diff --git a/CHANGES.markdown b/CHANGES.markdown
--- a/CHANGES.markdown
+++ b/CHANGES.markdown
@@ -1,3 +1,6 @@
+Changes in 0.24.1
+  - Interpret GHC response files
+
 Changes in 0.24.0
   - cabal-doctest: Add support for cabal-install 3.14.*
 
diff --git a/doctest.cabal b/doctest.cabal
--- a/doctest.cabal
+++ b/doctest.cabal
@@ -5,7 +5,7 @@
 -- see: https://github.com/sol/hpack
 
 name:           doctest
-version:        0.24.0
+version:        0.24.1
 synopsis:       Test interactive Haskell examples
 description:    `doctest` is a tool that checks [examples](https://www.haskell.org/haddock/doc/html/ch03s08.html#idm140354810775744)
                 and [properties](https://www.haskell.org/haddock/doc/html/ch03s08.html#idm140354810771856)
diff --git a/src/Run.hs b/src/Run.hs
--- a/src/Run.hs
+++ b/src/Run.hs
@@ -1,4 +1,5 @@
 {-# LANGUAGE CPP #-}
+{-# LANGUAGE LambdaCase #-}
 module Run (
   doctest
 , doctestWithRepl
@@ -62,7 +63,7 @@
 doctest = doctestWithRepl (repl defaultConfig)
 
 doctestWithRepl :: (String, [String]) -> [String] -> IO ()
-doctestWithRepl repl args0 = case parseOptions args0 of
+doctestWithRepl repl = interpretResponseFile >=> \ args0 -> case parseOptions args0 of
   Options.ProxyToGhc args -> exec Interpreter.ghc args
   Options.Output s -> putStr s
   Options.Result (Run warnings magicMode config) -> do
@@ -82,6 +83,11 @@
         addDistArgs <- getAddDistArgs
         return (addDistArgs $ packageDBArgs ++ expandedArgs)
     doctestWith config{repl, ghcOptions = opts}
+
+interpretResponseFile :: [String] -> IO [String]
+interpretResponseFile = \ case
+  ['@':name] -> lines <$> readFile name
+  args -> return args
 
 -- | Expand a reference to a directory to all .hs and .lhs files within it.
 expandDirs :: String -> IO [String]
diff --git a/test/RunSpec.hs b/test/RunSpec.hs
--- a/test/RunSpec.hs
+++ b/test/RunSpec.hs
@@ -9,6 +9,7 @@
 import qualified Control.Exception as E
 import           System.FilePath
 import           System.Directory (getCurrentDirectory, setCurrentDirectory)
+import           System.IO.Temp (withSystemTempDirectory)
 import           Data.List (isPrefixOf, sort)
 import           Data.Char
 
@@ -35,6 +36,17 @@
 removeLoadedPackageEnvironment = id
 #endif
 
+verboseFibOutput :: String
+verboseFibOutput = unlines [
+    "### Started execution at test/integration/testSimple/Fib.hs:5."
+  , "### example:"
+  , "fib 10"
+  , "### Successful!"
+  , ""
+  , "# Final summary:"
+  , "Examples: 1  Tried: 1  Errors: 0  Failures: 0"
+  ]
+
 spec :: Spec
 spec = do
   describe "doctest" $ do
@@ -70,17 +82,19 @@
         , "Try `doctest --help' for more information."
         ]
 
+    it "interprets GHC response files" $ do
+      withSystemTempDirectory "hspec" $ \ dir -> do
+        let file = dir </> "response-file"
+        writeFile file $ unlines [
+            "--verbose"
+          , "test/integration/testSimple/Fib.hs"
+          ]
+        (r, ()) <- hCapture [stderr] $ doctest ['@':file]
+        removeLoadedPackageEnvironment r `shouldBe` verboseFibOutput
+
     it "prints verbose description of a specification" $ do
       (r, ()) <- hCapture [stderr] $ doctest ["--verbose", "test/integration/testSimple/Fib.hs"]
-      removeLoadedPackageEnvironment r `shouldBe` unlines [
-          "### Started execution at test/integration/testSimple/Fib.hs:5."
-        , "### example:"
-        , "fib 10"
-        , "### Successful!"
-        , ""
-        , "# Final summary:"
-        , "Examples: 1  Tried: 1  Errors: 0  Failures: 0"
-        ]
+      removeLoadedPackageEnvironment r `shouldBe` verboseFibOutput
 
     it "prints verbose description of a property" $ do
       (r, ()) <- hCapture [stderr] $ doctest ["--verbose", "test/integration/property-bool/Foo.hs"]