diff --git a/CHANGES.markdown b/CHANGES.markdown
--- a/CHANGES.markdown
+++ b/CHANGES.markdown
@@ -1,3 +1,7 @@
+Changes in 0.25.0.1
+  - Discard `--interactive` from response files.  This fixes a critical bug
+    introduced with `0.25.0` (see #487).
+
 Changes in 0.25.0
   - Full GHC 9.14 compatibility / `-unit`-support
 
diff --git a/doctest.cabal b/doctest.cabal
--- a/doctest.cabal
+++ b/doctest.cabal
@@ -5,7 +5,7 @@
 -- see: https://github.com/sol/hpack
 
 name:           doctest
-version:        0.25.0
+version:        0.25.0.1
 synopsis:       Test interactive Haskell examples
 description:    `doctest` is a tool that checks [examples](https://www.haskell.org/haddock/doc/html/ch03s08.html#idm140354810775744)
                 and [properties](https://www.haskell.org/haddock/doc/html/ch03s08.html#idm140354810771856)
diff --git a/src/Cabal/ReplOptions.hs b/src/Cabal/ReplOptions.hs
--- a/src/Cabal/ReplOptions.hs
+++ b/src/Cabal/ReplOptions.hs
@@ -32,6 +32,7 @@
   , Option "libdir" Nothing (Argument "DIR") "installation directory for libraries"
   , Option "libsubdir" Nothing (Argument "DIR") "subdirectory of libdir in which libs are installed"
   , Option "dynlibdir" Nothing (Argument "DIR") "installation directory for dynamic libraries"
+  , Option "bytecodelibdir" Nothing (Argument "DIR") "installation directory for bytecode libraries"
   , Option "libexecdir" Nothing (Argument "DIR") "installation directory for program executables"
   , Option "libexecsubdir" Nothing (Argument "DIR") "subdirectory of libexecdir in which private executables are installed"
   , Option "datadir" Nothing (Argument "DIR") "installation directory for read-only data"
@@ -50,6 +51,8 @@
   , Option "disable-shared" Nothing NoArgument "Disable Shared library"
   , Option "enable-static" Nothing NoArgument "Enable Static library"
   , Option "disable-static" Nothing NoArgument "Disable Static library"
+  , Option "enable-library-bytecode" Nothing NoArgument "Enable Bytecode library"
+  , Option "disable-library-bytecode" Nothing NoArgument "Disable Bytecode library"
   , Option "enable-executable-dynamic" Nothing NoArgument "Enable Executable dynamic linking"
   , Option "disable-executable-dynamic" Nothing NoArgument "Disable Executable dynamic linking"
   , Option "enable-executable-static" Nothing NoArgument "Enable Executable fully static linking"
@@ -184,6 +187,7 @@
   , Option "project-dir" Nothing (Argument "DIR") "Set the path of the project directory"
   , Option "project-file" Nothing (Argument "FILE") "Set the path of the cabal.project file (relative to the project directory when relative)"
   , Option "ignore-project" (Just 'z') NoArgument "Ignore local project configuration (unless --project-dir or --project-file is also set)"
+  , Option "project-file-parser" Nothing (Argument "PARSER") "Set the parser to use for the project file"
   , Option "repl-no-load" Nothing NoArgument "Disable loading of project modules at REPL startup."
   , Option "repl-options" Nothing (Argument "FLAG") "Use the option(s) for the repl"
   , Option "repl-multi-file" Nothing (Argument "DIR") "Write repl options to this directory rather than starting repl mode"
diff --git a/src/GhcUtil.hs b/src/GhcUtil.hs
--- a/src/GhcUtil.hs
+++ b/src/GhcUtil.hs
@@ -27,6 +27,8 @@
 import           GHC.ResponseFile (expandResponse)
 import           System.Exit (exitFailure)
 
+import           Options (discardInteractiveFlag)
+
 -- Catch GHC source errors, print them and exit.
 handleSrcErrors :: Ghc a -> Ghc a
 handleSrcErrors action' = flip handleSourceError action' $ \err -> do
@@ -36,7 +38,7 @@
 -- | Run a GHC action in Haddock mode
 withGhc :: [String] -> ([String] -> Ghc a) -> IO a
 withGhc flags action = runGhc (Just libdir) $ do
-  liftIO (expandUnits flags) >>= handleDynamicFlags >>= handleSrcErrors . action
+  liftIO (expandUnits flags) >>= handleDynamicFlags . discardInteractiveFlag >>= handleSrcErrors . action
 
 expandUnits :: [String] -> IO [String]
 expandUnits = \ case
diff --git a/src/Options.hs b/src/Options.hs
--- a/src/Options.hs
+++ b/src/Options.hs
@@ -1,10 +1,12 @@
 {-# LANGUAGE CPP #-}
+{-# LANGUAGE LambdaCase #-}
 module Options (
   Result(..)
 , Run(..)
 , Config(..)
 , defaultConfig
 , parseOptions
+, discardInteractiveFlag
 #ifdef TEST
 , defaultRun
 , usage
@@ -71,7 +73,7 @@
 , preserveIt = False
 , failFast = False
 , verbose = False
-, repl = (ghc, ["--interactive"])
+, repl = (ghc, [interactiveFlag])
 }
 
 nonInteractiveGhcOptions :: [String]
@@ -118,17 +120,31 @@
 parseOptions :: [String] -> Result Run
 parseOptions args
   | on "--info" = Output info
-  | on "--interactive" = runRunOptionsParser (discard "--interactive" args) defaultRun $ do
+  | on interactiveFlag = runRunOptionsParser (discardInteractiveFlag args) defaultRun $ do
       commonRunOptions
   | on `any` nonInteractiveGhcOptions = ProxyToGhc args
   | on "--help" = Output usage
   | on "--version" = Output versionInfo
+  | any isResponseFile args = runRunOptionsParser args defaultRun $ do
+      commonRunOptions
   | otherwise = runRunOptionsParser args defaultRun {runMagicMode = True} $ do
       commonRunOptions
       parseFlag "--no-magic" (setMagicMode False)
       parseOptGhc
   where
+    on :: String -> Bool
     on option = option `elem` args
+
+    isResponseFile :: String -> Bool
+    isResponseFile = \ case
+      '@' : _ -> True
+      _ -> False
+
+interactiveFlag :: String
+interactiveFlag = "--interactive"
+
+discardInteractiveFlag :: [String] -> [String]
+discardInteractiveFlag = discard interactiveFlag
 
 type RunOptionsParser = RWS () (Endo Run) [String] ()
 
diff --git a/test/OptionsSpec.hs b/test/OptionsSpec.hs
--- a/test/OptionsSpec.hs
+++ b/test/OptionsSpec.hs
@@ -50,6 +50,12 @@
       it "accepts --fast" $ do
         fastMode . runConfig <$> parseOptions ("--fast" : options) `shouldBe` Result True
 
+    context "with a response file" $ do
+      let options = ["--foo", "@args.rsp", "--bar"]
+
+      it "disables magic mode" $ do
+        runMagicMode <$> parseOptions options `shouldBe` Result False
+
     describe "--no-magic" $ do
       context "without --no-magic" $ do
         it "enables magic mode" $ do