+                                                   cond_vanilla `andCond`
+                                                   cond_RepresentableOk)
+  | sameUnique cls_key gen1ClassKey        = Just (checkFlag LangExt.DeriveGeneric `andCond`
+                                                   cond_vanilla `andCond`
+                                                   cond_Representable1Ok)
+  | sameUnique cls_key liftClassKey        = Just (checkFlag LangExt.DeriveLift `andCond`
+                                                   cond_vanilla `andCond`
+                                                   cond_args cls)
+  | otherwise                        = Nothing
   where
     cls_key = getUnique cls
     cond_std     = cond_stdOK deriv_ctxt False
diff --git a/compiler/GHC/Tc/Gen/Foreign.hs b/compiler/GHC/Tc/Gen/Foreign.hs
--- a/compiler/GHC/Tc/Gen/Foreign.hs
+++ b/compiler/GHC/Tc/Gen/Foreign.hs
@@ -71,6 +71,7 @@
 import GHC.Utils.Error
 import GHC.Utils.Outputable as Outputable
 import GHC.Utils.Panic
+import GHC.Utils.Unique
 import GHC.Platform
 
 import GHC.Data.Bag
@@ -741,16 +742,16 @@
 
 boxedMarshalableTyCon :: TyCon -> Validity' TypeCannotBeMarshaledReason
 boxedMarshalableTyCon tc
-   | getUnique tc `elem` [ intTyConKey, int8TyConKey, int16TyConKey
-                         , int32TyConKey, int64TyConKey
-                         , wordTyConKey, word8TyConKey, word16TyConKey
-                         , word32TyConKey, word64TyConKey
-                         , floatTyConKey, doubleTyConKey
-                         , ptrTyConKey, funPtrTyConKey
-                         , charTyConKey
-                         , stablePtrTyConKey
-                         , boolTyConKey
-                         ]
+   | anyOfUnique tc [ intTyConKey, int8TyConKey, int16TyConKey
+                    , int32TyConKey, int64TyConKey
+                    , wordTyConKey, word8TyConKey, word16TyConKey
+                    , word32TyConKey, word64TyConKey
+                    , floatTyConKey, doubleTyConKey
+                    , ptrTyConKey, funPtrTyConKey
+                    , charTyConKey
+                    , stablePtrTyConKey
+                    , boolTyConKey
+                    ]
   = IsValid
 
   | otherwise = NotValid NotABoxedMarshalableTyCon
diff --git a/compiler/GHC/Tc/Utils/Instantiate.hs b/compiler/GHC/Tc/Utils/Instantiate.hs
--- a/compiler/GHC/Tc/Utils/Instantiate.hs
+++ b/compiler/GHC/Tc/Utils/Instantiate.hs
@@ -90,6 +90,7 @@
 import GHC.Utils.Panic
 import GHC.Utils.Panic.Plain
 import GHC.Utils.Outputable
+import GHC.Utils.Unique (sameUnique)
 
 import GHC.Unit.State
 import GHC.Unit.External
@@ -792,17 +793,17 @@
      in hasFixedRuntimeRep_syntactic (FRRArrow $ ArrowFun user_expr) res_ty
    mb_arity :: Maybe Arity
    mb_arity -- arity of the arrow operation, counting type-level arguments
-     | std_nm == arrAName     -- result used as an argument in, e.g., do_premap
+     | sameUnique std_nm arrAName     -- result used as an argument in, e.g., do_premap
      = Just 3
-     | std_nm == composeAName -- result used as an argument in, e.g., dsCmdStmt/BodyStmt
+     | sameUnique std_nm composeAName -- result used as an argument in, e.g., dsCmdStmt/BodyStmt
      = Just 5
-     | std_nm == firstAName   -- result used as an argument in, e.g., dsCmdStmt/BodyStmt
+     | sameUnique std_nm firstAName   -- result used as an argument in, e.g., dsCmdStmt/BodyStmt
      = Just 4
-     | std_nm == appAName     -- result used as an argument in, e.g., dsCmd/HsCmdArrApp/HsHigherOrderApp
+     | sameUnique std_nm appAName     -- result used as an argument in, e.g., dsCmd/HsCmdArrApp/HsHigherOrderApp
      = Just 2
-     | std_nm == choiceAName  -- result used as an argument in, e.g., HsCmdIf
+     | sameUnique std_nm choiceAName  -- result used as an argument in, e.g., HsCmdIf
      = Just 5
-     | std_nm == loopAName    -- result used as an argument in, e.g., HsCmdIf
+     | sameUnique std_nm loopAName    -- result used as an argument in, e.g., HsCmdIf
      = Just 4
      | otherwise
      = Nothing
diff --git a/compiler/GHC/Tc/Utils/Monad.hs b/compiler/GHC/Tc/Utils/Monad.hs
--- a/compiler/GHC/Tc/Utils/Monad.hs
+++ b/compiler/GHC/Tc/Utils/Monad.hs
@@ -454,14 +454,14 @@
 ************************************************************************
 -}
 
-initTcRnIf :: Char              -- ^ Mask for unique supply
+initTcRnIf :: Char              -- ^ Tag for unique supply
            -> HscEnv
            -> gbl -> lcl
            -> TcRnIf gbl lcl a
            -> IO a
-initTcRnIf uniq_mask hsc_env gbl_env lcl_env thing_inside
+initTcRnIf uniq_tag hsc_env gbl_env lcl_env thing_inside
    = do { let { env = Env { env_top = hsc_env,
-                            env_um  = uniq_mask,
+                            env_ut  = uniq_tag,
                             env_gbl = gbl_env,
                             env_lcl = lcl_env} }
 
@@ -717,14 +717,14 @@
 newUnique :: TcRnIf gbl lcl Unique
 newUnique
  = do { env <- getEnv
-      ; let mask = env_um env
-      ; liftIO $! uniqFromMask mask }
+      ; let tag = env_ut env
+      ; liftIO $! uniqFromTag tag }
 
 newUniqueSupply :: TcRnIf gbl lcl UniqSupply
 newUniqueSupply
  = do { env <- getEnv
-      ; let mask = env_um env
-      ; liftIO $! mkSplitUniqSupply mask }
+      ; let tag = env_ut env
+      ; liftIO $! mkSplitUniqSupply tag }
 
 cloneLocalName :: Name -> TcM Name
 -- Make a fresh Internal name with the same OccName and SrcSpan
diff --git a/compiler/GHC/ThToHs.hs b/compiler/GHC/ThToHs.hs
--- a/compiler/GHC/ThToHs.hs
+++ b/compiler/GHC/ThToHs.hs
@@ -63,6 +63,7 @@
 import Data.List.NonEmpty( NonEmpty (..), nonEmpty )
 import qualified Data.List.NonEmpty as NE
 import Data.Maybe( catMaybes, isNothing )
+import Data.Word (Word64)
 import Language.Haskell.TH as TH hiding (sigP)
 import Language.Haskell.TH.Syntax as TH
 import Foreign.ForeignPtr
@@ -2199,7 +2200,7 @@
 mk_pkg :: TH.PkgName -> Unit
 mk_pkg pkg = stringToUnit (TH.pkgString pkg)
 
-mk_uniq :: Int -> Unique
+mk_uniq :: Word64 -> Unique
 mk_uniq u = mkUniqueGrimily u
 
 {-
diff --git a/compiler/GHC/Utils/Unique.hs b/compiler/GHC/Utils/Unique.hs
new file mode 100644
--- /dev/null
+++ b/compiler/GHC/Utils/Unique.hs
@@ -0,0 +1,35 @@
+{-# LANGUAGE CPP #-}
+
+{- Work around #23537
+
+On 32 bit systems, GHC's codegen around 64 bit numbers is not quite
+complete. This led to panics mentioning missing cases in iselExpr64.
+Now that GHC uses Word64 for its uniques, these panics have started
+popping up whenever a unique is compared to many other uniques in one
+function. As a workaround we use these two functions which are not
+inlined on 32 bit systems, thus preventing the panics.
+-}
+
+module GHC.Utils.Unique (sameUnique, anyOfUnique) where
+
+#include "MachDeps.h"
+
+import GHC.Prelude.Basic (Bool, Eq((==)), Foldable(elem))
+import GHC.Types.Unique (Unique, Uniquable (getUnique))
+
+
+#if WORD_SIZE_IN_BITS == 32
+{-# NOINLINE sameUnique #-}
+#else
+{-# INLINE sameUnique #-}
+#endif
+sameUnique :: Uniquable a => a -> a -> Bool
+sameUnique x y = getUnique x == getUnique y
+
+#if WORD_SIZE_IN_BITS == 32
+{-# NOINLINE anyOfUnique #-}
+#else
+{-# INLINE anyOfUnique #-}
+#endif
+anyOfUnique :: Uniquable a => a -> [Unique] -> Bool
+anyOfUnique tc xs = getUnique tc `elem` xs
diff --git a/ghc-lib.cabal b/ghc-lib.cabal
--- a/ghc-lib.cabal
+++ b/ghc-lib.cabal
@@ -1,7 +1,7 @@
 cabal-version: 3.0
 build-type: Simple
 name: ghc-lib
-version: 9.8.3.20241103
+version: 9.8.4.20241130
 license: BSD-3-Clause
 license-file: LICENSE
 category: Development
@@ -78,10 +78,10 @@
     build-depends:
         base >= 4.17 && < 4.20,
         ghc-prim > 0.2 && < 0.12,
-        containers >= 0.6.2.1 && < 0.7,
+        containers >= 0.6.2.1 && < 0.8,
         bytestring >= 0.11.4 && < 0.13,
-        time >= 1.4 && < 1.13,
-        filepath >= 1 && < 1.5,
+        time >= 1.4 && < 1.15,
+        filepath >= 1.5 && < 1.6,
         exceptions == 0.10.*,
         parsec,
         binary == 0.8.*,
@@ -95,8 +95,8 @@
         semaphore-compat,
         rts,
         hpc >= 0.6 && < 0.8,
-        ghc-lib-parser == 9.8.3.20241103
-    build-tool-depends: alex:alex >= 3.1, happy:happy == 1.20.* || >= 2.0.2 && < 2.1
+        ghc-lib-parser == 9.8.4.20241130
+    build-tool-depends: alex:alex >= 3.1, happy:happy == 1.20.* || == 2.0.2 || >= 2.1.2 && < 2.2
     other-extensions:
         BangPatterns
         CPP
@@ -250,6 +250,13 @@
         GHC.Data.StringBuffer,
         GHC.Data.TrieMap,
         GHC.Data.Unboxed,
+        GHC.Data.Word64Map,
+        GHC.Data.Word64Map.Internal,
+        GHC.Data.Word64Map.Lazy,
+        GHC.Data.Word64Map.Strict,
+        GHC.Data.Word64Map.Strict.Internal,
+        GHC.Data.Word64Set,
+        GHC.Data.Word64Set.Internal,
         GHC.Driver.Backend,
         GHC.Driver.Backend.Internal,
         GHC.Driver.Backpack.Syntax,
@@ -490,6 +497,8 @@
         GHC.Utils.BufHandle,
         GHC.Utils.CliOption,
         GHC.Utils.Constants,
+        GHC.Utils.Containers.Internal.BitUtil,
+        GHC.Utils.Containers.Internal.StrictPair,
         GHC.Utils.Encoding,
         GHC.Utils.Encoding.UTF8,
         GHC.Utils.Error,
@@ -511,6 +520,7 @@
         GHC.Utils.Ppr.Colour,
         GHC.Utils.TmpFs,
         GHC.Utils.Trace,
+        GHC.Utils.Word64,
         GHC.Version,
         GHCi.BreakArray,
         GHCi.FFI,
@@ -923,6 +933,7 @@
         GHC.Unit.Finder
         GHC.Utils.Asm
         GHC.Utils.Monad.Codensity
+        GHC.Utils.Unique
         GHC.Wasm.ControlFlow
         GHC.Wasm.ControlFlow.FromCmm
         GHCi.BinaryArray
diff --git a/ghc-lib/stage0/compiler/build/primop-strictness.hs-incl b/ghc-lib/stage0/compiler/build/primop-strictness.hs-incl
--- a/ghc-lib/stage0/compiler/build/primop-strictness.hs-incl
+++ b/ghc-lib/stage0/compiler/build/primop-strictness.hs-incl
@@ -11,7 +11,7 @@
 primOpStrictness MaskAsyncExceptionsOp =  \ _arity -> mkClosedDmdSig [strictOnceApply1Dmd,topDmd] topDiv 
 primOpStrictness MaskUninterruptibleOp =  \ _arity -> mkClosedDmdSig [strictOnceApply1Dmd,topDmd] topDiv 
 primOpStrictness UnmaskAsyncExceptionsOp =  \ _arity -> mkClosedDmdSig [strictOnceApply1Dmd,topDmd] topDiv 
-primOpStrictness PromptOp =  \ _arity -> mkClosedDmdSig [topDmd, strictOnceApply1Dmd, topDmd] topDiv 
+primOpStrictness PromptOp =  \ _arity -> mkClosedDmdSig [topDmd, lazyApply1Dmd, topDmd] topDiv 
 primOpStrictness Control0Op =  \ _arity -> mkClosedDmdSig [topDmd, lazyApply2Dmd, topDmd] topDiv 
 primOpStrictness AtomicallyOp =  \ _arity -> mkClosedDmdSig [strictManyApply1Dmd,topDmd] topDiv 
 primOpStrictness RetryOp =  \ _arity -> mkClosedDmdSig [topDmd] botDiv 
