diff --git a/BioInf/ViennaRNA/Bindings/FFI/CoFold.chs b/BioInf/ViennaRNA/Bindings/FFI/CoFold.chs --- a/BioInf/ViennaRNA/Bindings/FFI/CoFold.chs +++ b/BioInf/ViennaRNA/Bindings/FFI/CoFold.chs @@ -87,7 +87,7 @@ let ar = A.accumArray (const id) 0 ((1,1),(n,n)) $ zip [ (ii,jj) | ii <- [n,n-1..1], jj <- [n,n-1..ii]] (drop 1 $ map unsafeCoerce xs) return (eF, s, ar) -foreign import ccall "co_pf_fold_P" co_pf_fold_p :: CString -> CString -> IO CofoldFPtr +foreign import ccall "co_pf_fold" co_pf_fold_p :: CString -> CString -> IO CofoldFPtr #c cofoldF * co_pf_fold_p (char * inp, char * str) diff --git a/ViennaRNA-bindings.cabal b/ViennaRNA-bindings.cabal --- a/ViennaRNA-bindings.cabal +++ b/ViennaRNA-bindings.cabal @@ -1,5 +1,5 @@ name: ViennaRNA-bindings -version: 0.0.3.0 +version: 0.1.0.0 synopsis: ViennaRNA v2 bindings homepage: http://www.tbi.univie.ac.at/~choener/ license: OtherLicense @@ -17,19 +17,46 @@ Only a partial set of bindings is provided. If you need additional functions, please open an issue on github. . - The ViennaRNA package needs to be installed. In addition, you should create a - shared object from libRNA.a: - . - @mkdir tmp; ar -x /usr/lib/libRNA.a; rm svm.o; gcc -shared *.o -o libRNA.so@ - . - Then, copy the resulting .so file into your library path or set - @LD_LIBRARY_PATH@ appropriately. This is only necessary, if you want ghci - support. + The ViennaRNA bindings package now directly provide all necessary + functionality. Please note that this package uses the same license as the + ViennaRNA package. . If you use this software, please cite: R. Lorenz, S.H. Bernhart, C. Hoener zu Siederdissen, H. Tafer, C. Flamm, P.F. Stadler and I.L. Hofacker (2011), "ViennaRNA Package 2.0", Algorithms for Molecular Biology: 6:26 +extra-source-files: + cbits/circfold.inc + include/1.8.4_epars.h + include/1.8.4_intloops.h + include/aln_util.h + include/cofold.h + include/config.h + include/data_structures.h + include/energy_const.h + include/energy_par.h + include/fold.h + include/fold_vars.h + include/gquad.h + include/intl11dH.h + include/intl11.h + include/intl21dH.h + include/intl21.h + include/intl22dH.h + include/intl22.h + include/list.h + include/loop_energies.h + include/naview.h + include/pair_mat.h + include/params.h, + include/part_func_co.h + include/part_func.h + include/plot_layouts.h + include/PS_dot.h + include/subopt.h + include/utils.h + + library exposed-modules: -- public interfaces @@ -46,6 +73,19 @@ build-tools: c2hs extra-libraries: - RNA - gomp + c-sources: + cbits/fold.c + cbits/utils.c + cbits/fold_vars.c + cbits/energy_par.c + cbits/gquad.c + cbits/params.c + cbits/part_func.c + cbits/part_func_co.c + cbits/cofold.c + cc-options: + include-dirs: include + includes: config.h +-- RNA +-- gomp diff --git a/cbits/circfold.inc b/cbits/circfold.inc new file mode 100644 --- /dev/null +++ b/cbits/circfold.inc @@ -0,0 +1,211 @@ +/* -*-C-*- */ +/* this file contains code for folding circular RNAs */ +/* it's #include'd into fold.c */ + +PRIVATE void fill_arrays_circ(const char *string, int *bt){ + /* variant of fold() for circular RNAs */ + /* auxiliarry arrays: + fM2 = multiloop region with exactly two stems, extending to 3' end + for stupid dangles=1 case we also need: + fM_d3 = multiloop region with >= 2 stems, starting at pos 2 + (a pair (k,n) will form 3' dangle with pos 1) + fM_d5 = multiloop region with >= 2 stems, extending to pos n-1 + (a pair (1,k) will form a 5' dangle with pos n) + */ + int Hi, Hj, Ii, Ij, Ip, Iq, Mi; + int *fM_d3, *fM_d5, Md3i, Md5i, FcMd3, FcMd5; + int i,j, p,q,length, energy; + int dangle_model = P->model_details.dangles; + + length = (int) strlen(string); + + FcH = FcI= FcM = FcMd3= FcMd5= Fc = INF; + for (i=1; i max_separation) type = 0; */ /* forces locality degree */ + + type=rtype[type]; + if (!type) continue; + if (no_close) new_c = FORBIDDEN; + else { + char loopseq[10]; + /*int si1, sj1;*/ + if (u<7) { + strcpy(loopseq , string+j-1); + strncat(loopseq, string, i); + } + new_c = E_Hairpin(u, type, S1[j+1], S1[i-1], loopseq, P)+bonus+c[ij]; + } + if (new_cMAXLOOP) break; + qmin = u1+i-1+length-MAXLOOP; + if (qminMAXLOOP) continue; + energy = E_IntLoop(u1, u2, type, type_2, S1[j+1], S1[i-1], S1[p-1], S1[q+1], P); + new_c = c[ij] + c[indx[q]+p] + energy; + if (new_cMLclosing; + if (fmMLclosing; + if (fmMLclosing; + if (fmMLclosing; + if (fmMLclosing; + if (fm0)?Md5i:-Md5i; + sector[(*bt)].ml = 2; + i = (Md5i>0)?Md5i+1 : -Md5i+2; /* let's backtrack fm_d5[Md5i+1] */ + for (u=i+TURN; u0)?Md3i+1:-Md3i+1; + sector[(*bt)].j = length; + sector[(*bt)].ml = 2; + i = (Md3i>0)? Md3i : -Md3i-1; /* let's backtrack fm_d3[Md3i] */ + for (u=2+TURN; u */ +/* + minimum free energy + RNA secondary structure prediction + + c Ivo Hofacker, Chrisoph Flamm + original implementation by + Walter Fontana + + Vienna RNA package +*/ + +#include +#include +#include +#include +#include +#include +#include + +#include "utils.h" +#include "energy_par.h" +#include "fold_vars.h" +#include "pair_mat.h" +#include "params.h" +#include "subopt.h" +#include "fold.h" +#include "loop_energies.h" +#include "gquad.h" +#include "cofold.h" + +#ifdef _OPENMP +#include +#endif + +#define PAREN + +#define STACK_BULGE1 1 /* stacking energies for bulges of size 1 */ +#define NEW_NINIO 1 /* new asymetry penalty */ +#define MAXSECTORS 500 /* dimension for a backtrack array */ +#define LOCALITY 0. /* locality parameter for base-pairs */ +#undef TURN +#define TURN 0 /* reset minimal base pair span for intermolecular pairings */ +#define TURN2 3 /* used by zukersubopt */ +#define SAME_STRAND(I,J) (((I)>=cut_point)||((J)cut) */ +PRIVATE int *fML = NULL; /* multi-loop auxiliary energy array */ +PRIVATE int *fM1 = NULL; /* second ML array, only for subopt */ +PRIVATE int *Fmi = NULL; /* holds row i of fML (avoids jumps in memory) */ +PRIVATE int *DMLi = NULL; /* DMLi[j] holds MIN(fML[i,k]+fML[k+1,j]) */ +PRIVATE int *DMLi1 = NULL; /* MIN(fML[i+1,k]+fML[k+1,j]) */ +PRIVATE int *DMLi2 = NULL; /* MIN(fML[i+2,k]+fML[k+1,j]) */ +PRIVATE char *ptype = NULL; /* precomputed array of pair types */ +PRIVATE short *S = NULL, *S1 = NULL; +PRIVATE paramT *P = NULL; +PRIVATE int init_length = -1; +PRIVATE int zuker = 0; /* Do Zuker style suboptimals? */ +PRIVATE sect sector[MAXSECTORS]; /* stack for backtracking */ +PRIVATE int length; +PRIVATE bondT *base_pair2 = NULL; +PRIVATE int *BP; /* contains the structure constrainsts: BP[i] + -1: | = base must be paired + -2: < = base must be paired with j = base must be paired with j>i + -4: x = base must not pair + positive int: base is paired with int */ +PRIVATE int struct_constrained = 0; +PRIVATE int with_gquad = 0; + +PRIVATE int *ggg = NULL; /* minimum free energies of the gquadruplexes */ + +#ifdef _OPENMP + +#pragma omp threadprivate(mfe1, mfe2, indx, c, cc, cc1, f5, fc, fML, fM1, Fmi, DMLi, DMLi1, DMLi2,\ + ptype, S, S1, P, zuker, sector, length, base_pair2, BP, struct_constrained,\ + ggg, with_gquad) + +#endif + +/* +################################# +# PRIVATE FUNCTION DECLARATIONS # +################################# +*/ + +PRIVATE void init_cofold(int length, paramT *parameters); +PRIVATE void get_arrays(unsigned int size); +/* PRIVATE void scale_parameters(void); */ +PRIVATE void make_ptypes(const short *S, const char *structure); +PRIVATE void backtrack(const char *sequence); +PRIVATE int fill_arrays(const char *sequence); +PRIVATE void free_end(int *array, int i, int start); + +/* +################################# +# BEGIN OF FUNCTION DEFINITIONS # +################################# +*/ + +/*--------------------------------------------------------------------------*/ +PRIVATE void init_cofold(int length, paramT *parameters){ + +#ifdef _OPENMP +/* Explicitly turn off dynamic threads */ + omp_set_dynamic(0); +#endif + + if (length<1) nrerror("init_cofold: argument must be greater 0"); + free_co_arrays(); + get_arrays((unsigned) length); + init_length=length; + + indx = get_indx((unsigned) length); + + update_cofold_params_par(parameters); +} + +/*--------------------------------------------------------------------------*/ + +PRIVATE void get_arrays(unsigned int size){ + if(size >= (unsigned int)sqrt((double)INT_MAX)) + nrerror("get_arrays@cofold.c: sequence length exceeds addressable range"); + + c = (int *) space(sizeof(int)*((size*(size+1))/2+2)); + fML = (int *) space(sizeof(int)*((size*(size+1))/2+2)); + if (uniq_ML) + fM1 = (int *) space(sizeof(int)*((size*(size+1))/2+2)); + + ptype = (char *) space(sizeof(char)*((size*(size+1))/2+2)); + f5 = (int *) space(sizeof(int)*(size+2)); + fc = (int *) space(sizeof(int)*(size+2)); + cc = (int *) space(sizeof(int)*(size+2)); + cc1 = (int *) space(sizeof(int)*(size+2)); + Fmi = (int *) space(sizeof(int)*(size+1)); + DMLi = (int *) space(sizeof(int)*(size+1)); + DMLi1 = (int *) space(sizeof(int)*(size+1)); + DMLi2 = (int *) space(sizeof(int)*(size+1)); + + base_pair2 = (bondT *) space(sizeof(bondT)*(1+size/2)); +} + +/*--------------------------------------------------------------------------*/ + +PUBLIC void free_co_arrays(void){ + if(indx) free(indx); + if(c) free(c); + if(fML) free(fML); + if(f5) free(f5); + if(cc) free(cc); + if(cc1) free(cc1); + if(fc) free(fc); + if(ptype) free(ptype); + if(fM1) free(fM1); + if(base_pair2) free(base_pair2); + if(Fmi) free(Fmi); + if(DMLi) free(DMLi); + if(DMLi1) free(DMLi1); + if(DMLi2) free(DMLi2); + if(P) free(P); + if(ggg) free(ggg); + + indx = c = fML = f5 = cc = cc1 = fc = fM1 = Fmi = DMLi = DMLi1 = DMLi2 = ggg = NULL; + ptype = NULL; + base_pair2 = NULL; + P = NULL; + init_length = 0; +} + + +/*--------------------------------------------------------------------------*/ + +PUBLIC void export_cofold_arrays_gq( int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **fc_p, + int **ggg_p, + int **indx_p, + char **ptype_p){ + + /* make the DP arrays available to routines such as subopt() */ + *f5_p = f5; *c_p = c; + *fML_p = fML; *fM1_p = fM1; + *ggg_p = ggg; + *indx_p = indx; *ptype_p = ptype; + *fc_p =fc; +} + +PUBLIC void export_cofold_arrays( int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **fc_p, + int **indx_p, + char **ptype_p){ + + /* make the DP arrays available to routines such as subopt() */ + *f5_p = f5; *c_p = c; + *fML_p = fML; *fM1_p = fM1; + *indx_p = indx; *ptype_p = ptype; + *fc_p =fc; +} + +/*--------------------------------------------------------------------------*/ + +PUBLIC float cofold(const char *string, char *structure) { + return cofold_par(string, structure, NULL, fold_constrained); +} + +PUBLIC float cofold_par(const char *string, + char *structure, + paramT *parameters, + int is_constrained){ + + int i, length, energy, bonus=0, bonus_cnt=0; + + zuker = 0; + + struct_constrained = is_constrained; + length = (int) strlen(string); + +#ifdef _OPENMP + /* always init everything since all global static variables are uninitialized when entering a thread */ + init_cofold(length, parameters); +#else + if(parameters) init_cofold(length, parameters); + else if (length>init_length) init_cofold(length, parameters); + else if (fabs(P->temperature - temperature)>1e-6) update_cofold_params_par(parameters); +#endif + + with_gquad = P->model_details.gquad; + S = encode_sequence(string, 0); + S1 = encode_sequence(string, 1); + S1[0] = S[0]; /* store length at pos. 0 */ + + BP = (int *)space(sizeof(int)*(length+2)); + if(with_gquad){ /* add a guess of how many G's may be involved in a G quadruplex */ + if(base_pair2) + free(base_pair2); + base_pair2 = (bondT *) space(sizeof(bondT)*(4*(1+length/2))); + } + + make_ptypes(S, structure); + + energy = fill_arrays(string); + + backtrack(string); + +#ifdef PAREN + parenthesis_structure(structure, base_pair2, length); +#else + letter_structure(structure, base_pair2, length); +#endif + + /* + * Backward compatibility: + * This block may be removed if deprecated functions + * relying on the global variable "base_pair" vanish from within the package! + */ + base_pair = base_pair2; + /* + { + if(base_pair) free(base_pair); + base_pair = (bondT *)space(sizeof(bondT) * (1+length/2)); + memcpy(base_pair, base_pair2, sizeof(bondT) * (1+length/2)); + } + */ + + /* check constraints */ + for(i=1;i<=length;i++) { + if((BP[i]<0)&&(BP[i]>-4)) { + bonus_cnt++; + if((BP[i]==-3)&&(structure[i-1]==')')) bonus++; + if((BP[i]==-2)&&(structure[i-1]=='(')) bonus++; + if((BP[i]==-1)&&(structure[i-1]!='.')) bonus++; + } + + if(BP[i]>i) { + int l; + bonus_cnt++; + for(l=1; l<=base_pair2[0].i; l++) + if(base_pair2[l].i != base_pair2[l].j) + if((i==base_pair2[l].i)&&(BP[i]==base_pair2[l].j)) bonus++; + } + } + + if (bonus_cnt>bonus) fprintf(stderr,"\ncould not enforce all constraints\n"); + bonus*=BONUS; + + free(S); free(S1); free(BP); + + energy += bonus; /*remove bonus energies from result */ + + if (backtrack_type=='C') + return (float) c[indx[length]+1]/100.; + else if (backtrack_type=='M') + return (float) fML[indx[length]+1]/100.; + else + return (float) energy/100.; +} + +PRIVATE int fill_arrays(const char *string) { + /* fill "c", "fML" and "f5" arrays and return optimal energy */ + + int i, j, k, length, energy; + int decomp, new_fML, max_separation; + int no_close, type, type_2, tt, maxj; + int bonus=0; + int dangle_model = P->model_details.dangles; + int noGUclosure = P->model_details.noGUclosure; + int noLP = P->model_details.noLP; + + length = (int) strlen(string); + + max_separation = (int) ((1.-LOCALITY)*(double)(length-2)); /* not in use */ + + if(with_gquad) + ggg = get_gquad_matrix(S, P); + + for (j=1; j<=length; j++) { + Fmi[j]=DMLi[j]=DMLi1[j]=DMLi2[j]=INF; + fc[j]=0; + } + + for (j = 1; j<=length; j++) + for (i=1; i<=j; i++) { + c[indx[j]+i] = fML[indx[j]+i] = INF; + if (uniq_ML) fM1[indx[j]+i] = INF; + } + + for (i = length-TURN-1; i >= 1; i--) { /* i,j in [1..length] */ + + maxj=(zuker)? (MIN2(i+cut_point-1,length)):length; + for (j = i+TURN+1; j <= maxj; j++) { + int p, q, ij; + ij = indx[j]+i; + bonus = 0; + type = ptype[ij]; + + /* enforcing structure constraints */ + if ((BP[i]==j)||(BP[i]==-1)||(BP[i]==-2)) bonus -= BONUS; + if ((BP[j]==-1)||(BP[j]==-3)) bonus -= BONUS; + if ((BP[i]==-4)||(BP[j]==-4)) type=0; + + no_close = (((type==3)||(type==4))&&noGUclosure&&(bonus==0)); + + if (j-i-1 > max_separation) type = 0; /* forces locality degree */ + + if (type) { /* we have a pair */ + int new_c=0, stackEnergy=INF; + short si, sj; + si = SAME_STRAND(i, i+1) ? S1[i+1] : -1; + sj = SAME_STRAND(j-1, j) ? S1[j-1] : -1; + /* hairpin ----------------------------------------------*/ + + if (SAME_STRAND(i,j)) { + if (no_close) new_c = FORBIDDEN; + else + new_c = E_Hairpin(j-i-1, type, si, sj, string+i-1, P); + } + else { + if (dangle_model) + new_c += E_ExtLoop(rtype[type], sj, si, P); + else + new_c += E_ExtLoop(rtype[type], -1, -1, P); + } + /*-------------------------------------------------------- + check for elementary structures involving more than one + closing pair. + --------------------------------------------------------*/ + + for (p = i+1; p <= MIN2(j-2-TURN,i+MAXLOOP+1) ; p++) { + int minq = j-i+p-MAXLOOP-2; + if (minqi+1)||(q= 0) && (sj >= 0)){ + decomp = DMLi1[j-1]; + tt = rtype[type]; + MLenergy = P->MLclosing; + switch(dangle_model){ + case 0: MLenergy += decomp + E_MLstem(tt, -1, -1, P); + break; + case 2: MLenergy += decomp + E_MLstem(tt, sj, si, P); + break; + default: decomp += E_MLstem(tt, -1, -1, P); + decomp = MIN2(decomp, DMLi1[j-2] + E_MLstem(tt, sj, -1, P) + P->MLbase); + decomp = MIN2(decomp, DMLi2[j-1] + E_MLstem(tt, -1, si, P) + P->MLbase); + decomp = MIN2(decomp, DMLi2[j-2] + E_MLstem(tt, sj, si, P) + 2*P->MLbase); + MLenergy += decomp; + break; + } + new_c = MIN2(new_c, MLenergy); + } + + if (!SAME_STRAND(i,j)) { /* cut is somewhere in the multiloop*/ + decomp = fc[i+1] + fc[j-1]; + tt = rtype[type]; + switch(dangle_model){ + case 0: decomp += E_ExtLoop(tt, -1, -1, P); + break; + case 2: decomp += E_ExtLoop(tt, sj, si, P); + break; + default: decomp += E_ExtLoop(tt, -1, -1, P); + decomp = MIN2(decomp, fc[i+2] + fc[j-2] + E_ExtLoop(tt, sj, si, P)); + decomp = MIN2(decomp, fc[i+2] + fc[j-1] + E_ExtLoop(tt, -1, si, P)); + decomp = MIN2(decomp, fc[i+1] + fc[j-2] + E_ExtLoop(tt, sj, -1, P)); + break; + } + new_c = MIN2(new_c, decomp); + } + } /* end >> if (!no_close) << */ + + /* coaxial stacking of (i.j) with (i+1.k) or (k+1.j-1) */ + + if (dangle_model==3) { + decomp = INF; + for (k = i+2+TURN; k < j-2-TURN; k++) { + type_2 = ptype[indx[k]+i+1]; type_2 = rtype[type_2]; + if (type_2) + decomp = MIN2(decomp, c[indx[k]+i+1]+P->stack[type][type_2]+ + fML[indx[j-1]+k+1]); + type_2 = ptype[indx[j-1]+k+1]; type_2 = rtype[type_2]; + if (type_2) + decomp = MIN2(decomp, c[indx[j-1]+k+1]+P->stack[type][type_2]+ + fML[indx[k]+i+1]); + } + /* no TermAU penalty if coax stack */ + decomp += 2*P->MLintern[1] + P->MLclosing; + new_c = MIN2(new_c, decomp); + } + + if(with_gquad){ + /* include all cases where a g-quadruplex may be enclosed by base pair (i,j) */ + if (!no_close && SAME_STRAND(i,j)) { + tt = rtype[type]; + energy = E_GQuad_IntLoop(i, j, type, S1, ggg, indx, P); + new_c = MIN2(new_c, energy); + } + } + + new_c = MIN2(new_c, cc1[j-1]+stackEnergy); + cc[j] = new_c + bonus; + if (noLP){ + if (SAME_STRAND(i,i+1) && SAME_STRAND(j-1,j)) + c[ij] = cc1[j-1]+stackEnergy+bonus; + else /* currently we don't allow stacking over the cut point */ + c[ij] = FORBIDDEN; + } + else + c[ij] = cc[j]; + + } /* end >> if (pair) << */ + + else c[ij] = INF; + + + /* done with c[i,j], now compute fML[i,j] */ + /* free ends ? -----------------------------------------*/ + new_fML=INF; + if (SAME_STRAND(i-1,i)) { + if (SAME_STRAND(i,i+1)) new_fML = fML[ij+1]+P->MLbase; + if (SAME_STRAND(j-1,j)) new_fML = MIN2(fML[indx[j-1]+i]+P->MLbase, new_fML); + if (SAME_STRAND(j,j+1)) { + energy = c[ij]; + if(dangle_model == 2) + energy += E_MLstem(type,(i>1) ? S1[i-1] : -1, (jMLbase); + } + } + if (dangle_model%2==1) { /* normal dangles */ + if (SAME_STRAND(i,i+1)) { + tt = ptype[ij+1]; /* i+1,j */ + new_fML = MIN2(new_fML, c[ij+1] + P->MLbase + E_MLstem(tt, S1[i], -1, P)); + } + if (SAME_STRAND(j-1,j)) { + tt = ptype[indx[j-1]+i]; /* i,j-1 */ + new_fML = MIN2(new_fML, c[indx[j-1]+i] + P->MLbase + E_MLstem(tt, -1, S1[j], P)); + } + if ((SAME_STRAND(j-1,j))&&(SAME_STRAND(i,i+1))) { + tt = ptype[indx[j-1]+i+1]; /* i+1,j-1 */ + new_fML = MIN2(new_fML, c[indx[j-1]+i+1] + 2*P->MLbase + E_MLstem(tt, S1[i], S1[j], P)); + } + } + } + + if(with_gquad){ + if(SAME_STRAND(i, j)) + new_fML = MIN2(new_fML, ggg[indx[j] + i] + E_MLstem(0, -1, -1, P)); + } + + /* modular decomposition -------------------------------*/ + + { + int stopp; /*loop 1 up to cut, then loop 2*/ + stopp=(cut_point>0)? (cut_point):(j-2-TURN); + for (decomp=INF, k = i+1+TURN; k0)? (cut_point):(j-2-TURN); + /* additional ML decomposition as two coaxially stacked helices */ + for (decomp = INF, k = i+1+TURN; kstack[type][type_2]); + } + k++; + for (;k <= j-2-TURN; k++) { + type = ptype[indx[k]+i]; type = rtype[type]; + type_2 = ptype[indx[j]+k+1]; type_2 = rtype[type_2]; + if (type && type_2) + decomp = MIN2(decomp, + c[indx[k]+i]+c[indx[j]+k+1]+P->stack[type][type_2]); + } + + decomp += 2*P->MLintern[1]; + +#if 0 + /* This is needed for Y shaped ML loops with coax stacking of + interior pairs, but backtracking will fail if activated */ + DMLi[j] = MIN2(DMLi[j], decomp); + if (SAME_STRAND(j-1,j)) DMLi[j] = MIN2(DMLi[j], DMLi[j-1]+P->MLbase); + if (SAME_STRAND(i,i+1)) DMLi[j] = MIN2(DMLi[j], DMLi1[j]+P->MLbase); + new_fML = MIN2(new_fML, DMLi[j]); +#endif + new_fML = MIN2(new_fML, decomp); + } + + fML[ij] = Fmi[j] = new_fML; /* substring energy */ + + } + + if (i==cut_point) + for (j=i; j<=maxj; j++) + free_end(fc, j, cut_point); + if (i0) { + mfe1=f5[cut_point-1]; + mfe2=fc[length]; + /* add DuplexInit, check whether duplex*/ + for (i=cut_point; i<=length; i++) { + f5[i]=MIN2(f5[i]+P->DuplexInit, fc[i]+fc[1]); + } + } + + energy = f5[length]; + if (cut_point<1) mfe1=mfe2=energy; + return energy; +} + +PRIVATE void backtrack_co(const char *string, int s, int b /* b=0: start new structure, b \ne 0: add to existing structure */) { + + /*------------------------------------------------------------------ + trace back through the "c", "fc", "f5" and "fML" arrays to get the + base pairing list. No search for equivalent structures is done. + This is fast, since only few structure elements are recalculated. + ------------------------------------------------------------------*/ + + int i, j, k, length, energy, new; + int no_close, type, type_2, tt; + int bonus; + int dangle_model = P->model_details.dangles; + int noGUclosure = P->model_details.noGUclosure; + int noLP = P->model_details.noLP; + + /* int b=0;*/ + + length = strlen(string); + if (s==0) { + sector[++s].i = 1; + sector[s].j = length; + sector[s].ml = (backtrack_type=='M') ? 1 : ((backtrack_type=='C')?2:0); + } + while (s>0) { + int ml, fij, fi, cij, traced, i1, j1, mm, p, q, jj=0, gq=0; + int canonical = 1; /* (i,j) closes a canonical structure */ + i = sector[s].i; + j = sector[s].j; + ml = sector[s--].ml; /* ml is a flag indicating if backtracking is to + occur in the fML- (1) or in the f-array (0) */ + if (ml==2) { + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + + if (j < i+TURN+1) continue; /* no more pairs in this interval */ + + + if (ml==0) {fij = f5[j]; fi = f5[j-1];} + else if (ml==1) {fij = fML[indx[j]+i]; fi = fML[indx[j-1]+i]+P->MLbase;} + else /* 3 or 4 */ { + fij = fc[j]; + fi = (ml==3) ? INF : fc[j-1]; + } + if (fij == fi) { /* 3' end is unpaired */ + sector[++s].i = i; + sector[s].j = j-1; + sector[s].ml = ml; + continue; + } + + if (ml==0 || ml==4) { /* backtrack in f5 or fc[i=cut,j>cut] */ + int *ff; + ff = (ml==4) ? fc : f5; + switch(dangle_model){ + case 0: /* j or j-1 is paired. Find pairing partner */ + for (k=j-TURN-1,traced=0; k>=i; k--) { + int cc; + + if(with_gquad){ + if(fij == ff[k-1] + ggg[indx[j]+k]){ + /* found the decomposition */ + traced = j; jj = k - 1; gq = 1; + break; + } + } + + type = ptype[indx[j]+k]; + if(type){ + cc = c[indx[j]+k]; + if(!SAME_STRAND(k,j)) cc += P->DuplexInit; + if(fij == ff[k-1] + cc + E_ExtLoop(type, -1, -1, P)){ + traced = j; jj = k-1; + } + } + if(traced) break; + } + + break; + + case 2: /* j or j-1 is paired. Find pairing partner */ + for (k=j-TURN-1,traced=0; k>=i; k--) { + int cc; + + if(with_gquad){ + if(fij == ff[k-1] + ggg[indx[j]+k]){ + /* found the decomposition */ + traced = j; jj = k - 1; gq = 1; + break; + } + } + + type = ptype[indx[j]+k]; + if(type){ + cc = c[indx[j]+k]; + if(!SAME_STRAND(k,j)) cc += P->DuplexInit; + if(fij == ff[k-1] + cc + E_ExtLoop(type, (k>1) && SAME_STRAND(k-1,k) ? S1[k-1] : -1, (j=i; k--){ + int cc; + type = ptype[indx[j]+k]; + + if(with_gquad){ + if(fij == ff[k-1] + ggg[indx[j]+k]){ + /* found the decomposition */ + traced = j; jj = k - 1; gq = 1; + break; + } + } + + if(type){ + cc = c[indx[j]+k]; + if(!SAME_STRAND(k,j)) cc += P->DuplexInit; + if(fij == ff[k-1] + cc + E_ExtLoop(type, -1, -1, P)){ + traced = j; jj = k-1; break; + } + if((k>1) && SAME_STRAND(k-1,k)) + if(fij == ff[k-2] + cc + E_ExtLoop(type, S1[k-1], -1, P)){ + traced=j; jj=k-2; break; + } + } + + type = ptype[indx[j-1]+k]; + if(type && SAME_STRAND(j-1,j)){ + cc = c[indx[j-1]+k]; + if (!SAME_STRAND(k,j-1)) cc += P->DuplexInit; /*???*/ + if (fij == cc + ff[k-1] + E_ExtLoop(type, -1, S1[j], P)){ + traced=j-1; jj = k-1; break; + } + if(k>i){ + if (fij == ff[k-2] + cc + E_ExtLoop(type, SAME_STRAND(k-1,k) ? S1[k-1] : -1, S1[j], P)){ + traced=j-1; jj=k-2; break; + } + } + } + } + + break; + } + if (!traced) nrerror("backtrack failed in f5 (or fc)"); + sector[++s].i = i; + sector[s].j = jj; + sector[s].ml = ml; + + i=k; j=traced; + + if(with_gquad && gq){ + /* goto backtrace of gquadruplex */ + goto repeat_gquad; + } + + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + else if (ml==3) { /* backtrack in fc[i1 && SAME_STRAND(i-1,i)) ? S1[i-1] : -1, SAME_STRAND(k,k+1) ? S1[k+1] : -1, P)){ + traced = i; + } + } else if (with_gquad){ + if(fc[i] == fc[k+1] + ggg[indx[k]+i]){ + traced = i; gq = 1; + break; + } + } + if (traced) break; + } + break; + default: for(k=i+TURN+1, traced=0; k<=j; k++){ + jj=k+1; + type = ptype[indx[k]+i]; + if(type){ + if(fc[i] == fc[k+1] + c[indx[k]+i] + E_ExtLoop(type, -1, -1, P)){ + traced = i; break; + } + else if(fc[i] == fc[k+2] + c[indx[k]+i] + E_ExtLoop(type, -1, SAME_STRAND(k,k+1) ? S1[k+1] : -1, P)){ + traced = i; jj=k+2; break; + } + } else if (with_gquad){ + if(fc[i] == fc[k+1] + ggg[indx[k]+i]){ + traced = i; gq = 1; + break; + } + } + + type = ptype[indx[k]+i+1]; + if(type){ + if(fc[i] == fc[k+1] + c[indx[k]+i+1] + E_ExtLoop(type, SAME_STRAND(i, i+1) ? S1[i] : -1, -1, P)){ + traced = i+1; break; + } + if(kMLbase == fij) { /* 5' end is unpaired */ + sector[++s].i = i+1; + sector[s].j = j; + sector[s].ml = ml; + continue; + } + + if(with_gquad){ + if(fij == ggg[indx[j]+i] + E_MLstem(0, -1, -1, P)){ + /* go to backtracing of quadruplex */ + goto repeat_gquad; + } + } + + tt = ptype[indx[j]+i]; + cij = c[indx[j]+i]; + switch(dangle_model){ + case 0: if(fij == cij + E_MLstem(tt, -1, -1, P)){ + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + break; + case 2: if(fij == cij + E_MLstem(tt, (i>1) ? S1[i-1] : -1, (jMLbase + E_MLstem(tt, S1[i], -1, P)){ + i++; + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + tt = ptype[indx[j-1]+i]; + if(fij == c[indx[j-1]+i] + P->MLbase + E_MLstem(tt, -1, S1[j], P)){ + j--; + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + tt = ptype[indx[j-1]+i+1]; + if(fij == c[indx[j-1]+i+1] + 2*P->MLbase + E_MLstem(tt, S1[i], S1[j], P)){ + i++; j--; + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + break; + } + + /* find next component of multiloop */ + for (k = i+1+TURN; k <= j-2-TURN; k++) + if (fij == (fML[indx[k]+i]+fML[indx[j]+k+1])) + break; + + if ((dangle_model==3)&&(k>j-2-TURN)) { /* must be coax stack */ + ml = 2; + for (k = i+1+TURN; k <= j-2-TURN; k++) { + type = ptype[indx[k]+i]; type= rtype[type]; + type_2 = ptype[indx[j]+k+1]; type_2= rtype[type_2]; + if (type && type_2) + if (fij == c[indx[k]+i]+c[indx[j]+k+1]+P->stack[type][type_2]+ + 2*P->MLintern[1]) + break; + } + } + + sector[++s].i = i; + sector[s].j = k; + sector[s].ml = ml; + sector[++s].i = k+1; + sector[s].j = j; + sector[s].ml = ml; + + if (k>j-2-TURN) nrerror("backtrack failed in fML"); + continue; + } + + repeat1: + + /*----- begin of "repeat:" -----*/ + if (canonical) cij = c[indx[j]+i]; + type = ptype[indx[j]+i]; + + bonus = 0; + + if ((BP[i]==j)||(BP[i]==-1)||(BP[i]==-2)) bonus -= BONUS; + if ((BP[j]==-1)||(BP[j]==-3)) bonus -= BONUS; + + if (noLP) + if (cij == c[indx[j]+i]) { + /* (i.j) closes canonical structures, thus + (i+1.j-1) must be a pair */ + type_2 = ptype[indx[j-1]+i+1]; type_2 = rtype[type_2]; + cij -= P->stack[type][type_2] + bonus; + base_pair2[++b].i = i+1; + base_pair2[b].j = j-1; + i++; j--; + canonical=0; + goto repeat1; + } + canonical = 1; + + + no_close = (((type==3)||(type==4))&&noGUclosure&&(bonus==0)); + if (SAME_STRAND(i,j)) { + if (no_close) { + if (cij == FORBIDDEN) continue; + } else + if (cij == E_Hairpin(j-i-1, type, S1[i+1], S1[j-1],string+i-1, P)+bonus) + continue; + } + else { + if(dangle_model){ + if(cij == E_ExtLoop(rtype[type], SAME_STRAND(j-1,j) ? S1[j-1] : -1, SAME_STRAND(i,i+1) ? S1[i+1] : -1, P)) continue; + } + else if(cij == E_ExtLoop(rtype[type], -1, -1, P)) continue; + } + + for (p = i+1; p <= MIN2(j-2-TURN,i+MAXLOOP+1); p++) { + int minq; + minq = j-i+p-MAXLOOP-2; + if (minq= minq; q--) { + + type_2 = ptype[indx[q]+p]; + if (type_2==0) continue; + type_2 = rtype[type_2]; + if (noGUclosure) + if (no_close||(type_2==3)||(type_2==4)) + if ((p>i+1)||(qMLclosing; + sector[s+1].ml = sector[s+2].ml = 1; + int ml0 = E_MLstem(tt, -1, -1, P); + int ml5 = E_MLstem(tt, SAME_STRAND(j-1,j) ? S1[j-1] : -1, -1, P); + int ml3 = E_MLstem(tt, -1, SAME_STRAND(i,i+1) ? S1[i+1] : -1, P); + int ml53 = E_MLstem(tt, SAME_STRAND(j-1,j) ? S1[j-1] : -1, SAME_STRAND(i,i+1) ? S1[i+1] : -1, P); + for (traced = 0, k = i+2+TURN; k < j-2-TURN; k++) { + switch(dangle_model){ + case 0: /* no dangles */ + if(cij == mm + fML[indx[k]+i+1] + fML[indx[j-1]+k+1] + ml0) + traced = i+1; + break; + case 2: /*double dangles */ + if(cij == mm + fML[indx[k]+i+1] + fML[indx[j-1]+k+1] + ml53) + traced = i+1; + break; + default: /* normal dangles */ + if(cij == mm + fML[indx[k]+i+1] + fML[indx[j-1]+k+1] + ml0){ + traced = i+1; + break; + } + else if (cij == fML[indx[k]+i+2] + fML[indx[j-1]+k+1] + ml3 + mm + P->MLbase){ + traced = i1 = i+2; + break; + } + else if (cij == fML[indx[k]+i+1] + fML[indx[j-2]+k+1] + ml5 + mm + P->MLbase){ + traced = i1 = i+1; j1 = j-2; + break; + } + else if (cij == fML[indx[k]+i+2] + fML[indx[j-2]+k+1] + ml53 + mm + 2*P->MLbase){ + traced = i1 = i+2; j1 = j-2; + break; + } + break; + } + if(traced) break; + /* coaxial stacking of (i.j) with (i+1.k) or (k.j-1) */ + /* use MLintern[1] since coax stacked pairs don't get TerminalAU */ + if (dangle_model==3) { + int en; + type_2 = ptype[indx[k]+i+1]; type_2 = rtype[type_2]; + if (type_2) { + en = c[indx[k]+i+1]+P->stack[type][type_2]+fML[indx[j-1]+k+1]; + if (cij == en+2*P->MLintern[1]+P->MLclosing) { + ml = 2; + sector[s+1].ml = 2; + break; + } + } + type_2 = ptype[indx[j-1]+k+1]; type_2 = rtype[type_2]; + if (type_2) { + en = c[indx[j-1]+k+1]+P->stack[type][type_2]+fML[indx[k]+i+1]; + if (cij == en+2*P->MLintern[1]+P->MLclosing) { + sector[s+2].ml = 2; + break; + } + } + } + } + if (k<=j-3-TURN) { /* found the decomposition */ + sector[++s].i = i1; + sector[s].j = k; + sector[++s].i = k+1; + sector[s].j = j1; + } else { +#if 0 + /* Y shaped ML loops don't work yet */ + if (dangle_model==3) { + /* (i,j) must close a Y shaped ML loop with coax stacking */ + if (cij == fML[indx[j-2]+i+2] + mm + d3 + d5 + P->MLbase + P->MLbase) { + i1 = i+2; + j1 = j-2; + } else if (cij == fML[indx[j-2]+i+1] + mm + d5 + P->MLbase) + j1 = j-2; + else if (cij == fML[indx[j-1]+i+2] + mm + d3 + P->MLbase) + i1 = i+2; + else /* last chance */ + if (cij != fML[indx[j-1]+i+1] + mm + P->MLbase) + fprintf(stderr, "backtracking failed in repeat"); + /* if we arrive here we can express cij via fML[i1,j1]+dangles */ + sector[++s].i = i1; + sector[s].j = j1; + } + else +#endif + nrerror("backtracking failed in repeat"); + } + + continue; /* this is a workarround to not accidentally proceed in the following block */ + + repeat_gquad: + /* + now we do some fancy stuff to backtrace the stacksize and linker lengths + of the g-quadruplex that should reside within position i,j + */ + { + int l[3], L, a; + L = -1; + + get_gquad_pattern_mfe(S, i, j, P, &L, l); + if(L != -1){ + /* fill the G's of the quadruplex into base_pair2 */ + for(a=0;a> while (s>0) << */ + + base_pair2[0].i = b; /* save the total number of base pairs */ +} + +PRIVATE void free_end(int *array, int i, int start) { + int inc, type, energy, length, j, left, right; + int dangle_model = P->model_details.dangles; + + inc = (i>start)? 1:-1; + length = S[0]; + + if (i==start) array[i]=0; + else array[i] = array[i-inc]; + if (inc>0) { + left = start; right=i; + } else { + left = i; right = start; + } + + for (j=start; inc*(i-j)>TURN; j+=inc) { + int ii, jj; + short si, sj; + if (i>j) { ii = j; jj = i;} /* inc>0 */ + else { ii = i; jj = j;} /* inc<0 */ + type = ptype[indx[jj]+ii]; + if (type) { /* i is paired with j */ + si = (ii>1) && SAME_STRAND(ii-1,ii) ? S1[ii-1] : -1; + sj = (jj 0){ + if(j > left) + array[i] = MIN2(array[i], array[j-2] + energy + E_ExtLoop(type, si, -1, P)); + } + else if(j < right) + array[i] = MIN2(array[i], array[j+2] + energy + E_ExtLoop(type, -1, sj, P)); + break; + } + } + + if(with_gquad){ + if(SAME_STRAND(ii, jj)) + array[i] = MIN2(array[i], array[j-inc] + ggg[indx[jj]+ii]); + } + + if (dangle_model%2==1) { + /* interval ends in a dangle (i.e. i-inc is paired) */ + if (i>j) { ii = j; jj = i-1;} /* inc>0 */ + else { ii = i+1; jj = j;} /* inc<0 */ + type = ptype[indx[jj]+ii]; + if (!type) continue; + + si = (ii > left) && SAME_STRAND(ii-1,ii) ? S1[ii-1] : -1; + sj = (jj < right) && SAME_STRAND(jj,jj+1) ? S1[jj+1] : -1; + energy = c[indx[jj]+ii]; + if(inc>0) + array[i] = MIN2(array[i], array[j - inc] + energy + E_ExtLoop(type, -1, sj, P)); + else + array[i] = MIN2(array[i], array[j - inc] + energy + E_ExtLoop(type, si, -1, P)); + if(j!= start){ /* dangle_model on both sides */ + array[i] = MIN2(array[i], array[j-2*inc] + energy + E_ExtLoop(type, si, sj, P)); + } + } + } +} + +PUBLIC void update_cofold_params(void){ + update_cofold_params_par(NULL); +} + +PUBLIC void update_cofold_params_par(paramT *parameters){ + if(P) free(P); + + if(parameters){ + P = get_parameter_copy(parameters); + } else { + model_detailsT md; + set_model_details(&md); + P = get_scaled_parameters(temperature, md); + } + make_pair_matrix(); + if (init_length < 0) init_length=0; +} + +/*---------------------------------------------------------------------------*/ + +PRIVATE void make_ptypes(const short *S, const char *structure) { + int n,i,j,k,l; + int noLP = P->model_details.noLP; + + n=S[0]; + for (k=1; kn) continue; + type = pair[S[i]][S[j]]; + while ((i>=1)&&(j<=n)) { + if ((i>1)&&(jj]+x->i]+c[indx[x->i+length]+x->j]; + ey = c[indx[y->j]+y->i]+c[indx[y->i+length]+y->j]; + if (ex>ey) return 1; + if (exj]+x->i - indx[y->j]+y->i); +} + +PUBLIC SOLUTION *zukersubopt(const char *string) { + return zukersubopt_par(string, NULL); +} + +PUBLIC SOLUTION *zukersubopt_par(const char *string, paramT *parameters){ + +/* Compute zuker suboptimal. Here, we're abusing the cofold() code + "double" sequence, compute dimerarray entries, track back every base pair. + This is slightly wasteful compared to the normal solution */ + + char *doubleseq, *structure, *mfestructure, **todo; + int i, j, counter, num_pairs, psize, p; + float energy; + SOLUTION *zukresults; + bondT *pairlist; + + num_pairs = counter = 0; + zuker = 1; + length = (int)strlen(string); + doubleseq = (char *)space((2*length+1)*sizeof(char)); + mfestructure = (char *) space((unsigned) 2*length+1); + structure = (char *) space((unsigned) 2*length+1); + zukresults = (SOLUTION *)space(((length*(length-1))/2)*sizeof(SOLUTION)); + mfestructure[0] = '\0'; + BP = (int *)space(sizeof(int)*(2*length+2)); + + /* double the sequence */ + strcpy(doubleseq,string); + strcat(doubleseq,string); + cut_point = length + 1; + + /* get mfe and do forward recursion */ +#ifdef _OPENMP + /* always init everything since all global static variables are uninitialized when entering a thread */ + init_cofold(2 * length, parameters); +#else + if(parameters) init_cofold(2 * length, parameters); + else if ((2 * length) > init_length) init_cofold(2 * length, parameters); + else if (fabs(P->temperature - temperature)>1e-6) update_cofold_params_par(parameters); +#endif + + + S = encode_sequence(doubleseq, 0); + S1 = encode_sequence(doubleseq, 1); + S1[0] = S[0]; /* store length at pos. 0 */ + make_ptypes(S, NULL); /* no constraint folding possible (yet?) with zukersubopt */ + + (void)fill_arrays(doubleseq); + + psize = length; + pairlist = (bondT *) space(sizeof(bondT)*(psize+1)); + todo = (char **) space(sizeof(char *)*(length+1)); + for (i=1; i=psize) { + psize = 1.2*psize + 32; + pairlist = xrealloc(pairlist, sizeof(bondT)*(psize+1)); + } + pairlist[num_pairs].i = i; + pairlist[num_pairs++].j = j; + todo[i][j]=1; + } + } + qsort(pairlist, num_pairs, sizeof(bondT), comp_pair); + + for (p=0; plength) x-=length; + if (y>length) y-=length; + if (x>y) { + int temp; + temp=x; x=y; y=temp; + } + todo[x][y] = 0; + } + } + } + /*free zeugs*/ + free(pairlist); + for (i=1; i +#include +#include +#include +#include +#include +#include + +#include "utils.h" +#include "energy_par.h" +#include "fold_vars.h" +#include "pair_mat.h" +#include "params.h" +#include "loop_energies.h" +#include "data_structures.h" +#include "gquad.h" +#include "fold.h" + +#ifdef _OPENMP +#include +#endif + + +#define PAREN +#define STACK_BULGE1 1 /* stacking energies for bulges of size 1 */ +#define NEW_NINIO 1 /* new asymetry penalty */ +#define MAXSECTORS 500 /* dimension for a backtrack array */ +#define LOCALITY 0. /* locality parameter for base-pairs */ + +#define SAME_STRAND(I,J) (((I)>=cut_point)||((J) = base must be paired with j>i + -4: x = base must not pair + positive int: base is paired with int */ +PRIVATE short *pair_table = NULL; /* needed by energy of struct */ +PRIVATE bondT *base_pair2 = NULL; /* this replaces base_pair from fold_vars.c */ +PRIVATE int circular = 0; +PRIVATE int struct_constrained = 0; +PRIVATE int with_gquad = 0; + +PRIVATE int *ggg = NULL; /* minimum free energies of the gquadruplexes */ + +#ifdef _OPENMP + +#pragma omp threadprivate(indx, c, cc, cc1, f5, f53, fML, fM1, fM2, Fmi,\ + DMLi, DMLi1, DMLi2, DMLi_a, DMLi_o, DMLi1_a, DMLi1_o, DMLi2_a, DMLi2_o,\ + Fc, FcH, FcI, FcM,\ + sector, ptype, S, S1, P, init_length, BP, pair_table, base_pair2, circular, struct_constrained,\ + ggg, with_gquad) + +#endif + +/* +################################# +# PRIVATE FUNCTION DECLARATIONS # +################################# +*/ +PRIVATE void get_arrays(unsigned int size); +PRIVATE int stack_energy(int i, const char *string, int verbostiy_level); +PRIVATE int energy_of_extLoop_pt(int i, short *pair_table); +PRIVATE int energy_of_ml_pt(int i, short *pt); +PRIVATE int ML_Energy(int i, int is_extloop); +PRIVATE void make_ptypes(const short *S, const char *structure); +PRIVATE void backtrack(const char *sequence, int s); +PRIVATE int fill_arrays(const char *sequence); +PRIVATE void fill_arrays_circ(const char *string, int *bt); +PRIVATE void init_fold(int length, paramT *parameters); +/* needed by cofold/eval */ +PRIVATE int cut_in_loop(int i); + +/* deprecated functions */ +/*@unused@*/ +int oldLoopEnergy(int i, int j, int p, int q, int type, int type_2); +int LoopEnergy(int n1, int n2, int type, int type_2, int si1, int sj1, int sp1, int sq1); +int HairpinE(int size, int type, int si1, int sj1, const char *string); + + +/* +################################# +# BEGIN OF FUNCTION DEFINITIONS # +################################# +*/ + +/* allocate memory for folding process */ +PRIVATE void init_fold(int length, paramT *parameters){ + +#ifdef _OPENMP +/* Explicitly turn off dynamic threads */ + omp_set_dynamic(0); +#endif + + if (length<1) nrerror("initialize_fold: argument must be greater 0"); + free_arrays(); + get_arrays((unsigned) length); + init_length=length; + + indx = get_indx((unsigned)length); + + update_fold_params_par(parameters); +} + +/*--------------------------------------------------------------------------*/ + +PRIVATE void get_arrays(unsigned int size){ + if(size >= (unsigned int)sqrt((double)INT_MAX)) + nrerror("get_arrays@fold.c: sequence length exceeds addressable range"); + + c = (int *) space(sizeof(int)*((size*(size+1))/2+2)); + fML = (int *) space(sizeof(int)*((size*(size+1))/2+2)); + if (uniq_ML) + fM1 = (int *) space(sizeof(int)*((size*(size+1))/2+2)); + + ptype = (char *)space(sizeof(char)*((size*(size+1))/2+2)); + f5 = (int *) space(sizeof(int)*(size+2)); + f53 = (int *) space(sizeof(int)*(size+2)); + cc = (int *) space(sizeof(int)*(size+2)); + cc1 = (int *) space(sizeof(int)*(size+2)); + Fmi = (int *) space(sizeof(int)*(size+1)); + DMLi = (int *) space(sizeof(int)*(size+1)); + DMLi1 = (int *) space(sizeof(int)*(size+1)); + DMLi2 = (int *) space(sizeof(int)*(size+1)); + + DMLi_a = (int *) space(sizeof(int)*(size+1)); + DMLi_o = (int *) space(sizeof(int)*(size+1)); + DMLi1_a = (int *) space(sizeof(int)*(size+1)); + DMLi1_o = (int *) space(sizeof(int)*(size+1)); + DMLi2_a = (int *) space(sizeof(int)*(size+1)); + DMLi2_o = (int *) space(sizeof(int)*(size+1)); + + base_pair2 = (bondT *) space(sizeof(bondT)*(1+size/2)); + + /* extra array(s) for circfold() */ + if(circular) fM2 = (int *) space(sizeof(int)*(size+2)); +} + +/*--------------------------------------------------------------------------*/ + +PUBLIC void free_arrays(void){ + if(indx) free(indx); + if(c) free(c); + if(fML) free(fML); + if(f5) free(f5); + if(f53) free(f53); + if(cc) free(cc); + if(cc1) free(cc1); + if(ptype) free(ptype); + if(fM1) free(fM1); + if(fM2) free(fM2); + if(base_pair2) free(base_pair2); + if(Fmi) free(Fmi); + if(DMLi) free(DMLi); + if(DMLi1) free(DMLi1); + if(DMLi2) free(DMLi2); + if(DMLi_a) free(DMLi_a); + if(DMLi_o) free(DMLi_o); + if(DMLi1_a) free(DMLi1_a); + if(DMLi1_o) free(DMLi1_o); + if(DMLi2_a) free(DMLi2_a); + if(DMLi2_o) free(DMLi2_o); + if(P) free(P); + if(ggg) free(ggg); + + indx = c = fML = f5 = f53 = cc = cc1 = fM1 = fM2 = Fmi = DMLi = DMLi1 = DMLi2 = ggg = NULL; + DMLi_a = DMLi_o = DMLi1_a = DMLi1_o = DMLi2_a = DMLi2_o = NULL; + ptype = NULL; + base_pair = NULL; + base_pair2 = NULL; + P = NULL; + init_length = 0; +} + +/*--------------------------------------------------------------------------*/ + +PUBLIC void export_fold_arrays( int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p){ + /* make the DP arrays available to routines such as subopt() */ + *f5_p = f5; + *c_p = c; + *fML_p = fML; + *fM1_p = fM1; + *indx_p = indx; + *ptype_p = ptype; +} + +PUBLIC void export_fold_arrays_par( int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p, + paramT **P_p){ + export_fold_arrays(f5_p, c_p, fML_p, fM1_p, indx_p,ptype_p); + *P_p = P; +} + +PUBLIC void export_circfold_arrays( int *Fc_p, + int *FcH_p, + int *FcI_p, + int *FcM_p, + int **fM2_p, + int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p){ + /* make the DP arrays available to routines such as subopt() */ + *f5_p = f5; + *c_p = c; + *fML_p = fML; + *fM1_p = fM1; + *fM2_p = fM2; + *Fc_p = Fc; + *FcH_p = FcH; + *FcI_p = FcI; + *FcM_p = FcM; + *indx_p = indx; + *ptype_p = ptype; +} + +PUBLIC void export_circfold_arrays_par( int *Fc_p, + int *FcH_p, + int *FcI_p, + int *FcM_p, + int **fM2_p, + int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p, + paramT **P_p){ + export_circfold_arrays(Fc_p, FcH_p, FcI_p, FcM_p, fM2_p, f5_p, c_p, fML_p, fM1_p, indx_p, ptype_p); + *P_p = P; +} +/*--------------------------------------------------------------------------*/ + + +PUBLIC float fold(const char *string, char *structure){ + return fold_par(string, structure, NULL, fold_constrained, 0); +} + +PUBLIC float circfold(const char *string, char *structure){ + return fold_par(string, structure, NULL, fold_constrained, 1); +} + +PUBLIC float fold_par(const char *string, + char *structure, + paramT *parameters, + int is_constrained, + int is_circular){ + + int i, length, energy, bonus, bonus_cnt, s; + + bonus = 0; + bonus_cnt = 0; + s = 0; + circular = is_circular; + struct_constrained = is_constrained; + length = (int) strlen(string); + +#ifdef _OPENMP + init_fold(length, parameters); +#else + if (parameters) init_fold(length, parameters); + else if (length>init_length) init_fold(length, parameters); + else if (fabs(P->temperature - temperature)>1e-6) update_fold_params(); +#endif + + with_gquad = P->model_details.gquad; + S = encode_sequence(string, 0); + S1 = encode_sequence(string, 1); + BP = (int *)space(sizeof(int)*(length+2)); + if(with_gquad){ /* add a guess of how many G's may be involved in a G quadruplex */ + if(base_pair2) + free(base_pair2); + base_pair2 = (bondT *) space(sizeof(bondT)*(4*(1+length/2))); + } + + make_ptypes(S, structure); + + energy = fill_arrays(string); + + if(circular){ + fill_arrays_circ(string, &s); + energy = Fc; + } + backtrack(string, s); + +#ifdef PAREN + parenthesis_structure(structure, base_pair2, length); +#else + letter_structure(structure, base_pair2, length); +#endif + + /* + * Backward compatibility: + * This block may be removed if deprecated functions + * relying on the global variable "base_pair" vanishs from within the package! + */ + base_pair = base_pair2; + /* + { + if(base_pair) free(base_pair); + base_pair = (bondT *)space(sizeof(bondT) * (1+length/2)); + memcpy(base_pair, base_pair2, sizeof(bondT) * (1+length/2)); + } + */ + + /* check constraints */ + for(i=1;i<=length;i++) { + if((BP[i]<0)&&(BP[i]>-4)) { + bonus_cnt++; + if((BP[i]==-3)&&(structure[i-1]==')')) bonus++; + if((BP[i]==-2)&&(structure[i-1]=='(')) bonus++; + if((BP[i]==-1)&&(structure[i-1]!='.')) bonus++; + } + + if(BP[i]>i) { + int l; + bonus_cnt++; + for(l=1; l<=base_pair2[0].i; l++) + if(base_pair2[l].i != base_pair2[l].j) + if((i==base_pair2[l].i)&&(BP[i]==base_pair2[l].j)) bonus++; + } + } + + if (bonus_cnt>bonus) fprintf(stderr,"\ncould not enforce all constraints\n"); + bonus*=BONUS; + + free(S); free(S1); free(BP); + + energy += bonus; /*remove bonus energies from result */ + + if (backtrack_type=='C') + return (float) c[indx[length]+1]/100.; + else if (backtrack_type=='M') + return (float) fML[indx[length]+1]/100.; + else + return (float) energy/100.; +} + +/** +*** fill "c", "fML" and "f5" arrays and return optimal energy +**/ +PRIVATE int fill_arrays(const char *string) { + + int i, j, k, length, energy, en, mm5, mm3; + int decomp, new_fML, max_separation; + int no_close, type, type_2, tt; + int bonus=0; + + int dangle_model, noGUclosure, with_gquads; + + dangle_model = P->model_details.dangles; + noGUclosure = P->model_details.noGUclosure; + + length = (int) strlen(string); + + max_separation = (int) ((1.-LOCALITY)*(double)(length-2)); /* not in use */ + + if(with_gquad) + ggg = get_gquad_matrix(S, P); + + + for (j=1; j<=length; j++) { + Fmi[j]=DMLi[j]=DMLi1[j]=DMLi2[j]=INF; + } + + for (j = 1; j<=length; j++) + for (i=(j>TURN?(j-TURN):1); i= 1; i--) { /* i,j in [1..length] */ + + for (j = i+TURN+1; j <= length; j++) { + int p, q, ij, jj, ee; + int minq, maxq, l1, up, c0, c1, c2, c3; + int MLenergy; + ij = indx[j]+i; + bonus = 0; + type = ptype[ij]; + energy = INF; + /* enforcing structure constraints */ + if ((BP[i]==j)||(BP[i]==-1)||(BP[i]==-2)) bonus -= BONUS; + if ((BP[j]==-1)||(BP[j]==-3)) bonus -= BONUS; + if ((BP[i]==-4)||(BP[j]==-4)) type=0; + + no_close = (((type==3)||(type==4))&&noGUclosure&&(bonus==0)); + + if (j-i-1 > max_separation) type = 0; /* forces locality degree */ + + if (type) { /* we have a pair */ + int new_c=0, stackEnergy=INF; + /* hairpin ----------------------------------------------*/ + + new_c = (no_close) ? FORBIDDEN : E_Hairpin(j-i-1, type, S1[i+1], S1[j-1], string+i-1, P); + + /*-------------------------------------------------------- + check for elementary structures involving more than one + closing pair. + --------------------------------------------------------*/ + + for (p = i+1; p <= MIN2(j-2-TURN,i+MAXLOOP+1) ; p++) { + minq = j-i+p-MAXLOOP-2; + if (minqi+1)||(qMLbase); + decomp = MIN2(decomp, DMLi2[j-2] + E_MLstem(tt, S1[j-1], S1[i+1], P) + 2*P->MLbase); + decomp = MIN2(decomp, DMLi1[j-2] + E_MLstem(tt, S1[j-1], -1, P) + P->MLbase); + break; + } + MLenergy = decomp + P->MLclosing; + new_c = MIN2(new_c, MLenergy); + } + + /* coaxial stacking of (i.j) with (i+1.k) or (k+1.j-1) */ + + if (dangle_model==3) { + decomp = INF; + for (k = i+2+TURN; k < j-2-TURN; k++) { + type_2 = rtype[ptype[indx[k]+i+1]]; + if (type_2) + decomp = MIN2(decomp, c[indx[k]+i+1]+P->stack[type][type_2]+fML[indx[j-1]+k+1]); + type_2 = rtype[ptype[indx[j-1]+k+1]]; + if (type_2) + decomp = MIN2(decomp, c[indx[j-1]+k+1]+P->stack[type][type_2]+fML[indx[k]+i+1]); + } + /* no TermAU penalty if coax stack */ + decomp += 2*P->MLintern[1] + P->MLclosing; + new_c = MIN2(new_c, decomp); + } + + if(with_gquad){ + /* include all cases where a g-quadruplex may be enclosed by base pair (i,j) */ + if (!no_close) { + tt = rtype[type]; + energy = E_GQuad_IntLoop(i, j, type, S1, ggg, indx, P); + new_c = MIN2(new_c, energy); + } + } + + new_c = MIN2(new_c, cc1[j-1]+stackEnergy); + cc[j] = new_c + bonus; + if (noLonelyPairs) + c[ij] = cc1[j-1]+stackEnergy+bonus; + else + c[ij] = cc[j]; + + } /* end >> if (pair) << */ + + else c[ij] = INF; + + /* done with c[i,j], now compute fML[i,j] and fM1[i,j] */ + + /* (i,j) + MLstem ? */ + new_fML = INF; + if(type){ + new_fML = c[ij]; + switch(dangle_model){ + case 2: new_fML += E_MLstem(type, (i==1) ? S1[length] : S1[i-1], S1[j+1], P); + break; + default: new_fML += E_MLstem(type, -1, -1, P); + break; + } + } + + if(with_gquad){ + new_fML = MIN2(new_fML, ggg[indx[j] + i] + E_MLstem(0, -1, -1, P)); + } + + if (uniq_ML){ + fM1[ij] = MIN2(fM1[indx[j-1]+i] + P->MLbase, new_fML); + } + + /* free ends ? -----------------------------------------*/ + /* we must not just extend 3'/5' end by unpaired nucleotides if + * dangle_model == 1, this could lead to d5+d3 contributions were + * mismatch must be taken! + */ + switch(dangle_model){ + /* no dangles */ + case 0: new_fML = MIN2(new_fML, fML[ij+1]+P->MLbase); + new_fML = MIN2(fML[indx[j-1]+i]+P->MLbase, new_fML); + break; + + /* double dangles */ + case 2: new_fML = MIN2(new_fML, fML[ij+1]+P->MLbase); + new_fML = MIN2(fML[indx[j-1]+i]+P->MLbase, new_fML); + break; + + /* normal dangles, aka dangle_model = 1 || 3 */ + default: mm5 = ((i>1) || circular) ? S1[i] : -1; + mm3 = ((jMLbase); + new_fML = MIN2(new_fML, fML[indx[j-1]+i] + P->MLbase); + tt = ptype[ij+1]; + if(tt) new_fML = MIN2(new_fML, c[ij+1] + E_MLstem(tt, mm5, -1, P) + P->MLbase); + tt = ptype[indx[j-1]+i]; + if(tt) new_fML = MIN2(new_fML, c[indx[j-1]+i] + E_MLstem(tt, -1, mm3, P) + P->MLbase); + tt = ptype[indx[j-1]+i+1]; + if(tt) new_fML = MIN2(new_fML, c[indx[j-1]+i+1] + E_MLstem(tt, mm5, mm3, P) + 2*P->MLbase); + break; + } + + /* modular decomposition -------------------------------*/ + for (decomp = INF, k = i + 1 + TURN; k <= j - 2 - TURN; k++) + decomp = MIN2(decomp, Fmi[k]+fML[indx[j]+k+1]); + DMLi[j] = decomp; /* store for use in ML decompositon */ + new_fML = MIN2(new_fML,decomp); + + /* coaxial stacking */ + if (dangle_model==3) { + /* additional ML decomposition as two coaxially stacked helices */ + for (decomp = INF, k = i+1+TURN; k <= j-2-TURN; k++) { + type = ptype[indx[k]+i]; type = rtype[type]; + type_2 = ptype[indx[j]+k+1]; type_2 = rtype[type_2]; + if (type && type_2) + decomp = MIN2(decomp, + c[indx[k]+i]+c[indx[j]+k+1]+P->stack[type][type_2]); + } + + decomp += 2*P->MLintern[1]; /* no TermAU penalty if coax stack */ +#if 0 + /* This is needed for Y shaped ML loops with coax stacking of + interior pairts, but backtracking will fail if activated */ + DMLi[j] = MIN2(DMLi[j], decomp); + DMLi[j] = MIN2(DMLi[j], DMLi[j-1]+P->MLbase); + DMLi[j] = MIN2(DMLi[j], DMLi1[j]+P->MLbase); + new_fML = MIN2(new_fML, DMLi[j]); +#endif + new_fML = MIN2(new_fML, decomp); + } + fML[ij] = Fmi[j] = new_fML; /* substring energy */ + + } + + { + int *FF; /* rotate the auxilliary arrays */ + FF = DMLi2; DMLi2 = DMLi1; DMLi1 = DMLi; DMLi = FF; + FF = cc1; cc1=cc; cc=FF; + for (j=1; j<=length; j++) {cc[j]=Fmi[j]=DMLi[j]=INF; } + } + } + + /* calculate energies of 5' and 3' fragments */ + + f5[TURN+1]= 0; + /* duplicated code may be faster than conditions inside loop ;) */ + switch(dangle_model){ + /* dont use dangling end and mismatch contributions at all */ + case 0: for(j=TURN+2; j<=length; j++){ + f5[j] = f5[j-1]; + for (i=j-TURN-1; i>1; i--){ + + if(with_gquad){ + f5[j] = MIN2(f5[j], f5[i-1] + ggg[indx[j]+i]); + } + + type = ptype[indx[j]+i]; + if(!type) continue; + en = c[indx[j]+i]; + f5[j] = MIN2(f5[j], f5[i-1] + en + E_ExtLoop(type, -1, -1, P)); + } + + if(with_gquad){ + f5[j] = MIN2(f5[j], ggg[indx[j]+1]); + } + + type=ptype[indx[j]+1]; + if(!type) continue; + en = c[indx[j]+1]; + f5[j] = MIN2(f5[j], en + E_ExtLoop(type, -1, -1, P)); + } + break; + + /* always use dangles on both sides */ + case 2: for(j=TURN+2; j1; i--){ + + if(with_gquad){ + f5[j] = MIN2(f5[j], f5[i-1] + ggg[indx[j]+i]); + } + + type = ptype[indx[j]+i]; + if(!type) continue; + en = c[indx[j]+i]; + f5[j] = MIN2(f5[j], f5[i-1] + en + E_ExtLoop(type, S1[i-1], S1[j+1], P)); + } + + if(with_gquad){ + f5[j] = MIN2(f5[j], ggg[indx[j]+1]); + } + + type=ptype[indx[j]+1]; + if(!type) continue; + en = c[indx[j]+1]; + f5[j] = MIN2(f5[j], en + E_ExtLoop(type, -1, S1[j+1], P)); + } + f5[length] = f5[length-1]; + for (i=length-TURN-1; i>1; i--){ + + if(with_gquad){ + f5[length] = MIN2(f5[length], f5[i-1] + ggg[indx[length]+i]); + } + + type = ptype[indx[length]+i]; + if(!type) continue; + en = c[indx[length]+i]; + f5[length] = MIN2(f5[length], f5[i-1] + en + E_ExtLoop(type, S1[i-1], -1, P)); + } + + if(with_gquad){ + f5[length] = MIN2(f5[length], ggg[indx[length]+1]); + } + + type=ptype[indx[length]+1]; + if(!type) break; + en = c[indx[length]+1]; + f5[length] = MIN2(f5[length], en + E_ExtLoop(type, -1, -1, P)); + + + break; + + /* normal dangles, aka dangle_model = 1 || 3 */ + default: for(j=TURN+2; j<=length; j++){ + f5[j] = f5[j-1]; + for (i=j-TURN-1; i>1; i--){ + + if(with_gquad){ + f5[j] = MIN2(f5[j], f5[i-1] + ggg[indx[j]+i]); + } + + type = ptype[indx[j]+i]; + if(type){ + en = c[indx[j]+i]; + f5[j] = MIN2(f5[j], f5[i-1] + en + E_ExtLoop(type, -1, -1, P)); + f5[j] = MIN2(f5[j], f5[i-2] + en + E_ExtLoop(type, S1[i-1], -1, P)); + } + type = ptype[indx[j-1]+i]; + if(type){ + en = c[indx[j-1]+i]; + f5[j] = MIN2(f5[j], f5[i-1] + en + E_ExtLoop(type, -1, S1[j], P)); + f5[j] = MIN2(f5[j], f5[i-2] + en + E_ExtLoop(type, S1[i-1], S1[j], P)); + } + } + + if(with_gquad){ + f5[j] = MIN2(f5[j], ggg[indx[j]+1]); + } + + type = ptype[indx[j]+1]; + if(type) f5[j] = MIN2(f5[j], c[indx[j]+1] + E_ExtLoop(type, -1, -1, P)); + type = ptype[indx[j-1]+1]; + if(type) f5[j] = MIN2(f5[j], c[indx[j-1]+1] + E_ExtLoop(type, -1, S1[j], P)); + } + } + return f5[length]; +} + +#include "circfold.inc" + +/** +*** trace back through the "c", "f5" and "fML" arrays to get the +*** base pairing list. No search for equivalent structures is done. +*** This is fast, since only few structure elements are recalculated. +*** +*** normally s=0. +*** If s>0 then s items have been already pushed onto the sector stack +**/ +PRIVATE void backtrack(const char *string, int s) { + int i, j, ij, k, l1, mm5, mm3, length, energy, en, new; + int no_close, type, type_2, tt, minq, maxq, c0, c1, c2, c3; + int bonus; + int b=0; + int dangle_model = P->model_details.dangles; + + length = strlen(string); + if (s==0) { + sector[++s].i = 1; + sector[s].j = length; + sector[s].ml = (backtrack_type=='M') ? 1 : ((backtrack_type=='C')? 2: 0); + } + while (s>0) { + int ml, fij, fi, cij, traced, i1, j1, p, q, jj=0, gq=0; + int canonical = 1; /* (i,j) closes a canonical structure */ + i = sector[s].i; + j = sector[s].j; + ml = sector[s--].ml; /* ml is a flag indicating if backtracking is to + occur in the fML- (1) or in the f-array (0) */ + if (ml==2) { + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + + else if(ml==7) { /* indicates that i,j are enclosing a gquadruplex */ + /* actually, do something here */ + } + + if (j < i+TURN+1) continue; /* no more pairs in this interval */ + + fij = (ml == 1)? fML[indx[j]+i] : f5[j]; + fi = (ml == 1)?(fML[indx[j-1]+i]+P->MLbase): f5[j-1]; + + if (fij == fi) { /* 3' end is unpaired */ + sector[++s].i = i; + sector[s].j = j-1; + sector[s].ml = ml; + continue; + } + + if (ml == 0) { /* backtrack in f5 */ + switch(dangle_model){ + case 0: /* j is paired. Find pairing partner */ + for(k=j-TURN-1,traced=0; k>=1; k--){ + + if(with_gquad){ + if(fij == f5[k-1] + ggg[indx[j]+k]){ + /* found the decomposition */ + traced = j; jj = k - 1; gq = 1; + break; + } + } + + type = ptype[indx[j]+k]; + if(type) + if(fij == E_ExtLoop(type, -1, -1, P) + c[indx[j]+k] + f5[k-1]){ + traced=j; jj = k-1; + break; + } + } + break; + + case 2: mm3 = (j=1; k--){ + + if(with_gquad){ + if(fij == f5[k-1] + ggg[indx[j]+k]){ + /* found the decomposition */ + traced = j; jj = k - 1; gq = 1; + break; + } + } + + type = ptype[indx[j]+k]; + if(type) + if(fij == E_ExtLoop(type, (k>1) ? S1[k-1] : -1, mm3, P) + c[indx[j]+k] + f5[k-1]){ + traced=j; jj = k-1; + break; + } + } + break; + + default: for(traced = 0, k=j-TURN-1; k>1; k--){ + + if(with_gquad){ + if(fij == f5[k-1] + ggg[indx[j]+k]){ + /* found the decomposition */ + traced = j; jj = k - 1; gq = 1; + break; + } + } + + type = ptype[indx[j] + k]; + if(type){ + en = c[indx[j] + k]; + if(fij == f5[k-1] + en + E_ExtLoop(type, -1, -1, P)){ + traced = j; + jj = k-1; + break; + } + if(fij == f5[k-2] + en + E_ExtLoop(type, S1[k-1], -1, P)){ + traced = j; + jj = k-2; + break; + } + } + type = ptype[indx[j-1] + k]; + if(type){ + en = c[indx[j-1] + k]; + if(fij == f5[k-1] + en + E_ExtLoop(type, -1, S1[j], P)){ + traced = j-1; + jj = k-1; + break; + } + if(fij == f5[k-2] + en + E_ExtLoop(type, S1[k-1], S1[j], P)){ + traced = j-1; + jj = k-2; + break; + } + } + } + if(!traced){ + + if(with_gquad){ + if(fij == ggg[indx[j]+1]){ + /* found the decomposition */ + traced = j; jj = 0; gq = 1; + break; + } + } + + type = ptype[indx[j]+1]; + if(type){ + if(fij == c[indx[j]+1] + E_ExtLoop(type, -1, -1, P)){ + traced = j; + jj = 0; + break; + } + } + type = ptype[indx[j-1]+1]; + if(type){ + if(fij == c[indx[j-1]+1] + E_ExtLoop(type, -1, S1[j], P)){ + traced = j-1; + jj = 0; + break; + } + } + } + break; + } + + if (!traced){ + fprintf(stderr, "%s\n", string); + nrerror("backtrack failed in f5"); + } + /* push back the remaining f5 portion */ + sector[++s].i = 1; + sector[s].j = jj; + sector[s].ml = ml; + + /* trace back the base pair found */ + i=k; j=traced; + + if(with_gquad && gq){ + /* goto backtrace of gquadruplex */ + goto repeat_gquad; + } + + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + else { /* trace back in fML array */ + if (fML[indx[j]+i+1]+P->MLbase == fij) { /* 5' end is unpaired */ + sector[++s].i = i+1; + sector[s].j = j; + sector[s].ml = ml; + continue; + } + + ij = indx[j]+i; + + if(with_gquad){ + if(fij == ggg[ij] + E_MLstem(0, -1, -1, P)){ + /* go to backtracing of quadruplex */ + goto repeat_gquad; + } + } + + tt = ptype[ij]; + en = c[ij]; + switch(dangle_model){ + case 0: if(fij == en + E_MLstem(tt, -1, -1, P)){ + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + break; + + case 2: if(fij == en + E_MLstem(tt, S1[i-1], S1[j+1], P)){ + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + break; + + default: if(fij == en + E_MLstem(tt, -1, -1, P)){ + base_pair2[++b].i = i; + base_pair2[b].j = j; + goto repeat1; + } + tt = ptype[ij+1]; + if(fij == c[ij+1] + E_MLstem(tt, S1[i], -1, P) + P->MLbase){ + base_pair2[++b].i = ++i; + base_pair2[b].j = j; + goto repeat1; + } + tt = ptype[indx[j-1]+i]; + if(fij == c[indx[j-1]+i] + E_MLstem(tt, -1, S1[j], P) + P->MLbase){ + base_pair2[++b].i = i; + base_pair2[b].j = --j; + goto repeat1; + } + tt = ptype[indx[j-1]+i+1]; + if(fij == c[indx[j-1]+i+1] + E_MLstem(tt, S1[i], S1[j], P) + 2*P->MLbase){ + base_pair2[++b].i = ++i; + base_pair2[b].j = --j; + goto repeat1; + } + break; + } + + for(k = i + 1 + TURN; k <= j - 2 - TURN; k++) + if(fij == (fML[indx[k]+i]+fML[indx[j]+k+1])) + break; + + if ((dangle_model==3)&&(k > j - 2 - TURN)) { /* must be coax stack */ + ml = 2; + for (k = i+1+TURN; k <= j - 2 - TURN; k++) { + type = rtype[ptype[indx[k]+i]]; + type_2 = rtype[ptype[indx[j]+k+1]]; + if (type && type_2) + if (fij == c[indx[k]+i]+c[indx[j]+k+1]+P->stack[type][type_2]+ + 2*P->MLintern[1]) + break; + } + } + sector[++s].i = i; + sector[s].j = k; + sector[s].ml = ml; + sector[++s].i = k+1; + sector[s].j = j; + sector[s].ml = ml; + + if (k>j-2-TURN) nrerror("backtrack failed in fML"); + continue; + } + + repeat1: + + /*----- begin of "repeat:" -----*/ + ij = indx[j]+i; + if (canonical) cij = c[ij]; + + type = ptype[ij]; + + bonus = 0; + if (struct_constrained) { + if ((BP[i]==j)||(BP[i]==-1)||(BP[i]==-2)) bonus -= BONUS; + if ((BP[j]==-1)||(BP[j]==-3)) bonus -= BONUS; + } + if (noLonelyPairs) + if (cij == c[ij]){ + /* (i.j) closes canonical structures, thus + (i+1.j-1) must be a pair */ + type_2 = ptype[indx[j-1]+i+1]; type_2 = rtype[type_2]; + cij -= P->stack[type][type_2] + bonus; + base_pair2[++b].i = i+1; + base_pair2[b].j = j-1; + i++; j--; + canonical=0; + goto repeat1; + } + canonical = 1; + + + no_close = (((type==3)||(type==4))&&no_closingGU&&(bonus==0)); + if (no_close) { + if (cij == FORBIDDEN) continue; + } else + if (cij == E_Hairpin(j-i-1, type, S1[i+1], S1[j-1],string+i-1, P)+bonus) + continue; + + for (p = i+1; p <= MIN2(j-2-TURN,i+MAXLOOP+1); p++) { + minq = j-i+p-MAXLOOP-2; + if (minq= minq; q--) { + + type_2 = ptype[indx[q]+p]; + if (type_2==0) continue; + type_2 = rtype[type_2]; + if (no_closingGU) + if (no_close||(type_2==3)||(type_2==4)) + if ((p>i+1)||(qMLclosing - bonus; + for(k = i+2+TURN; k < j-2-TURN; k++){ + if(en == fML[indx[k]+i+1] + fML[indx[j-1]+k+1]) + break; + } + break; + + case 2: en = cij - E_MLstem(tt, S1[j-1], S1[i+1], P) - P->MLclosing - bonus; + for(k = i+2+TURN; k < j-2-TURN; k++){ + if(en == fML[indx[k]+i+1] + fML[indx[j-1]+k+1]) + break; + } + break; + + default: for(k = i+2+TURN; k < j-2-TURN; k++){ + en = cij - P->MLclosing - bonus; + if(en == fML[indx[k]+i+1] + fML[indx[j-1]+k+1] + E_MLstem(tt, -1, -1, P)){ + break; + } + else if(en == fML[indx[k]+i+2] + fML[indx[j-1]+k+1] + E_MLstem(tt, -1, S1[i+1], P) + P->MLbase){ + i1 = i+2; + break; + } + else if(en == fML[indx[k]+i+1] + fML[indx[j-2]+k+1] + E_MLstem(tt, S1[j-1], -1, P) + P->MLbase){ + j1 = j-2; + break; + } + else if(en == fML[indx[k]+i+2] + fML[indx[j-2]+k+1] + E_MLstem(tt, S1[j-1], S1[i+1], P) + 2*P->MLbase){ + i1 = i+2; + j1 = j-2; + break; + } + /* coaxial stacking of (i.j) with (i+1.k) or (k.j-1) */ + /* use MLintern[1] since coax stacked pairs don't get TerminalAU */ + if(dangle_model == 3){ + type_2 = rtype[ptype[indx[k]+i+1]]; + if (type_2) { + en = c[indx[k]+i+1]+P->stack[type][type_2]+fML[indx[j-1]+k+1]; + if (cij == en+2*P->MLintern[1]+P->MLclosing) { + ml = 2; + sector[s+1].ml = 2; + traced = 1; + break; + } + } + type_2 = rtype[ptype[indx[j-1]+k+1]]; + if (type_2) { + en = c[indx[j-1]+k+1]+P->stack[type][type_2]+fML[indx[k]+i+1]; + if (cij == en+2*P->MLintern[1]+P->MLclosing) { + sector[s+2].ml = 2; + traced = 1; + break; + } + } + } + } + break; + } + + if (k<=j-3-TURN) { /* found the decomposition */ + sector[++s].i = i1; + sector[s].j = k; + sector[++s].i = k+1; + sector[s].j = j1; + } else { +#if 0 + /* Y shaped ML loops fon't work yet */ + if (dangle_model==3) { + d5 = P->dangle5[tt][S1[j-1]]; + d3 = P->dangle3[tt][S1[i+1]]; + /* (i,j) must close a Y shaped ML loop with coax stacking */ + if (cij == fML[indx[j-2]+i+2] + mm + d3 + d5 + P->MLbase + P->MLbase) { + i1 = i+2; + j1 = j-2; + } else if (cij == fML[indx[j-2]+i+1] + mm + d5 + P->MLbase) + j1 = j-2; + else if (cij == fML[indx[j-1]+i+2] + mm + d3 + P->MLbase) + i1 = i+2; + else /* last chance */ + if (cij != fML[indx[j-1]+i+1] + mm + P->MLbase) + fprintf(stderr, "backtracking failed in repeat"); + /* if we arrive here we can express cij via fML[i1,j1]+dangles */ + sector[++s].i = i1; + sector[s].j = j1; + } + else +#endif + nrerror("backtracking failed in repeat"); + } + + continue; /* this is a workarround to not accidentally proceed in the following block */ + + repeat_gquad: + /* + now we do some fancy stuff to backtrace the stacksize and linker lengths + of the g-quadruplex that should reside within position i,j + */ + { + int l[3], L, a; + L = -1; + + get_gquad_pattern_mfe(S, i, j, P, &L, l); + if(L != -1){ + /* fill the G's of the quadruplex into base_pair2 */ + for(a=0;a 0 && y+1 <= length) { + if (structure[x-2] != ' ' && structure[y] == structure[x-2]) { + structure[x-1] = structure[x-2]; + structure[y-1] = structure[x-1]; + continue; + } + } + if (structure[x] != ' ' && structure[y-2] == structure[x]) { + structure[x-1] = structure[x]; + structure[y-1] = structure[x-1]; + continue; + } + n++; + structure[x-1] = alpha[n-1]; + structure[y-1] = alpha[n-1]; + } +} + +/*---------------------------------------------------------------------------*/ + +PUBLIC void parenthesis_structure(char *structure, bondT *bp, int length){ + int n, k; + + for (n = 0; n < length; structure[n++] = '.'); + structure[length] = '\0'; + + for (k = 1; k <= bp[0].i; k++){ + + if(bp[k].i == bp[k].j){ /* Gquad bonds are marked as bp[i].i == bp[i].j */ + structure[bp[k].i-1] = '+'; + } else { /* the following ones are regular base pairs */ + structure[bp[k].i-1] = '('; + structure[bp[k].j-1] = ')'; + } + } +} + +PUBLIC void parenthesis_zuker(char *structure, bondT *bp, int length){ + int k, i, j, temp; + + for (k = 0; k < length; structure[k++] = '.'); + structure[length] = '\0'; + + for (k = 1; k <= bp[0].i; k++) { + i=bp[k].i; + j=bp[k].j; + if (i>length) i-=length; + if (j>length) j-=length; + if (i>j) { + temp=i; i=j; j=temp; + } + if(i == j){ /* Gquad bonds are marked as bp[i].i == bp[i].j */ + structure[i-1] = '+'; + } else { /* the following ones are regular base pairs */ + structure[i-1] = '('; + structure[j-1] = ')'; + } + } +} + + +/*---------------------------------------------------------------------------*/ + +PUBLIC void update_fold_params(void){ + update_fold_params_par(NULL); +} + +PUBLIC void update_fold_params_par(paramT *parameters){ + if(P) free(P); + if(parameters){ + P = get_parameter_copy(parameters); + } else { + model_detailsT md; + set_model_details(&md); + P = get_scaled_parameters(temperature, md); + } + make_pair_matrix(); + if (init_length < 0) init_length=0; +} + +/*---------------------------------------------------------------------------*/ +PUBLIC float energy_of_structure(const char *string, const char *structure, int verbosity_level){ + return energy_of_struct_par(string, structure, NULL, verbosity_level); +} + +PUBLIC float energy_of_struct_par(const char *string, + const char *structure, + paramT *parameters, + int verbosity_level){ + int energy; + short *ss, *ss1; + + update_fold_params_par(parameters); + + if (strlen(structure)!=strlen(string)) + nrerror("energy_of_struct: string and structure have unequal length"); + + /* save the S and S1 pointers in case they were already in use */ + ss = S; ss1 = S1; + S = encode_sequence(string, 0); + S1 = encode_sequence(string, 1); + + pair_table = make_pair_table(structure); + + energy = energy_of_structure_pt(string, pair_table, S, S1, verbosity_level); + + free(pair_table); + free(S); free(S1); + S=ss; S1=ss1; + return (float) energy/100.; +} + +/* returns a correction term that may be added to the energy retrieved + from energy_of_struct_par() to correct misinterpreted loops. This + correction is necessary since energy_of_struct_par() will forget + about the existance of gquadruplexes and just treat them as unpaired + regions. + + recursive variant +*/ +PRIVATE int en_corr_of_loop_gquad(int i, + int j, + const char *string, + const char *structure, + short *pt, + int *loop_idx, + const short *s1){ + + int pos, energy, p, q, r, s, u, type, type2; + int L, l[3]; + + energy = 0; + q = i; + while((pos = parse_gquad(structure + q-1, &L, l)) > 0){ + q += pos-1; + p = q - 4*L - l[0] - l[1] - l[2] + 1; + if(q > j) break; + /* we've found the first g-quadruplex at position [p,q] */ + energy += E_gquad(L, l, P); + /* check if it's enclosed in a base pair */ + if(loop_idx[p] == 0){ q++; continue; /* g-quad in exterior loop */} + else{ + energy += E_MLstem(0, -1, -1, P); /* do not forget to remove this energy if + the gquad is the only one surrounded by + the enclosing pair + */ + + /* find its enclosing pair */ + int num_elem, num_g, elem_i, elem_j, up_mis; + num_elem = 0; + num_g = 1; + r = p - 1; + up_mis = q - p + 1; + + /* seek for first pairing base located 5' of the g-quad */ + for(r = p - 1; !pt[r] && (r >= i); r--); + if(r < i) nrerror("this should not happen"); + + if(r < pt[r]){ /* found the enclosing pair */ + s = pt[r]; + } else { + num_elem++; + elem_i = pt[r]; + elem_j = r; + r = pt[r]-1 ; + /* seek for next pairing base 5' of r */ + for(; !pt[r] && (r >= i); r--); + if(r < i) nrerror("so nich"); + if(r < pt[r]){ /* found the enclosing pair */ + s = pt[r]; + } else { + /* hop over stems and unpaired nucleotides */ + while((r > pt[r]) && (r >= i)){ + if(pt[r]){ r = pt[r]; num_elem++;} + r--; + } + if(r < i) nrerror("so nich"); + s = pt[r]; /* found the enclosing pair */ + } + } + /* now we have the enclosing pair (r,s) */ + + u = q+1; + /* we know everything about the 5' part of this loop so check the 3' part */ + while(u 0){ + energy += E_gquad(L, l, P) + E_MLstem(0, -1, -1, P); + up_mis += pos; + u += pos; + num_g++; + } + } else { /* we must have found a stem */ + if(!(u < pt[u])) nrerror("wtf!"); + num_elem++; elem_i = u; elem_j = pt[u]; + energy += en_corr_of_loop_gquad(u, pt[u], string, structure, pt, loop_idx, s1); + u = pt[u] + 1; + } + } + if(u!=s) nrerror("what the hell"); + else{ /* we are done since we've found no other 3' structure element */ + switch(num_elem){ + /* g-quad was misinterpreted as hairpin closed by (r,s) */ + case 0: /* if(num_g == 1) + if((p-r-1 == 0) || (s-q-1 == 0)) + nrerror("too few unpaired bases"); + */ + type = pair[s1[r]][s1[s]]; + if(dangles == 2) + energy += P->mismatchI[type][s1[r+1]][s1[s-1]]; + if(type > 2) + energy += P->TerminalAU; + energy += P->internal_loop[s - r - 1 - up_mis]; + energy -= E_MLstem(0, -1, -1, P); + energy -= E_Hairpin(s - r - 1, + type, + s1[r + 1], + s1[s - 1], + string + r - 1, + P); + break; + /* g-quad was misinterpreted as interior loop closed by (r,s) with enclosed pair (elem_i, elem_j) */ + case 1: type = pair[s1[r]][s1[s]]; + type2 = pair[s1[elem_i]][s1[elem_j]]; + energy += P->MLclosing + + E_MLstem(rtype[type], s1[s-1], s1[r+1], P) + + (elem_i - r - 1 + s - elem_j - 1 - up_mis) * P->MLbase + + E_MLstem(type2, s1[elem_i-1], s1[elem_j+1], P); + energy -= E_IntLoop(elem_i - r - 1, + s - elem_j - 1, + type, + rtype[type2], + s1[r + 1], + s1[s - 1], + s1[elem_i - 1], + s1[elem_j + 1], + P); + break; + /* gquad was misinterpreted as unpaired nucleotides in a multiloop */ + default: energy -= (up_mis) * P->MLbase; + break; + } + } + q = s+1; + } + } + return energy; +} + +PUBLIC float +energy_of_gquad_structure(const char *string, + const char *structure, + int verbosity_level){ + + return energy_of_gquad_struct_par(string, structure, NULL, verbosity_level); +} + +PUBLIC float +energy_of_gquad_struct_par( const char *string, + const char *structure, + paramT *parameters, + int verbosity_level){ + + int energy, gge, *loop_idx; + short *ss, *ss1; + + update_fold_params_par(parameters); + + if (strlen(structure)!=strlen(string)) + nrerror("energy_of_struct: string and structure have unequal length"); + + /* save the S and S1 pointers in case they were already in use */ + ss = S; ss1 = S1; + S = encode_sequence(string, 0); + S1 = encode_sequence(string, 1); + + /* the pair_table looses every information about the gquad position + thus we have to find add the energy contributions for each loop + that contains a gquad by ourself, substract all miscalculated + contributions, i.e. loops that actually contain a gquad, from + energy_of_structure_pt() + */ + pair_table = make_pair_table(structure); + energy = energy_of_structure_pt(string, pair_table, S, S1, verbosity_level); + + loop_idx = make_loop_index_pt(pair_table); + gge = en_corr_of_loop_gquad(1, S[0], string, structure, pair_table, loop_idx, S1); + energy += gge; + + free(pair_table); + free(loop_idx); + free(S); free(S1); + S=ss; S1=ss1; + return (float) energy/100.; +} + +PUBLIC int energy_of_structure_pt(const char *string, + short *ptable, + short *s, + short *s1, + int verbosity_level){ + return energy_of_struct_pt_par(string, ptable, s, s1, NULL, verbosity_level); +} + +PUBLIC int energy_of_struct_pt_par( const char *string, + short *ptable, + short *s, + short *s1, + paramT *parameters, + int verbosity_level){ + /* auxiliary function for kinfold, + for most purposes call energy_of_struct instead */ + + int i, length, energy; + short *ss, *ss1; + + update_fold_params_par(parameters); + + pair_table = ptable; + ss = S; + ss1 = S1; + S = s; + S1 = s1; + + length = S[0]; +/* energy = backtrack_type=='M' ? ML_Energy(0, 0) : ML_Energy(0, 1); */ + energy = backtrack_type=='M' ? energy_of_ml_pt(0, ptable) : energy_of_extLoop_pt(0, ptable); + if (verbosity_level>0) + printf("External loop : %5d\n", energy); + for (i=1; i<=length; i++) { + if (pair_table[i]==0) continue; + energy += stack_energy(i, string, verbosity_level); + i=pair_table[i]; + } + for (i=1; !SAME_STRAND(i,length); i++) { + if (!SAME_STRAND(i,pair_table[i])) { + energy+=P->DuplexInit; + break; + } + } + S = ss; + S1 = ss1; + return energy; +} + +PUBLIC float energy_of_circ_structure(const char *string, + const char *structure, + int verbosity_level){ + return energy_of_circ_struct_par(string, structure, NULL, verbosity_level); +} + +PUBLIC float energy_of_circ_struct_par( const char *string, + const char *structure, + paramT *parameters, + int verbosity_level){ + + int i, j, length, energy=0, en0, degree=0, type; + short *ss, *ss1; + + update_fold_params_par(parameters); + + int dangle_model = P->model_details.dangles; + + if (strlen(structure)!=strlen(string)) + nrerror("energy_of_struct: string and structure have unequal length"); + + /* save the S and S1 pointers in case they were already in use */ + ss = S; ss1 = S1; + S = encode_sequence(string, 0); + S1 = encode_sequence(string, 1); + + pair_table = make_pair_table(structure); + + length = S[0]; + + for (i=1; i<=length; i++) { + if (pair_table[i]==0) continue; + degree++; + energy += stack_energy(i, string, verbosity_level); + i=pair_table[i]; + } + + if (degree==0) return 0.; + for (i=1; pair_table[i]==0; i++); + j = pair_table[i]; + type=pair[S[j]][S[i]]; + if (type==0) type=7; + if (degree==1) { + char loopseq[10]; + int u, si1, sj1; + for (i=1; pair_table[i]==0; i++); + u = length-j + i-1; + if (u<7) { + strcpy(loopseq , string+j-1); + strncat(loopseq, string, i); + } + si1 = (i==1)?S1[length] : S1[i-1]; + sj1 = (j==length)?S1[1] : S1[j+1]; + en0 = E_Hairpin(u, type, sj1, si1, loopseq, P); + } else + if (degree==2) { + int p,q, u1,u2, si1, sq1, type_2; + for (p=j+1; pair_table[p]==0; p++); + q=pair_table[p]; + u1 = p-j-1; + u2 = i-1 + length-q; + type_2 = pair[S[q]][S[p]]; + if (type_2==0) type_2=7; + si1 = (i==1)? S1[length] : S1[i-1]; + sq1 = (q==length)? S1[1] : S1[q+1]; + en0 = E_IntLoop(u1, u2, type, type_2, + S1[j+1], si1, S1[p-1], sq1,P); + } else { /* degree > 2 */ + en0 = ML_Energy(0, 0) - P->MLintern[0]; + if (dangle_model) { + int d5, d3; + if (pair_table[1]) { + j = pair_table[1]; + type = pair[S[1]][S[j]]; + if (dangle_model==2) + en0 += P->dangle5[type][S1[length]]; + else { /* dangle_model==1 */ + if (pair_table[length]==0) { + d5 = P->dangle5[type][S1[length]]; + if (pair_table[length-1]!=0) { + int tt; + tt = pair[S[pair_table[length-1]]][S[length-1]]; + d3 = P->dangle3[tt][S1[length]]; + if (d3dangle3[type][S1[1]]; + else { /* dangle_model==1 */ + if (pair_table[1]==0) { + d3 = P->dangle3[type][S1[1]]; + if (pair_table[2]) { + int tt; + tt = pair[S[2]][S[pair_table[2]]]; + d5 = P->dangle5[tt][1]; + if (d50) + printf("External loop : %5d\n", en0); + energy += en0; + /* fprintf(stderr, "ext loop degree %d tot %d\n", degree, energy); */ + free(S); free(S1); + S=ss; S1=ss1; + return (float) energy/100.0; +} + +/*---------------------------------------------------------------------------*/ +PRIVATE int stack_energy(int i, const char *string, int verbosity_level) +{ + /* calculate energy of substructure enclosed by (i,j) */ + int ee, energy = 0; + int j, p, q, type; + + j=pair_table[i]; + type = pair[S[i]][S[j]]; + if (type==0) { + type=7; + if (verbosity_level>=0) + fprintf(stderr,"WARNING: bases %d and %d (%c%c) can't pair!\n", i, j, + string[i-1],string[j-1]); + } + + p=i; q=j; + while (pq)) break; + type_2 = pair[S[q]][S[p]]; + if (type_2==0) { + type_2=7; + if (verbosity_level>=0) + fprintf(stderr,"WARNING: bases %d and %d (%c%c) can't pair!\n", p, q, + string[p-1],string[q-1]); + } + /* energy += LoopEnergy(i, j, p, q, type, type_2); */ + if ( SAME_STRAND(i,p) && SAME_STRAND(q,j) ) + ee = E_IntLoop(p-i-1, j-q-1, type, type_2, S1[i+1], S1[j-1], S1[p-1], S1[q+1],P); + else + ee = energy_of_extLoop_pt(cut_in_loop(i), pair_table); + if (verbosity_level>0) + printf("Interior loop (%3d,%3d) %c%c; (%3d,%3d) %c%c: %5d\n", + i,j,string[i-1],string[j-1],p,q,string[p-1],string[q-1], ee); + energy += ee; + i=p; j=q; type = rtype[type_2]; + } /* end while */ + + /* p,q don't pair must have found hairpin or multiloop */ + + if (p>q) { /* hair pin */ + if (SAME_STRAND(i,j)) + ee = E_Hairpin(j-i-1, type, S1[i+1], S1[j-1], string+i-1, P); + else + ee = energy_of_extLoop_pt(cut_in_loop(i), pair_table); + energy += ee; + if (verbosity_level>0) + printf("Hairpin loop (%3d,%3d) %c%c : %5d\n", + i, j, string[i-1],string[j-1], ee); + + return energy; + } + + /* (i,j) is exterior pair of multiloop */ + while (p0) + printf("Multi loop (%3d,%3d) %c%c : %5d\n", + i,j,string[i-1],string[j-1],ee); + + return energy; +} + +/*---------------------------------------------------------------------------*/ + + + +/** +*** Calculate the energy contribution of +*** stabilizing dangling-ends/mismatches +*** for all stems branching off the exterior +*** loop +**/ +PRIVATE int energy_of_extLoop_pt(int i, short *pair_table) { + int energy, mm5, mm3; + int p, q, q_prev; + int length = (int)pair_table[0]; + + /* helper variables for dangles == 1 case */ + int E3_available; /* energy of 5' part where 5' mismatch is available for current stem */ + int E3_occupied; /* energy of 5' part where 5' mismatch is unavailable for current stem */ + + int dangle_model = P->model_details.dangles; + + /* initialize vars */ + energy = 0; + p = (i==0) ? 1 : i; + q_prev = -1; + + if(dangle_model%2 == 1){ + E3_available = INF; + E3_occupied = 0; + } + + /* seek to opening base of first stem */ + while(p <= length && !pair_table[p]) p++; + + while(p < length){ + int tt; + /* p must have a pairing partner */ + q = (int)pair_table[p]; + /* get type of base pair (p,q) */ + tt = pair[S[p]][S[q]]; + if(tt==0) tt=7; + + switch(dangle_model){ + /* no dangles */ + case 0: energy += E_ExtLoop(tt, -1, -1, P); + break; + /* the beloved double dangles */ + case 2: mm5 = ((SAME_STRAND(p-1,p)) && (p>1)) ? S1[p-1] : -1; + mm3 = ((SAME_STRAND(q,q+1)) && (q1) && !pair_table[p-1]) ? S1[p-1] : -1; + mm3 = ((SAME_STRAND(q,q+1)) && (qmodel_details.dangles; + + if(i >= pt[i]) + nrerror("energy_of_ml_pt: i is not 5' base of a closing pair!"); + + j = (int)pt[i]; + + /* init the variables */ + energy = 0; + p = i+1; + q_prev = i-1; + q_prev2 = i; + + for (x = 0; x <= NBPAIRS; x++) mlintern[x] = P->MLintern[x]; + + /* seek to opening base of first stem */ + while(p <= j && !pair_table[p]) p++; + u = p - i - 1; + + switch(dangle_model){ + case 0: while(p < j){ + /* p must have a pairing partner */ + q = (int)pair_table[p]; + /* get type of base pair (p,q) */ + tt = pair[S[p]][S[q]]; + if(tt==0) tt=7; + energy += E_MLstem(tt, -1, -1, P); + /* seek to the next stem */ + p = q + 1; + q_prev = q_prev2 = q; + while (p <= j && !pair_table[p]) p++; + u += p - q - 1; /* add unpaired nucleotides */ + } + /* now lets get the energy of the enclosing stem */ + type = pair[S[j]][S[i]]; if (type==0) type=7; + energy += E_MLstem(type, -1, -1, P); + break; + + case 2: while(p < j){ + /* p must have a pairing partner */ + q = (int)pair_table[p]; + /* get type of base pair (p,q) */ + tt = pair[S[p]][S[q]]; + if(tt==0) tt=7; + mm5 = (SAME_STRAND(p-1,p)) ? S1[p-1] : -1; + mm3 = (SAME_STRAND(q,q+1)) ? S1[q+1] : -1; + energy += E_MLstem(tt, mm5, mm3, P); + /* seek to the next stem */ + p = q + 1; + q_prev = q_prev2 = q; + while (p <= j && !pair_table[p]) p++; + u += p - q - 1; /* add unpaired nucleotides */ + } + type = pair[S[j]][S[i]]; if (type==0) type=7; + mm5 = ((SAME_STRAND(j-1,j)) && !pair_table[j-1]) ? S1[j-1] : -1; + mm3 = ((SAME_STRAND(i,i+1)) && !pair_table[i+1]) ? S1[i+1] : -1; + energy += E_MLstem(type, S1[j-1], S1[i+1], P); + break; + + case 3: /* we treat helix stacking different */ + for (count=0; count<2; count++) { /* do it twice */ + ld5 = 0; /* 5' dangle energy on prev pair (type) */ + if ( i==0 ) { + j = (unsigned int)pair_table[0]+1; + type = 0; /* no pair */ + } + else { + j = (unsigned int)pair_table[i]; + type = pair[S[j]][S[i]]; if (type==0) type=7; + /* prime the ld5 variable */ + if (SAME_STRAND(j-1,j)) { + ld5 = P->dangle5[type][S1[j-1]]; + if ((p=(unsigned int)pair_table[j-2]) && SAME_STRAND(j-2, j-1)) + if (P->dangle3[pair[S[p]][S[j-2]]][S1[j-1]]q */ + tt = pair[S[p]][S[q]]; if (tt==0) tt=7; + } + + energy += mlintern[tt]; + cx_energy += mlintern[tt]; + + dang5=dang3=0; + if ((SAME_STRAND(p-1,p))&&(p>1)) + dang5=P->dangle5[tt][S1[p-1]]; /* 5'dangle of pq pair */ + if ((SAME_STRAND(i1,i1+1))&&(i1<(unsigned int)S[0])) + dang3 = P->dangle3[type][S1[i1+1]]; /* 3'dangle of previous pair */ + + switch (p-i1-1) { + case 0: /* adjacent helices */ + if (i1!=0){ + if (SAME_STRAND(i1,p)) { + new_cx = energy + P->stack[rtype[type]][rtype[tt]]; + /* subtract 5'dangle and TerminalAU penalty */ + new_cx += -ld5 - mlintern[tt]-mlintern[type]+2*mlintern[1]; + } + ld5=0; + energy = MIN2(energy, cx_energy); + } + break; + case 1: /* 1 unpaired base between helices */ + dang = MIN2(dang3, dang5); + energy = energy +dang; ld5 = dang - dang3; + /* may be problem here: Suppose + cx_energy>energy, cx_energy+dang5MLclosing; + /* logarithmic ML loop energy if logML */ + if(logML && (u>6)) + energy += 6*P->MLbase+(int)(P->lxc*log((double)u/6.)); + else + energy += (u*P->MLbase); + + return energy; +} + +/*---------------------------------------------------------------------------*/ + +PUBLIC int loop_energy(short * ptable, short *s, short *s1, int i) { + /* compute energy of a single loop closed by base pair (i,j) */ + int j, type, p,q, energy; + short *Sold, *S1old, *ptold; + + ptold=pair_table; Sold = S; S1old = S1; + pair_table = ptable; S = s; S1 = s1; + + if (i==0) { /* evaluate exterior loop */ + energy = energy_of_extLoop_pt(0,pair_table); + pair_table=ptold; S=Sold; S1=S1old; + return energy; + } + j = pair_table[i]; + if (j=0) + fprintf(stderr,"WARNING: bases %d and %d (%c%c) can't pair!\n", i, j, + Law_and_Order[S[i]],Law_and_Order[S[j]]); + } + p=i; q=j; + + + while (pair_table[++p]==0); + while (pair_table[--q]==0); + if (p>q) { /* Hairpin */ + char loopseq[8] = ""; + if (SAME_STRAND(i,j)) { + if (j-i-1<7) { + int u; + for (u=0; i+u<=j; u++) loopseq[u] = Law_and_Order[S[i+u]]; + loopseq[u] = '\0'; + } + energy = E_Hairpin(j-i-1, type, S1[i+1], S1[j-1], loopseq, P); + } else { + energy = energy_of_extLoop_pt(cut_in_loop(i), pair_table); + } + } + else if (pair_table[q]!=(short)p) { /* multi-loop */ + int ii; + ii = cut_in_loop(i); + energy = (ii==0) ? energy_of_ml_pt(i, pair_table) : energy_of_extLoop_pt(ii, pair_table); + } + else { /* found interior loop */ + int type_2; + type_2 = pair[S[q]][S[p]]; + if (type_2==0) { + type_2=7; + if (eos_debug>=0) + fprintf(stderr,"WARNING: bases %d and %d (%c%c) can't pair!\n", p, q, + Law_and_Order[S[p]],Law_and_Order[S[q]]); + } + /* energy += LoopEnergy(i, j, p, q, type, type_2); */ + if ( SAME_STRAND(i,p) && SAME_STRAND(q,j) ) + energy = E_IntLoop(p-i-1, j-q-1, type, type_2, + S1[i+1], S1[j-1], S1[p-1], S1[q+1], P); + else + energy = energy_of_extLoop_pt(cut_in_loop(i), pair_table); + } + + pair_table=ptold; S=Sold; S1=S1old; + return energy; +} + +/*---------------------------------------------------------------------------*/ + + +PUBLIC float energy_of_move(const char *string, const char *structure, int m1, int m2) { + int energy; + short *ss, *ss1; + +#ifdef _OPENMP + if(P == NULL) update_fold_params(); +#else + if((init_length<0)||(P==NULL)) update_fold_params(); +#endif + + if (fabs(P->temperature - temperature)>1e-6) update_fold_params(); + + if (strlen(structure)!=strlen(string)) + nrerror("energy_of_struct: string and structure have unequal length"); + + /* save the S and S1 pointers in case they were already in use */ + ss = S; ss1 = S1; + S = encode_sequence(string, 0); + S1 = encode_sequence(string, 1); + + pair_table = make_pair_table(structure); + + energy = energy_of_move_pt(pair_table, S, S1, m1, m2); + + free(pair_table); + free(S); free(S1); + S=ss; S1=ss1; + return (float) energy/100.; +} + +/*---------------------------------------------------------------------------*/ + +PUBLIC int energy_of_move_pt(short *pt, short *s, short *s1, int m1, int m2) { + /*compute change in energy given by move (m1,m2)*/ + int en_post, en_pre, i,j,k,l, len; + + len = pt[0]; + k = (m1>0)?m1:-m1; + l = (m2>0)?m2:-m2; + /* first find the enclosing pair ij) j=pt[j]; /* skip substructure */ + else { + fprintf(stderr, "%d %d %d %d ", m1, m2, j, pt[j]); + nrerror("illegal move or broken pair table in energy_of_move()"); + } + } + i = (j<=len) ? pt[j] : 0; + en_pre = loop_energy(pt, s, s1, i); + en_post = 0; + if (m1<0) { /*it's a delete move */ + en_pre += loop_energy(pt, s, s1, k); + pt[k]=0; + pt[l]=0; + } else { /* insert move */ + pt[k]=l; + pt[l]=k; + en_post += loop_energy(pt, s, s1, k); + } + en_post += loop_energy(pt, s, s1, i); + /* restore pair table */ + if (m1<0) { + pt[k]=l; + pt[l]=k; + } else { + pt[k]=0; + pt[l]=0; + } + return (en_post - en_pre); +} + + + +PRIVATE int cut_in_loop(int i) { + /* walk around the loop; return j pos of pair after cut if + cut_point in loop else 0 */ + int p, j; + p = j = pair_table[i]; + do { + i = pair_table[p]; p = i+1; + while ( pair_table[p]==0 ) p++; + } while (p!=j && SAME_STRAND(i,p)); + return SAME_STRAND(i,p) ? 0 : j; +} + +/*---------------------------------------------------------------------------*/ + +PRIVATE void make_ptypes(const short *S, const char *structure) { + int n,i,j,k,l; + + n=S[0]; + for (k=1; kn) continue; + type = pair[S[i]][S[j]]; + while ((i>=1)&&(j<=n)) { + if ((i>1)&&(ji){ + (*pl)[k].i = i; + (*pl)[k].j = pt[i]; + (*pl)[k].p = pr; + (*pl)[k++].type = 0; + } + } + + gpl = get_plist_gquad_from_db(struc, pr); + for(ptr = gpl; ptr->i != 0; ptr++){ + if (k == n * size - 1){ + n *= 2; + *pl = (plist *)xrealloc(*pl, n * size * sizeof(plist)); + } + (*pl)[k].i = ptr->i; + (*pl)[k].j = ptr->j; + (*pl)[k].p = ptr->p; + (*pl)[k++].type = ptr->type; + } + free(gpl); + + (*pl)[k].i = 0; + (*pl)[k].j = 0; + (*pl)[k].p = 0.; + (*pl)[k++].type = 0.; + free(pt); + *pl = (plist *)xrealloc(*pl, k * sizeof(plist)); +} + + +/*###########################################*/ +/*# deprecated functions below #*/ +/*###########################################*/ + +PUBLIC int HairpinE(int size, int type, int si1, int sj1, const char *string) { + int energy; + + energy = (size <= 30) ? P->hairpin[size] : + P->hairpin[30]+(int)(P->lxc*log((size)/30.)); + + if (tetra_loop){ + if (size == 4) { /* check for tetraloop bonus */ + char tl[7]={0}, *ts; + strncpy(tl, string, 6); + if ((ts=strstr(P->Tetraloops, tl))) + return (P->Tetraloop_E[(ts - P->Tetraloops)/7]); + } + if (size == 6) { + char tl[9]={0}, *ts; + strncpy(tl, string, 8); + if ((ts=strstr(P->Hexaloops, tl))) + return (energy = P->Hexaloop_E[(ts - P->Hexaloops)/9]); + } + if (size == 3) { + char tl[6]={0,0,0,0,0,0}, *ts; + strncpy(tl, string, 5); + if ((ts=strstr(P->Triloops, tl))) { + return (P->Triloop_E[(ts - P->Triloops)/6]); + } + if (type>2) /* neither CG nor GC */ + energy += P->TerminalAU; /* penalty for closing AU GU pair IVOO?? + sind dass jetzt beaunuesse oder mahlnuesse (vorzeichen?)*/ + return energy; + } + } + energy += P->mismatchH[type][si1][sj1]; + + return energy; +} + +/*---------------------------------------------------------------------------*/ + +PUBLIC int oldLoopEnergy(int i, int j, int p, int q, int type, int type_2) { + /* compute energy of degree 2 loop (stack bulge or interior) */ + int n1, n2, m, energy; + n1 = p-i-1; + n2 = j-q-1; + + if (n1>n2) { m=n1; n1=n2; n2=m; } /* so that n2>=n1 */ + + if (n2 == 0) + energy = P->stack[type][type_2]; /* stack */ + + else if (n1==0) { /* bulge */ + energy = (n2<=MAXLOOP)?P->bulge[n2]: + (P->bulge[30]+(int)(P->lxc*log(n2/30.))); + +#if STACK_BULGE1 + if (n2==1) energy+=P->stack[type][type_2]; +#endif + } else { /* interior loop */ + + if ((n1+n2==2)&&(james_rule)) + /* special case for loop size 2 */ + energy = P->int11[type][type_2][S1[i+1]][S1[j-1]]; + else { + energy = (n1+n2<=MAXLOOP)?(P->internal_loop[n1+n2]): + (P->internal_loop[30]+(int)(P->lxc*log((n1+n2)/30.))); + +#if NEW_NINIO + energy += MIN2(MAX_NINIO, (n2-n1)*P->ninio[2]); +#else + m = MIN2(4, n1); + energy += MIN2(MAX_NINIO,((n2-n1)*P->ninio[m])); +#endif + energy += P->mismatchI[type][S1[i+1]][S1[j-1]]+ + P->mismatchI[type_2][S1[q+1]][S1[p-1]]; + } + } + return energy; +} + +/*--------------------------------------------------------------------------*/ + +PUBLIC int LoopEnergy(int n1, int n2, int type, int type_2, + int si1, int sj1, int sp1, int sq1) { + /* compute energy of degree 2 loop (stack bulge or interior) */ + int nl, ns, energy; + + if (n1>n2) { nl=n1; ns=n2;} + else {nl=n2; ns=n1;} + + if (nl == 0) + return P->stack[type][type_2]; /* stack */ + + if (ns==0) { /* bulge */ + energy = (nl<=MAXLOOP)?P->bulge[nl]: + (P->bulge[30]+(int)(P->lxc*log(nl/30.))); + if (nl==1) energy += P->stack[type][type_2]; + else { + if (type>2) energy += P->TerminalAU; + if (type_2>2) energy += P->TerminalAU; + } + return energy; + } + else { /* interior loop */ + if (ns==1) { + if (nl==1) /* 1x1 loop */ + return P->int11[type][type_2][si1][sj1]; + if (nl==2) { /* 2x1 loop */ + if (n1==1) + energy = P->int21[type][type_2][si1][sq1][sj1]; + else + energy = P->int21[type_2][type][sq1][si1][sp1]; + return energy; + } + else { /* 1xn loop */ + energy = (nl+1<=MAXLOOP)?(P->internal_loop[nl+1]): + (P->internal_loop[30]+(int)(P->lxc*log((nl+1)/30.))); + energy += MIN2(MAX_NINIO, (nl-ns)*P->ninio[2]); + energy += P->mismatch1nI[type][si1][sj1]+ + P->mismatch1nI[type_2][sq1][sp1]; + return energy; + } + } + else if (ns==2) { + if(nl==2) { /* 2x2 loop */ + return P->int22[type][type_2][si1][sp1][sq1][sj1];} + else if (nl==3) { /* 2x3 loop */ + energy = P->internal_loop[5]+P->ninio[2]; + energy += P->mismatch23I[type][si1][sj1]+ + P->mismatch23I[type_2][sq1][sp1]; + return energy; + } + + } + { /* generic interior loop (no else here!)*/ + energy = (n1+n2<=MAXLOOP)?(P->internal_loop[n1+n2]): + (P->internal_loop[30]+(int)(P->lxc*log((n1+n2)/30.))); + + energy += MIN2(MAX_NINIO, (nl-ns)*P->ninio[2]); + + energy += P->mismatchI[type][si1][sj1]+ + P->mismatchI[type_2][sq1][sp1]; + } + } + return energy; +} + +PRIVATE int ML_Energy(int i, int is_extloop) { + /* i is the 5'-base of the closing pair (or 0 for exterior loop) + loop is scored as ML if extloop==0 else as exterior loop + + since each helix can coaxially stack with at most one of its + neighbors we need an auxiliarry variable cx_energy + which contains the best energy given that the last two pairs stack. + energy holds the best energy given the previous two pairs do not + stack (i.e. the two current helices may stack) + We don't allow the last helix to stack with the first, thus we have to + walk around the Loop twice with two starting points and take the minimum + */ + + int energy, cx_energy, best_energy=INF; + int i1, j, p, q, u, x, type, count; + int mlintern[NBPAIRS+1], mlclosing, mlbase; + int dangle_model = P->model_details.dangles; + + if (is_extloop) { + for (x = 0; x <= NBPAIRS; x++) + mlintern[x] = P->MLintern[x]-P->MLintern[1]; /* 0 or TerminalAU */ + mlclosing = mlbase = 0; + } else { + for (x = 0; x <= NBPAIRS; x++) mlintern[x] = P->MLintern[x]; + mlclosing = P->MLclosing; mlbase = P->MLbase; + } + + /* as we do not only have dangling end but also mismatch contributions, + ** we do this a bit different to previous implementations + */ + if(is_extloop){ + energy = 0; + i1 = i; + p = i+1; + + int E_mm5_available, E_mm5_occupied; + /* find out if we may have 5' mismatch for the next stem */ + while (p <= (int)pair_table[0] && pair_table[p]==0) p++; + /* get position of pairing partner */ + if(p < (int)pair_table[0]){ + E_mm5_occupied = (p - i - 1 > 0) ? INF : 0; + E_mm5_available = (p - i - 1 > 0) ? 0 : INF; + } + + if(p < (int)pair_table[0]) + do{ + int tt; + /* p must have a pairing partner */ + q = (int)pair_table[p]; + /* get type of base pair (p,q) */ + tt = pair[S[p]][S[q]]; + if(tt==0) tt=7; + + int mm5 = ((SAME_STRAND(p-1,p)) && (p>1)) ? S1[p-1]: -1; + int mm3 = ((SAME_STRAND(q,q+1)) && (q<(unsigned int)pair_table[0])) ? S1[q+1]: -1; + + switch(dangle_model){ + /* dangle_model == 0 */ + case 0: energy += E_ExtLoop(tt, -1, -1, P); + break; + /* dangle_model == 1 */ + case 1: { + /* check for unpaired nucleotide 3' to the current stem */ + int u3 = ((q < pair_table[0]) && (pair_table[q+1] == 0)) ? 1 : 0; + if(pair_table[p-1] != 0) mm5 = -1; + + if(!u3){ + mm3 = -1; + E_mm5_occupied = MIN2( + E_mm5_occupied + E_ExtLoop(tt, -1, -1, P), + E_mm5_available + E_ExtLoop(tt, mm5, -1, P) + ); + E_mm5_available = E_mm5_occupied; + } + else{ + E_mm5_occupied = MIN2( + E_mm5_occupied + E_ExtLoop(tt, -1, mm3, P), + E_mm5_available + E_ExtLoop(tt, mm5, mm3, P) + ); + E_mm5_available = MIN2( + E_mm5_occupied + E_ExtLoop(tt, -1, -1, P), + E_mm5_available + E_ExtLoop(tt, mm5, -1, P) + ); + } + } + break; + + /* the beloved case dangle_model == 2 */ + case 2: energy += E_ExtLoop(tt, mm5, mm3, P); + break; + + /* dangle_model == 3 a.k.a. helix stacking */ + case 3: break; + + } /* end switch dangle_model */ + + /* seek to the next stem */ + p = q + 1; + while (p <= (int)pair_table[0] && pair_table[p]==0) p++; + if(p == (int)pair_table[0] + 1){ + if(dangle_model == 1) + energy = (p > q + 1) ? E_mm5_occupied : E_mm5_available; + q = 0; + break; + } + } while(q != i); + } + /* not exterior loop */ + else{ + for (count=0; count<2; count++) { /* do it twice */ + int ld5 = 0; /* 5' dangle energy on prev pair (type) */ + if ( i==0 ) { + j = (unsigned int)pair_table[0]+1; + type = 0; /* no pair */ + } + else { + j = (unsigned int)pair_table[i]; + type = pair[S[j]][S[i]]; if (type==0) type=7; + + if (dangle_model==3) { /* prime the ld5 variable */ + if (SAME_STRAND(j-1,j)) { + ld5 = P->dangle5[type][S1[j-1]]; + if ((p=(unsigned int)pair_table[j-2]) && SAME_STRAND(j-2, j-1)) + if (P->dangle3[pair[S[p]][S[j-2]]][S1[j-1]]q */ + tt = pair[S[p]][S[q]]; if (tt==0) tt=7; + } + + energy += mlintern[tt]; + cx_energy += mlintern[tt]; + + if (dangle_model) { + int dang5=0, dang3=0, dang; + if ((SAME_STRAND(p-1,p))&&(p>1)) + dang5=P->dangle5[tt][S1[p-1]]; /* 5'dangle of pq pair */ + if ((SAME_STRAND(i1,i1+1))&&(i1<(unsigned int)S[0])) + dang3 = P->dangle3[type][S1[i1+1]]; /* 3'dangle of previous pair */ + + switch (p-i1-1) { + case 0: /* adjacent helices */ + if (dangle_model==2) + energy += dang3+dang5; + else if (dangle_model==3 && i1!=0) { + if (SAME_STRAND(i1,p)) { + new_cx = energy + P->stack[rtype[type]][rtype[tt]]; + /* subtract 5'dangle and TerminalAU penalty */ + new_cx += -ld5 - mlintern[tt]-mlintern[type]+2*mlintern[1]; + } + ld5=0; + energy = MIN2(energy, cx_energy); + } + break; + case 1: /* 1 unpaired base between helices */ + dang = (dangle_model==2)?(dang3+dang5):MIN2(dang3, dang5); + if (dangle_model==3) { + energy = energy +dang; ld5 = dang - dang3; + /* may be problem here: Suppose + cx_energy>energy, cx_energy+dang56) ) + energy += 6*mlbase+(int)(P->lxc*log((double)u/6.)); + else + energy += mlbase*u; + /* fprintf(stderr, "\n"); */ + } + return energy; +} + +PUBLIC void initialize_fold(int length){ + /* DO NOTHING */ +} + +PUBLIC float energy_of_struct(const char *string, const char *structure){ + return energy_of_structure(string, structure, eos_debug); +} + +PUBLIC int energy_of_struct_pt(const char *string, short * ptable, short *s, short *s1){ + return energy_of_structure_pt(string, ptable, s, s1, eos_debug); +} + +PUBLIC float energy_of_circ_struct(const char *string, const char *structure){ + return energy_of_circ_structure(string, structure, eos_debug); +} + diff --git a/cbits/fold_vars.c b/cbits/fold_vars.c new file mode 100644 --- /dev/null +++ b/cbits/fold_vars.c @@ -0,0 +1,88 @@ +/* Last changed Time-stamp: <2008-06-27 17:21:42 ivo> */ + +/** +*** \file fold_vars.c +*** global variables to change behaviour of folding routines
+*** Also there are some functions that make the live easier when +*** using functions of the Vienna RNA package +**/ +#include +#include +#include "fold_vars.h" + +int circ = 0; + +int noGU = 0; /* GU not allowed at all */ + +int no_closingGU = 0; /* GU allowed only inside stacks */ + +int tetra_loop = 1; /* Fold with specially stable 4-loops */ + +int energy_set = 0; /* 0 = BP; 1=any with GC; 2=any with AU parameters */ + +int dangles = 2; /* use dangling end energies */ + +char *nonstandards = (char *)0; /* contains allowed non standard bases */ + +double temperature = 37.0; + +int james_rule = 1; /* interior loops of size 2 get energy 0.8Kcal and + no mismatches (no longer used) */ + +int oldAliEn = 0; /* use old alifold-energies (without removing gaps) */ + +int ribo = 0; /* use ribosum instead of classic covariance term */ + +char *RibosumFile = NULL; /* TODO: compile ribosums into program + Warning: this variable will vanish */ + +int csv = 0; /*generate comma seperated output*/ + +bondT *base_pair = NULL; + +FLT_OR_DBL *pr = NULL; /* base pairing prob. matrix */ + +int *iindx = NULL; /* pr[i,j] -> pr[iindx[i]-j] */ + +double pf_scale = -1; /* scaling factor to avoid floating point overflows */ + +int fold_constrained = 0; /* fold with constraints */ + +int do_backtrack = 1; /* calculate pair prob matrix in part_func() */ + +int noLonelyPairs = 0; /* avoid helices of length 1 */ + +char backtrack_type = 'F'; /* 'C' require (1,N) to be bonded; + 'M' seq is part of s multi loop */ + +int *cut_points; + +int *strand; + +int gquad = 0; /* consider g-qudruplexes in the calculations */ + +PUBLIC char * option_string(void){ + static char options[100]; + *options = '\0'; + if (noGU) strcat(options, "-noGU "); + if (no_closingGU) strcat(options, "-noCloseGU "); + if (!tetra_loop) strcat(options, "-4 "); + if (noLonelyPairs) strcat(options, "-noLP "); + if (fold_constrained) strcat(options, "-C "); + if (dangles!=1) sprintf(options+strlen(options), "-d%d ", dangles); + if (temperature!=37.0) + sprintf(options+strlen(options), "-T %f ", temperature); + return options; +} + +PUBLIC void set_model_details(model_detailsT *md){ + if(md){ + md->dangles = dangles; + md->special_hp = tetra_loop; + md->noLP = noLonelyPairs; + md->noGU = noGU; + md->noGUclosure = no_closingGU; + md->logML = logML; + md->gquad = gquad; + } +} diff --git a/cbits/gquad.c b/cbits/gquad.c new file mode 100644 --- /dev/null +++ b/cbits/gquad.c @@ -0,0 +1,1043 @@ +/* + gquad.c + + Ronny Lorenz 2012 + + Vienna RNA package +*/ + +#include +#include +#include +#include + +#include "config.h" // chzs +#include "fold_vars.h" +#include "data_structures.h" +#include "energy_const.h" +#include "utils.h" +#include "aln_util.h" +#include "gquad.h" + +#ifndef INLINE +#ifdef __GNUC__ +# define INLINE inline +#else +# define INLINE +#endif +#endif + +/** + * Use this macro to loop over each G-quadruplex + * delimited by a and b within the subsequence [c,d] + */ +#define FOR_EACH_GQUAD(a, b, c, d) \ + for((a) = (d) - VRNA_GQUAD_MIN_BOX_SIZE + 1; (a) >= (c); (a)--)\ + for((b) = (a) + VRNA_GQUAD_MIN_BOX_SIZE - 1;\ + (b) <= MIN2((d), (a) + VRNA_GQUAD_MAX_BOX_SIZE - 1);\ + (b)++) + +/** + * This macro does almost the same as FOR_EACH_GQUAD() but keeps + * the 5' delimiter fixed. 'b' is the 3' delimiter of the gquad, + * for gquads within subsequence [a,c] that have 5' delimiter 'a' + */ +#define FOR_EACH_GQUAD_AT(a, b, c) \ + for((b) = (a) + VRNA_GQUAD_MIN_BOX_SIZE - 1;\ + (b) <= MIN2((c), (a) + VRNA_GQUAD_MAX_BOX_SIZE - 1);\ + (b)++) + + +/* +################################# +# PRIVATE FUNCTION DECLARATIONS # +################################# +*/ + +PRIVATE INLINE +int * +get_g_islands(short *S); + +PRIVATE INLINE +int * +get_g_islands_sub(short *S, int i, int j); + +/** + * IMPORTANT: + * If you don't know how to use this function, DONT'T USE IT! + * + * The function pointer this function takes as argument is + * used for individual calculations with each g-quadruplex + * delimited by [i,j]. + * The function it points to always receives as first 3 arguments + * position i, the stack size L and an array l[3] containing the + * individual linker sizes. + * The remaining 4 (void *) pointers of the callback function receive + * the parameters 'data', 'P', 'aux1' and 'aux2' and thus may be + * used to pass whatever data you like to. + * As the names of those parameters suggest the convention is that + * 'data' should be used as a pointer where data is stored into, + * e.g the MFE or PF and the 'P' parameter should actually be a + * 'paramT *' or 'pf_paramT *' type. + * However, what you actually pass obviously depends on the + * function the pointer is pointing to. + * + * Although all of this may look like an overkill, it is found + * to be almost as fast as implementing g-quadruplex enumeration + * in each individual scenario, i.e. code duplication. + * Using this function, however, ensures that all g-quadruplex + * enumerations are absolutely identical. + */ +PRIVATE +void +process_gquad_enumeration(int *gg, + int i, + int j, + void (*f)(int, int, int *, + void *, void *, void *, void *), + void *data, + void *P, + void *aux1, + void *aux2); + +/** + * MFE callback for process_gquad_enumeration() + */ +PRIVATE +void +gquad_mfe(int i, + int L, + int *l, + void *data, + void *P, + void *NA, + void *NA2); + +PRIVATE +void +gquad_mfe_pos(int i, + int L, + int *l, + void *data, + void *P, + void *Lmfe, + void *lmfe); + +PRIVATE +void +gquad_pos_exhaustive( int i, + int L, + int *l, + void *data, + void *P, + void *Lex, + void *lex); + +/** + * Partition function callback for process_gquad_enumeration() + */ +PRIVATE +void +gquad_pf( int i, + int L, + int *l, + void *data, + void *P, + void *NA, + void *NA2); + +/** + * Partition function callback for process_gquad_enumeration() + * in contrast to gquad_pf() it stores the stack size L and + * the linker lengths l[3] of the g-quadruplex that dominates + * the interval [i,j] + * (FLT_OR_DBL *)data must be 0. on entry + */ +PRIVATE +void +gquad_pf_pos( int i, + int L, + int *l, + void *data, + void *pf, + void *Lmax, + void *lmax); + +/** + * MFE (alifold) callback for process_gquad_enumeration() + */ +PRIVATE +void +gquad_mfe_ali(int i, + int L, + int *l, + void *data, + void *P, + void *S, + void *n_seq); + +/** + * MFE (alifold) callback for process_gquad_enumeration() + * with seperation of free energy and penalty contribution + */ +PRIVATE +void +gquad_mfe_ali_en( int i, + int L, + int *l, + void *data, + void *P, + void *S, + void *n_seq); + +PRIVATE +void +gquad_interact( int i, + int L, + int *l, + void *data, + void *pf, + void *index, + void *NA2); + +PRIVATE +void +gquad_count(int i, + int L, + int *l, + void *data, + void *NA, + void *NA2, + void *NA3); + +PRIVATE +void +gquad_count_layers( int i, + int L, + int *l, + void *data, + void *NA, + void *NA2, + void *NA3); + +/* other useful static functions */ + +PRIVATE +int +gquad_ali_penalty(int i, + int L, + int l[3], + const short **S, + paramT *P); + +/* +######################################### +# BEGIN OF PUBLIC FUNCTION DEFINITIONS # +# (all available in RNAlib) # +######################################### +*/ + +/******************************** + Here are the G-quadruplex energy + contribution functions +*********************************/ + +PUBLIC int E_gquad( int L, + int l[3], + paramT *P){ + + int i, c = INF; + + for(i=0;i<3;i++){ + if(l[i] > VRNA_GQUAD_MAX_LINKER_LENGTH) return c; + if(l[i] < VRNA_GQUAD_MIN_LINKER_LENGTH) return c; + } + if(L > VRNA_GQUAD_MAX_STACK_SIZE) return c; + if(L < VRNA_GQUAD_MIN_STACK_SIZE) return c; + + gquad_mfe(0, L, l, + (void *)(&c), + (void *)P, + NULL, + NULL); + return c; +} + +PUBLIC FLT_OR_DBL exp_E_gquad(int L, + int l[3], + pf_paramT *pf){ + + int i; + FLT_OR_DBL q = 0.; + + for(i=0;i<3;i++){ + if(l[i] > VRNA_GQUAD_MAX_LINKER_LENGTH) return q; + if(l[i] < VRNA_GQUAD_MIN_LINKER_LENGTH) return q; + } + if(L > VRNA_GQUAD_MAX_STACK_SIZE) return q; + if(L < VRNA_GQUAD_MIN_STACK_SIZE) return q; + + gquad_pf( 0, L, l, + (void *)(&q), + (void *)pf, + NULL, + NULL); + return q; +} + +PUBLIC int E_gquad_ali( int i, + int L, + int l[3], + const short **S, + int n_seq, + paramT *P){ + + int en[2]; + E_gquad_ali_en(i, L, l, S, n_seq, en, P); + return en[0] + en[1]; +} + + +PUBLIC void E_gquad_ali_en( int i, + int L, + int l[3], + const short **S, + int n_seq, + int en[2], + paramT *P){ + + int j; + en[0] = en[1] = INF; + + for(j=0;j<3;j++){ + if(l[j] > VRNA_GQUAD_MAX_LINKER_LENGTH) return; + if(l[j] < VRNA_GQUAD_MIN_LINKER_LENGTH) return; + } + if(L > VRNA_GQUAD_MAX_STACK_SIZE) return; + if(L < VRNA_GQUAD_MIN_STACK_SIZE) return; + + gquad_mfe_ali_en( i, L, l, + (void *)(&(en[0])), + (void *)P, + (void *)S, + (void *)(&n_seq)); +} + +/******************************** + Now, the triangular matrix + generators for the G-quadruplex + contributions are following +*********************************/ + +PUBLIC int *get_gquad_matrix(short *S, paramT *P){ + + int n, size, i, j, *gg, *my_index, *data; + + n = S[0]; + my_index = get_indx(n); + gg = get_g_islands(S); + size = (n * (n+1))/2 + 2; + data = (int *)space(sizeof(int) * size); + + /* prefill the upper triangular matrix with INF */ + for(i = 0; i < size; i++) data[i] = INF; + + FOR_EACH_GQUAD(i, j, 1, n){ + process_gquad_enumeration(gg, i, j, + &gquad_mfe, + (void *)(&(data[my_index[j]+i])), + (void *)P, + NULL, + NULL); + } + + free(my_index); + free(gg); + return data; +} + +PUBLIC FLT_OR_DBL *get_gquad_pf_matrix( short *S, + FLT_OR_DBL *scale, + pf_paramT *pf){ + + int n, size, *gg, i, j, *my_index; + FLT_OR_DBL *data; + + + n = S[0]; + size = (n * (n+1))/2 + 2; + data = (FLT_OR_DBL *)space(sizeof(FLT_OR_DBL) * size); + gg = get_g_islands(S); + my_index = get_iindx(n); + + FOR_EACH_GQUAD(i, j, 1, n){ + process_gquad_enumeration(gg, i, j, + &gquad_pf, + (void *)(&(data[my_index[i]-j])), + (void *)pf, + NULL, + NULL); + data[my_index[i]-j] *= scale[j-i+1]; + } + + free(my_index); + free(gg); + return data; +} + +PUBLIC int *get_gquad_ali_matrix( short *S_cons, + short **S, + int n_seq, + paramT *P){ + + int n, size, *data, *gg; + int i, j, *my_index; + + + n = S[0][0]; + size = (n * (n+1))/2 + 2; + data = (int *)space(sizeof(int) * size); + gg = get_g_islands(S_cons); + my_index = get_indx(n); + + /* prefill the upper triangular matrix with INF */ + for(i=0;in-maxdist-5) && (k>=0); k--){ + data[k] = (int *) space(sizeof(int)*(maxdist+5)); + for(i = 0; i < maxdist+5; i++) data[k][i] = INF; + } + + /* compute all contributions for the gquads in this interval */ + FOR_EACH_GQUAD(i, j, n - maxdist - 4, n){ + process_gquad_enumeration(gg, i, j, + &gquad_mfe, + (void *)(&(data[i][j-i])), + (void *)P, + NULL, + NULL); + } + } + + gg += start - 1; + free(gg); + return data; +} + +PUBLIC plist *get_plist_gquad_from_db(const char *structure, float pr){ + int x, size, actual_size, L, n, ge, ee, gb, l[3]; + plist *pl; + + actual_size = 0; + ge = 0; + n = 2; + size = strlen(structure); + pl = (plist *)space(n*size*sizeof(plist)); + + while((ee = parse_gquad(structure + ge, &L, l)) > 0){ + ge += ee; + gb = ge - L*4 - l[0] - l[1] - l[2] + 1; + /* add pseudo-base pair encloding gquad */ + for(x = 0; x < L; x++){ + if (actual_size >= n * size - 5){ + n *= 2; + pl = (plist *)xrealloc(pl, n * size * sizeof(plist)); + } + pl[actual_size].i = gb + x; + pl[actual_size].j = ge + x - L + 1; + pl[actual_size].p = pr; + pl[actual_size++].type = 0; + + pl[actual_size].i = gb + x; + pl[actual_size].j = gb + x + l[0] + L; + pl[actual_size].p = pr; + pl[actual_size++].type = 0; + + pl[actual_size].i = gb + x + l[0] + L; + pl[actual_size].j = ge + x - 2*L - l[2] + 1; + pl[actual_size].p = pr; + pl[actual_size++].type = 0; + + pl[actual_size].i = ge + x - 2*L - l[2] + 1; + pl[actual_size].j = ge + x - L + 1; + pl[actual_size].p = pr; + pl[actual_size++].type = 0; + } + } + + pl[actual_size].i = pl[actual_size].j = 0; + pl[actual_size++].p = 0; + pl = (plist *)xrealloc(pl, actual_size * sizeof(plist)); + return pl; +} + +PUBLIC void get_gquad_pattern_mfe(short *S, + int i, + int j, + paramT *P, + int *L, + int l[3]){ + + int *gg = get_g_islands_sub(S, i, j); + int c = INF; + + process_gquad_enumeration(gg, i, j, + &gquad_mfe_pos, + (void *)(&c), + (void *)P, + (void *)L, + (void *)l); + + gg += i - 1; + free(gg); +} + +PUBLIC void +get_gquad_pattern_exhaustive( short *S, + int i, + int j, + paramT *P, + int *L, + int *l, + int threshold){ + + int *gg = get_g_islands_sub(S, i, j); + + process_gquad_enumeration(gg, i, j, + &gquad_pos_exhaustive, + (void *)(&threshold), + (void *)P, + (void *)L, + (void *)l); + + gg += i - 1; + free(gg); +} + +PUBLIC void get_gquad_pattern_pf( short *S, + int i, + int j, + pf_paramT *pf, + int *L, + int l[3]){ + + int *gg = get_g_islands_sub(S, i, j); + FLT_OR_DBL q = 0.; + + process_gquad_enumeration(gg, i, j, + &gquad_pf_pos, + (void *)(&q), + (void *)pf, + (void *)L, + (void *)l); + + gg += i - 1; + free(gg); +} + +PUBLIC plist *get_plist_gquad_from_pr(short *S, + int gi, + int gj, + FLT_OR_DBL *G, + FLT_OR_DBL *probs, + FLT_OR_DBL *scale, + pf_paramT *pf){ + + int L, l[3]; + return get_plist_gquad_from_pr_max(S, gi, gj, G, probs, scale, &L, l, pf); +} + + +PUBLIC plist *get_plist_gquad_from_pr_max(short *S, + int gi, + int gj, + FLT_OR_DBL *G, + FLT_OR_DBL *probs, + FLT_OR_DBL *scale, + int *Lmax, + int lmax[3], + pf_paramT *pf){ + + int n, size, *gg, counter, i, j, *my_index; + FLT_OR_DBL pp, *tempprobs; + plist *pl; + + n = S[0]; + size = (n * (n + 1))/2 + 2; + tempprobs = (FLT_OR_DBL *)space(sizeof(FLT_OR_DBL) * size); + pl = (plist *)space((S[0]*S[0])*sizeof(plist)); + gg = get_g_islands_sub(S, gi, gj); + counter = 0; + my_index = get_iindx(n); + + process_gquad_enumeration(gg, gi, gj, + &gquad_interact, + (void *)tempprobs, + (void *)pf, + (void *)my_index, + NULL); + + pp = 0.; + process_gquad_enumeration(gg, gi, gj, + &gquad_pf_pos, + (void *)(&pp), + (void *)pf, + (void *)Lmax, + (void *)lmax); + + pp = probs[my_index[gi]-gj] * scale[gj-gi+1] / G[my_index[gi]-gj]; + for (i=gi;i0.) { + pl[counter].i=i; + pl[counter].j=j; + pl[counter++].p = pp * tempprobs[my_index[i]-j]; + } + } + } + pl[counter].i = pl[counter].j = 0; + pl[counter++].p = 0.; + /* shrink memory to actual size needed */ + pl = (plist *) xrealloc(pl, counter * sizeof(plist)); + + gg += gi - 1; free(gg); + free(my_index); + free (tempprobs); + return pl; +} + +PUBLIC int +get_gquad_count(short *S, + int i, + int j){ + + int *gg = get_g_islands_sub(S, i, j); + int p,q,counter = 0; + + FOR_EACH_GQUAD(p, q, i, j) + process_gquad_enumeration(gg, p, q, + &gquad_count, + (void *)(&counter), + NULL, + NULL, + NULL); + + gg += i - 1; + free(gg); + return counter; +} + +PUBLIC int +get_gquad_layer_count(short *S, + int i, + int j){ + + int *gg = get_g_islands_sub(S, i, j); + int p,q,counter = 0; + + FOR_EACH_GQUAD(p, q, i, j) + process_gquad_enumeration(gg, p, q, + &gquad_count_layers, + (void *)(&counter), + NULL, + NULL, + NULL); + + gg += i - 1; + free(gg); + return counter; +} + +PUBLIC int parse_gquad(const char *struc, int *L, int l[3]) { + int i, il, start, end, len; + + for (i=0; struc[i] && struc[i]!='+'; i++); + if (struc[i] == '+') { /* start of gquad */ + for (il=0; il<=3; il++) { + start=i; /* pos of first '+' */ + while (struc[++i] == '+'){ + if((il) && (i-start == *L)) + break; + } + end=i; len=end-start; + if (il==0) *L=len; + else if (len!=*L) + nrerror("unequal stack lengths in gquad"); + if (il==3) break; + while (struc[++i] == '.'); /* linker */ + l[il] = i-end; + if (struc[i] != '+') + nrerror("illegal character in gquad linker region"); + } + } + else return 0; + /* printf("gquad at %d %d %d %d %d\n", end, *L, l[0], l[1], l[2]); */ + return end; +} + + + +/* +######################################### +# BEGIN OF PRIVATE FUNCTION DEFINITIONS # +# (internal use only) # +######################################### +*/ + +PRIVATE int gquad_ali_penalty(int i, + int L, + int l[3], + const short **S, + paramT *P){ + + int s, cnt; + int penalty = 0; + int gg_mismatch = 0; + + /* check for compatibility in the alignment */ + for(s = 0; S[s]; s++){ + unsigned int ld = 0; /* !=0 if layer destruction was detected */ + int pen = 0; + + /* check bottom layer */ + if(S[s][i] != 3) ld |= 1U; + if(S[s][i + L + l[0]] != 3) ld |= 2U; + if(S[s][i + 2*L + l[0] + l[1]] != 3) ld |= 4U; + if(S[s][i + 3*L + l[0] + l[1] + l[2]] != 3) ld |= 8U; + /* add 1x penalty for missing bottom layer */ + if(ld) pen += VRNA_GQUAD_MISMATCH_PENALTY; + + /* check top layer */ + ld = 0; + if(S[s][i + L - 1] != 3) ld |= 1U; + if(S[s][i + 2*L + l[0] - 1] != 3) ld |= 2U; + if(S[s][i + 3*L + l[0] + l[1] - 1] != 3) ld |= 4U; + if(S[s][i + 4*L + l[0] + l[1] + l[2] - 1] != 3) ld |= 8U; + /* add 1x penalty for missing top layer */ + if(ld) pen += VRNA_GQUAD_MISMATCH_PENALTY; + + /* check inner layers */ + for(cnt=1;cnt= (2*VRNA_GQUAD_MISMATCH_PENALTY * (L-1))) + gg_mismatch++; + + /* add the penalty to the score */ + penalty += pen; + } + /* if gg_mismatch exceeds maximum allowed, this g-quadruplex is forbidden */ + if(gg_mismatch > VRNA_GQUAD_MISMATCH_NUM_ALI) return INF; + else return penalty; +} + + +PRIVATE void gquad_mfe( int i, + int L, + int *l, + void *data, + void *P, + void *NA, + void *NA2){ + + int cc = ((paramT *)P)->gquad[L][l[0] + l[1] + l[2]]; + if(cc < *((int *)data)) + *((int *)data) = cc; +} + +PRIVATE void gquad_mfe_pos( int i, + int L, + int *l, + void *data, + void *P, + void *Lmfe, + void *lmfe){ + + int cc = ((paramT *)P)->gquad[L][l[0] + l[1] + l[2]]; + if(cc < *((int *)data)){ + *((int *)data) = cc; + *((int *)Lmfe) = L; + *((int *)lmfe) = l[0]; + *(((int *)lmfe) + 1) = l[1]; + *(((int *)lmfe) + 2) = l[2]; + } +} + +PRIVATE +void +gquad_pos_exhaustive( int i, + int L, + int *l, + void *data, + void *P, + void *Lex, + void *lex){ + + int cnt; + int cc = ((paramT *)P)->gquad[L][l[0] + l[1] + l[2]]; + if(cc <= *((int *)data)){ + /* since Lex is an array of L values and lex an + array of l triples we need to find out where + the current gquad position is to be stored... + the below implementation might be slow but we + still use it for now + */ + for(cnt = 0; ((int *)Lex)[cnt] != -1; cnt++); + + *((int *)Lex + cnt) = L; + *((int *)Lex + cnt + 1) = -1; + *(((int *)lex) + (3*cnt) + 0) = l[0]; + *(((int *)lex) + (3*cnt) + 1) = l[1]; + *(((int *)lex) + (3*cnt) + 2) = l[2]; + } +} + +PRIVATE +void +gquad_count(int i, + int L, + int *l, + void *data, + void *NA, + void *NA2, + void *NA3){ + + *((int *)data) += 1; +} + +PRIVATE +void +gquad_count_layers( int i, + int L, + int *l, + void *data, + void *NA, + void *NA2, + void *NA3){ + + *((int *)data) += L; +} + + +PRIVATE void gquad_pf(int i, + int L, + int *l, + void *data, + void *pf, + void *NA, + void *NA2){ + + *((FLT_OR_DBL *)data) += ((pf_paramT *)pf)->expgquad[L][l[0] + l[1] + l[2]]; +} + +PRIVATE void gquad_pf_pos(int i, + int L, + int *l, + void *data, + void *pf, + void *Lmax, + void *lmax){ + + FLT_OR_DBL gq = ((pf_paramT *)pf)->expgquad[L][l[0] + l[1] + l[2]]; + if(gq > *((FLT_OR_DBL *)data)){ + *((FLT_OR_DBL *)data) = gq; + *((int *)Lmax) = L; + *((int *)lmax) = l[0]; + *(((int *)lmax) + 1) = l[1]; + *(((int *)lmax) + 2) = l[2]; + } +} + +PRIVATE void gquad_mfe_ali( int i, + int L, + int *l, + void *data, + void *P, + void *S, + void *n_seq){ + + int en[2], cc; + en[0] = en[1] = INF; + gquad_mfe_ali_en(i, L, l, (void *)(&(en[0])), P, S, n_seq); + if(en[1] != INF){ + cc = en[0] + en[1]; + if(cc < *((int *)data)) *((int *)data) = cc; + } +} + +PRIVATE void gquad_mfe_ali_en(int i, + int L, + int *l, + void *data, + void *P, + void *S, + void *n_seq){ + + int en[2], cc, dd; + en[0] = ((paramT *)P)->gquad[L][l[0] + l[1] + l[2]] * (*(int *)n_seq); + en[1] = gquad_ali_penalty(i, L, l, (const short **)S, (paramT *)P); + if(en[1] != INF){ + cc = en[0] + en[1]; + dd = ((int *)data)[0] + ((int *)data)[1]; + if(cc < dd){ + ((int *)data)[0] = en[0]; + ((int *)data)[1] = en[1]; + } + } +} + +PRIVATE void gquad_interact(int i, + int L, + int *l, + void *data, + void *pf, + void *index, + void *NA2){ + + int x, *idx; + FLT_OR_DBL gq, *pp; + + idx = (int *)index; + pp = (FLT_OR_DBL *)data; + gq = exp_E_gquad(L, l, (pf_paramT *)pf); + + for(x = 0; x < L; x++){ + pp[idx[i + x] - (i + x + 3*L + l[0] + l[1] + l[2])] += gq; + pp[idx[i + x] - (i + x + L + l[0])] += gq; + pp[idx[i + x + L + l[0]] - (i + x + 2*L + l[0] + l[1])] += gq; + pp[idx[i + x + 2*L + l[0] + l[1]] - (i + x + 3*L + l[0] + l[1] + l[2])] += gq; + } + +} + +PRIVATE INLINE int *get_g_islands(short *S){ + return get_g_islands_sub(S, 1, S[0]); +} + +PRIVATE INLINE int *get_g_islands_sub(short *S, int i, int j){ + int x, *gg; + + gg = (int *)space(sizeof(int)*(j-i+2)); + gg -= i - 1; + + if(S[j]==3) gg[j] = 1; + for(x = j - 1; x >= i; x--) + if(S[x] == 3) + gg[x] = gg[x+1]+1; + + return gg; +} + +/** + * We could've also created a macro that loops over all G-quadruplexes + * delimited by i and j. However, for the fun of it we use this function + * that receives a pointer to a callback function which in turn does the + * actual computation for each quadruplex found. + */ +PRIVATE +void +process_gquad_enumeration(int *gg, + int i, + int j, + void (*f)(int, int, int *, + void *, void *, void *, void *), + void *data, + void *P, + void *aux1, + void *aux2){ + + int L, l[3], n, max_linker, maxl0, maxl1; + + n = j - i + 1; + + if((n >= VRNA_GQUAD_MIN_BOX_SIZE) && (n <= VRNA_GQUAD_MAX_BOX_SIZE)) + for(L = MIN2(gg[i], VRNA_GQUAD_MAX_STACK_SIZE); + L >= VRNA_GQUAD_MIN_STACK_SIZE; + L--) + if(gg[j-L+1] >= L){ + max_linker = n-4*L; + if( (max_linker >= 3*VRNA_GQUAD_MIN_LINKER_LENGTH) + && (max_linker <= 3*VRNA_GQUAD_MAX_LINKER_LENGTH)){ + maxl0 = MIN2( VRNA_GQUAD_MAX_LINKER_LENGTH, + max_linker - 2*VRNA_GQUAD_MIN_LINKER_LENGTH + ); + for(l[0] = VRNA_GQUAD_MIN_LINKER_LENGTH; + l[0] <= maxl0; + l[0]++) + if(gg[i+L+l[0]] >= L){ + maxl1 = MIN2( VRNA_GQUAD_MAX_LINKER_LENGTH, + max_linker - l[0] - VRNA_GQUAD_MIN_LINKER_LENGTH + ); + for(l[1] = VRNA_GQUAD_MIN_LINKER_LENGTH; + l[1] <= maxl1; + l[1]++) + if(gg[i + 2*L + l[0] + l[1]] >= L){ + l[2] = max_linker - l[0] - l[1]; + f(i, L, &(l[0]), data, P, aux1, aux2); + } + } + } + } +} + diff --git a/cbits/params.c b/cbits/params.c new file mode 100644 --- /dev/null +++ b/cbits/params.c @@ -0,0 +1,751 @@ +/* + + c Ivo Hofacker + + Vienna RNA package +*/ +#include +#include +#include +#include +#include +#include "energy_par.h" +#include "fold_vars.h" +#include "utils.h" +#include "params.h" +/** +*** \file params.c +***

+*** This file provides functions that return temperature scaled energy parameters and +*** Boltzmann weights packed in datastructures +***

+***/ + +/*@unused@*/ +static char rcsid[] UNUSED = "$Id: params.c,v 1.9 2008/07/04 14:29:14 ivo Exp $"; + +PRIVATE paramT p; +PRIVATE int id=-1; +/* variables for partition function */ +PRIVATE pf_paramT pf; +PRIVATE int pf_id=-1; + +#ifdef _OPENMP +#pragma omp threadprivate(id, pf_id) +#endif + +PUBLIC paramT *scale_parameters(void){ + model_detailsT md; + set_model_details(&md); + return get_scaled_parameters(temperature, md); +} + +PUBLIC paramT *get_scaled_parameters( double temp, + model_detailsT md){ + + unsigned int i,j,k,l; + double tempf; + paramT *params; + + params = (paramT *)space(sizeof(paramT)); + + /* store the model details */ + params->model_details = md; + params->temperature = temp; + tempf = ((params->temperature+K0)/Tmeasure); + + for(i = VRNA_GQUAD_MIN_STACK_SIZE; i <= VRNA_GQUAD_MAX_STACK_SIZE; i++) + for(j = 3*VRNA_GQUAD_MIN_LINKER_LENGTH; j <= 3*VRNA_GQUAD_MAX_LINKER_LENGTH; j++){ + double GQuadAlpha_T = (double)GQuadAlphadH - (double)(GQuadAlphadH - GQuadAlpha37) * tempf; + double GQuadBeta_T = (double)GQuadBetadH - (double)(GQuadBetadH - GQuadBeta37) * tempf; + params->gquad[i][j] = (int)GQuadAlpha_T*(i-1) + (int)(((double)GQuadBeta_T)*log(j - 2)); + } + + for (i=0; i<31; i++) + params->hairpin[i] = hairpindH[i] - (hairpindH[i] - hairpin37[i])*tempf; + for (i=0; i<=MIN2(30,MAXLOOP); i++) { + params->bulge[i] = bulgedH[i] - (bulgedH[i] - bulge37[i]) * tempf; + params->internal_loop[i] = internal_loopdH[i] - (internal_loopdH[i] - internal_loop37[i]) * tempf; + } + params->lxc = lxc37*tempf; + for (; i<=MAXLOOP; i++) { + params->bulge[i] = params->bulge[30]+(int)(params->lxc*log((double)(i)/30.)); + params->internal_loop[i] = params->internal_loop[30]+(int)(params->lxc*log((double)(i)/30.)); + } + + params->ninio[2] = niniodH - (niniodH - ninio37) * tempf; + + params->TripleC = TripleCdH - (TripleCdH - TripleC37) * tempf; + params->MultipleCA = MultipleCAdH - (MultipleCAdH - MultipleCA37) * tempf; + params->MultipleCB = MultipleCBdH - (MultipleCBdH - MultipleCB37) * tempf; + + for (i=0; (i*7)Tetraloop_E[i] = TetraloopdH[i] - (TetraloopdH[i]-Tetraloop37[i])*tempf; + for (i=0; (i*5)Triloop_E[i] = TriloopdH[i] - (TriloopdH[i]-Triloop37[i])*tempf; + for (i=0; (i*9)Hexaloop_E[i] = HexaloopdH[i] - (HexaloopdH[i]-Hexaloop37[i])*tempf; + + params->TerminalAU = TerminalAUdH - (TerminalAUdH - TerminalAU37) * tempf; + + params->DuplexInit = DuplexInitdH - (DuplexInitdH - DuplexInit37) *tempf; + + params->MLbase = ML_BASEdH - (ML_BASEdH - ML_BASE37) * tempf; + + for (i=0; i<=NBPAIRS; i++) + params->MLintern[i] = ML_interndH - (ML_interndH - ML_intern37) * tempf; + + params->MLclosing = ML_closingdH - (ML_closingdH - ML_closing37) * tempf; + + + /* stacks G(T) = H - [H - G(T0)]*T/T0 */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + params->stack[i][j] = stackdH[i][j] - (stackdH[i][j] - stack37[i][j])*tempf; + + /* mismatches */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<5; j++) + for (k=0; k<5; k++) { + int mm; + params->mismatchI[i][j][k] = mismatchIdH[i][j][k] - (mismatchIdH[i][j][k] - mismatchI37[i][j][k])*tempf; + params->mismatchH[i][j][k] = mismatchHdH[i][j][k] - (mismatchHdH[i][j][k] - mismatchH37[i][j][k])*tempf; + params->mismatch1nI[i][j][k] = mismatch1nIdH[i][j][k]-(mismatch1nIdH[i][j][k]-mismatch1nI37[i][j][k])*tempf;/* interior nx1 loops */ + params->mismatch23I[i][j][k] = mismatch23IdH[i][j][k]-(mismatch23IdH[i][j][k]-mismatch23I37[i][j][k])*tempf;/* interior 2x3 loops */ + if(md.dangles){ + mm = mismatchMdH[i][j][k] - (mismatchMdH[i][j][k] - mismatchM37[i][j][k])*tempf; + params->mismatchM[i][j][k] = (mm > 0) ? 0 : mm; + mm = mismatchExtdH[i][j][k] - (mismatchExtdH[i][j][k] - mismatchExt37[i][j][k])*tempf; + params->mismatchExt[i][j][k] = (mm > 0) ? 0 : mm; + } + else{ + params->mismatchM[i][j][k] = params->mismatchExt[i][j][k] = 0; + } + } + + /* dangles */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<5; j++) { + int dd; + dd = dangle5_dH[i][j] - (dangle5_dH[i][j] - dangle5_37[i][j])*tempf; + params->dangle5[i][j] = (dd>0) ? 0 : dd; /* must be <= 0 */ + dd = dangle3_dH[i][j] - (dangle3_dH[i][j] - dangle3_37[i][j])*tempf; + params->dangle3[i][j] = (dd>0) ? 0 : dd; /* must be <= 0 */ + } + /* interior 1x1 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) + params->int11[i][j][k][l] = int11_dH[i][j][k][l] - (int11_dH[i][j][k][l] - int11_37[i][j][k][l])*tempf; + + /* interior 2x1 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m; + for (m=0; m<5; m++) + params->int21[i][j][k][l][m] = int21_dH[i][j][k][l][m] - (int21_dH[i][j][k][l][m] - int21_37[i][j][k][l][m])*tempf; + } + /* interior 2x2 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m,n; + for (m=0; m<5; m++) + for (n=0; n<5; n++) + params->int22[i][j][k][l][m][n] = int22_dH[i][j][k][l][m][n] - (int22_dH[i][j][k][l][m][n]-int22_37[i][j][k][l][m][n])*tempf; + } + + strncpy(params->Tetraloops, Tetraloops, 281); + strncpy(params->Triloops, Triloops, 241); + strncpy(params->Hexaloops, Hexaloops, 361); + + params->id = ++id; + return params; +} + + +/*------------------------------------------------------------------------*/ +#define SCALE 10 +/** +*** dangling ends should never be destabilizing, i.e. expdangle>=1
+*** specific heat needs smooth function (2nd derivative)
+*** we use a*(sin(x+b)+1)^2, with a=2/(3*sqrt(3)), b=Pi/6-sqrt(3)/2, +*** in the interval b0.8660254)?(X):\ + SCALE*0.38490018*(sin((X)/SCALE-0.34242663)+1)*(sin((X)/SCALE-0.34242663)+1)) + +/* #define SMOOTH(X) ((X)<0 ? 0 : (X)) */ + + +PUBLIC pf_paramT *get_scaled_pf_parameters(void){ + model_detailsT md; + set_model_details(&md); + return get_boltzmann_factors(temperature, 1.0, md, pf_scale); +} + +PUBLIC pf_paramT *get_boltzmann_factors(double temp, + double betaScale, + model_detailsT md, + double pf_scale){ + + unsigned int i, j, k, l; + double kT, TT; + double GT; + pf_paramT *pf; + + pf = (pf_paramT *)space(sizeof(pf_paramT)); + pf->model_details = md; + pf->temperature = temp; + pf->alpha = betaScale; + pf->kT = kT = betaScale*(temp+K0)*GASCONST; /* kT in cal/mol */ + pf->pf_scale = pf_scale; + TT = (temp+K0)/(Tmeasure); + + for(i = VRNA_GQUAD_MIN_STACK_SIZE; i <= VRNA_GQUAD_MAX_STACK_SIZE; i++) + for(j = 3*VRNA_GQUAD_MIN_LINKER_LENGTH; j <= 3*VRNA_GQUAD_MAX_LINKER_LENGTH; j++){ + double GQuadAlpha_T = (double)GQuadAlphadH - (double)(GQuadAlphadH - GQuadAlpha37) * TT; + double GQuadBeta_T = (double)GQuadBetadH - (double)(GQuadBetadH - GQuadBeta37) * TT; + GT = ((double)GQuadAlpha_T)*((double)(i-1)) + ((double)GQuadBeta_T)*log(((double)j) - 2.); + pf->expgquad[i][j] = exp( -GT*10./kT); + } + + /* loop energies: hairpins, bulges, interior, mulit-loops */ + for (i=0; i<31; i++){ + GT = hairpindH[i] - (hairpindH[i] - hairpin37[i])*TT; + pf->exphairpin[i] = exp( -GT*10./kT); + } + + for (i=0; i<=MIN2(30, MAXLOOP); i++) { + GT = bulgedH[i]- (bulgedH[i] - bulge37[i])*TT; + pf->expbulge[i] = exp( -GT*10./kT); + GT = internal_loopdH[i] - (internal_loopdH[i] - internal_loop37[i])*TT; + pf->expinternal[i] = exp( -GT*10./kT); + } + /* special case of size 2 interior loops (single mismatch) */ + if (james_rule) pf->expinternal[2] = exp ( -80*10./kT); + + pf->lxc = lxc37*TT; + + GT = DuplexInitdH - (DuplexInitdH - DuplexInit37)*TT; + pf->expDuplexInit = exp( -GT*10./kT); + + for (i=31; i<=MAXLOOP; i++) { + GT = bulge37[30]*TT + (pf->lxc*log( i/30.)); + pf->expbulge[i] = exp( -GT*10./kT); + GT = internal_loop37[30]*TT + (pf->lxc*log( i/30.)); + pf->expinternal[i] = exp( -GT*10./kT); + } + + GT = niniodH - (niniodH - ninio37)*TT; + for (j=0; j<=MAXLOOP; j++) + pf->expninio[2][j]=exp(-MIN2(MAX_NINIO,j*GT)*10./kT); + + for (i=0; (i*7)exptetra[i] = exp( -GT*10./kT); + } + for (i=0; (i*5)exptri[i] = exp( -GT*10./kT); + } + for (i=0; (i*9)exphex[i] = exp( -GT*10./kT); + } + GT = ML_closingdH - (ML_closingdH - ML_closing37)*TT; + pf->expMLclosing = exp( -GT*10./kT); + + for (i=0; i<=NBPAIRS; i++) { + GT = ML_interndH - (ML_interndH - ML_intern37)*TT; + /* if (i>2) GT += TerminalAU; */ + pf->expMLintern[i] = exp( -GT*10./kT); + } + GT = TerminalAUdH - (TerminalAUdH - TerminalAU37)*TT; + pf->expTermAU = exp(-GT*10./kT); + + GT = ML_BASEdH - (ML_BASEdH - ML_BASE37)*TT; + + pf->expMLbase=exp(-10.*GT/kT); + + + /* if dangles==0 just set their energy to 0, + don't let dangle energies become > 0 (at large temps), + but make sure go smoothly to 0 */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=4; j++) { + if (md.dangles) { + GT = dangle5_dH[i][j] - (dangle5_dH[i][j] - dangle5_37[i][j])*TT; + pf->expdangle5[i][j] = exp(SMOOTH(-GT)*10./kT); + GT = dangle3_dH[i][j] - (dangle3_dH[i][j] - dangle3_37[i][j])*TT; + pf->expdangle3[i][j] = exp(SMOOTH(-GT)*10./kT); + } else + pf->expdangle3[i][j] = pf->expdangle5[i][j] = 1; + } + + /* stacking energies */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) { + GT = stackdH[i][j] - (stackdH[i][j] - stack37[i][j])*TT; + pf->expstack[i][j] = exp( -GT*10./kT); + } + + /* mismatch energies */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<5; j++) + for (k=0; k<5; k++) { + GT = mismatchIdH[i][j][k] - ( mismatchIdH[i][j][k] - mismatchI37[i][j][k])*TT; + pf->expmismatchI[i][j][k] = exp(-GT*10.0/kT); + GT = mismatch1nIdH[i][j][k] - (mismatch1nIdH[i][j][k] - mismatch1nI37[i][j][k])*TT; + pf->expmismatch1nI[i][j][k] = exp(-GT*10.0/kT); + GT = mismatchHdH[i][j][k] - (mismatchHdH[i][j][k] - mismatchH37[i][j][k])*TT; + pf->expmismatchH[i][j][k] = exp(-GT*10.0/kT); + if (md.dangles) { + GT = mismatchMdH[i][j][k] - (mismatchMdH[i][j][k] - mismatchM37[i][j][k])*TT; + pf->expmismatchM[i][j][k] = exp(SMOOTH(-GT)*10.0/kT); + GT = mismatchExtdH[i][j][k] - (mismatchExtdH[i][j][k] - mismatchExt37[i][j][k])*TT; + pf->expmismatchExt[i][j][k] = exp(SMOOTH(-GT)*10.0/kT); + } + else{ + pf->expmismatchM[i][j][k] = pf->expmismatchExt[i][j][k] = 1.; + } + GT = mismatch23IdH[i][j][k] - (mismatch23IdH[i][j][k] - mismatch23I37[i][j][k])*TT; + pf->expmismatch23I[i][j][k] = exp(-GT*10.0/kT); + } + + /* interior lops of length 2 */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + GT = int11_dH[i][j][k][l] - + (int11_dH[i][j][k][l] - int11_37[i][j][k][l])*TT; + pf->expint11[i][j][k][l] = exp(-GT*10./kT); + } + /* interior 2x1 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m; + for (m=0; m<5; m++) { + GT = int21_dH[i][j][k][l][m] - + (int21_dH[i][j][k][l][m] - int21_37[i][j][k][l][m])*TT; + pf->expint21[i][j][k][l][m] = exp(-GT*10./kT); + } + } + + /* interior 2x2 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m,n; + for (m=0; m<5; m++) + for (n=0; n<5; n++) { + GT = int22_dH[i][j][k][l][m][n] - + (int22_dH[i][j][k][l][m][n]-int22_37[i][j][k][l][m][n])*TT; + pf->expint22[i][j][k][l][m][n] = exp(-GT*10./kT); + } + } + + strncpy(pf->Tetraloops, Tetraloops, 281); + strncpy(pf->Triloops, Triloops, 241); + strncpy(pf->Hexaloops, Hexaloops, 361); + + return pf; +} + +PUBLIC pf_paramT *get_scaled_alipf_parameters(unsigned int n_seq){ + model_detailsT md; + set_model_details(&md); + return get_boltzmann_factors_ali(n_seq, temperature, 1.0, md, pf_scale); +} + +PUBLIC pf_paramT *get_boltzmann_factors_ali(unsigned int n_seq, + double temperature, + double betaScale, + model_detailsT md, + double pf_scale){ + + /* scale energy parameters and pre-calculate Boltzmann weights */ + unsigned int i, j, k, l; + double kTn, TT; + double GT; + pf_paramT *pf; + + pf = (pf_paramT *)space(sizeof(pf_paramT)); + pf->model_details = md; + pf->alpha = betaScale; + pf->temperature = temperature; + pf->pf_scale = pf_scale; + pf->kT = kTn = ((double)n_seq)*betaScale*(temperature+K0)*GASCONST; /* kT in cal/mol */ + TT = (temperature+K0)/(Tmeasure); + + + /* loop energies: hairpins, bulges, interior, mulit-loops */ + for (i=0; i<31; i++) { + GT = hairpindH[i] - (hairpindH[i] - hairpin37[i])*TT; + pf->exphairpin[i] = exp( -GT*10./kTn); + } + /*add penalty for too short hairpins*/ + for (i=0; i<3; i++) { + GT= 600/*Penalty*/*TT; + pf->exphairpin[i] = exp( -GT*10./kTn); + } + + for (i=0; i<=MIN2(30, MAXLOOP); i++) { + GT = bulgedH[i]- (bulgedH[i] - bulge37[i])*TT; + pf->expbulge[i] = exp( -GT*10./kTn); + GT = internal_loopdH[i] - (internal_loopdH[i] - internal_loop37[i])*TT; + pf->expinternal[i] = exp( -GT*10./kTn); + } + /* special case of size 2 interior loops (single mismatch) */ + if (james_rule) pf->expinternal[2] = exp ( -80*10./kTn); + + pf->lxc = lxc37*TT; + + GT = DuplexInitdH - (DuplexInitdH - DuplexInit37)*TT; + pf->expDuplexInit = exp( -GT*10./kTn); + + for (i=31; i<=MAXLOOP; i++) { + GT = bulge37[30]*TT + (pf->lxc*log( i/30.)); + pf->expbulge[i] = exp( -GT*10./kTn); + GT = internal_loop37[30]*TT + (pf->lxc*log( i/30.)); + pf->expinternal[i] = exp( -GT*10./kTn); + } + + GT = niniodH - (niniodH - ninio37)*TT; + for (j=0; j<=MAXLOOP; j++) + pf->expninio[2][j]=exp(-MIN2(MAX_NINIO,j*GT)*10./kTn); + + for (i=0; (i*7)exptetra[i] = exp( -GT*10./kTn); + } + for (i=0; (i*5)exptri[i] = exp( -GT*10./kTn); + } + for (i=0; (i*9)exphex[i] = exp( -GT*10./kTn); + } + GT = ML_closingdH - (ML_closingdH - ML_closing37)*TT; + pf->expMLclosing = exp( -GT*10./kTn); + + for (i=0; i<=NBPAIRS; i++) { /* includes AU penalty */ + GT = ML_interndH - (ML_interndH - ML_intern37)*TT; + /* if (i>2) GT += TerminalAU; */ + pf->expMLintern[i] = exp( -GT*10./kTn); + } + GT = TerminalAUdH - (TerminalAUdH - TerminalAU37)*TT; + pf->expTermAU = exp(-GT*10./kTn); + + GT = ML_BASEdH - (ML_BASEdH - ML_BASE37)*TT; + pf->expMLbase=exp(-10.*GT/(kTn/n_seq)); + + + /* if dangle_model==0 just set their energy to 0, + don't let dangle energies become > 0 (at large temps), + but make sure go smoothly to 0 */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=4; j++) { + if (md.dangles) { + GT = dangle5_dH[i][j] - (dangle5_dH[i][j] - dangle5_37[i][j])*TT; + pf->expdangle5[i][j] = exp(SMOOTH(-GT)*10./kTn); + GT = dangle3_dH[i][j] - (dangle3_dH[i][j] - dangle3_37[i][j])*TT; + pf->expdangle3[i][j] = exp(SMOOTH(-GT)*10./kTn); + } else + pf->expdangle3[i][j] = pf->expdangle5[i][j] = 1; + } + + /* stacking energies */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) { + GT = stackdH[i][j] - (stackdH[i][j] - stack37[i][j])*TT; + pf->expstack[i][j] = exp( -GT*10./kTn); + } + + /* mismatch energies */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<5; j++) + for (k=0; k<5; k++) { + GT = mismatchIdH[i][j][k] - ( mismatchIdH[i][j][k] - mismatchI37[i][j][k])*TT; + pf->expmismatchI[i][j][k] = exp(-GT*10.0/kTn); + GT = mismatch1nIdH[i][j][k] - (mismatch1nIdH[i][j][k] - mismatch1nI37[i][j][k])*TT; + pf->expmismatch1nI[i][j][k] = exp(-GT*10.0/kTn); + GT = mismatchHdH[i][j][k] - (mismatchHdH[i][j][k] - mismatchH37[i][j][k])*TT; + pf->expmismatchH[i][j][k] = exp(-GT*10.0/kTn); + if (md.dangles) { + GT = mismatchMdH[i][j][k] - (mismatchMdH[i][j][k] - mismatchM37[i][j][k])*TT; + pf->expmismatchM[i][j][k] = exp(SMOOTH(-GT)*10.0/kTn); + GT = mismatchExtdH[i][j][k] - (mismatchExtdH[i][j][k] - mismatchExt37[i][j][k])*TT; + pf->expmismatchExt[i][j][k] = exp(SMOOTH(-GT)*10.0/kTn); + } + else{ + pf->expmismatchM[i][j][k] = pf->expmismatchExt[i][j][k] = 1.; + } + GT = mismatch23IdH[i][j][k] - (mismatch23IdH[i][j][k] - mismatch23I37[i][j][k])*TT; + pf->expmismatch23I[i][j][k] = exp(-GT*10.0/kTn); + } + + + /* interior lops of length 2 */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + GT = int11_dH[i][j][k][l] - + (int11_dH[i][j][k][l] - int11_37[i][j][k][l])*TT; + pf->expint11[i][j][k][l] = exp(-GT*10./kTn); + } + /* interior 2x1 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m; + for (m=0; m<5; m++) { + GT = int21_dH[i][j][k][l][m] - + (int21_dH[i][j][k][l][m] - int21_37[i][j][k][l][m])*TT; + pf->expint21[i][j][k][l][m] = exp(-GT*10./kTn); + } + } + + /* interior 2x2 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m,n; + for (m=0; m<5; m++) + for (n=0; n<5; n++) { + GT = int22_dH[i][j][k][l][m][n] - + (int22_dH[i][j][k][l][m][n]-int22_37[i][j][k][l][m][n])*TT; + pf->expint22[i][j][k][l][m][n] = exp(-GT*10./kTn); + } + } + + strncpy(pf->Tetraloops, Tetraloops, 281); + strncpy(pf->Triloops, Triloops, 241); + strncpy(pf->Hexaloops, Hexaloops, 361); + + return pf; +} + +PUBLIC pf_paramT *get_boltzmann_factor_copy(pf_paramT *par){ + pf_paramT *copy = NULL; + if(par){ + copy = (pf_paramT *) space(sizeof(pf_paramT)); + memcpy(copy, par, sizeof(pf_paramT)); + } + return copy; +} + +PUBLIC paramT *get_parameter_copy(paramT *par){ + paramT *copy = NULL; + if(par){ + copy = (paramT *) space(sizeof(paramT)); + memcpy(copy, par, sizeof(paramT)); + } + return copy; +} + +/*###########################################*/ +/*# deprecated functions below #*/ +/*###########################################*/ + +PUBLIC paramT *copy_parameters(void){ + paramT *copy; + if (p.id != id) scale_parameters(); + copy = (paramT *) space(sizeof(paramT)); + memcpy(copy, &p, sizeof(paramT)); + return copy; +} + +PUBLIC paramT *set_parameters(paramT *dest){ + memcpy(&p, dest, sizeof(paramT)); + return &p; +} + +PUBLIC pf_paramT *copy_pf_param(void){ + pf_paramT *copy; + if (pf.id != pf_id) scale_pf_parameters(); + copy = (pf_paramT *) space(sizeof(pf_paramT)); + memcpy(copy, &pf, sizeof(pf_paramT)); + return copy; +} + +PUBLIC pf_paramT *set_pf_param(paramT *dest){ + memcpy(&pf, dest, sizeof(pf_paramT)); + return &pf; +} + +PUBLIC pf_paramT *scale_pf_parameters(void){ + return get_scaled_pf_parameters(); +#if 0 + /* scale energy parameters and pre-calculate Boltzmann weights */ + unsigned int i, j, k, l; + double kT, TT; + double GT; + + /* scale pf_params() in partfunc.c is only a wrapper, that calls + this functions !! */ + + pf.temperature = temperature; + kT = (pf.temperature+K0)*GASCONST; /* kT in cal/mol */ + TT = (pf.temperature+K0)/(Tmeasure); + + /* loop energies: hairpins, bulges, interior, mulit-loops */ + for (i=0; i<31; i++) { + GT = hairpin37[i]*TT; + pf.exphairpin[i] = exp( -GT*10./kT); + } + for (i=0; i<=MIN2(30, MAXLOOP); i++) { + GT = bulge37[i]*TT; + pf.expbulge[i] = exp( -GT*10./kT); + GT = internal_loop37[i]*TT; + pf.expinternal[i] = exp( -GT*10./kT); + } + /* special case of size 2 interior loops (single mismatch) */ + if (james_rule) pf.expinternal[2] = exp ( -80*10./kT); + + pf.lxc = lxc37*TT; + + GT = DuplexInitdH - (DuplexInitdH - DuplexInit37)*TT; + pf.expDuplexInit = exp( -GT*10./kT); + + for (i=31; i<=MAXLOOP; i++) { + GT = bulge37[30]*TT + (pf.lxc*log( i/30.)); + pf.expbulge[i] = exp( -GT*10./kT); + GT = internal_loop37[30]*TT + (pf.lxc*log( i/30.)); + pf.expinternal[i] = exp( -GT*10./kT); + } + + GT = niniodH - (niniodH - ninio37)*TT; + for (j=0; j<=MAXLOOP; j++) + pf.expninio[2][j]=exp(-MIN2(MAX_NINIO,j*GT)*10./kT); + + for (i=0; (i*7)2) GT += TerminalAU; */ + pf.expMLintern[i] = exp( -GT*10./kT); + } + GT = TerminalAUdH - (TerminalAUdH - TerminalAU37)*TT; + pf.expTermAU = exp(-GT*10./kT); + + GT = ML_BASE37*TT; + pf.expMLbase=exp(-10.*GT/kT); + + + /* if dangle_model==0 just set their energy to 0, + don't let dangle energies become > 0 (at large temps), + but make sure go smoothly to 0 */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=4; j++) { + if (dangles) { + GT = dangle5_dH[i][j] - (dangle5_dH[i][j] - dangle5_37[i][j])*TT; + pf.expdangle5[i][j] = exp(SMOOTH(-GT)*10./kT); + GT = dangle3_dH[i][j] - (dangle3_dH[i][j] - dangle3_37[i][j])*TT; + pf.expdangle3[i][j] = exp(SMOOTH(-GT)*10./kT); + } else + pf.expdangle3[i][j] = pf.expdangle5[i][j] = 1; + if (i>2) /* add TermAU penalty into dangle3 */ + pf.expdangle3[i][j] *= pf.expTermAU; + } + + /* stacking energies */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) { + GT = stackdH[i][j] - (stackdH[i][j] - stack37[i][j])*TT; + pf.expstack[i][j] = exp( -GT*10./kT); + } + + /* mismatch energies */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<5; j++) + for (k=0; k<5; k++) { + GT = mismatchIdH[i][j][k] - ( mismatchIdH[i][j][k] - mismatchI37[i][j][k])*TT; + pf.expmismatchI[i][j][k] = exp(-GT*10./kT); + GT = mismatch1nIdH[i][j][k] - (mismatch1nIdH[i][j][k] - mismatch1nI37[i][j][k])*TT; + pf.expmismatch1nI[i][j][k] = exp(-GT*10./kT); + GT = mismatchHdH[i][j][k] - (mismatchHdH[i][j][k] - mismatchH37[i][j][k])*TT; + pf.expmismatchH[i][j][k] = exp(-GT*10./kT); + GT = mismatch23IdH[i][j][k] - (mismatch23IdH[i][j][k] - mismatch23I37[i][j][k])*TT; + pf.expmismatch23I[i][j][k] = exp(-GT*10./kT); + if (dangles) { + GT = mismatchMdH[i][j][k] - (mismatchMdH[i][j][k] - mismatchM37[i][j][k])*TT; + pf.expmismatchM[i][j][k] = exp(-GT*10./kT); + GT = mismatchExtdH[i][j][k] - ( mismatchExtdH[i][j][k] - mismatchExt37[i][j][k])*TT; + pf.expmismatchExt[i][j][k] = exp(-GT*10./kT); + } + else{ + pf.expmismatchM[i][j][k] = pf.expmismatchExt[i][j][k] = 1.; + } + } + + + /* interior lops of length 2 */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + GT = int11_dH[i][j][k][l] - + (int11_dH[i][j][k][l] - int11_37[i][j][k][l])*TT; + pf.expint11[i][j][k][l] = exp(-GT*10./kT); + } + /* interior 2x1 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m; + for (m=0; m<5; m++) { + GT = int21_dH[i][j][k][l][m] - + (int21_dH[i][j][k][l][m] - int21_37[i][j][k][l][m])*TT; + pf.expint21[i][j][k][l][m] = exp(-GT*10./kT); + } + } + + /* interior 2x2 loops */ + for (i=0; i<=NBPAIRS; i++) + for (j=0; j<=NBPAIRS; j++) + for (k=0; k<5; k++) + for (l=0; l<5; l++) { + int m,n; + for (m=0; m<5; m++) + for (n=0; n<5; n++) { + GT = int22_dH[i][j][k][l][m][n] - + (int22_dH[i][j][k][l][m][n]-int22_37[i][j][k][l][m][n])*TT; + pf.expint22[i][j][k][l][m][n] = exp(-GT*10./kT); + } + } + + strncpy(pf.Tetraloops, Tetraloops, 281); + strncpy(pf.Triloops, Triloops, 241); + strncpy(pf.Hexaloops, Hexaloops, 361); + + pf.id = ++pf_id; + return &pf; +#endif +} diff --git a/cbits/part_func.c b/cbits/part_func.c new file mode 100644 --- /dev/null +++ b/cbits/part_func.c @@ -0,0 +1,1714 @@ +/* + partiton function for RNA secondary structures + + Ivo L Hofacker + Vienna RNA package +*/ +/* + $Log: part_func.c,v $ + Revision 1.29 2008/02/23 10:10:49 ivo + list returned from StackProb was sometimes not terminated correctly + + Revision 1.28 2008/01/08 15:08:10 ivo + circular fold would fail for open chain + + Revision 1.27 2007/12/05 13:04:04 ivo + add various circfold variants from Ronny + + Revision 1.26 2007/09/19 12:41:56 ivo + add computation of centroid() structure for RNAfold -p + + Revision 1.25 2007/04/30 15:12:00 ivo + merge RNAup into package + + Revision 1.24 2007/03/03 17:57:44 ivo + make sure entries in scale[] decrease to 0 + + Revision 1.23 2006/12/01 12:40:23 ivo + undo Ulli's accidental commit + + Revision 1.21 2006/08/04 15:39:06 ivo + new function stackProb returns probability for stacks + p[(i,j)(i+1,j-1)] + + Revision 1.20 2004/08/12 12:14:46 ivo + update + + Revision 1.19 2004/05/14 16:28:05 ivo + fix the bug in make_ptype here too (fixed in 1.27 of fold.c) + + Revision 1.18 2004/02/17 10:46:52 ivo + make sure init_pf_fold is called before scale_parameters + + Revision 1.17 2004/02/09 18:37:59 ivo + new mean_bp_dist() function to compute ensemble diversity + + Revision 1.16 2003/08/04 09:14:09 ivo + finish up stochastic backtracking + + Revision 1.15 2002/03/19 16:51:12 ivo + more on stochastic backtracking (still incomplete) + + Revision 1.14 2002/02/08 17:37:23 ivo + set freed S,S1 pointers to NULL + + Revision 1.13 2001/11/16 17:30:04 ivo + add stochastic backtracking (still incomplete) +*/ +#include +#include +#include +#include +#include +#include /* #defines FLT_MAX ... */ +#include + +#include "utils.h" +#include "energy_par.h" +#include "fold_vars.h" +#include "pair_mat.h" +#include "params.h" +#include "loop_energies.h" +#include "gquad.h" +#include "part_func.h" + +#ifdef _OPENMP +#include +#endif + +#define ISOLATED 256.0 + +/* +################################# +# GLOBAL VARIABLES # +################################# +*/ +PUBLIC int st_back = 0; + +/* +################################# +# PRIVATE VARIABLES # +################################# +*/ +PRIVATE FLT_OR_DBL *q = NULL, *qb=NULL, *qm = NULL, *qm1 = NULL, *qqm = NULL, *qqm1 = NULL, *qq = NULL, *qq1 = NULL; +PRIVATE FLT_OR_DBL *probs=NULL, *prml=NULL, *prm_l=NULL, *prm_l1=NULL, *q1k=NULL, *qln=NULL; +PRIVATE FLT_OR_DBL *scale=NULL; +PRIVATE FLT_OR_DBL *expMLbase=NULL; +PRIVATE FLT_OR_DBL qo=0., qho=0., qio=0., qmo=0., *qm2=NULL; +PRIVATE int *jindx=NULL; +PRIVATE int *my_iindx=NULL; +PRIVATE int init_length = -1; /* length in last call to init_pf_fold() */ +PRIVATE int circular=0; +PRIVATE int do_bppm = 1; /* do backtracking per default */ +PRIVATE int struct_constrained = 0; +PRIVATE char *pstruc=NULL; +PRIVATE char *sequence=NULL; +PRIVATE char *ptype=NULL; /* precomputed array of pair types */ +PRIVATE pf_paramT *pf_params=NULL; /* the precomputed Boltzmann weights */ +PRIVATE short *S=NULL, *S1=NULL; +PRIVATE int with_gquad = 0; + +PRIVATE FLT_OR_DBL *G = NULL, *Gj = NULL, *Gj1 = NULL; + +#ifdef _OPENMP + +#pragma omp threadprivate(q, qb, qm, qm1, qqm, qqm1, qq, qq1, prml, prm_l, prm_l1, q1k, qln,\ + probs, scale, expMLbase, qo, qho, qio, qmo, qm2, jindx, my_iindx, init_length,\ + circular, pstruc, sequence, ptype, pf_params, S, S1, do_bppm, struct_constrained,\ + G, Gj, Gj1, with_gquad) + +#endif + +/* +################################# +# PRIVATE FUNCTION DECLARATIONS # +################################# +*/ +PRIVATE void init_partfunc(int length, pf_paramT *parameters); +PRIVATE void scale_pf_params(unsigned int length, pf_paramT *parameters); +PRIVATE void get_arrays(unsigned int length); +PRIVATE void make_ptypes(const short *S, const char *structure); +PRIVATE void pf_circ(const char *sequence, char *structure); +PRIVATE void pf_linear(const char *sequence, char *structure); +PRIVATE void pf_create_bppm(const char *sequence, char *structure); +PRIVATE void backtrack(int i, int j); +PRIVATE void backtrack_qm(int i, int j); +PRIVATE void backtrack_qm1(int i,int j); +PRIVATE void backtrack_qm2(int u, int n); + +/* +################################# +# BEGIN OF FUNCTION DEFINITIONS # +################################# +*/ + +PRIVATE void init_partfunc(int length, pf_paramT *parameters){ + if (length<1) nrerror("init_pf_fold: length must be greater 0"); + +#ifdef _OPENMP +/* Explicitly turn off dynamic threads */ + omp_set_dynamic(0); + free_pf_arrays(); /* free previous allocation */ +#else + if (init_length>0) free_pf_arrays(); /* free previous allocation */ +#endif + +#ifdef SUN4 + nonstandard_arithmetic(); +#else +#ifdef HP9 + fpsetfastmode(1); +#endif +#endif + make_pair_matrix(); + get_arrays((unsigned) length); + scale_pf_params((unsigned) length, parameters); + + init_length = length; +} + +PRIVATE void get_arrays(unsigned int length){ + unsigned int size; + + if((length +1) >= (unsigned int)sqrt((double)INT_MAX)) + nrerror("get_arrays@part_func.c: sequence length exceeds addressable range"); + + size = sizeof(FLT_OR_DBL) * ((length+1)*(length+2)/2); + + q = (FLT_OR_DBL *) space(size); + qb = (FLT_OR_DBL *) space(size); + qm = (FLT_OR_DBL *) space(size); + qm1 = (st_back || circular) ? (FLT_OR_DBL *) space(size) : NULL; + qm2 = (circular) ? (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)) : NULL; + probs = (do_bppm) ? (FLT_OR_DBL *) space(size) : NULL; + + ptype = (char *) space(sizeof(char)*((length+1)*(length+2)/2)); + q1k = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+1)); + qln = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qq = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qq1 = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qqm = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qqm1 = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + prm_l = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + prm_l1 = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + prml = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + expMLbase = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+1)); + scale = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+1)); + + Gj = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + Gj1 = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + + my_iindx = get_iindx(length); + iindx = get_iindx(length); /* for backward compatibility and Perl wrapper */ + jindx = get_indx(length); +} + +/** +*** Allocate memory for all matrices and other stuff +**/ +PUBLIC void free_pf_arrays(void){ + if(q) free(q); + if(qb) free(qb); + if(qm) free(qm); + if(qm1) free(qm1); + if(qm2) free(qm2); + if(ptype) free(ptype); + if(qq) free(qq); + if(qq1) free(qq1); + if(qqm) free(qqm); + if(qqm1) free(qqm1); + if(q1k) free(q1k); + if(qln) free(qln); + if(probs) free(probs); + if(prm_l) free(prm_l); + if(prm_l1) free(prm_l1); + if(prml) free(prml); + if(expMLbase) free(expMLbase); + if(scale) free(scale); + if(my_iindx) free(my_iindx); + if(iindx) free(iindx); /* for backward compatibility and Perl wrapper */ + if(jindx) free(jindx); + if(S) free(S); + if(S1) free(S1); + if(G) free(G); + if(Gj) free(Gj); + if(Gj1) free(Gj1); + + S = S1 = NULL; + q = pr = probs = qb = qm = qm1 = qm2 = qq = qq1 = qqm = qqm1 = q1k = qln = prm_l = prm_l1 = prml = expMLbase = scale = G = Gj = Gj1 = NULL; + my_iindx = jindx = iindx = NULL; + + ptype = NULL; + +#ifdef SUN4 + standard_arithmetic(); +#else +#ifdef HP9 + fpsetfastmode(0); +#endif +#endif + + init_length = 0; +} + +/*-----------------------------------------------------------------*/ +PUBLIC float pf_fold(const char *sequence, char *structure){ + return pf_fold_par(sequence, structure, NULL, do_backtrack, fold_constrained, 0); +} + +PUBLIC float pf_circ_fold(const char *sequence, char *structure){ + return pf_fold_par(sequence, structure, NULL, do_backtrack, fold_constrained, 1); +} + +PUBLIC float pf_fold_par( const char *sequence, + char *structure, + pf_paramT *parameters, + int calculate_bppm, + int is_constrained, + int is_circular){ + + FLT_OR_DBL Q; + double free_energy; + int n = (int) strlen(sequence); + + circular = is_circular; + do_bppm = calculate_bppm; + struct_constrained = is_constrained; + +#ifdef _OPENMP + init_partfunc(n, parameters); +#else + if(parameters) init_partfunc(n, parameters); + else if (n > init_length) init_partfunc(n, parameters); + else if (fabs(pf_params->temperature - temperature)>1e-6) update_pf_params_par(n, parameters); +#endif + + with_gquad = pf_params->model_details.gquad; + S = encode_sequence(sequence, 0); + S1 = encode_sequence(sequence, 1); + + make_ptypes(S, structure); + + /* do the linear pf fold and fill all matrices */ + pf_linear(sequence, structure); + + if(circular) + pf_circ(sequence, structure); /* do post processing step for circular RNAs */ + + if (backtrack_type=='C') Q = qb[my_iindx[1]-n]; + else if (backtrack_type=='M') Q = qm[my_iindx[1]-n]; + else Q = (circular) ? qo : q[my_iindx[1]-n]; + + /* ensemble free energy in Kcal/mol */ + if (Q<=FLT_MIN) fprintf(stderr, "pf_scale too large\n"); + free_energy = (-log(Q)-n*log(pf_params->pf_scale))*pf_params->kT/1000.0; + /* in case we abort because of floating point errors */ + if (n>1600) fprintf(stderr, "free energy = %8.2f\n", free_energy); + + /* calculate base pairing probability matrix (bppm) */ + if(do_bppm){ + pf_create_bppm(sequence, structure); + /* + * Backward compatibility: + * This block may be removed if deprecated functions + * relying on the global variable "pr" vanish from within the package! + */ + pr = probs; + /* + { + if(pr) free(pr); + pr = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL) * ((n+1)*(n+2)/2)); + memcpy(pr, probs, sizeof(FLT_OR_DBL) * ((n+1)*(n+2)/2)); + } + */ + } + return free_energy; +} + +PRIVATE void pf_linear(const char *sequence, char *structure){ + + int n, i,j,k,l, ij, u,u1,d,ii, type, type_2, tt, minl, maxl; + + int noGUclosure; + FLT_OR_DBL expMLstem = 0.; + + FLT_OR_DBL temp, Qmax=0; + FLT_OR_DBL qbt1, *tmp; + + FLT_OR_DBL expMLclosing = pf_params->expMLclosing; + double max_real; + + max_real = (sizeof(FLT_OR_DBL) == sizeof(float)) ? FLT_MAX : DBL_MAX; + + n = (int) strlen(sequence); + + + noGUclosure = pf_params->model_details.noGUclosure; + + /*array initialization ; qb,qm,q + qb,qm,q (i,j) are stored as ((n+1-i)*(n-i) div 2 + n+1-j */ + + if(with_gquad){ + expMLstem = exp_E_MLstem(0, -1, -1, pf_params); + G = get_gquad_pf_matrix(S, scale, pf_params); + } + + for (d=0; d<=TURN; d++) + for (i=1; i<=n-d; i++) { + j=i+d; + ij = my_iindx[i]-j; + q[ij]=1.0*scale[d+1]; + qb[ij]=qm[ij]=0.0; + } + + for (i=1; i<=n; i++) + qq[i]=qq1[i]=qqm[i]=qqm1[i]=0; + + for (j=TURN+2;j<=n; j++) { + for (i=j-TURN-1; i>=1; i--) { + /* construction of partition function of segment i,j*/ + /*firstly that given i binds j : qb(i,j) */ + u = j-i-1; ij = my_iindx[i]-j; + type = ptype[ij]; + if (type!=0) { + /*hairpin contribution*/ + if (((type==3)||(type==4))&&noGUclosure) qbt1 = 0; + else + qbt1 = exp_E_Hairpin(u, type, S1[i+1], S1[j-1], sequence+i-1, pf_params) * scale[u+2]; + /* interior loops with interior pair k,l */ + for (k=i+1; k<=MIN2(i+MAXLOOP+1,j-TURN-2); k++) { + u1 = k-i-1; + for (l=MAX2(k+TURN+1,j-1-MAXLOOP+u1); l1) || circular) ? S1[i-1] : -1, ((ji; k--) temp += (qm[ii-(k-1)] + expMLbase[k-i])*qqm[k]; + qm[ij] = (temp + qqm[i]); + + /*auxiliary matrix qq for cubic order q calculation below */ + qbt1=0.0; + if (type){ + qbt1 += qb[ij]; + qbt1 *= exp_E_ExtLoop(type, ((i>1) || circular) ? S1[i-1] : -1, ((jQmax) { + Qmax = temp; + if (Qmax>max_real/10.) + fprintf(stderr, "Q close to overflow: %d %d %g\n", i,j,temp); + } + if (temp>=max_real) { + PRIVATE char msg[128]; + sprintf(msg, "overflow in pf_fold while calculating q[%d,%d]\n" + "use larger pf_scale", i,j); + nrerror(msg); + } + } + tmp = qq1; qq1 =qq; qq =tmp; + tmp = qqm1; qqm1=qqm; qqm=tmp; + + if(with_gquad){ /* rotate the auxilary g-quadruplex matrices */ + tmp = Gj1; Gj1=Gj; Gj=tmp; + } + } +} + +/* calculate partition function for circular case */ +/* NOTE: this is the postprocessing step ONLY */ +/* You have to call pf_linear first to calculate */ +/* complete circular case!!! */ +PRIVATE void pf_circ(const char *sequence, char *structure){ + + int u, p, q, k, l; + int noGUclosure; + int n = (int) strlen(sequence); + + FLT_OR_DBL qot; + FLT_OR_DBL expMLclosing = pf_params->expMLclosing; + + noGUclosure = pf_params->model_details.noGUclosure; + qo = qho = qio = qmo = 0.; + + /* construct qm2 matrix from qm1 entries */ + for(k=1; kMAXLOOP) break; + lstart = ln1+p-1+n-MAXLOOP; + if(lstart MAXLOOP) continue; + + type2 = ptype[my_iindx[k]-l]; + if(!type2) continue; + qio += qb[my_iindx[p]-q] * qb[my_iindx[k]-l] * exp_E_IntLoop(ln2, ln1, rtype[type2], type, S1[l+1], S1[k-1], S1[p-1], S1[q+1], pf_params) * scale[ln1+ln2]; + } + } /* end of kl double loop */ + } + } /* end of pq double loop */ + + /* 3. Multiloops */ + for(k=TURN+2; kexpMLclosing; + double max_real; + + FLT_OR_DBL expMLstem = (with_gquad) ? exp_E_MLstem(0, -1, -1, pf_params) : 0; + + max_real = (sizeof(FLT_OR_DBL) == sizeof(float)) ? FLT_MAX : DBL_MAX; + + if((S != NULL) && (S1 != NULL)){ + n = S[0]; + Qmax=0; + + for (k=1; k<=n; k++) { + q1k[k] = q[my_iindx[1] - k]; + qln[k] = q[my_iindx[k] -n]; + } + q1k[0] = 1.0; + qln[n+1] = 1.0; + +/* pr = q; */ /* recycling */ + + + /* 1. exterior pair i,j and initialization of pr array */ + if(circular){ + for (i=1; i<=n; i++) { + for (j=i; j<=MIN2(i+TURN,n); j++) + probs[my_iindx[i]-j] = 0; + for (j=i+TURN+1; j<=n; j++) { + ij = my_iindx[i]-j; + type = ptype[ij]; + if (type&&(qb[ij]>0.)) { + probs[ij] = 1./qo; + int rt = rtype[type]; + + /* 1.1. Exterior Hairpin Contribution */ + int u = i + n - j -1; + /* get the loop sequence */ + char loopseq[10]; + if (u<7){ + strcpy(loopseq , sequence+j-1); + strncat(loopseq, sequence, i); + } + tmp2 = exp_E_Hairpin(u, rt, S1[j+1], S1[i-1], loopseq, pf_params) * scale[u]; + + /* 1.2. Exterior Interior Loop Contribution */ + /* 1.2.1. i,j delimtis the "left" part of the interior loop */ + /* (j,i) is "outer pair" */ + for(k=1; k < i-TURN-1; k++){ + int ln1, lstart; + ln1 = k + n - j - 1; + if(ln1>MAXLOOP) break; + lstart = ln1+i-1-MAXLOOP; + if(lstartMAXLOOP) continue; + tmp2 += qb[my_iindx[k] - l] + * exp_E_IntLoop(ln1, + ln2, + rt, + rtype[type_2], + S1[j+1], + S1[i-1], + S1[k-1], + S1[l+1], + pf_params) + * scale[ln1 + ln2]; + } + } + /* 1.2.2. i,j delimtis the "right" part of the interior loop */ + for(k=j+1; k < n-TURN; k++){ + int ln1, lstart; + ln1 = k - j - 1; + if((ln1 + i - 1)>MAXLOOP) break; + lstart = ln1+i-1+n-MAXLOOP; + if(lstartMAXLOOP) continue; + tmp2 += qb[my_iindx[k] - l] + * exp_E_IntLoop(ln2, + ln1, + rtype[type_2], + rt, + S1[l+1], + S1[k-1], + S1[i-1], + S1[j+1], + pf_params) + * scale[ln1 + ln2]; + } + } + /* 1.3 Exterior multiloop decomposition */ + /* 1.3.1 Middle part */ + if((i>TURN+2) && (j0.)) { + probs[ij] = q1k[i-1]*qln[j+1]/q1k[n]; + probs[ij] *= exp_E_ExtLoop(type, (i>1) ? S1[i-1] : -1, (jTURN+1; l--) { + + /* 2. bonding k,l as substem of 2:loop enclosed by i,j */ + for (k=1; k0.)) { + /* add *scale[u1+u2+2] */ + tmp2 += probs[ij] + * (scale[k-i+j-l] + * exp_E_IntLoop(k - i - 1, + j - l - 1, + type, + type_2, + S1[i + 1], + S1[j - 1], + S1[k - 1], + S1[l + 1], + pf_params)); + } + } + probs[kl] += tmp2; + } + + if(with_gquad){ + /* 2.5. bonding k,l as gquad enclosed by i,j */ + FLT_OR_DBL *expintern = &(pf_params->expinternal[0]); + FLT_OR_DBL qe; + + if(l < n - 3){ + for(k = 2; k <= l - VRNA_GQUAD_MIN_BOX_SIZE; k++){ + kl = my_iindx[k]-l; + if (G[kl]==0.) continue; + tmp2 = 0.; + i = k - 1; + for(j = MIN2(l + MAXLOOP + 1, n); j > l + 3; j--){ + ij = my_iindx[i] - j; + type = ptype[ij]; + if(!type) continue; + qe = (type > 2) ? pf_params->expTermAU : 1.; + tmp2 += probs[ij] * qe * expintern[j-l-1] * pf_params->expmismatchI[type][S1[i+1]][S1[j-1]] * scale[2]; + } + probs[kl] += tmp2 * G[kl]; + } + } + + if (l < n - 1){ + for (k=3; k<=l-VRNA_GQUAD_MIN_BOX_SIZE; k++) { + kl = my_iindx[k]-l; + if (G[kl]==0.) continue; + tmp2 = 0.; + for (i=MAX2(1,k-MAXLOOP-1); i<=k-2; i++){ + u1 = k - i - 1; + for (j=l+2; j<=MIN2(l + MAXLOOP - u1 + 1,n); j++) { + ij = my_iindx[i] - j; + type = ptype[ij]; + if(!type) continue; + qe = (type > 2) ? pf_params->expTermAU : 1.; + tmp2 += probs[ij] * qe * expintern[u1+j-l-1] * pf_params->expmismatchI[type][S1[i+1]][S1[j-1]] * scale[2]; + } + } + probs[kl] += tmp2 * G[kl]; + } + } + + if(l < n){ + for(k = 4; k <= l - VRNA_GQUAD_MIN_BOX_SIZE; k++){ + kl = my_iindx[k]-l; + if (G[kl]==0.) continue; + tmp2 = 0.; + j = l + 1; + for (i=MAX2(1,k-MAXLOOP-1); i < k - 3; i++){ + ij = my_iindx[i] - j; + type = ptype[ij]; + if(!type) continue; + qe = (type > 2) ? pf_params->expTermAU : 1.; + tmp2 += probs[ij] * qe * expintern[k - i - 1] * pf_params->expmismatchI[type][S1[i+1]][S1[j-1]] * scale[2]; + } + probs[kl] += tmp2 * G[kl]; + } + } + } + + /* 3. bonding k,l as substem of multi-loop enclosed by i,j */ + prm_MLb = 0.; + if (ll+1 closes the ML with substem (k,l) */ + for (j=l+2; j<=n; j++) { + tt = ptype[ii-j]; tt = rtype[tt]; + if(tt) + prmt += probs[ii-j] * exp_E_MLstem(tt, S1[j-1], S1[i+1], pf_params) * qm[ll-(j-1)]; + } + kl = my_iindx[k]-l; + tt = ptype[kl]; + prmt *= expMLclosing; + prml[ i] = prmt; + prm_l[i] = prm_l1[i]*expMLbase[1]+prmt1; + + prm_MLb = prm_MLb*expMLbase[1] + prml[i]; + /* same as: prm_MLb = 0; + for (i=1; i<=k-1; i++) prm_MLb += prml[i]*expMLbase[k-i-1]; */ + + prml[i] = prml[ i] + prm_l[i]; + + if(with_gquad){ + if ((!tt) && (G[kl] == 0.)) continue; + } else { + if (qb[kl] == 0.) continue; + } + + temp = prm_MLb; + + for (i=1;i<=k-2; i++) + temp += prml[i]*qm[my_iindx[i+1] - (k-1)]; + + if(with_gquad){ + if(tt) + temp *= exp_E_MLstem(tt, (k>1) ? S1[k-1] : -1, (l1) ? S1[k-1] : -1, (lQmax) { + Qmax = probs[kl]; + if (Qmax>max_real/10.) + fprintf(stderr, "P close to overflow: %d %d %g %g\n", + i, j, probs[kl], qb[kl]); + } + if (probs[kl]>=max_real) { + ov++; + probs[kl]=FLT_MAX; + } + + } /* end for (k=..) */ + tmp = prm_l1; prm_l1=prm_l; prm_l=tmp; + + } /* end for (l=..) */ + + for (i=1; i<=n; i++) + for (j=i+TURN+1; j<=n; j++) { + ij = my_iindx[i]-j; + + if(with_gquad){ + if (qb[ij] > 0.) + probs[ij] *= qb[ij]; + if (G[ij] > 0.){ + probs[ij] += q1k[i-1] * G[ij] * qln[j+1]/q1k[n]; + } + } else { + if (qb[ij] > 0.) + probs[ij] *= qb[ij]; + } + } + + if (structure!=NULL) + bppm_to_structure(structure, probs, n); + if (ov>0) fprintf(stderr, "%d overflows occurred while backtracking;\n" + "you might try a smaller pf_scale than %g\n", + ov, pf_params->pf_scale); + } /* end if((S != NULL) && (S1 != NULL)) */ + else + nrerror("bppm calculations have to be done after calling forward recursion\n"); + return; +} + +PRIVATE void scale_pf_params(unsigned int length, pf_paramT *parameters){ + unsigned int i; + double scaling_factor; + + if(pf_params) free(pf_params); + + if(parameters){ + pf_params = get_boltzmann_factor_copy(parameters); + } else { + model_detailsT md; + set_model_details(&md); + pf_params = get_boltzmann_factors(temperature, 1.0, md, pf_scale); + } + + scaling_factor = pf_params->pf_scale; + + /* scaling factors (to avoid overflows) */ + if (scaling_factor == -1) { /* mean energy for random sequences: 184.3*length cal */ + scaling_factor = exp(-(-185+(pf_params->temperature-37.)*7.27)/pf_params->kT); + if (scaling_factor<1) scaling_factor=1; + pf_params->pf_scale = scaling_factor; + pf_scale = pf_params->pf_scale; /* compatibility with RNAup, may be removed sometime */ + } + scale[0] = 1.; + scale[1] = 1./scaling_factor; + expMLbase[0] = 1; + expMLbase[1] = pf_params->expMLbase/scaling_factor; + for (i=2; i<=length; i++) { + scale[i] = scale[i/2]*scale[i-(i/2)]; + expMLbase[i] = pow(pf_params->expMLbase, (double)i) * scale[i]; + } +} + +/*---------------------------------------------------------------------------*/ + +PUBLIC void update_pf_params(int length){ + update_pf_params_par(length, NULL); +} + +PUBLIC void update_pf_params_par(int length, pf_paramT *parameters){ +#ifdef _OPENMP + make_pair_matrix(); /* is this really necessary? */ + scale_pf_params((unsigned) length, parameters); +#else + if(parameters) init_partfunc(length, parameters); + else if (length>init_length) init_partfunc(length, parameters); /* init not update */ + else { + make_pair_matrix(); + scale_pf_params((unsigned) length, parameters); + } +#endif +} + +/*---------------------------------------------------------------------------*/ + +PUBLIC char bppm_symbol(const float *x){ +/* if( ((x[1]-x[2])*(x[1]-x[2]))<0.1&&x[0]<=0.677) return '|'; */ + if( x[0] > 0.667 ) return '.'; + if( x[1] > 0.667 ) return '('; + if( x[2] > 0.667 ) return ')'; + if( (x[1]+x[2]) > x[0] ) { + if( (x[1]/(x[1]+x[2])) > 0.667) return '{'; + if( (x[2]/(x[1]+x[2])) > 0.667) return '}'; + else return '|'; + } + if( x[0] > (x[1]+x[2]) ) return ','; + return ':'; +} + +PUBLIC void bppm_to_structure(char *structure, FLT_OR_DBL *p, unsigned int length){ + int i, j; + int *index = get_iindx(length); + float P[3]; /* P[][0] unpaired, P[][1] upstream p, P[][2] downstream p */ + + for( j=1; j<=length; j++ ) { + P[0] = 1.0; + P[1] = P[2] = 0.0; + for( i=1; imodel_details.noLP; + + n=S[0]; + for (k=1; kn) continue; + type = pair[S[i]][S[j]]; + while ((i>=1)&&(j<=n)) { + if ((i>1)&&(j qln[i+1]*scale[1]) break; /* i is paired */ + } + if (i>=n) break; /* no more pairs */ + /* now find the pairing partner j */ + r = urn() * (qln[i] - qln[i+1]*scale[1]); + for (qt=0, j=i+1; j<=n; j++) { + int type; + type = ptype[my_iindx[i]-j]; + if (type) { + double qkl; + qkl = qb[my_iindx[i]-j]; + if (j1) ? S1[i-1] : -1, (j r) break; /* j is paired */ + } + } + if (j==n+1) nrerror("backtracking failed in ext loop"); + start = j+1; + backtrack(i,j); + } + + return pstruc; +} +char *pbacktrack_circ(char *seq){ + double r, qt; + int i, j, k, l, n; + FLT_OR_DBL expMLclosing = pf_params->expMLclosing; + + sequence = seq; + n = strlen(sequence); + + if (init_length<1) + nrerror("can't backtrack without pf arrays.\n" + "Call pf_circ_fold() before pbacktrack_circ()"); + pstruc = space((n+1)*sizeof(char)); + + /* initialize pstruct with single bases */ + for (i=0; i r) return pstruc; + + for(i=1; (i < n); i++){ + for(j=i+TURN+1;(j<=n); j++){ + + int type, u; + /* 1. first check, wether we can do a hairpin loop */ + u = n-j + i-1; + if (ur){ backtrack(i,j); return pstruc;} + + /* 2. search for (k,l) with which we can close an interior loop */ + for(k=j+1; (k < n); k++){ + int ln1, lstart; + ln1 = k - j - 1; + if(ln1+i-1>MAXLOOP) break; + + lstart = ln1+i-1+n-MAXLOOP; + if(lstart MAXLOOP) continue; + + type2 = ptype[my_iindx[k]-l]; + if(!type) continue; + type2 = rtype[type2]; + qt += qb[my_iindx[i]-j] * qb[my_iindx[k]-l] * exp_E_IntLoop(ln2, ln1, type2, type, S1[l+1], S1[k-1], S1[i-1], S1[j+1], pf_params) * scale[ln1 + ln2]; + /* found an exterior interior loop? also this time, we can go straight */ + /* forward and backtracking the both enclosed parts and we're done */ + if(qt>r){ backtrack(i,j); backtrack(k,l); return pstruc;} + } + } /* end of kl double loop */ + } + } /* end of ij double loop */ + { + /* as we reach this part, we have to search for our barrier between qm and qm2 */ + qt = 0.; + r = urn()*qmo; + for(k=TURN+2; kr){ backtrack_qm(1,k); backtrack_qm2(k+1,n); return pstruc;} + } + } + /* if we reach the actual end of this function, an error has occured */ + /* cause we HAVE TO find an exterior loop or an open chain!!! */ + nrerror("backtracking failed in exterior loop"); + return pstruc; +} + +PRIVATE void backtrack_qm(int i, int j){ + /* divide multiloop into qm and qm1 */ + double qmt, r; + int k; + while(j>i){ + /* now backtrack [i ... j] in qm[] */ + r = urn() * qm[my_iindx[i] - j]; + qmt = qm1[jindx[j]+i]; k=i; + if(qmt= r) break; + } + if(k>j) nrerror("backtrack failed in qm"); + + backtrack_qm1(k,j); + + if(k= r) break; /* no more pairs */ + j = k-1; + } +} + +PRIVATE void backtrack_qm1(int i,int j){ + /* i is paired to l, i=r) break; + } + if (l>j) nrerror("backtrack failed in qm1"); + backtrack(i,l); +} + +PRIVATE void backtrack_qm2(int k, int n){ + double qom2t, r; + int u; + r= urn()*qm2[k]; + /* we have to search for our barrier u between qm1 and qm1 */ + for (qom2t = 0.,u=k+TURN+1; u r) break; + } + if(u==n-TURN) nrerror("backtrack failed in qm2"); + backtrack_qm1(k,u); + backtrack_qm1(u+1,n); +} + +PRIVATE void backtrack(int i, int j){ + int noGUclosure = pf_params->model_details.noGUclosure; + + do { + double r, qbt1; + int k, l, type, u, u1; + + pstruc[i-1] = '('; pstruc[j-1] = ')'; + + r = urn() * qb[my_iindx[i]-j]; + type = ptype[my_iindx[i]-j]; + u = j-i-1; + /*hairpin contribution*/ + if (((type==3)||(type==4))&&noGUclosure) qbt1 = 0; + else + qbt1 = exp_E_Hairpin(u, type, S1[i+1], S1[j-1], sequence+i-1, pf_params)* + scale[u+2]; /* add scale[u+2] */ + + if (qbt1>=r) return; /* found the hairpin we're done */ + + for (k=i+1; k<=MIN2(i+MAXLOOP+1,j-TURN-2); k++) { + u1 = k-i-1; + for (l=MAX2(k+TURN+1,j-1-MAXLOOP+u1); l r) break; + } + if (qbt1 > r) break; + } + if (l=r) break; + } + if (k>=j) nrerror("backtrack failed, can't find split index "); + + backtrack_qm1(k, j); + + j = k-1; + backtrack_qm(i,j); + } +} + +PUBLIC void assign_plist_from_pr(plist **pl, FLT_OR_DBL *probs, int length, double cut_off){ + int i, j, n, count, *index; + count = 0; + n = 2; + + index = get_iindx(length); + + /* first guess of the size needed for pl */ + *pl = (plist *)space(n*length*sizeof(plist)); + + for (i=1; ii != 0; ptr++){ + if (count == n * length - 1){ + n *= 2; + *pl = (plist *)xrealloc(*pl, n * length * sizeof(plist)); + } + /* check if we've already seen this pair */ + for(k = 0; k < count; k++) + if(((*pl)[k].i == ptr->i) && ((*pl)[k].j == ptr->j)) + break; + (*pl)[k].i = ptr->i; + (*pl)[k].j = ptr->j; + (*pl)[k].type = 0; + if(k == count){ + (*pl)[k].p = ptr->p; + count++; + } else + (*pl)[k].p += ptr->p; + } + } else { + (*pl)[count].i = i; + (*pl)[count].j = j; + (*pl)[count].p = probs[index[i] - j]; + (*pl)[count++].type = 0; + } + } + } + /* mark the end of pl */ + (*pl)[count].i = 0; + (*pl)[count].j = 0; + (*pl)[count++].p = 0.; + /* shrink memory to actual size needed */ + *pl = (plist *)xrealloc(*pl, count * sizeof(plist)); + free(index); +} + +/* this doesn't work if free_pf_arrays() is called before */ +PUBLIC char *get_centroid_struct_gquad_pr( int length, + double *dist){ + + /* compute the centroid structure of the ensemble, i.e. the strutcure + with the minimal average distance to all other structures + = \sum_{(i,j) \in S} (1-p_{ij}) + \sum_{(i,j) \notin S} p_{ij} + Thus, the centroid is simply the structure containing all pairs with + p_ij>0.5 */ + int i,j, k; + double p; + char *centroid; + int *my_iindx = get_iindx(length); + + if (probs == NULL) + nrerror("get_centroid_struct_pr: probs==NULL!"); + + *dist = 0.; + centroid = (char *) space((length+1)*sizeof(char)); + for (i=0; i0.5) { + /* check for presence of gquadruplex */ + if((S[i] == 3) && (S[j] == 3)){ + int L, l[3]; + get_gquad_pattern_pf(S, i, j, pf_params, &L, l); + for(k=0;k = \sum_{(i,j) \in S} (1-p_{ij}) + \sum_{(i,j) \notin S} p_{ij} + Thus, the centroid is simply the structure containing all pairs with + p_ij>0.5 */ + int i; + char *centroid; + + if (pl==NULL) + nrerror("get_centroid_struct: pl==NULL!"); + + *dist = 0.; + centroid = (char *) space((length+1)*sizeof(char)); + for (i=0; i0; i++){ + if ((pl[i].p)>0.5) { + centroid[pl[i].i-1] = '('; + centroid[pl[i].j-1] = ')'; + *dist += (1-pl[i].p); + } else + *dist += pl[i].p; + } + centroid[length] = '\0'; + return centroid; +} + +/* this function is a threadsafe replacement for centroid() */ +PUBLIC char *get_centroid_struct_pr(int length, double *dist, FLT_OR_DBL *probs){ + /* compute the centroid structure of the ensemble, i.e. the strutcure + with the minimal average distance to all other structures + = \sum_{(i,j) \in S} (1-p_{ij}) + \sum_{(i,j) \notin S} p_{ij} + Thus, the centroid is simply the structure containing all pairs with + p_ij>0.5 */ + int i,j; + double p; + char *centroid; + int *index = get_iindx(length); + + if (probs == NULL) + nrerror("get_centroid_struct_pr: probs==NULL!"); + + *dist = 0.; + centroid = (char *) space((length+1)*sizeof(char)); + for (i=0; i0.5) { + centroid[i-1] = '('; + centroid[j-1] = ')'; + *dist += (1-p); + } else + *dist += p; + } + free(index); + centroid[length] = '\0'; + return centroid; +} + +PUBLIC plist *stackProb(double cutoff){ + plist *pl; + int i,j,plsize=256; + int num = 0; + + if (probs==NULL) + nrerror("probs==NULL. You need to call pf_fold() before stackProb()"); + + int length = S[0]; + int *index = get_iindx(length); + + pl = (plist *) space(plsize*sizeof(plist)); + + for (i=1; icutoff) { + pl[num].i = i; + pl[num].j = j; + pl[num++].p = p; + if (num>=plsize) { + plsize *= 2; + pl = xrealloc(pl, plsize*sizeof(plist)); + } + } + } + pl[num].i=0; + free(index); + return pl; +} + +/*-------------------------------------------------------------------------*/ +/* make arrays used for pf_fold available to other routines */ +PUBLIC int get_pf_arrays( short **S_p, + short **S1_p, + char **ptype_p, + FLT_OR_DBL **qb_p, + FLT_OR_DBL **qm_p, + FLT_OR_DBL **q1k_p, + FLT_OR_DBL **qln_p){ + + if(qb == NULL) return(0); /* check if pf_fold() has been called */ + *S_p = S; *S1_p = S1; *ptype_p = ptype; + *qb_p = qb; *qm_p = qm; + *q1k_p = q1k; *qln_p = qln; + return(1); /* success */ +} + +/* get the free energy of a subsequence from the q[] array */ +PUBLIC double get_subseq_F(int i, int j){ + if (!q) + nrerror("call pf_fold() to fill q[] array before calling get_subseq_F()"); + return ((-log(q[my_iindx[i]-j])-(j-i+1)*log(pf_params->pf_scale))*pf_params->kT/1000.0); +} + + +PUBLIC double mean_bp_distance(int length){ + return mean_bp_distance_pr(length, probs); +} + +PUBLIC double mean_bp_distance_pr(int length, FLT_OR_DBL *p){ + /* compute the mean base pair distance in the thermodynamic ensemble */ + /* = \sum_{a,b} p_a p_b d(S_a,S_b) + this can be computed from the pair probs p_ij as + = \sum_{ij} p_{ij}(1-p_{ij}) */ + int i,j; + double d=0; + int *index = get_iindx((unsigned int) length); + + if (p==NULL) + nrerror("p==NULL. You need to supply a valid probability matrix for mean_bp_distance_pr()"); + + for (i=1; i<=length; i++) + for (j=i+TURN+1; j<=length; j++) + d += p[index[i]-j] * (1-p[index[i]-j]); + + free(index); + return 2*d; +} + +PUBLIC FLT_OR_DBL *export_bppm(void){ + return probs; +} + +/*###########################################*/ +/*# deprecated functions below #*/ +/*###########################################*/ + +/* this function is deprecated since it is not threadsafe */ +PUBLIC char *centroid(int length, double *dist) { + /* compute the centroid structure of the ensemble, i.e. the strutcure + with the minimal average distance to all other structures + = \sum_{(i,j) \in S} (1-p_{ij}) + \sum_{(i,j) \notin S} p_{ij} + Thus, the centroid is simply the structure containing all pairs with + p_ij>0.5 */ + int i,j; + double p; + char *centroid; + + if (pr==NULL) + nrerror("pr==NULL. You need to call pf_fold() before centroid()"); + + *dist = 0.; + centroid = (char *) space((length+1)*sizeof(char)); + for (i=0; i0.5) { + centroid[i-1] = '('; + centroid[j-1] = ')'; + *dist += (1-p); + } else + *dist += p; + } + return centroid; +} + + +/* This function is deprecated since it uses the global array pr for calculations */ +PUBLIC double mean_bp_dist(int length) { + /* compute the mean base pair distance in the thermodynamic ensemble */ + /* = \sum_{a,b} p_a p_b d(S_a,S_b) + this can be computed from the pair probs p_ij as + = \sum_{ij} p_{ij}(1-p_{ij}) */ + int i,j; + double d=0; + + if (pr==NULL) + nrerror("pr==NULL. You need to call pf_fold() before mean_bp_dist()"); + + for (i=1; i<=length; i++) + for (j=i+TURN+1; j<=length; j++) + d += pr[my_iindx[i]-j] * (1-pr[my_iindx[i]-j]); + return 2*d; +} + +/*----------------------------------------------------------------------*/ +PUBLIC double expHairpinEnergy(int u, int type, short si1, short sj1, + const char *string) { +/* compute Boltzmann weight of a hairpin loop, multiply by scale[u+2] */ + double q, kT; + kT = pf_params->kT; /* kT in cal/mol */ + if(u <= 30) + q = pf_params->exphairpin[u]; + else + q = pf_params->exphairpin[30] * exp( -(pf_params->lxc*log( u/30.))*10./kT); + if ((tetra_loop)&&(u==4)) { + char tl[7]={0}, *ts; + strncpy(tl, string, 6); + if ((ts=strstr(pf_params->Tetraloops, tl))) + return (pf_params->exptetra[(ts-pf_params->Tetraloops)/7]); + } + if ((tetra_loop)&&(u==6)) { + char tl[9]={0}, *ts; + strncpy(tl, string, 6); + if ((ts=strstr(pf_params->Hexaloops, tl))) + return (pf_params->exphex[(ts-pf_params->Hexaloops)/9]); + } + if (u==3) { + char tl[6]={0}, *ts; + strncpy(tl, string, 5); + if ((ts=strstr(pf_params->Triloops, tl))) + return (pf_params->exptri[(ts-pf_params->Triloops)/6]); + if (type>2) + q *= pf_params->expTermAU; + } + else /* no mismatches for tri-loops */ + q *= pf_params->expmismatchH[type][si1][sj1]; + + return q; +} +PUBLIC double expLoopEnergy(int u1, int u2, int type, int type2, + short si1, short sj1, short sp1, short sq1) { +/* compute Boltzmann weight of interior loop, + multiply by scale[u1+u2+2] for scaling */ + double z=0; + int no_close = 0; + + if ((no_closingGU) && ((type2==3)||(type2==4)||(type==2)||(type==4))) + no_close = 1; + + if ((u1==0) && (u2==0)) /* stack */ + z = pf_params->expstack[type][type2]; + else if (no_close==0) { + if ((u1==0)||(u2==0)) { /* bulge */ + int u; + u = (u1==0)?u2:u1; + z = pf_params->expbulge[u]; + if (u2+u1==1) z *= pf_params->expstack[type][type2]; + else { + if (type>2) z *= pf_params->expTermAU; + if (type2>2) z *= pf_params->expTermAU; + } + } + else { /* interior loop */ + if (u1+u2==2) /* size 2 is special */ + z = pf_params->expint11[type][type2][si1][sj1]; + else if ((u1==1) && (u2==2)) + z = pf_params->expint21[type][type2][si1][sq1][sj1]; + else if ((u1==2) && (u2==1)) + z = pf_params->expint21[type2][type][sq1][si1][sp1]; + else if ((u1==2) && (u2==2)) + z = pf_params->expint22[type][type2][si1][sp1][sq1][sj1]; + else if (((u1==2)&&(u2==3))||((u1==3)&&(u2==2))){ /*2-3 is special*/ + z = pf_params->expinternal[5]* + pf_params->expmismatch23I[type][si1][sj1]* + pf_params->expmismatch23I[type2][sq1][sp1]; + z *= pf_params->expninio[2][1]; + } + else if ((u1==1)||(u2==1)) { /*1-n is special*/ + z = pf_params->expinternal[u1+u2]* + pf_params->expmismatch1nI[type][si1][sj1]* + pf_params->expmismatch1nI[type2][sq1][sp1]; + z *= pf_params->expninio[2][abs(u1-u2)]; + } + else { + z = pf_params->expinternal[u1+u2]* + pf_params->expmismatchI[type][si1][sj1]* + pf_params->expmismatchI[type2][sq1][sp1]; + z *= pf_params->expninio[2][abs(u1-u2)]; + } + } + } + return z; +} + +PUBLIC void init_pf_circ_fold(int length){ +/* DO NOTHING */ +} + +PUBLIC void init_pf_fold(int length){ +/* DO NOTHING */ +} + + diff --git a/cbits/part_func_co.c b/cbits/part_func_co.c new file mode 100644 --- /dev/null +++ b/cbits/part_func_co.c @@ -0,0 +1,1046 @@ +/* Last changed Time-stamp: <2007-05-09 16:11:21 ivo> */ +/* + partiton function for RNA secondary structures + + Ivo L Hofacker + Stephan Bernhart + Vienna RNA package +*/ +/* + $Log: part_func_co.c,v $ + Revision 1.10 2007/05/10 17:27:01 ivo + make sure the relative error eps is positive in newton iteration + + Revision 1.9 2006/05/10 15:12:11 ivo + some compiler choked on double semicolon after declaration + + Revision 1.8 2006/04/05 12:52:31 ivo + Fix performance bug (O(n^4) loop) + + Revision 1.7 2006/01/19 11:30:04 ivo + compute_probabilities should only look at one dimer at a time + + Revision 1.6 2006/01/18 12:55:40 ivo + major cleanup of berni code + fix bugs related to confusing which free energy is returned by co_pf_fold() + + Revision 1.5 2006/01/16 11:32:25 ivo + small bug in multiloop pair probs + + Revision 1.4 2006/01/05 18:13:40 ivo + update + + Revision 1.3 2006/01/04 15:14:29 ivo + fix bug in concentration calculations + + Revision 1.2 2004/12/23 12:14:41 berni + *** empty log message *** + + Revision 1.1 2004/12/22 10:46:17 berni + + Partition function Cofolding 0.9, Computation of concentrations. + + Revision 1.16 2003/08/04 09:14:09 ivo + finish up stochastic backtracking + + Revision 1.15 2002/03/19 16:51:12 ivo + more on stochastic backtracking (still incomplete) + + Revision 1.13 2001/11/16 17:30:04 ivo + add stochastic backtracking (still incomplete) +*/ + +#include +#include +#include +#include +#include +#include /* #defines FLT_MAX ... */ +#include + +#include "utils.h" +#include "energy_par.h" +#include "fold_vars.h" +#include "pair_mat.h" +#include "PS_dot.h" +#include "params.h" +#include "loop_energies.h" +#include "part_func.h" +#include "part_func_co.h" + +#ifdef _OPENMP +#include +#endif + + +/*@unused@*/ +PRIVATE char rcsid[] UNUSED = "$Id: part_func_co.c,v 1.10 2007/05/10 17:27:01 ivo Exp $"; + +#define ISOLATED 256.0 +#undef TURN +#define TURN 0 +#define SAME_STRAND(I,J) (((I)>=cut_point)||((J)=cut_point2)||(((I)>=cut_point)&&((J)0) free_co_pf_arrays(); /* free previous allocation */ +#endif + +#ifdef SUN4 + nonstandard_arithmetic(); +#else +#ifdef HP9 + fpsetfastmode(1); +#endif +#endif + make_pair_matrix(); + get_arrays((unsigned) length); + scale_pf_params((unsigned) length, parameters); + init_length = length; +} + +PRIVATE void get_arrays(unsigned int length){ + unsigned int size; + + if((length +1) >= (unsigned int)sqrt((double)INT_MAX)) + nrerror("get_arrays@part_func_co.c: sequence length exceeds addressable range"); + + size = sizeof(FLT_OR_DBL) * ((length+1)*(length+2)/2); + q = (FLT_OR_DBL *) space(size); + qb = (FLT_OR_DBL *) space(size); + qm = (FLT_OR_DBL *) space(size); + probs = (FLT_OR_DBL *) space(size); + qm1 = (FLT_OR_DBL *) space(size); + q1k = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+1)); + qln = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qq = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qq1 = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qqm = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + qqm1 = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + prm_l = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + prm_l1 = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + prml = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+2)); + expMLbase = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+1)); + scale = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL)*(length+1)); + ptype = (char *) space(sizeof(char)*((length+1)*(length+2)/2)); + my_iindx = get_iindx(length); + iindx = get_iindx(length); /* for backward compatibility and Perl wrapper */ + jindx = get_indx(length); +} + +PUBLIC void free_co_pf_arrays(void){ + if(q) free(q); + if(qb) free(qb); + if(qm) free(qm); + if(qm1) free(qm1); + if(ptype) free(ptype); + if(qq) free(qq); + if(qq1) free(qq1); + if(qqm) free(qqm); + if(qqm1) free(qqm1); + if(q1k) free(q1k); + if(qln) free(qln); + if(prm_l) free(prm_l); + if(prm_l1) free(prm_l1); + if(prml) free(prml); + if(probs) free(probs); + if(expMLbase) free(expMLbase); + if(scale) free(scale); + if(my_iindx) free(my_iindx); + if(iindx) free(iindx); /* for backward compatibility and Perl wrapper */ + if(jindx) free(jindx); + if(S) free(S); + if(S1) free(S1); + + init_length=0; + q = qb = qm = qm1 = qq = qq1 = qqm = qqm1 = q1k = qln = prm_l = prm_l1 = prml = expMLbase = scale = probs = NULL; + ptype = NULL; + S = S1 = NULL; + my_iindx = jindx = iindx = NULL; + +#ifdef SUN4 + standard_arithmetic(); +#else +#ifdef HP9 + fpsetfastmode(0); +#endif +#endif +} + +/*-----------------------------------------------------------------*/ +PUBLIC cofoldF co_pf_fold(char *sequence, char *structure){ + return co_pf_fold_par(sequence, structure, NULL, do_backtrack, fold_constrained); +} + +PUBLIC cofoldF co_pf_fold_par(char *sequence, + char *structure, + pf_paramT *parameters, + int calculate_bppm, + int is_constrained){ + + int n; + FLT_OR_DBL Q; + cofoldF X; + double free_energy; + + n = (int) strlen(sequence); + do_bppm = calculate_bppm; + struct_constrained = is_constrained; + +#ifdef _OPENMP + /* always init everything since all global static variables are uninitialized when entering a thread */ + init_partfunc_co(n, parameters); +#else + if(parameters) init_partfunc_co(n, parameters); + else if (n > init_length) init_partfunc_co(n, parameters); + else if (fabs(pf_params->temperature - temperature)>1e-6) update_co_pf_params_par(n, parameters); +#endif + + /* printf("mirnatog=%d\n",mirnatog); */ + + if(S) free(S); + S = encode_sequence(sequence, 0); + if(S1) free(S1); + S1 = encode_sequence(sequence, 1); + + make_ptypes(S, structure); + + pf_co(sequence); + + if (backtrack_type=='C') Q = qb[my_iindx[1]-n]; + else if (backtrack_type=='M') Q = qm[my_iindx[1]-n]; + else Q = q[my_iindx[1]-n]; + /* ensemble free energy in Kcal/mol */ + if (Q<=FLT_MIN) fprintf(stderr, "pf_scale too large\n"); + free_energy = (-log(Q)-n*log(pf_params->pf_scale))*pf_params->kT/1000.0; + /* in case we abort because of floating point errors */ + if (n>1600) fprintf(stderr, "free energy = %8.2f\n", free_energy); + /*probability of molecules being bound together*/ + + + /*Computation of "real" Partition function*/ + /*Need that for concentrations*/ + if (cut_point>0){ + double kT, pbound, QAB, QToT, Qzero; + + kT = pf_params->kT/1000.0; + Qzero=q[my_iindx[1]-n]; + QAB=(q[my_iindx[1]-n]-q[my_iindx[1]-(cut_point-1)]*q[my_iindx[cut_point]-n])*pf_params->expDuplexInit; + /*correction for symmetry*/ + if((n-(cut_point-1)*2)==0) { + if ((strncmp(sequence, sequence+cut_point-1, cut_point-1))==0) { + QAB/=2; + }} + + QToT=q[my_iindx[1]-(cut_point-1)]*q[my_iindx[cut_point]-n]+QAB; + pbound=1-(q[my_iindx[1]-(cut_point-1)]*q[my_iindx[cut_point]-n]/QToT); + X.FAB = -kT*(log(QToT)+n*log(pf_params->pf_scale)); + X.F0AB = -kT*(log(Qzero)+n*log(pf_params->pf_scale)); + X.FcAB = (QAB>1e-17) ? -kT*(log(QAB)+n*log(pf_params->pf_scale)) : 999; + X.FA = -kT*(log(q[my_iindx[1]-(cut_point-1)]) + (cut_point-1)*log(pf_params->pf_scale)); + X.FB = -kT*(log(q[my_iindx[cut_point]-n]) + (n-cut_point+1)*log(pf_params->pf_scale)); + + /* printf("QAB=%.9f\tQtot=%.9f\n",QAB/scale[n],QToT/scale[n]);*/ + } + else { + X.FA = X.FB = X.FAB = X.F0AB = free_energy; + X.FcAB = 0; + } + + /* backtracking to construct binding probabilities of pairs*/ + if(do_bppm){ + pf_co_bppm(sequence, structure); + /* + * Backward compatibility: + * This block may be removed if deprecated functions + * relying on the global variable "pr" vanish from within the package! + */ + pr = probs; + /* + { + if(pr) free(pr); + pr = (FLT_OR_DBL *) space(sizeof(FLT_OR_DBL) * ((n+1)*(n+2)/2)); + memcpy(pr, probs, sizeof(FLT_OR_DBL) * ((n+1)*(n+2)/2)); + } + */ + } + return X; +} + +/* forward recursion of pf cofolding */ +PRIVATE void pf_co(const char *sequence){ + int n, i,j,k,l, ij, u,u1,ii, type, type_2, tt; + FLT_OR_DBL temp, Qmax=0; + FLT_OR_DBL qbt1, *tmp; + FLT_OR_DBL expMLclosing; + double max_real; + int noGUclosure = pf_params->model_details.noGUclosure; + + max_real = (sizeof(FLT_OR_DBL) == sizeof(float)) ? FLT_MAX : DBL_MAX; + n = (int) strlen(sequence); + + expMLclosing = pf_params->expMLclosing; + + + /*array initialization ; qb,qm,q + qb,qm,q (i,j) are stored as ((n+1-i)*(n-i) div 2 + n+1-j */ + + /* for (d=0; d<=TURN; d++) */ + for (i=1; i<=n/*-d*/; i++) { + ij = my_iindx[i]-i; + q[ij]=scale[1]; + qb[ij]=qm[ij]=0.0; + } + + for (i=0; i<=n; i++) + qq[i]=qq1[i]=qqm[i]=qqm1[i]=prm_l[i]=prm_l1[i]=prml[i]=0; + + for (j=TURN+2;j<=n; j++) { + for (i=j-TURN-1; i>=1; i--) { + /* construction of partition function of segment i,j*/ + /*firstly that given i bound to j : qb(i,j) */ + u = j-i-1; ij = my_iindx[i]-j; + type = ptype[ij]; + qbt1=0; + if (type!=0) { + /*hairpin contribution*/ + if SAME_STRAND(i,j){ + if (((type==3)||(type==4))&&noGUclosure) qbt1 = 0; + else + qbt1 = exp_E_Hairpin(u, type, S1[i+1], S1[j-1], sequence+i-1, pf_params)*scale[u+2]; + + } + + /* interior loops with interior pair k,l */ + for (k=i+1; k<=MIN2(i+MAXLOOP+1,j-TURN-2); k++) { + u1 = k-i-1; + for (l=MAX2(k+TURN+1,j-1-MAXLOOP+u1); lcut_point) temp*=scale[1]; + if (i1) ? S1[i-1] : -1, (j1)&&(SAME_STRAND(i-1,i))) ? S1[i-1] : -1, ((jQmax) { + Qmax = temp; + if (Qmax>max_real/10.) + fprintf(stderr, "Q close to overflow: %d %d %g\n", i,j,temp); + } + if (temp>=max_real) { + PRIVATE char msg[128]; + snprintf(msg, 127, "overflow in co_pf_fold while calculating q[%d,%d]\n" + "use larger pf_scale", i,j); + nrerror(msg); + } + } + tmp = qq1; qq1 =qq; qq =tmp; + tmp = qqm1; qqm1=qqm; qqm=tmp; + } +} + +/* backward recursion of pf cofolding */ +PRIVATE void pf_co_bppm(const char *sequence, char *structure){ + int n, i,j,k,l, ij, kl, ii, ll, type, type_2, tt, ov=0; + FLT_OR_DBL temp, Qmax=0, prm_MLb; + FLT_OR_DBL prmt,prmt1; + FLT_OR_DBL *tmp; + FLT_OR_DBL expMLclosing; + double max_real; + + max_real = (sizeof(FLT_OR_DBL) == sizeof(float)) ? FLT_MAX : DBL_MAX; + n = (int) strlen(sequence); + + expMLclosing = pf_params->expMLclosing; + + /* backtracking to construct binding probabilities of pairs*/ + if ((S != NULL) && (S1 != NULL)) { + FLT_OR_DBL *Qlout, *Qrout; + Qmax=0; + Qrout=(FLT_OR_DBL *)space(sizeof(FLT_OR_DBL) * (n+2)); + Qlout=(FLT_OR_DBL *)space(sizeof(FLT_OR_DBL) * (cut_point+2)); + + for (k=1; k<=n; k++) { + q1k[k] = q[my_iindx[1] - k]; + qln[k] = q[my_iindx[k] -n]; + } + q1k[0] = 1.0; + qln[n+1] = 1.0; + + /* pr = q; / * recycling */ + + /* 1. exterior pair i,j and initialization of pr array */ + for (i=1; i<=n; i++) { + for (j=i; j<=MIN2(i+TURN,n); j++) probs[my_iindx[i]-j] = 0; + for (j=i+TURN+1; j<=n; j++) { + ij = my_iindx[i]-j; + type = ptype[ij]; + if (type&&(qb[ij]>0.)) { + probs[ij] = q1k[i-1]*qln[j+1]/q1k[n]; + probs[ij] *= exp_E_ExtLoop(type, ((i>1)&&(SAME_STRAND(i-1,i))) ? S1[i-1] : -1, ((jTURN+1; l--) { + + /* 2. bonding k,l as substem of 2:loop enclosed by i,j */ + for (k=1; k0)) { + probs[kl] += probs[ij]*exp_E_IntLoop(k-i-1, j-l-1, type, type_2, + S1[i+1], S1[j-1], S1[k-1], S1[l+1], pf_params)*scale[k-i+j-l]; + } + } + } + } + /* 3. bonding k,l as substem of multi-loop enclosed by i,j */ + prm_MLb = 0.; + if ((l1)&&SAME_STRAND(k-1,k)) ? S1[k-1] : -1, + ((lQmax) { + Qmax = probs[kl]; + if (Qmax>max_real/10.) + fprintf(stderr, "P close to overflow: %d %d %g %g\n", + i, j, probs[kl], qb[kl]); + } + if (probs[kl]>=max_real) { + ov++; + probs[kl]=FLT_MAX; + } + + } /* end for (k=..) multloop*/ + else /* set prm_l to 0 to get prm_l1 to be 0 */ + for (i=0; i<=n; i++) prm_l[i]=0; + + tmp = prm_l1; prm_l1=prm_l; prm_l=tmp; + /*computation of .(..(...)..&..). type features?*/ + if (cut_point<=0) continue; /* no .(..(...)..&..). type features*/ + if ((l==n)||(l<=2)) continue; /* no .(..(...)..&..). type features*/ + /*new version with O(n^3)??*/ + if (l>cut_point) { + if (ll; t--) { + for (k=1; k=cut_point; k--) { + if (qb[my_iindx[k]-l]) { + kl=my_iindx[k]-l; + type=ptype[kl]; + temp = Qrout[l]; + temp *= exp_E_ExtLoop(type, (k>cut_point) ? S1[k-1] : -1, (l < n) ? S1[l+1] : -1, pf_params); + if (k>cut_point) temp*=q[my_iindx[cut_point]-(k-1)]; + probs[kl]+=temp; + } + } + } + else if (l==cut_point ) { + int t, sk,s; + for (t=2; t1) ? S1[k-1] : -1, (l<(cut_point-1)) ? S1[l+1] : -1, pf_params); + if (l+10) fprintf(stderr, "%d overflows occurred while backtracking;\n" + "you might try a smaller pf_scale than %g\n", + ov, pf_params->pf_scale); +} + + +PRIVATE void scale_pf_params(unsigned int length, pf_paramT *parameters){ + unsigned int i; + double kT, scaling_factor; + + if(pf_params) free(pf_params); + + if(parameters){ + pf_params = get_boltzmann_factor_copy(parameters); + } else { + model_detailsT md; + set_model_details(&md); + pf_params = get_boltzmann_factors(temperature, alpha, md, pf_scale); + } + + scaling_factor = pf_params->pf_scale; + kT = pf_params->kT; /* kT in cal/mol */ + + /* scaling factors (to avoid overflows) */ + if (scaling_factor == -1) { /* mean energy for random sequences: 184.3*length cal */ + scaling_factor = exp(-(-185+(pf_params->temperature-37.)*7.27)/kT); + if (scaling_factor<1) scaling_factor=1; + pf_params->pf_scale = scaling_factor; + } + scale[0] = 1.; + scale[1] = 1./scaling_factor; + expMLbase[0] = 1; + expMLbase[1] = pf_params->expMLbase/scaling_factor; + for (i=2; i<=length; i++) { + scale[i] = scale[i/2]*scale[i-(i/2)]; + expMLbase[i] = pow(pf_params->expMLbase, (double)i) * scale[i]; + } +} + +/*----------------------------------------------------------------------*/ + +/*----------------------------------------------------------------------*/ + +/*---------------------------------------------------------------------------*/ + +PUBLIC void update_co_pf_params(int length){ + update_co_pf_params_par(length, NULL); +} + +PUBLIC void update_co_pf_params_par(int length, pf_paramT *parameters){ + make_pair_matrix(); + scale_pf_params((unsigned) length, parameters); +} + +/*---------------------------------------------------------------------------*/ +PRIVATE void make_ptypes(const short *S, const char *structure) { + int n,i,j,k,l; + int noLP = pf_params->model_details.noLP; + + n=S[0]; + for (k=1; k<=n-TURN-1; k++) + for (l=1; l<=2; l++) { + int type,ntype=0,otype=0; + i=k; j = i+TURN+l; + if (j>n) continue; + type = pair[S[i]][S[j]]; + while ((i>=1)&&(j<=n)) { + if ((i>1)&&(j=r) break; + } + if (l>j) nrerror("backtrack failed in qm1"); + backtrack(i,l); +} + +PRIVATE void backtrack(int i, int j) { + int noGUclosure = pf_params->model_details.noGUclosure; + + do { + double r, qbt1; + int k, l, type, u, u1; + + pstruc[i-1] = '('; pstruc[j-1] = ')'; + + r = urn() * qb[my_iindx[i]-j]; + type = ptype[my_iindx[i]-j]; + u = j-i-1; + /*hairpin contribution*/ + if (((type==3)||(type==4))&&noGUclosure) qbt1 = 0; + else + qbt1 = exp_E_Hairpin(u, type, S1[i+1], S1[j-1], sequence+i-1, pf_params)*scale[u+2]; + + if (qbt1>r) return; /* found the hairpin we're done */ + + for (k=i+1; k<=MIN2(i+MAXLOOP+1,j-TURN-2); k++) { + u1 = k-i-1; + for (l=MAX2(k+TURN+1,j-1-MAXLOOP+u1); l r) break; + } + if (qbt1 > r) break; + } + if (l=r) break; + } + if (k>=j) nrerror("backtrack failed, can't find split index "); + + backtrack_qm1(k, j); + + j = k-1; + while (j>i) { + /* now backtrack [i ... j] in qm[] */ + jj = jindx[j]; + ii = my_iindx[i]; + r = urn() * qm[ii - j]; + qt = qm1[jj+i]; k=i; + if (qt= r) break; + } + if (k>j) nrerror("backtrack failed in qm"); + + backtrack_qm1(k,j); + + if (k= r) break; /* no more pairs */ + j = k-1; + } + } +} + +PUBLIC void compute_probabilities(double FAB, double FA,double FB, + struct plist *prAB, + struct plist *prA, struct plist *prB, + int Alength) { + /*computes binding probabilities and dimer free energies*/ + int i, j; + double pAB; + double mykT; + struct plist *lp1, *lp2; + int offset; + + mykT=pf_params->kT/1000.; + + /* pair probabilities in pr are relative to the null model (without DuplexInit) */ + + /*Compute probabilities pAB, pAA, pBB*/ + + pAB=1.-exp((1/mykT)*(FAB-FA-FB)); + + /* compute pair probabilities given that it is a dimer */ + /* AB dimer */ + offset=0; + lp2=prA; + if (pAB>0) + for (lp1=prAB; lp1->j>0; lp1++) { + float pp=0; + i=lp1->i; j=lp1->j; + while (offset+lp2->i < i && lp2->i>0) lp2++; + if (offset+lp2->i == i) + while ((offset+lp2->j) < j && (lp2->j>0)) lp2++; + if (lp2->j == 0) {lp2=prB; offset=Alength;}/* jump to next list */ + if ((offset+lp2->i==i) && (offset+lp2->j ==j)) { + pp = lp2->p; + lp2++; + } + lp1->p=(lp1->p-(1-pAB)*pp)/pAB; + if(lp1->p < 0.){ + warn_user("part_func_co: numeric instability detected, probability below zero!"); + lp1->p = 0.; + } + } + return; +} + +PRIVATE double *Newton_Conc(double KAB, double KAA, double KBB, double concA, double concB,double* ConcVec) { + double TOL, EPS, xn, yn, det, cA, cB; + int i=0; + /*Newton iteration for computing concentrations*/ + cA=concA; + cB=concB; + TOL=1e-6; /*Tolerance for convergence*/ + ConcVec=(double*)space(5*sizeof(double)); /* holds concentrations */ + do { + /* det = (4.0 * KAA * cA + KAB *cB + 1.0) * (4.0 * KBB * cB + KAB *cA + 1.0) - (KAB *cB) * (KAB *cA); */ + det = 1 + 16. *KAA*KBB*cA*cB + KAB*(cA+cB) + 4.*KAA*cA + 4.*KBB*cB + 4.*KAB*(KBB*cB*cB + KAA*cA*cA); + /* xn = ( (2.0 * KBB * cB*cB + KAB *cA *cB + cB - concB) * (KAB *cA) - + (2.0 * KAA * cA*cA + KAB *cA *cB + cA - concA) * (4.0 * KBB * cB + KAB *cA + 1.0) ) /det; */ + xn = ( (2.0 * KBB * cB*cB + cB - concB) * (KAB *cA) - KAB*cA*cB*(4. * KBB*cB + 1.) - + (2.0 * KAA * cA*cA + cA - concA) * (4.0 * KBB * cB + KAB *cA + 1.0) ) /det; + /* yn = ( (2.0 * KAA * cA*cA + KAB *cA *cB + cA - concA) * (KAB *cB) - + (2.0 * KBB * cB*cB + KAB *cA *cB + cB - concB) * (4.0 * KAA * cA + KAB *cB + 1.0) ) /det; */ + yn = ( (2.0 * KAA * cA*cA + cA - concA) * (KAB *cB) - KAB*cA*cB*(4. * KAA*cA + 1.) - + (2.0 * KBB * cB*cB + cB - concB) * (4.0 * KAA * cA + KAB *cB + 1.0) ) /det; + EPS = fabs(xn/cA) + fabs(yn/cB); + cA += xn; + cB += yn; + i++; + if (i>10000) { + fprintf(stderr, "Newton did not converge after %d steps!!\n",i); + break; + } + } while(EPS>TOL); + + ConcVec[0]= cA*cB*KAB ;/*AB concentration*/ + ConcVec[1]= cA*cA*KAA ;/*AA concentration*/ + ConcVec[2]= cB*cB*KBB ;/*BB concentration*/ + ConcVec[3]= cA; /* A concentration*/ + ConcVec[4]= cB; /* B concentration*/ + + return ConcVec; +} + +PUBLIC struct ConcEnt *get_concentrations(double FcAB, double FcAA, double FcBB, double FEA, double FEB, double *startconc) +{ + /*takes an array of start concentrations, computes equilibrium concentrations of dimers, monomers, returns array of concentrations in strucutre ConcEnt*/ + double *ConcVec; + int i; + struct ConcEnt *Concentration; + double KAA, KAB, KBB, kT; + + kT=pf_params->kT/1000.; + Concentration=(struct ConcEnt *)space(20*sizeof(struct ConcEnt)); + /* Compute equilibrium constants */ + /* again note the input free energies are not from the null model (without DuplexInit) */ + + KAA = exp(( 2.0 * FEA - FcAA)/kT); + KBB = exp(( 2.0 * FEB - FcBB)/kT); + KAB = exp(( FEA + FEB - FcAB)/kT); + /* printf("Kaa..%g %g %g\n", KAA, KBB, KAB); */ + for (i=0; ((startconc[i]!=0)||(startconc[i+1]!=0));i+=2) { + ConcVec=Newton_Conc(KAB, KAA, KBB, startconc[i], startconc[i+1], ConcVec); + Concentration[i/2].A0=startconc[i]; + Concentration[i/2].B0=startconc[i+1]; + Concentration[i/2].ABc=ConcVec[0]; + Concentration[i/2].AAc=ConcVec[1]; + Concentration[i/2].BBc=ConcVec[2]; + Concentration[i/2].Ac=ConcVec[3]; + Concentration[i/2].Bc=ConcVec[4]; + + if (!(((i+2)/2)%20)) { + Concentration=(struct ConcEnt *)xrealloc(Concentration,((i+2)/2+20)*sizeof(struct ConcEnt)); + } + free(ConcVec); + } + + return Concentration; +} + +PUBLIC FLT_OR_DBL *export_co_bppm(void){ + return probs; +} + +/*###########################################*/ +/*# deprecated functions below #*/ +/*###########################################*/ + + +PUBLIC struct plist *get_plist(struct plist *pl, int length, double cut_off) { + int i, j,n, count; + /*get pair probibilities out of pr array*/ + count=0; + n=2; + for (i=1; i??*/ + pl[count++].p=0.; + pl=(struct plist *)xrealloc(pl,(count)*sizeof(struct plist)); + return pl; +} + +PUBLIC void init_co_pf_fold(int length){ /* DO NOTHING */ } diff --git a/cbits/utils.c b/cbits/utils.c new file mode 100644 --- /dev/null +++ b/cbits/utils.c @@ -0,0 +1,1154 @@ +/* + utils.c + + c Ivo L Hofacker and Walter Fontana + Vienna RNA package +*/ +/* Last changed Time-stamp: <2008-11-25 16:34:36 ivo> */ + +#include +#include +#include +#include +#include +#include +#include "config.h" // chzs +#include "utils.h" + +#ifdef WITH_DMALLOC +#include "dmalloc.h" +#endif + +#define PRIVATE static +#define PUBLIC + +/*@notnull@ @only@*/ +PUBLIC unsigned short xsubi[3]; + +PRIVATE char scale1[] = "....,....1....,....2....,....3....,....4"; +PRIVATE char scale2[] = "....,....5....,....6....,....7....,....8"; +PRIVATE char *inbuf = NULL; + +PRIVATE char *inbuf2 = NULL; +PRIVATE unsigned int typebuf2 = 0; + +/*-------------------------------------------------------------------------*/ + +PUBLIC void *space(unsigned size) { + void *pointer; + + if ( (pointer = (void *) calloc(1, (size_t) size)) == NULL) { +#ifdef EINVAL + if (errno==EINVAL) { + fprintf(stderr,"SPACE: requested size: %d\n", size); + nrerror("SPACE allocation failure -> EINVAL"); + } + if (errno==ENOMEM) +#endif + nrerror("SPACE allocation failure -> no memory"); + } + return pointer; +} + +#ifdef WITH_DMALLOC +#define space(S) calloc(1,(S)) +#endif + +#undef xrealloc +/* dmalloc.h #define's xrealloc */ +void *xrealloc (void *p, unsigned size) { + if (p == 0) + return space(size); + p = (void *) realloc(p, size); + if (p == NULL) { +#ifdef EINVAL + if (errno==EINVAL) { + fprintf(stderr,"xrealloc: requested size: %d\n", size); + nrerror("xrealloc allocation failure -> EINVAL"); + } + if (errno==ENOMEM) +#endif + nrerror("xrealloc allocation failure -> no memory"); + } + return p; +} + +/*------------------------------------------------------------------------*/ + +PUBLIC void nrerror(const char message[]) /* output message upon error */ +{ + fprintf(stderr, "ERROR: %s\n", message); + exit(EXIT_FAILURE); +} + +PUBLIC void warn_user(const char message[]){ + fprintf(stderr, "WARNING: %s\n", message); +} + +/*------------------------------------------------------------------------*/ +PUBLIC void init_rand(void) +{ + time_t t; + (void) time(&t); + xsubi[0] = xsubi[1] = xsubi[2] = (unsigned short) t; /* lower 16 bit */ + xsubi[1] += (unsigned short) ((unsigned)t >> 6); + xsubi[2] += (unsigned short) ((unsigned)t >> 12); +#ifndef HAVE_ERAND48 + srand((unsigned int) t); +#endif +} + +/*------------------------------------------------------------------------*/ + +PUBLIC double urn(void) + /* uniform random number generator; urn() is in [0,1] */ + /* uses a linear congruential library routine */ + /* 48 bit arithmetic */ +{ +#ifdef HAVE_ERAND48 + extern double erand48(unsigned short[]); + return erand48(xsubi); +#else + return ((double) rand())/RAND_MAX; +#endif +} + +/*------------------------------------------------------------------------*/ + +PUBLIC int int_urn(int from, int to) +{ + return ( ( (int) (urn()*(to-from+1)) ) + from ); +} + +/*------------------------------------------------------------------------*/ + +PUBLIC void filecopy(FILE *from, FILE *to) +{ + int c; + + while ((c = getc(from)) != EOF) (void)putc(c, to); +} + +/*-----------------------------------------------------------------*/ + +PUBLIC char *time_stamp(void) +{ + time_t cal_time; + + cal_time = time(NULL); + return ( ctime(&cal_time) ); +} + +/*-----------------------------------------------------------------*/ + +PUBLIC char *random_string(int l, const char symbols[]) +{ + char *r; + int i, rn, base; + + base = (int) strlen(symbols); + r = (char *) space(sizeof(char)*(l+1)); + + for (i = 0; i < l; i++) { + rn = (int) (urn()*base); /* [0, base-1] */ + r[i] = symbols[rn]; + } + r[l] = '\0'; + return r; +} + +/*-----------------------------------------------------------------*/ + +PUBLIC int hamming(const char *s1, const char *s2) +{ + int h=0; + + for (; *s1 && *s2; s1++, s2++) + if (*s1 != *s2) h++; + return h; +} + +PUBLIC int hamming_bound(const char *s1, const char *s2, int boundary) +{ + int h=0; + + for (; *s1 && *s2 && boundary; s1++, s2++, boundary--) + if (*s1 != *s2) h++; + return h; +} +/*-----------------------------------------------------------------*/ + +PUBLIC char *get_line(FILE *fp) /* reads lines of arbitrary length from fp */ +{ + char s[512], *line, *cp; + int len=0, size=0, l; + line=NULL; + do { + if (fgets(s, 512, fp)==NULL) break; + cp = strchr(s, '\n'); + if (cp != NULL) *cp = '\0'; + l = len + (int)strlen(s); + if (l+1>size) { + size = (int)((l+1)*1.2); + line = (char *) xrealloc(line, size*sizeof(char)); + } + strcat(line+len, s); + len=l; + } while(cp==NULL); + + return line; +} + +PUBLIC int skip_comment_lines(char **line){ + if((*line = get_line(stdin))==NULL) return -1; + + while((**line=='*')||(**line=='\0')){ + free(*line); + if((*line = get_line(stdin))==NULL) return -1; + } + return 0; +} + +PUBLIC unsigned int get_input_line(char **string, unsigned int option){ + char *line; + int i, l, r; + + /* + * read lines until informative data appears or + * report an error if anything goes wrong + */ + if((line = get_line(stdin))==NULL) return VRNA_INPUT_ERROR; + + if(!(option & VRNA_INPUT_NOSKIP_COMMENTS)) + while((*line=='*')||(*line=='\0')){ + free(line); + if((line = get_line(stdin))==NULL) return VRNA_INPUT_ERROR; + } + + l = (int) strlen(line); + + /* break on '@' sign if not disabled */ + if(*line == '@'){ + free(line); + return VRNA_INPUT_QUIT; + } + /* print line read if not disabled */ + /* if(!(option & VRNA_INPUT_NOPRINT)) printf("%s\n", line); */ + + /* eliminate whitespaces at the end of the line read */ + if(!(option & VRNA_INPUT_NO_TRUNCATION)){ + for(i = l-1; i >= 0; i--){ + if (line[i] == ' ') continue; + else if (line[i] == '\t') continue; + else break; + } + line[(i >= 0) ? (i+1) : 0] = '\0'; + } + + if(*line == '>'){ + /* fasta header */ + /* alloc memory for the string */ + *string = (char *) space(sizeof(char) * (strlen(line) + 1)); + r = VRNA_INPUT_FASTA_HEADER; + i = sscanf(line, ">%s", *string); + if(i > 0){ + i = (int) strlen(*string); + *string = (char *) xrealloc(*string, (i+1)*sizeof(char)); + free(line); + return r; + } + else{ + free(line); + free(*string); + *string = NULL; + return VRNA_INPUT_ERROR; + } + } + else{ + *string = strdup(line); + free(line); + } + return VRNA_INPUT_MISC; +} + +PUBLIC unsigned int get_multi_input_line(char **string, unsigned int option){ + char *line; + int i, l; + int state = 0; + int str_length = 0; + + line = (inbuf) ? inbuf : get_line(stdin); + inbuf = NULL; + do{ + + /* + * read lines until informative data appears or + * report an error if anything goes wrong + */ + if(!line) return VRNA_INPUT_ERROR; + + l = (int)strlen(line); + + /* eliminate whitespaces at the end of the line read */ + if(!(option & VRNA_INPUT_NO_TRUNCATION)){ + for(i = l-1; i >= 0; i--){ + if (line[i] == ' ') continue; + else if (line[i] == '\t') continue; + else break; + } + line[(i >= 0) ? (i+1) : 0] = '\0'; + } + + l = (int)strlen(line); + str_length = (*string) ? (int) strlen(*string) : 0; + + switch(*line){ + case '@': /* user abort */ + if(state) inbuf = line; + else free(line); + return (state==2) ? VRNA_INPUT_CONSTRAINT : (state==1) ? VRNA_INPUT_SEQUENCE : VRNA_INPUT_QUIT; + + case '\0': /* empty line */ + if(option & VRNA_INPUT_NOSKIP_BLANK_LINES){ + if(state) inbuf = line; + else free(line); + return (state==2) ? VRNA_INPUT_CONSTRAINT : (state==1) ? VRNA_INPUT_SEQUENCE : VRNA_INPUT_BLANK_LINE; + } + break; + + case '#': case '%': case ';': case '/': case '*': case ' ': + /* comments */ + if(option & VRNA_INPUT_NOSKIP_COMMENTS){ + if(state) inbuf = line; + else *string = line; + return (state == 2) ? VRNA_INPUT_CONSTRAINT : (state==1) ? VRNA_INPUT_SEQUENCE : VRNA_INPUT_COMMENT; + } + break; + + case '>': /* fasta header */ + if(state) inbuf = line; + else *string = line; + return (state==2) ? VRNA_INPUT_CONSTRAINT : (state==1) ? VRNA_INPUT_SEQUENCE : VRNA_INPUT_FASTA_HEADER; + + case 'x': case 'e': case 'l': case '&': /* seems to be a constraint or line starting with second sequence for dimer calculations */ + i = 1; + /* lets see if this assumption holds for the complete line */ + while((line[i] == 'x') || (line[i] == 'e') || (line[i] == 'l')) i++; + /* lines solely consisting of 'x's, 'e's or 'l's will be considered as structure constraint */ + + if( + ((line[i]>64) && (line[i]<91)) /* A-Z */ + || ((line[i]>96) && (line[i]<123)) /* a-z */ + ){ + if(option & VRNA_INPUT_FASTA_HEADER){ + /* are we in structure mode? Then we remember this line for the next round */ + if(state == 2){ inbuf = line; return VRNA_INPUT_CONSTRAINT;} + else{ + *string = (char *)xrealloc(*string, sizeof(char) * (str_length + l + 1)); + strcpy(*string + str_length, line); + state = 1; + } + break; + } + /* otherwise return line read */ + else{ *string = line; return VRNA_INPUT_SEQUENCE;} + } + /* mmmh? it really seems to be a constraint */ + /* fallthrough */ + case '<': case '.': case '|': case '(': case ')': case '[': case ']': case '{': case '}': case ',': case '+': + /* seems to be a structure or a constraint */ + /* either we concatenate this line to one that we read previously */ + if(option & VRNA_INPUT_FASTA_HEADER){ + if(state == 1){ + inbuf = line; + return VRNA_INPUT_SEQUENCE; + } + else{ + *string = (char *)xrealloc(*string, sizeof(char) * (str_length + l + 1)); + strcpy(*string + str_length, line); + state = 2; + } + } + /* or we return it as it is */ + else{ + *string = line; + return VRNA_INPUT_CONSTRAINT; + } + break; + default: if(option & VRNA_INPUT_FASTA_HEADER){ + /* are we already in sequence mode? */ + if(state == 2){ + inbuf = line; + return VRNA_INPUT_CONSTRAINT; + } + else{ + *string = (char *)xrealloc(*string, sizeof(char) * (str_length + l + 1)); + strcpy(*string + str_length, line); + state = 1; + } + } + /* otherwise return line read */ + else{ + *string = line; + return VRNA_INPUT_SEQUENCE; + } + } + free(line); + line = get_line(stdin); + }while(line); + + return (state==2) ? VRNA_INPUT_CONSTRAINT : (state==1) ? VRNA_INPUT_SEQUENCE : VRNA_INPUT_ERROR; +} + +PUBLIC unsigned int read_record(char **header, char **sequence, char ***rest, unsigned int options){ + unsigned int input_type, return_type, tmp_type; + int rest_count; + char *input_string; + + rest_count = 0; + return_type = tmp_type = 0; + input_string = *header = *sequence = NULL; + *rest = (char **)space(sizeof(char *)); + + /* remove unnecessary option flags from options variable... */ + options &= ~VRNA_INPUT_FASTA_HEADER; + + /* read first input or last buffered input */ + if(typebuf2){ + input_type = typebuf2; + input_string = inbuf2; + typebuf2 = 0; + inbuf2 = NULL; + } + else input_type = get_multi_input_line(&input_string, options); + + if(input_type & (VRNA_INPUT_QUIT | VRNA_INPUT_ERROR)) return input_type; + + /* skip everything until we read either a fasta header or a sequence */ + while(input_type & (VRNA_INPUT_MISC | VRNA_INPUT_CONSTRAINT | VRNA_INPUT_BLANK_LINE)){ + free(input_string); input_string = NULL; + input_type = get_multi_input_line(&input_string, options); + if(input_type & (VRNA_INPUT_QUIT | VRNA_INPUT_ERROR)) return input_type; + } + + if(input_type & VRNA_INPUT_FASTA_HEADER){ + return_type |= VRNA_INPUT_FASTA_HEADER; /* remember that we've read a fasta header */ + *header = input_string; + input_string = NULL; + /* get next data-block with fasta support if not explicitely forbidden by VRNA_INPUT_NO_SPAN */ + input_type = get_multi_input_line( + &input_string, + ((options & VRNA_INPUT_NO_SPAN) ? 0 : VRNA_INPUT_FASTA_HEADER) | options + ); + if(input_type & (VRNA_INPUT_QUIT | VRNA_INPUT_ERROR)) return (return_type | input_type); + } + + if(input_type & VRNA_INPUT_SEQUENCE){ + return_type |= VRNA_INPUT_SEQUENCE; /* remember that we've read a sequence */ + *sequence = input_string; + input_string = NULL; + } else nrerror("sequence input missing"); + + /* read the rest until we find user abort, EOF, new sequence or new fasta header */ + if(!(options & VRNA_INPUT_NO_REST)){ + options |= VRNA_INPUT_NOSKIP_COMMENTS; /* allow commetns to appear in rest output */ + tmp_type = VRNA_INPUT_QUIT | VRNA_INPUT_ERROR | VRNA_INPUT_SEQUENCE | VRNA_INPUT_FASTA_HEADER; + if(options & VRNA_INPUT_NOSKIP_BLANK_LINES) tmp_type |= VRNA_INPUT_BLANK_LINE; + while(!((input_type = get_multi_input_line(&input_string, options)) & tmp_type)){ + *rest = xrealloc(*rest, sizeof(char **)*(++rest_count + 1)); + (*rest)[rest_count-1] = input_string; + input_string = NULL; + } + /* + if(input_type & (VRNA_INPUT_QUIT | VRNA_INPUT_ERROR)) return input_type; + */ + + /* finished reading everything... + * we now put the last line into the buffer if necessary + * since it should belong to the next record + */ + inbuf2 = input_string; + typebuf2 = input_type; + } + (*rest)[rest_count] = NULL; + return (return_type); +} + + +/*-----------------------------------------------------------------*/ + +PUBLIC char *pack_structure(const char *struc) { + /* 5:1 compression using base 3 encoding */ + int i,j,l,pi; + unsigned char *packed; + + l = (int) strlen(struc); + packed = (unsigned char *) space(((l+4)/5+1)*sizeof(unsigned char)); + + j=i=pi=0; + while (i=0; k--) { + c = p % 3; + p /= 3; + struc[j+k] = code[c]; + } + j += 5; + } + struc[j--] = '\0'; + while (struc[j] == '(') /* strip trailing ( */ + struc[j--] = '\0'; + + return struc; +} + +/*--------------------------------------------------------------------------*/ + +PUBLIC short *make_pair_table(const char *structure) +{ + /* returns array representation of structure. + table[i] is 0 if unpaired or j if (i.j) pair. */ + short i,j,hx; + short length; + short *stack; + short *table; + + length = (short) strlen(structure); + stack = (short *) space(sizeof(short)*(length+1)); + table = (short *) space(sizeof(short)*(length+2)); + table[0] = length; + + for (hx=0, i=1; i<=length; i++) { + switch (structure[i-1]) { + case '(': + stack[hx++]=i; + break; + case ')': + j = stack[--hx]; + if (hx<0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + table[i]=j; + table[j]=i; + break; + default: /* unpaired base, usually '.' */ + table[i]= 0; + break; + } + } + if (hx!=0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + free(stack); + return(table); +} + +PUBLIC short *make_pair_table_pk(const char *structure){ + short i,j,hx, hx2; + short length; + short *stack; + short *stack2; + short *table; + + length = (short) strlen(structure); + stack = (short *) space(sizeof(short)*(length+1)); + stack2 = (short *) space(sizeof(short)*(length+1)); + table = (short *) space(sizeof(short)*(length+2)); + table[0] = length; + + for (hx=0, hx2=0, i=1; i<=length; i++) { + switch (structure[i-1]) { + case '(': + stack[hx++]=i; + break; + case ')': + j = stack[--hx]; + if (hx<0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced '()' brackets in make_pair_table_pk"); + } + table[i]=j; + table[j]=i; + break; + case '[': + stack2[hx2++]=i; + break; + case ']': + j = stack2[--hx2]; + if (hx2<0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced '[]' brackets in make_pair_table_pk"); + } + table[i]=j; + table[j]=i; + break; + default: /* unpaired base, usually '.' */ + table[i]= 0; + break; + } + } + if (hx!=0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced '()' brackets in make_pair_table_pk"); + } else if (hx2!=0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced '[]' brackets in make_pair_table_pk"); + } + free(stack); + free(stack2); + return(table); +} + +PUBLIC short *make_pair_table_snoop(const char *structure) +{ + /* returns array representation of structure. + table[i] is 0 if unpaired or j if (i.j) pair. */ + short i,j,hx; + short length; + short *stack; + short *table; + + length = (short) strlen(structure); + stack = (short *) space(sizeof(short)*(length+1)); + table = (short *) space(sizeof(short)*(length+2)); + table[0] = length; + + for (hx=0, i=1; i<=length; i++) { + switch (structure[i-1]) { + case '<': + stack[hx++]=i; + break; + case '>': + j = stack[--hx]; + if (hx<0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + table[i]=j; + table[j]=i; + break; + default: /* unpaired base, usually '.' */ + table[i]= table[i]; + break; + } + } + if (hx!=0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + free(stack); + return table ; +} + + +PUBLIC short *alimake_pair_table(const char *structure) +{ + /* returns array representation of structure. + table[i] is 0 if unpaired or j if (i.j) pair. */ + short i,j,hx; + short length; + short *stack; + short *table; + + length = (short) strlen(structure); + stack = (short *) space(sizeof(short)*(length+1)); + table = (short *) space(sizeof(short)*(length+2)); + table[0] = length; + + for (hx=0, i=1; i<=length; i++) { + switch (structure[i-1]) { + case '(': + stack[hx++]=i; + break; + case ')': + j = stack[--hx]; + if (hx<0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + table[i]=j; + table[j]=i; + break; + default: /* unpaired base, usually '.' */ + table[i]= 0; + break; + } + } + for (hx=0, i=1; i<=length; i++) { + switch (structure[i-1]) { + case '<': + stack[hx++]=i; + break; + case '>': + j = stack[--hx]; + if (hx<0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + table[i]=j; + table[j]=i; + break; + default: /* unpaired base, usually '.' */ + table[i]= table[i]; + break; + } + } + for (hx=0, i=1; i<=length; i++) { + switch (structure[i-1]) { + case '[': + stack[hx++]=i; + break; + case ']': + j = stack[--hx]; + if (hx<0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + table[i]=j; + table[j]=i; + break; + default: /* unpaired base, usually '.' */ + break; + } + } + if (hx!=0) { + fprintf(stderr, "%s\n", structure); + nrerror("unbalanced brackets in make_pair_table"); + } + free(stack); + return(table); +} + +PUBLIC short *copy_pair_table(const short *pt){ + short *table = (short *)space(sizeof(short) * (pt[0]+2)); + memcpy(table, pt, sizeof(short)*(pt[0]+2)); + return table; +} + + +PUBLIC int *make_loop_index_pt(short *pt){ + + /* number each position by which loop it belongs to (positions start + at 1) */ + int i,hx,l,nl; + int length; + int *stack = NULL; + int *loop = NULL; + + length = pt[0]; + stack = (int *) space(sizeof(int)*(length+1)); + loop = (int *) space(sizeof(int)*(length+2)); + hx=l=nl=0; + + for (i=1; i<=length; i++) { + if ((pt[i] != 0) && (i < pt[i])) { /* ( */ + nl++; l=nl; + stack[hx++]=i; + } + loop[i]=l; + + if ((pt[i] != 0) && (i > pt[i])) { /* ) */ + --hx; + if (hx>0) + l = loop[stack[hx-1]]; /* index of enclosing loop */ + else l=0; /* external loop has index 0 */ + if (hx<0) { + nrerror("unbalanced brackets in make_pair_table"); + } + } + } + loop[0] = nl; + free(stack); + return (loop); +} + +/*---------------------------------------------------------------------------*/ + +PUBLIC int bp_distance(const char *str1, const char *str2) +{ + /* dist = {number of base pairs in one structure but not in the other} */ + /* same as edit distance with pair_open pair_close as move set */ + int dist; + short i,l; + short *t1, *t2; + + dist = 0; + t1 = make_pair_table(str1); + t2 = make_pair_table(str2); + + l = (t1[0]i) dist++; + if (t2[i]>i) dist++; + } + free(t1); free(t2); + return dist; +} + +#ifndef HAVE_STRDUP +char *strdup(const char *s) { + char *dup; + + dup = space(strlen(s)+1); + strcpy(dup, s); + return(dup); +} +#endif + +PUBLIC void print_tty_input_seq(void){ + print_tty_input_seq_str("Input string (upper or lower case)"); +} + +PUBLIC void print_tty_input_seq_str(const char *s){ + printf("\n%s; @ to quit\n", s); + printf("%s%s\n", scale1, scale2); + (void) fflush(stdout); +} + +PUBLIC void print_tty_constraint_full(void){ + print_tty_constraint(VRNA_CONSTRAINT_PIPE | VRNA_CONSTRAINT_DOT | VRNA_CONSTRAINT_X | VRNA_CONSTRAINT_ANG_BRACK | VRNA_CONSTRAINT_RND_BRACK); +} + +PUBLIC void print_tty_constraint(unsigned int option){ + if(!(option & VRNA_CONSTRAINT_NO_HEADER)) printf("Input structure constraints using the following notation:\n"); + if(option & VRNA_CONSTRAINT_PIPE) printf("| : paired with another base\n"); + if(option & VRNA_CONSTRAINT_DOT) printf(". : no constraint at all\n"); + if(option & VRNA_CONSTRAINT_X) printf("x : base must not pair\n"); + if(option & VRNA_CONSTRAINT_ANG_BRACK) printf("< : base i is paired with a base j : base i is paired with a base j>i\n"); + if(option & VRNA_CONSTRAINT_RND_BRACK) printf("matching brackets ( ): base i pairs base j\n"); +} + +PUBLIC void str_DNA2RNA(char *sequence){ + unsigned int l, i; + if(sequence != NULL){ + l = strlen(sequence); + for(i = 0; i < l; i++){ + if(sequence[i] == 'T') sequence[i] = 'U'; + if(sequence[i] == 't') sequence[i] = 'u'; + } + } +} + +PUBLIC void str_uppercase(char *sequence){ + unsigned int l, i; + if(sequence){ + l = strlen(sequence); + for(i=0;i>1) + length + 1; + return idx; +} + +PUBLIC int *get_indx(unsigned int length){ + unsigned int i; + int *idx = (int *)space(sizeof(int) * (length+1)); + for (i = 1; i <= length; i++) + idx[i] = (i*(i-1)) >> 1; /* i(i-1)/2 */ + return idx; +} + +PUBLIC void getConstraint(char **cstruc, const char **lines, unsigned int option){ + int r, i, l, cl, stop; + char *c, *ptr; + if(lines){ + if(option & VRNA_CONSTRAINT_ALL) + option |= VRNA_CONSTRAINT_PIPE | VRNA_CONSTRAINT_ANG_BRACK | VRNA_CONSTRAINT_RND_BRACK | VRNA_CONSTRAINT_X | VRNA_CONSTRAINT_G; + + for(r=i=stop=0;lines[i];i++){ + l = (int)strlen(lines[i]); + c = (char *) space(sizeof(char) * (l+1)); + (void) sscanf(lines[i], "%s", c); + cl = (int)strlen(c); + /* line commented out ? */ + if((*c == '#') || (*c == '%') || (*c == ';') || (*c == '/') || (*c == '*' || (*c == '\0'))){ + /* skip leading comments only, i.e. do not allow comments inside the constraint */ + if(!r) continue; + else break; + } + + /* check current line for actual constraining structure */ + for(ptr = c;*c;c++){ + switch(*c){ + case '|': if(!(option & VRNA_CONSTRAINT_PIPE)){ + warn_user("constraints of type '|' not allowed"); + *c = '.'; + } + break; + case '<': + case '>': if(!(option & VRNA_CONSTRAINT_ANG_BRACK)){ + warn_user("constraints of type '<' or '>' not allowed"); + *c = '.'; + } + break; + case '(': + case ')': if(!(option & VRNA_CONSTRAINT_RND_BRACK)){ + warn_user("constraints of type '(' or ')' not allowed"); + *c = '.'; + } + break; + case 'x': if(!(option & VRNA_CONSTRAINT_X)){ + warn_user("constraints of type 'x' not allowed"); + *c = '.'; + } + break; + case '+': if(!(option & VRNA_CONSTRAINT_G)){ + warn_user("character '+' ignored in structure"); + *c = '.'; + } + case '.': break; + case '&': break; /* ignore concatenation char */ + default: warn_user("unrecognized character in constraint structure"); + break; + } + } + + r += cl+1; + *cstruc = (char *)xrealloc(*cstruc, r*sizeof(char)); + strcat(*cstruc, ptr); + free(ptr); + /* stop if not in fasta mode or multiple words on line */ + if(!(option & VRNA_CONSTRAINT_MULTILINE) || (cl != l)) break; + } + } +} + +PUBLIC char *extract_record_rest_structure( const char **lines, + unsigned int length, + unsigned int option){ + + char *structure = NULL; + int r, i, l, cl, stop; + char *c; + + if(lines){ + for(r = i = stop = 0; lines[i]; i++){ + l = (int)strlen(lines[i]); + c = (char *) space(sizeof(char) * (l+1)); + (void) sscanf(lines[i], "%s", c); + cl = (int)strlen(c); + + /* line commented out ? */ + if((*c == '#') || (*c == '%') || (*c == ';') || (*c == '/') || (*c == '*' || (*c == '\0'))){ + /* skip leading comments only, i.e. do not allow comments inside the constraint */ + if(!r) continue; + else break; + } + + /* append the structure part to the output */ + r += cl+1; + structure = (char *)xrealloc(structure, r*sizeof(char)); + strcat(structure, c); + free(c); + /* stop if the assumed structure length has been reached */ + if((length > 0) && (r-1 == length)) break; + /* stop if not allowed to read from multiple lines */ + if(!(option & VRNA_OPTION_MULTILINE)) break; + } + } + return structure; +} + + + +PUBLIC void constrain_ptypes(const char *constraint, unsigned int length, char *ptype, int *BP, int min_loop_size, unsigned int idx_type){ + int n,i,j,k,l; + int hx, *stack; + char type; + int *index; + + if(constraint == NULL) return; + + n = (int)strlen(constraint); + + stack = (int *) space(sizeof(int)*(n+1)); + + if(!idx_type){ /* index allows access in energy matrices at pos (i,j) via index[j]+i */ + index = get_indx(length); + + for(hx=0, j=1; j<=n; j++){ + switch(constraint[j-1]){ + case '|': if(BP) BP[j] = -1; + break; + case 'x': /* can't pair */ + for (l=1; l': /* pairs downstream */ + for (l=j+min_loop_size+1; l<=(int)length; l++) ptype[index[l]+j] = 0; + break; + } + } + } + else{ /* index allows access in energy matrices at pos (i,j) via index[i]-j */ + index = get_iindx(length); + + for(hx=0, j=1; j<=n; j++) { + switch (constraint[j-1]) { + case 'x': /* can't pair */ + for (l=1; l': /* pairs downstream */ + for (l=j+min_loop_size+1; l<=(int)length; l++) ptype[index[j]-l] = 0; + break; + } + } + } + if (hx!=0) { + fprintf(stderr, "%s\n", constraint); + nrerror("unbalanced brackets in constraint string"); + } + free(index); + free(stack); +} + +/* get a matrix containing the number of basepairs of a reference structure for each interval [i,j] with i= 1; i--) + for (j = i+turn+1; j <= length; j++){ + int bps; + ij = iindx[i]-j; + bps = array[ij+1]; + if((i<=(unsigned int)reference_pt[j]) && ((unsigned int)reference_pt[j] < j)) + bps++; + array[ij] = bps; + } + free(iindx); + return array; +} + +PUBLIC unsigned int *compute_BPdifferences(short *pt1, short *pt2, unsigned int turn){ + unsigned int *array; + unsigned int n, size, i, j, ij, d; + n = (unsigned int)pt1[0]; + size = ((n+1)*(n+2))/2; + array = (unsigned int *)space(sizeof(unsigned int) * size); + int *iindx = get_iindx(n); + for(i = n - turn - 1; i>=1; i--){ + d = 0; + for(j = i+turn+1; j <= n; j++){ + ij = iindx[i]-j; + d = array[ij+1]; + if(pt1[j] != pt2[j]){ + if(i <= (unsigned int)pt1[j] && (unsigned int)pt1[j] < j){ + /* we got an additional base pair in reference structure 1 */ + d++; + } + if(i <= (unsigned int)pt2[j] && (unsigned int)pt2[j] < j){ + /* we got another base pair in reference structure 2 */ + d++; + } + } + array[ij] = d; + + } + } + free(iindx); + return array; +} diff --git a/include/1.8.4_epars.h b/include/1.8.4_epars.h new file mode 100644 --- /dev/null +++ b/include/1.8.4_epars.h @@ -0,0 +1,366 @@ +#ifndef __VIENNA_RNA_PACKAGE_OLD_EPARS__ +#define __VIENNA_RNA_PACKAGE_OLD_EPARS__ +/** + \file 1.8.4_epars.h + \brief Free energy parameters for parameter file conversion + + This file contains the free energy parameters used in ViennaRNAPackage 1.8.4. + They are summarized in: + + D.H.Mathews, J. Sabina, M. ZUker, D.H. Turner + "Expanded sequence dependence of thermodynamic parameters improves + prediction of RNA secondary structure" + JMB, 288, pp 911-940, 1999 + + Enthalpies taken from: + + A. Walter, D Turner, J Kim, M Lyttle, P M"uller, D Mathews, M Zuker + "Coaxial stckaing of helices enhances binding of oligoribonucleotides.." + PNAS, 91, pp 9218-9222, 1994 + + D.H. Turner, N. Sugimoto, and S.M. Freier. + "RNA Structure Prediction", + Ann. Rev. Biophys. Biophys. Chem. 17, 167-192, 1988. + + John A.Jaeger, Douglas H.Turner, and Michael Zuker. + "Improved predictions of secondary structures for RNA", + PNAS, 86, 7706-7710, October 1989. + + L. He, R. Kierzek, J. SantaLucia, A.E. Walter, D.H. Turner + "Nearest-Neughbor Parameters for GU Mismatches...." + Biochemistry 1991, 30 11124-11132 + + A.E. Peritz, R. Kierzek, N, Sugimoto, D.H. Turner + "Thermodynamic Study of Internal Loops in Oligoribonucleotides..." + Biochemistry 1991, 30, 6428--6435 +*/ + +#define K0 273.15 +#ifdef INF +#undef INF +#endif +#define INF 1000000 +#define NBPAIRS 7 +#define NST 0 /* Energy for nonstandard stacked pairs */ +#define DEF -50 /* Default terminal mismatch, used for I */ + /* and any non_pairing bases */ +#define NSM 0 /* terminal mismatch for non standard pairs */ + +PRIVATE double Tmeasure_184 = 37 + K0; /* temperature of param measurements */ +PRIVATE double lxc37_184 = 107.856; /* parameter for logarithmic loop + energy extrapolation */ + +PRIVATE int stack37_184[NBPAIRS+1][NBPAIRS+1] = +/* CG GC GU UG AU UA */ +{ { INF, INF, INF, INF, INF, INF, INF, INF}, + { INF, -240, -330, -210, -140, -210, -210, NST}, + { INF, -330, -340, -250, -150, -220, -240, NST}, + { INF, -210, -250, 130, -50, -140, -130, NST}, + { INF, -140, -150, -50, 30, -60, -100, NST}, + { INF, -210, -220, -140, -60, -110, -90, NST}, + { INF, -210, -240, -130, -100, -90, -130, NST}, + { INF, NST, NST, NST, NST, NST, NST, NST}}; + +/* enthalpies (0.01*kcal/mol at 37 C) for stacked pairs */ +/* different from mfold-2.3, which uses values from mfold-2.2 */ +PRIVATE int enthalpies_184[NBPAIRS+1][NBPAIRS+1] = +/* CG GC GU UG AU UA */ +{ { INF, INF, INF, INF, INF, INF, INF, INF}, + { INF, -1060, -1340, -1210, -560, -1050, -1040, NST}, + { INF, -1340, -1490, -1260, -830, -1140, -1240, NST}, + { INF, -1210, -1260, -1460, -1350, -880, -1280, NST}, + { INF, -560, -830, -1350, -930, -320, -700, NST}, + { INF, -1050, -1140, -880, -320, -940, -680, NST}, + { INF, -1040, -1240, -1280, -700, -680, -770, NST}, + { INF, NST, NST, NST, NST, NST, NST, NST}}; + + +/* old values are here just for comparison */ +PRIVATE int oldhairpin37_184[31] = { /* from ViennaRNA 1.3 */ + INF, INF, INF, 410, 490, 440, 470, 500, 510, 520, 531, + 542, 551, 560, 568, 575, 582, 589, 595, 601, 606, + 611, 616, 621, 626, 630, 634, 638, 642, 646, 650}; + +PRIVATE int hairpin37_184[31] = { + INF, INF, INF, 570, 560, 560, 540, 590, 560, 640, 650, + 660, 670, 678, 686, 694, 701, 707, 713, 719, 725, + 730, 735, 740, 744, 749, 753, 757, 761, 765, 769}; + +PRIVATE int oldbulge37_184[31] = { + INF, 390, 310, 350, 420, 480, 500, 516, 531, 543, 555, + 565, 574, 583, 591, 598, 605, 612, 618, 624, 630, + 635, 640, 645, 649, 654, 658, 662, 666, 670, 673}; + +PRIVATE int bulge37_184[31] = { + INF, 380, 280, 320, 360, 400, 440, 459, 470, 480, 490, + 500, 510, 519, 527, 534, 541, 548, 554, 560, 565, + 571, 576, 580, 585, 589, 594, 598, 602, 605, 609}; + +PRIVATE int oldinternal_loop37_184[31] = { + INF, INF, 410, 510, 490, 530, 570, 587, 601, 614, 625, + 635, 645, 653, 661, 669, 676, 682, 688, 694, 700, + 705, 710, 715, 720, 724, 728, 732, 736, 740, 744}; + +PRIVATE int internal_loop37_184[31] = { + INF, INF, 410, 510, 170, 180, 200, 220, 230, 240, 250, + 260, 270, 278, 286, 294, 301, 307, 313, 319, 325, + 330, 335, 340, 345, 349, 353, 357, 361, 365, 369}; + +/* terminal mismatches */ +/* mismatch free energies for interior loops at 37C */ +PRIVATE int mismatchI37_184[NBPAIRS+1][5][5] = +{ /* @@ */ + {{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0}}, + { /* CG */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, 0, 0, -110, 0}, /* A@ AA AC AG AU */ + { 0, 0, 0, 0, 0}, /* C@ CA CC CG CU */ + { 0, -110, 0, 0, 0}, /* G@ GA GC GG GU */ + { 0, 0, 0, 0, -70}},/* U@ UA UC UG UU */ + { /* GC */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, 0, 0, -110, 0}, /* A@ AA AC AG AU */ + { 0, 0, 0, 0, 0}, /* C@ CA CC CG CU */ + { 0, -110, 0, 0, 0}, /* G@ GA GC GG GU */ + { 0, 0, 0, 0, -70}},/* U@ UA UC UG UU */ + { /* GU */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, 70, 70, -40, 70}, /* A@ AA AC AG AU */ + { 0, 70, 70, 70, 70}, /* C@ CA CC CG CU */ + { 0, -40, 70, 70, 70}, /* G@ GA GC GG GU */ + { 0, 70, 70, 70, 0}},/* U@ UA UC UG UU */ + { /* UG */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, 70, 70, -40, 70}, /* A@ AA AC AG AU */ + { 0, 70, 70, 70, 70}, /* C@ CA CC CG CU */ + { 0, -40, 70, 70, 70}, /* G@ GA GC GG GU */ + { 0, 70, 70, 70, 0}},/* U@ UA UC UG UU */ + { /* AU */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, 70, 70, -40, 70}, /* A@ AA AC AG AU */ + { 0, 70, 70, 70, 70}, /* C@ CA CC CG CU */ + { 0, -40, 70, 70, 70}, /* G@ GA GC GG GU */ + { 0, 70, 70, 70, 0}},/* U@ UA UC UG UU */ + { /* UA */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, 70, 70, -40, 70}, /* A@ AA AC AG AU */ + { 0, 70, 70, 70, 70}, /* C@ CA CC CG CU */ + { 0, -40, 70, 70, 70}, /* G@ GA GC GG GU */ + { 0, 70, 70, 70, 0}},/* U@ UA UC UG UU */ + { /* @@ */ + { 90, 90, 90, 90, 90},{ 90, 90, 90, 90,-20},{ 90, 90, 90, 90, 90}, + { 90,-20, 90, 90, 90},{ 90, 90, 90, 90, 20}} +}; + +/* mismatch free energies for hairpins at 37C */ +PRIVATE int mismatchH37_184[NBPAIRS+1][5][5] = +{ /* @@ */ + {{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0}}, + { /* CG */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { -90, -150, -150, -140, -180}, /* A@ AA AC AG AU */ + { -90, -100, -90, -290, -80}, /* C@ CA CC CG CU */ + { -90, -220, -200, -160, -110}, /* G@ GA GC GG GU */ + { -90, -170, -140, -180, -200}},/* U@ UA UC UG UU */ + { /* GC */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { -70, -110, -150, -130, -210}, /* A@ AA AC AG AU */ + { -70, -110, -70, -240, -50}, /* C@ CA CC CG CU */ + { -70, -240, -290, -140, -120}, /* G@ GA GC GG GU */ + { -70, -190, -100, -220, -150}},/* U@ UA UC UG UU */ + { /* GU */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, 20, -50, -30, -30}, /* A@ AA AC AG AU */ + { 0, -10, -20, -150, -20}, /* C@ CA CC CG CU */ + { 0, -90, -110, -30, 0}, /* G@ GA GC GG GU */ + { 0, -30, -30, -40, -110}},/* U@ UA UC UG UU */ + { /* UG */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, -50, -30, -60, -50}, /* A@ AA AC AG AU */ + { 0, -20, -10, -170, 0}, /* C@ CA CC CG CU */ + { 0, -80, -120, -30, -70}, /* G@ GA GC GG GU */ + { 0, -60, -10, -60, -80}},/* U@ UA UC UG UU */ + { /* AU */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, -30, -50, -30, -30}, /* A@ AA AC AG AU */ + { 0, -10, -20, -150, -20}, /* C@ CA CC CG CU */ + { 0, -110, -120, -20, 20}, /* G@ GA GC GG GU */ + { 0, -30, -30, -60, -110}},/* U@ UA UC UG UU */ + { /* UA */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { 0, -50, -30, -60, -50}, /* A@ AA AC AG AU */ + { 0, -20, -10, -120, -0}, /* C@ CA CC CG CU */ + { 0, -140, -120, -70, -20}, /* G@ GA GC GG GU */ + { 0, -30, -10, -50, -80}},/* U@ UA UC UG UU */ + { /* @@ */ + { 0, 0, 0, 0, 0},{ 0, 0, 0, 0, 0},{ 0, 0, 0, 0, 0}, + { 0, 0, 0, 0, 0},{ 0, 0, 0, 0, 0}} +}; + +/* mismatch energies in multiloops */ +PRIVATE int mismatchM37_184[NBPAIRS+1][5][5]; + +/* these are probably junk */ +/* mismatch enthalpies for temperature scaling */ +PRIVATE int mism_H_184[NBPAIRS+1][5][5] = +{ /* no pair */ + {{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0},{0,0,0,0,0}}, + { /* CG */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { DEF,-1030, -950,-1030,-1030}, /* A@ AA AC AG AU */ + { DEF, -520, -450, -520, -670}, /* C@ CA CC CG CU */ + { DEF, -940, -940, -940, -940}, /* G@ GA GC GG GU */ + { DEF, -810, -740, -810, -860}},/* U@ UA UC UG UU */ + { /* GC */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { DEF, -520, -880, -560, -880}, /* A@ AA AC AG AU */ + { DEF, -720, -310, -310, -390}, /* C@ CA CC CG CU */ + { DEF, -710, -740, -620, -740}, /* G@ GA GC GG GU */ + { DEF, -500, -500, -500, -570}},/* U@ UA UC UG UU */ + { /* GU */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { DEF, -430, -600, -600, -600}, /* A@ AA AC AG AU */ + { DEF, -260, -240, -240, -240}, /* C@ CA CC CG CU */ + { DEF, -340, -690, -690, -690}, /* G@ GA GC GG GU */ + { DEF, -330, -330, -330, -330}},/* U@ UA UC UG UU */ + { /* UG */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { DEF, -720, -790, -960, -810}, /* A@ AA AC AG AU */ + { DEF, -480, -480, -360, -480}, /* C@ CA CC CG CU */ + { DEF, -660, -810, -920, -810}, /* G@ GA GC GG GU */ + { DEF, -550, -440, -550, -360}},/* U@ UA UC UG UU */ + { /* AU */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { DEF, -430, -600, -600, -600}, /* A@ AA AC AG AU */ + { DEF, -260, -240, -240, -240}, /* C@ CA CC CG CU */ + { DEF, -340, -690, -690, -690}, /* G@ GA GC GG GU */ + { DEF, -330, -330, -330, -330}},/* U@ UA UC UG UU */ + { /* UA */ + { 0, 0, 0, 0, 0}, /* @@ @A @C @G @U */ + { DEF, -400, -630, -890, -590}, /* A@ AA AC AG AU */ + { DEF, -430, -510, -200, -180}, /* C@ CA CC CG CU */ + { DEF, -380, -680, -890, -680}, /* G@ GA GC GG GU */ + { DEF, -280, -140, -280, -140}},/* U@ UA UC UG UU */ + { /* nonstandard pair */ + {DEF,DEF,DEF,DEF,DEF},{DEF,DEF,DEF,DEF,DEF},{DEF,DEF,DEF,DEF,DEF}, + {DEF,DEF,DEF,DEF,DEF},{DEF,DEF,DEF,DEF,DEF}} +}; + +/* 5' dangling ends (unpaird base stacks on first paired base) */ +PRIVATE int dangle5_37_184[NBPAIRS+1][5]= +{/* @ A C G U */ + { INF, INF, INF, INF, INF}, /* no pair */ + { INF, -50, -30, -20, -10}, /* CG (stacks on C) */ + { INF, -20, -30, -0, -0}, /* GC (stacks on G) */ + { INF, -30, -30, -40, -20}, /* GU */ + { INF, -30, -10, -20, -20}, /* UG */ + { INF, -30, -30, -40, -20}, /* AU */ + { INF, -30, -10, -20, -20}, /* UA */ + { 0, 0, 0, 0, 0} /* @ */ +}; + +/* 3' dangling ends (unpaired base stacks on second paired base */ +PRIVATE int dangle3_37_184[NBPAIRS+1][5]= +{/* @ A C G U */ + { INF, INF, INF, INF, INF}, /* no pair */ + { INF, -110, -40, -130, -60}, /* CG (stacks on G) */ + { INF, -170, -80, -170, -120}, /* GC */ + { INF, -70, -10, -70, -10}, /* GU */ + { INF, -80, -50, -80, -60}, /* UG */ + { INF, -70, -10, -70, -10}, /* AU */ + { INF, -80, -50, -80, -60}, /* UA */ + { 0, 0, 0, 0, 0} /* @ */ +}; + +/* enthalpies for temperature scaling */ +PRIVATE int dangle3_H_184[NBPAIRS+1][5] = +{/* @ A C G U */ + { INF, INF, INF, INF, INF}, /* no pair */ + { 0, -740, -280, -640, -360}, + { 0, -900, -410, -860, -750}, + { 0, -740, -240, -720, -490}, + { 0, -490, -90, -550, -230}, + { 0, -570, -70, -580, -220}, + { 0, -490, -90, -550, -230}, + { 0, 0, 0, 0, 0} +}; + +PRIVATE int dangle5_H_184[NBPAIRS+1][5] = +{/* @ A C G U */ + { INF, INF, INF, INF, INF}, /* no pair */ + { 0, -240, 330, 80, -140}, + { 0, -160, 70, -460, -40}, + { 0, 160, 220, 70, 310}, + { 0, -150, 510, 10, 100}, + { 0, 160, 220, 70, 310}, + { 0, -50, 690, -60, -60}, + { 0, 0, 0, 0, 0} +}; + + +/* constants for linearly destabilizing contributions for multi-loops + F = ML_closing + ML_intern*k + ML_BASE*u */ +/* old versions erroneously used ML_intern*(k-1) */ +PRIVATE int ML_BASE37_184 = 0; +PRIVATE int ML_closing37_184 = 340; +PRIVATE int ML_intern37_184 = 40; + +/* Ninio-correction for asymmetric internal loops with branches n1 and n2 */ +/* ninio_energy = min{max_ninio, |n1-n2|*F_ninio[min{4.0, n1, n2}] } */ +PRIVATE int MAX_NINIO_184 = 300; /* maximum correction */ +PRIVATE int F_ninio37_184[5] = { 0, 40, 50, 20, 10 }; /* only F[2] used */ + +/* stabilizing contribution due to special hairpins of size 4 (tetraloops) */ + +PRIVATE char Tetraloops_184[1400] = /* place for up to 200 tetra loops */ + "GGGGAC " + "GGUGAC " + "CGAAAG " + "GGAGAC " + "CGCAAG " + "GGAAAC " + "CGGAAG " + "CUUCGG " + "CGUGAG " + "CGAAGG " + "CUACGG " + "GGCAAC " + "CGCGAG " + "UGAGAG " + "CGAGAG " + "AGAAAU " + "CGUAAG " + "CUAACG " + "UGAAAG " + "GGAAGC " + "GGGAAC " + "UGAAAA " + "AGCAAU " + "AGUAAU " + "CGGGAG " + "AGUGAU " + "GGCGAC " + "GGGAGC " + "GUGAAC " + "UGGAAA " +; + +PRIVATE int TETRA_ENERGY37_184[200] = { + -300, -300, -300, -300, -300, -300, -300, -300, -300, -250, -250, -250, + -250, -250, -200, -200, -200, -200, -200, -150, -150, -150, -150, -150, + -150, -150, -150, -150, -150, -150}; + +PRIVATE int TETRA_ENTH37_184 = -400; + +PRIVATE char Triloops_184[241] = ""; + +PRIVATE int Triloop_E37_184[40]; + +/* penalty for AU (or GU) terminating helix) */ +/* mismatches already contain these */ +PRIVATE int TerminalAU_184 = 50; + +/* penalty for forming a bi-molecular duplex */ +PRIVATE int DuplexInit_184 = 410; + +#endif diff --git a/include/1.8.4_intloops.h b/include/1.8.4_intloops.h new file mode 100644 --- /dev/null +++ b/include/1.8.4_intloops.h @@ -0,0 +1,11073 @@ +/** +*** \file 1.8.4_intloops.h +*** \brief Free energy parameters for interior loop contributions needed by the parameter file conversion functions +**/ +PRIVATE int int11_37_184[NBPAIRS+1][NBPAIRS+1][5][5] = +{ /* noPair */ {{{0}}}, +{ /* noPair */ {{0}}, +/* CG..CG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 40, 40, 40}, +{ 110, 40, 40, 40, 40}, +{ 110, 40, 40, -140, 40}, +{ 110, 40, 40, 40, 40} +}, +/* CG..GC */ +{{ 110, 110, 110, 110, 110}, +{ 110, 40, -40, 40, 40}, +{ 110, 30, 50, 40, 50}, +{ 110, -10, 40, -170, 40}, +{ 110, 40, 0, 40, -30} +}, +/* CG..GU */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* CG..UG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* CG..AU */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* CG..UA */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* CG..?? */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110} +} +}, +{ /* noPair */ {{0}}, +/* GC..CG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 40, 30, -10, 40}, +{ 110, -40, 50, 40, 0}, +{ 110, 40, 40, -170, 40}, +{ 110, 40, 50, 40, -30} +}, +/* GC..GC */ +{{ 110, 110, 110, 110, 110}, +{ 110, 80, 40, 40, 40}, +{ 110, 40, 40, 40, 40}, +{ 110, 40, 40, -210, 40}, +{ 110, 40, 40, 40, -70} +}, +/* GC..GU */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* GC..UG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* GC..AU */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 100} +}, +/* GC..UA */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* GC..?? */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110} +} +}, +{ /* noPair */ {{0}}, +/* GU..CG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* GU..GC */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* GU..GU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* GU..UG */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* GU..AU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* GU..UA */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* GU..?? */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +} +}, +{ /* noPair */ {{0}}, +/* UG..CG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* UG..GC */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* UG..GU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* UG..UG */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* UG..AU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* UG..UA */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* UG..?? */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +} +}, +{ /* noPair */ {{0}}, +/* AU..CG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* AU..GC */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 100} +}, +/* AU..GU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* AU..UG */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* AU..AU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 120} +}, +/* AU..UA */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 150} +}, +/* AU..?? */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +} +}, +{ /* noPair */ {{0}}, +/* UA..CG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* UA..GC */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, -100, 110}, +{ 110, 110, 110, 110, 110} +}, +/* UA..GU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* UA..UG */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 170} +}, +/* UA..AU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 150} +}, +/* UA..UA */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, -40, 170}, +{ 170, 170, 170, 170, 180} +}, +/* UA..?? */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +} +}, +{ /* noPair */ {{0}}, +/* ??..CG */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110} +}, +/* ??..GC */ +{{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110}, +{ 110, 110, 110, 110, 110} +}, +/* ??..GU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +}, +/* ??..UG */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +}, +/* ??..AU */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +}, +/* ??..UA */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +}, +/* ??..?? */ +{{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170}, +{ 170, 170, 170, 170, 170} +} +} +}; + +PRIVATE int int11_H_184[NBPAIRS+1][NBPAIRS+1][5][5] = + /* GC..GC */ +{ /* noPair */ {{{0}}}, +{ /* noPair */ {{0}}, +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GC..CG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GC..GU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GC..UG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GC..AU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GC..UA */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GC.. @ */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}}, + /* CG..GC */ +{ /* noPair */ {{0}}, +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* CG..CG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* CG..GU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* CG..UG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* CG..AU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* CG..UA */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* CG.. @ */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}}, + /* GU..GC */ +{ /* noPair */ {{0}}, +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GU..CG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GU..GU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GU..UG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GU..AU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GU..UA */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* GU.. @ */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}}, + /* UG..GC */ +{ /* noPair */ {{0}}, +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UG..CG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UG..GU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UG..UG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UG..AU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UG..UA */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UG.. @ */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}}, + /* AU..GC */ +{ /* noPair */ {{0}}, +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* AU..CG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* AU..GU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* AU..UG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* AU..AU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* AU..UA */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* AU.. @ */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}}, + /* UA..GC */ +{ /* noPair */ {{0}}, +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UA..CG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UA..GU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UA..UG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UA..AU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UA..UA */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* UA.. @ */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}}, + /* @..GC */ +{ /* noPair */ {{0}}, +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* @..CG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* @..GU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* @..UG */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* @..AU */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* @..UA */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}, + /* @.. @ */ +{ { 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}, +{ 0, 0, 0, 0, 0}}}}; + +PRIVATE int int21_37_184[NBPAIRS+1][NBPAIRS+1][5][5][5] = +{ /* noPair */ {{{{0}}}}, +{ /* noPair */ {{{0}}}, +{ +/* CG.@..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.A..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 240, 220, 160, 400},{ 550, 210, 170, 160, 400},{ 550, 100, 60, 40, 400},{ 550, 400, 400, 400, 400}}, +/* CG.C..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 230, 220, 400, 220},{ 550, 220, 250, 400, 220},{ 550, 400, 400, 400, 400},{ 550, 250, 190, 400, 220}}, +/* CG.G..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 170, 400, 80, 400},{ 550, 400, 400, 400, 400},{ 550, 80, 400, 220, 400},{ 550, 400, 400, 400, 400}}, +/* CG.U..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 400, 400, 400, 400},{ 550, 400, 220, 400, 130},{ 550, 400, 400, 400, 400},{ 550, 400, 170, 400, 120}} +}, +{ +/* CG.@..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.A..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 230, 220, 110, 400},{ 550, 210, 170, 160, 400},{ 550, 80, 60, 40, 400},{ 550, 400, 400, 400, 400}}, +/* CG.C..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 230, 220, 400, 220},{ 550, 220, 250, 400, 220},{ 550, 400, 400, 400, 400},{ 550, 250, 190, 400, 220}}, +/* CG.G..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 170, 400, 80, 400},{ 550, 400, 400, 400, 400},{ 550, 80, 400, 220, 400},{ 550, 400, 400, 400, 400}}, +/* CG.U..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 400, 400, 400, 400},{ 550, 400, 220, 400, 150},{ 550, 400, 400, 400, 400},{ 550, 400, 170, 400, 120}} +}, +{ +/* CG.@..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.A..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* CG.C..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* CG.G..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* CG.U..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* CG.@..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.A..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* CG.C..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* CG.G..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* CG.U..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* CG.@..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.A..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* CG.C..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* CG.G..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* CG.U..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* CG.@..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.A..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* CG.C..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* CG.G..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* CG.U..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* CG.@..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.A..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.C..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.G..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* CG.U..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* GC.@..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.A..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 220, 210, 400},{ 550, 210, 170, 160, 400},{ 550, 120, 60, 40, 400},{ 550, 400, 400, 400, 400}}, +/* GC.C..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 230, 220, 400, 220},{ 550, 220, 250, 400, 220},{ 550, 400, 400, 400, 400},{ 550, 250, 190, 400, 220}}, +/* GC.G..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 170, 400, 80, 400},{ 550, 400, 400, 400, 400},{ 550, 80, 400, 220, 400},{ 550, 400, 400, 400, 400}}, +/* GC.U..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 400, 400, 400, 400},{ 550, 400, 220, 400, 120},{ 550, 400, 400, 400, 400},{ 550, 400, 170, 400, 120}} +}, +{ +/* GC.@..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.A..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 240, 220, 160, 400},{ 550, 210, 170, 160, 400},{ 550, 100, 60, 40, 400},{ 550, 400, 400, 400, 400}}, +/* GC.C..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 230, 220, 400, 220},{ 550, 220, 250, 400, 220},{ 550, 400, 400, 400, 400},{ 550, 250, 190, 400, 220}}, +/* GC.G..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 170, 400, 80, 400},{ 550, 400, 400, 400, 400},{ 550, 80, 400, 220, 400},{ 550, 400, 400, 400, 400}}, +/* GC.U..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 400, 400, 400, 400},{ 550, 400, 220, 400, 130},{ 550, 400, 400, 400, 400},{ 550, 400, 170, 400, 120}} +}, +{ +/* GC.@..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.A..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* GC.C..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* GC.G..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* GC.U..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* GC.@..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.A..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* GC.C..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* GC.G..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* GC.U..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* GC.@..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.A..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* GC.C..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* GC.G..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* GC.U..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* GC.@..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.A..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* GC.C..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* GC.G..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* GC.U..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* GC.@..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.A..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.C..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.G..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GC.U..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* GU.@..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.A..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* GU.C..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* GU.G..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* GU.U..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* GU.@..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.A..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* GU.C..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* GU.G..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* GU.U..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* GU.@..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.A..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* GU.C..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* GU.G..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* GU.U..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* GU.@..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.A..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* GU.C..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* GU.G..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* GU.U..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* GU.@..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.A..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* GU.C..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* GU.G..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* GU.U..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* GU.@..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.A..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* GU.C..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* GU.G..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* GU.U..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* GU.@..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.A..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.C..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.G..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* GU.U..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* UG.@..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.A..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* UG.C..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* UG.G..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* UG.U..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* UG.@..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.A..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* UG.C..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* UG.G..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* UG.U..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* UG.@..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.A..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UG.C..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UG.G..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UG.U..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UG.@..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.A..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UG.C..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UG.G..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UG.U..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UG.@..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.A..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UG.C..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UG.G..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UG.U..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UG.@..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.A..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UG.C..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UG.G..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UG.U..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UG.@..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.A..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.C..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.G..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UG.U..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* AU.@..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.A..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* AU.C..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* AU.G..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* AU.U..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* AU.@..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.A..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* AU.C..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* AU.G..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* AU.U..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* AU.@..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.A..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* AU.C..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* AU.G..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* AU.U..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* AU.@..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.A..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* AU.C..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* AU.G..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* AU.U..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* AU.@..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.A..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* AU.C..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* AU.G..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* AU.U..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* AU.@..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.A..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* AU.C..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* AU.G..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* AU.U..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* AU.@..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.A..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.C..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.G..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* AU.U..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* UA.@..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.A..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* UA.C..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* UA.G..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* UA.U..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* UA.@..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.A..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 300, 240, 480},{ 550, 290, 250, 240, 480},{ 550, 180, 140, 120, 480},{ 550, 480, 480, 480, 480}}, +/* UA.C..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 310, 300, 480, 300},{ 550, 300, 330, 480, 300},{ 550, 480, 480, 480, 480},{ 550, 330, 270, 480, 300}}, +/* UA.G..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 250, 480, 160, 480},{ 550, 480, 480, 480, 480},{ 550, 160, 480, 300, 480},{ 550, 480, 480, 480, 480}}, +/* UA.U..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 480, 480, 480, 480},{ 550, 480, 300, 480, 210},{ 550, 480, 480, 480, 480},{ 550, 480, 250, 480, 200}} +}, +{ +/* UA.@..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.A..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UA.C..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UA.G..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UA.U..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UA.@..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.A..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UA.C..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UA.G..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UA.U..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UA.@..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.A..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UA.C..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UA.G..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UA.U..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UA.@..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.A..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 390, 370, 310, 550},{ 550, 360, 320, 310, 550},{ 550, 250, 210, 190, 550},{ 550, 550, 550, 550, 550}}, +/* UA.C..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 380, 370, 550, 370},{ 550, 370, 400, 550, 370},{ 550, 550, 550, 550, 550},{ 550, 400, 340, 550, 370}}, +/* UA.G..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 320, 550, 230, 550},{ 550, 550, 550, 550, 550},{ 550, 230, 550, 370, 550},{ 550, 550, 550, 550, 550}}, +/* UA.U..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 370, 550, 280},{ 550, 550, 550, 550, 550},{ 550, 550, 320, 550, 270}} +}, +{ +/* UA.@..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.A..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.C..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.G..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* UA.U..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* ??.@..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.A..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.C..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.G..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.U..GC */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +}, +{ +/* ??.@..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.A..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.C..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.G..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.U..CG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +}, +{ +/* ??.@..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.A..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.C..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.G..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.U..UG */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +}, +{ +/* ??.@..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.A..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.C..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.G..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.U..GU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +}, +{ +/* ??.@..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.A..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.C..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.G..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.U..UA */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +}, +{ +/* ??.@..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.A..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.C..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.G..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.U..AU */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +}, +{ +/* ??.@..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.A..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.C..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.G..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}}, +/* ??.U..?? */ +{{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550},{ 550, 550, 550, 550, 550}} +} +} +}; + +PRIVATE int int21_H_184[NBPAIRS+1][NBPAIRS+1][5][5][5] = +{ /* noPair */ {{{{0}}}}, +{ /* noPair */ {{{0}}}, +{ +/* CG.@..CG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.A..CG */ +{{ DEF,-1029, -949,-1029,-1029},{-1079,-2058,-1978,-2058,-2058},{ -569,-1548,-1468,-1548,-1548},{ -989,-1968,-1888,-1968,-1968},{ -859,-1838,-1758,-1838,-1838}}, +/* CG.C..CG */ +{{ DEF, -519, -449, -519, -669},{ -999,-1468,-1398,-1468,-1618},{ -499, -968, -898, -968,-1118},{ -989,-1458,-1388,-1458,-1608},{ -789,-1258,-1188,-1258,-1408}}, +/* CG.G..CG */ +{{ DEF, -939, -939, -939, -939},{-1079,-1968,-1968,-1968,-1968},{ -569,-1458,-1458,-1458,-1458},{ -989,-1878,-1878,-1878,-1878},{ -859,-1748,-1748,-1748,-1748}}, +/* CG.U..CG */ +{{ DEF, -809, -739, -809, -859},{-1079,-1838,-1768,-1838,-1888},{ -719,-1478,-1408,-1478,-1528},{ -989,-1748,-1678,-1748,-1798},{ -909,-1668,-1598,-1668,-1718}} +}, +{ +/* CG.@..GC */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.A..GC */ +{{ DEF,-1029, -949,-1029,-1029},{ -569,-1548,-1468,-1548,-1548},{ -769,-1748,-1668,-1748,-1748},{ -759,-1738,-1658,-1738,-1738},{ -549,-1528,-1448,-1528,-1528}}, +/* CG.C..GC */ +{{ DEF, -519, -449, -519, -669},{ -929,-1398,-1328,-1398,-1548},{ -359, -828, -758, -828, -978},{ -789,-1258,-1188,-1258,-1408},{ -549,-1018, -948,-1018,-1168}}, +/* CG.G..GC */ +{{ DEF, -939, -939, -939, -939},{ -609,-1498,-1498,-1498,-1498},{ -359,-1248,-1248,-1248,-1248},{ -669,-1558,-1558,-1558,-1558},{ -549,-1438,-1438,-1438,-1438}}, +/* CG.U..GC */ +{{ DEF, -809, -739, -809, -859},{ -929,-1688,-1618,-1688,-1738},{ -439,-1198,-1128,-1198,-1248},{ -789,-1548,-1478,-1548,-1598},{ -619,-1378,-1308,-1378,-1428}} +}, +{ +/* CG.@..GU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.A..GU */ +{{ DEF,-1029, -949,-1029,-1029},{ -479,-1458,-1378,-1458,-1458},{ -309,-1288,-1208,-1288,-1288},{ -389,-1368,-1288,-1368,-1368},{ -379,-1358,-1278,-1358,-1358}}, +/* CG.C..GU */ +{{ DEF, -519, -449, -519, -669},{ -649,-1118,-1048,-1118,-1268},{ -289, -758, -688, -758, -908},{ -739,-1208,-1138,-1208,-1358},{ -379, -848, -778, -848, -998}}, +/* CG.G..GU */ +{{ DEF, -939, -939, -939, -939},{ -649,-1538,-1538,-1538,-1538},{ -289,-1178,-1178,-1178,-1178},{ -739,-1628,-1628,-1628,-1628},{ -379,-1268,-1268,-1268,-1268}}, +/* CG.U..GU */ +{{ DEF, -809, -739, -809, -859},{ -649,-1408,-1338,-1408,-1458},{ -289,-1048, -978,-1048,-1098},{ -739,-1498,-1428,-1498,-1548},{ -379,-1138,-1068,-1138,-1188}} +}, +{ +/* CG.@..UG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.A..UG */ +{{ DEF,-1029, -949,-1029,-1029},{ -769,-1748,-1668,-1748,-1748},{ -529,-1508,-1428,-1508,-1508},{ -709,-1688,-1608,-1688,-1688},{ -599,-1578,-1498,-1578,-1578}}, +/* CG.C..UG */ +{{ DEF, -519, -449, -519, -669},{ -839,-1308,-1238,-1308,-1458},{ -529, -998, -928, -998,-1148},{ -859,-1328,-1258,-1328,-1478},{ -489, -958, -888, -958,-1108}}, +/* CG.G..UG */ +{{ DEF, -939, -939, -939, -939},{-1009,-1898,-1898,-1898,-1898},{ -409,-1298,-1298,-1298,-1298},{ -969,-1858,-1858,-1858,-1858},{ -599,-1488,-1488,-1488,-1488}}, +/* CG.U..UG */ +{{ DEF, -809, -739, -809, -859},{ -859,-1618,-1548,-1618,-1668},{ -529,-1288,-1218,-1288,-1338},{ -859,-1618,-1548,-1618,-1668},{ -409,-1168,-1098,-1168,-1218}} +}, +{ +/* CG.@..AU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.A..AU */ +{{ DEF,-1029, -949,-1029,-1029},{ -479,-1458,-1378,-1458,-1458},{ -309,-1288,-1208,-1288,-1288},{ -389,-1368,-1288,-1368,-1368},{ -379,-1358,-1278,-1358,-1358}}, +/* CG.C..AU */ +{{ DEF, -519, -449, -519, -669},{ -649,-1118,-1048,-1118,-1268},{ -289, -758, -688, -758, -908},{ -739,-1208,-1138,-1208,-1358},{ -379, -848, -778, -848, -998}}, +/* CG.G..AU */ +{{ DEF, -939, -939, -939, -939},{ -649,-1538,-1538,-1538,-1538},{ -289,-1178,-1178,-1178,-1178},{ -739,-1628,-1628,-1628,-1628},{ -379,-1268,-1268,-1268,-1268}}, +/* CG.U..AU */ +{{ DEF, -809, -739, -809, -859},{ -649,-1408,-1338,-1408,-1458},{ -289,-1048, -978,-1048,-1098},{ -739,-1498,-1428,-1498,-1548},{ -379,-1138,-1068,-1138,-1188}} +}, +{ +/* CG.@..UA */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.A..UA */ +{{ DEF,-1029, -949,-1029,-1029},{ -449,-1428,-1348,-1428,-1428},{ -479,-1458,-1378,-1458,-1458},{ -429,-1408,-1328,-1408,-1408},{ -329,-1308,-1228,-1308,-1308}}, +/* CG.C..UA */ +{{ DEF, -519, -449, -519, -669},{ -679,-1148,-1078,-1148,-1298},{ -559,-1028, -958,-1028,-1178},{ -729,-1198,-1128,-1198,-1348},{ -189, -658, -588, -658, -808}}, +/* CG.G..UA */ +{{ DEF, -939, -939, -939, -939},{ -939,-1828,-1828,-1828,-1828},{ -249,-1138,-1138,-1138,-1138},{ -939,-1828,-1828,-1828,-1828},{ -329,-1218,-1218,-1218,-1218}}, +/* CG.U..UA */ +{{ DEF, -809, -739, -809, -859},{ -639,-1398,-1328,-1398,-1448},{ -229, -988, -918, -988,-1038},{ -729,-1488,-1418,-1488,-1538},{ -190, -949, -879, -949, -999}} +}, +{ +/* CG.@.. @ */ +{{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.A.. @ */ +{{ -100,-1079, -999,-1079,-1079},{ -100,-1079, -999,-1079,-1079},{ -100,-1079, -999,-1079,-1079},{ -100,-1079, -999,-1079,-1079},{ -100,-1079, -999,-1079,-1079}}, +/* CG.C.. @ */ +{{ -100, -569, -499, -569, -719},{ -100, -569, -499, -569, -719},{ -100, -569, -499, -569, -719},{ -100, -569, -499, -569, -719},{ -100, -569, -499, -569, -719}}, +/* CG.G.. @ */ +{{ -100, -989, -989, -989, -989},{ -100, -989, -989, -989, -989},{ -100, -989, -989, -989, -989},{ -100, -989, -989, -989, -989},{ -100, -989, -989, -989, -989}}, +/* CG.U.. @ */ +{{ -100, -859, -789, -859, -909},{ -100, -859, -789, -859, -909},{ -100, -859, -789, -859, -909},{ -100, -859, -789, -859, -909},{ -100, -859, -789, -859, -909}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* GC.@..CG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.A..CG */ +{{ DEF, -519, -879, -559, -879},{-1079,-1548,-1908,-1588,-1908},{ -569,-1038,-1398,-1078,-1398},{ -989,-1458,-1818,-1498,-1818},{ -859,-1328,-1688,-1368,-1688}}, +/* GC.C..CG */ +{{ DEF, -719, -309, -309, -389},{ -999,-1668,-1258,-1258,-1338},{ -499,-1168, -758, -758, -838},{ -989,-1658,-1248,-1248,-1328},{ -789,-1458,-1048,-1048,-1128}}, +/* GC.G..CG */ +{{ DEF, -709, -739, -619, -739},{-1079,-1738,-1768,-1648,-1768},{ -569,-1228,-1258,-1138,-1258},{ -989,-1648,-1678,-1558,-1678},{ -859,-1518,-1548,-1428,-1548}}, +/* GC.U..CG */ +{{ DEF, -499, -499, -499, -569},{-1079,-1528,-1528,-1528,-1598},{ -719,-1168,-1168,-1168,-1238},{ -989,-1438,-1438,-1438,-1508},{ -909,-1358,-1358,-1358,-1428}} +}, +{ +/* GC.@..GC */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.A..GC */ +{{ DEF, -519, -879, -559, -879},{ -569,-1038,-1398,-1078,-1398},{ -769,-1238,-1598,-1278,-1598},{ -759,-1228,-1588,-1268,-1588},{ -549,-1018,-1378,-1058,-1378}}, +/* GC.C..GC */ +{{ DEF, -719, -309, -309, -389},{ -929,-1598,-1188,-1188,-1268},{ -359,-1028, -618, -618, -698},{ -789,-1458,-1048,-1048,-1128},{ -549,-1218, -808, -808, -888}}, +/* GC.G..GC */ +{{ DEF, -709, -739, -619, -739},{ -609,-1268,-1298,-1178,-1298},{ -359,-1018,-1048, -928,-1048},{ -669,-1328,-1358,-1238,-1358},{ -549,-1208,-1238,-1118,-1238}}, +/* GC.U..GC */ +{{ DEF, -499, -499, -499, -569},{ -929,-1378,-1378,-1378,-1448},{ -439, -888, -888, -888, -958},{ -789,-1238,-1238,-1238,-1308},{ -619,-1068,-1068,-1068,-1138}} +}, +{ +/* GC.@..GU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.A..GU */ +{{ DEF, -519, -879, -559, -879},{ -479, -948,-1308, -988,-1308},{ -309, -778,-1138, -818,-1138},{ -389, -858,-1218, -898,-1218},{ -379, -848,-1208, -888,-1208}}, +/* GC.C..GU */ +{{ DEF, -719, -309, -309, -389},{ -649,-1318, -908, -908, -988},{ -289, -958, -548, -548, -628},{ -739,-1408, -998, -998,-1078},{ -379,-1048, -638, -638, -718}}, +/* GC.G..GU */ +{{ DEF, -709, -739, -619, -739},{ -649,-1308,-1338,-1218,-1338},{ -289, -948, -978, -858, -978},{ -739,-1398,-1428,-1308,-1428},{ -379,-1038,-1068, -948,-1068}}, +/* GC.U..GU */ +{{ DEF, -499, -499, -499, -569},{ -649,-1098,-1098,-1098,-1168},{ -289, -738, -738, -738, -808},{ -739,-1188,-1188,-1188,-1258},{ -379, -828, -828, -828, -898}} +}, +{ +/* GC.@..UG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.A..UG */ +{{ DEF, -519, -879, -559, -879},{ -769,-1238,-1598,-1278,-1598},{ -529, -998,-1358,-1038,-1358},{ -709,-1178,-1538,-1218,-1538},{ -599,-1068,-1428,-1108,-1428}}, +/* GC.C..UG */ +{{ DEF, -719, -309, -309, -389},{ -839,-1508,-1098,-1098,-1178},{ -529,-1198, -788, -788, -868},{ -859,-1528,-1118,-1118,-1198},{ -489,-1158, -748, -748, -828}}, +/* GC.G..UG */ +{{ DEF, -709, -739, -619, -739},{-1009,-1668,-1698,-1578,-1698},{ -409,-1068,-1098, -978,-1098},{ -969,-1628,-1658,-1538,-1658},{ -599,-1258,-1288,-1168,-1288}}, +/* GC.U..UG */ +{{ DEF, -499, -499, -499, -569},{ -859,-1308,-1308,-1308,-1378},{ -529, -978, -978, -978,-1048},{ -859,-1308,-1308,-1308,-1378},{ -409, -858, -858, -858, -928}} +}, +{ +/* GC.@..AU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.A..AU */ +{{ DEF, -519, -879, -559, -879},{ -479, -948,-1308, -988,-1308},{ -309, -778,-1138, -818,-1138},{ -389, -858,-1218, -898,-1218},{ -379, -848,-1208, -888,-1208}}, +/* GC.C..AU */ +{{ DEF, -719, -309, -309, -389},{ -649,-1318, -908, -908, -988},{ -289, -958, -548, -548, -628},{ -739,-1408, -998, -998,-1078},{ -379,-1048, -638, -638, -718}}, +/* GC.G..AU */ +{{ DEF, -709, -739, -619, -739},{ -649,-1308,-1338,-1218,-1338},{ -289, -948, -978, -858, -978},{ -739,-1398,-1428,-1308,-1428},{ -379,-1038,-1068, -948,-1068}}, +/* GC.U..AU */ +{{ DEF, -499, -499, -499, -569},{ -649,-1098,-1098,-1098,-1168},{ -289, -738, -738, -738, -808},{ -739,-1188,-1188,-1188,-1258},{ -379, -828, -828, -828, -898}} +}, +{ +/* GC.@..UA */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.A..UA */ +{{ DEF, -519, -879, -559, -879},{ -449, -918,-1278, -958,-1278},{ -479, -948,-1308, -988,-1308},{ -429, -898,-1258, -938,-1258},{ -329, -798,-1158, -838,-1158}}, +/* GC.C..UA */ +{{ DEF, -719, -309, -309, -389},{ -679,-1348, -938, -938,-1018},{ -559,-1228, -818, -818, -898},{ -729,-1398, -988, -988,-1068},{ -189, -858, -448, -448, -528}}, +/* GC.G..UA */ +{{ DEF, -709, -739, -619, -739},{ -939,-1598,-1628,-1508,-1628},{ -249, -908, -938, -818, -938},{ -939,-1598,-1628,-1508,-1628},{ -329, -988,-1018, -898,-1018}}, +/* GC.U..UA */ +{{ DEF, -499, -499, -499, -569},{ -639,-1088,-1088,-1088,-1158},{ -229, -678, -678, -678, -748},{ -729,-1178,-1178,-1178,-1248},{ -190, -639, -639, -639, -709}} +}, +{ +/* GC.@.. @ */ +{{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.A.. @ */ +{{ -100, -569, -929, -609, -929},{ -100, -569, -929, -609, -929},{ -100, -569, -929, -609, -929},{ -100, -569, -929, -609, -929},{ -100, -569, -929, -609, -929}}, +/* GC.C.. @ */ +{{ -100, -769, -359, -359, -439},{ -100, -769, -359, -359, -439},{ -100, -769, -359, -359, -439},{ -100, -769, -359, -359, -439},{ -100, -769, -359, -359, -439}}, +/* GC.G.. @ */ +{{ -100, -759, -789, -669, -789},{ -100, -759, -789, -669, -789},{ -100, -759, -789, -669, -789},{ -100, -759, -789, -669, -789},{ -100, -759, -789, -669, -789}}, +/* GC.U.. @ */ +{{ -100, -549, -549, -549, -619},{ -100, -549, -549, -549, -619},{ -100, -549, -549, -549, -619},{ -100, -549, -549, -549, -619},{ -100, -549, -549, -549, -619}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* GU.@..CG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.A..CG */ +{{ DEF, -429, -599, -599, -599},{-1079,-1458,-1628,-1628,-1628},{ -569, -948,-1118,-1118,-1118},{ -989,-1368,-1538,-1538,-1538},{ -859,-1238,-1408,-1408,-1408}}, +/* GU.C..CG */ +{{ DEF, -259, -239, -239, -239},{ -999,-1208,-1188,-1188,-1188},{ -499, -708, -688, -688, -688},{ -989,-1198,-1178,-1178,-1178},{ -789, -998, -978, -978, -978}}, +/* GU.G..CG */ +{{ DEF, -339, -689, -689, -689},{-1079,-1368,-1718,-1718,-1718},{ -569, -858,-1208,-1208,-1208},{ -989,-1278,-1628,-1628,-1628},{ -859,-1148,-1498,-1498,-1498}}, +/* GU.U..CG */ +{{ DEF, -329, -329, -329, -329},{-1079,-1358,-1358,-1358,-1358},{ -719, -998, -998, -998, -998},{ -989,-1268,-1268,-1268,-1268},{ -909,-1188,-1188,-1188,-1188}} +}, +{ +/* GU.@..GC */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.A..GC */ +{{ DEF, -429, -599, -599, -599},{ -569, -948,-1118,-1118,-1118},{ -769,-1148,-1318,-1318,-1318},{ -759,-1138,-1308,-1308,-1308},{ -549, -928,-1098,-1098,-1098}}, +/* GU.C..GC */ +{{ DEF, -259, -239, -239, -239},{ -929,-1138,-1118,-1118,-1118},{ -359, -568, -548, -548, -548},{ -789, -998, -978, -978, -978},{ -549, -758, -738, -738, -738}}, +/* GU.G..GC */ +{{ DEF, -339, -689, -689, -689},{ -609, -898,-1248,-1248,-1248},{ -359, -648, -998, -998, -998},{ -669, -958,-1308,-1308,-1308},{ -549, -838,-1188,-1188,-1188}}, +/* GU.U..GC */ +{{ DEF, -329, -329, -329, -329},{ -929,-1208,-1208,-1208,-1208},{ -439, -718, -718, -718, -718},{ -789,-1068,-1068,-1068,-1068},{ -619, -898, -898, -898, -898}} +}, +{ +/* GU.@..GU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.A..GU */ +{{ DEF, -429, -599, -599, -599},{ -479, -858,-1028,-1028,-1028},{ -309, -688, -858, -858, -858},{ -389, -768, -938, -938, -938},{ -379, -758, -928, -928, -928}}, +/* GU.C..GU */ +{{ DEF, -259, -239, -239, -239},{ -649, -858, -838, -838, -838},{ -289, -498, -478, -478, -478},{ -739, -948, -928, -928, -928},{ -379, -588, -568, -568, -568}}, +/* GU.G..GU */ +{{ DEF, -339, -689, -689, -689},{ -649, -938,-1288,-1288,-1288},{ -289, -578, -928, -928, -928},{ -739,-1028,-1378,-1378,-1378},{ -379, -668,-1018,-1018,-1018}}, +/* GU.U..GU */ +{{ DEF, -329, -329, -329, -329},{ -649, -928, -928, -928, -928},{ -289, -568, -568, -568, -568},{ -739,-1018,-1018,-1018,-1018},{ -379, -658, -658, -658, -658}} +}, +{ +/* GU.@..UG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.A..UG */ +{{ DEF, -429, -599, -599, -599},{ -769,-1148,-1318,-1318,-1318},{ -529, -908,-1078,-1078,-1078},{ -709,-1088,-1258,-1258,-1258},{ -599, -978,-1148,-1148,-1148}}, +/* GU.C..UG */ +{{ DEF, -259, -239, -239, -239},{ -839,-1048,-1028,-1028,-1028},{ -529, -738, -718, -718, -718},{ -859,-1068,-1048,-1048,-1048},{ -489, -698, -678, -678, -678}}, +/* GU.G..UG */ +{{ DEF, -339, -689, -689, -689},{-1009,-1298,-1648,-1648,-1648},{ -409, -698,-1048,-1048,-1048},{ -969,-1258,-1608,-1608,-1608},{ -599, -888,-1238,-1238,-1238}}, +/* GU.U..UG */ +{{ DEF, -329, -329, -329, -329},{ -859,-1138,-1138,-1138,-1138},{ -529, -808, -808, -808, -808},{ -859,-1138,-1138,-1138,-1138},{ -409, -688, -688, -688, -688}} +}, +{ +/* GU.@..AU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.A..AU */ +{{ DEF, -429, -599, -599, -599},{ -479, -858,-1028,-1028,-1028},{ -309, -688, -858, -858, -858},{ -389, -768, -938, -938, -938},{ -379, -758, -928, -928, -928}}, +/* GU.C..AU */ +{{ DEF, -259, -239, -239, -239},{ -649, -858, -838, -838, -838},{ -289, -498, -478, -478, -478},{ -739, -948, -928, -928, -928},{ -379, -588, -568, -568, -568}}, +/* GU.G..AU */ +{{ DEF, -339, -689, -689, -689},{ -649, -938,-1288,-1288,-1288},{ -289, -578, -928, -928, -928},{ -739,-1028,-1378,-1378,-1378},{ -379, -668,-1018,-1018,-1018}}, +/* GU.U..AU */ +{{ DEF, -329, -329, -329, -329},{ -649, -928, -928, -928, -928},{ -289, -568, -568, -568, -568},{ -739,-1018,-1018,-1018,-1018},{ -379, -658, -658, -658, -658}} +}, +{ +/* GU.@..UA */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.A..UA */ +{{ DEF, -429, -599, -599, -599},{ -449, -828, -998, -998, -998},{ -479, -858,-1028,-1028,-1028},{ -429, -808, -978, -978, -978},{ -329, -708, -878, -878, -878}}, +/* GU.C..UA */ +{{ DEF, -259, -239, -239, -239},{ -679, -888, -868, -868, -868},{ -559, -768, -748, -748, -748},{ -729, -938, -918, -918, -918},{ -189, -398, -378, -378, -378}}, +/* GU.G..UA */ +{{ DEF, -339, -689, -689, -689},{ -939,-1228,-1578,-1578,-1578},{ -249, -538, -888, -888, -888},{ -939,-1228,-1578,-1578,-1578},{ -329, -618, -968, -968, -968}}, +/* GU.U..UA */ +{{ DEF, -329, -329, -329, -329},{ -639, -918, -918, -918, -918},{ -229, -508, -508, -508, -508},{ -729,-1008,-1008,-1008,-1008},{ -190, -469, -469, -469, -469}} +}, +{ +/* GU.@.. @ */ +{{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.A.. @ */ +{{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649}}, +/* GU.C.. @ */ +{{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289}}, +/* GU.G.. @ */ +{{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739}}, +/* GU.U.. @ */ +{{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* UG.@..CG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.A..CG */ +{{ DEF, -719, -789, -959, -809},{-1079,-1748,-1818,-1988,-1838},{ -569,-1238,-1308,-1478,-1328},{ -989,-1658,-1728,-1898,-1748},{ -859,-1528,-1598,-1768,-1618}}, +/* UG.C..CG */ +{{ DEF, -479, -479, -359, -479},{ -999,-1428,-1428,-1308,-1428},{ -499, -928, -928, -808, -928},{ -989,-1418,-1418,-1298,-1418},{ -789,-1218,-1218,-1098,-1218}}, +/* UG.G..CG */ +{{ DEF, -659, -809, -919, -809},{-1079,-1688,-1838,-1948,-1838},{ -569,-1178,-1328,-1438,-1328},{ -989,-1598,-1748,-1858,-1748},{ -859,-1468,-1618,-1728,-1618}}, +/* UG.U..CG */ +{{ DEF, -549, -439, -549, -359},{-1079,-1578,-1468,-1578,-1388},{ -719,-1218,-1108,-1218,-1028},{ -989,-1488,-1378,-1488,-1298},{ -909,-1408,-1298,-1408,-1218}} +}, +{ +/* UG.@..GC */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.A..GC */ +{{ DEF, -719, -789, -959, -809},{ -569,-1238,-1308,-1478,-1328},{ -769,-1438,-1508,-1678,-1528},{ -759,-1428,-1498,-1668,-1518},{ -549,-1218,-1288,-1458,-1308}}, +/* UG.C..GC */ +{{ DEF, -479, -479, -359, -479},{ -929,-1358,-1358,-1238,-1358},{ -359, -788, -788, -668, -788},{ -789,-1218,-1218,-1098,-1218},{ -549, -978, -978, -858, -978}}, +/* UG.G..GC */ +{{ DEF, -659, -809, -919, -809},{ -609,-1218,-1368,-1478,-1368},{ -359, -968,-1118,-1228,-1118},{ -669,-1278,-1428,-1538,-1428},{ -549,-1158,-1308,-1418,-1308}}, +/* UG.U..GC */ +{{ DEF, -549, -439, -549, -359},{ -929,-1428,-1318,-1428,-1238},{ -439, -938, -828, -938, -748},{ -789,-1288,-1178,-1288,-1098},{ -619,-1118,-1008,-1118, -928}} +}, +{ +/* UG.@..GU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.A..GU */ +{{ DEF, -719, -789, -959, -809},{ -479,-1148,-1218,-1388,-1238},{ -309, -978,-1048,-1218,-1068},{ -389,-1058,-1128,-1298,-1148},{ -379,-1048,-1118,-1288,-1138}}, +/* UG.C..GU */ +{{ DEF, -479, -479, -359, -479},{ -649,-1078,-1078, -958,-1078},{ -289, -718, -718, -598, -718},{ -739,-1168,-1168,-1048,-1168},{ -379, -808, -808, -688, -808}}, +/* UG.G..GU */ +{{ DEF, -659, -809, -919, -809},{ -649,-1258,-1408,-1518,-1408},{ -289, -898,-1048,-1158,-1048},{ -739,-1348,-1498,-1608,-1498},{ -379, -988,-1138,-1248,-1138}}, +/* UG.U..GU */ +{{ DEF, -549, -439, -549, -359},{ -649,-1148,-1038,-1148, -958},{ -289, -788, -678, -788, -598},{ -739,-1238,-1128,-1238,-1048},{ -379, -878, -768, -878, -688}} +}, +{ +/* UG.@..UG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.A..UG */ +{{ DEF, -719, -789, -959, -809},{ -769,-1438,-1508,-1678,-1528},{ -529,-1198,-1268,-1438,-1288},{ -709,-1378,-1448,-1618,-1468},{ -599,-1268,-1338,-1508,-1358}}, +/* UG.C..UG */ +{{ DEF, -479, -479, -359, -479},{ -839,-1268,-1268,-1148,-1268},{ -529, -958, -958, -838, -958},{ -859,-1288,-1288,-1168,-1288},{ -489, -918, -918, -798, -918}}, +/* UG.G..UG */ +{{ DEF, -659, -809, -919, -809},{-1009,-1618,-1768,-1878,-1768},{ -409,-1018,-1168,-1278,-1168},{ -969,-1578,-1728,-1838,-1728},{ -599,-1208,-1358,-1468,-1358}}, +/* UG.U..UG */ +{{ DEF, -549, -439, -549, -359},{ -859,-1358,-1248,-1358,-1168},{ -529,-1028, -918,-1028, -838},{ -859,-1358,-1248,-1358,-1168},{ -409, -908, -798, -908, -718}} +}, +{ +/* UG.@..AU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.A..AU */ +{{ DEF, -719, -789, -959, -809},{ -479,-1148,-1218,-1388,-1238},{ -309, -978,-1048,-1218,-1068},{ -389,-1058,-1128,-1298,-1148},{ -379,-1048,-1118,-1288,-1138}}, +/* UG.C..AU */ +{{ DEF, -479, -479, -359, -479},{ -649,-1078,-1078, -958,-1078},{ -289, -718, -718, -598, -718},{ -739,-1168,-1168,-1048,-1168},{ -379, -808, -808, -688, -808}}, +/* UG.G..AU */ +{{ DEF, -659, -809, -919, -809},{ -649,-1258,-1408,-1518,-1408},{ -289, -898,-1048,-1158,-1048},{ -739,-1348,-1498,-1608,-1498},{ -379, -988,-1138,-1248,-1138}}, +/* UG.U..AU */ +{{ DEF, -549, -439, -549, -359},{ -649,-1148,-1038,-1148, -958},{ -289, -788, -678, -788, -598},{ -739,-1238,-1128,-1238,-1048},{ -379, -878, -768, -878, -688}} +}, +{ +/* UG.@..UA */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.A..UA */ +{{ DEF, -719, -789, -959, -809},{ -449,-1118,-1188,-1358,-1208},{ -479,-1148,-1218,-1388,-1238},{ -429,-1098,-1168,-1338,-1188},{ -329, -998,-1068,-1238,-1088}}, +/* UG.C..UA */ +{{ DEF, -479, -479, -359, -479},{ -679,-1108,-1108, -988,-1108},{ -559, -988, -988, -868, -988},{ -729,-1158,-1158,-1038,-1158},{ -189, -618, -618, -498, -618}}, +/* UG.G..UA */ +{{ DEF, -659, -809, -919, -809},{ -939,-1548,-1698,-1808,-1698},{ -249, -858,-1008,-1118,-1008},{ -939,-1548,-1698,-1808,-1698},{ -329, -938,-1088,-1198,-1088}}, +/* UG.U..UA */ +{{ DEF, -549, -439, -549, -359},{ -639,-1138,-1028,-1138, -948},{ -229, -728, -618, -728, -538},{ -729,-1228,-1118,-1228,-1038},{ -190, -689, -579, -689, -499}} +}, +{ +/* UG.@.. @ */ +{{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.A.. @ */ +{{ -100, -769, -839,-1009, -859},{ -100, -769, -839,-1009, -859},{ -100, -769, -839,-1009, -859},{ -100, -769, -839,-1009, -859},{ -100, -769, -839,-1009, -859}}, +/* UG.C.. @ */ +{{ -100, -529, -529, -409, -529},{ -100, -529, -529, -409, -529},{ -100, -529, -529, -409, -529},{ -100, -529, -529, -409, -529},{ -100, -529, -529, -409, -529}}, +/* UG.G.. @ */ +{{ -100, -709, -859, -969, -859},{ -100, -709, -859, -969, -859},{ -100, -709, -859, -969, -859},{ -100, -709, -859, -969, -859},{ -100, -709, -859, -969, -859}}, +/* UG.U.. @ */ +{{ -100, -599, -489, -599, -409},{ -100, -599, -489, -599, -409},{ -100, -599, -489, -599, -409},{ -100, -599, -489, -599, -409},{ -100, -599, -489, -599, -409}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* AU.@..CG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.A..CG */ +{{ DEF, -429, -599, -599, -599},{-1079,-1458,-1628,-1628,-1628},{ -569, -948,-1118,-1118,-1118},{ -989,-1368,-1538,-1538,-1538},{ -859,-1238,-1408,-1408,-1408}}, +/* AU.C..CG */ +{{ DEF, -259, -239, -239, -239},{ -999,-1208,-1188,-1188,-1188},{ -499, -708, -688, -688, -688},{ -989,-1198,-1178,-1178,-1178},{ -789, -998, -978, -978, -978}}, +/* AU.G..CG */ +{{ DEF, -339, -689, -689, -689},{-1079,-1368,-1718,-1718,-1718},{ -569, -858,-1208,-1208,-1208},{ -989,-1278,-1628,-1628,-1628},{ -859,-1148,-1498,-1498,-1498}}, +/* AU.U..CG */ +{{ DEF, -329, -329, -329, -329},{-1079,-1358,-1358,-1358,-1358},{ -719, -998, -998, -998, -998},{ -989,-1268,-1268,-1268,-1268},{ -909,-1188,-1188,-1188,-1188}} +}, +{ +/* AU.@..GC */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.A..GC */ +{{ DEF, -429, -599, -599, -599},{ -569, -948,-1118,-1118,-1118},{ -769,-1148,-1318,-1318,-1318},{ -759,-1138,-1308,-1308,-1308},{ -549, -928,-1098,-1098,-1098}}, +/* AU.C..GC */ +{{ DEF, -259, -239, -239, -239},{ -929,-1138,-1118,-1118,-1118},{ -359, -568, -548, -548, -548},{ -789, -998, -978, -978, -978},{ -549, -758, -738, -738, -738}}, +/* AU.G..GC */ +{{ DEF, -339, -689, -689, -689},{ -609, -898,-1248,-1248,-1248},{ -359, -648, -998, -998, -998},{ -669, -958,-1308,-1308,-1308},{ -549, -838,-1188,-1188,-1188}}, +/* AU.U..GC */ +{{ DEF, -329, -329, -329, -329},{ -929,-1208,-1208,-1208,-1208},{ -439, -718, -718, -718, -718},{ -789,-1068,-1068,-1068,-1068},{ -619, -898, -898, -898, -898}} +}, +{ +/* AU.@..GU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.A..GU */ +{{ DEF, -429, -599, -599, -599},{ -479, -858,-1028,-1028,-1028},{ -309, -688, -858, -858, -858},{ -389, -768, -938, -938, -938},{ -379, -758, -928, -928, -928}}, +/* AU.C..GU */ +{{ DEF, -259, -239, -239, -239},{ -649, -858, -838, -838, -838},{ -289, -498, -478, -478, -478},{ -739, -948, -928, -928, -928},{ -379, -588, -568, -568, -568}}, +/* AU.G..GU */ +{{ DEF, -339, -689, -689, -689},{ -649, -938,-1288,-1288,-1288},{ -289, -578, -928, -928, -928},{ -739,-1028,-1378,-1378,-1378},{ -379, -668,-1018,-1018,-1018}}, +/* AU.U..GU */ +{{ DEF, -329, -329, -329, -329},{ -649, -928, -928, -928, -928},{ -289, -568, -568, -568, -568},{ -739,-1018,-1018,-1018,-1018},{ -379, -658, -658, -658, -658}} +}, +{ +/* AU.@..UG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.A..UG */ +{{ DEF, -429, -599, -599, -599},{ -769,-1148,-1318,-1318,-1318},{ -529, -908,-1078,-1078,-1078},{ -709,-1088,-1258,-1258,-1258},{ -599, -978,-1148,-1148,-1148}}, +/* AU.C..UG */ +{{ DEF, -259, -239, -239, -239},{ -839,-1048,-1028,-1028,-1028},{ -529, -738, -718, -718, -718},{ -859,-1068,-1048,-1048,-1048},{ -489, -698, -678, -678, -678}}, +/* AU.G..UG */ +{{ DEF, -339, -689, -689, -689},{-1009,-1298,-1648,-1648,-1648},{ -409, -698,-1048,-1048,-1048},{ -969,-1258,-1608,-1608,-1608},{ -599, -888,-1238,-1238,-1238}}, +/* AU.U..UG */ +{{ DEF, -329, -329, -329, -329},{ -859,-1138,-1138,-1138,-1138},{ -529, -808, -808, -808, -808},{ -859,-1138,-1138,-1138,-1138},{ -409, -688, -688, -688, -688}} +}, +{ +/* AU.@..AU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.A..AU */ +{{ DEF, -429, -599, -599, -599},{ -479, -858,-1028,-1028,-1028},{ -309, -688, -858, -858, -858},{ -389, -768, -938, -938, -938},{ -379, -758, -928, -928, -928}}, +/* AU.C..AU */ +{{ DEF, -259, -239, -239, -239},{ -649, -858, -838, -838, -838},{ -289, -498, -478, -478, -478},{ -739, -948, -928, -928, -928},{ -379, -588, -568, -568, -568}}, +/* AU.G..AU */ +{{ DEF, -339, -689, -689, -689},{ -649, -938,-1288,-1288,-1288},{ -289, -578, -928, -928, -928},{ -739,-1028,-1378,-1378,-1378},{ -379, -668,-1018,-1018,-1018}}, +/* AU.U..AU */ +{{ DEF, -329, -329, -329, -329},{ -649, -928, -928, -928, -928},{ -289, -568, -568, -568, -568},{ -739,-1018,-1018,-1018,-1018},{ -379, -658, -658, -658, -658}} +}, +{ +/* AU.@..UA */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.A..UA */ +{{ DEF, -429, -599, -599, -599},{ -449, -828, -998, -998, -998},{ -479, -858,-1028,-1028,-1028},{ -429, -808, -978, -978, -978},{ -329, -708, -878, -878, -878}}, +/* AU.C..UA */ +{{ DEF, -259, -239, -239, -239},{ -679, -888, -868, -868, -868},{ -559, -768, -748, -748, -748},{ -729, -938, -918, -918, -918},{ -189, -398, -378, -378, -378}}, +/* AU.G..UA */ +{{ DEF, -339, -689, -689, -689},{ -939,-1228,-1578,-1578,-1578},{ -249, -538, -888, -888, -888},{ -939,-1228,-1578,-1578,-1578},{ -329, -618, -968, -968, -968}}, +/* AU.U..UA */ +{{ DEF, -329, -329, -329, -329},{ -639, -918, -918, -918, -918},{ -229, -508, -508, -508, -508},{ -729,-1008,-1008,-1008,-1008},{ -190, -469, -469, -469, -469}} +}, +{ +/* AU.@.. @ */ +{{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.A.. @ */ +{{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649},{ -100, -479, -649, -649, -649}}, +/* AU.C.. @ */ +{{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289},{ -100, -309, -289, -289, -289}}, +/* AU.G.. @ */ +{{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739},{ -100, -389, -739, -739, -739}}, +/* AU.U.. @ */ +{{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379},{ -100, -379, -379, -379, -379}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* UA.@..CG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.A..CG */ +{{ DEF, -399, -629, -889, -589},{-1079,-1428,-1658,-1918,-1618},{ -569, -918,-1148,-1408,-1108},{ -989,-1338,-1568,-1828,-1528},{ -859,-1208,-1438,-1698,-1398}}, +/* UA.C..CG */ +{{ DEF, -429, -509, -199, -179},{ -999,-1378,-1458,-1148,-1128},{ -499, -878, -958, -648, -628},{ -989,-1368,-1448,-1138,-1118},{ -789,-1168,-1248, -938, -918}}, +/* UA.G..CG */ +{{ DEF, -379, -679, -889, -679},{-1079,-1408,-1708,-1918,-1708},{ -569, -898,-1198,-1408,-1198},{ -989,-1318,-1618,-1828,-1618},{ -859,-1188,-1488,-1698,-1488}}, +/* UA.U..CG */ +{{ DEF, -279, -139, -279, -140},{-1079,-1308,-1168,-1308,-1169},{ -719, -948, -808, -948, -809},{ -989,-1218,-1078,-1218,-1079},{ -909,-1138, -998,-1138, -999}} +}, +{ +/* UA.@..GC */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.A..GC */ +{{ DEF, -399, -629, -889, -589},{ -569, -918,-1148,-1408,-1108},{ -769,-1118,-1348,-1608,-1308},{ -759,-1108,-1338,-1598,-1298},{ -549, -898,-1128,-1388,-1088}}, +/* UA.C..GC */ +{{ DEF, -429, -509, -199, -179},{ -929,-1308,-1388,-1078,-1058},{ -359, -738, -818, -508, -488},{ -789,-1168,-1248, -938, -918},{ -549, -928,-1008, -698, -678}}, +/* UA.G..GC */ +{{ DEF, -379, -679, -889, -679},{ -609, -938,-1238,-1448,-1238},{ -359, -688, -988,-1198, -988},{ -669, -998,-1298,-1508,-1298},{ -549, -878,-1178,-1388,-1178}}, +/* UA.U..GC */ +{{ DEF, -279, -139, -279, -140},{ -929,-1158,-1018,-1158,-1019},{ -439, -668, -528, -668, -529},{ -789,-1018, -878,-1018, -879},{ -619, -848, -708, -848, -709}} +}, +{ +/* UA.@..GU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.A..GU */ +{{ DEF, -399, -629, -889, -589},{ -479, -828,-1058,-1318,-1018},{ -309, -658, -888,-1148, -848},{ -389, -738, -968,-1228, -928},{ -379, -728, -958,-1218, -918}}, +/* UA.C..GU */ +{{ DEF, -429, -509, -199, -179},{ -649,-1028,-1108, -798, -778},{ -289, -668, -748, -438, -418},{ -739,-1118,-1198, -888, -868},{ -379, -758, -838, -528, -508}}, +/* UA.G..GU */ +{{ DEF, -379, -679, -889, -679},{ -649, -978,-1278,-1488,-1278},{ -289, -618, -918,-1128, -918},{ -739,-1068,-1368,-1578,-1368},{ -379, -708,-1008,-1218,-1008}}, +/* UA.U..GU */ +{{ DEF, -279, -139, -279, -140},{ -649, -878, -738, -878, -739},{ -289, -518, -378, -518, -379},{ -739, -968, -828, -968, -829},{ -379, -608, -468, -608, -469}} +}, +{ +/* UA.@..UG */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.A..UG */ +{{ DEF, -399, -629, -889, -589},{ -769,-1118,-1348,-1608,-1308},{ -529, -878,-1108,-1368,-1068},{ -709,-1058,-1288,-1548,-1248},{ -599, -948,-1178,-1438,-1138}}, +/* UA.C..UG */ +{{ DEF, -429, -509, -199, -179},{ -839,-1218,-1298, -988, -968},{ -529, -908, -988, -678, -658},{ -859,-1238,-1318,-1008, -988},{ -489, -868, -948, -638, -618}}, +/* UA.G..UG */ +{{ DEF, -379, -679, -889, -679},{-1009,-1338,-1638,-1848,-1638},{ -409, -738,-1038,-1248,-1038},{ -969,-1298,-1598,-1808,-1598},{ -599, -928,-1228,-1438,-1228}}, +/* UA.U..UG */ +{{ DEF, -279, -139, -279, -140},{ -859,-1088, -948,-1088, -949},{ -529, -758, -618, -758, -619},{ -859,-1088, -948,-1088, -949},{ -409, -638, -498, -638, -499}} +}, +{ +/* UA.@..AU */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.A..AU */ +{{ DEF, -399, -629, -889, -589},{ -479, -828,-1058,-1318,-1018},{ -309, -658, -888,-1148, -848},{ -389, -738, -968,-1228, -928},{ -379, -728, -958,-1218, -918}}, +/* UA.C..AU */ +{{ DEF, -429, -509, -199, -179},{ -649,-1028,-1108, -798, -778},{ -289, -668, -748, -438, -418},{ -739,-1118,-1198, -888, -868},{ -379, -758, -838, -528, -508}}, +/* UA.G..AU */ +{{ DEF, -379, -679, -889, -679},{ -649, -978,-1278,-1488,-1278},{ -289, -618, -918,-1128, -918},{ -739,-1068,-1368,-1578,-1368},{ -379, -708,-1008,-1218,-1008}}, +/* UA.U..AU */ +{{ DEF, -279, -139, -279, -140},{ -649, -878, -738, -878, -739},{ -289, -518, -378, -518, -379},{ -739, -968, -828, -968, -829},{ -379, -608, -468, -608, -469}} +}, +{ +/* UA.@..UA */ +{{ 0, 0, 0, 0, 0},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.A..UA */ +{{ DEF, -399, -629, -889, -589},{ -449, -798,-1028,-1288, -988},{ -479, -828,-1058,-1318,-1018},{ -429, -778,-1008,-1268, -968},{ -329, -678, -908,-1168, -868}}, +/* UA.C..UA */ +{{ DEF, -429, -509, -199, -179},{ -679,-1058,-1138, -828, -808},{ -559, -938,-1018, -708, -688},{ -729,-1108,-1188, -878, -858},{ -189, -568, -648, -338, -318}}, +/* UA.G..UA */ +{{ DEF, -379, -679, -889, -679},{ -939,-1268,-1568,-1778,-1568},{ -249, -578, -878,-1088, -878},{ -939,-1268,-1568,-1778,-1568},{ -329, -658, -958,-1168, -958}}, +/* UA.U..UA */ +{{ DEF, -279, -139, -279, -140},{ -639, -868, -728, -868, -729},{ -229, -458, -318, -458, -319},{ -729, -958, -818, -958, -819},{ -190, -419, -279, -419, -280}} +}, +{ +/* UA.@.. @ */ +{{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF},{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.A.. @ */ +{{ -100, -449, -679, -939, -639},{ -100, -449, -679, -939, -639},{ -100, -449, -679, -939, -639},{ -100, -449, -679, -939, -639},{ -100, -449, -679, -939, -639}}, +/* UA.C.. @ */ +{{ -100, -479, -559, -249, -229},{ -100, -479, -559, -249, -229},{ -100, -479, -559, -249, -229},{ -100, -479, -559, -249, -229},{ -100, -479, -559, -249, -229}}, +/* UA.G.. @ */ +{{ -100, -429, -729, -939, -729},{ -100, -429, -729, -939, -729},{ -100, -429, -729, -939, -729},{ -100, -429, -729, -939, -729},{ -100, -429, -729, -939, -729}}, +/* UA.U.. @ */ +{{ -100, -329, -189, -329, -190},{ -100, -329, -189, -329, -190},{ -100, -329, -189, -329, -190},{ -100, -329, -189, -329, -190},{ -100, -329, -189, -329, -190}} +} +}, +{ /* noPair */ {{{0}}}, +{ +/* @.@..CG */ +{{ DEF, DEF, DEF, DEF, DEF},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.A..CG */ +{{ DEF, DEF, DEF, DEF, DEF},{-1079,-1079,-1079,-1079,-1079},{ -569, -569, -569, -569, -569},{ -989, -989, -989, -989, -989},{ -859, -859, -859, -859, -859}}, +/* @.C..CG */ +{{ DEF, DEF, DEF, DEF, DEF},{ -999, -999, -999, -999, -999},{ -499, -499, -499, -499, -499},{ -989, -989, -989, -989, -989},{ -789, -789, -789, -789, -789}}, +/* @.G..CG */ +{{ DEF, DEF, DEF, DEF, DEF},{-1079,-1079,-1079,-1079,-1079},{ -569, -569, -569, -569, -569},{ -989, -989, -989, -989, -989},{ -859, -859, -859, -859, -859}}, +/* @.U..CG */ +{{ DEF, DEF, DEF, DEF, DEF},{-1079,-1079,-1079,-1079,-1079},{ -719, -719, -719, -719, -719},{ -989, -989, -989, -989, -989},{ -909, -909, -909, -909, -909}} +}, +{ +/* @.@..GC */ +{{ DEF, DEF, DEF, DEF, DEF},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.A..GC */ +{{ DEF, DEF, DEF, DEF, DEF},{ -569, -569, -569, -569, -569},{ -769, -769, -769, -769, -769},{ -759, -759, -759, -759, -759},{ -549, -549, -549, -549, -549}}, +/* @.C..GC */ +{{ DEF, DEF, DEF, DEF, DEF},{ -929, -929, -929, -929, -929},{ -359, -359, -359, -359, -359},{ -789, -789, -789, -789, -789},{ -549, -549, -549, -549, -549}}, +/* @.G..GC */ +{{ DEF, DEF, DEF, DEF, DEF},{ -609, -609, -609, -609, -609},{ -359, -359, -359, -359, -359},{ -669, -669, -669, -669, -669},{ -549, -549, -549, -549, -549}}, +/* @.U..GC */ +{{ DEF, DEF, DEF, DEF, DEF},{ -929, -929, -929, -929, -929},{ -439, -439, -439, -439, -439},{ -789, -789, -789, -789, -789},{ -619, -619, -619, -619, -619}} +}, +{ +/* @.@..GU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.A..GU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -479, -479, -479, -479, -479},{ -309, -309, -309, -309, -309},{ -389, -389, -389, -389, -389},{ -379, -379, -379, -379, -379}}, +/* @.C..GU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -649, -649, -649, -649, -649},{ -289, -289, -289, -289, -289},{ -739, -739, -739, -739, -739},{ -379, -379, -379, -379, -379}}, +/* @.G..GU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -649, -649, -649, -649, -649},{ -289, -289, -289, -289, -289},{ -739, -739, -739, -739, -739},{ -379, -379, -379, -379, -379}}, +/* @.U..GU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -649, -649, -649, -649, -649},{ -289, -289, -289, -289, -289},{ -739, -739, -739, -739, -739},{ -379, -379, -379, -379, -379}} +}, +{ +/* @.@..UG */ +{{ DEF, DEF, DEF, DEF, DEF},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.A..UG */ +{{ DEF, DEF, DEF, DEF, DEF},{ -769, -769, -769, -769, -769},{ -529, -529, -529, -529, -529},{ -709, -709, -709, -709, -709},{ -599, -599, -599, -599, -599}}, +/* @.C..UG */ +{{ DEF, DEF, DEF, DEF, DEF},{ -839, -839, -839, -839, -839},{ -529, -529, -529, -529, -529},{ -859, -859, -859, -859, -859},{ -489, -489, -489, -489, -489}}, +/* @.G..UG */ +{{ DEF, DEF, DEF, DEF, DEF},{-1009,-1009,-1009,-1009,-1009},{ -409, -409, -409, -409, -409},{ -969, -969, -969, -969, -969},{ -599, -599, -599, -599, -599}}, +/* @.U..UG */ +{{ DEF, DEF, DEF, DEF, DEF},{ -859, -859, -859, -859, -859},{ -529, -529, -529, -529, -529},{ -859, -859, -859, -859, -859},{ -409, -409, -409, -409, -409}} +}, +{ +/* @.@..AU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.A..AU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -479, -479, -479, -479, -479},{ -309, -309, -309, -309, -309},{ -389, -389, -389, -389, -389},{ -379, -379, -379, -379, -379}}, +/* @.C..AU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -649, -649, -649, -649, -649},{ -289, -289, -289, -289, -289},{ -739, -739, -739, -739, -739},{ -379, -379, -379, -379, -379}}, +/* @.G..AU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -649, -649, -649, -649, -649},{ -289, -289, -289, -289, -289},{ -739, -739, -739, -739, -739},{ -379, -379, -379, -379, -379}}, +/* @.U..AU */ +{{ DEF, DEF, DEF, DEF, DEF},{ -649, -649, -649, -649, -649},{ -289, -289, -289, -289, -289},{ -739, -739, -739, -739, -739},{ -379, -379, -379, -379, -379}} +}, +{ +/* @.@..UA */ +{{ DEF, DEF, DEF, DEF, DEF},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.A..UA */ +{{ DEF, DEF, DEF, DEF, DEF},{ -449, -449, -449, -449, -449},{ -479, -479, -479, -479, -479},{ -429, -429, -429, -429, -429},{ -329, -329, -329, -329, -329}}, +/* @.C..UA */ +{{ DEF, DEF, DEF, DEF, DEF},{ -679, -679, -679, -679, -679},{ -559, -559, -559, -559, -559},{ -729, -729, -729, -729, -729},{ -189, -189, -189, -189, -189}}, +/* @.G..UA */ +{{ DEF, DEF, DEF, DEF, DEF},{ -939, -939, -939, -939, -939},{ -249, -249, -249, -249, -249},{ -939, -939, -939, -939, -939},{ -329, -329, -329, -329, -329}}, +/* @.U..UA */ +{{ DEF, DEF, DEF, DEF, DEF},{ -639, -639, -639, -639, -639},{ -229, -229, -229, -229, -229},{ -729, -729, -729, -729, -729},{ -190, -190, -190, -190, -190}} +}, +{ +/* @.@.. @ */ +{{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.A.. @ */ +{{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.C.. @ */ +{{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.G.. @ */ +{{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}}, +/* @.U.. @ */ +{{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100},{ -100, -100, -100, -100, -100}} +} +} +}; + +PRIVATE int int22_37_184[NBPAIRS+1][NBPAIRS+1][5][5][5][5] = { +/* noPair */ {{{{{0}}}}}, +{ /* noPair */ {{{{0}}}}, +/* CG....CG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 160, 30, 200},{ 340, 120, 150, 20, 200},{ 340, 30, 60, -70, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 200, 60, 200},{ 340, 210, 180, 150, 200},{ 340, 200, 200, 200, 200},{ 340, 190, 170, 130, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 30, 60, -70, 200},{ 340, 200, 200, 200, 200},{ 340, 100, 140, 0, 200},{ 340, -40, -110, -60, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 190, 170, 130, 200},{ 340, 110, 40, 90, 200},{ 340, 140, 80, 130, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 120, 210, 200, 190},{ 340, 110, 140, 200, 120},{ 340, 20, 150, 200, 130},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 180, 200, 170},{ 340, 140, 170, 200, 150},{ 340, 200, 200, 200, 200},{ 340, 120, 150, 200, 140}}, +{{ 340, 340, 340, 340, 340},{ 340, 20, 150, 200, 130},{ 340, 200, 200, 200, 200},{ 340, 90, 180, 200, 170},{ 340, -150, -20, 200, -40}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 120, 150, 200, 140},{ 340, 0, 130, 200, 110},{ 340, 30, 60, 200, 50}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 30, 200, 100, 110},{ 340, 20, 200, 90, 0},{ 340, -70, 200, 0, 90},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 200, 140, 40},{ 340, 150, 200, 180, 130},{ 340, 200, 200, 200, 200},{ 340, 130, 200, 170, 110}}, +{{ 340, 340, 340, 340, 340},{ 340, -70, 200, 0, 90},{ 340, 200, 200, 200, 200},{ 340, 0, 200, 80, 90},{ 340, -60, 200, -70, -260}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 130, 200, 170, 110},{ 340, 90, 200, 90, -110},{ 340, 130, 200, 120, 110}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 190, -40, 140},{ 340, 200, 120, -150, 30},{ 340, 200, 130, -60, 130},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 170, -110, 80},{ 340, 200, 150, -20, 60},{ 340, 200, 200, 200, 200},{ 340, 200, 140, -40, 50}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 130, -60, 130},{ 340, 200, 200, 200, 200},{ 340, 200, 170, -70, 120},{ 340, 200, -40, -420, -50}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 140, -40, 50},{ 340, 200, 110, -260, 110},{ 340, 200, 50, -50, -40}} +} +}, +/* CG....GC */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 60, 0, 200},{ 340, 110, 150, -70, 200},{ 340, -30, 10, -160, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 110, -100, 200},{ 340, 170, 150, -60, 200},{ 340, 200, 200, 200, 200},{ 340, 70, 50, 20, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 40, 50, -70, 200},{ 340, 200, 200, 200, 200},{ 340, 100, 140, 0, 200},{ 340, 10, -70, -80, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 180, 150, 120, 200},{ 340, -50, -60, -60, 200},{ 340, 150, 0, 90, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 220, 200, 200},{ 340, 100, 130, 200, 120},{ 340, -70, 70, 200, 40},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 190, 200, 110},{ 340, 100, 130, 200, 120},{ 340, 200, 200, 200, 200},{ 340, 0, 30, 200, 170}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 70, 200, 100},{ 340, 200, 200, 200, 200},{ 340, 90, 180, 200, 170},{ 340, -190, -30, 200, -70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 110, 140, 200, 120},{ 340, -150, -20, 200, -30},{ 340, -20, -10, 200, 20}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, -20, 200, 110, 90},{ 340, -40, 200, 90, 0},{ 340, -170, 200, -90, 30},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 200, 80, -10},{ 340, 110, 200, 150, 100},{ 340, 200, 200, 200, 200},{ 340, 20, 200, 50, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, -50, 200, -20, 60},{ 340, 200, 200, 200, 200},{ 340, 0, 200, 80, 90},{ 340, -90, 200, -100, -300}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 120, 200, 150, 100},{ 340, -130, 200, -60, -240},{ 340, 90, 200, 110, 60}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, -10, 140},{ 340, 200, 120, -160, 30},{ 340, 200, 40, -160, 50},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 110, -160, 30},{ 340, 200, 120, -60, 30},{ 340, 200, 200, 200, 200},{ 340, 200, 20, -160, 10}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 50, -60, 140},{ 340, 200, 200, 200, 200},{ 340, 200, 170, -70, 120},{ 340, 200, -70, -440, -100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 120, -50, 30},{ 340, 200, -10, -410, 10},{ 340, 200, 40, -100, 60}} +} +}, +/* CG....GU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 100, 200},{ 340, 180, 210, 80, 200},{ 340, 80, 110, -20, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 220, 90, 200},{ 340, 230, 210, 170, 200},{ 340, 200, 200, 200, 200},{ 340, 230, 210, 170, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 110, -20, 200},{ 340, 200, 200, 200, 200},{ 340, 130, 170, 30, 200},{ 340, 60, 0, 40, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 230, 210, 170, 200},{ 340, 160, 90, 140, 200},{ 340, 190, 130, 180, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 280, 200, 270},{ 340, 170, 200, 200, 180},{ 340, 70, 200, 200, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 210, 200, 190},{ 340, 160, 190, 200, 180},{ 340, 200, 200, 200, 200},{ 340, 160, 190, 200, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 200, 200, 180},{ 340, 200, 200, 200, 200},{ 340, 120, 210, 200, 200},{ 340, -50, 80, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 190, 200, 180},{ 340, 50, 180, 200, 160},{ 340, 80, 110, 200, 100}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 180, 180},{ 340, 80, 200, 150, 60},{ 340, -20, 200, 50, 140},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 200, 160, 70},{ 340, 170, 200, 210, 150},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 210, 150}}, +{{ 340, 340, 340, 340, 340},{ 340, -20, 200, 50, 140},{ 340, 200, 200, 200, 200},{ 340, 30, 200, 110, 110},{ 340, 40, 200, 40, -160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 210, 150},{ 340, 140, 200, 130, -60},{ 340, 180, 200, 170, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 30, 220},{ 340, 200, 180, -90, 90},{ 340, 200, 180, -10, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 190, -80, 100},{ 340, 200, 180, 0, 90},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 0, 90}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 180, -10, 180},{ 340, 200, 200, 200, 200},{ 340, 200, 200, -40, 150},{ 340, 200, 70, -310, 60}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 0, 90},{ 340, 200, 160, -210, 160},{ 340, 200, 100, 0, 10}} +} +}, +/* CG....UG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 100, 200},{ 340, 160, 190, 60, 200},{ 340, 100, 130, 0, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 100, 200},{ 340, 260, 240, 200, 200},{ 340, 200, 200, 200, 200},{ 340, 260, 240, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 130, 0, 200},{ 340, 200, 200, 200, 200},{ 340, 140, 170, 40, 200},{ 340, 20, -40, 0, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 230, 210, 170, 200},{ 340, 150, 80, 130, 200},{ 340, 220, 150, 200, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 280, 200, 270},{ 340, 150, 180, 200, 160},{ 340, 90, 220, 200, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 220, 200, 210},{ 340, 190, 220, 200, 210},{ 340, 200, 200, 200, 200},{ 340, 190, 220, 200, 210}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 220, 200, 200},{ 340, 200, 200, 200, 200},{ 340, 130, 220, 200, 200},{ 340, -90, 40, 200, 30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 190, 200, 180},{ 340, 40, 170, 200, 150},{ 340, 110, 140, 200, 120}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 180, 180},{ 340, 60, 200, 130, 40},{ 340, 0, 200, 70, 160},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 180, 80},{ 340, 200, 200, 240, 180},{ 340, 200, 200, 200, 200},{ 340, 200, 200, 240, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 0, 200, 70, 160},{ 340, 200, 200, 200, 200},{ 340, 40, 200, 110, 120},{ 340, 0, 200, 0, -200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 210, 150},{ 340, 130, 200, 120, -70},{ 340, 200, 200, 190, 180}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 30, 220},{ 340, 200, 160, -110, 70},{ 340, 200, 200, 10, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 210, -70, 120},{ 340, 200, 210, 30, 120},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 30, 120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 10, 190},{ 340, 200, 200, 200, 200},{ 340, 200, 200, -30, 150},{ 340, 200, 30, -350, 20}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 0, 90},{ 340, 200, 150, -220, 150},{ 340, 200, 120, 30, 30}} +} +}, +/* CG....AU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 100, 200},{ 340, 180, 210, 80, 200},{ 340, 80, 110, -20, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 220, 90, 200},{ 340, 230, 210, 170, 200},{ 340, 200, 200, 200, 200},{ 340, 230, 210, 170, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 110, -20, 200},{ 340, 200, 200, 200, 200},{ 340, 130, 170, 30, 200},{ 340, 60, 0, 40, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 230, 210, 170, 200},{ 340, 160, 90, 140, 200},{ 340, 190, 130, 180, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 280, 200, 270},{ 340, 170, 200, 200, 180},{ 340, 70, 200, 200, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 210, 200, 190},{ 340, 160, 190, 200, 180},{ 340, 200, 200, 200, 200},{ 340, 160, 190, 200, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 200, 200, 180},{ 340, 200, 200, 200, 200},{ 340, 120, 210, 200, 200},{ 340, -50, 80, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 190, 200, 180},{ 340, 50, 180, 200, 160},{ 340, 80, 110, 200, 100}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 180, 180},{ 340, 80, 200, 150, 60},{ 340, -20, 200, 50, 140},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 200, 160, 70},{ 340, 170, 200, 210, 150},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 210, 150}}, +{{ 340, 340, 340, 340, 340},{ 340, -20, 200, 50, 140},{ 340, 200, 200, 200, 200},{ 340, 30, 200, 110, 110},{ 340, 40, 200, 40, -160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 210, 150},{ 340, 140, 200, 130, -60},{ 340, 180, 200, 170, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 30, 220},{ 340, 200, 180, -90, 90},{ 340, 200, 180, -10, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 190, -80, 100},{ 340, 200, 180, 0, 90},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 0, 90}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 180, -10, 180},{ 340, 200, 200, 200, 200},{ 340, 200, 200, -40, 150},{ 340, 200, 70, -310, 60}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 0, 90},{ 340, 200, 160, -210, 160},{ 340, 200, 100, 0, 10}} +} +}, +/* CG....UA */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 100, 200},{ 340, 160, 190, 60, 200},{ 340, 100, 130, 0, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 100, 200},{ 340, 260, 240, 200, 200},{ 340, 200, 200, 200, 200},{ 340, 260, 240, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 130, 0, 200},{ 340, 200, 200, 200, 200},{ 340, 140, 170, 40, 200},{ 340, 20, -40, 0, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 230, 210, 170, 200},{ 340, 150, 80, 130, 200},{ 340, 220, 150, 200, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 280, 200, 270},{ 340, 150, 180, 200, 160},{ 340, 90, 220, 200, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 220, 200, 210},{ 340, 190, 220, 200, 210},{ 340, 200, 200, 200, 200},{ 340, 190, 220, 200, 210}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 220, 200, 200},{ 340, 200, 200, 200, 200},{ 340, 130, 220, 200, 200},{ 340, -90, 40, 200, 30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 190, 200, 180},{ 340, 40, 170, 200, 150},{ 340, 110, 140, 200, 120}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 180, 180},{ 340, 60, 200, 130, 40},{ 340, 0, 200, 70, 160},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 180, 80},{ 340, 200, 200, 240, 180},{ 340, 200, 200, 200, 200},{ 340, 200, 200, 240, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 0, 200, 70, 160},{ 340, 200, 200, 200, 200},{ 340, 40, 200, 110, 120},{ 340, 0, 200, 0, -200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 210, 150},{ 340, 130, 200, 120, -70},{ 340, 200, 200, 190, 180}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 30, 220},{ 340, 200, 160, -110, 70},{ 340, 200, 200, 10, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 210, -70, 120},{ 340, 200, 210, 30, 120},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 30, 120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 10, 190},{ 340, 200, 200, 200, 200},{ 340, 200, 200, -30, 150},{ 340, 200, 30, -350, 20}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 0, 90},{ 340, 200, 150, -220, 150},{ 340, 200, 120, 30, 30}} +} +}, +/* CG....?? */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +} +}, +{ /* noPair */ {{{{0}}}}, +/* GC....CG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 110, 40, 200},{ 340, 130, 100, 70, 200},{ 340, -20, 70, -50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 110, 50, 200},{ 340, 220, 190, 70, 200},{ 340, 200, 200, 200, 200},{ 340, 200, 110, 50, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 0, -100, -70, 200},{ 340, 200, 200, 200, 200},{ 340, 110, 80, -20, 200},{ 340, -10, -160, -60, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 110, 100, 200},{ 340, 90, -10, 60, 200},{ 340, 140, 30, 140, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 170, 200, 180},{ 340, 100, 100, 200, 110},{ 340, -40, 110, 200, 120},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 150, 200, 150},{ 340, 130, 130, 200, 140},{ 340, 200, 200, 200, 200},{ 340, 120, 120, 200, 120}}, +{{ 340, 340, 340, 340, 340},{ 340, -70, -60, 200, 120},{ 340, 200, 200, 200, 200},{ 340, 90, 150, 200, 150},{ 340, -160, -60, 200, -50}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 120, 120, 200, 120},{ 340, 0, 100, 200, 100},{ 340, 30, 30, 200, 30}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, -30, 200, 100, -50},{ 340, -70, 200, 90, -150},{ 340, -170, 200, 0, -130},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, 200, 140, -60},{ 340, 70, 200, 180, -20},{ 340, 200, 200, 200, 200},{ 340, 40, 200, 170, -10}}, +{{ 340, 340, 340, 340, 340},{ 340, -160, 200, 0, -60},{ 340, 200, 200, 200, 200},{ 340, -90, 200, 80, -60},{ 340, -160, 200, -70, -410}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 40, 200, 170, -30},{ 340, 30, 200, 90, -240},{ 340, 50, 200, 120, 10}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 70, 10, 150},{ 340, 200, 0, -190, -20},{ 340, 200, 20, -90, 90},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 50, -70, 0},{ 340, 200, 30, -30, -10},{ 340, 200, 200, 200, 200},{ 340, 200, 20, -70, 40}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 20, -80, 90},{ 340, 200, 200, 200, 200},{ 340, 200, 50, -100, 110},{ 340, 200, -160, -440, -100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 170, -70, 20},{ 340, 200, 0, -300, 60},{ 340, 200, 10, -100, 60}} +} +}, +/* GC....GC */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 120, 10, 200},{ 340, 120, 90, -10, 200},{ 340, -50, -80, -190, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 120, 90, -20, 200},{ 340, 180, 90, 90, 200},{ 340, 200, 200, 200, 200},{ 340, 80, 0, -10, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, -20, -130, 200},{ 340, 200, 200, 200, 200},{ 340, 110, 80, -20, 200},{ 340, -70, -200, -130, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 190, 100, 90, 200},{ 340, -30, -160, -90, 200},{ 340, 150, 20, 90, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 120, 180, 200, 190},{ 340, 100, 100, 200, 100},{ 340, -80, 20, 200, 30},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 90, 200, 100},{ 340, 100, 100, 200, 100},{ 340, 200, 200, 200, 200},{ 340, 0, 0, 200, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, -10, 90, 200, 90},{ 340, 200, 200, 200, 200},{ 340, 90, 150, 200, 150},{ 340, -190, -90, 200, -90}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 100, 100, 200, 110},{ 340, -150, -50, 200, -50},{ 340, 20, 20, 200, 30}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, -50, 200, 110, -30},{ 340, -80, 200, 90, -150},{ 340, -260, 200, -90, -150},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, -80, 200, 80, -160},{ 340, 20, 200, 150, -50},{ 340, 200, 200, 200, 200},{ 340, -80, 200, 50, -150}}, +{{ 340, 340, 340, 340, 340},{ 340, -190, 200, -20, -90},{ 340, 200, 200, 200, 200},{ 340, -90, 200, 80, -60},{ 340, -190, 200, -100, -450}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 30, 200, 150, -50},{ 340, -150, 200, -60, -410},{ 340, 30, 200, 110, -50}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 80, -70, 150},{ 340, 200, 0, -190, 20},{ 340, 200, -80, -190, 30},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 0, -200, 20},{ 340, 200, 0, -90, 20},{ 340, 200, 200, 200, 200},{ 340, 200, -100, -190, -70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, -10, -130, 90},{ 340, 200, 200, 200, 200},{ 340, 200, 50, -100, 110},{ 340, 200, -190, -490, -90}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 0, -90, 30},{ 340, 200, -150, -450, -50},{ 340, 200, -70, -90, -50}} +} +}, +/* GC....GU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 180, 70, 200},{ 340, 190, 160, 50, 200},{ 340, 90, 60, -50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 170, 60, 200},{ 340, 240, 150, 140, 200},{ 340, 200, 200, 200, 200},{ 340, 240, 150, 140, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 60, -50, 200},{ 340, 200, 200, 200, 200},{ 340, 140, 110, 0, 200},{ 340, 70, -60, 10, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 150, 140, 200},{ 340, 170, 40, 110, 200},{ 340, 200, 70, 150, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 250, 200, 250},{ 340, 160, 160, 200, 170},{ 340, 60, 160, 200, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 170, 200, 180},{ 340, 160, 160, 200, 160},{ 340, 200, 200, 200, 200},{ 340, 160, 160, 200, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 160, 200, 170},{ 340, 200, 200, 200, 200},{ 340, 120, 180, 200, 180},{ 340, -50, 50, 200, 50}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 160, 200, 160},{ 340, 40, 140, 200, 150},{ 340, 80, 80, 200, 80}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, 200, 180, 40},{ 340, -10, 200, 150, -90},{ 340, -110, 200, 50, -10},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 0, 200, 160, -80},{ 340, 80, 200, 210, 10},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 210, 10}}, +{{ 340, 340, 340, 340, 340},{ 340, -110, 200, 50, -10},{ 340, 200, 200, 200, 200},{ 340, -60, 200, 110, -30},{ 340, -50, 200, 40, -310}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 210, 10},{ 340, 50, 200, 130, -210},{ 340, 80, 200, 170, 10}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 150, 0, 210},{ 340, 200, 60, -130, 90},{ 340, 200, 70, -50, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 70, -120, 100},{ 340, 200, 60, -30, 80},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -30, 80}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 70, -50, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 80, -70, 140},{ 340, 200, -50, -350, 50}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -30, 80},{ 340, 200, 50, -250, 150},{ 340, 200, -20, -30, 0}} +} +}, +/* GC....UG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 180, 70, 200},{ 340, 170, 140, 30, 200},{ 340, 110, 80, -30, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 180, 70, 200},{ 340, 270, 180, 170, 200},{ 340, 200, 200, 200, 200},{ 340, 270, 180, 170, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 80, -30, 200},{ 340, 200, 200, 200, 200},{ 340, 150, 120, 10, 200},{ 340, 30, -100, -30, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 150, 140, 200},{ 340, 160, 30, 100, 200},{ 340, 230, 100, 170, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 250, 200, 250},{ 340, 140, 140, 200, 150},{ 340, 80, 180, 200, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 190, 200, 190},{ 340, 190, 190, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 190, 190, 200, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 180, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 120, 180, 200, 190},{ 340, -90, 10, 200, 10}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 160, 200, 160},{ 340, 30, 130, 200, 140},{ 340, 100, 100, 200, 110}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, 200, 180, 40},{ 340, -30, 200, 130, -110},{ 340, -90, 200, 70, 10},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, 200, 180, -60},{ 340, 110, 200, 240, 40},{ 340, 200, 200, 200, 200},{ 340, 110, 200, 240, 40}}, +{{ 340, 340, 340, 340, 340},{ 340, -90, 200, 70, 10},{ 340, 200, 200, 200, 200},{ 340, -50, 200, 110, -30},{ 340, -90, 200, 0, -350}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 210, 10},{ 340, 40, 200, 120, -220},{ 340, 110, 200, 190, 30}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 150, 0, 210},{ 340, 200, 40, -150, 70},{ 340, 200, 90, -30, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 90, -100, 110},{ 340, 200, 90, 0, 110},{ 340, 200, 200, 200, 200},{ 340, 200, 90, 0, 110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 90, -30, 190},{ 340, 200, 200, 200, 200},{ 340, 200, 80, -70, 150},{ 340, 200, -90, -390, 10}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -30, 80},{ 340, 200, 40, -260, 140},{ 340, 200, 0, -10, 30}} +} +}, +/* GC....AU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 180, 70, 200},{ 340, 190, 160, 50, 200},{ 340, 90, 60, -50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 170, 60, 200},{ 340, 240, 150, 140, 200},{ 340, 200, 200, 200, 200},{ 340, 240, 150, 140, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 60, -50, 200},{ 340, 200, 200, 200, 200},{ 340, 140, 110, 0, 200},{ 340, 70, -60, 10, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 150, 140, 200},{ 340, 170, 40, 110, 200},{ 340, 200, 70, 150, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 250, 200, 250},{ 340, 160, 160, 200, 170},{ 340, 60, 160, 200, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 170, 200, 180},{ 340, 160, 160, 200, 160},{ 340, 200, 200, 200, 200},{ 340, 160, 160, 200, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 160, 200, 170},{ 340, 200, 200, 200, 200},{ 340, 120, 180, 200, 180},{ 340, -50, 50, 200, 50}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 160, 200, 160},{ 340, 40, 140, 200, 150},{ 340, 80, 80, 200, 80}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, 200, 180, 40},{ 340, -10, 200, 150, -90},{ 340, -110, 200, 50, -10},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 0, 200, 160, -80},{ 340, 80, 200, 210, 10},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 210, 10}}, +{{ 340, 340, 340, 340, 340},{ 340, -110, 200, 50, -10},{ 340, 200, 200, 200, 200},{ 340, -60, 200, 110, -30},{ 340, -50, 200, 40, -310}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 210, 10},{ 340, 50, 200, 130, -210},{ 340, 80, 200, 170, 10}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 150, 0, 210},{ 340, 200, 60, -130, 90},{ 340, 200, 70, -50, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 70, -120, 100},{ 340, 200, 60, -30, 80},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -30, 80}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 70, -50, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 80, -70, 140},{ 340, 200, -50, -350, 50}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -30, 80},{ 340, 200, 50, -250, 150},{ 340, 200, -20, -30, 0}} +} +}, +/* GC....UA */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 180, 70, 200},{ 340, 170, 140, 30, 200},{ 340, 110, 80, -30, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 180, 70, 200},{ 340, 270, 180, 170, 200},{ 340, 200, 200, 200, 200},{ 340, 270, 180, 170, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 80, -30, 200},{ 340, 200, 200, 200, 200},{ 340, 150, 120, 10, 200},{ 340, 30, -100, -30, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 150, 140, 200},{ 340, 160, 30, 100, 200},{ 340, 230, 100, 170, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 250, 200, 250},{ 340, 140, 140, 200, 150},{ 340, 80, 180, 200, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 190, 200, 190},{ 340, 190, 190, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 190, 190, 200, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 180, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 120, 180, 200, 190},{ 340, -90, 10, 200, 10}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 160, 200, 160},{ 340, 30, 130, 200, 140},{ 340, 100, 100, 200, 110}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, 200, 180, 40},{ 340, -30, 200, 130, -110},{ 340, -90, 200, 70, 10},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 10, 200, 180, -60},{ 340, 110, 200, 240, 40},{ 340, 200, 200, 200, 200},{ 340, 110, 200, 240, 40}}, +{{ 340, 340, 340, 340, 340},{ 340, -90, 200, 70, 10},{ 340, 200, 200, 200, 200},{ 340, -50, 200, 110, -30},{ 340, -90, 200, 0, -350}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 210, 10},{ 340, 40, 200, 120, -220},{ 340, 110, 200, 190, 30}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 150, 0, 210},{ 340, 200, 40, -150, 70},{ 340, 200, 90, -30, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 90, -100, 110},{ 340, 200, 90, 0, 110},{ 340, 200, 200, 200, 200},{ 340, 200, 90, 0, 110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 90, -30, 190},{ 340, 200, 200, 200, 200},{ 340, 200, 80, -70, 150},{ 340, 200, -90, -390, 10}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -30, 80},{ 340, 200, 40, -260, 140},{ 340, 200, 0, -10, 30}} +} +}, +/* GC....?? */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +} +}, +{ /* noPair */ {{{{0}}}}, +/* GU....CG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 190, 80, 200},{ 340, 190, 180, 70, 200},{ 340, 100, 90, -20, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 240, 220, 110, 200},{ 340, 280, 210, 200, 200},{ 340, 200, 200, 200, 200},{ 340, 270, 190, 180, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 90, -20, 200},{ 340, 200, 200, 200, 200},{ 340, 180, 160, 50, 200},{ 340, 30, -80, -10, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 270, 190, 180, 200},{ 340, 180, 70, 140, 200},{ 340, 220, 100, 180, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 230, 200, 230},{ 340, 170, 160, 200, 160},{ 340, 80, 170, 200, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 210, 200, 210},{ 340, 200, 190, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 180, 180, 200, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 170, 200, 170},{ 340, 200, 200, 200, 200},{ 340, 150, 210, 200, 210},{ 340, -90, 0, 200, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 180, 180, 200, 180},{ 340, 60, 150, 200, 150},{ 340, 90, 90, 200, 90}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 200, 130, 160},{ 340, 70, 200, 120, 50},{ 340, -20, 200, 30, 140},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 200, 170, 90},{ 340, 200, 200, 210, 180},{ 340, 200, 200, 200, 200},{ 340, 180, 200, 200, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, -20, 200, 30, 140},{ 340, 200, 200, 200, 200},{ 340, 50, 200, 110, 130},{ 340, -10, 200, -40, -210}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 180, 200, 200, 160},{ 340, 140, 200, 110, -60},{ 340, 180, 200, 150, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 230, 60, 190},{ 340, 200, 160, -50, 80},{ 340, 200, 170, 40, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 210, 0, 130},{ 340, 200, 190, 80, 110},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 70, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 170, 40, 180},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 40, 170},{ 340, 200, 0, -310, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 70, 100},{ 340, 200, 150, -160, 160},{ 340, 200, 90, 60, 10}} +} +}, +/* GU....GC */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 200, 90, 200},{ 340, 190, 170, 60, 200},{ 340, 10, 0, -110, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 170, 60, 200},{ 340, 250, 170, 160, 200},{ 340, 200, 200, 200, 200},{ 340, 150, 70, 70, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 60, -50, 200},{ 340, 200, 200, 200, 200},{ 340, 180, 160, 50, 200},{ 340, 0, -120, -50, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 250, 180, 170, 200},{ 340, 40, -80, -10, 200},{ 340, 210, 100, 170, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 240, 200, 240},{ 340, 160, 160, 200, 160},{ 340, -10, 80, 200, 80},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 150, 200, 150},{ 340, 160, 160, 200, 160},{ 340, 200, 200, 200, 200},{ 340, 60, 60, 200, 60}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 140, 200, 140},{ 340, 200, 200, 200, 200},{ 340, 150, 210, 200, 210},{ 340, -130, -30, 200, -30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 160, 200, 160},{ 340, -90, 10, 200, 10},{ 340, 90, 80, 200, 80}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 200, 140, 170},{ 340, 60, 200, 120, 40},{ 340, -110, 200, -60, 50},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 200, 110, 40},{ 340, 160, 200, 180, 140},{ 340, 200, 200, 200, 200},{ 340, 70, 200, 80, 50}}, +{{ 340, 340, 340, 340, 340},{ 340, -50, 200, 0, 110},{ 340, 200, 200, 200, 200},{ 340, 50, 200, 110, 130},{ 340, -50, 200, -70, -250}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 180, 150},{ 340, -10, 200, -30, -210},{ 340, 170, 200, 140, 150}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 70, 200},{ 340, 200, 160, -50, 80},{ 340, 200, 80, -50, 80},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 150, -60, 70},{ 340, 200, 160, 50, 80},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -50, -20}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 140, 10, 150},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 40, 170},{ 340, 200, -30, -350, -30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 160, 50, 80},{ 340, 200, 10, -310, 10},{ 340, 200, 80, 50, 0}} +} +}, +/* GU....GU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 250, 240, 130, 200},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 250, 140, 200},{ 340, 310, 230, 220, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 190, 80, 200},{ 340, 130, 20, 90, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 230, 120, 190, 200},{ 340, 270, 150, 220, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 230, 220, 200, 220},{ 340, 130, 220, 200, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 240, 230, 200, 230},{ 340, 220, 220, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 220, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 180, 240, 200, 240},{ 340, 10, 100, 200, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220},{ 340, 110, 200, 200, 200},{ 340, 140, 140, 200, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 230},{ 340, 130, 200, 180, 110},{ 340, 30, 200, 80, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 140, 200, 190, 120},{ 340, 220, 200, 240, 200},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 30, 200, 80, 190},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 140, 160},{ 340, 90, 200, 70, -110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200},{ 340, 190, 200, 160, -10},{ 340, 220, 200, 200, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 220, 10, 140},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 230, 20, 150},{ 340, 200, 220, 100, 140},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 100, -210, 110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 200, -110, 200},{ 340, 200, 140, 110, 60}} +} +}, +/* GU....UG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 230, 220, 110, 200},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 340, 260, 250, 200},{ 340, 200, 200, 200, 200},{ 340, 340, 260, 250, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 200, 90, 200},{ 340, 100, -20, 50, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 220, 110, 180, 200},{ 340, 290, 180, 250, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 210, 200, 200, 200},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 250, 200, 250},{ 340, 250, 250, 200, 250},{ 340, 200, 200, 200, 200},{ 340, 250, 250, 200, 250}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200},{ 340, 190, 240, 200, 240},{ 340, -30, 70, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220},{ 340, 100, 190, 200, 190},{ 340, 170, 160, 200, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 230},{ 340, 110, 200, 160, 90},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 130},{ 340, 250, 200, 270, 230},{ 340, 200, 200, 200, 200},{ 340, 250, 200, 270, 230}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200},{ 340, 90, 200, 140, 170},{ 340, 50, 200, 30, -150}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200},{ 340, 180, 200, 150, -20},{ 340, 250, 200, 220, 230}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 200, -10, 120},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 30, 170},{ 340, 200, 250, 130, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 130, 170}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 70, -250, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 190, -120, 190},{ 340, 200, 160, 130, 80}} +} +}, +/* GU....AU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 250, 240, 130, 200},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 250, 140, 200},{ 340, 310, 230, 220, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 190, 80, 200},{ 340, 130, 20, 90, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 230, 120, 190, 200},{ 340, 270, 150, 220, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 230, 220, 200, 220},{ 340, 130, 220, 200, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 240, 230, 200, 230},{ 340, 220, 220, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 220, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 180, 240, 200, 240},{ 340, 10, 100, 200, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220},{ 340, 110, 200, 200, 200},{ 340, 140, 140, 200, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 230},{ 340, 130, 200, 180, 110},{ 340, 30, 200, 80, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 140, 200, 190, 120},{ 340, 220, 200, 240, 200},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 30, 200, 80, 190},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 140, 160},{ 340, 90, 200, 70, -110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200},{ 340, 190, 200, 160, -10},{ 340, 220, 200, 200, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 220, 10, 140},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 230, 20, 150},{ 340, 200, 220, 100, 140},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 100, -210, 110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 200, -110, 200},{ 340, 200, 140, 110, 60}} +} +}, +/* GU....UA */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 230, 220, 110, 200},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 340, 260, 250, 200},{ 340, 200, 200, 200, 200},{ 340, 340, 260, 250, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 200, 90, 200},{ 340, 100, -20, 50, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 220, 110, 180, 200},{ 340, 290, 180, 250, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 210, 200, 200, 200},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 250, 200, 250},{ 340, 250, 250, 200, 250},{ 340, 200, 200, 200, 200},{ 340, 250, 250, 200, 250}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200},{ 340, 190, 240, 200, 240},{ 340, -30, 70, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220},{ 340, 100, 190, 200, 190},{ 340, 170, 160, 200, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 230},{ 340, 110, 200, 160, 90},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 130},{ 340, 250, 200, 270, 230},{ 340, 200, 200, 200, 200},{ 340, 250, 200, 270, 230}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200},{ 340, 90, 200, 140, 170},{ 340, 50, 200, 30, -150}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200},{ 340, 180, 200, 150, -20},{ 340, 250, 200, 220, 230}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 200, -10, 120},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 30, 170},{ 340, 200, 250, 130, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 130, 170}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 70, -250, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 190, -120, 190},{ 340, 200, 160, 130, 80}} +} +}, +/* GU....?? */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +} +}, +{ /* noPair */ {{{{0}}}}, +/* UG....CG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 100, 200},{ 340, 190, 190, 90, 200},{ 340, 100, 100, 0, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 240, 240, 130, 200},{ 340, 280, 220, 220, 200},{ 340, 200, 200, 200, 200},{ 340, 270, 210, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 100, 0, 200},{ 340, 200, 200, 200, 200},{ 340, 180, 180, 70, 200},{ 340, 30, -70, 10, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 270, 210, 200, 200},{ 340, 180, 80, 160, 200},{ 340, 220, 120, 190, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 260, 200, 230},{ 340, 150, 190, 200, 160},{ 340, 60, 200, 200, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 240, 200, 210},{ 340, 180, 220, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 160, 210, 200, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 200, 200, 170},{ 340, 200, 200, 200, 200},{ 340, 130, 240, 200, 210},{ 340, -110, 30, 200, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 210, 200, 180},{ 340, 40, 180, 200, 150},{ 340, 70, 120, 200, 90}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 140, 150},{ 340, 90, 200, 130, 40},{ 340, 0, 200, 40, 130},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 200, 170, 80},{ 340, 220, 200, 220, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 200, 200, 150}}, +{{ 340, 340, 340, 340, 340},{ 340, 0, 200, 40, 130},{ 340, 200, 200, 200, 200},{ 340, 70, 200, 110, 120},{ 340, 10, 200, -30, -220}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 200, 200, 150},{ 340, 160, 200, 120, -70},{ 340, 190, 200, 150, 150}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 260, 20, 220},{ 340, 200, 190, -90, 110},{ 340, 200, 200, 0, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, -40, 150},{ 340, 200, 220, 40, 140},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 30, 120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 0, 200},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 0, 190},{ 340, 200, 30, -350, 30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 30, 120},{ 340, 200, 180, -200, 180},{ 340, 200, 120, 20, 30}} +} +}, +/* UG....GC */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 210, 110, 200},{ 340, 190, 190, 80, 200},{ 340, 10, 10, -90, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 180, 80, 200},{ 340, 250, 190, 180, 200},{ 340, 200, 200, 200, 200},{ 340, 150, 90, 90, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 70, -30, 200},{ 340, 200, 200, 200, 200},{ 340, 180, 180, 70, 200},{ 340, 0, -100, -30, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 250, 190, 190, 200},{ 340, 40, -60, 10, 200},{ 340, 210, 110, 190, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 270, 200, 240},{ 340, 140, 190, 200, 160},{ 340, -30, 110, 200, 80},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 140, 180, 200, 150},{ 340, 140, 190, 200, 160},{ 340, 200, 200, 200, 200},{ 340, 40, 90, 200, 60}}, +{{ 340, 340, 340, 340, 340},{ 340, 30, 170, 200, 140},{ 340, 200, 200, 200, 200},{ 340, 130, 240, 200, 210},{ 340, -150, 0, 200, -30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 150, 190, 200, 160},{ 340, -110, 40, 200, 10},{ 340, 70, 110, 200, 80}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 200, 150, 160},{ 340, 80, 200, 120, 30},{ 340, -90, 200, -50, 40},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 200, 120, 30},{ 340, 180, 200, 180, 130},{ 340, 200, 200, 200, 200},{ 340, 90, 200, 80, 40}}, +{{ 340, 340, 340, 340, 340},{ 340, -30, 200, 10, 100},{ 340, 200, 200, 200, 200},{ 340, 70, 200, 110, 120},{ 340, -30, 200, -70, -260}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 190, 200, 190, 140},{ 340, 10, 200, -30, -220},{ 340, 190, 200, 150, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 30, 230},{ 340, 200, 190, -90, 100},{ 340, 200, 110, -90, 110},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 180, -100, 100},{ 340, 200, 190, 10, 100},{ 340, 200, 200, 200, 200},{ 340, 200, 90, -90, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 170, -30, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 0, 190},{ 340, 200, 0, -390, -10}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 190, 10, 110},{ 340, 200, 40, -350, 30},{ 340, 200, 110, 10, 30}} +} +}, +/* UG....GU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 250, 250, 150, 200},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 260, 160, 200},{ 340, 310, 250, 240, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 210, 100, 200},{ 340, 130, 30, 110, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200},{ 340, 230, 130, 210, 200},{ 340, 270, 170, 240, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 340, 200, 310},{ 340, 210, 250, 200, 220},{ 340, 110, 250, 200, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 220, 260, 200, 230},{ 340, 200, 250, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 250, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 160, 270, 200, 240},{ 340, -10, 130, 200, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220},{ 340, 90, 230, 200, 200},{ 340, 120, 170, 200, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 220},{ 340, 150, 200, 190, 100},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 200, 200, 110},{ 340, 240, 200, 240, 190},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200},{ 340, 100, 200, 140, 150},{ 340, 110, 200, 70, -120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190},{ 340, 210, 200, 170, -20},{ 340, 240, 200, 200, 190}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 340, 100, 290},{ 340, 200, 250, -30, 170},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 260, -20, 180},{ 340, 200, 250, 70, 160},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200},{ 340, 200, 270, 30, 220},{ 340, 200, 130, -250, 130}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160},{ 340, 200, 230, -150, 230},{ 340, 200, 170, 70, 80}} +} +}, +/* UG....UG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 230, 230, 130, 200},{ 340, 170, 170, 70, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 340, 280, 270, 200},{ 340, 200, 200, 200, 200},{ 340, 340, 280, 270, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 170, 70, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 210, 110, 200},{ 340, 100, 0, 70, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200},{ 340, 220, 120, 200, 200},{ 340, 290, 190, 270, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 340, 200, 310},{ 340, 190, 230, 200, 200},{ 340, 130, 270, 200, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 280, 200, 250},{ 340, 230, 280, 200, 250},{ 340, 200, 200, 200, 200},{ 340, 230, 280, 200, 250}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 270, 200, 240},{ 340, 200, 200, 200, 200},{ 340, 170, 270, 200, 240},{ 340, -50, 100, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220},{ 340, 80, 220, 200, 190},{ 340, 150, 190, 200, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 220},{ 340, 130, 200, 170, 80},{ 340, 70, 200, 110, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 120},{ 340, 270, 200, 270, 220},{ 340, 200, 200, 200, 200},{ 340, 270, 200, 270, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 200, 110, 200},{ 340, 200, 200, 200, 200},{ 340, 110, 200, 150, 160},{ 340, 70, 200, 30, -160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190},{ 340, 200, 200, 160, -30},{ 340, 270, 200, 230, 220}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 340, 100, 290},{ 340, 200, 230, -50, 150},{ 340, 200, 270, 70, 270},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 280, 0, 190},{ 340, 200, 280, 100, 190},{ 340, 200, 200, 200, 200},{ 340, 200, 280, 100, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 70, 270},{ 340, 200, 200, 200, 200},{ 340, 200, 270, 30, 230},{ 340, 200, 100, -290, 90}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160},{ 340, 200, 220, -160, 220},{ 340, 200, 190, 90, 110}} +} +}, +/* UG....AU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 250, 250, 150, 200},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 260, 160, 200},{ 340, 310, 250, 240, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 210, 100, 200},{ 340, 130, 30, 110, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200},{ 340, 230, 130, 210, 200},{ 340, 270, 170, 240, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 340, 200, 310},{ 340, 210, 250, 200, 220},{ 340, 110, 250, 200, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 220, 260, 200, 230},{ 340, 200, 250, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 250, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 160, 270, 200, 240},{ 340, -10, 130, 200, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220},{ 340, 90, 230, 200, 200},{ 340, 120, 170, 200, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 220},{ 340, 150, 200, 190, 100},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 200, 200, 110},{ 340, 240, 200, 240, 190},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200},{ 340, 100, 200, 140, 150},{ 340, 110, 200, 70, -120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190},{ 340, 210, 200, 170, -20},{ 340, 240, 200, 200, 190}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 340, 100, 290},{ 340, 200, 250, -30, 170},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 260, -20, 180},{ 340, 200, 250, 70, 160},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200},{ 340, 200, 270, 30, 220},{ 340, 200, 130, -250, 130}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160},{ 340, 200, 230, -150, 230},{ 340, 200, 170, 70, 80}} +} +}, +/* UG....UA */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 230, 230, 130, 200},{ 340, 170, 170, 70, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 340, 280, 270, 200},{ 340, 200, 200, 200, 200},{ 340, 340, 280, 270, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 170, 70, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 210, 110, 200},{ 340, 100, 0, 70, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200},{ 340, 220, 120, 200, 200},{ 340, 290, 190, 270, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 340, 200, 310},{ 340, 190, 230, 200, 200},{ 340, 130, 270, 200, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 280, 200, 250},{ 340, 230, 280, 200, 250},{ 340, 200, 200, 200, 200},{ 340, 230, 280, 200, 250}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 270, 200, 240},{ 340, 200, 200, 200, 200},{ 340, 170, 270, 200, 240},{ 340, -50, 100, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220},{ 340, 80, 220, 200, 190},{ 340, 150, 190, 200, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 220},{ 340, 130, 200, 170, 80},{ 340, 70, 200, 110, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 120},{ 340, 270, 200, 270, 220},{ 340, 200, 200, 200, 200},{ 340, 270, 200, 270, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 200, 110, 200},{ 340, 200, 200, 200, 200},{ 340, 110, 200, 150, 160},{ 340, 70, 200, 30, -160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190},{ 340, 200, 200, 160, -30},{ 340, 270, 200, 230, 220}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 340, 100, 290},{ 340, 200, 230, -50, 150},{ 340, 200, 270, 70, 270},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 280, 0, 190},{ 340, 200, 280, 100, 190},{ 340, 200, 200, 200, 200},{ 340, 200, 280, 100, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 70, 270},{ 340, 200, 200, 200, 200},{ 340, 200, 270, 30, 230},{ 340, 200, 100, -290, 90}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160},{ 340, 200, 220, -160, 220},{ 340, 200, 190, 90, 110}} +} +}, +/* UG....?? */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +} +}, +{ /* noPair */ {{{{0}}}}, +/* AU....CG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 190, 80, 200},{ 340, 190, 180, 70, 200},{ 340, 100, 90, -20, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 240, 220, 110, 200},{ 340, 280, 210, 200, 200},{ 340, 200, 200, 200, 200},{ 340, 270, 190, 180, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 90, -20, 200},{ 340, 200, 200, 200, 200},{ 340, 180, 160, 50, 200},{ 340, 30, -80, -10, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 270, 190, 180, 200},{ 340, 180, 70, 140, 200},{ 340, 220, 100, 180, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 230, 200, 230},{ 340, 170, 160, 200, 160},{ 340, 80, 170, 200, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 210, 200, 210},{ 340, 200, 190, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 180, 180, 200, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 170, 200, 170},{ 340, 200, 200, 200, 200},{ 340, 150, 210, 200, 210},{ 340, -90, 0, 200, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 180, 180, 200, 180},{ 340, 60, 150, 200, 150},{ 340, 90, 90, 200, 90}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 200, 130, 160},{ 340, 70, 200, 120, 50},{ 340, -20, 200, 30, 140},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 200, 170, 90},{ 340, 200, 200, 210, 180},{ 340, 200, 200, 200, 200},{ 340, 180, 200, 200, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, -20, 200, 30, 140},{ 340, 200, 200, 200, 200},{ 340, 50, 200, 110, 130},{ 340, -10, 200, -40, -210}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 180, 200, 200, 160},{ 340, 140, 200, 110, -60},{ 340, 180, 200, 150, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 230, 60, 190},{ 340, 200, 160, -50, 80},{ 340, 200, 170, 40, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 210, 0, 130},{ 340, 200, 190, 80, 110},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 70, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 170, 40, 180},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 40, 170},{ 340, 200, 0, -310, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 180, 70, 100},{ 340, 200, 150, -160, 160},{ 340, 200, 90, 60, 10}} +} +}, +/* AU....GC */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 200, 90, 200},{ 340, 190, 170, 60, 200},{ 340, 10, 0, -110, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 170, 60, 200},{ 340, 250, 170, 160, 200},{ 340, 200, 200, 200, 200},{ 340, 150, 70, 70, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 60, -50, 200},{ 340, 200, 200, 200, 200},{ 340, 180, 160, 50, 200},{ 340, 0, -120, -50, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 250, 180, 170, 200},{ 340, 40, -80, -10, 200},{ 340, 210, 100, 170, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 240, 200, 240},{ 340, 160, 160, 200, 160},{ 340, -10, 80, 200, 80},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 150, 200, 150},{ 340, 160, 160, 200, 160},{ 340, 200, 200, 200, 200},{ 340, 60, 60, 200, 60}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 140, 200, 140},{ 340, 200, 200, 200, 200},{ 340, 150, 210, 200, 210},{ 340, -130, -30, 200, -30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 160, 200, 160},{ 340, -90, 10, 200, 10},{ 340, 90, 80, 200, 80}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 90, 200, 140, 170},{ 340, 60, 200, 120, 40},{ 340, -110, 200, -60, 50},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 200, 110, 40},{ 340, 160, 200, 180, 140},{ 340, 200, 200, 200, 200},{ 340, 70, 200, 80, 50}}, +{{ 340, 340, 340, 340, 340},{ 340, -50, 200, 0, 110},{ 340, 200, 200, 200, 200},{ 340, 50, 200, 110, 130},{ 340, -50, 200, -70, -250}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 170, 200, 180, 150},{ 340, -10, 200, -30, -210},{ 340, 170, 200, 140, 150}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 70, 200},{ 340, 200, 160, -50, 80},{ 340, 200, 80, -50, 80},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 150, -60, 70},{ 340, 200, 160, 50, 80},{ 340, 200, 200, 200, 200},{ 340, 200, 60, -50, -20}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 140, 10, 150},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 40, 170},{ 340, 200, -30, -350, -30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 160, 50, 80},{ 340, 200, 10, -310, 10},{ 340, 200, 80, 50, 0}} +} +}, +/* AU....GU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 250, 240, 130, 200},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 250, 140, 200},{ 340, 310, 230, 220, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 190, 80, 200},{ 340, 130, 20, 90, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 230, 120, 190, 200},{ 340, 270, 150, 220, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 230, 220, 200, 220},{ 340, 130, 220, 200, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 240, 230, 200, 230},{ 340, 220, 220, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 220, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 180, 240, 200, 240},{ 340, 10, 100, 200, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220},{ 340, 110, 200, 200, 200},{ 340, 140, 140, 200, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 230},{ 340, 130, 200, 180, 110},{ 340, 30, 200, 80, 190},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 140, 200, 190, 120},{ 340, 220, 200, 240, 200},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 30, 200, 80, 190},{ 340, 200, 200, 200, 200},{ 340, 80, 200, 140, 160},{ 340, 90, 200, 70, -110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200},{ 340, 190, 200, 160, -10},{ 340, 220, 200, 200, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 220, 10, 140},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 230, 20, 150},{ 340, 200, 220, 100, 140},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 100, -210, 110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 200, -110, 200},{ 340, 200, 140, 110, 60}} +} +}, +/* AU....UG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 230, 220, 110, 200},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 340, 260, 250, 200},{ 340, 200, 200, 200, 200},{ 340, 340, 260, 250, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 200, 90, 200},{ 340, 100, -20, 50, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 220, 110, 180, 200},{ 340, 290, 180, 250, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 210, 200, 200, 200},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 250, 200, 250},{ 340, 250, 250, 200, 250},{ 340, 200, 200, 200, 200},{ 340, 250, 250, 200, 250}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200},{ 340, 190, 240, 200, 240},{ 340, -30, 70, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220},{ 340, 100, 190, 200, 190},{ 340, 170, 160, 200, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 230},{ 340, 110, 200, 160, 90},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 130},{ 340, 250, 200, 270, 230},{ 340, 200, 200, 200, 200},{ 340, 250, 200, 270, 230}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200},{ 340, 90, 200, 140, 170},{ 340, 50, 200, 30, -150}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200},{ 340, 180, 200, 150, -20},{ 340, 250, 200, 220, 230}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 200, -10, 120},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 30, 170},{ 340, 200, 250, 130, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 130, 170}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 70, -250, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 190, -120, 190},{ 340, 200, 160, 130, 80}} +} +}, +/* AU....AU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 250, 240, 130, 200},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 250, 140, 200},{ 340, 310, 230, 220, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 140, 30, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 190, 80, 200},{ 340, 130, 20, 90, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 230, 120, 190, 200},{ 340, 270, 150, 220, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 230, 220, 200, 220},{ 340, 130, 220, 200, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 240, 230, 200, 230},{ 340, 220, 220, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220}}, 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340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 220, 10, 140},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 230, 20, 150},{ 340, 200, 220, 100, 140},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 220, 90, 220},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 100, -210, 110}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 200, -110, 200},{ 340, 200, 140, 110, 60}} +} +}, +/* AU....UA */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 230, 220, 110, 200},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 260, 150, 200},{ 340, 340, 260, 250, 200},{ 340, 200, 200, 200, 200},{ 340, 340, 260, 250, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 160, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 200, 90, 200},{ 340, 100, -20, 50, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 230, 220, 200},{ 340, 220, 110, 180, 200},{ 340, 290, 180, 250, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 310, 200, 310},{ 340, 210, 200, 200, 200},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 250, 250, 200, 250},{ 340, 250, 250, 200, 250},{ 340, 200, 200, 200, 200},{ 340, 250, 250, 200, 250}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 240, 200, 240},{ 340, 200, 200, 200, 200},{ 340, 190, 240, 200, 240},{ 340, -30, 70, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 220, 200, 220},{ 340, 100, 190, 200, 190},{ 340, 170, 160, 200, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 230},{ 340, 110, 200, 160, 90},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 200, 210, 130},{ 340, 250, 200, 270, 230},{ 340, 200, 200, 200, 200},{ 340, 250, 200, 270, 230}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 100, 210},{ 340, 200, 200, 200, 200},{ 340, 90, 200, 140, 170},{ 340, 50, 200, 30, -150}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 220, 200, 240, 200},{ 340, 180, 200, 150, -20},{ 340, 250, 200, 220, 230}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 310, 130, 270},{ 340, 200, 200, -10, 120},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 30, 170},{ 340, 200, 250, 130, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 130, 170}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, 110, 240},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 70, 200},{ 340, 200, 70, -250, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 220, 100, 140},{ 340, 200, 190, -120, 190},{ 340, 200, 160, 130, 80}} +} +}, +/* AU....?? */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +} +}, +{ /* noPair */ {{{{0}}}}, +/* UA....CG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 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30, -70, 10, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 270, 210, 200, 200},{ 340, 180, 80, 160, 200},{ 340, 220, 120, 190, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 260, 200, 230},{ 340, 150, 190, 200, 160},{ 340, 60, 200, 200, 170},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 190, 240, 200, 210},{ 340, 180, 220, 200, 190},{ 340, 200, 200, 200, 200},{ 340, 160, 210, 200, 180}}, +{{ 340, 340, 340, 340, 340},{ 340, 60, 200, 200, 170},{ 340, 200, 200, 200, 200},{ 340, 130, 240, 200, 210},{ 340, -110, 30, 200, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 160, 210, 200, 180},{ 340, 40, 180, 200, 150},{ 340, 70, 120, 200, 90}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 100, 200, 140, 150},{ 340, 90, 200, 130, 40},{ 340, 0, 200, 40, 130},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 200, 170, 80},{ 340, 220, 200, 220, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 200, 200, 150}}, +{{ 340, 340, 340, 340, 340},{ 340, 0, 200, 40, 130},{ 340, 200, 200, 200, 200},{ 340, 70, 200, 110, 120},{ 340, 10, 200, -30, -220}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 200, 200, 150},{ 340, 160, 200, 120, -70},{ 340, 190, 200, 150, 150}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 260, 20, 220},{ 340, 200, 190, -90, 110},{ 340, 200, 200, 0, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 240, -40, 150},{ 340, 200, 220, 40, 140},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 30, 120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 0, 200},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 0, 190},{ 340, 200, 30, -350, 30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 210, 30, 120},{ 340, 200, 180, -200, 180},{ 340, 200, 120, 20, 30}} +} +}, +/* UA....GC */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 210, 210, 110, 200},{ 340, 190, 190, 80, 200},{ 340, 10, 10, -90, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 180, 180, 80, 200},{ 340, 250, 190, 180, 200},{ 340, 200, 200, 200, 200},{ 340, 150, 90, 90, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 70, -30, 200},{ 340, 200, 200, 200, 200},{ 340, 180, 180, 70, 200},{ 340, 0, -100, -30, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 250, 190, 190, 200},{ 340, 40, -60, 10, 200},{ 340, 210, 110, 190, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 270, 200, 240},{ 340, 140, 190, 200, 160},{ 340, -30, 110, 200, 80},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 140, 180, 200, 150},{ 340, 140, 190, 200, 160},{ 340, 200, 200, 200, 200},{ 340, 40, 90, 200, 60}}, +{{ 340, 340, 340, 340, 340},{ 340, 30, 170, 200, 140},{ 340, 200, 200, 200, 200},{ 340, 130, 240, 200, 210},{ 340, -150, 0, 200, -30}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 150, 190, 200, 160},{ 340, -110, 40, 200, 10},{ 340, 70, 110, 200, 80}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 200, 150, 160},{ 340, 80, 200, 120, 30},{ 340, -90, 200, -50, 40},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 80, 200, 120, 30},{ 340, 180, 200, 180, 130},{ 340, 200, 200, 200, 200},{ 340, 90, 200, 80, 40}}, +{{ 340, 340, 340, 340, 340},{ 340, -30, 200, 10, 100},{ 340, 200, 200, 200, 200},{ 340, 70, 200, 110, 120},{ 340, -30, 200, -70, -260}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 190, 200, 190, 140},{ 340, 10, 200, -30, -220},{ 340, 190, 200, 150, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 30, 230},{ 340, 200, 190, -90, 100},{ 340, 200, 110, -90, 110},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 180, -100, 100},{ 340, 200, 190, 10, 100},{ 340, 200, 200, 200, 200},{ 340, 200, 90, -90, 0}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 170, -30, 170},{ 340, 200, 200, 200, 200},{ 340, 200, 240, 0, 190},{ 340, 200, 0, -390, -10}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 190, 10, 110},{ 340, 200, 40, -350, 30},{ 340, 200, 110, 10, 30}} +} +}, +/* UA....GU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 250, 250, 150, 200},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 260, 160, 200},{ 340, 310, 250, 240, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 210, 100, 200},{ 340, 130, 30, 110, 200}}, 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340, 340, 340},{ 340, 170, 200, 210, 220},{ 340, 150, 200, 190, 100},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 200, 200, 110},{ 340, 240, 200, 240, 190},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200},{ 340, 100, 200, 140, 150},{ 340, 110, 200, 70, -120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190},{ 340, 210, 200, 170, -20},{ 340, 240, 200, 200, 190}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 340, 100, 290},{ 340, 200, 250, -30, 170},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 260, -20, 180},{ 340, 200, 250, 70, 160},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200},{ 340, 200, 270, 30, 220},{ 340, 200, 130, -250, 130}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160},{ 340, 200, 230, -150, 230},{ 340, 200, 170, 70, 80}} +} +}, +/* UA....UG */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 230, 230, 130, 200},{ 340, 170, 170, 70, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 340, 280, 270, 200},{ 340, 200, 200, 200, 200},{ 340, 340, 280, 270, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 170, 70, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 210, 110, 200},{ 340, 100, 0, 70, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200},{ 340, 220, 120, 200, 200},{ 340, 290, 190, 270, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 340, 200, 310},{ 340, 190, 230, 200, 200},{ 340, 130, 270, 200, 240},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 280, 200, 250},{ 340, 230, 280, 200, 250},{ 340, 200, 200, 200, 200},{ 340, 230, 280, 200, 250}}, +{{ 340, 340, 340, 340, 340},{ 340, 130, 270, 200, 240},{ 340, 200, 200, 200, 200},{ 340, 170, 270, 200, 240},{ 340, -50, 100, 200, 70}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220},{ 340, 80, 220, 200, 190},{ 340, 150, 190, 200, 160}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 220},{ 340, 130, 200, 170, 80},{ 340, 70, 200, 110, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 120},{ 340, 270, 200, 270, 220},{ 340, 200, 200, 200, 200},{ 340, 270, 200, 270, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 70, 200, 110, 200},{ 340, 200, 200, 200, 200},{ 340, 110, 200, 150, 160},{ 340, 70, 200, 30, -160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190},{ 340, 200, 200, 160, -30},{ 340, 270, 200, 230, 220}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 340, 100, 290},{ 340, 200, 230, -50, 150},{ 340, 200, 270, 70, 270},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 280, 0, 190},{ 340, 200, 280, 100, 190},{ 340, 200, 200, 200, 200},{ 340, 200, 280, 100, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 270, 70, 270},{ 340, 200, 200, 200, 200},{ 340, 200, 270, 30, 230},{ 340, 200, 100, -290, 90}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160},{ 340, 200, 220, -160, 220},{ 340, 200, 190, 90, 110}} +} +}, +/* UA....AU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 280, 280, 170, 200},{ 340, 250, 250, 150, 200},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 260, 260, 160, 200},{ 340, 310, 250, 240, 200},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 150, 150, 50, 200},{ 340, 200, 200, 200, 200},{ 340, 210, 210, 100, 200},{ 340, 130, 30, 110, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 310, 250, 240, 200},{ 340, 230, 130, 210, 200},{ 340, 270, 170, 240, 200}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 230, 340, 200, 310},{ 340, 210, 250, 200, 220},{ 340, 110, 250, 200, 220},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 220, 260, 200, 230},{ 340, 200, 250, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220}}, +{{ 340, 340, 340, 340, 340},{ 340, 110, 250, 200, 220},{ 340, 200, 200, 200, 200},{ 340, 160, 270, 200, 240},{ 340, -10, 130, 200, 100}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 200, 220},{ 340, 90, 230, 200, 200},{ 340, 120, 170, 200, 140}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 170, 200, 210, 220},{ 340, 150, 200, 190, 100},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 160, 200, 200, 110},{ 340, 240, 200, 240, 190},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190}}, +{{ 340, 340, 340, 340, 340},{ 340, 50, 200, 90, 180},{ 340, 200, 200, 200, 200},{ 340, 100, 200, 140, 150},{ 340, 110, 200, 70, -120}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 240, 200, 240, 190},{ 340, 210, 200, 170, -20},{ 340, 240, 200, 200, 190}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 340, 100, 290},{ 340, 200, 250, -30, 170},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 260, -20, 180},{ 340, 200, 250, 70, 160},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 250, 50, 250},{ 340, 200, 200, 200, 200},{ 340, 200, 270, 30, 220},{ 340, 200, 130, -250, 130}}, +{{ 340, 340, 340, 340, 340},{ 340, 200, 200, 200, 200},{ 340, 200, 250, 70, 160},{ 340, 200, 230, -150, 230},{ 340, 200, 170, 70, 80}} +} +}, +/* UA....UA */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 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340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +}, +/* ??....AU */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +}, +/* ??....UA */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +}, +/* ??....?? */ +{{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +}, +{ +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}}, +{{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340},{ 340, 340, 340, 340, 340}} +} +} +} +}; + +PRIVATE int int22_H_184[NBPAIRS+1][NBPAIRS+1][5][5][5][5] = +{ /* noPair */ {{{{{0}}}}}, +{ /* noPair */ {{{{0}}}}, +/* CG.@@..CG */ +{ { { { 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@A..CG */ +{ { 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* CG.@C..CG */ +{ { 0, 0, 0, 0, 0}, +{ -949, -949, -949, -949, -949}, +{ -449, -449, -449, -449, -449}, +{ -939, -939, -939, -939, -939}, +{ -739, -739, -739, -739, -739}}, +/* CG.@G..CG */ +{ { 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* CG.@U..CG */ +{ { 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -669, -669, -669, -669, -669}, +{ -939, -939, -939, -939, -939}, +{ -859, -859, -859, -859, -859}}}, +/* CG.A@..CG */ +{{{ DEF,-1029, -949,-1029,-1029}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AA..CG */ +{{ DEF,-1029, -949,-1029,-1029}, +{-1079,-2058,-1978,-2058,-2058}, +{ -569,-1548,-1468,-1548,-1548}, +{ -989,-1968,-1888,-1968,-1968}, +{ -859,-1838,-1758,-1838,-1838}}, +/* CG.AC..CG */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -999,-1978,-1898,-1978,-1978}, +{ -499,-1478,-1398,-1478,-1478}, +{ -989,-1968,-1888,-1968,-1968}, +{ -789,-1768,-1688,-1768,-1768}}, +/* CG.AG..CG */ +{{ DEF,-1029, -949,-1029,-1029}, +{-1079,-2058,-1978,-2058,-2058}, +{ -569,-1548,-1468,-1548,-1548}, +{ -989,-1968,-1888,-1968,-1968}, +{ -859,-1838,-1758,-1838,-1838}}, +/* CG.AU..CG */ +{{ DEF,-1029, -949,-1029,-1029}, +{-1079,-2058,-1978,-2058,-2058}, +{ -719,-1698,-1618,-1698,-1698}, +{ -989,-1968,-1888,-1968,-1968}, +{ -909,-1888,-1808,-1888,-1888}}}, +/* CG.C@..CG */ +{{{ DEF, -519, -449, -519, -669}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CA..CG */ +{{ DEF, -519, -449, -519, -669}, +{-1079,-1548,-1478,-1548,-1698}, +{ -569,-1038, -968,-1038,-1188}, +{ -989,-1458,-1388,-1458,-1608}, +{ -859,-1328,-1258,-1328,-1478}}, +/* CG.CC..CG */ +{{ DEF, -519, -449, -519, -669}, +{ -999,-1468,-1398,-1468,-1618}, +{ -499, -968, -898, -968,-1118}, +{ -989,-1458,-1388,-1458,-1608}, +{ -789,-1258,-1188,-1258,-1408}}, +/* CG.CG..CG */ +{{ DEF, -519, -449, -519, -669}, +{-1079,-1548,-1478,-1548,-1698}, +{ -569,-1038, -968,-1038,-1188}, +{ -989,-1458,-1388,-1458,-1608}, +{ -859,-1328,-1258,-1328,-1478}}, +/* CG.CU..CG */ +{{ DEF, -519, -449, -519, -669}, +{-1079,-1548,-1478,-1548,-1698}, +{ -719,-1188,-1118,-1188,-1338}, +{ -989,-1458,-1388,-1458,-1608}, +{ -909,-1378,-1308,-1378,-1528}}}, +/* CG.G@..CG */ +{{{ DEF, -939, -939, -939, -939}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GA..CG */ +{{ DEF, -939, -939, -939, -939}, +{-1079,-1968,-1968,-1968,-1968}, +{ -569,-1458,-1458,-1458,-1458}, +{ -989,-1878,-1878,-1878,-1878}, +{ -859,-1748,-1748,-1748,-1748}}, +/* CG.GC..CG */ +{{ DEF, -939, -939, -939, -939}, +{ -999,-1888,-1888,-1888,-1888}, +{ -499,-1388,-1388,-1388,-1388}, +{ -989,-1878,-1878,-1878,-1878}, +{ -789,-1678,-1678,-1678,-1678}}, +/* CG.GG..CG */ +{{ DEF, -939, -939, -939, -939}, +{-1079,-1968,-1968,-1968,-1968}, +{ -569,-1458,-1458,-1458,-1458}, +{ -989,-1878,-1878,-1878,-1878}, +{ -859,-1748,-1748,-1748,-1748}}, +/* CG.GU..CG */ +{{ DEF, -939, -939, -939, -939}, +{-1079,-1968,-1968,-1968,-1968}, +{ -719,-1608,-1608,-1608,-1608}, +{ -989,-1878,-1878,-1878,-1878}, +{ -909,-1798,-1798,-1798,-1798}}}, +/* CG.U@..CG */ +{{{ DEF, -809, -739, -809, -859}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UA..CG */ +{{ DEF, -809, -739, -809, -859}, +{-1079,-1838,-1768,-1838,-1888}, +{ -569,-1328,-1258,-1328,-1378}, +{ -989,-1748,-1678,-1748,-1798}, +{ -859,-1618,-1548,-1618,-1668}}, +/* CG.UC..CG */ +{{ DEF, -809, -739, -809, -859}, +{ -999,-1758,-1688,-1758,-1808}, +{ -499,-1258,-1188,-1258,-1308}, +{ -989,-1748,-1678,-1748,-1798}, +{ -789,-1548,-1478,-1548,-1598}}, +/* CG.UG..CG */ +{{ DEF, -809, -739, -809, -859}, +{-1079,-1838,-1768,-1838,-1888}, +{ -569,-1328,-1258,-1328,-1378}, +{ -989,-1748,-1678,-1748,-1798}, +{ -859,-1618,-1548,-1618,-1668}}, +/* CG.UU..CG */ +{{ DEF, -809, -739, -809, -859}, +{-1079,-1838,-1768,-1838,-1888}, +{ -719,-1478,-1408,-1478,-1528}, +{ -989,-1748,-1678,-1748,-1798}, +{ -909,-1668,-1598,-1668,-1718}}}}, +/* CG.@@..GC */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@A..GC */ +{{ 0, 0, 0, 0, 0}, +{ -519, -519, -519, -519, -519}, +{ -719, -719, -719, -719, -719}, +{ -709, -709, -709, -709, -709}, +{ -499, -499, -499, -499, -499}}, +/* CG.@C..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -309, -309, -309, -309, -309}, +{ -739, -739, -739, -739, -739}, +{ -499, -499, -499, -499, -499}}, +/* CG.@G..GC */ +{{ 0, 0, 0, 0, 0}, +{ -559, -559, -559, -559, -559}, +{ -309, -309, -309, -309, -309}, +{ -619, -619, -619, -619, -619}, +{ -499, -499, -499, -499, -499}}, +/* CG.@U..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -389, -389, -389, -389, -389}, +{ -739, -739, -739, -739, -739}, +{ -569, -569, -569, -569, -569}}}, +/* CG.A@..GC */ +{{{ DEF,-1029, -949,-1029,-1029}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AA..GC */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -569,-1548,-1468,-1548,-1548}, +{ -769,-1748,-1668,-1748,-1748}, +{ -759,-1738,-1658,-1738,-1738}, +{ -549,-1528,-1448,-1528,-1528}}, +/* CG.AC..GC */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -929,-1908,-1828,-1908,-1908}, +{ -359,-1338,-1258,-1338,-1338}, +{ -789,-1768,-1688,-1768,-1768}, +{ -549,-1528,-1448,-1528,-1528}}, +/* CG.AG..GC */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -609,-1588,-1508,-1588,-1588}, +{ -359,-1338,-1258,-1338,-1338}, +{ -669,-1648,-1568,-1648,-1648}, +{ -549,-1528,-1448,-1528,-1528}}, +/* CG.AU..GC */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -929,-1908,-1828,-1908,-1908}, +{ -439,-1418,-1338,-1418,-1418}, +{ -789,-1768,-1688,-1768,-1768}, +{ -619,-1598,-1518,-1598,-1598}}}, +/* CG.C@..GC */ +{{{ DEF, -519, -449, -519, -669}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CA..GC */ +{{ DEF, -519, -449, -519, -669}, +{ -569,-1038, -968,-1038,-1188}, +{ -769,-1238,-1168,-1238,-1388}, +{ -759,-1228,-1158,-1228,-1378}, +{ -549,-1018, -948,-1018,-1168}}, +/* CG.CC..GC */ +{{ DEF, -519, -449, -519, -669}, +{ -929,-1398,-1328,-1398,-1548}, +{ -359, -828, -758, -828, -978}, +{ -789,-1258,-1188,-1258,-1408}, +{ -549,-1018, -948,-1018,-1168}}, +/* CG.CG..GC */ +{{ DEF, -519, -449, -519, -669}, +{ -609,-1078,-1008,-1078,-1228}, +{ -359, -828, -758, -828, -978}, +{ -669,-1138,-1068,-1138,-1288}, +{ -549,-1018, -948,-1018,-1168}}, +/* CG.CU..GC */ +{{ DEF, -519, -449, -519, -669}, +{ -929,-1398,-1328,-1398,-1548}, +{ -439, -908, -838, -908,-1058}, +{ -789,-1258,-1188,-1258,-1408}, +{ -619,-1088,-1018,-1088,-1238}}}, +/* CG.G@..GC */ +{{{ DEF, -939, -939, -939, -939}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GA..GC */ +{{ DEF, -939, -939, -939, -939}, +{ -569,-1458,-1458,-1458,-1458}, +{ -769,-1658,-1658,-1658,-1658}, +{ -759,-1648,-1648,-1648,-1648}, +{ -549,-1438,-1438,-1438,-1438}}, +/* CG.GC..GC */ +{{ DEF, -939, -939, -939, -939}, +{ -929,-1818,-1818,-1818,-1818}, +{ -359,-1248,-1248,-1248,-1248}, +{ -789,-1678,-1678,-1678,-1678}, +{ -549,-1438,-1438,-1438,-1438}}, +/* CG.GG..GC */ +{{ DEF, -939, -939, -939, -939}, +{ -609,-1498,-1498,-1498,-1498}, +{ -359,-1248,-1248,-1248,-1248}, +{ -669,-1558,-1558,-1558,-1558}, +{ -549,-1438,-1438,-1438,-1438}}, +/* CG.GU..GC */ +{{ DEF, -939, -939, -939, -939}, +{ -929,-1818,-1818,-1818,-1818}, +{ -439,-1328,-1328,-1328,-1328}, +{ -789,-1678,-1678,-1678,-3080}, +{ -619,-1508,-1508,-1508,-1508}}}, +/* CG.U@..GC */ +{{{ DEF, -809, -739, -809, -859}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UA..GC */ +{{ DEF, -809, -739, -809, -859}, +{ -569,-1328,-1258,-1328,-1378}, +{ -769,-1528,-1458,-1528,-1578}, +{ -759,-1518,-1448,-1518,-1568}, +{ -549,-1308,-1238,-1308,-1358}}, +/* CG.UC..GC */ +{{ DEF, -809, -739, -809, -859}, +{ -929,-1688,-1618,-1688,-1738}, +{ -359,-1118,-1048,-1118,-1168}, +{ -789,-1548,-1478,-1548,-1598}, +{ -549,-1308,-1238,-1308,-1358}}, +/* CG.UG..GC */ +{{ DEF, -809, -739, -809, -859}, +{ -609,-1368,-1298,-1368,-1418}, +{ -359,-1118,-1048,-1118,-1168}, +{ -669,-1428,-1358,-1428,-1478}, +{ -549,-1308,-1238,-1308,-1358}}, +/* CG.UU..GC */ +{{ DEF, -809, -739, -809, -859}, +{ -929,-1688,-1618,-1688,-1738}, +{ -439,-1198,-1128,-1198,-1248}, +{ -789,-1548,-1478,-1548,-1598}, +{ -619,-1378,-1308,-1378,-1428}}}}, +/* CG.@@..GU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@A..GU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* CG.@C..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* CG.@G..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* CG.@U..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* CG.A@..GU */ +{{{ DEF,-1029, -949,-1029,-1029}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AA..GU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -479,-1458,-1378,-1458,-1458}, +{ -309,-1288,-1208,-1288,-1288}, +{ -389,-1368,-1288,-1368,-1368}, +{ -379,-1358,-1278,-1358,-1358}}, +/* CG.AC..GU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -649,-1628,-1548,-1628,-1628}, +{ -289,-1268,-1188,-1268,-1268}, +{ -739,-1718,-1638,-1718,-1718}, +{ -379,-1358,-1278,-1358,-1358}}, +/* CG.AG..GU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -649,-1628,-1548,-1628,-1628}, +{ -289,-1268,-1188,-1268,-1268}, +{ -739,-1718,-1638,-1718,-1718}, +{ -379,-1358,-1278,-1358,-1358}}, +/* CG.AU..GU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -649,-1628,-1548,-1628,-1628}, +{ -289,-1268,-1188,-1268,-1268}, +{ -739,-1718,-1638,-1718,-1718}, +{ -379,-1358,-1278,-1358,-1358}}}, +/* CG.C@..GU */ +{{{ DEF, -519, -449, -519, -669}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CA..GU */ +{{ DEF, -519, -449, -519, -669}, +{ -479, -948, -878, -948,-1098}, +{ -309, -778, -708, -778, -928}, +{ -389, -858, -788, -858,-1008}, +{ -379, -848, -778, -848, -998}}, +/* CG.CC..GU */ +{{ DEF, -519, -449, -519, -669}, +{ -649,-1118,-1048,-1118,-1268}, +{ -289, -758, -688, -758, -908}, +{ -739,-1208,-1138,-1208,-1358}, +{ -379, -848, -778, -848, -998}}, +/* CG.CG..GU */ +{{ DEF, -519, -449, -519, -669}, +{ -649,-1118,-1048,-1118,-1268}, +{ -289, -758, -688, -758, -908}, +{ -739,-1208,-1138,-1208,-1358}, +{ -379, -848, -778, -848, -998}}, +/* CG.CU..GU */ +{{ DEF, -519, -449, -519, -669}, +{ -649,-1118,-1048,-1118,-1268}, +{ -289, -758, -688, -758, -908}, +{ -739,-1208,-1138,-1208,-1358}, +{ -379, -848, -778, -848, -998}}}, +/* CG.G@..GU */ +{{{ DEF, -939, -939, -939, -939}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GA..GU */ +{{ DEF, -939, -939, -939, -939}, +{ -479,-1368,-1368,-1368,-1368}, +{ -309,-1198,-1198,-1198,-1198}, +{ -389,-1278,-1278,-1278,-1278}, +{ -379,-1268,-1268,-1268,-1268}}, +/* CG.GC..GU */ +{{ DEF, -939, -939, -939, -939}, +{ -649,-1538,-1538,-1538,-1538}, +{ -289,-1178,-1178,-1178,-1178}, +{ -739,-1628,-1628,-1628,-1628}, +{ -379,-1268,-1268,-1268,-1268}}, +/* CG.GG..GU */ +{{ DEF, -939, -939, -939, -939}, +{ -649,-1538,-1538,-1538,-1538}, +{ -289,-1178,-1178,-1178,-1178}, +{ -739,-1628,-1628,-1628,-1628}, +{ -379,-1268,-1268,-1268,-1268}}, +/* CG.GU..GU */ +{{ DEF, -939, -939, -939, -939}, +{ -649,-1538,-1538,-1538,-1538}, +{ -289,-1178,-1178,-1178,-1178}, +{ -739,-1628,-1628,-1628,-1628}, +{ -379,-1268,-1268,-1268,-1268}}}, +/* CG.U@..GU */ +{{{ DEF, -809, -739, -809, -859}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UA..GU */ +{{ DEF, -809, -739, -809, -859}, +{ -479,-1238,-1168,-1238,-1288}, +{ -309,-1068, -998,-1068,-1118}, +{ -389,-1148,-1078,-1148,-1198}, +{ -379,-1138,-1068,-1138,-1188}}, +/* CG.UC..GU */ +{{ DEF, -809, -739, -809, -859}, +{ -649,-1408,-1338,-1408,-1458}, +{ -289,-1048, -978,-1048,-1098}, +{ -739,-1498,-1428,-1498,-1548}, +{ -379,-1138,-1068,-1138,-1188}}, +/* CG.UG..GU */ +{{ DEF, -809, -739, -809, -859}, +{ -649,-1408,-1338,-1408,-1458}, +{ -289,-1048, -978,-1048,-1098}, +{ -739,-1498,-1428,-1498,-1548}, +{ -379,-1138,-1068,-1138,-1188}}, +/* CG.UU..GU */ +{{ DEF, -809, -739, -809, -859}, +{ -649,-1408,-1338,-1408,-1458}, +{ -289,-1048, -978,-1048,-1098}, +{ -739,-1498,-1428,-1498,-1548}, +{ -379,-1138,-1068,-1138,-1188}}}}, +/* CG.@@..UG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@A..UG */ +{{ 0, 0, 0, 0, 0}, +{ -719, -719, -719, -719, -719}, +{ -479, -479, -479, -479, -479}, +{ -659, -659, -659, -659, -659}, +{ -549, -549, -549, -549, -549}}, +/* CG.@C..UG */ +{{ 0, 0, 0, 0, 0}, +{ -789, -789, -789, -789, -789}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -439, -439, -439, -439, -439}}, +/* CG.@G..UG */ +{{ 0, 0, 0, 0, 0}, +{ -959, -959, -959, -959, -959}, +{ -359, -359, -359, -359, -359}, +{ -919, -919, -919, -919, -919}, +{ -549, -549, -549, -549, -549}}, +/* CG.@U..UG */ +{{ 0, 0, 0, 0, 0}, +{ -809, -809, -809, -809, -809}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -359, -359, -359, -359, -359}}}, +/* CG.A@..UG */ +{{{ DEF,-1029, -949,-1029,-1029}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AA..UG */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -769,-1748,-1668,-1748,-1748}, +{ -529,-1508,-1428,-1508,-1508}, +{ -709,-1688,-1608,-1688,-1688}, +{ -599,-1578,-1498,-1578,-1578}}, +/* CG.AC..UG */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -839,-1818,-1738,-1818,-1818}, +{ -529,-1508,-1428,-1508,-1508}, +{ -859,-1838,-1758,-1838,-1838}, +{ -489,-1468,-1388,-1468,-1468}}, +/* CG.AG..UG */ +{{ DEF,-1029, -949,-1029,-1029}, +{-1009,-1988,-1908,-1988,-1988}, +{ -409,-1388,-1308,-1388,-1388}, +{ -969,-1948,-1868,-1948,-1948}, +{ -599,-1578,-1498,-1578,-1578}}, +/* CG.AU..UG */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -859,-1838,-1758,-1838,-1838}, +{ -529,-1508,-1428,-1508,-1508}, +{ -859,-1838,-1758,-1838,-1838}, +{ -409,-1388,-1308,-1388,-1388}}}, +/* CG.C@..UG */ +{{{ DEF, -519, -449, -519, -669}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CA..UG */ +{{ DEF, -519, -449, -519, -669}, +{ -769,-1238,-1168,-1238,-1388}, +{ -529, -998, -928, -998,-1148}, +{ -709,-1178,-1108,-1178,-1328}, +{ -599,-1068, -998,-1068,-1218}}, +/* CG.CC..UG */ +{{ DEF, -519, -449, -519, -669}, +{ -839,-1308,-1238,-1308,-1458}, +{ -529, -998, -928, -998,-1148}, +{ -859,-1328,-1258,-1328,-1478}, +{ -489, -958, -888, -958,-1108}}, +/* CG.CG..UG */ +{{ DEF, -519, -449, -519, -669}, +{-1009,-1478,-1408,-1478,-1628}, +{ -409, -878, -808, -878,-1028}, +{ -969,-1438,-1368,-1438,-1588}, +{ -599,-1068, -998,-1068,-1218}}, +/* CG.CU..UG */ +{{ DEF, -519, -449, -519, -669}, +{ -859,-1328,-1258,-1328,-1478}, +{ -529, -998, -928, -998,-1148}, +{ -859,-1328,-1258,-1328,-1478}, +{ -409, -878, -808, -878,-1028}}}, +/* CG.G@..UG */ +{{{ DEF, -939, -939, -939, -939}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GA..UG */ +{{ DEF, -939, -939, -939, -939}, +{ -769,-1658,-1658,-1658,-1658}, +{ -529,-1418,-1418,-1418,-1418}, +{ -709,-1598,-1598,-1598,-1598}, +{ -599,-1488,-1488,-1488,-1488}}, +/* CG.GC..UG */ +{{ DEF, -939, -939, -939, -939}, +{ -839,-1728,-1728,-1728,-1728}, +{ -529,-1418,-1418,-1418,-1418}, +{ -859,-1748,-1748,-1748,-1748}, +{ -489,-1378,-1378,-1378,-1378}}, +/* CG.GG..UG */ +{{ DEF, -939, -939, -939, -939}, +{-1009,-1898,-1898,-1898,-1898}, +{ -409,-1298,-1298,-1298,-1298}, +{ -969,-1858,-1858,-1858,-1858}, +{ -599,-1488,-1488,-1488,-1488}}, +/* CG.GU..UG */ +{{ DEF, -939, -939, -939, -939}, +{ -859,-1748,-1748,-1748,-1748}, +{ -529,-1418,-1418,-1418,-1418}, +{ -859,-1748,-1748,-1748,-1748}, +{ -409,-1298,-1298,-1298,-1298}}}, +/* CG.U@..UG */ +{{{ DEF, -809, -739, -809, -859}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UA..UG */ +{{ DEF, -809, -739, -809, -859}, +{ -769,-1528,-1458,-1528,-1578}, +{ -529,-1288,-1218,-1288,-1338}, +{ -709,-1468,-1398,-1468,-1518}, +{ -599,-1358,-1288,-1358,-1408}}, +/* CG.UC..UG */ +{{ DEF, -809, -739, -809, -859}, +{ -839,-1598,-1528,-1598,-1648}, +{ -529,-1288,-1218,-1288,-1338}, +{ -859,-1618,-1548,-1618,-1668}, +{ -489,-1248,-1178,-1248,-1298}}, +/* CG.UG..UG */ +{{ DEF, -809, -739, -809, -859}, +{-1009,-1768,-1698,-1768,-1818}, +{ -409,-1168,-1098,-1168,-1218}, +{ -969,-1728,-1658,-1728,-1778}, +{ -599,-1358,-1288,-1358,-1408}}, +/* CG.UU..UG */ +{{ DEF, -809, -739, -809, -859}, +{ -859,-1618,-1548,-1618,-1668}, +{ -529,-1288,-1218,-1288,-1338}, +{ -859,-1618,-1548,-1618,-1668}, +{ -409,-1168,-1098,-1168,-1218}}}}, +/* CG.@@..AU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@A..AU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* CG.@C..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* CG.@G..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* CG.@U..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* CG.A@..AU */ +{{{ DEF,-1029, -949,-1029,-1029}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AA..AU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -479,-1458,-1378,-1458,-1458}, +{ -309,-1288,-1208,-1288,-1288}, +{ -389,-1368,-1288,-1368,-1368}, +{ -379,-1358,-1278,-1358,-1358}}, +/* CG.AC..AU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -649,-1628,-1548,-1628,-1628}, +{ -289,-1268,-1188,-1268,-1268}, +{ -739,-1718,-1638,-1718,-1718}, +{ -379,-1358,-1278,-1358,-1358}}, +/* CG.AG..AU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -649,-1628,-1548,-1628,-1628}, +{ -289,-1268,-1188,-1268,-1268}, +{ -739,-1718,-1638,-1718,-1718}, +{ -379,-1358,-1278,-1358,-1358}}, +/* CG.AU..AU */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -649,-1628,-1548,-1628,-1628}, +{ -289,-1268,-1188,-1268,-1268}, +{ -739,-1718,-1638,-1718,-1718}, +{ -379,-1358,-1278,-1358,-1358}}}, +/* CG.C@..AU */ +{{{ DEF, -519, -449, -519, -669}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CA..AU */ +{{ DEF, -519, -449, -519, -669}, +{ -479, -948, -878, -948,-1098}, +{ -309, -778, -708, -778, -928}, +{ -389, -858, -788, -858,-1008}, +{ -379, -848, -778, -848, -998}}, +/* CG.CC..AU */ +{{ DEF, -519, -449, -519, -669}, +{ -649,-1118,-1048,-1118,-1268}, +{ -289, -758, -688, -758, -908}, +{ -739,-1208,-1138,-1208,-1358}, +{ -379, -848, -778, -848, -998}}, +/* CG.CG..AU */ +{{ DEF, -519, -449, -519, -669}, +{ -649,-1118,-1048,-1118,-1268}, +{ -289, -758, -688, -758, -908}, +{ -739,-1208,-1138,-1208,-1358}, +{ -379, -848, -778, -848, -998}}, +/* CG.CU..AU */ +{{ DEF, -519, -449, -519, -669}, +{ -649,-1118,-1048,-1118,-1268}, +{ -289, -758, -688, -758, -908}, +{ -739,-1208,-1138,-1208,-1358}, +{ -379, -848, -778, -848, -998}}}, +/* CG.G@..AU */ +{{{ DEF, -939, -939, -939, -939}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GA..AU */ +{{ DEF, -939, -939, -939, -939}, +{ -479,-1368,-1368,-1368,-1368}, +{ -309,-1198,-1198,-1198,-1198}, +{ -389,-1278,-1278,-1278,-1278}, +{ -379,-1268,-1268,-1268,-1268}}, +/* CG.GC..AU */ +{{ DEF, -939, -939, -939, -939}, +{ -649,-1538,-1538,-1538,-1538}, +{ -289,-1178,-1178,-1178,-1178}, +{ -739,-1628,-1628,-1628,-1628}, +{ -379,-1268,-1268,-1268,-1268}}, +/* CG.GG..AU */ +{{ DEF, -939, -939, -939, -939}, +{ -649,-1538,-1538,-1538,-1538}, +{ -289,-1178,-1178,-1178,-1178}, +{ -739,-1628,-1628,-1628,-1628}, +{ -379,-1268,-1268,-1268,-1268}}, +/* CG.GU..AU */ +{{ DEF, -939, -939, -939, -939}, +{ -649,-1538,-1538,-1538,-1538}, +{ -289,-1178,-1178,-1178,-1178}, +{ -739,-1628,-1628,-1628,-1628}, +{ -379,-1268,-1268,-1268,-1268}}}, +/* CG.U@..AU */ +{{{ DEF, -809, -739, -809, -859}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UA..AU */ +{{ DEF, -809, -739, -809, -859}, +{ -479,-1238,-1168,-1238,-1288}, +{ -309,-1068, -998,-1068,-1118}, +{ -389,-1148,-1078,-1148,-1198}, +{ -379,-1138,-1068,-1138,-1188}}, +/* CG.UC..AU */ +{{ DEF, -809, -739, -809, -859}, +{ -649,-1408,-1338,-1408,-1458}, +{ -289,-1048, -978,-1048,-1098}, +{ -739,-1498,-1428,-1498,-1548}, +{ -379,-1138,-1068,-1138,-1188}}, +/* CG.UG..AU */ +{{ DEF, -809, -739, -809, -859}, +{ -649,-1408,-1338,-1408,-1458}, +{ -289,-1048, -978,-1048,-1098}, +{ -739,-1498,-1428,-1498,-1548}, +{ -379,-1138,-1068,-1138,-1188}}, +/* CG.UU..AU */ +{{ DEF, -809, -739, -809, -859}, +{ -649,-1408,-1338,-1408,-1458}, +{ -289,-1048, -978,-1048,-1098}, +{ -739,-1498,-1428,-1498,-1548}, +{ -379,-1138,-1068,-1138,-1188}}}}, +/* CG.@@..UA */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@A..UA */ +{{ 0, 0, 0, 0, 0}, +{ -399, -399, -399, -399, -399}, +{ -429, -429, -429, -429, -429}, +{ -379, -379, -379, -379, -379}, +{ -279, -279, -279, -279, -279}}, +/* CG.@C..UA */ +{{ 0, 0, 0, 0, 0}, +{ -629, -629, -629, -629, -629}, +{ -509, -509, -509, -509, -509}, +{ -679, -679, -679, -679, -679}, +{ -139, -139, -139, -139, -139}}, +/* CG.@G..UA */ +{{ 0, 0, 0, 0, 0}, +{ -889, -889, -889, -889, -889}, +{ -199, -199, -199, -199, -199}, +{ -889, -889, -889, -889, -889}, +{ -279, -279, -279, -279, -279}}, +/* CG.@U..UA */ +{{ 0, 0, 0, 0, 0}, +{ -589, -589, -589, -589, -589}, +{ -179, -179, -179, -179, -179}, +{ -679, -679, -679, -679, -679}, +{ -140, -140, -140, -140, -140}}}, +/* CG.A@..UA */ +{{{ DEF,-1029, -949,-1029,-1029}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AA..UA */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -449,-1428,-1348,-1428,-1428}, +{ -479,-1458,-1378,-1458,-1458}, +{ -429,-1408,-1328,-1408,-1408}, +{ -329,-1308,-1228,-1308,-1308}}, +/* CG.AC..UA */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -679,-1658,-1578,-1658,-1658}, +{ -559,-1538,-1458,-1538,-1538}, +{ -729,-1708,-1628,-1708,-1708}, +{ -189,-1168,-1088,-1168,-1168}}, +/* CG.AG..UA */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -939,-1918,-1838,-1918,-1918}, +{ -249,-1228,-1148,-1228,-1228}, +{ -939,-1918,-1838,-1918,-1918}, +{ -329,-1308,-1228,-1308,-1308}}, +/* CG.AU..UA */ +{{ DEF,-1029, -949,-1029,-1029}, +{ -639,-1618,-1538,-1618,-1618}, +{ -229,-1208,-1128,-1208,-1208}, +{ -729,-1708,-1628,-1708,-1708}, +{ -190,-1169,-1089,-1169,-1169}}}, +/* CG.C@..UA */ +{{{ DEF, -519, -449, -519, -669}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CA..UA */ +{{ DEF, -519, -449, -519, -669}, +{ -449, -918, -848, -918,-1068}, +{ -479, -948, -878, -948,-1098}, +{ -429, -898, -828, -898,-1048}, +{ -329, -798, -728, -798, -948}}, +/* CG.CC..UA */ +{{ DEF, -519, -449, -519, -669}, +{ -679,-1148,-1078,-1148,-1298}, +{ -559,-1028, -958,-1028,-1178}, +{ -729,-1198,-1128,-1198,-1348}, +{ -189, -658, -588, -658, -808}}, +/* CG.CG..UA */ +{{ DEF, -519, -449, -519, -669}, +{ -939,-1408,-1338,-1408,-1558}, +{ -249, -718, -648, -718, -868}, +{ -939,-1408,-1338,-1408,-1558}, +{ -329, -798, -728, -798, -948}}, +/* CG.CU..UA */ +{{ DEF, -519, -449, -519, -669}, +{ -639,-1108,-1038,-1108,-1258}, +{ -229, -698, -628, -698, -848}, +{ -729,-1198,-1128,-1198,-1348}, +{ -190, -659, -589, -659, -809}}}, +/* CG.G@..UA */ +{{{ DEF, -939, -939, -939, -939}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GA..UA */ +{{ DEF, -939, -939, -939, -939}, +{ -449,-1338,-1338,-1338,-1338}, +{ -479,-1368,-1368,-1368,-1368}, +{ -429,-1318,-1318,-1318,-1318}, +{ -329,-1218,-1218,-1218,-1218}}, +/* CG.GC..UA */ +{{ DEF, -939, -939, -939, -939}, +{ -679,-1568,-1568,-1568,-1568}, +{ -559,-1448,-1448,-1448,-1448}, +{ -729,-1618,-1618,-1618,-1618}, +{ -189,-1078,-1078,-1078,-1078}}, +/* CG.GG..UA */ +{{ DEF, -939, -939, -939, -939}, +{ -939,-1828,-1828,-1828,-1828}, +{ -249,-1138,-1138,-1138,-1138}, +{ -939,-1828,-1828,-1828,-1828}, +{ -329,-1218,-1218,-1218,-1218}}, +/* CG.GU..UA */ +{{ DEF, -939, -939, -939, -939}, +{ -639,-1528,-1528,-1528,-1528}, +{ -229,-1118,-1118,-1118,-1118}, +{ -729,-1618,-1618,-1618,-1618}, +{ -190,-1079,-1079,-1079,-1079}}}, +/* CG.U@..UA */ +{{{ DEF, -809, -739, -809, -859}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UA..UA */ +{{ DEF, -809, -739, -809, -859}, +{ -449,-1208,-1138,-1208,-1258}, +{ -479,-1238,-1168,-1238,-1288}, +{ -429,-1188,-1118,-1188,-1238}, +{ -329,-1088,-1018,-1088,-1138}}, +/* CG.UC..UA */ +{{ DEF, -809, -739, -809, -859}, +{ -679,-1438,-1368,-1438,-1488}, +{ -559,-1318,-1248,-1318,-1368}, +{ -729,-1488,-1418,-1488,-1538}, +{ -189, -948, -878, -948, -998}}, +/* CG.UG..UA */ +{{ DEF, -809, -739, -809, -859}, +{ -939,-1698,-1628,-1698,-1748}, +{ -249,-1008, -938,-1008,-1058}, +{ -939,-1698,-1628,-1698,-1748}, +{ -329,-1088,-1018,-1088,-1138}}, +/* CG.UU..UA */ +{{ DEF, -809, -739, -809, -859}, +{ -639,-1398,-1328,-1398,-1448}, +{ -229, -988, -918, -988,-1038}, +{ -729,-1488,-1418,-1488,-1538}, +{ -190, -949, -879, -949, -999}}}}, +/* CG.@@.. @ */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@A.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@C.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@G.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* CG.@U.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}}, +/* CG.A@.. @ */ +{{{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AA.. @ */ +{{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AC.. @ */ +{{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AG.. @ */ +{{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}, +/* CG.AU.. @ */ +{{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}, +{ -100,-1079, -999,-1079,-1079}}}, +/* CG.C@.. @ */ +{{{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CA.. @ */ +{{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CC.. @ */ +{{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CG.. @ */ +{{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}, +/* CG.CU.. @ */ +{{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}, +{ -100, -569, -499, -569, -719}}}, +/* CG.G@.. @ */ +{{{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GA.. @ */ +{{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GC.. @ */ +{{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GG.. @ */ +{{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}, +/* CG.GU.. @ */ +{{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}, +{ -100, -989, -989, -989, -989}}}, +/* CG.U@.. @ */ +{{{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UA.. @ */ +{{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UC.. @ */ +{{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UG.. @ */ +{{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}, +/* CG.UU.. @ */ +{{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}, +{ -100, -859, -789, -859, -909}}}}}, +{ /* noPair */ {{{{0}}}}, +/* GC.@@..CG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@A..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* GC.@C..CG */ +{{ 0, 0, 0, 0, 0}, +{ -949, -949, -949, -949, -949}, +{ -449, -449, -449, -449, -449}, +{ -939, -939, -939, -939, -939}, +{ -739, -739, -739, -739, -739}}, +/* GC.@G..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* GC.@U..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -669, -669, -669, -669, -669}, +{ -939, -939, -939, -939, -939}, +{ -859, -859, -859, -859, -859}}}, +/* GC.A@..CG */ +{{{ DEF, -519, -879, -559, -879}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AA..CG */ +{{ DEF, -519, -879, -559, -879}, +{-1079,-1548,-1908,-1588,-1908}, +{ -569,-1038,-1398,-1078,-1398}, +{ -989,-1458,-1818,-1498,-1818}, +{ -859,-1328,-1688,-1368,-1688}}, +/* GC.AC..CG */ +{{ DEF, -519, -879, -559, -879}, +{ -999,-1468,-1828,-1508,-1828}, +{ -499, -968,-1328,-1008,-1328}, +{ -989,-1458,-1818,-1498,-1818}, +{ -789,-1258,-1618,-1298,-1618}}, +/* GC.AG..CG */ +{{ DEF, -519, -879, -559, -879}, +{-1079,-1548,-1908,-1588,-1908}, +{ -569,-1038,-1398,-1078,-1398}, +{ -989,-1458,-1818,-1498,-1818}, +{ -859,-1328,-1688,-1368,-1688}}, +/* GC.AU..CG */ +{{ DEF, -519, -879, -559, -879}, +{-1079,-1548,-1908,-1588,-1908}, +{ -719,-1188,-1548,-1228,-1548}, +{ -989,-1458,-1818,-1498,-1818}, +{ -909,-1378,-1738,-1418,-1738}}}, +/* GC.C@..CG */ +{{{ DEF, -719, -309, -309, -389}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CA..CG */ +{{ DEF, -719, -309, -309, -389}, +{-1079,-1748,-1338,-1338,-1418}, +{ -569,-1238, -828, -828, -908}, +{ -989,-1658,-1248,-1248,-1328}, +{ -859,-1528,-1118,-1118,-1198}}, +/* GC.CC..CG */ +{{ DEF, -719, -309, -309, -389}, +{ -999,-1668,-1258,-1258,-1338}, +{ -499,-1168, -758, -758, -838}, +{ -989,-1658,-1248,-1248,-1328}, +{ -789,-1458,-1048,-1048,-1128}}, +/* GC.CG..CG */ +{{ DEF, -719, -309, -309, -389}, +{-1079,-1748,-1338,-1338,-1418}, +{ -569,-1238, -828, -828, -908}, +{ -989,-1658,-1248,-1248,-1328}, +{ -859,-1528,-1118,-1118,-1198}}, +/* GC.CU..CG */ +{{ DEF, -719, -309, -309, -389}, +{-1079,-1748,-1338,-1338,-1418}, +{ -719,-1388, -978, -978,-1058}, +{ -989,-1658,-1248,-1248,-1328}, +{ -909,-1578,-1168,-1168,-1248}}}, +/* GC.G@..CG */ +{{{ DEF, -709, -739, -619, -739}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GA..CG */ +{{ DEF, -709, -739, -619, -739}, +{-1079,-1738,-1768,-1648,-1768}, +{ -569,-1228,-1258,-1138,-1258}, +{ -989,-1648,-1678,-1558,-1678}, +{ -859,-1518,-1548,-1428,-1548}}, +/* GC.GC..CG */ +{{ DEF, -709, -739, -619, -739}, +{ -999,-1658,-1688,-1568,-1688}, +{ -499,-1158,-1188,-1068,-1188}, +{ -989,-1648,-1678,-1558,-1678}, +{ -789,-1448,-1478,-1358,-1478}}, +/* GC.GG..CG */ +{{ DEF, -709, -739, -619, -739}, +{-1079,-1738,-1768,-1648,-1768}, +{ -569,-1228,-1258,-1138,-1258}, +{ -989,-1648,-1678,-1558,-1678}, +{ -859,-1518,-1548,-1428,-1548}}, +/* GC.GU..CG */ +{{ DEF, -709, -739, -619, -739}, +{-1079,-1738,-1768,-1648,-1768}, +{ -719,-1378,-1408,-1288,-1408}, +{ -989,-1648,-1678,-1558,-3080}, +{ -909,-1568,-1598,-1478,-1598}}}, +/* GC.U@..CG */ +{{{ DEF, -499, -499, -499, -569}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UA..CG */ +{{ DEF, -499, -499, -499, -569}, +{-1079,-1528,-1528,-1528,-1598}, +{ -569,-1018,-1018,-1018,-1088}, +{ -989,-1438,-1438,-1438,-1508}, +{ -859,-1308,-1308,-1308,-1378}}, +/* GC.UC..CG */ +{{ DEF, -499, -499, -499, -569}, +{ -999,-1448,-1448,-1448,-1518}, +{ -499, -948, -948, -948,-1018}, +{ -989,-1438,-1438,-1438,-1508}, +{ -789,-1238,-1238,-1238,-1308}}, +/* GC.UG..CG */ +{{ DEF, -499, -499, -499, -569}, +{-1079,-1528,-1528,-1528,-1598}, +{ -569,-1018,-1018,-1018,-1088}, +{ -989,-1438,-1438,-1438,-1508}, +{ -859,-1308,-1308,-1308,-1378}}, +/* GC.UU..CG */ +{{ DEF, -499, -499, -499, -569}, +{-1079,-1528,-1528,-1528,-1598}, +{ -719,-1168,-1168,-1168,-1238}, +{ -989,-1438,-1438,-1438,-1508}, +{ -909,-1358,-1358,-1358,-1428}}}}, +/* GC.@@..GC */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@A..GC */ +{{ 0, 0, 0, 0, 0}, +{ -519, -519, -519, -519, -519}, +{ -719, -719, -719, -719, -719}, +{ -709, -709, -709, -709, -709}, +{ -499, -499, -499, -499, -499}}, +/* GC.@C..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -309, -309, -309, -309, -309}, +{ -739, -739, -739, -739, -739}, +{ -499, -499, -499, -499, -499}}, +/* GC.@G..GC */ +{{ 0, 0, 0, 0, 0}, +{ -559, -559, -559, -559, -559}, +{ -309, -309, -309, -309, -309}, +{ -619, -619, -619, -619, -619}, +{ -499, -499, -499, -499, -499}}, +/* GC.@U..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -389, -389, -389, -389, -389}, +{ -739, -739, -739, -739, -739}, +{ -569, -569, -569, -569, -569}}}, +/* GC.A@..GC */ +{{{ DEF, -519, -879, -559, -879}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AA..GC */ +{{ DEF, -519, -879, -559, -879}, +{ -569,-1038,-1398,-1078,-1398}, +{ -769,-1238,-1598,-1278,-1598}, +{ -759,-1228,-1588,-1268,-1588}, +{ -549,-1018,-1378,-1058,-1378}}, +/* GC.AC..GC */ +{{ DEF, -519, -879, -559, -879}, +{ -929,-1398,-1758,-1438,-1758}, +{ -359, -828,-1188, -868,-1188}, +{ -789,-1258,-1618,-1298,-1618}, +{ -549,-1018,-1378,-1058,-1378}}, +/* GC.AG..GC */ +{{ DEF, -519, -879, -559, -879}, +{ -609,-1078,-1438,-1118,-1438}, +{ -359, -828,-1188, -868,-1188}, +{ -669,-1138,-1498,-1178,-1498}, +{ -549,-1018,-1378,-1058,-1378}}, +/* GC.AU..GC */ +{{ DEF, -519, -879, -559, -879}, +{ -929,-1398,-1758,-1438,-1758}, +{ -439, -908,-1268, -948,-1268}, +{ -789,-1258,-1618,-1298,-1618}, +{ -619,-1088,-1448,-1128,-1448}}}, +/* GC.C@..GC */ +{{{ DEF, -719, -309, -309, -389}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CA..GC */ +{{ DEF, -719, -309, -309, -389}, +{ -569,-1238, -828, -828, -908}, +{ -769,-1438,-1028,-1028,-1108}, +{ -759,-1428,-1018,-1018,-1098}, +{ -549,-1218, -808, -808, -888}}, +/* GC.CC..GC */ +{{ DEF, -719, -309, -309, -389}, +{ -929,-1598,-1188,-1188,-1268}, +{ -359,-1028, -618, -618, -698}, +{ -789,-1458,-1048,-1048,-1128}, +{ -549,-1218, -808, -808, -888}}, +/* GC.CG..GC */ +{{ DEF, -719, -309, -309, -389}, +{ -609,-1278, -868, -868, -948}, +{ -359,-1028, -618, -618, -698}, +{ -669,-1338, -928, -928,-1008}, +{ -549,-1218, -808, -808, -888}}, +/* GC.CU..GC */ +{{ DEF, -719, -309, -309, -389}, +{ -929,-1598,-1188,-1188,-1268}, +{ -439,-1108, -698, -698, -778}, +{ -789,-1458,-1048,-1048,-1128}, +{ -619,-1288, -878, -878, -958}}}, +/* GC.G@..GC */ +{{{ DEF, -709, -739, -619, -739}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GA..GC */ +{{ DEF, -709, -739, -619, -739}, +{ -569,-1228,-1258,-1138,-1258}, +{ -769,-1428,-1458,-1338,-1458}, +{ -759,-1418,-1448,-1328,-1448}, +{ -549,-1208,-1238,-1118,-1238}}, +/* GC.GC..GC */ +{{ DEF, -709, -739, -619, -739}, +{ -929,-1588,-1618,-1498,-1618}, +{ -359,-1018,-1048, -928,-1048}, +{ -789,-1448,-1478,-1358,-1478}, +{ -549,-1208,-1238,-1118,-1238}}, +/* GC.GG..GC */ +{{ DEF, -709, -739, -619, -739}, +{ -609,-1268,-1298,-1178,-1298}, +{ -359,-1018,-1048, -928,-1048}, +{ -669,-1328,-1358,-1238,-1358}, +{ -549,-1208,-1238,-1118,-1238}}, +/* GC.GU..GC */ +{{ DEF, -709, -739, -619, -739}, +{ -929,-1588,-1618,-1498,-1618}, +{ -439,-1098,-1128,-1008,-1128}, +{ -789,-1448,-1478,-1358,-3080}, +{ -619,-1278,-1308,-1188,-1308}}}, +/* GC.U@..GC */ +{{{ DEF, -499, -499, -499, -569}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UA..GC */ +{{ DEF, -499, -499, -499, -569}, +{ -569,-1018,-1018,-1018,-1088}, +{ -769,-1218,-1218,-1218,-1288}, +{ -759,-1208,-1208,-1208,-1278}, +{ -549, -998, -998, -998,-1068}}, +/* GC.UC..GC */ +{{ DEF, -499, -499, -499, -569}, +{ -929,-1378,-1378,-1378,-1448}, +{ -359, -808, -808, -808, -878}, +{ -789,-1238,-1238,-1238,-1308}, +{ -549, -998, -998, -998,-1068}}, +/* GC.UG..GC */ +{{ DEF, -499, -499, -499, -569}, +{ -609,-1058,-1058,-1058,-1128}, +{ -359, -808, -808, -808, -878}, +{ -669,-1118,-1118,-1118,-1188}, +{ -549, -998, -998, -998,-1068}}, +/* GC.UU..GC */ +{{ DEF, -499, -499, -499, -569}, +{ -929,-1378,-1378,-1378,-1448}, +{ -439, -888, -888, -888, -958}, +{ -789,-1238,-1238,-1238,-1308}, +{ -619,-1068,-1068,-1068,-1138}}}}, +/* GC.@@..GU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@A..GU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* GC.@C..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GC.@G..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GC.@U..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* GC.A@..GU */ +{{{ DEF, -519, -879, -559, -879}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AA..GU */ +{{ DEF, -519, -879, -559, -879}, +{ -479, -948,-1308, -988,-1308}, +{ -309, -778,-1138, -818,-1138}, +{ -389, -858,-1218, -898,-1218}, +{ -379, -848,-1208, -888,-1208}}, +/* GC.AC..GU */ +{{ DEF, -519, -879, -559, -879}, +{ -649,-1118,-1478,-1158,-1478}, +{ -289, -758,-1118, -798,-1118}, +{ -739,-1208,-1568,-1248,-1568}, +{ -379, -848,-1208, -888,-1208}}, +/* GC.AG..GU */ +{{ DEF, -519, -879, -559, -879}, +{ -649,-1118,-1478,-1158,-1478}, +{ -289, -758,-1118, -798,-1118}, +{ -739,-1208,-1568,-1248,-1568}, +{ -379, -848,-1208, -888,-1208}}, +/* GC.AU..GU */ +{{ DEF, -519, -879, -559, -879}, +{ -649,-1118,-1478,-1158,-1478}, +{ -289, -758,-1118, -798,-1118}, +{ -739,-1208,-1568,-1248,-1568}, +{ -379, -848,-1208, -888,-1208}}}, +/* GC.C@..GU */ +{{{ DEF, -719, -309, -309, -389}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CA..GU */ +{{ DEF, -719, -309, -309, -389}, +{ -479,-1148, -738, -738, -818}, +{ -309, -978, -568, -568, -648}, +{ -389,-1058, -648, -648, -728}, +{ -379,-1048, -638, -638, -718}}, +/* GC.CC..GU */ +{{ DEF, -719, -309, -309, -389}, +{ -649,-1318, -908, -908, -988}, +{ -289, -958, -548, -548, -628}, +{ -739,-1408, -998, -998,-1078}, +{ -379,-1048, -638, -638, -718}}, +/* GC.CG..GU */ +{{ DEF, -719, -309, -309, -389}, +{ -649,-1318, -908, -908, -988}, +{ -289, -958, -548, -548, -628}, +{ -739,-1408, -998, -998,-1078}, +{ -379,-1048, -638, -638, -718}}, +/* GC.CU..GU */ +{{ DEF, -719, -309, -309, -389}, +{ -649,-1318, -908, -908, -988}, +{ -289, -958, -548, -548, -628}, +{ -739,-1408, -998, -998,-1078}, +{ -379,-1048, -638, -638, -718}}}, +/* GC.G@..GU */ +{{{ DEF, -709, -739, -619, -739}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GA..GU */ +{{ DEF, -709, -739, -619, -739}, +{ -479,-1138,-1168,-1048,-1168}, +{ -309, -968, -998, -878, -998}, +{ -389,-1048,-1078, -958,-1078}, +{ -379,-1038,-1068, -948,-1068}}, +/* GC.GC..GU */ +{{ DEF, -709, -739, -619, -739}, +{ -649,-1308,-1338,-1218,-1338}, +{ -289, -948, -978, -858, -978}, +{ -739,-1398,-1428,-1308,-1428}, +{ -379,-1038,-1068, -948,-1068}}, +/* GC.GG..GU */ +{{ DEF, -709, -739, -619, -739}, +{ -649,-1308,-1338,-1218,-1338}, +{ -289, -948, -978, -858, -978}, +{ -739,-1398,-1428,-1308,-1428}, +{ -379,-1038,-1068, -948,-1068}}, +/* GC.GU..GU */ +{{ DEF, -709, -739, -619, -739}, +{ -649,-1308,-1338,-1218,-1338}, +{ -289, -948, -978, -858, -978}, +{ -739,-1398,-1428,-1308,-1428}, +{ -379,-1038,-1068, -948,-1068}}}, +/* GC.U@..GU */ +{{{ DEF, -499, -499, -499, -569}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UA..GU */ +{{ DEF, -499, -499, -499, -569}, +{ -479, -928, -928, -928, -998}, +{ -309, -758, -758, -758, -828}, +{ -389, -838, -838, -838, -908}, +{ -379, -828, -828, -828, -898}}, +/* GC.UC..GU */ +{{ DEF, -499, -499, -499, -569}, +{ -649,-1098,-1098,-1098,-1168}, +{ -289, -738, -738, -738, -808}, +{ -739,-1188,-1188,-1188,-1258}, +{ -379, -828, -828, -828, -898}}, +/* GC.UG..GU */ +{{ DEF, -499, -499, -499, -569}, +{ -649,-1098,-1098,-1098,-1168}, +{ -289, -738, -738, -738, -808}, +{ -739,-1188,-1188,-1188,-1258}, +{ -379, -828, -828, -828, -898}}, +/* GC.UU..GU */ +{{ DEF, -499, -499, -499, -569}, +{ -649,-1098,-1098,-1098,-1168}, +{ -289, -738, -738, -738, -808}, +{ -739,-1188,-1188,-1188,-1258}, +{ -379, -828, -828, -828, -898}}}}, +/* GC.@@..UG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@A..UG */ +{{ 0, 0, 0, 0, 0}, +{ -719, -719, -719, -719, -719}, +{ -479, -479, -479, -479, -479}, +{ -659, -659, -659, -659, -659}, +{ -549, -549, -549, -549, -549}}, +/* GC.@C..UG */ +{{ 0, 0, 0, 0, 0}, +{ -789, -789, -789, -789, -789}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -439, -439, -439, -439, -439}}, +/* GC.@G..UG */ +{{ 0, 0, 0, 0, 0}, +{ -959, -959, -959, -959, -959}, +{ -359, -359, -359, -359, -359}, +{ -919, -919, -919, -919, -919}, +{ -549, -549, -549, -549, -549}}, +/* GC.@U..UG */ +{{ 0, 0, 0, 0, 0}, +{ -809, -809, -809, -809, -809}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -359, -359, -359, -359, -359}}}, +/* GC.A@..UG */ +{{{ DEF, -519, -879, -559, -879}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AA..UG */ +{{ DEF, -519, -879, -559, -879}, +{ -769,-1238,-1598,-1278,-1598}, +{ -529, -998,-1358,-1038,-1358}, +{ -709,-1178,-1538,-1218,-1538}, +{ -599,-1068,-1428,-1108,-1428}}, +/* GC.AC..UG */ +{{ DEF, -519, -879, -559, -879}, +{ -839,-1308,-1668,-1348,-1668}, +{ -529, -998,-1358,-1038,-1358}, +{ -859,-1328,-1688,-1368,-1688}, +{ -489, -958,-1318, -998,-1318}}, +/* GC.AG..UG */ +{{ DEF, -519, -879, -559, -879}, +{-1009,-1478,-1838,-1518,-1838}, +{ -409, -878,-1238, -918,-1238}, +{ -969,-1438,-1798,-1478,-1798}, +{ -599,-1068,-1428,-1108,-1428}}, +/* GC.AU..UG */ +{{ DEF, -519, -879, -559, -879}, +{ -859,-1328,-1688,-1368,-1688}, +{ -529, -998,-1358,-1038,-1358}, +{ -859,-1328,-1688,-1368,-1688}, +{ -409, -878,-1238, -918,-1238}}}, +/* GC.C@..UG */ +{{{ DEF, -719, -309, -309, -389}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CA..UG */ +{{ DEF, -719, -309, -309, -389}, +{ -769,-1438,-1028,-1028,-1108}, +{ -529,-1198, -788, -788, -868}, +{ -709,-1378, -968, -968,-1048}, +{ -599,-1268, -858, -858, -938}}, +/* GC.CC..UG */ +{{ DEF, -719, -309, -309, -389}, +{ -839,-1508,-1098,-1098,-1178}, +{ -529,-1198, -788, -788, -868}, +{ -859,-1528,-1118,-1118,-1198}, +{ -489,-1158, -748, -748, -828}}, +/* GC.CG..UG */ +{{ DEF, -719, -309, -309, -389}, +{-1009,-1678,-1268,-1268,-1348}, +{ -409,-1078, -668, -668, -748}, +{ -969,-1638,-1228,-1228,-1308}, +{ -599,-1268, -858, -858, -938}}, +/* GC.CU..UG */ +{{ DEF, -719, -309, -309, -389}, +{ -859,-1528,-1118,-1118,-1198}, +{ -529,-1198, -788, -788, -868}, +{ -859,-1528,-1118,-1118,-1198}, +{ -409,-1078, -668, -668, -748}}}, +/* GC.G@..UG */ +{{{ DEF, -709, -739, -619, -739}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GA..UG */ +{{ DEF, -709, -739, -619, -739}, +{ -769,-1428,-1458,-1338,-1458}, +{ -529,-1188,-1218,-1098,-1218}, +{ -709,-1368,-1398,-1278,-1398}, +{ -599,-1258,-1288,-1168,-1288}}, +/* GC.GC..UG */ +{{ DEF, -709, -739, -619, -739}, +{ -839,-1498,-1528,-1408,-1528}, +{ -529,-1188,-1218,-1098,-1218}, +{ -859,-1518,-1548,-1428,-1548}, +{ -489,-1148,-1178,-1058,-1178}}, +/* GC.GG..UG */ +{{ DEF, -709, -739, -619, -739}, +{-1009,-1668,-1698,-1578,-1698}, +{ -409,-1068,-1098, -978,-1098}, +{ -969,-1628,-1658,-1538,-1658}, +{ -599,-1258,-1288,-1168,-1288}}, +/* GC.GU..UG */ +{{ DEF, -709, -739, -619, -739}, +{ -859,-1518,-1548,-1428,-1548}, +{ -529,-1188,-1218,-1098,-1218}, +{ -859,-1518,-1548,-1428,-1548}, +{ -409,-1068,-1098, -978,-1098}}}, +/* GC.U@..UG */ +{{{ DEF, -499, -499, -499, -569}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UA..UG */ +{{ DEF, -499, -499, -499, -569}, +{ -769,-1218,-1218,-1218,-1288}, +{ -529, -978, -978, -978,-1048}, +{ -709,-1158,-1158,-1158,-1228}, +{ -599,-1048,-1048,-1048,-1118}}, +/* GC.UC..UG */ +{{ DEF, -499, -499, -499, -569}, +{ -839,-1288,-1288,-1288,-1358}, +{ -529, -978, -978, -978,-1048}, +{ -859,-1308,-1308,-1308,-1378}, +{ -489, -938, -938, -938,-1008}}, +/* GC.UG..UG */ +{{ DEF, -499, -499, -499, -569}, +{-1009,-1458,-1458,-1458,-1528}, +{ -409, -858, -858, -858, -928}, +{ -969,-1418,-1418,-1418,-1488}, +{ -599,-1048,-1048,-1048,-1118}}, +/* GC.UU..UG */ +{{ DEF, -499, -499, -499, -569}, +{ -859,-1308,-1308,-1308,-1378}, +{ -529, -978, -978, -978,-1048}, +{ -859,-1308,-1308,-1308,-1378}, +{ -409, -858, -858, -858, -928}}}}, +/* GC.@@..AU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@A..AU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* GC.@C..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GC.@G..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GC.@U..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* GC.A@..AU */ +{{{ DEF, -519, -879, -559, -879}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AA..AU */ +{{ DEF, -519, -879, -559, -879}, +{ -479, -948,-1308, -988,-1308}, +{ -309, -778,-1138, -818,-1138}, +{ -389, -858,-1218, -898,-1218}, +{ -379, -848,-1208, -888,-1208}}, +/* GC.AC..AU */ +{{ DEF, -519, -879, -559, -879}, +{ -649,-1118,-1478,-1158,-1478}, +{ -289, -758,-1118, -798,-1118}, +{ -739,-1208,-1568,-1248,-1568}, +{ -379, -848,-1208, -888,-1208}}, +/* GC.AG..AU */ +{{ DEF, -519, -879, -559, -879}, +{ -649,-1118,-1478,-1158,-1478}, +{ -289, -758,-1118, -798,-1118}, +{ -739,-1208,-1568,-1248,-1568}, +{ -379, -848,-1208, -888,-1208}}, +/* GC.AU..AU */ +{{ DEF, -519, -879, -559, -879}, +{ -649,-1118,-1478,-1158,-1478}, +{ -289, -758,-1118, -798,-1118}, +{ -739,-1208,-1568,-1248,-1568}, +{ -379, -848,-1208, -888,-1208}}}, +/* GC.C@..AU */ +{{{ DEF, -719, -309, -309, -389}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CA..AU */ +{{ DEF, -719, -309, -309, -389}, +{ -479,-1148, -738, -738, -818}, +{ -309, -978, -568, -568, -648}, +{ -389,-1058, -648, -648, -728}, +{ -379,-1048, -638, -638, -718}}, +/* GC.CC..AU */ +{{ DEF, -719, -309, -309, -389}, +{ -649,-1318, -908, -908, -988}, +{ -289, -958, -548, -548, -628}, +{ -739,-1408, -998, -998,-1078}, +{ -379,-1048, -638, -638, -718}}, +/* GC.CG..AU */ +{{ DEF, -719, -309, -309, -389}, +{ -649,-1318, -908, -908, -988}, +{ -289, -958, -548, -548, -628}, +{ -739,-1408, -998, -998,-1078}, +{ -379,-1048, -638, -638, -718}}, +/* GC.CU..AU */ +{{ DEF, -719, -309, -309, -389}, +{ -649,-1318, -908, -908, -988}, +{ -289, -958, -548, -548, -628}, +{ -739,-1408, -998, -998,-1078}, +{ -379,-1048, -638, -638, -718}}}, +/* GC.G@..AU */ +{{{ DEF, -709, -739, -619, -739}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GA..AU */ +{{ DEF, -709, -739, -619, -739}, +{ -479,-1138,-1168,-1048,-1168}, +{ -309, -968, -998, -878, -998}, +{ -389,-1048,-1078, -958,-1078}, +{ -379,-1038,-1068, -948,-1068}}, +/* GC.GC..AU */ +{{ DEF, -709, -739, -619, -739}, +{ -649,-1308,-1338,-1218,-1338}, +{ -289, -948, -978, -858, -978}, +{ -739,-1398,-1428,-1308,-1428}, +{ -379,-1038,-1068, -948,-1068}}, +/* GC.GG..AU */ +{{ DEF, -709, -739, -619, -739}, +{ -649,-1308,-1338,-1218,-1338}, +{ -289, -948, -978, -858, -978}, +{ -739,-1398,-1428,-1308,-1428}, +{ -379,-1038,-1068, -948,-1068}}, +/* GC.GU..AU */ +{{ DEF, -709, -739, -619, -739}, +{ -649,-1308,-1338,-1218,-1338}, +{ -289, -948, -978, -858, -978}, +{ -739,-1398,-1428,-1308,-1428}, +{ -379,-1038,-1068, -948,-1068}}}, +/* GC.U@..AU */ +{{{ DEF, -499, -499, -499, -569}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UA..AU */ +{{ DEF, -499, -499, -499, -569}, +{ -479, -928, -928, -928, -998}, +{ -309, -758, -758, -758, -828}, +{ -389, -838, -838, -838, -908}, +{ -379, -828, -828, -828, -898}}, +/* GC.UC..AU */ +{{ DEF, -499, -499, -499, -569}, +{ -649,-1098,-1098,-1098,-1168}, +{ -289, -738, -738, -738, -808}, +{ -739,-1188,-1188,-1188,-1258}, +{ -379, -828, -828, -828, -898}}, +/* GC.UG..AU */ +{{ DEF, -499, -499, -499, -569}, +{ -649,-1098,-1098,-1098,-1168}, +{ -289, -738, -738, -738, -808}, +{ -739,-1188,-1188,-1188,-1258}, +{ -379, -828, -828, -828, -898}}, +/* GC.UU..AU */ +{{ DEF, -499, -499, -499, -569}, +{ -649,-1098,-1098,-1098,-1168}, +{ -289, -738, -738, -738, -808}, +{ -739,-1188,-1188,-1188,-1258}, +{ -379, -828, -828, -828, -898}}}}, +/* GC.@@..UA */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@A..UA */ +{{ 0, 0, 0, 0, 0}, +{ -399, -399, -399, -399, -399}, +{ -429, -429, -429, -429, -429}, +{ -379, -379, -379, -379, -379}, +{ -279, -279, -279, -279, -279}}, +/* GC.@C..UA */ +{{ 0, 0, 0, 0, 0}, +{ -629, -629, -629, -629, -629}, +{ -509, -509, -509, -509, -509}, +{ -679, -679, -679, -679, -679}, +{ -139, -139, -139, -139, -139}}, +/* GC.@G..UA */ +{{ 0, 0, 0, 0, 0}, +{ -889, -889, -889, -889, -889}, +{ -199, -199, -199, -199, -199}, +{ -889, -889, -889, -889, -889}, +{ -279, -279, -279, -279, -279}}, +/* GC.@U..UA */ +{{ 0, 0, 0, 0, 0}, +{ -589, -589, -589, -589, -589}, +{ -179, -179, -179, -179, -179}, +{ -679, -679, -679, -679, -679}, +{ -140, -140, -140, -140, -140}}}, +/* GC.A@..UA */ +{{{ DEF, -519, -879, -559, -879}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AA..UA */ +{{ DEF, -519, -879, -559, -879}, +{ -449, -918,-1278, -958,-1278}, +{ -479, -948,-1308, -988,-1308}, +{ -429, -898,-1258, -938,-1258}, +{ -329, -798,-1158, -838,-1158}}, +/* GC.AC..UA */ +{{ DEF, -519, -879, -559, -879}, +{ -679,-1148,-1508,-1188,-1508}, +{ -559,-1028,-1388,-1068,-1388}, +{ -729,-1198,-1558,-1238,-1558}, +{ -189, -658,-1018, -698,-1018}}, +/* GC.AG..UA */ +{{ DEF, -519, -879, -559, -879}, +{ -939,-1408,-1768,-1448,-1768}, +{ -249, -718,-1078, -758,-1078}, +{ -939,-1408,-1768,-1448,-1768}, +{ -329, -798,-1158, -838,-1158}}, +/* GC.AU..UA */ +{{ DEF, -519, -879, -559, -879}, +{ -639,-1108,-1468,-1148,-1468}, +{ -229, -698,-1058, -738,-1058}, +{ -729,-1198,-1558,-1238,-1558}, +{ -190, -659,-1019, -699,-1019}}}, +/* GC.C@..UA */ +{{{ DEF, -719, -309, -309, -389}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CA..UA */ +{{ DEF, -719, -309, -309, -389}, +{ -449,-1118, -708, -708, -788}, +{ -479,-1148, -738, -738, -818}, +{ -429,-1098, -688, -688, -768}, +{ -329, -998, -588, -588, -668}}, +/* GC.CC..UA */ +{{ DEF, -719, -309, -309, -389}, +{ -679,-1348, -938, -938,-1018}, +{ -559,-1228, -818, -818, -898}, +{ -729,-1398, -988, -988,-1068}, +{ -189, -858, -448, -448, -528}}, +/* GC.CG..UA */ +{{ DEF, -719, -309, -309, -389}, +{ -939,-1608,-1198,-1198,-1278}, +{ -249, -918, -508, -508, -588}, +{ -939,-1608,-1198,-1198,-1278}, +{ -329, -998, -588, -588, -668}}, +/* GC.CU..UA */ +{{ DEF, -719, -309, -309, -389}, +{ -639,-1308, -898, -898, -978}, +{ -229, -898, -488, -488, -568}, +{ -729,-1398, -988, -988,-1068}, +{ -190, -859, -449, -449, -529}}}, +/* GC.G@..UA */ +{{{ DEF, -709, -739, -619, -739}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GA..UA */ +{{ DEF, -709, -739, -619, -739}, +{ -449,-1108,-1138,-1018,-1138}, +{ -479,-1138,-1168,-1048,-1168}, +{ -429,-1088,-1118, -998,-1118}, +{ -329, -988,-1018, -898,-1018}}, +/* GC.GC..UA */ +{{ DEF, -709, -739, -619, -739}, +{ -679,-1338,-1368,-1248,-1368}, +{ -559,-1218,-1248,-1128,-1248}, +{ -729,-1388,-1418,-1298,-1418}, +{ -189, -848, -878, -758, -878}}, +/* GC.GG..UA */ +{{ DEF, -709, -739, -619, -739}, +{ -939,-1598,-1628,-1508,-1628}, +{ -249, -908, -938, -818, -938}, +{ -939,-1598,-1628,-1508,-1628}, +{ -329, -988,-1018, -898,-1018}}, +/* GC.GU..UA */ +{{ DEF, -709, -739, -619, -739}, +{ -639,-1298,-1328,-1208,-1328}, +{ -229, -888, -918, -798, -918}, +{ -729,-1388,-1418,-1298,-1418}, +{ -190, -849, -879, -759, -879}}}, +/* GC.U@..UA */ +{{{ DEF, -499, -499, -499, -569}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UA..UA */ +{{ DEF, -499, -499, -499, -569}, +{ -449, -898, -898, -898, -968}, +{ -479, -928, -928, -928, -998}, +{ -429, -878, -878, -878, -948}, +{ -329, -778, -778, -778, -848}}, +/* GC.UC..UA */ +{{ DEF, -499, -499, -499, -569}, +{ -679,-1128,-1128,-1128,-1198}, +{ -559,-1008,-1008,-1008,-1078}, +{ -729,-1178,-1178,-1178,-1248}, +{ -189, -638, -638, -638, -708}}, +/* GC.UG..UA */ +{{ DEF, -499, -499, -499, -569}, +{ -939,-1388,-1388,-1388,-1458}, +{ -249, -698, -698, -698, -768}, +{ -939,-1388,-1388,-1388,-1458}, +{ -329, -778, -778, -778, -848}}, +/* GC.UU..UA */ +{{ DEF, -499, -499, -499, -569}, +{ -639,-1088,-1088,-1088,-1158}, +{ -229, -678, -678, -678, -748}, +{ -729,-1178,-1178,-1178,-1248}, +{ -190, -639, -639, -639, -709}}}}, +/* GC.@@.. @ */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@A.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@C.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@G.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GC.@U.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}}, +/* GC.A@.. @ */ +{{{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AA.. @ */ +{{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AC.. @ */ +{{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AG.. @ */ +{{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}, +/* GC.AU.. @ */ +{{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}, +{ -100, -569, -929, -609, -929}}}, +/* GC.C@.. @ */ +{{{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CA.. @ */ +{{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CC.. @ */ +{{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CG.. @ */ +{{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}, +/* GC.CU.. @ */ +{{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}, +{ -100, -769, -359, -359, -439}}}, +/* GC.G@.. @ */ +{{{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GA.. @ */ +{{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GC.. @ */ +{{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GG.. @ */ +{{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}, +/* GC.GU.. @ */ +{{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}, +{ -100, -759, -789, -669, -789}}}, +/* GC.U@.. @ */ +{{{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UA.. @ */ +{{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UC.. @ */ +{{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UG.. @ */ +{{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}, +/* GC.UU.. @ */ +{{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}, +{ -100, -549, -549, -549, -619}}}}}, +{ /* noPair */ {{{{0}}}}, +/* GU.@@..CG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@A..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* GU.@C..CG */ +{{ 0, 0, 0, 0, 0}, +{ -949, -949, -949, -949, -949}, +{ -449, -449, -449, -449, -449}, +{ -939, -939, -939, -939, -939}, +{ -739, -739, -739, -739, -739}}, +/* GU.@G..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* GU.@U..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -669, -669, -669, -669, -669}, +{ -939, -939, -939, -939, -939}, +{ -859, -859, -859, -859, -859}}}, +/* GU.A@..CG */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AA..CG */ +{{ DEF, -429, -599, -599, -599}, +{-1079,-1458,-1628,-1628,-1628}, +{ -569, -948,-1118,-1118,-1118}, +{ -989,-1368,-1538,-1538,-1538}, +{ -859,-1238,-1408,-1408,-1408}}, +/* GU.AC..CG */ +{{ DEF, -429, -599, -599, -599}, +{ -999,-1378,-1548,-1548,-1548}, +{ -499, -878,-1048,-1048,-1048}, +{ -989,-1368,-1538,-1538,-1538}, +{ -789,-1168,-1338,-1338,-1338}}, +/* GU.AG..CG */ +{{ DEF, -429, -599, -599, -599}, +{-1079,-1458,-1628,-1628,-1628}, +{ -569, -948,-1118,-1118,-1118}, +{ -989,-1368,-1538,-1538,-1538}, +{ -859,-1238,-1408,-1408,-1408}}, +/* GU.AU..CG */ +{{ DEF, -429, -599, -599, -599}, +{-1079,-1458,-1628,-1628,-1628}, +{ -719,-1098,-1268,-1268,-1268}, +{ -989,-1368,-1538,-1538,-1538}, +{ -909,-1288,-1458,-1458,-1458}}}, +/* GU.C@..CG */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CA..CG */ +{{ DEF, -259, -239, -239, -239}, +{-1079,-1288,-1268,-1268,-1268}, +{ -569, -778, -758, -758, -758}, +{ -989,-1198,-1178,-1178,-1178}, +{ -859,-1068,-1048,-1048,-1048}}, +/* GU.CC..CG */ +{{ DEF, -259, -239, -239, -239}, +{ -999,-1208,-1188,-1188,-1188}, +{ -499, -708, -688, -688, -688}, +{ -989,-1198,-1178,-1178,-1178}, +{ -789, -998, -978, -978, -978}}, +/* GU.CG..CG */ +{{ DEF, -259, -239, -239, -239}, +{-1079,-1288,-1268,-1268,-1268}, +{ -569, -778, -758, -758, -758}, +{ -989,-1198,-1178,-1178,-1178}, +{ -859,-1068,-1048,-1048,-1048}}, +/* GU.CU..CG */ +{{ DEF, -259, -239, -239, -239}, +{-1079,-1288,-1268,-1268,-1268}, +{ -719, -928, -908, -908, -908}, +{ -989,-1198,-1178,-1178,-1178}, +{ -909,-1118,-1098,-1098,-1098}}}, +/* GU.G@..CG */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GA..CG */ +{{ DEF, -339, -689, -689, -689}, +{-1079,-1368,-1718,-1718,-1718}, +{ -569, -858,-1208,-1208,-1208}, +{ -989,-1278,-1628,-1628,-1628}, +{ -859,-1148,-1498,-1498,-1498}}, +/* GU.GC..CG */ +{{ DEF, -339, -689, -689, -689}, +{ -999,-1288,-1638,-1638,-1638}, +{ -499, -788,-1138,-1138,-1138}, +{ -989,-1278,-1628,-1628,-1628}, +{ -789,-1078,-1428,-1428,-1428}}, +/* GU.GG..CG */ +{{ DEF, -339, -689, -689, -689}, +{-1079,-1368,-1718,-1718,-1718}, +{ -569, -858,-1208,-1208,-1208}, +{ -989,-1278,-1628,-1628,-1628}, +{ -859,-1148,-1498,-1498,-1498}}, +/* GU.GU..CG */ +{{ DEF, -339, -689, -689, -689}, +{-1079,-1368,-1718,-1718,-1718}, +{ -719,-1008,-1358,-1358,-1358}, +{ -989,-1278,-1628,-1628,-1628}, +{ -909,-1198,-1548,-1548,-1548}}}, +/* GU.U@..CG */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UA..CG */ +{{ DEF, -329, -329, -329, -329}, +{-1079,-1358,-1358,-1358,-1358}, +{ -569, -848, -848, -848, -848}, +{ -989,-1268,-1268,-1268,-1268}, +{ -859,-1138,-1138,-1138,-1138}}, +/* GU.UC..CG */ +{{ DEF, -329, -329, -329, -329}, +{ -999,-1278,-1278,-1278,-1278}, +{ -499, -778, -778, -778, -778}, +{ -989,-1268,-1268,-1268,-1268}, +{ -789,-1068,-1068,-1068,-1068}}, +/* GU.UG..CG */ +{{ DEF, -329, -329, -329, -329}, +{-1079,-1358,-1358,-1358,-1358}, +{ -569, -848, -848, -848, -848}, +{ -989,-1268,-1268,-1268,-1268}, +{ -859,-1138,-1138,-1138,-1138}}, +/* GU.UU..CG */ +{{ DEF, -329, -329, -329, -329}, +{-1079,-1358,-1358,-1358,-1358}, +{ -719, -998, -998, -998, -998}, +{ -989,-1268,-1268,-1268,-1268}, +{ -909,-1188,-1188,-1188,-1188}}}}, +/* GU.@@..GC */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@A..GC */ +{{ 0, 0, 0, 0, 0}, +{ -519, -519, -519, -519, -519}, +{ -719, -719, -719, -719, -719}, +{ -709, -709, -709, -709, -709}, +{ -499, -499, -499, -499, -499}}, +/* GU.@C..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -309, -309, -309, -309, -309}, +{ -739, -739, -739, -739, -739}, +{ -499, -499, -499, -499, -499}}, +/* GU.@G..GC */ +{{ 0, 0, 0, 0, 0}, +{ -559, -559, -559, -559, -559}, +{ -309, -309, -309, -309, -309}, +{ -619, -619, -619, -619, -619}, +{ -499, -499, -499, -499, -499}}, +/* GU.@U..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -389, -389, -389, -389, -389}, +{ -739, -739, -739, -739, -739}, +{ -569, -569, -569, -569, -569}}}, +/* GU.A@..GC */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AA..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -569, -948,-1118,-1118,-1118}, +{ -769,-1148,-1318,-1318,-1318}, +{ -759,-1138,-1308,-1308,-1308}, +{ -549, -928,-1098,-1098,-1098}}, +/* GU.AC..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -929,-1308,-1478,-1478,-1478}, +{ -359, -738, -908, -908, -908}, +{ -789,-1168,-1338,-1338,-1338}, +{ -549, -928,-1098,-1098,-1098}}, +/* GU.AG..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -609, -988,-1158,-1158,-1158}, +{ -359, -738, -908, -908, -908}, +{ -669,-1048,-1218,-1218,-1218}, +{ -549, -928,-1098,-1098,-1098}}, +/* GU.AU..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -929,-1308,-1478,-1478,-1478}, +{ -439, -818, -988, -988, -988}, +{ -789,-1168,-1338,-1338,-1338}, +{ -619, -998,-1168,-1168,-1168}}}, +/* GU.C@..GC */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CA..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -569, -778, -758, -758, -758}, +{ -769, -978, -958, -958, -958}, +{ -759, -968, -948, -948, -948}, +{ -549, -758, -738, -738, -738}}, +/* GU.CC..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -929,-1138,-1118,-1118,-1118}, +{ -359, -568, -548, -548, -548}, +{ -789, -998, -978, -978, -978}, +{ -549, -758, -738, -738, -738}}, +/* GU.CG..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -609, -818, -798, -798, -798}, +{ -359, -568, -548, -548, -548}, +{ -669, -878, -858, -858, -858}, +{ -549, -758, -738, -738, -738}}, +/* GU.CU..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -929,-1138,-1118,-1118,-1118}, +{ -439, -648, -628, -628, -628}, +{ -789, -998, -978, -978, -978}, +{ -619, -828, -808, -808, -808}}}, +/* GU.G@..GC */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GA..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -569, -858,-1208,-1208,-1208}, +{ -769,-1058,-1408,-1408,-1408}, +{ -759,-1048,-1398,-1398,-1398}, +{ -549, -838,-1188,-1188,-1188}}, +/* GU.GC..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -929,-1218,-1568,-1568,-1568}, +{ -359, -648, -998, -998, -998}, +{ -789,-1078,-1428,-1428,-1428}, +{ -549, -838,-1188,-1188,-1188}}, +/* GU.GG..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -609, -898,-1248,-1248,-1248}, +{ -359, -648, -998, -998, -998}, +{ -669, -958,-1308,-1308,-1308}, +{ -549, -838,-1188,-1188,-1188}}, +/* GU.GU..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -929,-1218,-1568,-1568,-1568}, +{ -439, -728,-1078,-1078,-1078}, +{ -789,-1078,-1428,-1428,-1428}, +{ -619, -908,-1258,-1258,-1258}}}, +/* GU.U@..GC */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UA..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -569, -848, -848, -848, -848}, +{ -769,-1048,-1048,-1048,-1048}, +{ -759,-1038,-1038,-1038,-1038}, +{ -549, -828, -828, -828, -828}}, +/* GU.UC..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -929,-1208,-1208,-1208,-1208}, +{ -359, -638, -638, -638, -638}, +{ -789,-1068,-1068,-1068,-1068}, +{ -549, -828, -828, -828, -828}}, +/* GU.UG..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -609, -888, -888, -888, -888}, +{ -359, -638, -638, -638, -638}, +{ -669, -948, -948, -948, -948}, +{ -549, -828, -828, -828, -828}}, +/* GU.UU..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -929,-1208,-1208,-1208,-1208}, +{ -439, -718, -718, -718, -718}, +{ -789,-1068,-1068,-1068,-1068}, +{ -619, -898, -898, -898, -898}}}}, +/* GU.@@..GU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@A..GU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* GU.@C..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GU.@G..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GU.@U..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* GU.A@..GU */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AA..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -479, -858,-1028,-1028,-1028}, +{ -309, -688, -858, -858, -858}, +{ -389, -768, -938, -938, -938}, +{ -379, -758, -928, -928, -928}}, +/* GU.AC..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* GU.AG..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* GU.AU..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}}, +/* GU.C@..GU */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CA..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -479, -688, -668, -668, -668}, +{ -309, -518, -498, -498, -498}, +{ -389, -598, -578, -578, -578}, +{ -379, -588, -568, -568, -568}}, +/* GU.CC..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* GU.CG..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* GU.CU..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}}, +/* GU.G@..GU */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GA..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -479, -768,-1118,-1118,-1118}, +{ -309, -598, -948, -948, -948}, +{ -389, -678,-1028,-1028,-1028}, +{ -379, -668,-1018,-1018,-1018}}, +/* GU.GC..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* GU.GG..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* GU.GU..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}}, +/* GU.U@..GU */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UA..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -479, -758, -758, -758, -758}, +{ -309, -588, -588, -588, -588}, +{ -389, -668, -668, -668, -668}, +{ -379, -658, -658, -658, -658}}, +/* GU.UC..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* GU.UG..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* GU.UU..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}}}, +/* GU.@@..UG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@A..UG */ +{{ 0, 0, 0, 0, 0}, +{ -719, -719, -719, -719, -719}, +{ -479, -479, -479, -479, -479}, +{ -659, -659, -659, -659, -659}, +{ -549, -549, -549, -549, -549}}, +/* GU.@C..UG */ +{{ 0, 0, 0, 0, 0}, +{ -789, -789, -789, -789, -789}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -439, -439, -439, -439, -439}}, +/* GU.@G..UG */ +{{ 0, 0, 0, 0, 0}, +{ -959, -959, -959, -959, -959}, +{ -359, -359, -359, -359, -359}, +{ -919, -919, -919, -919, -919}, +{ -549, -549, -549, -549, -549}}, +/* GU.@U..UG */ +{{ 0, 0, 0, 0, 0}, +{ -809, -809, -809, -809, -809}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -359, -359, -359, -359, -359}}}, +/* GU.A@..UG */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AA..UG */ +{{ DEF, -429, -599, -599, -599}, +{ -769,-1148,-1318,-1318,-1318}, +{ -529, -908,-1078,-1078,-1078}, +{ -709,-1088,-1258,-1258,-1258}, +{ -599, -978,-1148,-1148,-1148}}, +/* GU.AC..UG */ +{{ DEF, -429, -599, -599, -599}, +{ -839,-1218,-1388,-1388,-1388}, +{ -529, -908,-1078,-1078,-1078}, +{ -859,-1238,-1408,-1408,-1408}, +{ -489, -868,-1038,-1038,-1038}}, +/* GU.AG..UG */ +{{ DEF, -429, -599, -599, -599}, +{-1009,-1388,-1558,-1558,-1558}, +{ -409, -788, -958, -958, -958}, +{ -969,-1348,-1518,-1518,-1518}, +{ -599, -978,-1148,-1148,-1148}}, +/* GU.AU..UG */ +{{ DEF, -429, -599, -599, -599}, +{ -859,-1238,-1408,-1408,-1408}, +{ -529, -908,-1078,-1078,-1078}, +{ -859,-1238,-1408,-1408,-1408}, +{ -409, -788, -958, -958, -958}}}, +/* GU.C@..UG */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CA..UG */ +{{ DEF, -259, -239, -239, -239}, +{ -769, -978, -958, -958, -958}, +{ -529, -738, -718, -718, -718}, +{ -709, -918, -898, -898, -898}, +{ -599, -808, -788, -788, -788}}, +/* GU.CC..UG */ +{{ DEF, -259, -239, -239, -239}, +{ -839,-1048,-1028,-1028,-1028}, +{ -529, -738, -718, -718, -718}, +{ -859,-1068,-1048,-1048,-1048}, +{ -489, -698, -678, -678, -678}}, +/* GU.CG..UG */ +{{ DEF, -259, -239, -239, -239}, +{-1009,-1218,-1198,-1198,-1198}, +{ -409, -618, -598, -598, -598}, +{ -969,-1178,-1158,-1158,-1158}, +{ -599, -808, -788, -788, -788}}, +/* GU.CU..UG */ +{{ DEF, -259, -239, -239, -239}, +{ -859,-1068,-1048,-1048,-1048}, +{ -529, -738, -718, -718, -718}, +{ -859,-1068,-1048,-1048,-1048}, +{ -409, -618, -598, -598, -598}}}, +/* GU.G@..UG */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GA..UG */ +{{ DEF, -339, -689, -689, -689}, +{ -769,-1058,-1408,-1408,-1408}, +{ -529, -818,-1168,-1168,-1168}, +{ -709, -998,-1348,-1348,-1348}, +{ -599, -888,-1238,-1238,-1238}}, +/* GU.GC..UG */ +{{ DEF, -339, -689, -689, -689}, +{ -839,-1128,-1478,-1478,-1478}, +{ -529, -818,-1168,-1168,-1168}, +{ -859,-1148,-1498,-1498,-1498}, +{ -489, -778,-1128,-1128,-1128}}, +/* GU.GG..UG */ +{{ DEF, -339, -689, -689, -689}, +{-1009,-1298,-1648,-1648,-1648}, +{ -409, -698,-1048,-1048,-1048}, +{ -969,-1258,-1608,-1608,-1608}, +{ -599, -888,-1238,-1238,-1238}}, +/* GU.GU..UG */ +{{ DEF, -339, -689, -689, -689}, +{ -859,-1148,-1498,-1498,-1498}, +{ -529, -818,-1168,-1168,-1168}, +{ -859,-1148,-1498,-1498,-1498}, +{ -409, -698,-1048,-1048,-1048}}}, +/* GU.U@..UG */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UA..UG */ +{{ DEF, -329, -329, -329, -329}, +{ -769,-1048,-1048,-1048,-1048}, +{ -529, -808, -808, -808, -808}, +{ -709, -988, -988, -988, -988}, +{ -599, -878, -878, -878, -878}}, +/* GU.UC..UG */ +{{ DEF, -329, -329, -329, -329}, +{ -839,-1118,-1118,-1118,-1118}, +{ -529, -808, -808, -808, -808}, +{ -859,-1138,-1138,-1138,-1138}, +{ -489, -768, -768, -768, -768}}, +/* GU.UG..UG */ +{{ DEF, -329, -329, -329, -329}, +{-1009,-1288,-1288,-1288,-1288}, +{ -409, -688, -688, -688, -688}, +{ -969,-1248,-1248,-1248,-1248}, +{ -599, -878, -878, -878, -878}}, +/* GU.UU..UG */ +{{ DEF, -329, -329, -329, -329}, +{ -859,-1138,-1138,-1138,-1138}, +{ -529, -808, -808, -808, -808}, +{ -859,-1138,-1138,-1138,-1138}, +{ -409, -688, -688, -688, -688}}}}, +/* GU.@@..AU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@A..AU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* GU.@C..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GU.@G..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* GU.@U..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* GU.A@..AU */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AA..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -479, -858,-1028,-1028,-1028}, +{ -309, -688, -858, -858, -858}, +{ -389, -768, -938, -938, -938}, +{ -379, -758, -928, -928, -928}}, +/* GU.AC..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* GU.AG..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* GU.AU..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}}, +/* GU.C@..AU */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CA..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -479, -688, -668, -668, -668}, +{ -309, -518, -498, -498, -498}, +{ -389, -598, -578, -578, -578}, +{ -379, -588, -568, -568, -568}}, +/* GU.CC..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* GU.CG..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* GU.CU..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}}, +/* GU.G@..AU */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GA..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -479, -768,-1118,-1118,-1118}, +{ -309, -598, -948, -948, -948}, +{ -389, -678,-1028,-1028,-1028}, +{ -379, -668,-1018,-1018,-1018}}, +/* GU.GC..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* GU.GG..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* GU.GU..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}}, +/* GU.U@..AU */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UA..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -479, -758, -758, -758, -758}, +{ -309, -588, -588, -588, -588}, +{ -389, -668, -668, -668, -668}, +{ -379, -658, -658, -658, -658}}, +/* GU.UC..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* GU.UG..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* GU.UU..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}}}, +/* GU.@@..UA */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@A..UA */ +{{ 0, 0, 0, 0, 0}, +{ -399, -399, -399, -399, -399}, +{ -429, -429, -429, -429, -429}, +{ -379, -379, -379, -379, -379}, +{ -279, -279, -279, -279, -279}}, +/* GU.@C..UA */ +{{ 0, 0, 0, 0, 0}, +{ -629, -629, -629, -629, -629}, +{ -509, -509, -509, -509, -509}, +{ -679, -679, -679, -679, -679}, +{ -139, -139, -139, -139, -139}}, +/* GU.@G..UA */ +{{ 0, 0, 0, 0, 0}, +{ -889, -889, -889, -889, -889}, +{ -199, -199, -199, -199, -199}, +{ -889, -889, -889, -889, -889}, +{ -279, -279, -279, -279, -279}}, +/* GU.@U..UA */ +{{ 0, 0, 0, 0, 0}, +{ -589, -589, -589, -589, -589}, +{ -179, -179, -179, -179, -179}, +{ -679, -679, -679, -679, -679}, +{ -140, -140, -140, -140, -140}}}, +/* GU.A@..UA */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AA..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -449, -828, -998, -998, -998}, +{ -479, -858,-1028,-1028,-1028}, +{ -429, -808, -978, -978, -978}, +{ -329, -708, -878, -878, -878}}, +/* GU.AC..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -679,-1058,-1228,-1228,-1228}, +{ -559, -938,-1108,-1108,-1108}, +{ -729,-1108,-1278,-1278,-1278}, +{ -189, -568, -738, -738, -738}}, +/* GU.AG..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -939,-1318,-1488,-1488,-1488}, +{ -249, -628, -798, -798, -798}, +{ -939,-1318,-1488,-1488,-1488}, +{ -329, -708, -878, -878, -878}}, +/* GU.AU..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -639,-1018,-1188,-1188,-1188}, +{ -229, -608, -778, -778, -778}, +{ -729,-1108,-1278,-1278,-1278}, +{ -190, -569, -739, -739, -739}}}, +/* GU.C@..UA */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CA..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -449, -658, -638, -638, -638}, +{ -479, -688, -668, -668, -668}, +{ -429, -638, -618, -618, -618}, +{ -329, -538, -518, -518, -518}}, +/* GU.CC..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -679, -888, -868, -868, -868}, +{ -559, -768, -748, -748, -748}, +{ -729, -938, -918, -918, -918}, +{ -189, -398, -378, -378, -378}}, +/* GU.CG..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -939,-1148,-1128,-1128,-1128}, +{ -249, -458, -438, -438, -438}, +{ -939,-1148,-1128,-1128,-1128}, +{ -329, -538, -518, -518, -518}}, +/* GU.CU..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -639, -848, -828, -828, -828}, +{ -229, -438, -418, -418, -418}, +{ -729, -938, -918, -918, -918}, +{ -190, -399, -379, -379, -379}}}, +/* GU.G@..UA */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GA..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -449, -738,-1088,-1088,-1088}, +{ -479, -768,-1118,-1118,-1118}, +{ -429, -718,-1068,-1068,-1068}, +{ -329, -618, -968, -968, -968}}, +/* GU.GC..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -679, -968,-1318,-1318,-1318}, +{ -559, -848,-1198,-1198,-1198}, +{ -729,-1018,-1368,-1368,-1368}, +{ -189, -478, -828, -828, -828}}, +/* GU.GG..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -939,-1228,-1578,-1578,-1578}, +{ -249, -538, -888, -888, -888}, +{ -939,-1228,-1578,-1578,-1578}, +{ -329, -618, -968, -968, -968}}, +/* GU.GU..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -639, -928,-1278,-1278,-1278}, +{ -229, -518, -868, -868, -868}, +{ -729,-1018,-1368,-1368,-1368}, +{ -190, -479, -829, -829, -829}}}, +/* GU.U@..UA */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UA..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -449, -728, -728, -728, -728}, +{ -479, -758, -758, -758, -758}, +{ -429, -708, -708, -708, -708}, +{ -329, -608, -608, -608, -608}}, +/* GU.UC..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -679, -958, -958, -958, -958}, +{ -559, -838, -838, -838, -838}, +{ -729,-1008,-1008,-1008,-1008}, +{ -189, -468, -468, -468, -468}}, +/* GU.UG..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -939,-1218,-1218,-1218,-1218}, +{ -249, -528, -528, -528, -528}, +{ -939,-1218,-1218,-1218,-1218}, +{ -329, -608, -608, -608, -608}}, +/* GU.UU..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -639, -918, -918, -918, -918}, +{ -229, -508, -508, -508, -508}, +{ -729,-1008,-1008,-1008,-1008}, +{ -190, -469, -469, -469, -469}}}}, +/* GU.@@.. @ */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@A.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@C.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@G.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* GU.@U.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}}, +/* GU.A@.. @ */ +{{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AA.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AC.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AG.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* GU.AU.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}}, +/* GU.C@.. @ */ +{{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CA.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CC.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CG.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* GU.CU.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}}, +/* GU.G@.. @ */ +{{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GA.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GC.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GG.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* GU.GU.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}}, +/* GU.U@.. @ */ +{{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UA.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UC.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UG.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* GU.UU.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}}}}, +{ /* noPair */ {{{{0}}}}, +/* UG.@@..CG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@A..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* UG.@C..CG */ +{{ 0, 0, 0, 0, 0}, +{ -949, -949, -949, -949, -949}, +{ -449, -449, -449, -449, -449}, +{ -939, -939, -939, -939, -939}, +{ -739, -739, -739, -739, -739}}, +/* UG.@G..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* UG.@U..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -669, -669, -669, -669, -669}, +{ -939, -939, -939, -939, -939}, +{ -859, -859, -859, -859, -859}}}, +/* UG.A@..CG */ +{{{ DEF, -719, -789, -959, -809}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AA..CG */ +{{ DEF, -719, -789, -959, -809}, +{-1079,-1748,-1818,-1988,-1838}, +{ -569,-1238,-1308,-1478,-1328}, +{ -989,-1658,-1728,-1898,-1748}, +{ -859,-1528,-1598,-1768,-1618}}, +/* UG.AC..CG */ +{{ DEF, -719, -789, -959, -809}, +{ -999,-1668,-1738,-1908,-1758}, +{ -499,-1168,-1238,-1408,-1258}, +{ -989,-1658,-1728,-1898,-1748}, +{ -789,-1458,-1528,-1698,-1548}}, +/* UG.AG..CG */ +{{ DEF, -719, -789, -959, -809}, +{-1079,-1748,-1818,-1988,-1838}, +{ -569,-1238,-1308,-1478,-1328}, +{ -989,-1658,-1728,-1898,-1748}, +{ -859,-1528,-1598,-1768,-1618}}, +/* UG.AU..CG */ +{{ DEF, -719, -789, -959, -809}, +{-1079,-1748,-1818,-1988,-1838}, +{ -719,-1388,-1458,-1628,-1478}, +{ -989,-1658,-1728,-1898,-1748}, +{ -909,-1578,-1648,-1818,-1668}}}, +/* UG.C@..CG */ +{{{ DEF, -479, -479, -359, -479}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CA..CG */ +{{ DEF, -479, -479, -359, -479}, +{-1079,-1508,-1508,-1388,-1508}, +{ -569, -998, -998, -878, -998}, +{ -989,-1418,-1418,-1298,-1418}, +{ -859,-1288,-1288,-1168,-1288}}, +/* UG.CC..CG */ +{{ DEF, -479, -479, -359, -479}, +{ -999,-1428,-1428,-1308,-1428}, +{ -499, -928, -928, -808, -928}, +{ -989,-1418,-1418,-1298,-1418}, +{ -789,-1218,-1218,-1098,-1218}}, +/* UG.CG..CG */ +{{ DEF, -479, -479, -359, -479}, +{-1079,-1508,-1508,-1388,-1508}, +{ -569, -998, -998, -878, -998}, +{ -989,-1418,-1418,-1298,-1418}, +{ -859,-1288,-1288,-1168,-1288}}, +/* UG.CU..CG */ +{{ DEF, -479, -479, -359, -479}, +{-1079,-1508,-1508,-1388,-1508}, +{ -719,-1148,-1148,-1028,-1148}, +{ -989,-1418,-1418,-1298,-1418}, +{ -909,-1338,-1338,-1218,-1338}}}, +/* UG.G@..CG */ +{{{ DEF, -659, -809, -919, -809}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GA..CG */ +{{ DEF, -659, -809, -919, -809}, +{-1079,-1688,-1838,-1948,-1838}, +{ -569,-1178,-1328,-1438,-1328}, +{ -989,-1598,-1748,-1858,-1748}, +{ -859,-1468,-1618,-1728,-1618}}, +/* UG.GC..CG */ +{{ DEF, -659, -809, -919, -809}, +{ -999,-1608,-1758,-1868,-1758}, +{ -499,-1108,-1258,-1368,-1258}, +{ -989,-1598,-1748,-1858,-1748}, +{ -789,-1398,-1548,-1658,-1548}}, +/* UG.GG..CG */ +{{ DEF, -659, -809, -919, -809}, +{-1079,-1688,-1838,-1948,-1838}, +{ -569,-1178,-1328,-1438,-1328}, +{ -989,-1598,-1748,-1858,-1748}, +{ -859,-1468,-1618,-1728,-1618}}, +/* UG.GU..CG */ +{{ DEF, -659, -809, -919, -809}, +{-1079,-1688,-1838,-1948,-1838}, +{ -719,-1328,-1478,-1588,-1478}, +{ -989,-1598,-1748,-1858,-1748}, +{ -909,-1518,-1668,-1778,-1668}}}, +/* UG.U@..CG */ +{{{ DEF, -549, -439, -549, -359}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UA..CG */ +{{ DEF, -549, -439, -549, -359}, +{-1079,-1578,-1468,-1578,-1388}, +{ -569,-1068, -958,-1068, -878}, +{ -989,-1488,-1378,-1488,-1298}, +{ -859,-1358,-1248,-1358,-1168}}, +/* UG.UC..CG */ +{{ DEF, -549, -439, -549, -359}, +{ -999,-1498,-1388,-1498,-1308}, +{ -499, -998, -888, -998, -808}, +{ -989,-1488,-1378,-1488,-1298}, +{ -789,-1288,-1178,-1288,-1098}}, +/* UG.UG..CG */ +{{ DEF, -549, -439, -549, -359}, +{-1079,-1578,-1468,-1578,-1388}, +{ -569,-1068, -958,-1068, -878}, +{ -989,-1488,-1378,-1488,-1298}, +{ -859,-1358,-1248,-1358,-1168}}, +/* UG.UU..CG */ +{{ DEF, -549, -439, -549, -359}, +{-1079,-1578,-1468,-1578,-1388}, +{ -719,-1218,-1108,-1218,-1028}, +{ -989,-1488,-1378,-1488,-1298}, +{ -909,-1408,-1298,-1408,-1218}}}}, +/* UG.@@..GC */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@A..GC */ +{{ 0, 0, 0, 0, 0}, +{ -519, -519, -519, -519, -519}, +{ -719, -719, -719, -719, -719}, +{ -709, -709, -709, -709, -709}, +{ -499, -499, -499, -499, -499}}, +/* UG.@C..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -309, -309, -309, -309, -309}, +{ -739, -739, -739, -739, -739}, +{ -499, -499, -499, -499, -499}}, +/* UG.@G..GC */ +{{ 0, 0, 0, 0, 0}, +{ -559, -559, -559, -559, -559}, +{ -309, -309, -309, -309, -309}, +{ -619, -619, -619, -619, -619}, +{ -499, -499, -499, -499, -499}}, +/* UG.@U..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -389, -389, -389, -389, -389}, +{ -739, -739, -739, -739, -739}, +{ -569, -569, -569, -569, -569}}}, +/* UG.A@..GC */ +{{{ DEF, -719, -789, -959, -809}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AA..GC */ +{{ DEF, -719, -789, -959, -809}, +{ -569,-1238,-1308,-1478,-1328}, +{ -769,-1438,-1508,-1678,-1528}, +{ -759,-1428,-1498,-1668,-1518}, +{ -549,-1218,-1288,-1458,-1308}}, +/* UG.AC..GC */ +{{ DEF, -719, -789, -959, -809}, +{ -929,-1598,-1668,-1838,-1688}, +{ -359,-1028,-1098,-1268,-1118}, +{ -789,-1458,-1528,-1698,-1548}, +{ -549,-1218,-1288,-1458,-1308}}, +/* UG.AG..GC */ +{{ DEF, -719, -789, -959, -809}, +{ -609,-1278,-1348,-1518,-1368}, +{ -359,-1028,-1098,-1268,-1118}, +{ -669,-1338,-1408,-1578,-1428}, +{ -549,-1218,-1288,-1458,-1308}}, +/* UG.AU..GC */ +{{ DEF, -719, -789, -959, -809}, +{ -929,-1598,-1668,-1838,-1688}, +{ -439,-1108,-1178,-1348,-1198}, +{ -789,-1458,-1528,-1698,-1548}, +{ -619,-1288,-1358,-1528,-1378}}}, +/* UG.C@..GC */ +{{{ DEF, -479, -479, -359, -479}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CA..GC */ +{{ DEF, -479, -479, -359, -479}, +{ -569, -998, -998, -878, -998}, +{ -769,-1198,-1198,-1078,-1198}, +{ -759,-1188,-1188,-1068,-1188}, +{ -549, -978, -978, -858, -978}}, +/* UG.CC..GC */ +{{ DEF, -479, -479, -359, -479}, +{ -929,-1358,-1358,-1238,-1358}, +{ -359, -788, -788, -668, -788}, +{ -789,-1218,-1218,-1098,-1218}, +{ -549, -978, -978, -858, -978}}, +/* UG.CG..GC */ +{{ DEF, -479, -479, -359, -479}, +{ -609,-1038,-1038, -918,-1038}, +{ -359, -788, -788, -668, -788}, +{ -669,-1098,-1098, -978,-1098}, +{ -549, -978, -978, -858, -978}}, +/* UG.CU..GC */ +{{ DEF, -479, -479, -359, -479}, +{ -929,-1358,-1358,-1238,-1358}, +{ -439, -868, -868, -748, -868}, +{ -789,-1218,-1218,-1098,-1218}, +{ -619,-1048,-1048, -928,-1048}}}, +/* UG.G@..GC */ +{{{ DEF, -659, -809, -919, -809}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GA..GC */ +{{ DEF, -659, -809, -919, -809}, +{ -569,-1178,-1328,-1438,-1328}, +{ -769,-1378,-1528,-1638,-1528}, +{ -759,-1368,-1518,-1628,-1518}, +{ -549,-1158,-1308,-1418,-1308}}, +/* UG.GC..GC */ +{{ DEF, -659, -809, -919, -809}, +{ -929,-1538,-1688,-1798,-1688}, +{ -359, -968,-1118,-1228,-1118}, +{ -789,-1398,-1548,-1658,-1548}, +{ -549,-1158,-1308,-1418,-1308}}, +/* UG.GG..GC */ +{{ DEF, -659, -809, -919, -809}, +{ -609,-1218,-1368,-1478,-1368}, +{ -359, -968,-1118,-1228,-1118}, +{ -669,-1278,-1428,-1538,-1428}, +{ -549,-1158,-1308,-1418,-1308}}, +/* UG.GU..GC */ +{{ DEF, -659, -809, -919, -809}, +{ -929,-1538,-1688,-1798,-1688}, +{ -439,-1048,-1198,-1308,-1198}, +{ -789,-1398,-1548,-1658,-1548}, +{ -619,-1228,-1378,-1488,-1378}}}, +/* UG.U@..GC */ +{{{ DEF, -549, -439, -549, -359}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UA..GC */ +{{ DEF, -549, -439, -549, -359}, +{ -569,-1068, -958,-1068, -878}, +{ -769,-1268,-1158,-1268,-1078}, +{ -759,-1258,-1148,-1258,-1068}, +{ -549,-1048, -938,-1048, -858}}, +/* UG.UC..GC */ +{{ DEF, -549, -439, -549, -359}, +{ -929,-1428,-1318,-1428,-1238}, +{ -359, -858, -748, -858, -668}, +{ -789,-1288,-1178,-1288,-1098}, +{ -549,-1048, -938,-1048, -858}}, +/* UG.UG..GC */ +{{ DEF, -549, -439, -549, -359}, +{ -609,-1108, -998,-1108, -918}, +{ -359, -858, -748, -858, -668}, +{ -669,-1168,-1058,-1168, -978}, +{ -549,-1048, -938,-1048, -858}}, +/* UG.UU..GC */ +{{ DEF, -549, -439, -549, -359}, +{ -929,-1428,-1318,-1428,-1238}, +{ -439, -938, -828, -938, -748}, +{ -789,-1288,-1178,-1288,-1098}, +{ -619,-1118,-1008,-1118, -928}}}}, +/* UG.@@..GU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@A..GU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* UG.@C..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UG.@G..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UG.@U..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* UG.A@..GU */ +{{{ DEF, -719, -789, -959, -809}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AA..GU */ +{{ DEF, -719, -789, -959, -809}, +{ -479,-1148,-1218,-1388,-1238}, +{ -309, -978,-1048,-1218,-1068}, +{ -389,-1058,-1128,-1298,-1148}, +{ -379,-1048,-1118,-1288,-1138}}, +/* UG.AC..GU */ +{{ DEF, -719, -789, -959, -809}, +{ -649,-1318,-1388,-1558,-1408}, +{ -289, -958,-1028,-1198,-1048}, +{ -739,-1408,-1478,-1648,-1498}, +{ -379,-1048,-1118,-1288,-1138}}, +/* UG.AG..GU */ +{{ DEF, -719, -789, -959, -809}, +{ -649,-1318,-1388,-1558,-1408}, +{ -289, -958,-1028,-1198,-1048}, +{ -739,-1408,-1478,-1648,-1498}, +{ -379,-1048,-1118,-1288,-1138}}, +/* UG.AU..GU */ +{{ DEF, -719, -789, -959, -809}, +{ -649,-1318,-1388,-1558,-1408}, +{ -289, -958,-1028,-1198,-1048}, +{ -739,-1408,-1478,-1648,-1498}, +{ -379,-1048,-1118,-1288,-1138}}}, +/* UG.C@..GU */ +{{{ DEF, -479, -479, -359, -479}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CA..GU */ +{{ DEF, -479, -479, -359, -479}, +{ -479, -908, -908, -788, -908}, +{ -309, -738, -738, -618, -738}, +{ -389, -818, -818, -698, -818}, +{ -379, -808, -808, -688, -808}}, +/* UG.CC..GU */ +{{ DEF, -479, -479, -359, -479}, +{ -649,-1078,-1078, -958,-1078}, +{ -289, -718, -718, -598, -718}, +{ -739,-1168,-1168,-1048,-1168}, +{ -379, -808, -808, -688, -808}}, +/* UG.CG..GU */ +{{ DEF, -479, -479, -359, -479}, +{ -649,-1078,-1078, -958,-1078}, +{ -289, -718, -718, -598, -718}, +{ -739,-1168,-1168,-1048,-1168}, +{ -379, -808, -808, -688, -808}}, +/* UG.CU..GU */ +{{ DEF, -479, -479, -359, -479}, +{ -649,-1078,-1078, -958,-1078}, +{ -289, -718, -718, -598, -718}, +{ -739,-1168,-1168,-1048,-1168}, +{ -379, -808, -808, -688, -808}}}, +/* UG.G@..GU */ +{{{ DEF, -659, -809, -919, -809}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GA..GU */ +{{ DEF, -659, -809, -919, -809}, +{ -479,-1088,-1238,-1348,-1238}, +{ -309, -918,-1068,-1178,-1068}, +{ -389, -998,-1148,-1258,-1148}, +{ -379, -988,-1138,-1248,-1138}}, +/* UG.GC..GU */ +{{ DEF, -659, -809, -919, -809}, +{ -649,-1258,-1408,-1518,-1408}, +{ -289, -898,-1048,-1158,-1048}, +{ -739,-1348,-1498,-1608,-1498}, +{ -379, -988,-1138,-1248,-1138}}, +/* UG.GG..GU */ +{{ DEF, -659, -809, -919, -809}, +{ -649,-1258,-1408,-1518,-1408}, +{ -289, -898,-1048,-1158,-1048}, +{ -739,-1348,-1498,-1608,-1498}, +{ -379, -988,-1138,-1248,-1138}}, +/* UG.GU..GU */ +{{ DEF, -659, -809, -919, -809}, +{ -649,-1258,-1408,-1518,-1408}, +{ -289, -898,-1048,-1158,-1048}, +{ -739,-1348,-1498,-1608,-1498}, +{ -379, -988,-1138,-1248,-1138}}}, +/* UG.U@..GU */ +{{{ DEF, -549, -439, -549, -359}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UA..GU */ +{{ DEF, -549, -439, -549, -359}, +{ -479, -978, -868, -978, -788}, +{ -309, -808, -698, -808, -618}, +{ -389, -888, -778, -888, -698}, +{ -379, -878, -768, -878, -688}}, +/* UG.UC..GU */ +{{ DEF, -549, -439, -549, -359}, +{ -649,-1148,-1038,-1148, -958}, +{ -289, -788, -678, -788, -598}, +{ -739,-1238,-1128,-1238,-1048}, +{ -379, -878, -768, -878, -688}}, +/* UG.UG..GU */ +{{ DEF, -549, -439, -549, -359}, +{ -649,-1148,-1038,-1148, -958}, +{ -289, -788, -678, -788, -598}, +{ -739,-1238,-1128,-1238,-1048}, +{ -379, -878, -768, -878, -688}}, +/* UG.UU..GU */ +{{ DEF, -549, -439, -549, -359}, +{ -649,-1148,-1038,-1148, -958}, +{ -289, -788, -678, -788, -598}, +{ -739,-1238,-1128,-1238,-1048}, +{ -379, -878, -768, -878, -688}}}}, +/* UG.@@..UG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@A..UG */ +{{ 0, 0, 0, 0, 0}, +{ -719, -719, -719, -719, -719}, +{ -479, -479, -479, -479, -479}, +{ -659, -659, -659, -659, -659}, +{ -549, -549, -549, -549, -549}}, +/* UG.@C..UG */ +{{ 0, 0, 0, 0, 0}, +{ -789, -789, -789, -789, -789}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -439, -439, -439, -439, -439}}, +/* UG.@G..UG */ +{{ 0, 0, 0, 0, 0}, +{ -959, -959, -959, -959, -959}, +{ -359, -359, -359, -359, -359}, +{ -919, -919, -919, -919, -919}, +{ -549, -549, -549, -549, -549}}, +/* UG.@U..UG */ +{{ 0, 0, 0, 0, 0}, +{ -809, -809, -809, -809, -809}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -359, -359, -359, -359, -359}}}, +/* UG.A@..UG */ +{{{ DEF, -719, -789, -959, -809}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AA..UG */ +{{ DEF, -719, -789, -959, -809}, +{ -769,-1438,-1508,-1678,-1528}, +{ -529,-1198,-1268,-1438,-1288}, +{ -709,-1378,-1448,-1618,-1468}, +{ -599,-1268,-1338,-1508,-1358}}, +/* UG.AC..UG */ +{{ DEF, -719, -789, -959, -809}, +{ -839,-1508,-1578,-1748,-1598}, +{ -529,-1198,-1268,-1438,-1288}, +{ -859,-1528,-1598,-1768,-1618}, +{ -489,-1158,-1228,-1398,-1248}}, +/* UG.AG..UG */ +{{ DEF, -719, -789, -959, -809}, +{-1009,-1678,-1748,-1918,-1768}, +{ -409,-1078,-1148,-1318,-1168}, +{ -969,-1638,-1708,-1878,-1728}, +{ -599,-1268,-1338,-1508,-1358}}, +/* UG.AU..UG */ +{{ DEF, -719, -789, -959, -809}, +{ -859,-1528,-1598,-1768,-1618}, +{ -529,-1198,-1268,-1438,-1288}, +{ -859,-1528,-1598,-1768,-1618}, +{ -409,-1078,-1148,-1318,-1168}}}, +/* UG.C@..UG */ +{{{ DEF, -479, -479, -359, -479}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CA..UG */ +{{ DEF, -479, -479, -359, -479}, +{ -769,-1198,-1198,-1078,-1198}, +{ -529, -958, -958, -838, -958}, +{ -709,-1138,-1138,-1018,-1138}, +{ -599,-1028,-1028, -908,-1028}}, +/* UG.CC..UG */ +{{ DEF, -479, -479, -359, -479}, +{ -839,-1268,-1268,-1148,-1268}, +{ -529, -958, -958, -838, -958}, +{ -859,-1288,-1288,-1168,-1288}, +{ -489, -918, -918, -798, -918}}, +/* UG.CG..UG */ +{{ DEF, -479, -479, -359, -479}, +{-1009,-1438,-1438,-1318,-1438}, +{ -409, -838, -838, -718, -838}, +{ -969,-1398,-1398,-1278,-1398}, +{ -599,-1028,-1028, -908,-1028}}, +/* UG.CU..UG */ +{{ DEF, -479, -479, -359, -479}, +{ -859,-1288,-1288,-1168,-1288}, +{ -529, -958, -958, -838, -958}, +{ -859,-1288,-1288,-1168,-1288}, +{ -409, -838, -838, -718, -838}}}, +/* UG.G@..UG */ +{{{ DEF, -659, -809, -919, -809}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GA..UG */ +{{ DEF, -659, -809, -919, -809}, +{ -769,-1378,-1528,-1638,-1528}, +{ -529,-1138,-1288,-1398,-1288}, +{ -709,-1318,-1468,-1578,-1468}, +{ -599,-1208,-1358,-1468,-1358}}, +/* UG.GC..UG */ +{{ DEF, -659, -809, -919, -809}, +{ -839,-1448,-1598,-1708,-1598}, +{ -529,-1138,-1288,-1398,-1288}, +{ -859,-1468,-1618,-1728,-1618}, +{ -489,-1098,-1248,-1358,-1248}}, +/* UG.GG..UG */ +{{ DEF, -659, -809, -919, -809}, +{-1009,-1618,-1768,-1878,-1768}, +{ -409,-1018,-1168,-1278,-1168}, +{ -969,-1578,-1728,-1838,-1728}, +{ -599,-1208,-1358,-1468,-1358}}, +/* UG.GU..UG */ +{{ DEF, -659, -809, -919, -809}, +{ -859,-1468,-1618,-1728,-1618}, +{ -529,-1138,-1288,-1398,-1288}, +{ -859,-1468,-1618,-1728,-1618}, +{ -409,-1018,-1168,-1278,-1168}}}, +/* UG.U@..UG */ +{{{ DEF, -549, -439, -549, -359}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UA..UG */ +{{ DEF, -549, -439, -549, -359}, +{ -769,-1268,-1158,-1268,-1078}, +{ -529,-1028, -918,-1028, -838}, +{ -709,-1208,-1098,-1208,-1018}, +{ -599,-1098, -988,-1098, -908}}, +/* UG.UC..UG */ +{{ DEF, -549, -439, -549, -359}, +{ -839,-1338,-1228,-1338,-1148}, +{ -529,-1028, -918,-1028, -838}, +{ -859,-1358,-1248,-1358,-1168}, +{ -489, -988, -878, -988, -798}}, +/* UG.UG..UG */ +{{ DEF, -549, -439, -549, -359}, +{-1009,-1508,-1398,-1508,-1318}, +{ -409, -908, -798, -908, -718}, +{ -969,-1468,-1358,-1468,-1278}, +{ -599,-1098, -988,-1098, -908}}, +/* UG.UU..UG */ +{{ DEF, -549, -439, -549, -359}, +{ -859,-1358,-1248,-1358,-1168}, +{ -529,-1028, -918,-1028, -838}, +{ -859,-1358,-1248,-1358,-1168}, +{ -409, -908, -798, -908, -718}}}}, +/* UG.@@..AU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@A..AU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* UG.@C..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UG.@G..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UG.@U..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* UG.A@..AU */ +{{{ DEF, -719, -789, -959, -809}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AA..AU */ +{{ DEF, -719, -789, -959, -809}, +{ -479,-1148,-1218,-1388,-1238}, +{ -309, -978,-1048,-1218,-1068}, +{ -389,-1058,-1128,-1298,-1148}, +{ -379,-1048,-1118,-1288,-1138}}, +/* UG.AC..AU */ +{{ DEF, -719, -789, -959, -809}, +{ -649,-1318,-1388,-1558,-1408}, +{ -289, -958,-1028,-1198,-1048}, +{ -739,-1408,-1478,-1648,-1498}, +{ -379,-1048,-1118,-1288,-1138}}, +/* UG.AG..AU */ +{{ DEF, -719, -789, -959, -809}, +{ -649,-1318,-1388,-1558,-1408}, +{ -289, -958,-1028,-1198,-1048}, +{ -739,-1408,-1478,-1648,-1498}, +{ -379,-1048,-1118,-1288,-1138}}, +/* UG.AU..AU */ +{{ DEF, -719, -789, -959, -809}, +{ -649,-1318,-1388,-1558,-1408}, +{ -289, -958,-1028,-1198,-1048}, +{ -739,-1408,-1478,-1648,-1498}, +{ -379,-1048,-1118,-1288,-1138}}}, +/* UG.C@..AU */ +{{{ DEF, -479, -479, -359, -479}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CA..AU */ +{{ DEF, -479, -479, -359, -479}, +{ -479, -908, -908, -788, -908}, +{ -309, -738, -738, -618, -738}, +{ -389, -818, -818, -698, -818}, +{ -379, -808, -808, -688, -808}}, +/* UG.CC..AU */ +{{ DEF, -479, -479, -359, -479}, +{ -649,-1078,-1078, -958,-1078}, +{ -289, -718, -718, -598, -718}, +{ -739,-1168,-1168,-1048,-1168}, +{ -379, -808, -808, -688, -808}}, +/* UG.CG..AU */ +{{ DEF, -479, -479, -359, -479}, +{ -649,-1078,-1078, -958,-1078}, +{ -289, -718, -718, -598, -718}, +{ -739,-1168,-1168,-1048,-1168}, +{ -379, -808, -808, -688, -808}}, +/* UG.CU..AU */ +{{ DEF, -479, -479, -359, -479}, +{ -649,-1078,-1078, -958,-1078}, +{ -289, -718, -718, -598, -718}, +{ -739,-1168,-1168,-1048,-1168}, +{ -379, -808, -808, -688, -808}}}, +/* UG.G@..AU */ +{{{ DEF, -659, -809, -919, -809}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GA..AU */ +{{ DEF, -659, -809, -919, -809}, +{ -479,-1088,-1238,-1348,-1238}, +{ -309, -918,-1068,-1178,-1068}, +{ -389, -998,-1148,-1258,-1148}, +{ -379, -988,-1138,-1248,-1138}}, +/* UG.GC..AU */ +{{ DEF, -659, -809, -919, -809}, +{ -649,-1258,-1408,-1518,-1408}, +{ -289, -898,-1048,-1158,-1048}, +{ -739,-1348,-1498,-1608,-1498}, +{ -379, -988,-1138,-1248,-1138}}, +/* UG.GG..AU */ +{{ DEF, -659, -809, -919, -809}, +{ -649,-1258,-1408,-1518,-1408}, +{ -289, -898,-1048,-1158,-1048}, +{ -739,-1348,-1498,-1608,-1498}, +{ -379, -988,-1138,-1248,-1138}}, +/* UG.GU..AU */ +{{ DEF, -659, -809, -919, -809}, +{ -649,-1258,-1408,-1518,-1408}, +{ -289, -898,-1048,-1158,-1048}, +{ -739,-1348,-1498,-1608,-1498}, +{ -379, -988,-1138,-1248,-1138}}}, +/* UG.U@..AU */ +{{{ DEF, -549, -439, -549, -359}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UA..AU */ +{{ DEF, -549, -439, -549, -359}, +{ -479, -978, -868, -978, -788}, +{ -309, -808, -698, -808, -618}, +{ -389, -888, -778, -888, -698}, +{ -379, -878, -768, -878, -688}}, +/* UG.UC..AU */ +{{ DEF, -549, -439, -549, -359}, +{ -649,-1148,-1038,-1148, -958}, +{ -289, -788, -678, -788, -598}, +{ -739,-1238,-1128,-1238,-1048}, +{ -379, -878, -768, -878, -688}}, +/* UG.UG..AU */ +{{ DEF, -549, -439, -549, -359}, +{ -649,-1148,-1038,-1148, -958}, +{ -289, -788, -678, -788, -598}, +{ -739,-1238,-1128,-1238,-1048}, +{ -379, -878, -768, -878, -688}}, +/* UG.UU..AU */ +{{ DEF, -549, -439, -549, -359}, +{ -649,-1148,-1038,-1148, -958}, +{ -289, -788, -678, -788, -598}, +{ -739,-1238,-1128,-1238,-1048}, +{ -379, -878, -768, -878, -688}}}}, +/* UG.@@..UA */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@A..UA */ +{{ 0, 0, 0, 0, 0}, +{ -399, -399, -399, -399, -399}, +{ -429, -429, -429, -429, -429}, +{ -379, -379, -379, -379, -379}, +{ -279, -279, -279, -279, -279}}, +/* UG.@C..UA */ +{{ 0, 0, 0, 0, 0}, +{ -629, -629, -629, -629, -629}, +{ -509, -509, -509, -509, -509}, +{ -679, -679, -679, -679, -679}, +{ -139, -139, -139, -139, -139}}, +/* UG.@G..UA */ +{{ 0, 0, 0, 0, 0}, +{ -889, -889, -889, -889, -889}, +{ -199, -199, -199, -199, -199}, +{ -889, -889, -889, -889, -889}, +{ -279, -279, -279, -279, -279}}, +/* UG.@U..UA */ +{{ 0, 0, 0, 0, 0}, +{ -589, -589, -589, -589, -589}, +{ -179, -179, -179, -179, -179}, +{ -679, -679, -679, -679, -679}, +{ -140, -140, -140, -140, -140}}}, +/* UG.A@..UA */ +{{{ DEF, -719, -789, -959, -809}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AA..UA */ +{{ DEF, -719, -789, -959, -809}, +{ -449,-1118,-1188,-1358,-1208}, +{ -479,-1148,-1218,-1388,-1238}, +{ -429,-1098,-1168,-1338,-1188}, +{ -329, -998,-1068,-1238,-1088}}, +/* UG.AC..UA */ +{{ DEF, -719, -789, -959, -809}, +{ -679,-1348,-1418,-1588,-1438}, +{ -559,-1228,-1298,-1468,-1318}, +{ -729,-1398,-1468,-1638,-1488}, +{ -189, -858, -928,-1098, -948}}, +/* UG.AG..UA */ +{{ DEF, -719, -789, -959, -809}, +{ -939,-1608,-1678,-1848,-1698}, +{ -249, -918, -988,-1158,-1008}, +{ -939,-1608,-1678,-1848,-1698}, +{ -329, -998,-1068,-1238,-1088}}, +/* UG.AU..UA */ +{{ DEF, -719, -789, -959, -809}, +{ -639,-1308,-1378,-1548,-1398}, +{ -229, -898, -968,-1138, -988}, +{ -729,-1398,-1468,-1638,-1488}, +{ -190, -859, -929,-1099, -949}}}, +/* UG.C@..UA */ +{{{ DEF, -479, -479, -359, -479}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CA..UA */ +{{ DEF, -479, -479, -359, -479}, +{ -449, -878, -878, -758, -878}, +{ -479, -908, -908, -788, -908}, +{ -429, -858, -858, -738, -858}, +{ -329, -758, -758, -638, -758}}, +/* UG.CC..UA */ +{{ DEF, -479, -479, -359, -479}, +{ -679,-1108,-1108, -988,-1108}, +{ -559, -988, -988, -868, -988}, +{ -729,-1158,-1158,-1038,-1158}, +{ -189, -618, -618, -498, -618}}, +/* UG.CG..UA */ +{{ DEF, -479, -479, -359, -479}, +{ -939,-1368,-1368,-1248,-1368}, +{ -249, -678, -678, -558, -678}, +{ -939,-1368,-1368,-1248,-1368}, +{ -329, -758, -758, -638, -758}}, +/* UG.CU..UA */ +{{ DEF, -479, -479, -359, -479}, +{ -639,-1068,-1068, -948,-1068}, +{ -229, -658, -658, -538, -658}, +{ -729,-1158,-1158,-1038,-1158}, +{ -190, -619, -619, -499, -619}}}, +/* UG.G@..UA */ +{{{ DEF, -659, -809, -919, -809}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GA..UA */ +{{ DEF, -659, -809, -919, -809}, +{ -449,-1058,-1208,-1318,-1208}, +{ -479,-1088,-1238,-1348,-1238}, +{ -429,-1038,-1188,-1298,-1188}, +{ -329, -938,-1088,-1198,-1088}}, +/* UG.GC..UA */ +{{ DEF, -659, -809, -919, -809}, +{ -679,-1288,-1438,-1548,-1438}, +{ -559,-1168,-1318,-1428,-1318}, +{ -729,-1338,-1488,-1598,-1488}, +{ -189, -798, -948,-1058, -948}}, +/* UG.GG..UA */ +{{ DEF, -659, -809, -919, -809}, +{ -939,-1548,-1698,-1808,-1698}, +{ -249, -858,-1008,-1118,-1008}, +{ -939,-1548,-1698,-1808,-1698}, +{ -329, -938,-1088,-1198,-1088}}, +/* UG.GU..UA */ +{{ DEF, -659, -809, -919, -809}, +{ -639,-1248,-1398,-1508,-1398}, +{ -229, -838, -988,-1098, -988}, +{ -729,-1338,-1488,-1598,-1488}, +{ -190, -799, -949,-1059, -949}}}, +/* UG.U@..UA */ +{{{ DEF, -549, -439, -549, -359}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UA..UA */ +{{ DEF, -549, -439, -549, -359}, +{ -449, -948, -838, -948, -758}, +{ -479, -978, -868, -978, -788}, +{ -429, -928, -818, -928, -738}, +{ -329, -828, -718, -828, -638}}, +/* UG.UC..UA */ +{{ DEF, -549, -439, -549, -359}, +{ -679,-1178,-1068,-1178, -988}, +{ -559,-1058, -948,-1058, -868}, +{ -729,-1228,-1118,-1228,-1038}, +{ -189, -688, -578, -688, -498}}, +/* UG.UG..UA */ +{{ DEF, -549, -439, -549, -359}, +{ -939,-1438,-1328,-1438,-1248}, +{ -249, -748, -638, -748, -558}, +{ -939,-1438,-1328,-1438,-1248}, +{ -329, -828, -718, -828, -638}}, +/* UG.UU..UA */ +{{ DEF, -549, -439, -549, -359}, +{ -639,-1138,-1028,-1138, -948}, +{ -229, -728, -618, -728, -538}, +{ -729,-1228,-1118,-1228,-1038}, +{ -190, -689, -579, -689, -499}}}}, +/* UG.@@.. @ */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@A.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@C.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@G.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UG.@U.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}}, +/* UG.A@.. @ */ +{{{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AA.. @ */ +{{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AC.. @ */ +{{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AG.. @ */ +{{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}, +/* UG.AU.. @ */ +{{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}, +{ -100, -769, -839,-1009, -859}}}, +/* UG.C@.. @ */ +{{{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CA.. @ */ +{{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CC.. @ */ +{{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CG.. @ */ +{{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}, +/* UG.CU.. @ */ +{{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}, +{ -100, -529, -529, -409, -529}}}, +/* UG.G@.. @ */ +{{{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GA.. @ */ +{{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GC.. @ */ +{{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GG.. @ */ +{{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}, +/* UG.GU.. @ */ +{{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}, +{ -100, -709, -859, -969, -859}}}, +/* UG.U@.. @ */ +{{{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UA.. @ */ +{{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UC.. @ */ +{{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UG.. @ */ +{{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}, +/* UG.UU.. @ */ +{{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}, +{ -100, -599, -489, -599, -409}}}}}, +{ /* noPair */ {{{{0}}}}, +/* AU.@@..CG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@A..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* AU.@C..CG */ +{{ 0, 0, 0, 0, 0}, +{ -949, -949, -949, -949, -949}, +{ -449, -449, -449, -449, -449}, +{ -939, -939, -939, -939, -939}, +{ -739, -739, -739, -739, -739}}, +/* AU.@G..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* AU.@U..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -669, -669, -669, -669, -669}, +{ -939, -939, -939, -939, -939}, +{ -859, -859, -859, -859, -859}}}, +/* AU.A@..CG */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AA..CG */ +{{ DEF, -429, -599, -599, -599}, +{-1079,-1458,-1628,-1628,-1628}, +{ -569, -948,-1118,-1118,-1118}, +{ -989,-1368,-1538,-1538,-1538}, +{ -859,-1238,-1408,-1408,-1408}}, +/* AU.AC..CG */ +{{ DEF, -429, -599, -599, -599}, +{ -999,-1378,-1548,-1548,-1548}, +{ -499, -878,-1048,-1048,-1048}, +{ -989,-1368,-1538,-1538,-1538}, +{ -789,-1168,-1338,-1338,-1338}}, +/* AU.AG..CG */ +{{ DEF, -429, -599, -599, -599}, +{-1079,-1458,-1628,-1628,-1628}, +{ -569, -948,-1118,-1118,-1118}, +{ -989,-1368,-1538,-1538,-1538}, +{ -859,-1238,-1408,-1408,-1408}}, +/* AU.AU..CG */ +{{ DEF, -429, -599, -599, -599}, +{-1079,-1458,-1628,-1628,-1628}, +{ -719,-1098,-1268,-1268,-1268}, +{ -989,-1368,-1538,-1538,-1538}, +{ -909,-1288,-1458,-1458,-1458}}}, +/* AU.C@..CG */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CA..CG */ +{{ DEF, -259, -239, -239, -239}, +{-1079,-1288,-1268,-1268,-1268}, +{ -569, -778, -758, -758, -758}, +{ -989,-1198,-1178,-1178,-1178}, +{ -859,-1068,-1048,-1048,-1048}}, +/* AU.CC..CG */ +{{ DEF, -259, -239, -239, -239}, +{ -999,-1208,-1188,-1188,-1188}, +{ -499, -708, -688, -688, -688}, +{ -989,-1198,-1178,-1178,-1178}, +{ -789, -998, -978, -978, -978}}, +/* AU.CG..CG */ +{{ DEF, -259, -239, -239, -239}, +{-1079,-1288,-1268,-1268,-1268}, +{ -569, -778, -758, -758, -758}, +{ -989,-1198,-1178,-1178,-1178}, +{ -859,-1068,-1048,-1048,-1048}}, +/* AU.CU..CG */ +{{ DEF, -259, -239, -239, -239}, +{-1079,-1288,-1268,-1268,-1268}, +{ -719, -928, -908, -908, -908}, +{ -989,-1198,-1178,-1178,-1178}, +{ -909,-1118,-1098,-1098,-1098}}}, +/* AU.G@..CG */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GA..CG */ +{{ DEF, -339, -689, -689, -689}, +{-1079,-1368,-1718,-1718,-1718}, +{ -569, -858,-1208,-1208,-1208}, +{ -989,-1278,-1628,-1628,-1628}, +{ -859,-1148,-1498,-1498,-1498}}, +/* AU.GC..CG */ +{{ DEF, -339, -689, -689, -689}, +{ -999,-1288,-1638,-1638,-1638}, +{ -499, -788,-1138,-1138,-1138}, +{ -989,-1278,-1628,-1628,-1628}, +{ -789,-1078,-1428,-1428,-1428}}, +/* AU.GG..CG */ +{{ DEF, -339, -689, -689, -689}, +{-1079,-1368,-1718,-1718,-1718}, +{ -569, -858,-1208,-1208,-1208}, +{ -989,-1278,-1628,-1628,-1628}, +{ -859,-1148,-1498,-1498,-1498}}, +/* AU.GU..CG */ +{{ DEF, -339, -689, -689, -689}, +{-1079,-1368,-1718,-1718,-1718}, +{ -719,-1008,-1358,-1358,-1358}, +{ -989,-1278,-1628,-1628,-1628}, +{ -909,-1198,-1548,-1548,-1548}}}, +/* AU.U@..CG */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UA..CG */ +{{ DEF, -329, -329, -329, -329}, +{-1079,-1358,-1358,-1358,-1358}, +{ -569, -848, -848, -848, -848}, +{ -989,-1268,-1268,-1268,-1268}, +{ -859,-1138,-1138,-1138,-1138}}, +/* AU.UC..CG */ +{{ DEF, -329, -329, -329, -329}, +{ -999,-1278,-1278,-1278,-1278}, +{ -499, -778, -778, -778, -778}, +{ -989,-1268,-1268,-1268,-1268}, +{ -789,-1068,-1068,-1068,-1068}}, +/* AU.UG..CG */ +{{ DEF, -329, -329, -329, -329}, +{-1079,-1358,-1358,-1358,-1358}, +{ -569, -848, -848, -848, -848}, +{ -989,-1268,-1268,-1268,-1268}, +{ -859,-1138,-1138,-1138,-1138}}, +/* AU.UU..CG */ +{{ DEF, -329, -329, -329, -329}, +{-1079,-1358,-1358,-1358,-1358}, +{ -719, -998, -998, -998, -998}, +{ -989,-1268,-1268,-1268,-1268}, +{ -909,-1188,-1188,-1188,-1188}}}}, +/* AU.@@..GC */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@A..GC */ +{{ 0, 0, 0, 0, 0}, +{ -519, -519, -519, -519, -519}, +{ -719, -719, -719, -719, -719}, +{ -709, -709, -709, -709, -709}, +{ -499, -499, -499, -499, -499}}, +/* AU.@C..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -309, -309, -309, -309, -309}, +{ -739, -739, -739, -739, -739}, +{ -499, -499, -499, -499, -499}}, +/* AU.@G..GC */ +{{ 0, 0, 0, 0, 0}, +{ -559, -559, -559, -559, -559}, +{ -309, -309, -309, -309, -309}, +{ -619, -619, -619, -619, -619}, +{ -499, -499, -499, -499, -499}}, +/* AU.@U..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -389, -389, -389, -389, -389}, +{ -739, -739, -739, -739, -739}, +{ -569, -569, -569, -569, -569}}}, +/* AU.A@..GC */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AA..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -569, -948,-1118,-1118,-1118}, +{ -769,-1148,-1318,-1318,-1318}, +{ -759,-1138,-1308,-1308,-1308}, +{ -549, -928,-1098,-1098,-1098}}, +/* AU.AC..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -929,-1308,-1478,-1478,-1478}, +{ -359, -738, -908, -908, -908}, +{ -789,-1168,-1338,-1338,-1338}, +{ -549, -928,-1098,-1098,-1098}}, +/* AU.AG..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -609, -988,-1158,-1158,-1158}, +{ -359, -738, -908, -908, -908}, +{ -669,-1048,-1218,-1218,-1218}, +{ -549, -928,-1098,-1098,-1098}}, +/* AU.AU..GC */ +{{ DEF, -429, -599, -599, -599}, +{ -929,-1308,-1478,-1478,-1478}, +{ -439, -818, -988, -988, -988}, +{ -789,-1168,-1338,-1338,-1338}, +{ -619, -998,-1168,-1168,-1168}}}, +/* AU.C@..GC */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CA..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -569, -778, -758, -758, -758}, +{ -769, -978, -958, -958, -958}, +{ -759, -968, -948, -948, -948}, +{ -549, -758, -738, -738, -738}}, +/* AU.CC..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -929,-1138,-1118,-1118,-1118}, +{ -359, -568, -548, -548, -548}, +{ -789, -998, -978, -978, -978}, +{ -549, -758, -738, -738, -738}}, +/* AU.CG..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -609, -818, -798, -798, -798}, +{ -359, -568, -548, -548, -548}, +{ -669, -878, -858, -858, -858}, +{ -549, -758, -738, -738, -738}}, +/* AU.CU..GC */ +{{ DEF, -259, -239, -239, -239}, +{ -929,-1138,-1118,-1118,-1118}, +{ -439, -648, -628, -628, -628}, +{ -789, -998, -978, -978, -978}, +{ -619, -828, -808, -808, -808}}}, +/* AU.G@..GC */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GA..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -569, -858,-1208,-1208,-1208}, +{ -769,-1058,-1408,-1408,-1408}, +{ -759,-1048,-1398,-1398,-1398}, +{ -549, -838,-1188,-1188,-1188}}, +/* AU.GC..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -929,-1218,-1568,-1568,-1568}, +{ -359, -648, -998, -998, -998}, +{ -789,-1078,-1428,-1428,-1428}, +{ -549, -838,-1188,-1188,-1188}}, +/* AU.GG..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -609, -898,-1248,-1248,-1248}, +{ -359, -648, -998, -998, -998}, +{ -669, -958,-1308,-1308,-1308}, +{ -549, -838,-1188,-1188,-1188}}, +/* AU.GU..GC */ +{{ DEF, -339, -689, -689, -689}, +{ -929,-1218,-1568,-1568,-1568}, +{ -439, -728,-1078,-1078,-1078}, +{ -789,-1078,-1428,-1428,-1428}, +{ -619, -908,-1258,-1258,-1258}}}, +/* AU.U@..GC */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UA..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -569, -848, -848, -848, -848}, +{ -769,-1048,-1048,-1048,-1048}, +{ -759,-1038,-1038,-1038,-1038}, +{ -549, -828, -828, -828, -828}}, +/* AU.UC..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -929,-1208,-1208,-1208,-1208}, +{ -359, -638, -638, -638, -638}, +{ -789,-1068,-1068,-1068,-1068}, +{ -549, -828, -828, -828, -828}}, +/* AU.UG..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -609, -888, -888, -888, -888}, +{ -359, -638, -638, -638, -638}, +{ -669, -948, -948, -948, -948}, +{ -549, -828, -828, -828, -828}}, +/* AU.UU..GC */ +{{ DEF, -329, -329, -329, -329}, +{ -929,-1208,-1208,-1208,-1208}, +{ -439, -718, -718, -718, -718}, +{ -789,-1068,-1068,-1068,-1068}, +{ -619, -898, -898, -898, -898}}}}, +/* AU.@@..GU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@A..GU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* AU.@C..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* AU.@G..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* AU.@U..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* AU.A@..GU */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AA..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -479, -858,-1028,-1028,-1028}, +{ -309, -688, -858, -858, -858}, +{ -389, -768, -938, -938, -938}, +{ -379, -758, -928, -928, -928}}, +/* AU.AC..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* AU.AG..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* AU.AU..GU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}}, +/* AU.C@..GU */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CA..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -479, -688, -668, -668, -668}, +{ -309, -518, -498, -498, -498}, +{ -389, -598, -578, -578, -578}, +{ -379, -588, -568, -568, -568}}, +/* AU.CC..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* AU.CG..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* AU.CU..GU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}}, +/* AU.G@..GU */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GA..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -479, -768,-1118,-1118,-1118}, +{ -309, -598, -948, -948, -948}, +{ -389, -678,-1028,-1028,-1028}, +{ -379, -668,-1018,-1018,-1018}}, +/* AU.GC..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* AU.GG..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* AU.GU..GU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}}, +/* AU.U@..GU */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UA..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -479, -758, -758, -758, -758}, +{ -309, -588, -588, -588, -588}, +{ -389, -668, -668, -668, -668}, +{ -379, -658, -658, -658, -658}}, +/* AU.UC..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* AU.UG..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* AU.UU..GU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}}}, +/* AU.@@..UG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@A..UG */ +{{ 0, 0, 0, 0, 0}, +{ -719, -719, -719, -719, -719}, +{ -479, -479, -479, -479, -479}, +{ -659, -659, -659, -659, -659}, +{ -549, -549, -549, -549, -549}}, +/* AU.@C..UG */ +{{ 0, 0, 0, 0, 0}, +{ -789, -789, -789, -789, -789}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -439, -439, -439, -439, -439}}, +/* AU.@G..UG */ +{{ 0, 0, 0, 0, 0}, +{ -959, -959, -959, -959, -959}, +{ -359, -359, -359, -359, -359}, +{ -919, -919, -919, -919, -919}, +{ -549, -549, -549, -549, -549}}, +/* AU.@U..UG */ +{{ 0, 0, 0, 0, 0}, +{ -809, -809, -809, -809, -809}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -359, -359, -359, -359, -359}}}, +/* AU.A@..UG */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AA..UG */ +{{ DEF, -429, -599, -599, -599}, +{ -769,-1148,-1318,-1318,-1318}, +{ -529, -908,-1078,-1078,-1078}, +{ -709,-1088,-1258,-1258,-1258}, +{ -599, -978,-1148,-1148,-1148}}, +/* AU.AC..UG */ +{{ DEF, -429, -599, -599, -599}, +{ -839,-1218,-1388,-1388,-1388}, +{ -529, -908,-1078,-1078,-1078}, +{ -859,-1238,-1408,-1408,-1408}, +{ -489, -868,-1038,-1038,-1038}}, +/* AU.AG..UG */ +{{ DEF, -429, -599, -599, -599}, +{-1009,-1388,-1558,-1558,-1558}, +{ -409, -788, -958, -958, -958}, +{ -969,-1348,-1518,-1518,-1518}, +{ -599, -978,-1148,-1148,-1148}}, +/* AU.AU..UG */ +{{ DEF, -429, -599, -599, -599}, +{ -859,-1238,-1408,-1408,-1408}, +{ -529, -908,-1078,-1078,-1078}, +{ -859,-1238,-1408,-1408,-1408}, +{ -409, -788, -958, -958, -958}}}, +/* AU.C@..UG */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CA..UG */ +{{ DEF, -259, -239, -239, -239}, +{ -769, -978, -958, -958, -958}, +{ -529, -738, -718, -718, -718}, +{ -709, -918, -898, -898, -898}, +{ -599, -808, -788, -788, -788}}, +/* AU.CC..UG */ +{{ DEF, -259, -239, -239, -239}, +{ -839,-1048,-1028,-1028,-1028}, +{ -529, -738, -718, -718, -718}, +{ -859,-1068,-1048,-1048,-1048}, +{ -489, -698, -678, -678, -678}}, +/* AU.CG..UG */ +{{ DEF, -259, -239, -239, -239}, +{-1009,-1218,-1198,-1198,-1198}, +{ -409, -618, -598, -598, -598}, +{ -969,-1178,-1158,-1158,-1158}, +{ -599, -808, -788, -788, -788}}, +/* AU.CU..UG */ +{{ DEF, -259, -239, -239, -239}, +{ -859,-1068,-1048,-1048,-1048}, +{ -529, -738, -718, -718, -718}, +{ -859,-1068,-1048,-1048,-1048}, +{ -409, -618, -598, -598, -598}}}, +/* AU.G@..UG */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GA..UG */ +{{ DEF, -339, -689, -689, -689}, +{ -769,-1058,-1408,-1408,-1408}, +{ -529, -818,-1168,-1168,-1168}, +{ -709, -998,-1348,-1348,-1348}, +{ -599, -888,-1238,-1238,-1238}}, +/* AU.GC..UG */ +{{ DEF, -339, -689, -689, -689}, +{ -839,-1128,-1478,-1478,-1478}, +{ -529, -818,-1168,-1168,-1168}, +{ -859,-1148,-1498,-1498,-1498}, +{ -489, -778,-1128,-1128,-1128}}, +/* AU.GG..UG */ +{{ DEF, -339, -689, -689, -689}, +{-1009,-1298,-1648,-1648,-1648}, +{ -409, -698,-1048,-1048,-1048}, +{ -969,-1258,-1608,-1608,-1608}, +{ -599, -888,-1238,-1238,-1238}}, +/* AU.GU..UG */ +{{ DEF, -339, -689, -689, -689}, +{ -859,-1148,-1498,-1498,-1498}, +{ -529, -818,-1168,-1168,-1168}, +{ -859,-1148,-1498,-1498,-1498}, +{ -409, -698,-1048,-1048,-1048}}}, +/* AU.U@..UG */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UA..UG */ +{{ DEF, -329, -329, -329, -329}, +{ -769,-1048,-1048,-1048,-1048}, +{ -529, -808, -808, -808, -808}, +{ -709, -988, -988, -988, -988}, +{ -599, -878, -878, -878, -878}}, +/* AU.UC..UG */ +{{ DEF, -329, -329, -329, -329}, +{ -839,-1118,-1118,-1118,-1118}, +{ -529, -808, -808, -808, -808}, +{ -859,-1138,-1138,-1138,-1138}, +{ -489, -768, -768, -768, -768}}, +/* AU.UG..UG */ +{{ DEF, -329, -329, -329, -329}, +{-1009,-1288,-1288,-1288,-1288}, +{ -409, -688, -688, -688, -688}, +{ -969,-1248,-1248,-1248,-1248}, +{ -599, -878, -878, -878, -878}}, +/* AU.UU..UG */ +{{ DEF, -329, -329, -329, -329}, +{ -859,-1138,-1138,-1138,-1138}, +{ -529, -808, -808, -808, -808}, +{ -859,-1138,-1138,-1138,-1138}, +{ -409, -688, -688, -688, -688}}}}, +/* AU.@@..AU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@A..AU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* AU.@C..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* AU.@G..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* AU.@U..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* AU.A@..AU */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AA..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -479, -858,-1028,-1028,-1028}, +{ -309, -688, -858, -858, -858}, +{ -389, -768, -938, -938, -938}, +{ -379, -758, -928, -928, -928}}, +/* AU.AC..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* AU.AG..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}, +/* AU.AU..AU */ +{{ DEF, -429, -599, -599, -599}, +{ -649,-1028,-1198,-1198,-1198}, +{ -289, -668, -838, -838, -838}, +{ -739,-1118,-1288,-1288,-1288}, +{ -379, -758, -928, -928, -928}}}, +/* AU.C@..AU */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CA..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -479, -688, -668, -668, -668}, +{ -309, -518, -498, -498, -498}, +{ -389, -598, -578, -578, -578}, +{ -379, -588, -568, -568, -568}}, +/* AU.CC..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* AU.CG..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}, +/* AU.CU..AU */ +{{ DEF, -259, -239, -239, -239}, +{ -649, -858, -838, -838, -838}, +{ -289, -498, -478, -478, -478}, +{ -739, -948, -928, -928, -928}, +{ -379, -588, -568, -568, -568}}}, +/* AU.G@..AU */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GA..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -479, -768,-1118,-1118,-1118}, +{ -309, -598, -948, -948, -948}, +{ -389, -678,-1028,-1028,-1028}, +{ -379, -668,-1018,-1018,-1018}}, +/* AU.GC..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* AU.GG..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}, +/* AU.GU..AU */ +{{ DEF, -339, -689, -689, -689}, +{ -649, -938,-1288,-1288,-1288}, +{ -289, -578, -928, -928, -928}, +{ -739,-1028,-1378,-1378,-1378}, +{ -379, -668,-1018,-1018,-1018}}}, +/* AU.U@..AU */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UA..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -479, -758, -758, -758, -758}, +{ -309, -588, -588, -588, -588}, +{ -389, -668, -668, -668, -668}, +{ -379, -658, -658, -658, -658}}, +/* AU.UC..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* AU.UG..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}, +/* AU.UU..AU */ +{{ DEF, -329, -329, -329, -329}, +{ -649, -928, -928, -928, -928}, +{ -289, -568, -568, -568, -568}, +{ -739,-1018,-1018,-1018,-1018}, +{ -379, -658, -658, -658, -658}}}}, +/* AU.@@..UA */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@A..UA */ +{{ 0, 0, 0, 0, 0}, +{ -399, -399, -399, -399, -399}, +{ -429, -429, -429, -429, -429}, +{ -379, -379, -379, -379, -379}, +{ -279, -279, -279, -279, -279}}, +/* AU.@C..UA */ +{{ 0, 0, 0, 0, 0}, +{ -629, -629, -629, -629, -629}, +{ -509, -509, -509, -509, -509}, +{ -679, -679, -679, -679, -679}, +{ -139, -139, -139, -139, -139}}, +/* AU.@G..UA */ +{{ 0, 0, 0, 0, 0}, +{ -889, -889, -889, -889, -889}, +{ -199, -199, -199, -199, -199}, +{ -889, -889, -889, -889, -889}, +{ -279, -279, -279, -279, -279}}, +/* AU.@U..UA */ +{{ 0, 0, 0, 0, 0}, +{ -589, -589, -589, -589, -589}, +{ -179, -179, -179, -179, -179}, +{ -679, -679, -679, -679, -679}, +{ -140, -140, -140, -140, -140}}}, +/* AU.A@..UA */ +{{{ DEF, -429, -599, -599, -599}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AA..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -449, -828, -998, -998, -998}, +{ -479, -858,-1028,-1028,-1028}, +{ -429, -808, -978, -978, -978}, +{ -329, -708, -878, -878, -878}}, +/* AU.AC..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -679,-1058,-1228,-1228,-1228}, +{ -559, -938,-1108,-1108,-1108}, +{ -729,-1108,-1278,-1278,-1278}, +{ -189, -568, -738, -738, -738}}, +/* AU.AG..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -939,-1318,-1488,-1488,-1488}, +{ -249, -628, -798, -798, -798}, +{ -939,-1318,-1488,-1488,-1488}, +{ -329, -708, -878, -878, -878}}, +/* AU.AU..UA */ +{{ DEF, -429, -599, -599, -599}, +{ -639,-1018,-1188,-1188,-1188}, +{ -229, -608, -778, -778, -778}, +{ -729,-1108,-1278,-1278,-1278}, +{ -190, -569, -739, -739, -739}}}, +/* AU.C@..UA */ +{{{ DEF, -259, -239, -239, -239}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CA..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -449, -658, -638, -638, -638}, +{ -479, -688, -668, -668, -668}, +{ -429, -638, -618, -618, -618}, +{ -329, -538, -518, -518, -518}}, +/* AU.CC..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -679, -888, -868, -868, -868}, +{ -559, -768, -748, -748, -748}, +{ -729, -938, -918, -918, -918}, +{ -189, -398, -378, -378, -378}}, +/* AU.CG..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -939,-1148,-1128,-1128,-1128}, +{ -249, -458, -438, -438, -438}, +{ -939,-1148,-1128,-1128,-1128}, +{ -329, -538, -518, -518, -518}}, +/* AU.CU..UA */ +{{ DEF, -259, -239, -239, -239}, +{ -639, -848, -828, -828, -828}, +{ -229, -438, -418, -418, -418}, +{ -729, -938, -918, -918, -918}, +{ -190, -399, -379, -379, -379}}}, +/* AU.G@..UA */ +{{{ DEF, -339, -689, -689, -689}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GA..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -449, -738,-1088,-1088,-1088}, +{ -479, -768,-1118,-1118,-1118}, +{ -429, -718,-1068,-1068,-1068}, +{ -329, -618, -968, -968, -968}}, +/* AU.GC..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -679, -968,-1318,-1318,-1318}, +{ -559, -848,-1198,-1198,-1198}, +{ -729,-1018,-1368,-1368,-1368}, +{ -189, -478, -828, -828, -828}}, +/* AU.GG..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -939,-1228,-1578,-1578,-1578}, +{ -249, -538, -888, -888, -888}, +{ -939,-1228,-1578,-1578,-1578}, +{ -329, -618, -968, -968, -968}}, +/* AU.GU..UA */ +{{ DEF, -339, -689, -689, -689}, +{ -639, -928,-1278,-1278,-1278}, +{ -229, -518, -868, -868, -868}, +{ -729,-1018,-1368,-1368,-1368}, +{ -190, -479, -829, -829, -829}}}, +/* AU.U@..UA */ +{{{ DEF, -329, -329, -329, -329}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UA..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -449, -728, -728, -728, -728}, +{ -479, -758, -758, -758, -758}, +{ -429, -708, -708, -708, -708}, +{ -329, -608, -608, -608, -608}}, +/* AU.UC..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -679, -958, -958, -958, -958}, +{ -559, -838, -838, -838, -838}, +{ -729,-1008,-1008,-1008,-1008}, +{ -189, -468, -468, -468, -468}}, +/* AU.UG..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -939,-1218,-1218,-1218,-1218}, +{ -249, -528, -528, -528, -528}, +{ -939,-1218,-1218,-1218,-1218}, +{ -329, -608, -608, -608, -608}}, +/* AU.UU..UA */ +{{ DEF, -329, -329, -329, -329}, +{ -639, -918, -918, -918, -918}, +{ -229, -508, -508, -508, -508}, +{ -729,-1008,-1008,-1008,-1008}, +{ -190, -469, -469, -469, -469}}}}, +/* AU.@@.. @ */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@A.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@C.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@G.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* AU.@U.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}}, +/* AU.A@.. @ */ +{{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AA.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AC.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AG.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}, +/* AU.AU.. @ */ +{{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}, +{ -100, -479, -649, -649, -649}}}, +/* AU.C@.. @ */ +{{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CA.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CC.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CG.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}, +/* AU.CU.. @ */ +{{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}, +{ -100, -309, -289, -289, -289}}}, +/* AU.G@.. @ */ +{{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GA.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GC.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GG.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}, +/* AU.GU.. @ */ +{{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}, +{ -100, -389, -739, -739, -739}}}, +/* AU.U@.. @ */ +{{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UA.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UC.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UG.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}, +/* AU.UU.. @ */ +{{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}, +{ -100, -379, -379, -379, -379}}}}}, +{ /* noPair */ {{{{0}}}}, +/* UA.@@..CG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@A..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* UA.@C..CG */ +{{ 0, 0, 0, 0, 0}, +{ -949, -949, -949, -949, -949}, +{ -449, -449, -449, -449, -449}, +{ -939, -939, -939, -939, -939}, +{ -739, -739, -739, -739, -739}}, +/* UA.@G..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -519, -519, -519, -519, -519}, +{ -939, -939, -939, -939, -939}, +{ -809, -809, -809, -809, -809}}, +/* UA.@U..CG */ +{{ 0, 0, 0, 0, 0}, +{-1029,-1029,-1029,-1029,-1029}, +{ -669, -669, -669, -669, -669}, +{ -939, -939, -939, -939, -939}, +{ -859, -859, -859, -859, -859}}}, +/* UA.A@..CG */ +{{{ DEF, -399, -629, -889, -589}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AA..CG */ +{{ DEF, -399, -629, -889, -589}, +{-1079,-1428,-1658,-1918,-1618}, +{ -569, -918,-1148,-1408,-1108}, +{ -989,-1338,-1568,-1828,-1528}, +{ -859,-1208,-1438,-1698,-1398}}, +/* UA.AC..CG */ +{{ DEF, -399, -629, -889, -589}, +{ -999,-1348,-1578,-1838,-1538}, +{ -499, -848,-1078,-1338,-1038}, +{ -989,-1338,-1568,-1828,-1528}, +{ -789,-1138,-1368,-1628,-1328}}, +/* UA.AG..CG */ +{{ DEF, -399, -629, -889, -589}, +{-1079,-1428,-1658,-1918,-1618}, +{ -569, -918,-1148,-1408,-1108}, +{ -989,-1338,-1568,-1828,-1528}, +{ -859,-1208,-1438,-1698,-1398}}, +/* UA.AU..CG */ +{{ DEF, -399, -629, -889, -589}, +{-1079,-1428,-1658,-1918,-1618}, +{ -719,-1068,-1298,-1558,-1258}, +{ -989,-1338,-1568,-1828,-1528}, +{ -909,-1258,-1488,-1748,-1448}}}, +/* UA.C@..CG */ +{{{ DEF, -429, -509, -199, -179}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CA..CG */ +{{ DEF, -429, -509, -199, -179}, +{-1079,-1458,-1538,-1228,-1208}, +{ -569, -948,-1028, -718, -698}, +{ -989,-1368,-1448,-1138,-1118}, +{ -859,-1238,-1318,-1008, -988}}, +/* UA.CC..CG */ +{{ DEF, -429, -509, -199, -179}, +{ -999,-1378,-1458,-1148,-1128}, +{ -499, -878, -958, -648, -628}, +{ -989,-1368,-1448,-1138,-1118}, +{ -789,-1168,-1248, -938, -918}}, +/* UA.CG..CG */ +{{ DEF, -429, -509, -199, -179}, +{-1079,-1458,-1538,-1228,-1208}, +{ -569, -948,-1028, -718, -698}, +{ -989,-1368,-1448,-1138,-1118}, +{ -859,-1238,-1318,-1008, -988}}, +/* UA.CU..CG */ +{{ DEF, -429, -509, -199, -179}, +{-1079,-1458,-1538,-1228,-1208}, +{ -719,-1098,-1178, -868, -848}, +{ -989,-1368,-1448,-1138,-1118}, +{ -909,-1288,-1368,-1058,-1038}}}, +/* UA.G@..CG */ +{{{ DEF, -379, -679, -889, -679}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GA..CG */ +{{ DEF, -379, -679, -889, -679}, +{-1079,-1408,-1708,-1918,-1708}, +{ -569, -898,-1198,-1408,-1198}, +{ -989,-1318,-1618,-1828,-1618}, +{ -859,-1188,-1488,-1698,-1488}}, +/* UA.GC..CG */ +{{ DEF, -379, -679, -889, -679}, +{ -999,-1328,-1628,-1838,-1628}, +{ -499, -828,-1128,-1338,-1128}, +{ -989,-1318,-1618,-1828,-1618}, +{ -789,-1118,-1418,-1628,-1418}}, +/* UA.GG..CG */ +{{ DEF, -379, -679, -889, -679}, +{-1079,-1408,-1708,-1918,-1708}, +{ -569, -898,-1198,-1408,-1198}, +{ -989,-1318,-1618,-1828,-1618}, +{ -859,-1188,-1488,-1698,-1488}}, +/* UA.GU..CG */ +{{ DEF, -379, -679, -889, -679}, +{-1079,-1408,-1708,-1918,-1708}, +{ -719,-1048,-1348,-1558,-1348}, +{ -989,-1318,-1618,-1828,-1618}, +{ -909,-1238,-1538,-1748,-1538}}}, +/* UA.U@..CG */ +{{{ DEF, -279, -139, -279, -140}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UA..CG */ +{{ DEF, -279, -139, -279, -140}, +{-1079,-1308,-1168,-1308,-1169}, +{ -569, -798, -658, -798, -659}, +{ -989,-1218,-1078,-1218,-1079}, +{ -859,-1088, -948,-1088, -949}}, +/* UA.UC..CG */ +{{ DEF, -279, -139, -279, -140}, +{ -999,-1228,-1088,-1228,-1089}, +{ -499, -728, -588, -728, -589}, +{ -989,-1218,-1078,-1218,-1079}, +{ -789,-1018, -878,-1018, -879}}, +/* UA.UG..CG */ +{{ DEF, -279, -139, -279, -140}, +{-1079,-1308,-1168,-1308,-1169}, +{ -569, -798, -658, -798, -659}, +{ -989,-1218,-1078,-1218,-1079}, +{ -859,-1088, -948,-1088, -949}}, +/* UA.UU..CG */ +{{ DEF, -279, -139, -279, -140}, +{-1079,-1308,-1168,-1308,-1169}, +{ -719, -948, -808, -948, -809}, +{ -989,-1218,-1078,-1218,-1079}, +{ -909,-1138, -998,-1138, -999}}}}, +/* UA.@@..GC */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@A..GC */ +{{ 0, 0, 0, 0, 0}, +{ -519, -519, -519, -519, -519}, +{ -719, -719, -719, -719, -719}, +{ -709, -709, -709, -709, -709}, +{ -499, -499, -499, -499, -499}}, +/* UA.@C..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -309, -309, -309, -309, -309}, +{ -739, -739, -739, -739, -739}, +{ -499, -499, -499, -499, -499}}, +/* UA.@G..GC */ +{{ 0, 0, 0, 0, 0}, +{ -559, -559, -559, -559, -559}, +{ -309, -309, -309, -309, -309}, +{ -619, -619, -619, -619, -619}, +{ -499, -499, -499, -499, -499}}, +/* UA.@U..GC */ +{{ 0, 0, 0, 0, 0}, +{ -879, -879, -879, -879, -879}, +{ -389, -389, -389, -389, -389}, +{ -739, -739, -739, -739, -739}, +{ -569, -569, -569, -569, -569}}}, +/* UA.A@..GC */ +{{{ DEF, -399, -629, -889, -589}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AA..GC */ +{{ DEF, -399, -629, -889, -589}, +{ -569, -918,-1148,-1408,-1108}, +{ -769,-1118,-1348,-1608,-1308}, +{ -759,-1108,-1338,-1598,-1298}, +{ -549, -898,-1128,-1388,-1088}}, +/* UA.AC..GC */ +{{ DEF, -399, -629, -889, -589}, +{ -929,-1278,-1508,-1768,-1468}, +{ -359, -708, -938,-1198, -898}, +{ -789,-1138,-1368,-1628,-1328}, +{ -549, -898,-1128,-1388,-1088}}, +/* UA.AG..GC */ +{{ DEF, -399, -629, -889, -589}, +{ -609, -958,-1188,-1448,-1148}, +{ -359, -708, -938,-1198, -898}, +{ -669,-1018,-1248,-1508,-1208}, +{ -549, -898,-1128,-1388,-1088}}, +/* UA.AU..GC */ +{{ DEF, -399, -629, -889, -589}, +{ -929,-1278,-1508,-1768,-1468}, +{ -439, -788,-1018,-1278, -978}, +{ -789,-1138,-1368,-1628,-1328}, +{ -619, -968,-1198,-1458,-1158}}}, +/* UA.C@..GC */ +{{{ DEF, -429, -509, -199, -179}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CA..GC */ +{{ DEF, -429, -509, -199, -179}, +{ -569, -948,-1028, -718, -698}, +{ -769,-1148,-1228, -918, -898}, +{ -759,-1138,-1218, -908, -888}, +{ -549, -928,-1008, -698, -678}}, +/* UA.CC..GC */ +{{ DEF, -429, -509, -199, -179}, +{ -929,-1308,-1388,-1078,-1058}, +{ -359, -738, -818, -508, -488}, +{ -789,-1168,-1248, -938, -918}, +{ -549, -928,-1008, -698, -678}}, +/* UA.CG..GC */ +{{ DEF, -429, -509, -199, -179}, +{ -609, -988,-1068, -758, -738}, +{ -359, -738, -818, -508, -488}, +{ -669,-1048,-1128, -818, -798}, +{ -549, -928,-1008, -698, -678}}, +/* UA.CU..GC */ +{{ DEF, -429, -509, -199, -179}, +{ -929,-1308,-1388,-1078,-1058}, +{ -439, -818, -898, -588, -568}, +{ -789,-1168,-1248, -938, -918}, +{ -619, -998,-1078, -768, -748}}}, +/* UA.G@..GC */ +{{{ DEF, -379, -679, -889, -679}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GA..GC */ +{{ DEF, -379, -679, -889, -679}, +{ -569, -898,-1198,-1408,-1198}, +{ -769,-1098,-1398,-1608,-1398}, +{ -759,-1088,-1388,-1598,-1388}, +{ -549, -878,-1178,-1388,-1178}}, +/* UA.GC..GC */ +{{ DEF, -379, -679, -889, -679}, +{ -929,-1258,-1558,-1768,-1558}, +{ -359, -688, -988,-1198, -988}, +{ -789,-1118,-1418,-1628,-1418}, +{ -549, -878,-1178,-1388,-1178}}, +/* UA.GG..GC */ +{{ DEF, -379, -679, -889, -679}, +{ -609, -938,-1238,-1448,-1238}, +{ -359, -688, -988,-1198, -988}, +{ -669, -998,-1298,-1508,-1298}, +{ -549, -878,-1178,-1388,-1178}}, +/* UA.GU..GC */ +{{ DEF, -379, -679, -889, -679}, +{ -929,-1258,-1558,-1768,-1558}, +{ -439, -768,-1068,-1278,-1068}, +{ -789,-1118,-1418,-1628,-1418}, +{ -619, -948,-1248,-1458,-1248}}}, +/* UA.U@..GC */ +{{{ DEF, -279, -139, -279, -140}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UA..GC */ +{{ DEF, -279, -139, -279, -140}, +{ -569, -798, -658, -798, -659}, +{ -769, -998, -858, -998, -859}, +{ -759, -988, -848, -988, -849}, +{ -549, -778, -638, -778, -639}}, +/* UA.UC..GC */ +{{ DEF, -279, -139, -279, -140}, +{ -929,-1158,-1018,-1158,-1019}, +{ -359, -588, -448, -588, -449}, +{ -789,-1018, -878,-1018, -879}, +{ -549, -778, -638, -778, -639}}, +/* UA.UG..GC */ +{{ DEF, -279, -139, -279, -140}, +{ -609, -838, -698, -838, -699}, +{ -359, -588, -448, -588, -449}, +{ -669, -898, -758, -898, -759}, +{ -549, -778, -638, -778, -639}}, +/* UA.UU..GC */ +{{ DEF, -279, -139, -279, -140}, +{ -929,-1158,-1018,-1158,-1019}, +{ -439, -668, -528, -668, -529}, +{ -789,-1018, -878,-1018, -879}, +{ -619, -848, -708, -848, -709}}}}, +/* UA.@@..GU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@A..GU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* UA.@C..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UA.@G..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UA.@U..GU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* UA.A@..GU */ +{{{ DEF, -399, -629, -889, -589}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AA..GU */ +{{ DEF, -399, -629, -889, -589}, +{ -479, -828,-1058,-1318,-1018}, +{ -309, -658, -888,-1148, -848}, +{ -389, -738, -968,-1228, -928}, +{ -379, -728, -958,-1218, -918}}, +/* UA.AC..GU */ +{{ DEF, -399, -629, -889, -589}, +{ -649, -998,-1228,-1488,-1188}, +{ -289, -638, -868,-1128, -828}, +{ -739,-1088,-1318,-1578,-1278}, +{ -379, -728, -958,-1218, -918}}, +/* UA.AG..GU */ +{{ DEF, -399, -629, -889, -589}, +{ -649, -998,-1228,-1488,-1188}, +{ -289, -638, -868,-1128, -828}, +{ -739,-1088,-1318,-1578,-1278}, +{ -379, -728, -958,-1218, -918}}, +/* UA.AU..GU */ +{{ DEF, -399, -629, -889, -589}, +{ -649, -998,-1228,-1488,-1188}, +{ -289, -638, -868,-1128, -828}, +{ -739,-1088,-1318,-1578,-1278}, +{ -379, -728, -958,-1218, -918}}}, +/* UA.C@..GU */ +{{{ DEF, -429, -509, -199, -179}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CA..GU */ +{{ DEF, -429, -509, -199, -179}, +{ -479, -858, -938, -628, -608}, +{ -309, -688, -768, -458, -438}, +{ -389, -768, -848, -538, -518}, +{ -379, -758, -838, -528, -508}}, +/* UA.CC..GU */ +{{ DEF, -429, -509, -199, -179}, +{ -649,-1028,-1108, -798, -778}, +{ -289, -668, -748, -438, -418}, +{ -739,-1118,-1198, -888, -868}, +{ -379, -758, -838, -528, -508}}, +/* UA.CG..GU */ +{{ DEF, -429, -509, -199, -179}, +{ -649,-1028,-1108, -798, -778}, +{ -289, -668, -748, -438, -418}, +{ -739,-1118,-1198, -888, -868}, +{ -379, -758, -838, -528, -508}}, +/* UA.CU..GU */ +{{ DEF, -429, -509, -199, -179}, +{ -649,-1028,-1108, -798, -778}, +{ -289, -668, -748, -438, -418}, +{ -739,-1118,-1198, -888, -868}, +{ -379, -758, -838, -528, -508}}}, +/* UA.G@..GU */ +{{{ DEF, -379, -679, -889, -679}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GA..GU */ +{{ DEF, -379, -679, -889, -679}, +{ -479, -808,-1108,-1318,-1108}, +{ -309, -638, -938,-1148, -938}, +{ -389, -718,-1018,-1228,-1018}, +{ -379, -708,-1008,-1218,-1008}}, +/* UA.GC..GU */ +{{ DEF, -379, -679, -889, -679}, +{ -649, -978,-1278,-1488,-1278}, +{ -289, -618, -918,-1128, -918}, +{ -739,-1068,-1368,-1578,-1368}, +{ -379, -708,-1008,-1218,-1008}}, +/* UA.GG..GU */ +{{ DEF, -379, -679, -889, -679}, +{ -649, -978,-1278,-1488,-1278}, +{ -289, -618, -918,-1128, -918}, +{ -739,-1068,-1368,-1578,-1368}, +{ -379, -708,-1008,-1218,-1008}}, +/* UA.GU..GU */ +{{ DEF, -379, -679, -889, -679}, +{ -649, -978,-1278,-1488,-1278}, +{ -289, -618, -918,-1128, -918}, +{ -739,-1068,-1368,-1578,-1368}, +{ -379, -708,-1008,-1218,-1008}}}, +/* UA.U@..GU */ +{{{ DEF, -279, -139, -279, -140}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UA..GU */ +{{ DEF, -279, -139, -279, -140}, +{ -479, -708, -568, -708, -569}, +{ -309, -538, -398, -538, -399}, +{ -389, -618, -478, -618, -479}, +{ -379, -608, -468, -608, -469}}, +/* UA.UC..GU */ +{{ DEF, -279, -139, -279, -140}, +{ -649, -878, -738, -878, -739}, +{ -289, -518, -378, -518, -379}, +{ -739, -968, -828, -968, -829}, +{ -379, -608, -468, -608, -469}}, +/* UA.UG..GU */ +{{ DEF, -279, -139, -279, -140}, +{ -649, -878, -738, -878, -739}, +{ -289, -518, -378, -518, -379}, +{ -739, -968, -828, -968, -829}, +{ -379, -608, -468, -608, -469}}, +/* UA.UU..GU */ +{{ DEF, -279, -139, -279, -140}, +{ -649, -878, -738, -878, -739}, +{ -289, -518, -378, -518, -379}, +{ -739, -968, -828, -968, -829}, +{ -379, -608, -468, -608, -469}}}}, +/* UA.@@..UG */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@A..UG */ +{{ 0, 0, 0, 0, 0}, +{ -719, -719, -719, -719, -719}, +{ -479, -479, -479, -479, -479}, +{ -659, -659, -659, -659, -659}, +{ -549, -549, -549, -549, -549}}, +/* UA.@C..UG */ +{{ 0, 0, 0, 0, 0}, +{ -789, -789, -789, -789, -789}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -439, -439, -439, -439, -439}}, +/* UA.@G..UG */ +{{ 0, 0, 0, 0, 0}, +{ -959, -959, -959, -959, -959}, +{ -359, -359, -359, -359, -359}, +{ -919, -919, -919, -919, -919}, +{ -549, -549, -549, -549, -549}}, +/* UA.@U..UG */ +{{ 0, 0, 0, 0, 0}, +{ -809, -809, -809, -809, -809}, +{ -479, -479, -479, -479, -479}, +{ -809, -809, -809, -809, -809}, +{ -359, -359, -359, -359, -359}}}, +/* UA.A@..UG */ +{{{ DEF, -399, -629, -889, -589}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AA..UG */ +{{ DEF, -399, -629, -889, -589}, +{ -769,-1118,-1348,-1608,-1308}, +{ -529, -878,-1108,-1368,-1068}, +{ -709,-1058,-1288,-1548,-1248}, +{ -599, -948,-1178,-1438,-1138}}, +/* UA.AC..UG */ +{{ DEF, -399, -629, -889, -589}, +{ -839,-1188,-1418,-1678,-1378}, +{ -529, -878,-1108,-1368,-1068}, +{ -859,-1208,-1438,-1698,-1398}, +{ -489, -838,-1068,-1328,-1028}}, +/* UA.AG..UG */ +{{ DEF, -399, -629, -889, -589}, +{-1009,-1358,-1588,-1848,-1548}, +{ -409, -758, -988,-1248, -948}, +{ -969,-1318,-1548,-1808,-1508}, +{ -599, -948,-1178,-1438,-1138}}, +/* UA.AU..UG */ +{{ DEF, -399, -629, -889, -589}, +{ -859,-1208,-1438,-1698,-1398}, +{ -529, -878,-1108,-1368,-1068}, +{ -859,-1208,-1438,-1698,-1398}, +{ -409, -758, -988,-1248, -948}}}, +/* UA.C@..UG */ +{{{ DEF, -429, -509, -199, -179}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CA..UG */ +{{ DEF, -429, -509, -199, -179}, +{ -769,-1148,-1228, -918, -898}, +{ -529, -908, -988, -678, -658}, +{ -709,-1088,-1168, -858, -838}, +{ -599, -978,-1058, -748, -728}}, +/* UA.CC..UG */ +{{ DEF, -429, -509, -199, -179}, +{ -839,-1218,-1298, -988, -968}, +{ -529, -908, -988, -678, -658}, +{ -859,-1238,-1318,-1008, -988}, +{ -489, -868, -948, -638, -618}}, +/* UA.CG..UG */ +{{ DEF, -429, -509, -199, -179}, +{-1009,-1388,-1468,-1158,-1138}, +{ -409, -788, -868, -558, -538}, +{ -969,-1348,-1428,-1118,-1098}, +{ -599, -978,-1058, -748, -728}}, +/* UA.CU..UG */ +{{ DEF, -429, -509, -199, -179}, +{ -859,-1238,-1318,-1008, -988}, +{ -529, -908, -988, -678, -658}, +{ -859,-1238,-1318,-1008, -988}, +{ -409, -788, -868, -558, -538}}}, +/* UA.G@..UG */ +{{{ DEF, -379, -679, -889, -679}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GA..UG */ +{{ DEF, -379, -679, -889, -679}, +{ -769,-1098,-1398,-1608,-1398}, +{ -529, -858,-1158,-1368,-1158}, +{ -709,-1038,-1338,-1548,-1338}, +{ -599, -928,-1228,-1438,-1228}}, +/* UA.GC..UG */ +{{ DEF, -379, -679, -889, -679}, +{ -839,-1168,-1468,-1678,-1468}, +{ -529, -858,-1158,-1368,-1158}, +{ -859,-1188,-1488,-1698,-1488}, +{ -489, -818,-1118,-1328,-1118}}, +/* UA.GG..UG */ +{{ DEF, -379, -679, -889, -679}, +{-1009,-1338,-1638,-1848,-1638}, +{ -409, -738,-1038,-1248,-1038}, +{ -969,-1298,-1598,-1808,-1598}, +{ -599, -928,-1228,-1438,-1228}}, +/* UA.GU..UG */ +{{ DEF, -379, -679, -889, -679}, +{ -859,-1188,-1488,-1698,-1488}, +{ -529, -858,-1158,-1368,-1158}, +{ -859,-1188,-1488,-1698,-1488}, +{ -409, -738,-1038,-1248,-1038}}}, +/* UA.U@..UG */ +{{{ DEF, -279, -139, -279, -140}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UA..UG */ +{{ DEF, -279, -139, -279, -140}, +{ -769, -998, -858, -998, -859}, +{ -529, -758, -618, -758, -619}, +{ -709, -938, -798, -938, -799}, +{ -599, -828, -688, -828, -689}}, +/* UA.UC..UG */ +{{ DEF, -279, -139, -279, -140}, +{ -839,-1068, -928,-1068, -929}, +{ -529, -758, -618, -758, -619}, +{ -859,-1088, -948,-1088, -949}, +{ -489, -718, -578, -718, -579}}, +/* UA.UG..UG */ +{{ DEF, -279, -139, -279, -140}, +{-1009,-1238,-1098,-1238,-1099}, +{ -409, -638, -498, -638, -499}, +{ -969,-1198,-1058,-1198,-1059}, +{ -599, -828, -688, -828, -689}}, +/* UA.UU..UG */ +{{ DEF, -279, -139, -279, -140}, +{ -859,-1088, -948,-1088, -949}, +{ -529, -758, -618, -758, -619}, +{ -859,-1088, -948,-1088, -949}, +{ -409, -638, -498, -638, -499}}}}, +/* UA.@@..AU */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@A..AU */ +{{ 0, 0, 0, 0, 0}, +{ -429, -429, -429, -429, -429}, +{ -259, -259, -259, -259, -259}, +{ -339, -339, -339, -339, -339}, +{ -329, -329, -329, -329, -329}}, +/* UA.@C..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UA.@G..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}, +/* UA.@U..AU */ +{{ 0, 0, 0, 0, 0}, +{ -599, -599, -599, -599, -599}, +{ -239, -239, -239, -239, -239}, +{ -689, -689, -689, -689, -689}, +{ -329, -329, -329, -329, -329}}}, +/* UA.A@..AU */ +{{{ DEF, -399, -629, -889, -589}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AA..AU */ +{{ DEF, -399, -629, -889, -589}, +{ -479, -828,-1058,-1318,-1018}, +{ -309, -658, -888,-1148, -848}, +{ -389, -738, -968,-1228, -928}, +{ -379, -728, -958,-1218, -918}}, +/* UA.AC..AU */ +{{ DEF, -399, -629, -889, -589}, +{ -649, -998,-1228,-1488,-1188}, +{ -289, -638, -868,-1128, -828}, +{ -739,-1088,-1318,-1578,-1278}, +{ -379, -728, -958,-1218, -918}}, +/* UA.AG..AU */ +{{ DEF, -399, -629, -889, -589}, +{ -649, -998,-1228,-1488,-1188}, +{ -289, -638, -868,-1128, -828}, +{ -739,-1088,-1318,-1578,-1278}, +{ -379, -728, -958,-1218, -918}}, +/* UA.AU..AU */ +{{ DEF, -399, -629, -889, -589}, +{ -649, -998,-1228,-1488,-1188}, +{ -289, -638, -868,-1128, -828}, +{ -739,-1088,-1318,-1578,-1278}, +{ -379, -728, -958,-1218, -918}}}, +/* UA.C@..AU */ +{{{ DEF, -429, -509, -199, -179}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CA..AU */ +{{ DEF, -429, -509, -199, -179}, +{ -479, -858, -938, -628, -608}, +{ -309, -688, -768, -458, -438}, +{ -389, -768, -848, -538, -518}, +{ -379, -758, -838, -528, -508}}, +/* UA.CC..AU */ +{{ DEF, -429, -509, -199, -179}, +{ -649,-1028,-1108, -798, -778}, +{ -289, -668, -748, -438, -418}, +{ -739,-1118,-1198, -888, -868}, +{ -379, -758, -838, -528, -508}}, +/* UA.CG..AU */ +{{ DEF, -429, -509, -199, -179}, +{ -649,-1028,-1108, -798, -778}, +{ -289, -668, -748, -438, -418}, +{ -739,-1118,-1198, -888, -868}, +{ -379, -758, -838, -528, -508}}, +/* UA.CU..AU */ +{{ DEF, -429, -509, -199, -179}, +{ -649,-1028,-1108, -798, -778}, +{ -289, -668, -748, -438, -418}, +{ -739,-1118,-1198, -888, -868}, +{ -379, -758, -838, -528, -508}}}, +/* UA.G@..AU */ +{{{ DEF, -379, -679, -889, -679}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GA..AU */ +{{ DEF, -379, -679, -889, -679}, +{ -479, -808,-1108,-1318,-1108}, +{ -309, -638, -938,-1148, -938}, +{ -389, -718,-1018,-1228,-1018}, +{ -379, -708,-1008,-1218,-1008}}, +/* UA.GC..AU */ +{{ DEF, -379, -679, -889, -679}, +{ -649, -978,-1278,-1488,-1278}, +{ -289, -618, -918,-1128, -918}, +{ -739,-1068,-1368,-1578,-1368}, +{ -379, -708,-1008,-1218,-1008}}, +/* UA.GG..AU */ +{{ DEF, -379, -679, -889, -679}, +{ -649, -978,-1278,-1488,-1278}, +{ -289, -618, -918,-1128, -918}, +{ -739,-1068,-1368,-1578,-1368}, +{ -379, -708,-1008,-1218,-1008}}, +/* UA.GU..AU */ +{{ DEF, -379, -679, -889, -679}, +{ -649, -978,-1278,-1488,-1278}, +{ -289, -618, -918,-1128, -918}, +{ -739,-1068,-1368,-1578,-1368}, +{ -379, -708,-1008,-1218,-1008}}}, +/* UA.U@..AU */ +{{{ DEF, -279, -139, -279, -140}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UA..AU */ +{{ DEF, -279, -139, -279, -140}, +{ -479, -708, -568, -708, -569}, +{ -309, -538, -398, -538, -399}, +{ -389, -618, -478, -618, -479}, +{ -379, -608, -468, -608, -469}}, +/* UA.UC..AU */ +{{ DEF, -279, -139, -279, -140}, +{ -649, -878, -738, -878, -739}, +{ -289, -518, -378, -518, -379}, +{ -739, -968, -828, -968, -829}, +{ -379, -608, -468, -608, -469}}, +/* UA.UG..AU */ +{{ DEF, -279, -139, -279, -140}, +{ -649, -878, -738, -878, -739}, +{ -289, -518, -378, -518, -379}, +{ -739, -968, -828, -968, -829}, +{ -379, -608, -468, -608, -469}}, +/* UA.UU..AU */ +{{ DEF, -279, -139, -279, -140}, +{ -649, -878, -738, -878, -739}, +{ -289, -518, -378, -518, -379}, +{ -739, -968, -828, -968, -829}, +{ -379, -608, -468, -608, -469}}}}, +/* UA.@@..UA */ +{{{{ 0, 0, 0, 0, 0}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@A..UA */ +{{ 0, 0, 0, 0, 0}, +{ -399, -399, -399, -399, -399}, +{ -429, -429, -429, -429, -429}, +{ -379, -379, -379, -379, -379}, +{ -279, -279, -279, -279, -279}}, +/* UA.@C..UA */ +{{ 0, 0, 0, 0, 0}, +{ -629, -629, -629, -629, -629}, +{ -509, -509, -509, -509, -509}, +{ -679, -679, -679, -679, -679}, +{ -139, -139, -139, -139, -139}}, +/* UA.@G..UA */ +{{ 0, 0, 0, 0, 0}, +{ -889, -889, -889, -889, -889}, +{ -199, -199, -199, -199, -199}, +{ -889, -889, -889, -889, -889}, +{ -279, -279, -279, -279, -279}}, +/* UA.@U..UA */ +{{ 0, 0, 0, 0, 0}, +{ -589, -589, -589, -589, -589}, +{ -179, -179, -179, -179, -179}, +{ -679, -679, -679, -679, -679}, +{ -140, -140, -140, -140, -140}}}, +/* UA.A@..UA */ +{{{ DEF, -399, -629, -889, -589}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AA..UA */ +{{ DEF, -399, -629, -889, -589}, +{ -449, -798,-1028,-1288, -988}, +{ -479, -828,-1058,-1318,-1018}, +{ -429, -778,-1008,-1268, -968}, +{ -329, -678, -908,-1168, -868}}, +/* UA.AC..UA */ +{{ DEF, -399, -629, -889, -589}, +{ -679,-1028,-1258,-1518,-1218}, +{ -559, -908,-1138,-1398,-1098}, +{ -729,-1078,-1308,-1568,-1268}, +{ -189, -538, -768,-1028, -728}}, +/* UA.AG..UA */ +{{ DEF, -399, -629, -889, -589}, +{ -939,-1288,-1518,-1778,-1478}, +{ -249, -598, -828,-1088, -788}, +{ -939,-1288,-1518,-1778,-1478}, +{ -329, -678, -908,-1168, -868}}, +/* UA.AU..UA */ +{{ DEF, -399, -629, -889, -589}, +{ -639, -988,-1218,-1478,-1178}, +{ -229, -578, -808,-1068, -768}, +{ -729,-1078,-1308,-1568,-1268}, +{ -190, -539, -769,-1029, -729}}}, +/* UA.C@..UA */ +{{{ DEF, -429, -509, -199, -179}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CA..UA */ +{{ DEF, -429, -509, -199, -179}, +{ -449, -828, -908, -598, -578}, +{ -479, -858, -938, -628, -608}, +{ -429, -808, -888, -578, -558}, +{ -329, -708, -788, -478, -458}}, +/* UA.CC..UA */ +{{ DEF, -429, -509, -199, -179}, +{ -679,-1058,-1138, -828, -808}, +{ -559, -938,-1018, -708, -688}, +{ -729,-1108,-1188, -878, -858}, +{ -189, -568, -648, -338, -318}}, +/* UA.CG..UA */ +{{ DEF, -429, -509, -199, -179}, +{ -939,-1318,-1398,-1088,-1068}, +{ -249, -628, -708, -398, -378}, +{ -939,-1318,-1398,-1088,-1068}, +{ -329, -708, -788, -478, -458}}, +/* UA.CU..UA */ +{{ DEF, -429, -509, -199, -179}, +{ -639,-1018,-1098, -788, -768}, +{ -229, -608, -688, -378, -358}, +{ -729,-1108,-1188, -878, -858}, +{ -190, -569, -649, -339, -319}}}, +/* UA.G@..UA */ +{{{ DEF, -379, -679, -889, -679}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GA..UA */ +{{ DEF, -379, -679, -889, -679}, +{ -449, -778,-1078,-1288,-1078}, +{ -479, -808,-1108,-1318,-1108}, +{ -429, -758,-1058,-1268,-1058}, +{ -329, -658, -958,-1168, -958}}, +/* UA.GC..UA */ +{{ DEF, -379, -679, -889, -679}, +{ -679,-1008,-1308,-1518,-1308}, +{ -559, -888,-1188,-1398,-1188}, +{ -729,-1058,-1358,-1568,-1358}, +{ -189, -518, -818,-1028, -818}}, +/* UA.GG..UA */ +{{ DEF, -379, -679, -889, -679}, +{ -939,-1268,-1568,-1778,-1568}, +{ -249, -578, -878,-1088, -878}, +{ -939,-1268,-1568,-1778,-1568}, +{ -329, -658, -958,-1168, -958}}, +/* UA.GU..UA */ +{{ DEF, -379, -679, -889, -679}, +{ -639, -968,-1268,-1478,-1268}, +{ -229, -558, -858,-1068, -858}, +{ -729,-1058,-1358,-1568,-1358}, +{ -190, -519, -819,-1029, -819}}}, +/* UA.U@..UA */ +{{{ DEF, -279, -139, -279, -140}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UA..UA */ +{{ DEF, -279, -139, -279, -140}, +{ -449, -678, -538, -678, -539}, +{ -479, -708, -568, -708, -569}, +{ -429, -658, -518, -658, -519}, +{ -329, -558, -418, -558, -419}}, +/* UA.UC..UA */ +{{ DEF, -279, -139, -279, -140}, +{ -679, -908, -768, -908, -769}, +{ -559, -788, -648, -788, -649}, +{ -729, -958, -818, -958, -819}, +{ -189, -418, -278, -418, -279}}, +/* UA.UG..UA */ +{{ DEF, -279, -139, -279, -140}, +{ -939,-1168,-1028,-1168,-1029}, +{ -249, -478, -338, -478, -339}, +{ -939,-1168,-1028,-1168,-1029}, +{ -329, -558, -418, -558, -419}}, +/* UA.UU..UA */ +{{ DEF, -279, -139, -279, -140}, +{ -639, -868, -728, -868, -729}, +{ -229, -458, -318, -458, -319}, +{ -729, -958, -818, -958, -819}, +{ -190, -419, -279, -419, -280}}}}, +/* UA.@@.. @ */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@A.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@C.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@G.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}, +/* UA.@U.. @ */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}, +{ DEF, DEF, DEF, DEF, DEF}}}, +/* UA.A@.. @ */ +{{{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AA.. @ */ +{{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AC.. @ */ +{{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AG.. @ */ +{{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}, +/* UA.AU.. @ */ +{{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}, +{ -100, -449, -679, -939, -639}}}, +/* UA.C@.. @ */ +{{{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CA.. @ */ +{{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CC.. @ */ +{{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CG.. @ */ +{{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}, +/* UA.CU.. @ */ +{{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}, +{ -100, -479, -559, -249, -229}}}, +/* UA.G@.. @ */ +{{{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GA.. @ */ +{{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GC.. @ */ +{{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GG.. @ */ +{{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}, +/* UA.GU.. @ */ +{{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}, +{ -100, -429, -729, -939, -729}}}, +/* UA.U@.. @ */ +{{{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UA.. @ */ +{{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UC.. @ */ +{{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UG.. @ */ +{{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}, +/* UA.UU.. @ */ +{{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}, +{ -100, -329, -189, -329, -190}}}}}, +{ /* noPair */ {{{{0}}}}, +/* @.@@..CG */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@A..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.@C..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -999, -999, -999, -999, -999}, +{ -499, -499, -499, -499, -499}, +{ -989, -989, -989, -989, -989}, +{ -789, -789, -789, -789, -789}}, +/* @.@G..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.@U..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -719, -719, -719, -719, -719}, +{ -989, -989, -989, -989, -989}, +{ -909, -909, -909, -909, -909}}}, +/* @.A@..CG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AA..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.AC..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -999, -999, -999, -999, -999}, +{ -499, -499, -499, -499, -499}, +{ -989, -989, -989, -989, -989}, +{ -789, -789, -789, -789, -789}}, +/* @.AG..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.AU..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -719, -719, -719, -719, -719}, +{ -989, -989, -989, -989, -989}, +{ -909, -909, -909, -909, -909}}}, +/* @.C@..CG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CA..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.CC..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -999, -999, -999, -999, -999}, +{ -499, -499, -499, -499, -499}, +{ -989, -989, -989, -989, -989}, +{ -789, -789, -789, -789, -789}}, +/* @.CG..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.CU..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -719, -719, -719, -719, -719}, +{ -989, -989, -989, -989, -989}, +{ -909, -909, -909, -909, -909}}}, +/* @.G@..CG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GA..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.GC..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -999, -999, -999, -999, -999}, +{ -499, -499, -499, -499, -499}, +{ -989, -989, -989, -989, -989}, +{ -789, -789, -789, -789, -789}}, +/* @.GG..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.GU..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -719, -719, -719, -719, -719}, +{ -989, -989, -989, -989, -989}, +{ -909, -909, -909, -909, -909}}}, +/* @.U@..CG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UA..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.UC..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -999, -999, -999, -999, -999}, +{ -499, -499, -499, -499, -499}, +{ -989, -989, -989, -989, -989}, +{ -789, -789, -789, -789, -789}}, +/* @.UG..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -569, -569, -569, -569, -569}, +{ -989, -989, -989, -989, -989}, +{ -859, -859, -859, -859, -859}}, +/* @.UU..CG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1079,-1079,-1079,-1079,-1079}, +{ -719, -719, -719, -719, -719}, +{ -989, -989, -989, -989, -989}, +{ -909, -909, -909, -909, -909}}}}, +/* @.@@..GC */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@A..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -569, -569, -569, -569, -569}, +{ -769, -769, -769, -769, -769}, +{ -759, -759, -759, -759, -759}, +{ -549, -549, -549, -549, -549}}, +/* @.@C..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -359, -359, -359, -359, -359}, +{ -789, -789, -789, -789, -789}, +{ -549, -549, -549, -549, -549}}, +/* @.@G..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -609, -609, -609, -609, -609}, +{ -359, -359, -359, -359, -359}, +{ -669, -669, -669, -669, -669}, +{ -549, -549, -549, -549, -549}}, +/* @.@U..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -439, -439, -439, -439, -439}, +{ -789, -789, -789, -789, -789}, +{ -619, -619, -619, -619, -619}}}, +/* @.A@..GC */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AA..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -569, -569, -569, -569, -569}, +{ -769, -769, -769, -769, -769}, +{ -759, -759, -759, -759, -759}, +{ -549, -549, -549, -549, -549}}, +/* @.AC..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -359, -359, -359, -359, -359}, +{ -789, -789, -789, -789, -789}, +{ -549, -549, -549, -549, -549}}, +/* @.AG..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -609, -609, -609, -609, -609}, +{ -359, -359, -359, -359, -359}, +{ -669, -669, -669, -669, -669}, +{ -549, -549, -549, -549, -549}}, +/* @.AU..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -439, -439, -439, -439, -439}, +{ -789, -789, -789, -789, -789}, +{ -619, -619, -619, -619, -619}}}, +/* @.C@..GC */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CA..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -569, -569, -569, -569, -569}, +{ -769, -769, -769, -769, -769}, +{ -759, -759, -759, -759, -759}, +{ -549, -549, -549, -549, -549}}, +/* @.CC..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -359, -359, -359, -359, -359}, +{ -789, -789, -789, -789, -789}, +{ -549, -549, -549, -549, -549}}, +/* @.CG..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -609, -609, -609, -609, -609}, +{ -359, -359, -359, -359, -359}, +{ -669, -669, -669, -669, -669}, +{ -549, -549, -549, -549, -549}}, +/* @.CU..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -439, -439, -439, -439, -439}, +{ -789, -789, -789, -789, -789}, +{ -619, -619, -619, -619, -619}}}, +/* @.G@..GC */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GA..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -569, -569, -569, -569, -569}, +{ -769, -769, -769, -769, -769}, +{ -759, -759, -759, -759, -759}, +{ -549, -549, -549, -549, -549}}, +/* @.GC..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -359, -359, -359, -359, -359}, +{ -789, -789, -789, -789, -789}, +{ -549, -549, -549, -549, -549}}, +/* @.GG..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -609, -609, -609, -609, -609}, +{ -359, -359, -359, -359, -359}, +{ -669, -669, -669, -669, -669}, +{ -549, -549, -549, -549, -549}}, +/* @.GU..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -439, -439, -439, -439, -439}, +{ -789, -789, -789, -789, -789}, +{ -619, -619, -619, -619, -619}}}, +/* @.U@..GC */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UA..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -569, -569, -569, -569, -569}, +{ -769, -769, -769, -769, -769}, +{ -759, -759, -759, -759, -759}, +{ -549, -549, -549, -549, -549}}, +/* @.UC..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -359, -359, -359, -359, -359}, +{ -789, -789, -789, -789, -789}, +{ -549, -549, -549, -549, -549}}, +/* @.UG..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -609, -609, -609, -609, -609}, +{ -359, -359, -359, -359, -359}, +{ -669, -669, -669, -669, -669}, +{ -549, -549, -549, -549, -549}}, +/* @.UU..GC */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -929, -929, -929, -929, -929}, +{ -439, -439, -439, -439, -439}, +{ -789, -789, -789, -789, -789}, +{ -619, -619, -619, -619, -619}}}}, +/* @.@@..GU */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@A..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.@C..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.@G..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.@U..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.A@..GU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AA..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.AC..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.AG..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.AU..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.C@..GU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CA..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.CC..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.CG..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.CU..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.G@..GU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GA..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.GC..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.GG..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.GU..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.U@..GU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UA..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.UC..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.UG..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.UU..GU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}}, +/* @.@@..UG */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@A..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -769, -769, -769, -769, -769}, +{ -529, -529, -529, -529, -529}, +{ -709, -709, -709, -709, -709}, +{ -599, -599, -599, -599, -599}}, +/* @.@C..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -839, -839, -839, -839, -839}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -489, -489, -489, -489, -489}}, +/* @.@G..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1009,-1009,-1009,-1009,-1009}, +{ -409, -409, -409, -409, -409}, +{ -969, -969, -969, -969, -969}, +{ -599, -599, -599, -599, -599}}, +/* @.@U..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -859, -859, -859, -859, -859}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -409, -409, -409, -409, -409}}}, +/* @.A@..UG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AA..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -769, -769, -769, -769, -769}, +{ -529, -529, -529, -529, -529}, +{ -709, -709, -709, -709, -709}, +{ -599, -599, -599, -599, -599}}, +/* @.AC..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -839, -839, -839, -839, -839}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -489, -489, -489, -489, -489}}, +/* @.AG..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1009,-1009,-1009,-1009,-1009}, +{ -409, -409, -409, -409, -409}, +{ -969, -969, -969, -969, -969}, +{ -599, -599, -599, -599, -599}}, +/* @.AU..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -859, -859, -859, -859, -859}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -409, -409, -409, -409, -409}}}, +/* @.C@..UG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CA..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -769, -769, -769, -769, -769}, +{ -529, -529, -529, -529, -529}, +{ -709, -709, -709, -709, -709}, +{ -599, -599, -599, -599, -599}}, +/* @.CC..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -839, -839, -839, -839, -839}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -489, -489, -489, -489, -489}}, +/* @.CG..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1009,-1009,-1009,-1009,-1009}, +{ -409, -409, -409, -409, -409}, +{ -969, -969, -969, -969, -969}, +{ -599, -599, -599, -599, -599}}, +/* @.CU..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -859, -859, -859, -859, -859}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -409, -409, -409, -409, -409}}}, +/* @.G@..UG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GA..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -769, -769, -769, -769, -769}, +{ -529, -529, -529, -529, -529}, +{ -709, -709, -709, -709, -709}, +{ -599, -599, -599, -599, -599}}, +/* @.GC..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -839, -839, -839, -839, -839}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -489, -489, -489, -489, -489}}, +/* @.GG..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1009,-1009,-1009,-1009,-1009}, +{ -409, -409, -409, -409, -409}, +{ -969, -969, -969, -969, -969}, +{ -599, -599, -599, -599, -599}}, +/* @.GU..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -859, -859, -859, -859, -859}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -409, -409, -409, -409, -409}}}, +/* @.U@..UG */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UA..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -769, -769, -769, -769, -769}, +{ -529, -529, -529, -529, -529}, +{ -709, -709, -709, -709, -709}, +{ -599, -599, -599, -599, -599}}, +/* @.UC..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -839, -839, -839, -839, -839}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -489, -489, -489, -489, -489}}, +/* @.UG..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{-1009,-1009,-1009,-1009,-1009}, +{ -409, -409, -409, -409, -409}, +{ -969, -969, -969, -969, -969}, +{ -599, -599, -599, -599, -599}}, +/* @.UU..UG */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -859, -859, -859, -859, -859}, +{ -529, -529, -529, -529, -529}, +{ -859, -859, -859, -859, -859}, +{ -409, -409, -409, -409, -409}}}}, +/* @.@@..AU */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@A..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.@C..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.@G..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.@U..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.A@..AU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AA..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.AC..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.AG..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.AU..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.C@..AU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CA..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.CC..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.CG..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.CU..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.G@..AU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GA..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.GC..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.GG..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.GU..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}, +/* @.U@..AU */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UA..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -479, -479, -479, -479, -479}, +{ -309, -309, -309, -309, -309}, +{ -389, -389, -389, -389, -389}, +{ -379, -379, -379, -379, -379}}, +/* @.UC..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.UG..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}, +/* @.UU..AU */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -649, -649, -649, -649, -649}, +{ -289, -289, -289, -289, -289}, +{ -739, -739, -739, -739, -739}, +{ -379, -379, -379, -379, -379}}}}, +/* @.@@..UA */ +{{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@A..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -449, -449, -449, -449, -449}, +{ -479, -479, -479, -479, -479}, +{ -429, -429, -429, -429, -429}, +{ -329, -329, -329, -329, -329}}, +/* @.@C..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -679, -679, -679, -679, -679}, +{ -559, -559, -559, -559, -559}, +{ -729, -729, -729, -729, -729}, +{ -189, -189, -189, -189, -189}}, +/* @.@G..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -939, -939, -939, -939, -939}, +{ -249, -249, -249, -249, -249}, +{ -939, -939, -939, -939, -939}, +{ -329, -329, -329, -329, -329}}, +/* @.@U..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -639, -639, -639, -639, -639}, +{ -229, -229, -229, -229, -229}, +{ -729, -729, -729, -729, -729}, +{ -190, -190, -190, -190, -190}}}, +/* @.A@..UA */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AA..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -449, -449, -449, -449, -449}, +{ -479, -479, -479, -479, -479}, +{ -429, -429, -429, -429, -429}, +{ -329, -329, -329, -329, -329}}, +/* @.AC..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -679, -679, -679, -679, -679}, +{ -559, -559, -559, -559, -559}, +{ -729, -729, -729, -729, -729}, +{ -189, -189, -189, -189, -189}}, +/* @.AG..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -939, -939, -939, -939, -939}, +{ -249, -249, -249, -249, -249}, +{ -939, -939, -939, -939, -939}, +{ -329, -329, -329, -329, -329}}, +/* @.AU..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -639, -639, -639, -639, -639}, +{ -229, -229, -229, -229, -229}, +{ -729, -729, -729, -729, -729}, +{ -190, -190, -190, -190, -190}}}, +/* @.C@..UA */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CA..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -449, -449, -449, -449, -449}, +{ -479, -479, -479, -479, -479}, +{ -429, -429, -429, -429, -429}, +{ -329, -329, -329, -329, -329}}, +/* @.CC..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -679, -679, -679, -679, -679}, +{ -559, -559, -559, -559, -559}, +{ -729, -729, -729, -729, -729}, +{ -189, -189, -189, -189, -189}}, +/* @.CG..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -939, -939, -939, -939, -939}, +{ -249, -249, -249, -249, -249}, +{ -939, -939, -939, -939, -939}, +{ -329, -329, -329, -329, -329}}, +/* @.CU..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -639, -639, -639, -639, -639}, +{ -229, -229, -229, -229, -229}, +{ -729, -729, -729, -729, -729}, +{ -190, -190, -190, -190, -190}}}, +/* @.G@..UA */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GA..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -449, -449, -449, -449, -449}, +{ -479, -479, -479, -479, -479}, +{ -429, -429, -429, -429, -429}, +{ -329, -329, -329, -329, -329}}, +/* @.GC..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -679, -679, -679, -679, -679}, +{ -559, -559, -559, -559, -559}, +{ -729, -729, -729, -729, -729}, +{ -189, -189, -189, -189, -189}}, +/* @.GG..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -939, -939, -939, -939, -939}, +{ -249, -249, -249, -249, -249}, +{ -939, -939, -939, -939, -939}, +{ -329, -329, -329, -329, -329}}, +/* @.GU..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -639, -639, -639, -639, -639}, +{ -229, -229, -229, -229, -229}, +{ -729, -729, -729, -729, -729}, +{ -190, -190, -190, -190, -190}}}, +/* @.U@..UA */ +{{{ DEF, DEF, DEF, DEF, DEF}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UA..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -449, -449, -449, -449, -449}, +{ -479, -479, -479, -479, -479}, +{ -429, -429, -429, -429, -429}, +{ -329, -329, -329, -329, -329}}, +/* @.UC..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -679, -679, -679, -679, -679}, +{ -559, -559, -559, -559, -559}, +{ -729, -729, -729, -729, -729}, +{ -189, -189, -189, -189, -189}}, +/* @.UG..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -939, -939, -939, -939, -939}, +{ -249, -249, -249, -249, -249}, +{ -939, -939, -939, -939, -939}, +{ -329, -329, -329, -329, -329}}, +/* @.UU..UA */ +{{ DEF, DEF, DEF, DEF, DEF}, +{ -639, -639, -639, -639, -639}, +{ -229, -229, -229, -229, -229}, +{ -729, -729, -729, -729, -729}, +{ -190, -190, -190, -190, -190}}}}, +/* @.@@.. @ */ +{{{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@A.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@C.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@G.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.@U.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}}, +/* @.A@.. @ */ +{{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AA.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AC.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AG.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.AU.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}}, +/* @.C@.. @ */ +{{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CA.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CC.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CG.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.CU.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}}, +/* @.G@.. @ */ +{{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GA.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GC.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GG.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.GU.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}}, +/* @.U@.. @ */ +{{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UA.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UC.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UG.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}, +/* @.UU.. @ */ +{{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}, +{ -100, -100, -100, -100, -100}}}}}}; + + diff --git a/include/PS_dot.h b/include/PS_dot.h new file mode 100644 --- /dev/null +++ b/include/PS_dot.h @@ -0,0 +1,197 @@ +#ifndef __VIENNA_RNA_PACKAGE_PS_DOT_H__ +#define __VIENNA_RNA_PACKAGE_PS_DOT_H__ + +#include "data_structures.h" +#include "plot_layouts.h" + +#ifdef __GNUC__ +#define DEPRECATED(func) func __attribute__ ((deprecated)) +#else +#define DEPRECATED(func) func +#endif + +/** + * \file PS_dot.h + * \brief Various functions for plotting RNA secondary structures, dot-plots and other + * visualizations + */ + +/* write PostScript drawing of structure to file with annotation */ +int PS_rna_plot_snoop_a(char *string, + char *structure, + char *ssfile, + int *relative_access, + const char *seqs[]); + +/** + * \brief Produce a secondary structure graph in PostScript and write it to 'filename'. + * + * Note that this function has changed from previous versions + * and now expects the structure to be plotted in dot-bracket notation as an + * argument. It does not make use of the global #base_pair array anymore. + * + * \param string The RNA sequence + * \param structure The secondary structure in dot-bracket notation + * \param file The filename of the postscript output + * \return 1 on success, 0 otherwise + */ +int PS_rna_plot(char *string, + char *structure, + char *file); + +/** + * \brief Produce a secondary structure graph in PostScript including additional + * annotation macros and write it to 'filename' + * + * Same as PS_rna_plot() but adds extra PostScript macros for various + * annotations (see generated PS code). The 'pre' and 'post' + * variables contain PostScript code that is verbatim copied in the + * resulting PS file just before and after the structure plot. + * If both arguments ('pre' and 'post') are NULL, no additional macros will + * be printed into the PostScript. + * + * \param string The RNA sequence + * \param structure The secondary structure in dot-bracket notation + * \param file The filename of the postscript output + * \param pre PostScript code to appear before the secondary structure plot + * \param post PostScript code to appear after the secondary structure plot + * \return 1 on success, 0 otherwise + */ +int PS_rna_plot_a(char *string, + char *structure, + char *file, + char *pre, + char *post); + +int PS_rna_plot_a_gquad(char *string, + char *structure, + char *ssfile, + char *pre, + char *post); + +/** + * \brief Produce a secondary structure graph in Graph Meta Language (gml) and write it to a file + * + * If 'option' is an uppercase letter the RNA sequence is used to label nodes, if 'option' equals + * \a 'X' or \a 'x' the resulting file will coordinates for an initial layout of the graph. + * + * \param string The RNA sequence + * \param structure The secondary structure in dot-bracket notation + * \param ssfile The filename of the gml output + * \param option The option flag + * \return 1 on success, 0 otherwise + */ +int gmlRNA( char *string, + char *structure, + char *ssfile, + char option); + +/** + * \brief Produce a secondary structure graph in SStructView format + * + * Write coord file for SStructView + * + * \param string The RNA sequence + * \param structure The secondary structure in dot-bracket notation + * \param ssfile The filename of the ssv output + * \return 1 on success, 0 otherwise + */ +int ssv_rna_plot( char *string, + char *structure, + char *ssfile); + +/** + * \brief Produce a secondary structure plot in SVG format and write it to a file + * + * \param string The RNA sequence + * \param structure The secondary structure in dot-bracket notation + * \param ssfile The filename of the svg output + * \return 1 on success, 0 otherwise + */ +int svg_rna_plot( char *string, + char *structure, + char *ssfile); + +/** + * \brief Produce a secondary structure plot for further editing in XRNA + * + * \param string The RNA sequence + * \param structure The secondary structure in dot-bracket notation + * \param ssfile The filename of the xrna output + * \return 1 on success, 0 otherwise + */ +int xrna_plot(char *string, + char *structure, + char *ssfile); + +int PS_color_dot_plot(char *string, + cpair *pi, + char *filename); + +int PS_color_dot_plot_turn( char *seq, + cpair *pi, + char *filename, + int winSize); + +/** + * \brief Produce a postscript dot-plot from two pair lists + * + * This function reads two plist structures (e.g. base pair probabilities and a secondary structure) + * as produced by assign_plist_from_pr() and assign_plist_from_db() and produces a postscript + * "dot plot" that is written to 'filename'.\n + * Using base pair probabilities in the first and mfe structure in the second plist, the resulting + * "dot plot" represents each base pairing probability by a square of corresponding area in a upper + * triangle matrix. The lower part of the matrix contains the minimum free energy structure. + * + * \see assign_plist_from_pr(), assign_plist_from_db() + * + * \param seq The RNA sequence + * \param filename A filename for the postscript output + * \param pl The base pair probability pairlist + * \param mf The mfe secondary structure pairlist + * \param comment A comment + * \return 1 if postscript was successfully written, 0 otherwise + */ +int PS_dot_plot_list( char *seq, + char *filename, + plist *pl, + plist *mf, + char *comment); + +int PS_dot_plot_turn( char *seq, + struct plist *pl, + char *filename, + int winSize); + +int PS_color_aln( const char *structure, + const char *filename, + const char *seqs[], + const char *names[]); + +/** + * PS_color_aln for duplexes +*/ +int aliPS_color_aln(const char *structure, + const char *filename, + const char *seqs[], + const char *names[]); + + +/** + * Wrapper to PS_dot_plot_list + * + * \brief Produce postscript dot-plot + * + * Reads base pair probabilities produced by pf_fold() from the + * global array #pr and the pair list #base_pair produced by + * fold() and produces a postscript "dot plot" that is written to + * 'filename'. The "dot plot" represents each base pairing + * probability by a square of corresponding area in a upper triangle + * matrix. The lower part of the matrix contains the minimum free energy + * \note DO NOT USE THIS FUNCTION ANYMORE SINCE IT IS NOT THREADSAFE + * + * \deprecated This function is deprecated and will be removed soon! Use \ref PS_dot_plot_list() instead! + */ +DEPRECATED(int PS_dot_plot( char *string, + char *file)); +#endif diff --git a/include/aln_util.h b/include/aln_util.h new file mode 100644 --- /dev/null +++ b/include/aln_util.h @@ -0,0 +1,10 @@ +#ifndef __VIENNA_RNA_PACKAGE_ALN_UTIL_H__ +#define __VIENNA_RNA_PACKAGE_ALN_UTIL_H__ + +int read_clustal( FILE *clust, + char *AlignedSeqs[], + char *names[]); +/*@only@*/ /*@notnull@*/ char *consensus(const char *AS[]); +/*@only@*/ /*@notnull@*/ char *consens_mis(const char *AS[]); + +#endif diff --git a/include/cofold.h b/include/cofold.h new file mode 100644 --- /dev/null +++ b/include/cofold.h @@ -0,0 +1,182 @@ +#ifndef __VIENNA_RNA_PACKAGE_COFOLD_H__ +#define __VIENNA_RNA_PACKAGE_COFOLD_H__ + +#include "data_structures.h" + +#ifdef __GNUC__ +#define DEPRECATED(func) func __attribute__ ((deprecated)) +#else +#define DEPRECATED(func) func +#endif + +/** + * \addtogroup cofold + * \brief Predict structures formed by two molecules upon hybridization. + * + * The function of an RNA molecule often depends on its interaction with + * other RNAs. The following routines therefore allow to predict structures + * formed by two RNA molecules upon hybridization.\n + * One approach to co-folding two RNAs consists of concatenating the two + * sequences and keeping track of the concatenation point in all energy + * evaluations. Correspondingly, many of the cofold() and + * co_pf_fold() routines below take one sequence string as argument + * and use the the global variable #cut_point to mark the concatenation + * point. Note that while the RNAcofold program uses the '&' character + * to mark the chain break in its input, you should not use an '&' when using + * the library routines (set #cut_point instead).\n + * In a second approach to co-folding two RNAs, cofolding is seen as a + * stepwise process. In the first step the probability of an unpaired region + * is calculated and in a second step this probability of an unpaired region + * is multiplied with the probability of an interaction between the two RNAs. + * This approach is implemented for the interaction between a long + * target sequence and a short ligand RNA. Function pf_unstru() calculates + * the partition function over all unpaired regions in the input + * sequence. Function pf_interact(), which calculates the + * partition function over all possible interactions between two + * sequences, needs both sequence as separate strings as input. + * + */ + +/** + * \addtogroup mfe_cofold + * @{ + * \file cofold.h + * + * \brief MFE version of cofolding routines + * + * This file includes (almost) all function declarations within the RNAlib that are related to + * MFE Cofolding... + * This also includes the Zuker suboptimals calculations, since they are implemented using the cofold + * routines. + */ + +/** + * \brief Compute the minimum free energy of two interacting RNA molecules + * + * The code is analog to the fold() function. If #cut_point ==-1 results + * should be the same as with fold(). + * + * \ingroup mfe_cofold + * + * \param sequence The two sequences concatenated + * \param structure Will hold the barcket dot structure of the dimer molecule + * \return minimum free energy of the structure + */ +float cofold( const char *sequence, + char *structure); + +/** + * \brief Compute the minimum free energy of two interacting RNA molecules + * + */ +float cofold_par( const char *string, + char *structure, + paramT *parameters, + int is_constrained); + +/** + * \brief Free memory occupied by cofold() + */ +void free_co_arrays(void); + +/** + * \brief Recalculate parameters + */ +void update_cofold_params(void); + +void update_cofold_params_par(paramT *parameters); + + +/** + * \brief Export the arrays of partition function cofold (with gquadruplex support) + * + * Export the cofold arrays for use e.g. in the concentration + * Computations or suboptimal secondary structure backtracking + * + * \param f5_p A pointer to the 'f5' array, i.e. array conatining best free energy in interval [1,j] + * \param c_p A pointer to the 'c' array, i.e. array containing best free energy in interval [i,j] given that i pairs with j + * \param fML_p A pointer to the 'M' array, i.e. array containing best free energy in interval [i,j] for any multiloop segment with at least one stem + * \param fM1_p A pointer to the 'M1' array, i.e. array containing best free energy in interval [i,j] for multiloop segment with exactly one stem + * \param fc_p A pointer to the 'fc' array, i.e. array ... + * \param ggg_p A pointer to the 'ggg' array, i.e. array containing best free energy of a gquadruplex delimited by [i,j] + * \param indx_p A pointer to the indexing array used for accessing the energy matrices + * \param ptype_p A pointer to the ptype array containing the base pair types for each possibility (i,j) + */ +void export_cofold_arrays_gq( int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **fc_p, + int **ggg_p, + int **indx_p, + char **ptype_p); + +/** + * \brief Export the arrays of partition function cofold + * + * Export the cofold arrays for use e.g. in the concentration + * Computations or suboptimal secondary structure backtracking + * + * \param f5_p A pointer to the 'f5' array, i.e. array conatining best free energy in interval [1,j] + * \param c_p A pointer to the 'c' array, i.e. array containing best free energy in interval [i,j] given that i pairs with j + * \param fML_p A pointer to the 'M' array, i.e. array containing best free energy in interval [i,j] for any multiloop segment with at least one stem + * \param fM1_p A pointer to the 'M1' array, i.e. array containing best free energy in interval [i,j] for multiloop segment with exactly one stem + * \param fc_p A pointer to the 'fc' array, i.e. array ... + * \param indx_p A pointer to the indexing array used for accessing the energy matrices + * \param ptype_p A pointer to the ptype array containing the base pair types for each possibility (i,j) + */ +void export_cofold_arrays(int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **fc_p, + int **indx_p, + char **ptype_p); + + +/** + * @} + */ + +/** + * \brief Compute Zuker type suboptimal structures + * + * Compute Suboptimal structures according to M. Zuker, i.e. for every + * possible base pair the minimum energy structure containing the resp. base pair. + * Returns a list of these structures and their energies. + * + * \ingroup subopt_zuker + * + * \param string RNA sequence + * \return List of zuker suboptimal structures + */ +SOLUTION *zukersubopt(const char *string); + +/** + * \brief Compute Zuker type suboptimal structures + * + * \ingroup subopt_zuker + * + */ +SOLUTION *zukersubopt_par( const char *string, + paramT *parameters); + +/** + * \brief get_monomer_free_energies + * + * Export monomer free energies out of cofold arrays + * + * \param e1 A pointer to a variable where the energy of molecule A will be written to + * \param e2 A pointer to a variable where the energy of molecule B will be written to + */ +void get_monomere_mfes( float *e1, + float *e2); + + +/** + * allocate arrays for folding + * \deprecated{This function is obsolete and will be removed soon!} + */ +DEPRECATED(void initialize_cofold(int length)); + +#endif diff --git a/include/config.h b/include/config.h new file mode 100644 --- /dev/null +++ b/include/config.h @@ -0,0 +1,163 @@ +/* config.h. Generated from config.h.in by configure. */ +/* config.h.in. Generated from configure.ac by autoheader. */ + +/* Define to 1 if you have the `erand48' function. */ +#define HAVE_ERAND48 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_FLOAT_H 1 + +/* Define to 1 if you have the `floor' function. */ +#define HAVE_FLOOR 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_INTTYPES_H 1 + +/* Define to 1 if you have the `m' library (-lm). */ +#define HAVE_LIBM 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_LIMITS_H 1 + +/* Define to 1 if your system has a GNU libc compatible `malloc' function, and + to 0 otherwise. */ +#define HAVE_MALLOC 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_MALLOC_H 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_MATH_H 1 + +/* Define to 1 if you have the `memmove' function. */ +#define HAVE_MEMMOVE 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_MEMORY_H 1 + +/* Define to 1 if you have the `memset' function. */ +#define HAVE_MEMSET 1 + +/* Define to 1 if you have the `pow' function. */ +#define HAVE_POW 1 + +/* Define to 1 if your system has a GNU libc compatible `realloc' function, + and to 0 otherwise. */ +#define HAVE_REALLOC 1 + +/* Define to 1 if you have the `rint' function. */ +#define HAVE_RINT 1 + +/* Define to 1 if you have the `sqrt' function. */ +#define HAVE_SQRT 1 + +/* Define to 1 if stdbool.h conforms to C99. */ +#define HAVE_STDBOOL_H 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_STDINT_H 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_STDLIB_H 1 + +/* Define to 1 if you have the `strchr' function. */ +#define HAVE_STRCHR 1 + +/* Define to 1 if you have the `strdup' function. */ +#define HAVE_STRDUP 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_STRINGS_H 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_STRING_H 1 + +/* Define to 1 if you have the `strrchr' function. */ +#define HAVE_STRRCHR 1 + +/* Define to 1 if you have the `strstr' function. */ +#define HAVE_STRSTR 1 + +/* Define to 1 if you have the `strtol' function. */ +#define HAVE_STRTOL 1 + +/* Define to 1 if you have the `strtoul' function. */ +#define HAVE_STRTOUL 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_SYS_STAT_H 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_SYS_TYPES_H 1 + +/* Define to 1 if you have the header file. */ +#define HAVE_UNISTD_H 1 + +/* Define to 1 if the system has the type `_Bool'. */ +#define HAVE__BOOL 1 + +/* Define to 1 if your C compiler doesn't accept -c and -o together. */ +/* #undef NO_MINUS_C_MINUS_O */ + +/* Name of package */ +#define PACKAGE "ViennaRNA" + +/* Define to the address where bug reports for this package should be sent. */ +#define PACKAGE_BUGREPORT "rna@tbi.univie.ac.at" + +/* Define to the full name of this package. */ +#define PACKAGE_NAME "ViennaRNA" + +/* Define to the full name and version of this package. */ +#define PACKAGE_STRING "ViennaRNA 2.1.5" + +/* Define to the one symbol short name of this package. */ +#define PACKAGE_TARNAME "ViennaRNA" + +/* Define to the home page for this package. */ +#define PACKAGE_URL "http://www.tbi.univie.ac.a/~ivo/RNA" + +/* Define to the version of this package. */ +#define PACKAGE_VERSION "2.1.5" + +/* Define to 1 if you have the ANSI C header files. */ +#define STDC_HEADERS 1 + +/* only for gcc */ +#define UNUSED __attribute__ ((unused)) + +/* Compute z-scores for RNALfold */ +#define USE_SVM 1 + +/* Version number of package */ +#define VERSION "2.1.5" + +/* Analyse{Dists,Seqs} */ +#define WITH_CLUSTER 1 + +/* Define if using the dmalloc debugging malloc package */ +/* #undef WITH_DMALLOC */ + +/* Create the perl interface to RNAlib */ +#define WITH_PERL_INTERFACE 1 + +/* Create the python interface to RNAlib */ +/* #undef WITH_PYTHON_INTERFACE */ + +/* Define to empty if `const' does not conform to ANSI C. */ +/* #undef const */ + +/* Define to `__inline__' or `__inline' if that's what the C compiler + calls it, or to nothing if 'inline' is not supported under any name. */ +#ifndef __cplusplus +/* #undef inline */ +#endif + +/* Define to rpl_malloc if the replacement function should be used. */ +/* #undef malloc */ + +/* Define to rpl_realloc if the replacement function should be used. */ +/* #undef realloc */ + +/* Define to `unsigned int' if does not define. */ +/* #undef size_t */ diff --git a/include/data_structures.h b/include/data_structures.h new file mode 100644 --- /dev/null +++ b/include/data_structures.h @@ -0,0 +1,774 @@ +#ifndef __VIENNA_RNA_PACKAGE_DATA_STRUCTURES_H__ +#define __VIENNA_RNA_PACKAGE_DATA_STRUCTURES_H__ + +#include "energy_const.h" +/** + * \file data_structures.h + * \brief All datastructures and typedefs shared among the Vienna RNA Package can be found here + */ + +/* to use floats instead of doubles in pf_fold() comment next line */ +#define LARGE_PF +#ifdef LARGE_PF +#define FLT_OR_DBL double +#else +#define FLT_OR_DBL float +#endif + +#ifndef NBASES +#define NBASES 8 +#endif + +#ifndef MAXALPHA +/** + * \brief Maximal length of alphabet + */ +#define MAXALPHA 20 +#endif + +/** + * \brief Maximum density of states discretization for subopt + */ +#define MAXDOS 1000 + +#define VRNA_GQUAD_MAX_STACK_SIZE 7 +#define VRNA_GQUAD_MIN_STACK_SIZE 2 +#define VRNA_GQUAD_MAX_LINKER_LENGTH 15 +#define VRNA_GQUAD_MIN_LINKER_LENGTH 1 +#define VRNA_GQUAD_MIN_BOX_SIZE ((4*VRNA_GQUAD_MIN_STACK_SIZE)+(3*VRNA_GQUAD_MIN_LINKER_LENGTH)) +#define VRNA_GQUAD_MAX_BOX_SIZE ((4*VRNA_GQUAD_MAX_STACK_SIZE)+(3*VRNA_GQUAD_MAX_LINKER_LENGTH)) + + +/* +* ############################################################ +* Here are the type definitions of various datastructures +* shared among the Vienna RNA Package +* ############################################################ +*/ + +/** + * \brief this datastructure is used as input parameter in functions of PS_dot.h and others + */ +typedef struct plist { + int i; + int j; + float p; + int type; +} plist; + +/** + * \brief this datastructure is used as input parameter in functions of PS_dot.c + */ +typedef struct cpair { + int i,j,mfe; + float p, hue, sat; +} cpair; + +/** + * \brief this is a workarround for the SWIG Perl Wrapper RNA plot function + * that returns an array of type COORDINATE + */ +typedef struct { + float X; /* X coords */ + float Y; /* Y coords */ +} COORDINATE; + +/** + * \brief Stack of partial structures for backtracking + */ +typedef struct sect { + int i; + int j; + int ml; +} sect; + +/** + * \brief Base pair + */ +typedef struct bondT { + unsigned int i; + unsigned int j; +} bondT; + +/** + * \brief Base pair with associated energy + */ +typedef struct bondTEn { + int i; + int j; + int energy; +} bondTEn; + +/** + * \brief The data structure that contains the complete model details used throughout the calculations + * + */ +typedef struct{ + int dangles; /**< \brief Specifies the dangle model used in any energy evaluation (0,1,2 or 3) + \note Some function do not implement all dangle model but only a subset of + (0,1,2,3). Read the documentaion of the particular recurrences or + energy evaluation function for information about the provided dangle + model. + */ + int special_hp; /**< \brief Include special hairpin contributions for tri, tetra and hexaloops */ + int noLP; /**< \brief Only consider canonical structures, i.e. no 'lonely' base pairs */ + int noGU; /**< \brief Do not allow GU pairs */ + int noGUclosure; /**< \brief Do not allow loops to be closed by GU pair */ + int logML; /**< \brief Use logarithmic scaling for multi loops */ + int circ; /**< \brief Assume molecule to be circular */ + int gquad; /**< \brief Include G-quadruplexes in structure prediction */ +} model_detailsT; + +/** + * \brief The datastructure that contains temperature scaled energy parameters. + */ +typedef struct{ + int id; + int stack[NBPAIRS+1][NBPAIRS+1]; + int hairpin[31]; + int bulge[MAXLOOP+1]; + int internal_loop[MAXLOOP+1]; + int mismatchExt[NBPAIRS+1][5][5]; + int mismatchI[NBPAIRS+1][5][5]; + int mismatch1nI[NBPAIRS+1][5][5]; + int mismatch23I[NBPAIRS+1][5][5]; + int mismatchH[NBPAIRS+1][5][5]; + int mismatchM[NBPAIRS+1][5][5]; + int dangle5[NBPAIRS+1][5]; + int dangle3[NBPAIRS+1][5]; + int int11[NBPAIRS+1][NBPAIRS+1][5][5]; + int int21[NBPAIRS+1][NBPAIRS+1][5][5][5]; + int int22[NBPAIRS+1][NBPAIRS+1][5][5][5][5]; + int ninio[5]; + double lxc; + int MLbase; + int MLintern[NBPAIRS+1]; + int MLclosing; + int TerminalAU; + int DuplexInit; + int Tetraloop_E[200]; + char Tetraloops[1401]; + int Triloop_E[40]; + char Triloops[241]; + int Hexaloop_E[40]; + char Hexaloops[1801]; + int TripleC; + int MultipleCA; + int MultipleCB; + int gquad [VRNA_GQUAD_MAX_STACK_SIZE + 1] + [3*VRNA_GQUAD_MAX_LINKER_LENGTH + 1]; + + double temperature; /**< \brief Temperature used for loop contribution scaling */ + + model_detailsT model_details; /**< \brief Model details to be used in the recursions */ + +} paramT; + +/** + * \brief The datastructure that contains temperature scaled Boltzmann weights of the energy parameters. + */ +typedef struct{ + int id; + double expstack[NBPAIRS+1][NBPAIRS+1]; + double exphairpin[31]; + double expbulge[MAXLOOP+1]; + double expinternal[MAXLOOP+1]; + double expmismatchExt[NBPAIRS+1][5][5]; + double expmismatchI[NBPAIRS+1][5][5]; + double expmismatch23I[NBPAIRS+1][5][5]; + double expmismatch1nI[NBPAIRS+1][5][5]; + double expmismatchH[NBPAIRS+1][5][5]; + double expmismatchM[NBPAIRS+1][5][5]; + double expdangle5[NBPAIRS+1][5]; + double expdangle3[NBPAIRS+1][5]; + double expint11[NBPAIRS+1][NBPAIRS+1][5][5]; + double expint21[NBPAIRS+1][NBPAIRS+1][5][5][5]; + double expint22[NBPAIRS+1][NBPAIRS+1][5][5][5][5]; + double expninio[5][MAXLOOP+1]; + double lxc; + double expMLbase; + double expMLintern[NBPAIRS+1]; + double expMLclosing; + double expTermAU; + double expDuplexInit; + double exptetra[40]; + double exptri[40]; + double exphex[40]; + char Tetraloops[1401]; + double expTriloop[40]; + char Triloops[241]; + char Hexaloops[1801]; + double expTripleC; + double expMultipleCA; + double expMultipleCB; + double expgquad[VRNA_GQUAD_MAX_STACK_SIZE + 1] + [3*VRNA_GQUAD_MAX_LINKER_LENGTH + 1]; + + double kT; + double pf_scale; /**< \brief Scaling factor to avoid over-/underflows */ + + double temperature; /**< \brief Temperature used for loop contribution scaling */ + double alpha; /**< \brief Scaling factor for the thermodynamic temperature + \details This allows for temperature scaling in Boltzmann + factors independently from the energy contributions. + The resulting Boltzmann factors are then computed by + \f$ e^{-E/(\alpha \cdot K \cdot T)} \f$ + */ + + model_detailsT model_details; /**< \brief Model details to be used in the recursions */ + +} pf_paramT; + + + +/* +* ############################################################ +* SUBOPT data structures +* ############################################################ +*/ + + +/** + * \brief Base pair data structure used in subopt.c + */ +typedef struct { + int i; + int j; +} PAIR; + +/** + * \brief Sequence interval stack element used in subopt.c + */ +typedef struct { + int i; + int j; + int array_flag; +} INTERVAL; + +/** + * \brief Solution element from subopt.c + */ +typedef struct { + float energy; /**< \brief Free Energy of structure in kcal/mol */ + char *structure; /**< \brief Structure in dot-bracket notation */ +} SOLUTION; + +/* +* ############################################################ +* COFOLD data structures +* ############################################################ +*/ + +/** + * \brief + */ +typedef struct cofoldF { + /* free energies for: */ + double F0AB; /**< \brief Null model without DuplexInit */ + double FAB; /**< \brief all states with DuplexInit correction */ + double FcAB; /**< \brief true hybrid states only */ + double FA; /**< \brief monomer A */ + double FB; /**< \brief monomer B */ +} cofoldF; + +/** + * \brief + */ +typedef struct ConcEnt { + double A0; /**< \brief start concentration A */ + double B0; /**< \brief start concentration B */ + double ABc; /**< \brief End concentration AB */ + double AAc; + double BBc; + double Ac; + double Bc; +} ConcEnt; + +/** + * \brief + */ +typedef struct pairpro{ + struct plist *AB; + struct plist *AA; + struct plist *A; + struct plist *B; + struct plist *BB; +}pairpro; + +/** + * \brief A base pair info structure + * + * For each base pair (i,j) with i,j in [0, n-1] the structure lists: + * - its probability 'p' + * - an entropy-like measure for its well-definedness 'ent' + * - the frequency of each type of pair in 'bp[]' + * + 'bp[0]' contains the number of non-compatible sequences + * + 'bp[1]' the number of CG pairs, etc. + */ +typedef struct { + unsigned i; /**< \brief nucleotide position i */ + unsigned j; /**< \brief nucleotide position j */ + float p; /**< \brief Probability */ + float ent; /**< \brief Pseudo entropy for \f$ p(i,j) = S_i + S_j - p_ij*ln(p_ij) \f$ */ + short bp[8]; /**< \brief Frequencies of pair_types */ + char comp; /**< \brief 1 iff pair is in mfe structure */ +} pair_info; + + +/* +* ############################################################ +* FINDPATH data structures +* ############################################################ +*/ + +/** + * \brief + */ +typedef struct move { + int i; /* i,j>0 insert; i,j<0 delete */ + int j; + int when; /* 0 if still available, else resulting distance from start */ + int E; +} move_t; + +/** + * \brief + */ +typedef struct intermediate { + short *pt; /**< \brief pair table */ + int Sen; /**< \brief saddle energy so far */ + int curr_en; /**< \brief current energy */ + move_t *moves; /**< \brief remaining moves to target */ +} intermediate_t; + +/** + * \brief + */ +typedef struct path { + double en; + char *s; +} path_t; + +/* +* ############################################################ +* RNAup data structures +* ############################################################ +*/ + +/** + * \brief contributions to p_u + */ +typedef struct pu_contrib { + double **H; /**< \brief hairpin loops */ + double **I; /**< \brief interior loops */ + double **M; /**< \brief multi loops */ + double **E; /**< \brief exterior loop */ + int length; /**< \brief length of the input sequence */ + int w; /**< \brief longest unpaired region */ +} pu_contrib; + +/** + * \brief + */ +typedef struct interact { + double *Pi; /**< \brief probabilities of interaction */ + double *Gi; /**< \brief free energies of interaction */ + double Gikjl; /**< \brief full free energy for interaction between [k,i] k (k_max, l_max) */ + int *E_F5_rem; + int *E_F3_rem; + int *E_C_rem; + int *E_M_rem; + int *E_M1_rem; + int *E_M2_rem; + + int E_Fc_rem; + int E_FcH_rem; + int E_FcI_rem; + int E_FcM_rem; + +#ifdef COUNT_STATES + unsigned long ***N_F5; + unsigned long ***N_C; + unsigned long ***N_M; + unsigned long ***N_M1; +#endif +} TwoDfold_vars; + +/** + * \brief Solution element returned from TwoDpfoldList + * + * This element contains the partition function for the appropriate + * kappa (k), lambda (l) neighborhood + * The datastructure contains two integer attributes 'k' and 'l' + * as well as an attribute 'q' of type #FLT_OR_DBL + * + * A value of #INF in k denotes the end of a list + * + * \see TwoDpfoldList() + */ +typedef struct{ + int k; /**< \brief Distance to first reference */ + int l; /**< \brief Distance to second reference */ + FLT_OR_DBL q; /**< \brief partition function */ +} TwoDpfold_solution; + +/** + * \brief Variables compound for 2Dfold partition function folding + * + * \see get_TwoDpfold_variables(), get_TwoDpfold_variables_from_MFE(), + * destroy_TwoDpfold_variables(), TwoDpfoldList() + */ +typedef struct{ + + unsigned int alloc; + char *ptype; /**< \brief Precomputed array of pair types */ + char *sequence; /**< \brief The input sequence */ + short *S, *S1; /**< \brief The input sequences in numeric form */ + unsigned int maxD1; /**< \brief Maximum allowed base pair distance to first reference */ + unsigned int maxD2; /**< \brief Maximum allowed base pair distance to second reference */ + + double temperature; /* temperature in last call to scale_pf_params */ + double init_temp; /* temperature in last call to scale_pf_params */ + FLT_OR_DBL *scale; + FLT_OR_DBL pf_scale; + pf_paramT *pf_params; /* holds all [unscaled] pf parameters */ + + int *my_iindx; /**< \brief Index for moving in quadratic distancy dimensions */ + int *jindx; /**< \brief Index for moving in the triangular matrix qm1 */ + + short *reference_pt1; + short *reference_pt2; + + unsigned int *referenceBPs1; /**< \brief Matrix containing number of basepairs of reference structure1 in interval [i,j] */ + unsigned int *referenceBPs2; /**< \brief Matrix containing number of basepairs of reference structure2 in interval [i,j] */ + unsigned int *bpdist; /**< \brief Matrix containing base pair distance of reference structure 1 and 2 on interval [i,j] */ + + unsigned int *mm1; /**< \brief Maximum matching matrix, reference struct 1 disallowed */ + unsigned int *mm2; /**< \brief Maximum matching matrix, reference struct 2 disallowed */ + + int circ; + int dangles; + unsigned int seq_length; + + FLT_OR_DBL ***Q; + FLT_OR_DBL ***Q_B; + FLT_OR_DBL ***Q_M; + FLT_OR_DBL ***Q_M1; + FLT_OR_DBL ***Q_M2; + + FLT_OR_DBL **Q_c; + FLT_OR_DBL **Q_cH; + FLT_OR_DBL **Q_cI; + FLT_OR_DBL **Q_cM; + + int **l_min_values; + int **l_max_values; + int *k_min_values; + int *k_max_values; + + int **l_min_values_b; + int **l_max_values_b; + int *k_min_values_b; + int *k_max_values_b; + + int **l_min_values_m; + int **l_max_values_m; + int *k_min_values_m; + int *k_max_values_m; + + int **l_min_values_m1; + int **l_max_values_m1; + int *k_min_values_m1; + int *k_max_values_m1; + + int **l_min_values_m2; + int **l_max_values_m2; + int *k_min_values_m2; + int *k_max_values_m2; + + int *l_min_values_qc; + int *l_max_values_qc; + int k_min_values_qc; + int k_max_values_qc; + + int *l_min_values_qcH; + int *l_max_values_qcH; + int k_min_values_qcH; + int k_max_values_qcH; + + int *l_min_values_qcI; + int *l_max_values_qcI; + int k_min_values_qcI; + int k_max_values_qcI; + + int *l_min_values_qcM; + int *l_max_values_qcM; + int k_min_values_qcM; + int k_max_values_qcM; + + /* auxilary arrays for remaining set of coarse graining (k,l) > (k_max, l_max) */ + FLT_OR_DBL *Q_rem; + FLT_OR_DBL *Q_B_rem; + FLT_OR_DBL *Q_M_rem; + FLT_OR_DBL *Q_M1_rem; + FLT_OR_DBL *Q_M2_rem; + + FLT_OR_DBL Q_c_rem; + FLT_OR_DBL Q_cH_rem; + FLT_OR_DBL Q_cI_rem; + FLT_OR_DBL Q_cM_rem; + +} TwoDpfold_vars; + +#endif diff --git a/include/energy_const.h b/include/energy_const.h new file mode 100644 --- /dev/null +++ b/include/energy_const.h @@ -0,0 +1,33 @@ +#ifndef __VIENNA_RNA_PACKAGE_ENERGY_CONST_H__ +#define __VIENNA_RNA_PACKAGE_ENERGY_CONST_H__ + +#include + +/** + * \file energy_const.h + * energy constants + */ + +/** The gas constant */ +#define GASCONST 1.98717 /* in [cal/K] */ +/** 0 deg Celsius in Kelvin */ +#define K0 273.15 +/** Infinity as used in minimization routines */ +#define INF 10000000 /* (INT_MAX/10) */ + +#define EMAX (INF/10) +/** forbidden */ +#define FORBIDDEN 9999 +/** bonus contribution */ +#define BONUS 10000 +/** The number of distinguishable base pairs */ +#define NBPAIRS 7 +/** The minimum loop length */ +#define TURN 3 +/** The maximum loop length */ +#define MAXLOOP 30 + +#define VRNA_GQUAD_MISMATCH_PENALTY 300 /* penalty for incompatible nucleotides in an alignment that destruct a gquad layer */ +#define VRNA_GQUAD_MISMATCH_NUM_ALI 1 /* maximum number of mismatching sequences in the alignment when gquad should be formed */ + +#endif diff --git a/include/energy_par.h b/include/energy_par.h new file mode 100644 --- /dev/null +++ b/include/energy_par.h @@ -0,0 +1,100 @@ +/* + prototypes for energy_par.c +*/ + +#ifndef __VIENNA_RNA_PACKAGE_ENERGY_PAR_H__ +#define __VIENNA_RNA_PACKAGE_ENERGY_PAR_H__ + +#include "energy_const.h" + +#define PUBLIC + + +extern double lxc37; /* parameter for logarithmic loop + energy extrapolation */ + +extern int stack37[NBPAIRS+1][NBPAIRS+1]; +extern int stackdH[NBPAIRS+1][NBPAIRS+1]; /* stack enthalpies */ +extern int entropies[NBPAIRS+1][NBPAIRS+1]; /* not used anymore */ + +extern int hairpin37[31]; +extern int hairpindH[31]; +extern int bulge37[31]; +extern int bulgedH[31]; +extern int internal_loop37[31]; +extern int internal_loopdH[31]; +extern int internal2_energy; +extern int old_mismatch_37[NBPAIRS+1][5][5]; +extern int mismatchI37[NBPAIRS+1][5][5]; /* interior loop mismatches */ +extern int mismatchIdH[NBPAIRS+1][5][5]; /* interior loop mismatches */ +extern int mismatch1nI37[NBPAIRS+1][5][5]; /* interior loop mismatches */ +extern int mismatch23I37[NBPAIRS+1][5][5]; /* interior loop mismatches */ +extern int mismatch1nIdH[NBPAIRS+1][5][5]; /* interior loop mismatches */ +extern int mismatch23IdH[NBPAIRS+1][5][5]; /* interior loop mismatches */ +extern int mismatchH37[NBPAIRS+1][5][5]; /* same for hairpins */ +extern int mismatchM37[NBPAIRS+1][5][5]; /* same for multiloops */ +extern int mismatchHdH[NBPAIRS+1][5][5]; /* same for hairpins */ +extern int mismatchMdH[NBPAIRS+1][5][5]; /* same for multiloops */ +extern int mismatchExt37[NBPAIRS+1][5][5]; +extern int mismatchExtdH[NBPAIRS+1][5][5]; + +extern int dangle5_37[NBPAIRS+1][5]; /* 5' dangle exterior of pair */ +extern int dangle3_37[NBPAIRS+1][5]; /* 3' dangle */ +extern int dangle3_dH[NBPAIRS+1][5]; /* corresponding enthalpies */ +extern int dangle5_dH[NBPAIRS+1][5]; + +extern int int11_37[NBPAIRS+1][NBPAIRS+1][5][5]; /* 1x1 interior loops */ +extern int int11_dH[NBPAIRS+1][NBPAIRS+1][5][5]; + +extern int int21_37[NBPAIRS+1][NBPAIRS+1][5][5][5]; /* 2x1 interior loops */ +extern int int21_dH[NBPAIRS+1][NBPAIRS+1][5][5][5]; + +extern int int22_37[NBPAIRS+1][NBPAIRS+1][5][5][5][5]; /* 2x2 interior loops */ +extern int int22_dH[NBPAIRS+1][NBPAIRS+1][5][5][5][5]; + +/* constants for linearly destabilizing contributions for multi-loops + F = ML_closing + ML_intern*(k-1) + ML_BASE*u */ +extern int ML_BASE37; +extern int ML_BASEdH; +extern int ML_closing37; +extern int ML_closingdH; +extern int ML_intern37; +extern int ML_interndH; + +extern int TripleC37; +extern int TripleCdH; +extern int MultipleCA37; +extern int MultipleCAdH; +extern int MultipleCB37; +extern int MultipleCBdH; + +/* Ninio-correction for asymmetric internal loops with branches n1 and n2 */ +/* ninio_energy = min{max_ninio, |n1-n2|*F_ninio[min{4.0, n1, n2}] } */ +extern int MAX_NINIO; /* maximum correction */ +extern int ninio37; +extern int niniodH; +/* penalty for helices terminated by AU (actually not GC) */ +extern int TerminalAU37; +extern int TerminalAUdH; +/* penalty for forming bi-molecular duplex */ +extern int DuplexInit37; +extern int DuplexInitdH; +/* stabilizing contribution due to special hairpins of size 4 (tetraloops) */ +extern char Tetraloops[]; /* string containing the special tetraloops */ +extern int Tetraloop37[]; /* Bonus energy for special tetraloops */ +extern int TetraloopdH[]; +extern char Triloops[]; /* string containing the special triloops */ +extern int Triloop37[]; /* Bonus energy for special Triloops */ +extern int TriloopdH[]; /* Bonus energy for special Triloops */ +extern char Hexaloops[]; /* string containing the special triloops */ +extern int Hexaloop37[]; /* Bonus energy for special Triloops */ +extern int HexaloopdH[]; /* Bonus energy for special Triloops */ + +extern int GQuadAlpha37; +extern int GQuadAlphadH; +extern int GQuadBeta37; +extern int GQuadBetadH; + +extern double Tmeasure; /* temperature of param measurements */ + +#endif diff --git a/include/fold.h b/include/fold.h new file mode 100644 --- /dev/null +++ b/include/fold.h @@ -0,0 +1,604 @@ +#ifndef __VIENNA_RNA_PACKAGE_FOLD_H__ +#define __VIENNA_RNA_PACKAGE_FOLD_H__ + +#include "data_structures.h" + +#ifdef __GNUC__ +#define DEPRECATED(func) func __attribute__ ((deprecated)) +#else +#define DEPRECATED(func) func +#endif + +/** + * \addtogroup mfe_fold + * \ingroup folding_routines + * \brief This section covers all functions and variables related to the calculation + * of minimum free energy (MFE) structures. + * + * The library provides a fast dynamic programming minimum free energy + * folding algorithm as described in \cite zuker:1981. + * All relevant parts that directly implement the "Zuker & Stiegler" algorithm for single + * sequences are described in this section. + * + * Folding of circular RNA sequences is handled as a post-processing step of the forward + * recursions. See \cite hofacker:2006 for further details. + * + * Nevertheless, the RNAlib also + * provides interfaces for the prediction of consensus MFE structures of sequence alignments, + * MFE structure for two hybridized sequences, local optimal structures and many more. For + * those more specialized variants of MFE folding routines, please consult the appropriate + * subsections (Modules) as listed above. + * + * \file fold.h + * \brief MFE calculations and energy evaluations for single RNA sequences + * + * This file includes (almost) all function declarations within the RNAlib that are related to + * MFE folding... + */ + +/** + * \defgroup eval Energy evaluation + * @{ + * \brief This module contains all functions and variables related to energy evaluation + * of sequence/structure pairs. + * + * + * @} + */ + +/** + * \defgroup mfe_fold Calculating Minimum Free Energy Structures + * @{ + * \brief This module contains all functions and variables related to the calculation + * of global minimum free energy structures for single sequences. + * + * The library provides a fast dynamic programming minimum free energy + * folding algorithm as described by \ref zuker_81 "Zuker & Stiegler (1981)". + * @} + */ + +/** \brief if nonzero use logarithmic ML energy in energy_of_struct */ +extern int logML; + +/** \brief do ML decomposition uniquely (for subopt) */ +extern int uniq_ML; + +/** \brief set to first pos of second seq for cofolding */ +extern int cut_point; + +/** + * \brief verbose info from energy_of_struct + * \ingroup eval + */ +extern int eos_debug; + + +/** + * \brief Compute minimum free energy and an appropriate secondary + * structure of an RNA sequence + * + * The first parameter given, the RNA sequence, must be \a uppercase and should only contain + * an alphabet \f$\Sigma\f$ that is understood by the RNAlib\n + * (e.g. \f$ \Sigma = \{A,U,C,G\} \f$)\n + * + * The second parameter, \a structure, must always point to an allocated + * block of memory with a size of at least \f$\mathrm{strlen}(\mathrm{sequence})+1\f$ + * + * If the third parameter is NULL, global model detail settings are assumed for the folding + * recursions. Otherwise, the provided parameters are used. + * + * The fourth parameter indicates whether a secondary structure constraint in enhanced dot-bracket + * notation is passed through the structure parameter or not. If so, the characters " | x < > " are + * recognized to mark bases that are paired, unpaired, paired upstream, or downstream, respectively. + * Matching brackets " ( ) " denote base pairs, dots "." are used for unconstrained bases. + * + * To indicate that the RNA sequence is circular and thus has to be post-processed, set the last + * parameter to non-zero + * + * After a successful call of fold_par(), a backtracked secondary structure (in dot-bracket notation) + * that exhibits the minimum of free energy will be written to the memory \a structure is pointing to. + * The function returns the minimum of free energy for any fold of the sequence given. + * + * \note OpenMP: Passing NULL to the 'parameters' argument involves access to several global model + * detail variables and thus is not to be considered threadsafe + * + * \ingroup mfe_fold + * + * \see fold(), circfold(), #model_detailsT, set_energy_model(), get_scaled_parameters() + * + * \param sequence RNA sequence + * \param structure A pointer to the character array where the + * secondary structure in dot-bracket notation will be written to + * \param parameters A data structure containing the prescaled energy contributions + * and the model details. (NULL may be passed, see OpenMP notes above) + * \param is_constrained Switch to indicate that a structure contraint is passed via the structure argument (0==off) + * \param is_circular Switch to (de-)activate postprocessing steps in case RNA sequence is circular (0==off) + * + * \return the minimum free energy (MFE) in kcal/mol + */ +float fold_par( const char *sequence, + char *structure, + paramT *parameters, + int is_constrained, + int is_circular); + +/** + * \brief Compute minimum free energy and an appropriate secondary structure of an RNA sequence + * + * This function essentially does the same thing as fold_par(). However, it takes its model details, + * i.e. #temperature, #dangles, #tetra_loop, #noGU, #no_closingGU, #fold_constrained, #noLonelyPairs + * from the current global settings within the library + * + * Use fold_par() for a completely threadsafe variant + * + * \ingroup mfe_fold + * + * \see fold_par(), circfold() + * + * \param sequence RNA sequence + * \param structure A pointer to the character array where the + * secondary structure in dot-bracket notation will be written to + * \return the minimum free energy (MFE) in kcal/mol + */ +float fold( const char *sequence, + char *structure); + +/** + * \brief Compute minimum free energy and an appropriate secondary structure of a circular RNA sequence + * + * This function essentially does the same thing as fold_par(). However, it takes its model details, + * i.e. #temperature, #dangles, #tetra_loop, #noGU, #no_closingGU, #fold_constrained, #noLonelyPairs + * from the current global settings within the library + * + * Use fold_par() for a completely threadsafe variant + * + * \ingroup mfe_fold + * + * \see fold_par(), circfold() + * + * \param sequence RNA sequence + * \param structure A pointer to the character array where the + * secondary structure in dot-bracket notation will be written to + * \return the minimum free energy (MFE) in kcal/mol + */ +float circfold( const char *sequence, + char *structure); + + +/** + * \addtogroup eval Energy evaluation + * \ingroup folding_routines + * @{ + * \brief This module contains all functions and variables related to energy evaluation + * of sequence/structure pairs. + * @} + */ + +/** + * \brief Calculate the free energy of an already folded RNA using global model detail settings + * + * If verbosity level is set to a value >0, energies of structure elements are printed to stdout + * + * \note OpenMP: This function relies on several global model settings variables and thus is + * not to be considered threadsafe. See energy_of_struct_par() for a completely threadsafe + * implementation. + * + * \ingroup eval + * + * \see energy_of_struct_par(), energy_of_circ_structure() + * + * \param string RNA sequence + * \param structure secondary structure in dot-bracket notation + * \param verbosity_level a flag to turn verbose output on/off + * \return the free energy of the input structure given the input sequence in kcal/mol + */ +float energy_of_structure(const char *string, + const char *structure, + int verbosity_level); + +/** + * \brief Calculate the free energy of an already folded RNA + * + * If verbosity level is set to a value >0, energies of structure elements are printed to stdout + * + * \ingroup eval + * + * \see energy_of_circ_structure(), energy_of_structure_pt(), get_scaled_parameters() + * + * \param string RNA sequence in uppercase letters + * \param structure Secondary structure in dot-bracket notation + * \param parameters A data structure containing the prescaled energy contributions and the model details. + * \param verbosity_level A flag to turn verbose output on/off + * \return The free energy of the input structure given the input sequence in kcal/mol + */ +float energy_of_struct_par( const char *string, + const char *structure, + paramT *parameters, + int verbosity_level); + +/** + * \brief Calculate the free energy of an already folded circular RNA + * + * \note OpenMP: This function relies on several global model settings variables and thus is + * not to be considered threadsafe. See energy_of_circ_struct_par() for a completely threadsafe + * implementation. + * + * If verbosity level is set to a value >0, energies of structure elements are printed to stdout + * + * \ingroup eval + * + * \see energy_of_circ_struct_par(), energy_of_struct_par() + * + * \param string RNA sequence + * \param structure Secondary structure in dot-bracket notation + * \param verbosity_level A flag to turn verbose output on/off + * \return The free energy of the input structure given the input sequence in kcal/mol + */ +float energy_of_circ_structure( const char *string, + const char *structure, + int verbosity_level); + +/** + * \brief Calculate the free energy of an already folded circular RNA + * + * If verbosity level is set to a value >0, energies of structure elements are printed to stdout + * + * \ingroup eval + * + * \see energy_of_struct_par(), get_scaled_parameters() + * + * \param string RNA sequence + * \param structure Secondary structure in dot-bracket notation + * \param parameters A data structure containing the prescaled energy contributions and the model details. + * \param verbosity_level A flag to turn verbose output on/off + * \return The free energy of the input structure given the input sequence in kcal/mol + */ +float energy_of_circ_struct_par(const char *string, + const char *structure, + paramT *parameters, + int verbosity_level); + + +float energy_of_gquad_structure(const char *string, + const char *structure, + int verbosity_level); + +float energy_of_gquad_struct_par( const char *string, + const char *structure, + paramT *parameters, + int verbosity_level); + +/** + * \brief Calculate the free energy of an already folded RNA + * + * If verbosity level is set to a value >0, energies of structure elements are printed to stdout + * + * \note OpenMP: This function relies on several global model settings variables and thus is + * not to be considered threadsafe. See energy_of_struct_pt_par() for a completely threadsafe + * implementation. + * + * \ingroup eval + * + * \see make_pair_table(), energy_of_struct_pt_par() + * + * \param string RNA sequence + * \param ptable the pair table of the secondary structure + * \param s encoded RNA sequence + * \param s1 encoded RNA sequence + * \param verbosity_level a flag to turn verbose output on/off + * \return the free energy of the input structure given the input sequence in 10kcal/mol + */ +int energy_of_structure_pt( const char *string, + short *ptable, + short *s, + short *s1, + int verbosity_level); + +/** + * \brief Calculate the free energy of an already folded RNA + * + * If verbosity level is set to a value >0, energies of structure elements are printed to stdout + * + * \ingroup eval + * + * \see make_pair_table(), energy_of_struct_par(), get_scaled_parameters() + * + * \param string RNA sequence in uppercase letters + * \param ptable The pair table of the secondary structure + * \param s Encoded RNA sequence + * \param s1 Encoded RNA sequence + * \param parameters A data structure containing the prescaled energy contributions and the model details. + * \param verbosity_level A flag to turn verbose output on/off + * \return The free energy of the input structure given the input sequence in 10kcal/mol + */ +int energy_of_struct_pt_par(const char *string, + short *ptable, + short *s, + short *s1, + paramT *parameters, + int verbosity_level); + +/** + * \brief Free arrays for mfe folding + * + * \ingroup mfe_fold + * + */ +void free_arrays(void); + + +/** + * \brief Create a dot-backet/parenthesis structure from backtracking stack + * + * \note This function is threadsafe + */ +void parenthesis_structure(char *structure, + bondT *bp, + int length); + +/** + * \brief Create a dot-backet/parenthesis structure from backtracking stack + * obtained by zuker suboptimal calculation in cofold.c + * + * \note This function is threadsafe + */ +void parenthesis_zuker( char *structure, + bondT *bp, + int length); + +void letter_structure(char *structure, + bondT *bp, + int length); + + +/** + * \brief Recalculate energy parameters + * + * \ingroup mfe_fold + */ +void update_fold_params(void); + +/** + * + * \ingroup mfe_fold + * + */ +void update_fold_params_par(paramT *parameters); + +/** + * + * \ingroup mfe_fold + * + */ +char *backtrack_fold_from_pair(char *sequence, + int i, + int j); + +/** + * \brief Calculate energy of a move (closing or opening of a base pair) + * + * If the parameters m1 and m2 are negative, it is deletion (opening) + * of a base pair, otherwise it is insertion (opening). + * + * \see make_pair_table(), energy_of_move() + * \param string RNA sequence + * \param structure secondary structure in dot-bracket notation + * \param m1 first coordinate of base pair + * \param m2 second coordinate of base pair + * \returns energy change of the move in kcal/mol + */ +float energy_of_move( const char *string, + const char *structure, + int m1, + int m2); + + +/** + * + * \brief Calculate energy of a move (closing or opening of a base pair) + * + * If the parameters m1 and m2 are negative, it is deletion (opening) + * of a base pair, otherwise it is insertion (opening). + * + * \see make_pair_table(), energy_of_move() + * \param pt the pair table of the secondary structure + * \param s encoded RNA sequence + * \param s1 encoded RNA sequence + * \param m1 first coordinate of base pair + * \param m2 second coordinate of base pair + * \returns energy change of the move in 10cal/mol + */ +int energy_of_move_pt(short *pt, + short *s, + short *s1, + int m1, + int m2); + +/** + * \brief Calculate energy of a loop + * + * \param ptable the pair table of the secondary structure + * \param s encoded RNA sequence + * \param s1 encoded RNA sequence + * \param i position of covering base pair + * \returns free energy of the loop in 10cal/mol + */ +int loop_energy(short *ptable, + short *s, + short *s1, + int i); + +/** + * + * \ingroup mfe_fold + * + */ +void export_fold_arrays(int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p); + +/** + * + * \ingroup mfe_fold + * + */ +void export_fold_arrays_par(int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p, + paramT **P_p); + +/** + * + * \ingroup mfe_fold + * + */ +void export_circfold_arrays(int *Fc_p, + int *FcH_p, + int *FcI_p, + int *FcM_p, + int **fM2_p, + int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p); + +/** + * + * \ingroup mfe_fold + * + */ +void export_circfold_arrays_par(int *Fc_p, + int *FcH_p, + int *FcI_p, + int *FcM_p, + int **fM2_p, + int **f5_p, + int **c_p, + int **fML_p, + int **fM1_p, + int **indx_p, + char **ptype_p, + paramT **P_p); + + +/** + * \brief Create a plist from a dot-bracket string + * + * The dot-bracket string is parsed and for each base pair an + * entry in the plist is created. The probability of each pair in + * the list is set by a function parameter. + * + * The end of the plist is marked by sequence positions i as well as j + * equal to 0. This condition should be used to stop looping over its + * entries + * + * This function is threadsafe + * + * \param pl A pointer to the plist that is to be created + * \param struc The secondary structure in dot-bracket notation + * \param pr The probability for each base pair + */ +void assign_plist_from_db(plist **pl, + const char *struc, + float pr); + +/* finally moved the loop energy function declarations to this header... */ +/* BUT: The functions only exist for backward compatibility reasons! */ +/* You better include "loop_energies.h" and call the functions: */ +/* E_Hairpin() and E_IntLoop() which are (almost) threadsafe as they get */ +/* a pointer to the energy parameter datastructure as additional argument */ + +/** + * \deprecated {This function is deprecated and will be removed soon. + * Use \ref E_IntLoop() instead!} + */ +DEPRECATED(int LoopEnergy(int n1, + int n2, + int type, + int type_2, + int si1, + int sj1, + int sp1, + int sq1)); + +/** + * \deprecated {This function is deprecated and will be removed soon. + * Use \ref E_Hairpin() instead!} + */ +DEPRECATED(int HairpinE(int size, + int type, + int si1, + int sj1, + const char *string)); + +/** + * Allocate arrays for folding\n + * \deprecated {This function is deprecated and will be removed soon!} + * + */ +DEPRECATED(void initialize_fold(int length)); + +/** + * Calculate the free energy of an already folded RNA + * + * \note This function is not entirely threadsafe! Depending on the state of the global + * variable \ref eos_debug it prints energy information to stdout or not...\n + * + * \deprecated This function is deprecated and should not be used in future programs! + * Use \ref energy_of_structure() instead! + * + * \see energy_of_structure, energy_of_circ_struct(), energy_of_struct_pt() + * \param string RNA sequence + * \param structure secondary structure in dot-bracket notation + * \return the free energy of the input structure given the input sequence in kcal/mol + */ +DEPRECATED(float energy_of_struct(const char *string, + const char *structure)); + +/** + * Calculate the free energy of an already folded RNA + * + * \note This function is not entirely threadsafe! Depending on the state of the global + * variable \ref eos_debug it prints energy information to stdout or not...\n + * + * \deprecated This function is deprecated and should not be used in future programs! + * Use \ref energy_of_structure_pt() instead! + * + * \see make_pair_table(), energy_of_structure() + * \param string RNA sequence + * \param ptable the pair table of the secondary structure + * \param s encoded RNA sequence + * \param s1 encoded RNA sequence + * \return the free energy of the input structure given the input sequence in 10kcal/mol + */ +DEPRECATED(int energy_of_struct_pt( const char *string, + short *ptable, + short *s, + short *s1)); + +/** + * Calculate the free energy of an already folded circular RNA + * + * \note This function is not entirely threadsafe! Depending on the state of the global + * variable \ref eos_debug it prints energy information to stdout or not...\n + * + * \deprecated This function is deprecated and should not be used in future programs + * Use \ref energy_of_circ_structure() instead! + * + * \see energy_of_circ_structure(), energy_of_struct(), energy_of_struct_pt() + * \param string RNA sequence + * \param structure secondary structure in dot-bracket notation + * \return the free energy of the input structure given the input sequence in kcal/mol + */ +DEPRECATED(float energy_of_circ_struct( const char *string, + const char *structure)); + +#endif diff --git a/include/fold_vars.h b/include/fold_vars.h new file mode 100644 --- /dev/null +++ b/include/fold_vars.h @@ -0,0 +1,217 @@ +#ifndef __VIENNA_RNA_PACKAGE_FOLD_VARS_H__ +#define __VIENNA_RNA_PACKAGE_FOLD_VARS_H__ + +#include "data_structures.h" + +/** + * \file fold_vars.h + * \brief Here all all declarations of the global variables used throughout RNAlib + */ + + +#define PUBLIC +#define PRIVATE static + +/** + * \brief Global switch to activate/deactivate folding with structure constraints + */ +extern int fold_constrained; + +/** + * \brief Global switch to avoid/allow helices of length 1 + * + * Disallow all pairs which can only occur as lonely pairs (i.e. as helix + * of length 1). This avoids lonely base pairs in the predicted structures in + * most cases. + */ +extern int noLonelyPairs; + +/** + * \brief Switch the energy model for dangling end contributions (0, 1, 2, 3) + * + * If set to 0 no stabilizing energies are assigned to bases adjacent to + * helices in free ends and multiloops (so called dangling ends). Normally + * (dangles = 1) dangling end energies are assigned only to unpaired + * bases and a base cannot participate simultaneously in two dangling ends. In + * the partition function algorithm pf_fold() these checks are neglected. + * If #dangles is set to 2, all folding routines will follow this convention. + * This treatment of dangling ends gives more favorable energies to helices + * directly adjacent to one another, which can be beneficial since such + * helices often do engage in stabilizing interactions through co-axial + * stacking.\n + * If dangles = 3 co-axial stacking is explicitly included for + * adjacent helices in mutli-loops. The option affects only mfe folding + * and energy evaluation (fold() and energy_of_structure()), as + * well as suboptimal folding (subopt()) via re-evaluation of energies. + * Co-axial stacking with one intervening mismatch is not considered so far. + * + * Default is 2 in most algorithms, partition function algorithms can only handle 0 and 2 + */ +extern int dangles; + +/** + * \brief Global switch to forbid/allow GU base pairs at all + */ +extern int noGU; + +/** + * \brief GU allowed only inside stacks if set to 1 + */ +extern int no_closingGU; + +/** + * \brief Include special stabilizing energies for some tri-, tetra- and hexa-loops; + * + * default is 1. + */ +extern int tetra_loop; + +/** + * \brief 0 = BP; 1=any mit GC; 2=any mit AU-parameter + * + * If set to 1 or 2: fold sequences from an artificial alphabet ABCD..., where A + * pairs B, C pairs D, etc. using either GC (1) or AU parameters (2); + * default is 0, you probably don't want to change it. + */ +extern int energy_set; + +/** + * \brief backward compatibility variable.. this does not effect anything + */ +extern int circ; + +/** + * \brief generate comma seperated output + */ +extern int csv; + +/** + * use old alifold energies (with gaps) + */ +extern int oldAliEn; +/** + * use ribosum matrices + */ +extern int ribo; + +/** + * warning this variable will vanish in the future + * ribosums will be compiled in instead + */ +extern char *RibosumFile; + +/** + * \brief contains allowed non standard base pairs + * + * Lists additional base pairs that will be allowed to form in addition to + * GC, CG, AU, UA, GU and UG. Nonstandard base pairs are given a stacking + * energy of 0. + */ +extern char *nonstandards; + +/** + * \brief Rescale energy parameters to a temperature in degC. + * + * Default is 37C. You have to call the update_..._params() functions after + * changing this parameter. + */ +extern double temperature; + +/** + * interior loops of size 2 get energy 0.8Kcal and + * no mismatches, default 1 + */ +extern int james_rule; + +/** + * use logarithmic multiloop energy function + */ +extern int logML; + +/** + * \brief Marks the position (starting from 1) of the first + * nucleotide of the second molecule within the concatenated sequence. + * + * To evaluate the energy of a duplex structure (a structure formed by two + * strands), concatenate the to sequences and set it to the + * first base of the second strand in the concatenated sequence. + * The default value of -1 stands for single molecule folding. The + * cut_point variable is also used by PS_rna_plot() and + * PS_dot_plot() to mark the chain break in postscript plots. + */ +extern int cut_point; + +/** + * \brief Contains a list of base pairs after a call to fold(). + * + * base_pair[0].i contains the total number of pairs. + * \deprecated Do not use this variable anymore! + */ +extern bondT *base_pair; + +/** + * \brief A pointer to the base pair probability matrix + * + * \deprecated Do not use this variable anymore! + */ +extern FLT_OR_DBL *pr; + +/** + * \brief index array to move through pr. + * + * The probability for base i and j to form a pair is in pr[iindx[i]-j]. + * \deprecated Do not use this variable anymore! + */ +extern int *iindx; + +/** + * \brief A scaling factor used by pf_fold() to avoid overflows. + * + * Should be set to approximately \f$exp{((-F/kT)/length)}\f$, where \f$F\f$ is an estimate + * for the ensemble free energy, for example the minimum free energy. You must + * call update_pf_params() after changing this parameter.\n + * If pf_scale is -1 (the default) , an estimate will be provided + * automatically when computing partition functions, e.g. pf_fold() + * The automatic estimate is usually insufficient for sequences more + * than a few hundred bases long. + */ +extern double pf_scale; + +/** + * \brief do backtracking, i.e. compute secondary structures or base pair probabilities + * + * If 0, do not calculate pair probabilities in pf_fold(); this is about + * twice as fast. Default is 1. + */ +extern int do_backtrack; + +/** + * \brief A backtrack array marker for inverse_fold() + * + * If set to 'C': force (1,N) to be paired, + * 'M' fold as if the sequence were inside a multi-loop. Otherwise ('F') the + * usual mfe structure is computed. + */ +extern char backtrack_type; + +/** + * \brief Allow G-quadruplex formation + */ +extern int gquad; + + +char * option_string(void); + +/** + * \brief Set default model details + * + * Use this function if you wish to initialize a #model_detailsT data structure with + * its default values, i.e. the global model settings + * + * \see + * + * \param md A pointer to the data structure that shall be initialized + */ +void set_model_details(model_detailsT *md); + +#endif diff --git a/include/gquad.h b/include/gquad.h new file mode 100644 --- /dev/null +++ b/include/gquad.h @@ -0,0 +1,725 @@ +#ifndef __VIENNA_RNA_PACKAGE_GQUAD_H__ +#define __VIENNA_RNA_PACKAGE_GQUAD_H__ + +#include "data_structures.h" + +#ifndef INLINE +#ifdef __GNUC__ +# define INLINE inline +#else +# define INLINE +#endif +#endif + +/** + * \file gquad.h + * \brief Various functions related to G-quadruplex computations + */ + + +int E_gquad(int L, + int l[3], + paramT *P); + +FLT_OR_DBL exp_E_gquad( int L, + int l[3], + pf_paramT *pf); + +int E_gquad_ali(int i, + int L, + int l[3], + const short **S, + int n_seq, + paramT *P); + + +void E_gquad_ali_en( int i, + int L, + int l[3], + const short **S, + int n_seq, + int en[2], + paramT *P); + +/** + * \brief Get a triangular matrix prefilled with minimum free energy + * contributions of G-quadruplexes. + * + * At each position ij in the matrix, the minimum free energy of any + * G-quadruplex delimited by i and j is stored. If no G-quadruplex formation + * is possible, the matrix element is set to INF. + * Access the elements in the matrix via matrix[indx[j]+i]. To get + * the integer array indx see get_jindx(). + * + * \see get_jindx(), encode_sequence() + * + * \param S The encoded sequence + * \param P A pointer to the data structure containing the precomputed energy contributions + * \return A pointer to the G-quadruplex contribution matrix +*/ +int *get_gquad_matrix(short *S, paramT *P); + +int *get_gquad_ali_matrix(short *S_cons, + short **S, + int n_seq, + paramT *P); + +FLT_OR_DBL *get_gquad_pf_matrix( short *S, + FLT_OR_DBL *scale, + pf_paramT *pf); + +int **get_gquad_L_matrix( short *S, + int start, + int maxdist, + int **g, + paramT *P); + +void get_gquad_pattern_mfe(short *S, + int i, + int j, + paramT *P, + int *L, + int l[3]); + +void +get_gquad_pattern_exhaustive( short *S, + int i, + int j, + paramT *P, + int *L, + int *l, + int threshold); + +void get_gquad_pattern_pf( short *S, + int i, + int j, + pf_paramT *pf, + int *L, + int l[3]); + +plist *get_plist_gquad_from_pr( short *S, + int gi, + int gj, + FLT_OR_DBL *G, + FLT_OR_DBL *probs, + FLT_OR_DBL *scale, + pf_paramT *pf); +plist *get_plist_gquad_from_pr_max(short *S, + int gi, + int gj, + FLT_OR_DBL *G, + FLT_OR_DBL *probs, + FLT_OR_DBL *scale, + int *L, + int l[3], + pf_paramT *pf); + +plist *get_plist_gquad_from_db( const char *structure, + float pr); + +int get_gquad_count(short *S, + int i, + int j); + +int get_gquad_layer_count(short *S, + int i, + int j); + + +/** + * given a dot-bracket structure (possibly) containing gquads encoded + * by '+' signs, find first gquad, return end position or 0 if none found + * Upon return L and l[] contain the number of stacked layers, as well as + * the lengths of the linker regions. + * To parse a string with many gquads, call parse_gquad repeatedly e.g. + * end1 = parse_gquad(struc, &L, l); ... ; + * end2 = parse_gquad(struc+end1, &L, l); end2+=end1; ... ; + * end3 = parse_gquad(struc+end2, &L, l); end3+=end2; ... ; + */ +int parse_gquad(const char *struc, int *L, int l[3]); + + + +/** + * backtrack an interior loop like enclosed g-quadruplex + * with closing pair (i,j) + * + * \param c The total contribution the loop should resemble + * \param i position i of enclosing pair + * \param j position j of enclosing pair + * \param type base pair type of enclosing pair (must be reverse type) + * \param S integer encoded sequence + * \param ggg triangular matrix containing g-quadruplex contributions + * \param index the index for accessing the triangular matrix + * \param p here the 5' position of the gquad is stored + * \param q here the 3' position of the gquad is stored + * \param P the datastructure containing the precalculated contibutions + * + * \return 1 on success, 0 if no gquad found + */ +INLINE PRIVATE int backtrack_GQuad_IntLoop(int c, + int i, + int j, + int type, + short *S, + int *ggg, + int *index, + int *p, + int *q, + paramT *P){ + + int energy, dangles, k, l, maxl, minl, c0, l1; + short si, sj; + + dangles = P->model_details.dangles; + si = S[i + 1]; + sj = S[j - 1]; + energy = 0; + + if(dangles == 2) + energy += P->mismatchI[type][si][sj]; + + if(type > 2) + energy += P->TerminalAU; + + k = i + 1; + if(S[k] == 3){ + if(k < j - VRNA_GQUAD_MIN_BOX_SIZE){ + minl = j - i + k - MAXLOOP - 2; + c0 = k + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minl = MAX2(c0, minl); + c0 = j - 3; + maxl = k + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxl = MIN2(c0, maxl); + for(l = minl; l < maxl; l++){ + if(S[l] != 3) continue; + if(c == energy + ggg[index[l] + k] + P->internal_loop[j - l - 1]){ + *p = k; *q = l; + return 1; + } + } + } + } + + for(k = i + 2; + k < j - VRNA_GQUAD_MIN_BOX_SIZE; + k++){ + l1 = k - i - 1; + if(l1>MAXLOOP) break; + if(S[k] != 3) continue; + minl = j - i + k - MAXLOOP - 2; + c0 = k + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minl = MAX2(c0, minl); + c0 = j - 1; + maxl = k + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxl = MIN2(c0, maxl); + for(l = minl; l < maxl; l++){ + if(S[l] != 3) continue; + if(c == energy + ggg[index[l] + k] + P->internal_loop[l1 + j - l - 1]){ + *p = k; *q = l; + return 1; + } + } + } + + l = j - 1; + if(S[l] == 3) + for(k = i + 4; + k < j - VRNA_GQUAD_MIN_BOX_SIZE; + k++){ + l1 = k - i - 1; + if(l1>MAXLOOP) break; + if(S[k] != 3) continue; + if(c == energy + ggg[index[l] + k] + P->internal_loop[l1]){ + *p = k; *q = l; + return 1; + } + } + + return 0; +} + +/** + * backtrack an interior loop like enclosed g-quadruplex + * with closing pair (i,j) with underlying Lfold matrix + * + * \param c The total contribution the loop should resemble + * \param i position i of enclosing pair + * \param j position j of enclosing pair + * \param type base pair type of enclosing pair (must be reverse type) + * \param S integer encoded sequence + * \param ggg triangular matrix containing g-quadruplex contributions + * \param p here the 5' position of the gquad is stored + * \param q here the 3' position of the gquad is stored + * \param P the datastructure containing the precalculated contibutions + * + * \return 1 on success, 0 if no gquad found + */ +INLINE PRIVATE int backtrack_GQuad_IntLoop_L(int c, + int i, + int j, + int type, + short *S, + int **ggg, + int maxdist, + int *p, + int *q, + paramT *P){ + + int energy, dangles, k, l, maxl, minl, c0, l1; + short si, sj; + + dangles = P->model_details.dangles; + si = S[i + 1]; + sj = S[j - 1]; + energy = 0; + + if(dangles == 2) + energy += P->mismatchI[type][si][sj]; + + if(type > 2) + energy += P->TerminalAU; + + k = i + 1; + if(S[k] == 3){ + if(k < j - VRNA_GQUAD_MIN_BOX_SIZE){ + minl = j - i + k - MAXLOOP - 2; + c0 = k + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minl = MAX2(c0, minl); + c0 = j - 3; + maxl = k + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxl = MIN2(c0, maxl); + for(l = minl; l < maxl; l++){ + if(S[l] != 3) continue; + if(c == energy + ggg[k][l - k] + P->internal_loop[j - l - 1]){ + *p = k; *q = l; + return 1; + } + } + } + } + + for(k = i + 2; + k < j - VRNA_GQUAD_MIN_BOX_SIZE; + k++){ + l1 = k - i - 1; + if(l1>MAXLOOP) break; + if(S[k] != 3) continue; + minl = j - i + k - MAXLOOP - 2; + c0 = k + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minl = MAX2(c0, minl); + c0 = j - 1; + maxl = k + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxl = MIN2(c0, maxl); + for(l = minl; l < maxl; l++){ + if(S[l] != 3) continue; + if(c == energy + ggg[k][l - k] + P->internal_loop[l1 + j - l - 1]){ + *p = k; *q = l; + return 1; + } + } + } + + l = j - 1; + if(S[l] == 3) + for(k = i + 4; + k < j - VRNA_GQUAD_MIN_BOX_SIZE; + k++){ + l1 = k - i - 1; + if(l1>MAXLOOP) break; + if(S[k] != 3) continue; + if(c == energy + ggg[k][l - k] + P->internal_loop[l1]){ + *p = k; *q = l; + return 1; + } + } + + return 0; +} + +INLINE PRIVATE +int +E_GQuad_IntLoop(int i, + int j, + int type, + short *S, + int *ggg, + int *index, + paramT *P){ + + int energy, ge, en1, en2, dangles, p, q, l1, minq, maxq; + int c0, c1, c2, c3, up, d53, d5, d3; + short si, sj; + + dangles = P->model_details.dangles; + si = S[i + 1]; + sj = S[j - 1]; + energy = 0; + + if(dangles == 2) + energy += P->mismatchI[type][si][sj]; + + if(type > 2) + energy += P->TerminalAU; + + ge = INF; + + p = i + 1; + if(S[p] == 3){ + if(p < j - VRNA_GQUAD_MIN_BOX_SIZE){ + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 3; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = energy + ggg[index[q] + p] + P->internal_loop[j - q - 1]; + ge = MIN2(ge, c0); + } + } + } + + for(p = i + 2; + p < j - VRNA_GQUAD_MIN_BOX_SIZE; + p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 1; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = energy + ggg[index[q] + p] + P->internal_loop[l1 + j - q - 1]; + ge = MIN2(ge, c0); + } + } + + q = j - 1; + if(S[q] == 3) + for(p = i + 4; + p < j - VRNA_GQUAD_MIN_BOX_SIZE; + p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + c0 = energy + ggg[index[q] + p] + P->internal_loop[l1]; + ge = MIN2(ge, c0); + } + +#if 0 + /* here comes the additional stuff for the odd dangle models */ + if(dangles % 1){ + en1 = energy + P->dangle5[type][si]; + en2 = energy + P->dangle5[type][sj]; + en3 = energy + P->mismatchI[type][si][sj]; + + /* first case with 5' dangle (i.e. j-1) onto enclosing pair */ + p = i + 1; + if(S[p] == 3){ + if(p < j - VRNA_GQUAD_MIN_BOX_SIZE){ + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 4; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = en1 + ggg[index[q] + p] + P->internal_loop[j - q - 1]; + ge = MIN2(ge, c0); + } + } + } + + for(p = i + 2; p < j - VRNA_GQUAD_MIN_BOX_SIZE; p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 2; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = en1 + ggg[index[q] + p] + P->internal_loop[l1 + j - q - 1]; + ge = MIN2(ge, c0); + } + } + + q = j - 2; + if(S[q] == 3) + for(p = i + 4; p < j - VRNA_GQUAD_MIN_BOX_SIZE; p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + c0 = en1 + ggg[index[q] + p] + P->internal_loop[l1 + 1]; + ge = MIN2(ge, c0); + } + + /* second case with 3' dangle (i.e. i+1) onto enclosing pair */ + + } +#endif + return ge; +} + +INLINE PRIVATE +int * +E_GQuad_IntLoop_exhaustive( int i, + int j, + int **p_p, + int **q_p, + int type, + short *S, + int *ggg, + int threshold, + int *index, + paramT *P){ + + int energy, *ge, en1, en2, dangles, p, q, l1, minq, maxq; + int c0, c1, c2, c3, up, d53, d5, d3; + short si, sj; + int cnt = 0; + + dangles = P->model_details.dangles; + si = S[i + 1]; + sj = S[j - 1]; + energy = 0; + + if(dangles == 2) + energy += P->mismatchI[type][si][sj]; + + if(type > 2) + energy += P->TerminalAU; + + /* guess how many gquads are possible in interval [i+1,j-1] */ + *p_p = (int *)space(sizeof(int) * 256); + *q_p = (int *)space(sizeof(int) * 256); + ge = (int *)space(sizeof(int) * 256); + + p = i + 1; + if(S[p] == 3){ + if(p < j - VRNA_GQUAD_MIN_BOX_SIZE){ + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 3; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = energy + ggg[index[q] + p] + P->internal_loop[j - q - 1]; + if(c0 <= threshold){ + ge[cnt] = energy + P->internal_loop[j - q - 1]; + (*p_p)[cnt] = p; + (*q_p)[cnt++] = q; + } + } + } + } + + for(p = i + 2; + p < j - VRNA_GQUAD_MIN_BOX_SIZE; + p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 1; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = energy + ggg[index[q] + p] + P->internal_loop[l1 + j - q - 1]; + if(c0 <= threshold){ + ge[cnt] = energy + P->internal_loop[l1 + j - q - 1]; + (*p_p)[cnt] = p; + (*q_p)[cnt++] = q; + } + } + } + + q = j - 1; + if(S[q] == 3) + for(p = i + 4; + p < j - VRNA_GQUAD_MIN_BOX_SIZE; + p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + c0 = energy + ggg[index[q] + p] + P->internal_loop[l1]; + if(c0 <= threshold){ + ge[cnt] = energy + P->internal_loop[l1]; + (*p_p)[cnt] = p; + (*q_p)[cnt++] = q; + } + } + + + (*p_p)[cnt] = -1; + + return ge; +} + +INLINE PRIVATE +int +E_GQuad_IntLoop_L(int i, + int j, + int type, + short *S, + int **ggg, + int maxdist, + paramT *P){ + + int energy, ge, en1, en2, dangles, p, q, l1, minq, maxq; + int c0, c1, c2, c3, up, d53, d5, d3; + short si, sj; + + dangles = P->model_details.dangles; + si = S[i + 1]; + sj = S[j - 1]; + energy = 0; + + if(dangles == 2) + energy += P->mismatchI[type][si][sj]; + + if(type > 2) + energy += P->TerminalAU; + + ge = INF; + + p = i + 1; + if(S[p] == 3){ + if(p < j - VRNA_GQUAD_MIN_BOX_SIZE){ + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 3; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = energy + ggg[p][q-p] + P->internal_loop[j - q - 1]; + ge = MIN2(ge, c0); + } + } + } + + for(p = i + 2; + p < j - VRNA_GQUAD_MIN_BOX_SIZE; + p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + minq = j - i + p - MAXLOOP - 2; + c0 = p + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minq = MAX2(c0, minq); + c0 = j - 1; + maxq = p + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxq = MIN2(c0, maxq); + for(q = minq; q < maxq; q++){ + if(S[q] != 3) continue; + c0 = energy + ggg[p][q - p] + P->internal_loop[l1 + j - q - 1]; + ge = MIN2(ge, c0); + } + } + + q = j - 1; + if(S[q] == 3) + for(p = i + 4; + p < j - VRNA_GQUAD_MIN_BOX_SIZE; + p++){ + l1 = p - i - 1; + if(l1>MAXLOOP) break; + if(S[p] != 3) continue; + c0 = energy + ggg[p][q - p] + P->internal_loop[l1]; + ge = MIN2(ge, c0); + } + + return ge; +} + +INLINE PRIVATE +FLT_OR_DBL +exp_E_GQuad_IntLoop(int i, + int j, + int type, + short *S, + FLT_OR_DBL *G, + int *index, + pf_paramT *pf){ + + int k, l, minl, maxl, u, r; + FLT_OR_DBL q, qe, *expintern; + short si, sj; + + q = 0; + si = S[i + 1]; + sj = S[j - 1]; + qe = pf->expmismatchI[type][si][sj]; + expintern = pf->expinternal; + + if(type > 2) + qe *= pf->expTermAU; + + k = i + 1; + if(S[k] == 3){ + if(k < j - VRNA_GQUAD_MIN_BOX_SIZE){ + minl = j - i + k - MAXLOOP - 2; + u = k + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minl = MAX2(u, minl); + u = j - 3; + maxl = k + VRNA_GQUAD_MAX_BOX_SIZE + 1; + maxl = MIN2(u, maxl); + for(l = minl; l < maxl; l++){ + if(S[l] != 3) continue; + if(G[index[k]-l] == 0.) continue; + q += qe * G[index[k]-l] * expintern[j - l - 1]; + } + } + } + + + for(k = i + 2; + k <= j - VRNA_GQUAD_MIN_BOX_SIZE; + k++){ + u = k - i - 1; + if(u > MAXLOOP) break; + if(S[k] != 3) continue; + minl = j - i + k - MAXLOOP - 2; + r = k + VRNA_GQUAD_MIN_BOX_SIZE - 1; + minl = MAX2(r, minl); + maxl = k + VRNA_GQUAD_MAX_BOX_SIZE + 1; + r = j - 1; + maxl = MIN2(r, maxl); + for(l = minl; l < maxl; l++){ + if(S[l] != 3) continue; + if(G[index[k]-l] == 0.) continue; + q += qe * G[index[k]-l] * expintern[u + j - l - 1]; + } + } + + l = j - 1; + if(S[l] == 3) + for(k = i + 4; k < j - VRNA_GQUAD_MIN_BOX_SIZE; k++){ + u = k - i - 1; + if(u>MAXLOOP) break; + if(S[k] != 3) continue; + if(G[index[k]-l] == 0.) continue; + q += qe * G[index[k]-l] * expintern[u]; + } + + return q; +} + +#endif diff --git a/include/intl11.h b/include/intl11.h new file mode 100644 --- /dev/null +++ b/include/intl11.h @@ -0,0 +1,393 @@ +PUBLIC int int11_37[NBPAIRS+1][NBPAIRS+1][5][5] = +{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ 90, 90, 50, 50, 50} + ,{ 90, 90, 50, 50, 50} + ,{ 50, 50, 50, 50, 50} + ,{ 50, 50, 50, -140, 50} + ,{ 50, 50, 50, 50, 40} + } + ,{{ 90, 90, 50, 50, 60} + ,{ 90, 90, -40, 50, 50} + ,{ 60, 30, 50, 50, 60} + ,{ 50, -10, 50, -220, 50} + ,{ 50, 50, 0, 50, -10} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 60, 50, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, -20, 120, -140, 120} + ,{ 120, 120, 100, 120, 110} + } + ,{{ 220, 220, 170, 120, 120} + ,{ 220, 220, 130, 120, 120} + ,{ 170, 120, 170, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 110} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 80} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 120} + } + ,{{ 220, 220, 170, 120, 120} + ,{ 220, 220, 130, 120, 120} + ,{ 170, 120, 170, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 120} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ 90, 90, 60, 50, 50} + ,{ 90, 90, 30, -10, 50} + ,{ 50, -40, 50, 50, 0} + ,{ 50, 50, 50, -220, 50} + ,{ 60, 50, 60, 50, -10} + } + ,{{ 80, 80, 50, 50, 50} + ,{ 80, 80, 50, 50, 50} + ,{ 50, 50, 50, 50, 50} + ,{ 50, 50, 50, -230, 50} + ,{ 50, 50, 50, 50, -60} + } + ,{{ 190, 190, 120, 150, 150} + ,{ 190, 190, 120, 150, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 150, 120, 120, 120, 150} + } + ,{{ 160, 160, 120, 120, 120} + ,{ 160, 160, 120, 100, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 70} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 80} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 120} + } + ,{{ 190, 190, 120, 150, 150} + ,{ 190, 190, 120, 150, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 150, 120, 120, 120, 150} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 60, 120, -20, 120} + ,{ 120, 50, 120, 120, 100} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 110} + } + ,{{ 190, 190, 120, 120, 150} + ,{ 190, 190, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 150, 150, 120, -140, 120} + ,{ 150, 120, 120, 120, 150} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 120} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 120} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ 220, 220, 170, 120, 120} + ,{ 220, 220, 120, 120, 120} + ,{ 170, 130, 170, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 110} + } + ,{{ 160, 160, 120, 120, 120} + ,{ 160, 160, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 100, 120, -140, 120} + ,{ 120, 120, 120, 120, 70} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 220, 220, 190, 190, 190} + ,{ 220, 220, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 80} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 80} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 120} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 120} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 150} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 120} + } + ,{{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 120} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 150} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 170} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ 220, 220, 170, 120, 120} + ,{ 220, 220, 120, 120, 120} + ,{ 170, 130, 170, 120, 120} + ,{ 120, 120, 120, -140, 120} + ,{ 120, 120, 120, 120, 120} + } + ,{{ 190, 190, 120, 120, 150} + ,{ 190, 190, 120, 120, 120} + ,{ 120, 120, 120, 120, 120} + ,{ 150, 150, 120, -140, 120} + ,{ 150, 120, 120, 120, 150} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 220, 220, 190, 190, 190} + ,{ 220, 220, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 160} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 220, 220, 190, 190, 190} + ,{ 220, 220, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, -70, 190} + ,{ 190, 190, 190, 190, 190} + } + }}; diff --git a/include/intl11dH.h b/include/intl11dH.h new file mode 100644 --- /dev/null +++ b/include/intl11dH.h @@ -0,0 +1,393 @@ +PUBLIC int int11_dH[NBPAIRS+1][NBPAIRS+1][5][5] = +{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1840, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + } + ,{{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1840, -1050} + ,{ -1050, -1050, -1050, -1050, -1390} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -550} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -550} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -550} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1840, -1050} + ,{ -1050, -1050, -1050, -1050, -1390} + } + ,{{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1050, -1050} + ,{ -1050, -1050, -1050, -1840, -1050} + ,{ -1050, -1050, -1050, -1050, -1730} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -1230} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -1230} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -1230} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -730} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -730} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -550} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -1230} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -730} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -730} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -550} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + } +,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -550} + } + ,{{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -550, -550} + ,{ -550, -550, -550, -1340, -550} + ,{ -550, -550, -550, -550, -890} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -390} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -830, -50} + ,{ -50, -50, -50, -50, -50} + } + }}; diff --git a/include/intl21.h b/include/intl21.h new file mode 100644 --- /dev/null +++ b/include/intl21.h @@ -0,0 +1,1993 @@ +PUBLIC int int21_37[NBPAIRS+1][NBPAIRS+1][5][5][5] = +{{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } +,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 230, 230, 230, 110, 230} + ,{ 230, 230, 230, 110, 230} + ,{ 230, 230, 230, 110, 230} + ,{ 110, 110, 110, 110, 110} + ,{ 230, 230, 230, 110, 230} + } + ,{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 230, 110, 230, 110, 230} + ,{ 110, 110, 110, 110, 110} + ,{ 230, 110, 230, 110, 230} + ,{ 110, 110, 110, 110, 110} + ,{ 230, 110, 230, 110, 230} + } + ,{{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 150, 150, 150, 150, 150} + } + } + ,{{{ 250, 250, 250, 230, 230} + ,{ 250, 250, 230, 230, 230} + ,{ 250, 230, 250, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 250, 250, 230, 230, 230} + } + ,{{ 250, 250, 230, 110, 230} + ,{ 250, 250, 230, 110, 230} + ,{ 230, 230, 170, 110, 230} + ,{ 110, 80, 110, 110, 110} + ,{ 230, 230, 230, 110, 230} + } + ,{{ 250, 250, 250, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 250, 230, 250, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 250, 250, 230, 230, 230} + } + ,{{ 230, 170, 230, 110, 230} + ,{ 230, 170, 230, 80, 230} + ,{ 230, 110, 230, 110, 230} + ,{ 120, 120, 110, 110, 110} + ,{ 230, 110, 230, 110, 230} + } + ,{{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 230, 230, 220, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 170, 150, 170, 150, 140} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + } +,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 250, 250, 230, 230, 230} + ,{ 250, 250, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 250, 250, 230, 230, 230} + ,{ 250, 250, 230, 210, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 120, 120, 110, 110, 110} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 190, 230, 230} + } + ,{{ 230, 110, 230, 110, 230} + ,{ 110, 110, 110, 110, 110} + ,{ 230, 110, 230, 110, 230} + ,{ 110, 110, 110, 110, 110} + ,{ 230, 110, 230, 110, 230} + } + ,{{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 150, 150, 150, 150, 150} + } + } + ,{{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 110, 110, 110, 110, 110} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 230, 110, 230, 110, 230} + ,{ 230, 110, 230, 110, 230} + ,{ 230, 110, 230, 110, 230} + ,{ 110, 110, 110, 110, 110} + ,{ 230, 110, 230, 110, 230} + } + ,{{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 230, 230, 230, 230, 150} + ,{ 150, 150, 150, 150, 150} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 250, 300, 210, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 120, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 190, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + } +,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 250, 300, 210, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 120, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 190, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 250, 370, 210, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 120, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 190, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + } +,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 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370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + } +,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 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370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} 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INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 300, 300, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 370, 370, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + } +,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + ,{ 300, 300, 300, 300, 300} + } + ,{{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 300, 190, 300, 190, 300} + ,{ 190, 190, 190, 190, 190} + ,{ 300, 190, 300, 190, 300} + } + ,{{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 300, 300, 300, 300, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + } + ,{{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 370, 260, 370, 260, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 370, 260, 370, 260, 370} + } + ,{{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 370, 370, 370, 370, 300} + ,{ 300, 300, 300, 300, 300} + } + } + }}; diff --git a/include/intl21dH.h b/include/intl21dH.h new file mode 100644 --- /dev/null +++ b/include/intl21dH.h @@ -0,0 +1,1993 @@ +PUBLIC int int21_dH[NBPAIRS+1][NBPAIRS+1][5][5][5] = +{{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, 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1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 780, 1350} + ,{ 1350, 1350, 1350, 780, 1350} + ,{ 1350, 1350, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 1350, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 780, 1350} + ,{ 1350, 1350, 1350, 780, 1350} + ,{ 1350, 1350, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 1350, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + } +,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + } + ,{{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 280, 280, 280, 280, 280} + ,{ 850, 850, 850, 850, 850} + } + ,{{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + } + ,{{ 850, 280, 850, 280, 850} + ,{ 280, 280, 280, 280, 280} + ,{ 850, 280, 850, 280, 850} + ,{ 280, 280, 280, 280, 280} + ,{ 850, 280, 850, 280, 850} + } + ,{{ 850, 850, 850, 850, -160} + ,{ 850, 850, 850, 850, -160} + ,{ 850, 850, 850, 850, -160} + ,{ 850, 850, 850, 850, -160} + ,{ -160, -160, -160, -160, -160} + } + } + ,{{{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + } + ,{{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 280, 280, 280, 280, 280} + ,{ 850, 850, 850, 850, 850} + } + ,{{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + ,{ 850, 850, 850, 850, 850} + } + ,{{ 850, 280, 850, 280, 850} + ,{ 850, 280, 850, 280, 850} + ,{ 850, 280, 850, 280, 850} + ,{ 280, 280, 280, 280, 280} + ,{ 850, 280, 850, 280, 850} + } + ,{{ 850, 850, 850, 850, -160} + ,{ 850, 850, 850, 850, -160} + ,{ 850, 850, 850, 850, -160} + ,{ 850, 850, 850, 850, -160} + ,{ -160, -160, -160, -160, -160} + } + } + ,{{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + ,{ 1350, 1350, 1350, 1350, 1350} + } + ,{{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 1350, 780, 1350, 780, 1350} + ,{ 780, 780, 780, 780, 780} + ,{ 1350, 780, 1350, 780, 1350} + } + ,{{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 1350, 1350, 1350, 1350, 340} + ,{ 340, 340, 340, 340, 340} + } + } + }}; diff --git a/include/intl22.h b/include/intl22.h new file mode 100644 --- /dev/null +++ b/include/intl22.h @@ -0,0 +1,9993 @@ +PUBLIC int int22_37[NBPAIRS+1][NBPAIRS+1][5][5][5][5] = +{{{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, 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170} + ,{ 220, 130, 220, 130, 170} + ,{ 150, 110, 150, 110, 150} + ,{ 140, 100, 140, 100, 140} + ,{ 170, 150, 150, 140, 170} + } + ,{{ 220, 130, 220, 130, 170} + ,{ 220, 130, 220, 130, 170} + ,{ 150, 110, 150, 100, 150} + ,{ 70, -30, 70, -70, 50} + ,{ 150, 110, 150, 100, 150} + } + ,{{ 190, 110, 190, 100, 170} + ,{ 190, 110, 190, 100, 140} + ,{ 150, 110, 150, 100, 150} + ,{ 140, 100, 140, 100, 140} + ,{ 170, 110, 150, 100, 170} + } + ,{{ 150, 110, 150, 100, 150} + ,{ 140, 70, 70, -10, 140} + ,{ 150, 110, 150, 100, 150} + ,{ 80, -30, 10, 80, 70} + ,{ 150, 110, 150, 100, 150} + } + ,{{ 150, 150, 150, 140, 150} + ,{ 140, 100, 140, 100, 140} + ,{ 150, 110, 150, 110, 150} + ,{ 140, 100, 140, 100, 140} + ,{ 150, 150, 70, 140, 70} + } + } + ,{{{ 170, 150, 150, 90, 170} + ,{ 170, 130, 140, 10, 170} + ,{ 150, 110, 150, 80, 150} + ,{ 140, 100, 140, 10, 140} + ,{ 150, 150, 150, 90, 150} + } + ,{{ 170, 130, 150, 10, 170} + ,{ 170, 130, 60, 0, 170} + ,{ 150, 110, 150, -70, 150} + ,{ 10, -30, 10, 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-10, 60} + ,{ 130, 100, 130, 100, 120} + ,{ 20, -40, -10, -40, 20} + ,{ 130, 100, 130, 100, 120} + } + ,{{ 140, 110, 140, 110, 120} + ,{ 130, 100, 130, 100, 110} + ,{ 140, 110, 140, 110, 120} + ,{ 130, 100, 130, 100, 110} + ,{ 30, -20, -10, 30, 20} + } + } + ,{{{ 170, 90, 170, 140, 170} + ,{ 170, 70, 170, -10, 170} + ,{ 150, 80, 150, -40, 150} + ,{ 140, 10, 140, 80, 140} + ,{ 150, 90, 150, 140, 150} + } + ,{{ 170, 10, 170, -10, 170} + ,{ 170, -20, 170, -10, 170} + ,{ 150, -40, 150, -40, 150} + ,{ -30, -170, -30, -90, -30} + ,{ 150, 10, 150, -40, 150} + } + ,{{ 150, 70, 150, 20, 150} + ,{ 140, 70, 140, -50, 140} + ,{ 150, 70, 150, -40, 150} + ,{ 140, 10, 140, -50, 140} + ,{ 150, 70, 150, 20, 150} + } + ,{{ 150, 10, 150, 80, 150} + ,{ 30, -50, 30, -30, 30} + ,{ 150, 10, 150, -40, 150} + ,{ 80, -30, 10, 80, 10} + ,{ 150, 10, 150, -40, 150} + } + ,{{ 150, 90, 150, 140, 150} + ,{ 140, 10, 140, -50, 140} + ,{ 150, 80, 150, -50, 150} + ,{ 140, 10, 140, -50, 140} + ,{ 140, 90, 70, 140, 70} + } + } + ,{{{ 140, 130, 140, 130, 140} + ,{ 140, 130, 140, 130, 140} + ,{ 120, 110, 120, 110, 30} + ,{ 110, 100, 110, 100, 70} + ,{ 120, 100, 120, 100, 30} + } + ,{{ 140, 130, 140, 130, 140} + ,{ 140, 130, 140, 130, 140} + ,{ 120, 100, 120, 100, 30} + ,{ 50, -70, 0, -70, 50} + ,{ 120, 100, 120, 100, 30} + } + ,{{ 120, 100, 120, 100, 30} + ,{ 110, 100, 110, 100, 30} + ,{ 120, 100, 120, 100, 30} + ,{ 110, 100, 110, 100, 20} + ,{ 120, 100, 120, 100, 30} + } + ,{{ 140, 100, 120, 100, 140} + ,{ 140, -10, 50, -10, 140} + ,{ 120, 100, 120, 100, 30} + ,{ 70, -40, -60, -40, 70} + ,{ 120, 100, 120, 100, 30} + } + ,{{ 120, 110, 120, 110, 30} + ,{ 110, 100, 110, 100, 20} + ,{ 120, 110, 120, 110, 30} + ,{ 110, 100, 110, 100, 20} + ,{ 40, 30, 40, 30, -60} + } + } + } + ,{{{{ 300, 290, 300, 260, 300} + ,{ 300, 270, 300, 260, 300} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 290, 290, 270, 220, 270} + } + ,{{ 300, 270, 300, 260, 300} + ,{ 300, 270, 300, 260, 300} + ,{ 270, 230, 270, 220, 270} + ,{ 230, 150, 230, 140, 220} + ,{ 270, 230, 270, 220, 270} + } + ,{{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + } + ,{{ 270, 230, 270, 220, 270} + ,{ 270, 190, 270, 180, 260} + ,{ 270, 230, 270, 220, 270} + ,{ 210, 130, 140, 210, 150} + ,{ 270, 230, 270, 220, 270} + } + ,{{ 290, 290, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 290, 290, 270, 220, 270} + } + } + ,{{{ 300, 290, 300, 190, 300} + ,{ 300, 270, 300, 170, 300} + ,{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 290, 290, 270, 190, 270} + } + ,{{ 300, 270, 300, 170, 300} + ,{ 300, 270, 300, 170, 300} + ,{ 270, 230, 270, 130, 270} + ,{ 190, 150, 190, 50, 190} + ,{ 270, 230, 270, 130, 270} + } + ,{{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 190, 270} + } + ,{{ 270, 230, 270, 130, 270} + ,{ 230, 190, 230, 90, 230} + ,{ 270, 230, 270, 130, 270} + ,{ 140, 100, 140, 130, 140} + ,{ 270, 230, 270, 130, 270} + } + ,{{ 290, 290, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 290, 290, 270, 130, 270} + } + } + ,{{{ 290, 260, 290, 260, 270} + ,{ 290, 260, 290, 260, 270} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + } + ,{{ 290, 260, 290, 260, 270} + ,{ 290, 260, 290, 260, 270} + ,{ 250, 220, 250, 220, 240} + ,{ 230, 140, 230, 140, 220} + ,{ 250, 220, 250, 220, 240} + } + ,{{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + } + ,{{ 270, 220, 270, 220, 260} + ,{ 270, 180, 270, 180, 260} + ,{ 250, 220, 250, 220, 240} + ,{ 120, 90, 120, 90, 110} + ,{ 250, 220, 250, 220, 240} + } + ,{{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + } + } + ,{{{ 300, 190, 300, 210, 300} + ,{ 300, 170, 300, 170, 300} + ,{ 270, 190, 270, 80, 270} + ,{ 270, 130, 270, 210, 270} + ,{ 270, 190, 270, 210, 270} + } + ,{{ 300, 170, 300, 130, 300} + ,{ 300, 170, 300, 110, 300} + ,{ 270, 130, 270, 80, 270} + ,{ 190, 50, 190, 130, 190} + ,{ 270, 130, 270, 80, 270} + } + ,{{ 270, 190, 270, 80, 270} + ,{ 270, 130, 270, 80, 270} + ,{ 270, 190, 270, 80, 270} + ,{ 270, 130, 270, 80, 270} + ,{ 270, 190, 270, 80, 270} + } + ,{{ 270, 130, 270, 210, 270} + ,{ 230, 90, 230, 170, 230} + ,{ 270, 130, 270, 80, 270} + ,{ 210, 130, 140, 210, 140} + ,{ 270, 130, 270, 80, 270} + } + ,{{ 270, 190, 270, 210, 270} + ,{ 270, 130, 270, 80, 270} + ,{ 270, 190, 270, 80, 270} + ,{ 270, 130, 270, 80, 270} + ,{ 270, 130, 270, 210, 270} + } + } + ,{{{ 270, 260, 270, 260, 240} + ,{ 270, 260, 270, 260, 240} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + } + ,{{ 270, 260, 270, 260, 240} + ,{ 270, 260, 270, 260, 240} + ,{ 240, 220, 240, 220, 150} + ,{ 220, 140, 220, 140, 70} + ,{ 240, 220, 240, 220, 150} + } + ,{{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + } + ,{{ 260, 220, 260, 220, 150} + ,{ 260, 180, 260, 180, 110} + ,{ 240, 220, 240, 220, 150} + ,{ 150, 90, 110, 90, 150} + ,{ 240, 220, 240, 220, 150} + } + ,{{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + ,{ 240, 220, 240, 220, 150} + } + } + } + ,{{{{ 310, 260, 310, 220, 300} + ,{ 310, 230, 310, 220, 300} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 260, 260, 240, 190, 240} + } + ,{{ 240, 200, 240, 190, 240} + ,{ 200, 160, 200, 160, 200} + ,{ 240, 200, 240, 190, 240} + ,{ 150, 60, 150, 60, 130} + ,{ 240, 200, 240, 190, 240} + } + ,{{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + } + ,{{ 310, 230, 310, 220, 300} + ,{ 310, 230, 310, 220, 300} + ,{ 240, 200, 240, 190, 240} + ,{ 180, 100, 110, 180, 120} + ,{ 240, 200, 240, 190, 240} + } + ,{{ 260, 260, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 260, 260, 240, 190, 240} + } + } + ,{{{ 270, 260, 270, 160, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 260, 260, 240, 160, 240} + } + ,{{ 240, 200, 240, 100, 240} + ,{ 200, 160, 200, 70, 200} + ,{ 240, 200, 240, 100, 240} + ,{ 100, 60, 100, -30, 100} + ,{ 240, 200, 240, 100, 240} + } + ,{{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 160, 240} + } + ,{{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 240, 200, 240, 100, 240} + ,{ 110, 70, 110, 100, 110} + ,{ 240, 200, 240, 100, 240} + } + ,{{ 260, 260, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 260, 260, 240, 100, 240} + } + } + ,{{{ 310, 220, 310, 220, 300} + ,{ 310, 220, 310, 220, 300} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + } + ,{{ 220, 190, 220, 190, 210} + ,{ 190, 160, 190, 160, 170} + ,{ 220, 190, 220, 190, 210} + ,{ 150, 60, 150, 60, 130} + ,{ 220, 190, 220, 190, 210} + } + ,{{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + } + ,{{ 310, 220, 310, 220, 300} + ,{ 310, 220, 310, 220, 300} + ,{ 220, 190, 220, 190, 210} + ,{ 90, 60, 90, 60, 80} + ,{ 220, 190, 220, 190, 210} + } + ,{{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + } + } + ,{{{ 270, 160, 270, 210, 270} + ,{ 270, 130, 270, 210, 270} + ,{ 240, 160, 240, 50, 240} + ,{ 240, 100, 240, 180, 240} + ,{ 240, 160, 240, 180, 240} + } + ,{{ 240, 100, 240, 50, 240} + ,{ 200, 70, 200, 10, 200} + ,{ 240, 100, 240, 50, 240} + ,{ 100, -30, 100, 40, 100} + ,{ 240, 100, 240, 50, 240} + } + ,{{ 240, 160, 240, 50, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 240, 160, 240, 50, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 240, 160, 240, 50, 240} + } + ,{{ 270, 130, 270, 210, 270} + ,{ 270, 130, 270, 210, 270} + ,{ 240, 100, 240, 50, 240} + ,{ 180, 100, 110, 180, 110} + ,{ 240, 100, 240, 50, 240} + } + ,{{ 240, 160, 240, 180, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 240, 160, 240, 50, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 240, 100, 240, 180, 240} + } + } + ,{{{ 300, 220, 300, 220, 150} + ,{ 300, 220, 300, 220, 150} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + } + ,{{ 210, 190, 210, 190, 140} + ,{ 170, 160, 170, 160, 140} + ,{ 210, 190, 210, 190, 120} + ,{ 130, 60, 130, 60, -10} + ,{ 210, 190, 210, 190, 120} + } + ,{{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + } + ,{{ 300, 220, 300, 220, 150} + ,{ 300, 220, 300, 220, 150} + ,{ 210, 190, 210, 190, 120} + ,{ 120, 60, 80, 60, 120} + ,{ 210, 190, 210, 190, 120} + } + ,{{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + } + } + } + ,{{{{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 220, 180, 220, 170, 220} + ,{ 220, 180, 220, 180, 220} + ,{ 220, 180, 220, 170, 220} + } + ,{{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 210, 170, 210, 170, 210} + ,{ 160, 70, 160, 70, 140} + ,{ 210, 170, 210, 170, 210} + } + ,{{ 220, 180, 220, 180, 220} + ,{ 220, 180, 220, 180, 220} + ,{ 220, 180, 220, 170, 220} + ,{ 220, 180, 220, 180, 220} + ,{ 220, 180, 220, 170, 220} + } + ,{{ 230, 170, 230, 170, 210} + ,{ 230, 140, 230, 140, 210} + ,{ 210, 170, 210, 170, 210} + ,{ 130, 60, 60, 130, 70} + ,{ 210, 170, 210, 170, 210} + } + ,{{ 220, 180, 220, 180, 220} + ,{ 220, 180, 220, 180, 220} + ,{ 220, 180, 220, 170, 220} + ,{ 220, 180, 220, 180, 220} + ,{ 150, 150, 130, 80, 130} + } + } + ,{{{ 240, 200, 240, 140, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 220, 180, 220, 140, 220} + ,{ 220, 180, 220, 90, 220} + ,{ 220, 180, 220, 140, 220} + } + ,{{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 210, 170, 210, 80, 210} + ,{ 110, 70, 110, -20, 110} + ,{ 210, 170, 210, 80, 210} + } + ,{{ 220, 180, 220, 140, 220} + ,{ 220, 180, 220, 90, 220} + ,{ 220, 180, 220, 140, 220} + ,{ 220, 180, 220, 90, 220} + ,{ 220, 180, 220, 140, 220} + } + ,{{ 210, 170, 210, 80, 210} + ,{ 180, 140, 180, 50, 180} + ,{ 210, 170, 210, 80, 210} + ,{ 60, 20, 60, 60, 60} + ,{ 210, 170, 210, 80, 210} + } + ,{{ 220, 180, 220, 140, 220} + ,{ 220, 180, 220, 90, 220} + ,{ 220, 180, 220, 140, 220} + ,{ 220, 180, 220, 90, 220} + ,{ 150, 150, 130, 0, 130} + } + } + ,{{{ 230, 190, 230, 190, 210} + ,{ 230, 190, 230, 190, 210} + ,{ 200, 170, 200, 170, 190} + ,{ 210, 180, 210, 180, 190} + ,{ 200, 170, 200, 170, 190} + } + ,{{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 200, 170, 200, 170, 180} + ,{ 160, 70, 160, 70, 140} + ,{ 200, 170, 200, 170, 180} + } + ,{{ 210, 180, 210, 180, 190} + ,{ 210, 180, 210, 180, 190} + ,{ 200, 170, 200, 170, 190} + ,{ 210, 180, 210, 180, 190} + ,{ 200, 170, 200, 170, 190} + } + ,{{ 230, 170, 230, 170, 210} + ,{ 230, 140, 230, 140, 210} + ,{ 200, 170, 200, 170, 180} + ,{ 50, 20, 50, 20, 30} + ,{ 200, 170, 200, 170, 180} + } + ,{{ 210, 180, 210, 180, 190} + ,{ 210, 180, 210, 180, 190} + ,{ 200, 170, 200, 170, 190} + ,{ 210, 180, 210, 180, 190} + ,{ 110, 80, 110, 80, 100} + } + } + ,{{{ 240, 140, 240, 130, 240} + ,{ 240, 100, 240, 120, 240} + ,{ 220, 140, 220, 30, 220} + ,{ 220, 90, 220, 130, 220} + ,{ 220, 140, 220, 70, 220} + } + ,{{ 240, 100, 240, 50, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 210, 80, 210, 20, 210} + ,{ 110, -20, 110, 50, 110} + ,{ 210, 80, 210, 20, 210} + } + ,{{ 220, 140, 220, 30, 220} + ,{ 220, 90, 220, 30, 220} + ,{ 220, 140, 220, 30, 220} + ,{ 220, 90, 220, 30, 220} + ,{ 220, 140, 220, 30, 220} + } + ,{{ 210, 80, 210, 130, 210} + ,{ 180, 50, 180, 120, 180} + ,{ 210, 80, 210, 20, 210} + ,{ 130, 60, 60, 130, 60} + ,{ 210, 80, 210, 20, 210} + } + ,{{ 220, 140, 220, 70, 220} + ,{ 220, 90, 220, 30, 220} + ,{ 220, 140, 220, 30, 220} + ,{ 220, 90, 220, 30, 220} + ,{ 130, 0, 130, 70, 130} + } + } + ,{{{ 210, 190, 210, 190, 180} + ,{ 210, 190, 210, 190, 180} + ,{ 190, 170, 190, 170, 100} + ,{ 190, 180, 190, 180, 100} + ,{ 190, 170, 190, 170, 100} + } + ,{{ 210, 190, 210, 190, 180} + ,{ 210, 190, 210, 190, 180} + ,{ 180, 170, 180, 170, 90} + ,{ 140, 70, 140, 70, 0} + ,{ 180, 170, 180, 170, 90} + } + ,{{ 190, 180, 190, 180, 100} + ,{ 190, 180, 190, 180, 100} + ,{ 190, 170, 190, 170, 100} + ,{ 190, 180, 190, 180, 100} + ,{ 190, 170, 190, 170, 100} + } + ,{{ 210, 170, 210, 170, 90} + ,{ 210, 140, 210, 140, 60} + ,{ 180, 170, 180, 170, 90} + ,{ 70, 20, 30, 20, 70} + ,{ 180, 170, 180, 170, 90} + } + ,{{ 190, 180, 190, 180, 100} + ,{ 190, 180, 190, 180, 100} + ,{ 190, 170, 190, 170, 100} + ,{ 190, 180, 190, 180, 100} + ,{ 100, 80, 100, 80, 10} + } + } + } + ,{{{{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + } + ,{{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 190, 150, 190, 150, 190} + ,{ 180, 90, 180, 90, 160} + ,{ 190, 150, 190, 150, 190} + } + ,{{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + } + ,{{ 190, 150, 190, 150, 190} + ,{ 190, 100, 190, 100, 170} + ,{ 190, 150, 190, 150, 190} + ,{ 150, 80, 80, 150, 90} + ,{ 190, 150, 190, 150, 190} + } + ,{{ 240, 200, 240, 190, 240} + ,{ 240, 200, 240, 190, 240} + ,{ 210, 170, 210, 160, 210} + ,{ 240, 200, 240, 190, 240} + ,{ 170, 170, 150, 110, 150} + } + } + ,{{{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 160, 240} + } + ,{{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 190, 150, 190, 60, 190} + ,{ 130, 90, 130, 0, 130} + ,{ 190, 150, 190, 60, 190} + } + ,{{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 160, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 240, 200, 240, 160, 240} + } + ,{{ 190, 150, 190, 80, 190} + ,{ 140, 100, 140, 10, 140} + ,{ 190, 150, 190, 60, 190} + ,{ 80, 40, 80, 80, 80} + ,{ 190, 150, 190, 60, 190} + } + ,{{ 240, 200, 240, 130, 240} + ,{ 240, 200, 240, 100, 240} + ,{ 210, 170, 210, 130, 210} + ,{ 240, 200, 240, 100, 240} + ,{ 170, 170, 150, 20, 150} + } + } + ,{{{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + } + ,{{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 180, 150, 180, 150, 160} + ,{ 180, 90, 180, 90, 160} + ,{ 180, 150, 180, 150, 160} + } + ,{{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + } + ,{{ 190, 150, 190, 150, 170} + ,{ 190, 100, 190, 100, 170} + ,{ 180, 150, 180, 150, 160} + ,{ 70, 40, 70, 40, 50} + ,{ 180, 150, 180, 150, 160} + } + ,{{ 220, 190, 220, 190, 210} + ,{ 220, 190, 220, 190, 210} + ,{ 190, 160, 190, 160, 180} + ,{ 220, 190, 220, 190, 210} + ,{ 140, 110, 140, 110, 120} + } + } + ,{{{ 240, 160, 240, 150, 240} + ,{ 240, 100, 240, 80, 240} + ,{ 240, 160, 240, 50, 240} + ,{ 240, 100, 240, 150, 240} + ,{ 240, 160, 240, 90, 240} + } + ,{{ 240, 100, 240, 70, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 190, 60, 190, 0, 190} + ,{ 130, 0, 130, 70, 130} + ,{ 190, 60, 190, 0, 190} + } + ,{{ 240, 160, 240, 50, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 240, 160, 240, 50, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 240, 160, 240, 50, 240} + } + ,{{ 190, 80, 190, 150, 190} + ,{ 140, 10, 140, 80, 140} + ,{ 190, 60, 190, 0, 190} + ,{ 150, 80, 80, 150, 80} + ,{ 190, 60, 190, 0, 190} + } + ,{{ 240, 130, 240, 90, 240} + ,{ 240, 100, 240, 50, 240} + ,{ 210, 130, 210, 20, 210} + ,{ 240, 100, 240, 50, 240} + ,{ 150, 20, 150, 90, 150} + } + } + ,{{{ 210, 190, 210, 190, 180} + ,{ 210, 190, 210, 190, 180} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + } + ,{{ 210, 190, 210, 190, 180} + ,{ 210, 190, 210, 190, 180} + ,{ 160, 150, 160, 150, 70} + ,{ 160, 90, 160, 90, 10} + ,{ 160, 150, 160, 150, 70} + } + ,{{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + } + ,{{ 170, 150, 170, 150, 90} + ,{ 170, 100, 170, 100, 20} + ,{ 160, 150, 160, 150, 70} + ,{ 90, 40, 50, 40, 90} + ,{ 160, 150, 160, 150, 70} + } + ,{{ 210, 190, 210, 190, 120} + ,{ 210, 190, 210, 190, 120} + ,{ 180, 160, 180, 160, 90} + ,{ 210, 190, 210, 190, 120} + ,{ 120, 110, 120, 110, 30} + } + } + } + ,{{{{ 310, 290, 310, 260, 300} + ,{ 310, 270, 310, 260, 300} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 290, 290, 270, 220, 270} + } + ,{{ 300, 270, 300, 260, 300} + ,{ 300, 270, 300, 260, 300} + ,{ 270, 230, 270, 220, 270} + ,{ 230, 150, 230, 140, 220} + ,{ 270, 230, 270, 220, 270} + } + ,{{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + } + ,{{ 310, 230, 310, 220, 300} + ,{ 310, 230, 310, 220, 300} + ,{ 270, 230, 270, 220, 270} + ,{ 210, 130, 140, 210, 150} + ,{ 270, 230, 270, 220, 270} + } + ,{{ 290, 290, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 270, 230, 270, 220, 270} + ,{ 290, 290, 270, 220, 270} + } + } + ,{{{ 300, 290, 300, 190, 300} + ,{ 300, 270, 300, 170, 300} + ,{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 290, 290, 270, 190, 270} + } + ,{{ 300, 270, 300, 170, 300} + ,{ 300, 270, 300, 170, 300} + ,{ 270, 230, 270, 130, 270} + ,{ 190, 150, 190, 50, 190} + ,{ 270, 230, 270, 130, 270} + } + ,{{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 190, 270} + } + ,{{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 140, 100, 140, 130, 140} + ,{ 270, 230, 270, 130, 270} + } + ,{{ 290, 290, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 270, 230, 270, 190, 270} + ,{ 270, 230, 270, 130, 270} + ,{ 290, 290, 270, 130, 270} + } + } + ,{{{ 310, 260, 310, 260, 300} + ,{ 310, 260, 310, 260, 300} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + ,{ 250, 220, 250, 220, 240} + } + ,{{ 290, 260, 290, 260, 270} + ,{ 290, 260, 290, 260, 270} + ,{ 250, 220, 250, 220, 240} + ,{ 230, 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INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 220, 220, 190, 150, 150} + ,{ 170, 170, 150, 150, 150} + ,{ 220, 220, 190, 130, 140} + ,{ 170, 170, 150, 150, 150} + ,{ 140, 140, 120, 140, 120} + } + ,{{ 150, 130, 110, 110, 150} + ,{ 150, 130, 110, 110, 150} + ,{ 130, 130, 110, 100, 110} + ,{ 90, 10, 70, 10, 90} + ,{ 130, 130, 100, 100, 110} + } + ,{{ 220, 220, 190, 150, 150} + ,{ 150, 150, 150, 150, 150} + ,{ 220, 220, 190, 130, 140} + ,{ 170, 170, 150, 150, 150} + ,{ 140, 140, 120, 120, 120} + } + ,{{ 140, 130, 100, 100, 140} + ,{ 90, 10, 70, 10, 90} + ,{ 130, 130, 100, 100, 110} + ,{ 140, -10, 20, 80, 140} + ,{ 130, 130, 100, 100, 110} + } + ,{{ 170, 170, 170, 150, 150} + ,{ 170, 170, 150, 150, 150} + ,{ 170, 140, 170, 120, 120} + ,{ 170, 170, 150, 150, 150} + ,{ 140, 140, 30, 140, 30} + } + } + ,{{{ 220, 220, 190, 140, 140} + ,{ 170, 170, 140, 40, 140} + ,{ 220, 220, 190, 70, 130} + ,{ 170, 170, 140, 30, 140} + ,{ 140, 140, 110, 140, 110} + } + ,{{ 130, 130, 110, 70, 100} + ,{ 130, 130, 100, 40, 100} + ,{ 130, 130, 110, 70, 100} + ,{ 70, -20, 70, -50, 10} + ,{ 130, 130, 100, -10, 100} + } + ,{{ 220, 220, 190, 70, 140} + ,{ 140, 60, 50, 30, 140} + ,{ 220, 220, 190, 70, 130} + ,{ 170, 170, 140, 30, 140} + ,{ 140, 140, 110, 50, 110} + } + ,{{ 130, 130, 100, -10, 100} + ,{ 10, 0, -100, -70, 10} + ,{ 130, 130, 100, -10, 100} + ,{ -10, -10, -50, -30, -50} + ,{ 130, 130, 100, -10, 100} + } + ,{{ 170, 170, 140, 140, 140} + ,{ 170, 170, 140, 30, 140} + ,{ 140, 140, 110, 60, 110} + ,{ 170, 170, 140, 30, 140} + ,{ 140, 140, 30, 140, 20} + } + } + ,{{{ 150, 150, 150, 150, 150} + ,{ 150, 150, 150, 150, 150} + ,{ 140, 130, 130, 130, 140} + ,{ 150, 150, 150, 150, 150} + ,{ 120, 120, 120, 120, 120} + } + ,{{ 110, 110, 110, 110, 110} + ,{ 110, 110, 110, 110, 110} + ,{ 110, 100, 100, 100, 110} + ,{ 80, -40, 70, 10, 80} + ,{ 110, 100, 100, 100, 110} + } + ,{{ 150, 150, 150, 150, 150} + ,{ 150, 150, 150, 150, 150} + ,{ 140, 130, 130, 130, 140} + ,{ 150, 150, 150, 150, 150} + ,{ 120, 120, 120, 120, 120} + } + ,{{ 110, 100, 100, 100, 110} + ,{ 80, -70, -60, 10, 80} + ,{ 110, 100, 100, 100, 110} + ,{ -40, -40, -40, -40, -50} + ,{ 110, 100, 100, 100, 110} + } + ,{{ 150, 150, 150, 150, 150} + ,{ 150, 150, 150, 150, 150} + ,{ 120, 120, 120, 120, 120} + ,{ 150, 150, 150, 150, 150} + ,{ 30, 30, 30, 30, 30} + } + } + ,{{{ 140, 70, 140, 80, 140} + ,{ 140, 10, 140, 10, 140} + ,{ 130, 70, 130, 20, 130} + ,{ 140, -30, 140, 80, 140} + ,{ 110, 50, 110, 70, 110} + } + ,{{ 100, -30, 100, -30, 100} + ,{ 100, -30, 100, -30, 100} + ,{ 100, -70, 100, -40, 100} + ,{ 10, -170, 10, -30, 10} + ,{ 100, -70, 100, -40, 100} + } + ,{{ 140, 70, 140, 10, 140} + ,{ 140, 10, 140, -30, 140} + ,{ 130, 70, 130, -10, 130} + ,{ 140, -30, 140, 10, 140} + ,{ 110, 0, 110, -60, 110} + } + ,{{ 100, -70, 100, 80, 100} + ,{ 10, -160, 10, 0, 10} + ,{ 100, -70, 100, -40, 100} + ,{ 80, -90, -50, 80, -50} + ,{ 100, -70, 100, -40, 100} + } + ,{{ 140, 50, 140, 70, 140} + ,{ 140, -30, 140, 10, 140} + ,{ 110, 0, 110, 20, 110} + ,{ 140, -30, 140, 10, 140} + ,{ 70, 50, 20, 70, 20} + } + } + ,{{{ 170, 150, 170, 150, 150} + ,{ 150, 150, 150, 150, 150} + ,{ 170, 130, 170, 130, 30} + ,{ 150, 150, 150, 150, 140} + ,{ 120, 120, 120, 120, 40} + } + ,{{ 150, 110, 110, 110, 150} + ,{ 150, 110, 110, 110, 150} + ,{ 100, 100, 100, 100, -20} + ,{ 90, 10, 70, 10, 90} + ,{ 100, 100, 100, 100, 30} + } + ,{{ 150, 150, 150, 150, 70} + ,{ 150, 150, 150, 150, 0} + ,{ 130, 130, 130, 130, -10} + ,{ 150, 150, 150, 150, 70} + ,{ 120, 120, 120, 120, 40} + } + ,{{ 140, 100, 100, 100, 140} + ,{ 90, 10, 70, 10, 90} + ,{ 100, 100, 100, 100, 30} + ,{ 140, -40, 20, -40, 140} + ,{ 100, 100, 100, 100, 30} + } + ,{{ 170, 150, 170, 150, 70} + ,{ 150, 150, 150, 150, 70} + ,{ 170, 120, 170, 120, 20} + ,{ 150, 150, 150, 150, 70} + ,{ 30, 30, 30, 30, -60} + } + } + } + ,{{{{ 150, 150, 120, 120, 130} + ,{ 150, 150, 120, 120, 130} + ,{ 130, 130, 100, 100, 110} + ,{ 120, 120, 90, 90, 100} + ,{ 120, 120, 100, 100, 100} + } + ,{{ 150, 150, 120, 120, 130} + ,{ 150, 150, 120, 120, 130} + ,{ 120, 120, 100, 100, 100} + ,{ -10, -50, -20, -80, -10} + ,{ 120, 120, 100, 100, 100} + } + ,{{ 120, 120, 100, 100, 100} + ,{ 120, 120, 90, 90, 100} + ,{ 120, 120, 100, 100, 100} + ,{ 120, 120, 90, 90, 100} + ,{ 120, 120, 100, 100, 100} + } + ,{{ 120, 120, 100, 100, 100} + ,{ 50, 10, 50, -10, 50} + ,{ 120, 120, 100, 100, 100} + ,{ 80, -20, -40, 80, 10} + ,{ 120, 120, 100, 100, 100} + } + ,{{ 130, 130, 100, 100, 110} + ,{ 120, 120, 90, 90, 100} + ,{ 130, 130, 100, 100, 110} + ,{ 120, 120, 90, 90, 100} + ,{ 110, 110, 20, 20, 30} + } + } + ,{{{ 150, 150, 120, 50, 120} + ,{ 150, 150, 120, 10, 120} + ,{ 130, 130, 100, 50, 100} + ,{ 120, 120, 90, -20, 90} + ,{ 120, 120, 90, 50, 90} + } + ,{{ 150, 150, 120, 10, 120} + ,{ 150, 150, 120, 10, 120} + ,{ 120, 120, 90, -10, 90} + ,{ -50, -50, -80, -190, -80} + ,{ 120, 120, 90, -10, 90} + } + ,{{ 120, 120, 90, 50, 90} + ,{ 120, 120, 90, -20, 90} + ,{ 120, 120, 90, 50, 90} + ,{ 120, 120, 90, -20, 90} + ,{ 120, 120, 90, 50, 90} + } + ,{{ 120, 120, 90, -10, 90} + ,{ 10, 10, -20, -130, -20} + ,{ 120, 120, 90, -10, 90} + ,{ -20, -20, -50, -20, -50} + ,{ 120, 120, 90, -10, 90} + } + ,{{ 130, 130, 100, 50, 100} + ,{ 120, 120, 90, -20, 90} + ,{ 130, 130, 100, 50, 100} + ,{ 120, 120, 90, -20, 90} + ,{ 110, 110, 20, -90, 20} + } + } + ,{{{ 130, 120, 120, 120, 130} + ,{ 130, 120, 120, 120, 130} + ,{ 110, 100, 100, 100, 110} + ,{ 100, 90, 90, 90, 100} + ,{ 100, 100, 100, 100, 100} + } + ,{{ 130, 120, 120, 120, 130} + ,{ 130, 120, 120, 120, 130} + ,{ 100, 100, 100, 100, 100} + ,{ -10, -80, -20, -80, -10} + ,{ 100, 100, 100, 100, 100} + } + ,{{ 100, 100, 100, 100, 100} + ,{ 100, 90, 90, 90, 100} + ,{ 100, 100, 100, 100, 100} + ,{ 100, 90, 90, 90, 100} + ,{ 100, 100, 100, 100, 100} + } + ,{{ 100, 100, 100, 100, 100} + ,{ 50, -10, 50, -10, 50} + ,{ 100, 100, 100, 100, 100} + ,{ -40, -40, -40, -40, -40} + ,{ 100, 100, 100, 100, 100} + } + ,{{ 110, 100, 100, 100, 110} + ,{ 100, 90, 90, 90, 100} + ,{ 110, 100, 100, 100, 110} + ,{ 100, 90, 90, 90, 100} + ,{ 30, 20, 20, 20, 30} + } + } + ,{{{ 120, -10, 120, 80, 120} + ,{ 120, -50, 120, -20, 120} + ,{ 100, -10, 100, -40, 100} + ,{ 90, -80, 90, 80, 90} + ,{ 90, -20, 90, 10, 90} + } + ,{{ 120, -50, 120, -20, 120} + ,{ 120, -50, 120, -20, 120} + ,{ 90, -80, 90, -40, 90} + ,{ -80, -260, -80, -90, -80} + ,{ 90, -80, 90, -40, 90} + } + ,{{ 90, -20, 90, -40, 90} + ,{ 90, -80, 90, -50, 90} + ,{ 90, -20, 90, -40, 90} + ,{ 90, -80, 90, -50, 90} + ,{ 90, -20, 90, -40, 90} + } + ,{{ 90, -80, 90, 80, 90} + ,{ -20, -190, -20, -20, -20} + ,{ 90, -80, 90, -40, 90} + ,{ 80, -90, -50, 80, -50} + ,{ 90, -80, 90, -40, 90} + } + ,{{ 100, -10, 100, 10, 100} + ,{ 90, -80, 90, -50, 90} + ,{ 100, -10, 100, -40, 100} + ,{ 90, -80, 90, -50, 90} + ,{ 20, -150, 20, 10, 20} + } + } + ,{{{ 120, 120, 120, 120, 110} + ,{ 120, 120, 120, 120, 110} + ,{ 100, 100, 100, 100, 30} + ,{ 90, 90, 90, 90, 20} + ,{ 100, 100, 100, 100, 20} + } + ,{{ 120, 120, 120, 120, 110} + ,{ 120, 120, 120, 120, 110} + ,{ 100, 100, 100, 100, 20} + ,{ -20, -80, -20, -80, -150} + ,{ 100, 100, 100, 100, 20} + } + ,{{ 100, 100, 100, 100, 20} + ,{ 90, 90, 90, 90, 20} + ,{ 100, 100, 100, 100, 20} + ,{ 90, 90, 90, 90, 20} + ,{ 100, 100, 100, 100, 20} + } + ,{{ 100, 100, 100, 100, 20} + ,{ 50, -10, 50, -10, -90} + ,{ 100, 100, 100, 100, 20} + ,{ 10, -40, -40, -40, 10} + ,{ 100, 100, 100, 100, 20} + } + ,{{ 100, 100, 100, 100, 30} + ,{ 90, 90, 90, 90, 20} + ,{ 100, 100, 100, 100, 30} + ,{ 90, 90, 90, 90, 20} + ,{ 20, 20, 20, 20, -50} + } + } + } + ,{{{{ 300, 300, 250, 250, 260} + ,{ 280, 280, 250, 250, 260} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 300, 300, 220, 220, 220} + } + ,{{ 280, 280, 250, 250, 260} + ,{ 280, 280, 250, 250, 260} + ,{ 240, 240, 220, 220, 220} + ,{ 200, 160, 200, 140, 200} + ,{ 240, 240, 220, 220, 220} + } + ,{{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + } + ,{{ 240, 240, 240, 220, 240} + ,{ 240, 200, 240, 180, 240} + ,{ 240, 240, 220, 220, 220} + ,{ 210, 110, 90, 210, 140} + ,{ 240, 240, 220, 220, 220} + } + ,{{ 300, 300, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 300, 300, 220, 220, 220} + } + } + ,{{{ 300, 300, 250, 160, 250} + ,{ 280, 280, 250, 140, 250} + ,{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 300, 300, 210, 160, 210} + } + ,{{ 280, 280, 250, 140, 250} + ,{ 280, 280, 250, 140, 250} + ,{ 240, 240, 210, 100, 210} + ,{ 160, 160, 130, 20, 130} + ,{ 240, 240, 210, 100, 210} + } + ,{{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 160, 210} + } + ,{{ 240, 240, 210, 100, 210} + ,{ 200, 200, 170, 60, 170} + ,{ 240, 240, 210, 100, 210} + ,{ 110, 110, 80, 100, 80} + ,{ 240, 240, 210, 100, 210} + } + ,{{ 300, 300, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 300, 300, 210, 100, 210} + } + } + ,{{{ 260, 250, 250, 250, 260} + ,{ 260, 250, 250, 250, 260} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 260, 250, 250, 250, 260} + ,{ 260, 250, 250, 250, 260} + ,{ 220, 220, 220, 220, 220} + ,{ 200, 140, 200, 140, 200} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 240, 220, 240, 220, 240} + ,{ 240, 180, 240, 180, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 90, 90, 90, 90, 90} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 250, 100, 250, 210, 250} + ,{ 250, 70, 250, 170, 250} + ,{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 210, 210} + ,{ 210, 100, 210, 210, 210} + } + ,{{ 250, 70, 250, 130, 250} + ,{ 250, 70, 250, 110, 250} + ,{ 210, 40, 210, 80, 210} + ,{ 130, -40, 130, 130, 130} + ,{ 210, 40, 210, 80, 210} + } + ,{{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 100, 210, 80, 210} + } + ,{{ 210, 40, 210, 210, 210} + ,{ 170, 0, 170, 170, 170} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 40, 80, 210, 80} + ,{ 210, 40, 210, 80, 210} + } + ,{{ 210, 100, 210, 210, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 40, 210, 210, 210} + } + } + ,{{{ 250, 250, 250, 250, 240} + ,{ 250, 250, 250, 250, 240} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 250, 250, 250, 250, 240} + ,{ 250, 250, 250, 250, 240} + ,{ 220, 220, 220, 220, 140} + ,{ 200, 140, 200, 140, 60} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 240, 220, 240, 220, 140} + ,{ 240, 180, 240, 180, 100} + ,{ 220, 220, 220, 220, 140} + ,{ 140, 90, 90, 90, 140} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + } + } + } + ,{{{{ 280, 270, 280, 220, 280} + ,{ 280, 240, 280, 220, 280} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 270, 270, 190, 190, 190} + } + ,{{ 210, 210, 190, 190, 190} + ,{ 190, 190, 150, 150, 160} + ,{ 210, 210, 190, 190, 190} + ,{ 120, 80, 110, 50, 120} + ,{ 210, 210, 190, 190, 190} + } + ,{{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + } + ,{{ 280, 240, 280, 220, 280} + ,{ 280, 240, 280, 220, 280} + ,{ 210, 210, 190, 190, 190} + ,{ 180, 80, 60, 180, 110} + ,{ 210, 210, 190, 190, 190} + } + ,{{ 270, 270, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 270, 270, 190, 190, 190} + } + } + ,{{{ 270, 270, 210, 130, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 270, 270, 180, 130, 180} + } + ,{{ 210, 210, 180, 70, 180} + ,{ 190, 190, 150, 40, 150} + ,{ 210, 210, 180, 70, 180} + ,{ 80, 80, 50, -60, 50} + ,{ 210, 210, 180, 70, 180} + } + ,{{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 130, 180} + } + ,{{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 210, 210, 180, 70, 180} + ,{ 80, 80, 50, 70, 50} + ,{ 210, 210, 180, 70, 180} + } + ,{{ 270, 270, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 270, 270, 180, 70, 180} + } + } + ,{{{ 280, 220, 280, 220, 280} + ,{ 280, 220, 280, 220, 280} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 160, 150, 150, 150, 160} + ,{ 190, 190, 190, 190, 190} + ,{ 120, 50, 110, 50, 120} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 280, 220, 280, 220, 280} + ,{ 280, 220, 280, 220, 280} + ,{ 190, 190, 190, 190, 190} + ,{ 60, 60, 60, 60, 60} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + } + } + ,{{{ 210, 70, 210, 210, 210} + ,{ 210, 40, 210, 210, 210} + ,{ 180, 70, 180, 50, 180} + ,{ 180, 10, 180, 180, 180} + ,{ 180, 70, 180, 180, 180} + } + ,{{ 180, 10, 180, 50, 180} + ,{ 150, -20, 150, 10, 150} + ,{ 180, 10, 180, 50, 180} + ,{ 50, -120, 50, 40, 50} + ,{ 180, 10, 180, 50, 180} + } + ,{{ 180, 70, 180, 50, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 180, 70, 180, 50, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 180, 70, 180, 50, 180} + } + ,{{ 210, 40, 210, 210, 210} + ,{ 210, 40, 210, 210, 210} + ,{ 180, 10, 180, 50, 180} + ,{ 180, 10, 50, 180, 50} + ,{ 180, 10, 180, 50, 180} + } + ,{{ 180, 70, 180, 180, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 180, 70, 180, 50, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 180, 10, 180, 180, 180} + } + } + ,{{{ 280, 220, 280, 220, 140} + ,{ 280, 220, 280, 220, 140} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + } + ,{{ 190, 190, 190, 190, 140} + ,{ 150, 150, 150, 150, 140} + ,{ 190, 190, 190, 190, 110} + ,{ 110, 50, 110, 50, -20} + ,{ 190, 190, 190, 190, 110} + } + ,{{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + } + ,{{ 280, 220, 280, 220, 140} + ,{ 280, 220, 280, 220, 140} + ,{ 190, 190, 190, 190, 110} + ,{ 110, 60, 60, 60, 110} + ,{ 190, 190, 190, 190, 110} + } + ,{{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + } + } + } + ,{{{{ 210, 210, 190, 190, 200} + ,{ 210, 210, 190, 190, 200} + ,{ 190, 190, 170, 170, 170} + ,{ 200, 200, 170, 170, 180} + ,{ 190, 190, 170, 170, 170} + } + ,{{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 190, 190, 160, 160, 170} + ,{ 130, 90, 120, 60, 130} + ,{ 190, 190, 160, 160, 170} + } + ,{{ 200, 200, 170, 170, 180} + ,{ 200, 200, 170, 170, 180} + ,{ 190, 190, 170, 170, 170} + ,{ 200, 200, 170, 170, 180} + ,{ 190, 190, 170, 170, 170} + } + ,{{ 200, 190, 190, 160, 200} + ,{ 200, 160, 190, 130, 200} + ,{ 190, 190, 160, 160, 170} + ,{ 130, 40, 10, 130, 70} + ,{ 190, 190, 160, 160, 170} + } + ,{{ 200, 200, 170, 170, 180} + ,{ 200, 200, 170, 170, 180} + ,{ 190, 190, 170, 170, 170} + ,{ 200, 200, 170, 170, 180} + ,{ 160, 160, 80, 80, 80} + } + } + ,{{{ 210, 210, 180, 110, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 190, 190, 160, 110, 160} + ,{ 200, 200, 170, 60, 170} + ,{ 190, 190, 160, 110, 160} + } + ,{{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 190, 190, 160, 50, 160} + ,{ 90, 90, 60, -50, 60} + ,{ 190, 190, 160, 50, 160} + } + ,{{ 200, 200, 170, 110, 170} + ,{ 200, 200, 170, 60, 170} + ,{ 190, 190, 160, 110, 160} + ,{ 200, 200, 170, 60, 170} + ,{ 190, 190, 160, 110, 160} + } + ,{{ 190, 190, 160, 50, 160} + ,{ 160, 160, 130, 20, 130} + ,{ 190, 190, 160, 50, 160} + ,{ 40, 40, 10, 30, 10} + ,{ 190, 190, 160, 50, 160} + } + ,{{ 200, 200, 170, 110, 170} + ,{ 200, 200, 170, 60, 170} + ,{ 190, 190, 160, 110, 160} + ,{ 200, 200, 170, 60, 170} + ,{ 160, 160, 70, -30, 70} + } + } + ,{{{ 200, 190, 190, 190, 200} + ,{ 200, 190, 190, 190, 200} + ,{ 170, 170, 170, 170, 170} + ,{ 180, 170, 170, 170, 180} + ,{ 170, 170, 170, 170, 170} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 170, 160, 160, 160, 170} + ,{ 130, 60, 120, 60, 130} + ,{ 170, 160, 160, 160, 170} + } + ,{{ 180, 170, 170, 170, 180} + ,{ 180, 170, 170, 170, 180} + ,{ 170, 170, 170, 170, 170} + ,{ 180, 170, 170, 170, 180} + ,{ 170, 170, 170, 170, 170} + } + ,{{ 200, 160, 190, 160, 200} + ,{ 200, 130, 190, 130, 200} + ,{ 170, 160, 160, 160, 170} + ,{ 20, 10, 10, 10, 20} + ,{ 170, 160, 160, 160, 170} + } + ,{{ 180, 170, 170, 170, 180} + ,{ 180, 170, 170, 170, 180} + ,{ 170, 170, 170, 170, 170} + ,{ 180, 170, 170, 170, 180} + ,{ 80, 80, 80, 80, 80} + } + } + ,{{{ 180, 50, 180, 130, 180} + ,{ 180, 10, 180, 120, 180} + ,{ 160, 50, 160, 30, 160} + ,{ 170, 0, 170, 130, 170} + ,{ 160, 50, 160, 70, 160} + } + ,{{ 180, 10, 180, 50, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 160, -10, 160, 20, 160} + ,{ 60, -110, 60, 50, 60} + ,{ 160, -10, 160, 20, 160} + } + ,{{ 170, 50, 170, 30, 170} + ,{ 170, 0, 170, 30, 170} + ,{ 160, 50, 160, 30, 160} + ,{ 170, 0, 170, 30, 170} + ,{ 160, 50, 160, 30, 160} + } + ,{{ 160, -10, 160, 130, 160} + ,{ 130, -40, 130, 120, 130} + ,{ 160, -10, 160, 20, 160} + ,{ 130, -30, 10, 130, 10} + ,{ 160, -10, 160, 20, 160} + } + ,{{ 170, 50, 170, 70, 170} + ,{ 170, 0, 170, 30, 170} + ,{ 160, 50, 160, 30, 160} + ,{ 170, 0, 170, 30, 170} + ,{ 70, -100, 70, 70, 70} + } + } + ,{{{ 190, 190, 190, 190, 170} + ,{ 190, 190, 190, 190, 170} + ,{ 170, 170, 170, 170, 90} + ,{ 170, 170, 170, 170, 100} + ,{ 170, 170, 170, 170, 90} + } + ,{{ 190, 190, 190, 190, 170} + ,{ 190, 190, 190, 190, 170} + ,{ 160, 160, 160, 160, 90} + ,{ 120, 60, 120, 60, -10} + ,{ 160, 160, 160, 160, 90} + } + ,{{ 170, 170, 170, 170, 100} + ,{ 170, 170, 170, 170, 100} + ,{ 170, 170, 170, 170, 90} + ,{ 170, 170, 170, 170, 100} + ,{ 170, 170, 170, 170, 90} + } + ,{{ 190, 160, 190, 160, 90} + ,{ 190, 130, 190, 130, 60} + ,{ 160, 160, 160, 160, 90} + ,{ 70, 10, 10, 10, 70} + ,{ 160, 160, 160, 160, 90} + } + ,{{ 170, 170, 170, 170, 100} + ,{ 170, 170, 170, 170, 100} + ,{ 170, 170, 170, 170, 90} + ,{ 170, 170, 170, 170, 100} + ,{ 80, 80, 80, 80, 0} + } + } + } + ,{{{{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + } + ,{{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 170, 170, 140, 140, 150} + ,{ 150, 110, 140, 80, 150} + ,{ 170, 170, 140, 140, 150} + } + ,{{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + } + ,{{ 170, 170, 150, 150, 160} + ,{ 160, 120, 150, 90, 160} + ,{ 170, 170, 140, 140, 150} + ,{ 150, 60, 30, 150, 90} + ,{ 170, 170, 140, 140, 150} + } + ,{{ 210, 210, 190, 190, 190} + ,{ 210, 210, 190, 190, 190} + ,{ 180, 180, 160, 160, 160} + ,{ 210, 210, 190, 190, 190} + ,{ 190, 190, 100, 100, 110} + } + } + ,{{{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 130, 180} + } + ,{{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 170, 170, 140, 30, 140} + ,{ 110, 110, 80, -30, 80} + ,{ 170, 170, 140, 30, 140} + } + ,{{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 130, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 210, 210, 180, 130, 180} + } + ,{{ 170, 170, 140, 50, 140} + ,{ 120, 120, 90, -20, 90} + ,{ 170, 170, 140, 30, 140} + ,{ 60, 60, 30, 50, 30} + ,{ 170, 170, 140, 30, 140} + } + ,{{ 210, 210, 180, 100, 180} + ,{ 210, 210, 180, 70, 180} + ,{ 180, 180, 150, 100, 150} + ,{ 210, 210, 180, 70, 180} + ,{ 190, 190, 100, -10, 100} + } + } + ,{{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 150, 140, 140, 140, 150} + ,{ 150, 80, 140, 80, 150} + ,{ 150, 140, 140, 140, 150} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 160, 140, 150, 140, 160} + ,{ 160, 90, 150, 90, 160} + ,{ 150, 140, 140, 140, 150} + ,{ 40, 30, 30, 30, 40} + ,{ 150, 140, 140, 140, 150} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 190, 190, 190, 190, 190} + ,{ 160, 160, 160, 160, 160} + ,{ 190, 190, 190, 190, 190} + ,{ 110, 100, 100, 100, 110} + } + } + ,{{{ 180, 70, 180, 150, 180} + ,{ 180, 10, 180, 80, 180} + ,{ 180, 70, 180, 50, 180} + ,{ 180, 10, 180, 150, 180} + ,{ 180, 70, 180, 90, 180} + } + ,{{ 180, 10, 180, 70, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 140, -30, 140, 0, 140} + ,{ 80, -90, 80, 70, 80} + ,{ 140, -30, 140, 0, 140} + } + ,{{ 180, 70, 180, 50, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 180, 70, 180, 50, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 180, 70, 180, 50, 180} + } + ,{{ 150, -10, 140, 150, 140} + ,{ 90, -80, 90, 80, 90} + ,{ 140, -30, 140, 0, 140} + ,{ 150, -10, 30, 150, 30} + ,{ 140, -30, 140, 0, 140} + } + ,{{ 180, 40, 180, 90, 180} + ,{ 180, 10, 180, 50, 180} + ,{ 150, 40, 150, 20, 150} + ,{ 180, 10, 180, 50, 180} + ,{ 100, -70, 100, 90, 100} + } + } + ,{{{ 190, 190, 190, 190, 170} + ,{ 190, 190, 190, 190, 170} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + } + ,{{ 190, 190, 190, 190, 170} + ,{ 190, 190, 190, 190, 170} + ,{ 140, 140, 140, 140, 70} + ,{ 140, 80, 140, 80, 10} + ,{ 140, 140, 140, 140, 70} + } + ,{{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + } + ,{{ 150, 140, 150, 140, 90} + ,{ 150, 90, 150, 90, 20} + ,{ 140, 140, 140, 140, 70} + ,{ 90, 30, 30, 30, 90} + ,{ 140, 140, 140, 140, 70} + } + ,{{ 190, 190, 190, 190, 110} + ,{ 190, 190, 190, 190, 110} + ,{ 160, 160, 160, 160, 80} + ,{ 190, 190, 190, 190, 110} + ,{ 100, 100, 100, 100, 30} + } + } + } + ,{{{{ 300, 300, 280, 250, 280} + ,{ 280, 280, 280, 250, 280} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 300, 300, 220, 220, 220} + } + ,{{ 280, 280, 250, 250, 260} + ,{ 280, 280, 250, 250, 260} + ,{ 240, 240, 220, 220, 220} + ,{ 200, 160, 200, 140, 200} + ,{ 240, 240, 220, 220, 220} + } + ,{{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + } + ,{{ 280, 240, 280, 220, 280} + ,{ 280, 240, 280, 220, 280} + ,{ 240, 240, 220, 220, 220} + ,{ 210, 110, 90, 210, 140} + ,{ 240, 240, 220, 220, 220} + } + ,{{ 300, 300, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 240, 240, 220, 220, 220} + ,{ 300, 300, 220, 220, 220} + } + } + ,{{{ 300, 300, 250, 160, 250} + ,{ 280, 280, 250, 140, 250} + ,{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 300, 300, 210, 160, 210} + } + ,{{ 280, 280, 250, 140, 250} + ,{ 280, 280, 250, 140, 250} + ,{ 240, 240, 210, 100, 210} + ,{ 160, 160, 130, 20, 130} + ,{ 240, 240, 210, 100, 210} + } + ,{{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 160, 210} + } + ,{{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 110, 110, 80, 100, 80} + ,{ 240, 240, 210, 100, 210} + } + ,{{ 300, 300, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 240, 240, 210, 160, 210} + ,{ 240, 240, 210, 100, 210} + ,{ 300, 300, 210, 140, 210} + } + } + ,{{{ 280, 250, 280, 250, 280} + ,{ 280, 250, 280, 250, 280} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 260, 250, 250, 250, 260} + ,{ 260, 250, 250, 250, 260} + ,{ 220, 220, 220, 220, 220} + ,{ 200, 140, 200, 140, 200} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 280, 220, 280, 220, 280} + ,{ 280, 220, 280, 220, 280} + ,{ 220, 220, 220, 220, 220} + ,{ 90, 90, 90, 90, 90} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 250, 100, 250, 210, 250} + ,{ 250, 70, 250, 210, 250} + ,{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 210, 210} + ,{ 210, 100, 210, 210, 210} + } + ,{{ 250, 70, 250, 130, 250} + ,{ 250, 70, 250, 110, 250} + ,{ 210, 40, 210, 80, 210} + ,{ 130, -40, 130, 130, 130} + ,{ 210, 40, 210, 80, 210} + } + ,{{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 100, 210, 80, 210} + } + ,{{ 210, 40, 210, 210, 210} + ,{ 210, 40, 210, 210, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 40, 80, 210, 80} + ,{ 210, 40, 210, 80, 210} + } + ,{{ 210, 100, 210, 210, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 100, 210, 80, 210} + ,{ 210, 40, 210, 80, 210} + ,{ 210, 50, 210, 210, 210} + } + } + ,{{{ 280, 250, 280, 250, 240} + ,{ 280, 250, 280, 250, 240} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 250, 250, 250, 250, 240} + ,{ 250, 250, 250, 250, 240} + ,{ 220, 220, 220, 220, 140} + ,{ 200, 140, 200, 140, 90} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 280, 220, 280, 220, 140} + ,{ 280, 220, 280, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 140, 90, 90, 90, 140} + ,{ 220, 220, 220, 220, 140} + } + ,{{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + ,{ 220, 220, 220, 220, 140} + } + } + } + } +,{{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 300, 300, 270, 270, 290} + ,{ 300, 300, 270, 270, 290} + ,{ 290, 290, 250, 270, 250} + ,{ 300, 300, 270, 270, 270} + ,{ 270, 270, 240, 260, 240} + } + ,{{ 290, 270, 230, 230, 290} + ,{ 290, 270, 230, 230, 290} + ,{ 260, 260, 220, 220, 220} + ,{ 190, 170, 190, 130, 190} + ,{ 260, 260, 220, 220, 220} + } + ,{{ 300, 300, 270, 270, 270} + ,{ 300, 300, 270, 270, 270} + ,{ 290, 290, 250, 270, 250} + ,{ 300, 300, 270, 270, 270} + ,{ 270, 270, 240, 260, 240} + } + ,{{ 260, 260, 220, 220, 220} + ,{ 190, 170, 190, 130, 190} + ,{ 260, 260, 220, 220, 220} + ,{ 210, 130, 80, 210, 210} + ,{ 260, 260, 220, 220, 220} + } + ,{{ 300, 300, 270, 270, 270} + ,{ 300, 300, 270, 270, 270} + ,{ 270, 270, 240, 260, 240} + ,{ 300, 300, 270, 270, 270} + ,{ 240, 240, 150, 150, 150} + } + } + ,{{{ 300, 300, 270, 270, 270} + ,{ 300, 300, 270, 230, 270} + ,{ 290, 290, 250, 270, 250} + ,{ 300, 300, 270, 230, 270} + ,{ 270, 270, 240, 260, 240} + } + ,{{ 270, 270, 230, 190, 230} + ,{ 270, 270, 230, 190, 230} + ,{ 260, 260, 220, 180, 220} + ,{ 170, 170, 130, 90, 130} + ,{ 260, 260, 220, 180, 220} + } + ,{{ 300, 300, 270, 270, 270} + ,{ 300, 300, 270, 230, 270} + ,{ 290, 290, 250, 270, 250} + ,{ 300, 300, 270, 230, 270} + ,{ 270, 270, 240, 260, 240} + } + ,{{ 260, 260, 220, 180, 220} + ,{ 170, 170, 130, 90, 130} + ,{ 260, 260, 220, 180, 220} + ,{ 170, 110, 80, 170, 80} + ,{ 260, 260, 220, 180, 220} + } + ,{{ 300, 300, 270, 260, 270} + ,{ 300, 300, 270, 230, 270} + ,{ 270, 270, 240, 260, 240} + ,{ 300, 300, 270, 230, 270} + ,{ 240, 240, 150, 110, 150} + } + } + ,{{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 190} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 190} + ,{ 220, 220, 220, 220, 220} + ,{ 80, 80, 80, 80, 80} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + ,{ 270, 270, 270, 270, 270} + ,{ 150, 150, 150, 150, 150} + } + } + ,{{{ 270, 230, 270, 210, 270} + ,{ 270, 190, 270, 140, 270} + ,{ 250, 230, 250, 120, 250} + ,{ 270, 190, 270, 210, 270} + ,{ 240, 220, 240, 150, 240} + } + ,{{ 230, 150, 230, 130, 230} + ,{ 230, 150, 230, 100, 230} + ,{ 220, 140, 220, 90, 220} + ,{ 130, 50, 130, 130, 130} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 270, 230, 270, 140, 270} + ,{ 270, 190, 270, 140, 270} + ,{ 250, 230, 250, 120, 250} + ,{ 270, 190, 270, 140, 270} + ,{ 240, 220, 240, 110, 240} + } + ,{{ 220, 140, 220, 210, 220} + ,{ 130, 50, 130, 130, 130} + ,{ 220, 140, 220, 90, 220} + ,{ 210, 130, 80, 210, 80} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 270, 220, 270, 150, 270} + ,{ 270, 190, 270, 140, 270} + ,{ 240, 220, 240, 110, 240} + ,{ 270, 190, 270, 140, 270} + ,{ 150, 70, 150, 150, 150} + } + } + ,{{{ 290, 270, 270, 270, 290} + ,{ 290, 270, 270, 270, 290} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 290, 230, 230, 230, 290} + ,{ 290, 230, 230, 230, 290} + ,{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 130} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 130} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 80, 80, 80, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + ,{ 270, 270, 270, 270, 270} + ,{ 150, 150, 150, 150, 150} + } + } + } + ,{{{{ 300, 280, 240, 240, 300} + ,{ 300, 280, 240, 240, 300} + ,{ 260, 260, 220, 240, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 250, 250, 220, 240, 220} + } + ,{{ 300, 280, 240, 240, 300} + ,{ 300, 280, 240, 240, 300} + ,{ 250, 250, 220, 220, 220} + ,{ 100, 70, 100, 40, 100} + ,{ 250, 250, 220, 220, 220} + } + ,{{ 250, 250, 220, 240, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 250, 250, 220, 240, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 250, 250, 220, 240, 220} + } + ,{{ 250, 250, 220, 220, 220} + ,{ 160, 140, 160, 100, 160} + ,{ 250, 250, 220, 220, 220} + ,{ 210, 130, 80, 210, 210} + ,{ 250, 250, 220, 220, 220} + } + ,{{ 260, 260, 220, 240, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 260, 260, 220, 240, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 240, 240, 140, 140, 140} + } + } + ,{{{ 280, 280, 240, 240, 240} + ,{ 280, 280, 240, 200, 240} + ,{ 260, 260, 220, 240, 220} + ,{ 250, 250, 210, 170, 210} + ,{ 250, 250, 220, 240, 220} + } + ,{{ 280, 280, 240, 200, 240} + ,{ 280, 280, 240, 200, 240} + ,{ 250, 250, 220, 180, 220} + ,{ 70, 70, 40, 0, 40} + ,{ 250, 250, 220, 180, 220} + } + ,{{ 250, 250, 220, 240, 220} + ,{ 250, 250, 210, 170, 210} + ,{ 250, 250, 220, 240, 220} + ,{ 250, 250, 210, 170, 210} + ,{ 250, 250, 220, 240, 220} + } + ,{{ 250, 250, 220, 180, 220} + ,{ 140, 140, 100, 60, 100} + ,{ 250, 250, 220, 180, 220} + ,{ 170, 110, 80, 170, 80} + ,{ 250, 250, 220, 180, 220} + } + ,{{ 260, 260, 220, 240, 220} + ,{ 250, 250, 210, 170, 210} + ,{ 260, 260, 220, 240, 220} + ,{ 250, 250, 210, 170, 210} + ,{ 240, 240, 140, 100, 140} + } + } + ,{{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 100, 40, 100, 40, 100} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 160, 100, 160, 100, 160} + ,{ 220, 220, 220, 220, 220} + ,{ 80, 80, 80, 80, 80} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 140, 140, 140, 140, 140} + } + } + ,{{{ 240, 200, 240, 210, 240} + ,{ 240, 160, 240, 110, 240} + ,{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 210, 210} + ,{ 220, 200, 220, 140, 220} + } + ,{{ 240, 160, 240, 110, 240} + ,{ 240, 160, 240, 110, 240} + ,{ 220, 140, 220, 90, 220} + ,{ 40, -40, 40, 40, 40} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 220, 200, 220, 90, 220} + } + ,{{ 220, 140, 220, 210, 220} + ,{ 100, 20, 100, 100, 100} + ,{ 220, 140, 220, 90, 220} + ,{ 210, 130, 80, 210, 80} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 220, 200, 220, 140, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 140, 60, 140, 140, 140} + } + } + ,{{{ 300, 240, 240, 240, 300} + ,{ 300, 240, 240, 240, 300} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 300, 240, 240, 240, 300} + ,{ 300, 240, 240, 240, 300} + ,{ 220, 220, 220, 220, 220} + ,{ 100, 40, 100, 40, 40} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 160, 100, 160, 100, 100} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 80, 80, 80, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 140, 140, 140, 140, 140} + } + } + } + ,{{{{ 430, 430, 370, 370, 430} + ,{ 430, 410, 370, 370, 430} + ,{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 360, 340} + } + ,{{ 430, 410, 370, 370, 430} + ,{ 430, 410, 370, 370, 430} + ,{ 370, 370, 340, 340, 340} + ,{ 320, 290, 320, 260, 320} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 370, 370, 340, 360, 340} + } + ,{{ 370, 370, 360, 340, 360} + ,{ 360, 330, 360, 300, 360} + ,{ 370, 370, 340, 340, 340} + ,{ 340, 260, 210, 340, 340} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 430, 430, 340, 360, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 340, 340} + } + } + ,{{{ 430, 430, 370, 360, 370} + ,{ 410, 410, 370, 330, 370} + ,{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 300, 340} + ,{ 430, 430, 340, 360, 340} + } + ,{{ 410, 410, 370, 330, 370} + ,{ 410, 410, 370, 330, 370} + ,{ 370, 370, 340, 300, 340} + ,{ 290, 290, 260, 220, 260} + ,{ 370, 370, 340, 300, 340} + } + ,{{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 300, 340} + ,{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 300, 340} + ,{ 370, 370, 340, 360, 340} + } + ,{{ 370, 370, 340, 300, 340} + ,{ 330, 330, 300, 260, 300} + ,{ 370, 370, 340, 300, 340} + ,{ 300, 240, 210, 300, 210} + ,{ 370, 370, 340, 300, 340} + } + ,{{ 430, 430, 340, 360, 340} + ,{ 370, 370, 340, 300, 340} + ,{ 370, 370, 340, 360, 340} + ,{ 370, 370, 340, 300, 340} + ,{ 430, 430, 340, 300, 340} + } + } + ,{{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 340, 340, 340, 340, 340} + ,{ 320, 260, 320, 260, 320} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 360, 340, 360, 340, 360} + ,{ 360, 300, 360, 300, 360} + ,{ 340, 340, 340, 340, 340} + ,{ 210, 210, 210, 210, 210} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 370, 320, 370, 340, 370} + ,{ 370, 290, 370, 300, 370} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 340, 340} + ,{ 340, 320, 340, 340, 340} + } + ,{{ 370, 290, 370, 260, 370} + ,{ 370, 290, 370, 240, 370} + ,{ 340, 260, 340, 210, 340} + ,{ 260, 180, 260, 260, 260} + ,{ 340, 260, 340, 210, 340} + } + ,{{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + } + ,{{ 340, 260, 340, 340, 340} + ,{ 300, 220, 300, 300, 300} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 260, 210, 340, 210} + ,{ 340, 260, 340, 210, 340} + } + ,{{ 340, 320, 340, 340, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 260, 340, 340, 340} + } + } + ,{{{ 430, 370, 370, 370, 430} + ,{ 430, 370, 370, 370, 430} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 430, 370, 370, 370, 430} + ,{ 430, 370, 370, 370, 430} + ,{ 340, 340, 340, 340, 340} + ,{ 320, 260, 320, 260, 260} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 360, 340, 360, 340, 340} + ,{ 360, 300, 360, 300, 300} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 210, 210, 210, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + } + } + ,{{{{ 400, 400, 400, 360, 400} + ,{ 400, 370, 400, 360, 400} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 400, 400, 310, 330, 310} + } + ,{{ 360, 360, 310, 360, 330} + ,{ 360, 360, 270, 360, 330} + ,{ 340, 340, 310, 310, 310} + ,{ 230, 220, 230, 170, 230} + ,{ 340, 340, 310, 310, 310} + } + ,{{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 330, 310} + } + ,{{ 400, 370, 400, 340, 400} + ,{ 400, 370, 400, 340, 400} + ,{ 340, 340, 310, 310, 310} + ,{ 310, 230, 180, 310, 310} + ,{ 340, 340, 310, 310, 310} + } + ,{{ 400, 400, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 400, 400, 310, 310, 310} + } + } + ,{{{ 400, 400, 340, 360, 340} + ,{ 370, 370, 340, 360, 340} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 400, 400, 310, 330, 310} + } + ,{{ 360, 360, 310, 360, 310} + ,{ 360, 360, 270, 360, 270} + ,{ 340, 340, 310, 270, 310} + ,{ 220, 220, 170, 130, 170} + ,{ 340, 340, 310, 270, 310} + } + ,{{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 330, 310} + } + ,{{ 370, 370, 340, 300, 340} + ,{ 370, 370, 340, 300, 340} + ,{ 340, 340, 310, 270, 310} + ,{ 270, 210, 180, 270, 180} + ,{ 340, 340, 310, 270, 310} + } + ,{{ 400, 400, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 400, 400, 310, 270, 310} + } + } + ,{{{ 400, 340, 400, 340, 400} + ,{ 400, 340, 400, 340, 400} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 270, 270, 270, 270, 270} + ,{ 310, 310, 310, 310, 310} + ,{ 230, 170, 230, 170, 230} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 400, 340, 400, 340, 400} + ,{ 400, 340, 400, 340, 400} + ,{ 310, 310, 310, 310, 310} + ,{ 180, 180, 180, 180, 180} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + } + ,{{{ 340, 290, 340, 340, 340} + ,{ 340, 260, 340, 340, 340} + ,{ 310, 290, 310, 180, 310} + ,{ 310, 230, 310, 310, 310} + ,{ 310, 290, 310, 310, 310} + } + ,{{ 310, 230, 310, 180, 310} + ,{ 270, 190, 270, 140, 270} + ,{ 310, 230, 310, 180, 310} + ,{ 170, 20, 170, 170, 170} + ,{ 310, 230, 310, 180, 310} + } + ,{{ 310, 290, 310, 180, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 310, 290, 310, 180, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 310, 290, 310, 180, 310} + } + ,{{ 340, 260, 340, 340, 340} + ,{ 340, 260, 340, 340, 340} + ,{ 310, 230, 310, 180, 310} + ,{ 310, 230, 180, 310, 180} + ,{ 310, 230, 310, 180, 310} + } + ,{{ 310, 290, 310, 310, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 310, 290, 310, 180, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 310, 230, 310, 310, 310} + } + } + ,{{{ 400, 340, 400, 340, 340} + ,{ 400, 340, 400, 340, 340} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 330, 310, 310, 310, 330} + ,{ 330, 270, 270, 270, 330} + ,{ 310, 310, 310, 310, 310} + ,{ 230, 170, 230, 170, 170} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 400, 340, 400, 340, 340} + ,{ 400, 340, 400, 340, 340} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 180, 180, 180, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + } + } + ,{{{{ 370, 340, 310, 310, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 320, 320, 290, 310, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 320, 320, 290, 310, 290} + } + ,{{ 370, 340, 310, 310, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 320, 320, 280, 280, 280} + ,{ 240, 220, 240, 180, 240} + ,{ 320, 320, 280, 280, 280} + } + ,{{ 330, 330, 290, 310, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 320, 320, 290, 310, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 320, 320, 290, 310, 290} + } + ,{{ 320, 320, 310, 280, 310} + ,{ 310, 290, 310, 250, 310} + ,{ 320, 320, 280, 280, 280} + ,{ 260, 180, 130, 260, 260} + ,{ 320, 320, 280, 280, 280} + } + ,{{ 330, 330, 290, 310, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 320, 320, 290, 310, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 290, 290, 200, 200, 200} + } + } + ,{{{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 320, 320, 290, 310, 290} + ,{ 330, 330, 290, 250, 290} + ,{ 320, 320, 290, 310, 290} + } + ,{{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 320, 320, 280, 240, 280} + ,{ 220, 220, 180, 140, 180} + ,{ 320, 320, 280, 240, 280} + } + ,{{ 330, 330, 290, 310, 290} + ,{ 330, 330, 290, 250, 290} + ,{ 320, 320, 290, 310, 290} + ,{ 330, 330, 290, 250, 290} + ,{ 320, 320, 290, 310, 290} + } + ,{{ 320, 320, 280, 240, 280} + ,{ 290, 290, 250, 210, 250} + ,{ 320, 320, 280, 240, 280} + ,{ 220, 170, 130, 220, 130} + ,{ 320, 320, 280, 240, 280} + } + ,{{ 330, 330, 290, 310, 290} + ,{ 330, 330, 290, 250, 290} + ,{ 320, 320, 290, 310, 290} + ,{ 330, 330, 290, 250, 290} + ,{ 290, 290, 200, 160, 200} + } + } + ,{{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 280, 280, 280, 280, 280} + ,{ 240, 180, 240, 180, 240} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 310, 280, 310, 280, 310} + ,{ 310, 250, 310, 250, 310} + ,{ 280, 280, 280, 280, 280} + ,{ 130, 130, 130, 130, 130} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 200, 200, 200, 200, 200} + } + } + ,{{{ 310, 270, 310, 260, 310} + ,{ 310, 230, 310, 250, 310} + ,{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 260, 290} + ,{ 290, 270, 290, 200, 290} + } + ,{{ 310, 230, 310, 180, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 280, 200, 280, 150, 280} + ,{ 180, 100, 180, 180, 180} + ,{ 280, 200, 280, 150, 280} + } + ,{{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 290, 270, 290, 160, 290} + } + ,{{ 280, 200, 280, 260, 280} + ,{ 250, 170, 250, 250, 250} + ,{ 280, 200, 280, 150, 280} + ,{ 260, 180, 130, 260, 130} + ,{ 280, 200, 280, 150, 280} + } + ,{{ 290, 270, 290, 200, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 200, 120, 200, 200, 200} + } + } + ,{{{ 370, 310, 310, 310, 370} + ,{ 370, 310, 310, 310, 370} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 370, 310, 310, 310, 370} + ,{ 370, 310, 310, 310, 370} + ,{ 280, 280, 280, 280, 280} + ,{ 240, 180, 240, 180, 180} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 310, 280, 310, 280, 280} + ,{ 310, 250, 310, 250, 250} + ,{ 280, 280, 280, 280, 280} + ,{ 260, 130, 130, 130, 260} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 200, 200, 200, 200, 200} + } + } + } + ,{{{{ 370, 340, 310, 330, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 330, 310} + } + ,{{ 370, 340, 310, 310, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 300, 300, 260, 260, 260} + ,{ 260, 240, 260, 200, 260} + ,{ 300, 300, 260, 260, 260} + } + ,{{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 330, 310} + } + ,{{ 300, 300, 270, 280, 280} + ,{ 270, 250, 270, 210, 270} + ,{ 300, 300, 260, 260, 260} + ,{ 280, 200, 150, 280, 280} + ,{ 300, 300, 260, 260, 260} + } + ,{{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 310, 310, 280, 300, 280} + ,{ 340, 340, 310, 310, 310} + ,{ 320, 320, 220, 220, 220} + } + } + ,{{{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 330, 310} + } + ,{{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 300, 300, 260, 220, 260} + ,{ 240, 240, 200, 160, 200} + ,{ 300, 300, 260, 220, 260} + } + ,{{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 330, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 340, 340, 310, 330, 310} + } + ,{{ 300, 300, 260, 240, 260} + ,{ 250, 250, 210, 170, 210} + ,{ 300, 300, 260, 220, 260} + ,{ 240, 190, 150, 240, 150} + ,{ 300, 300, 260, 220, 260} + } + ,{{ 340, 340, 310, 300, 310} + ,{ 340, 340, 310, 270, 310} + ,{ 310, 310, 280, 300, 280} + ,{ 340, 340, 310, 270, 310} + ,{ 320, 320, 220, 180, 220} + } + } + ,{{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 200, 260, 200, 260} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 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INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 310, 240, 240, 310, 260} + ,{ 270, 240, 240, 270, 260} + ,{ 310, 220, 220, 310, 220} + ,{ 270, 240, 240, 270, 240} + ,{ 300, 210, 210, 300, 210} + } + ,{{ 260, 200, 200, 230, 260} + ,{ 260, 200, 200, 230, 260} + ,{ 220, 190, 190, 220, 190} + ,{ 160, 100, 160, 130, 160} + ,{ 220, 190, 190, 220, 190} + } + ,{{ 310, 240, 240, 310, 240} + ,{ 270, 240, 240, 270, 240} + ,{ 310, 220, 220, 310, 220} + ,{ 270, 240, 240, 270, 240} + ,{ 300, 210, 210, 300, 210} + } + ,{{ 220, 190, 190, 220, 190} + ,{ 160, 100, 160, 130, 160} + ,{ 220, 190, 190, 220, 190} + ,{ 210, 50, 50, 210, 180} + ,{ 220, 190, 190, 220, 190} + } + ,{{ 300, 240, 240, 300, 240} + ,{ 270, 240, 240, 270, 240} + ,{ 300, 210, 210, 300, 210} + ,{ 270, 240, 240, 270, 240} + ,{ 150, 140, 120, 150, 120} + } + } + ,{{{ 310, 200, 240, 310, 240} + ,{ 270, 200, 240, 270, 240} + ,{ 310, 190, 220, 310, 220} + ,{ 270, 200, 240, 270, 240} + ,{ 300, 170, 210, 300, 210} + } + ,{{ 230, 160, 200, 230, 200} + ,{ 230, 160, 200, 230, 200} + ,{ 220, 160, 190, 220, 190} + ,{ 130, 70, 100, 130, 100} + ,{ 220, 160, 190, 220, 190} + } + ,{{ 310, 200, 240, 310, 240} + ,{ 270, 200, 240, 270, 240} + ,{ 310, 190, 220, 310, 220} + ,{ 270, 200, 240, 270, 240} + ,{ 300, 170, 210, 300, 210} + } + ,{{ 220, 160, 190, 220, 190} + ,{ 130, 70, 100, 130, 100} + ,{ 220, 160, 190, 220, 190} + ,{ 210, 10, 50, 210, 50} + ,{ 220, 160, 190, 220, 190} + } + ,{{ 300, 200, 240, 300, 240} + ,{ 270, 200, 240, 270, 240} + ,{ 300, 170, 210, 300, 210} + ,{ 270, 200, 240, 270, 240} + ,{ 150, 140, 120, 150, 120} + } + } + ,{{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 240, 240, 240, 240, 240} + ,{ 210, 210, 210, 210, 210} + } + ,{{ 200, 200, 200, 200, 200} + ,{ 200, 200, 200, 200, 200} + ,{ 190, 190, 190, 190, 190} + ,{ 160, 100, 160, 100, 160} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 240, 240, 240, 240, 240} + ,{ 210, 210, 210, 210, 210} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 160, 100, 160, 100, 160} + ,{ 190, 190, 190, 190, 190} + ,{ 50, 50, 50, 50, 50} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 210, 210, 210, 210, 210} + ,{ 240, 240, 240, 240, 240} + ,{ 120, 120, 120, 120, 120} + } + } + ,{{{ 240, 150, 240, 180, 240} + ,{ 240, 100, 240, 110, 240} + ,{ 220, 150, 220, 90, 220} + ,{ 240, 100, 240, 180, 240} + ,{ 210, 130, 210, 120, 210} + } + ,{{ 200, 60, 200, 100, 200} + ,{ 200, 60, 200, 70, 200} + ,{ 190, 60, 190, 60, 190} + ,{ 100, -30, 100, 100, 100} + ,{ 190, 60, 190, 60, 190} + } + ,{{ 240, 150, 240, 110, 240} + ,{ 240, 100, 240, 110, 240} + ,{ 220, 150, 220, 90, 220} + ,{ 240, 100, 240, 110, 240} + ,{ 210, 130, 210, 80, 210} + } + ,{{ 190, 60, 190, 180, 190} + ,{ 100, -30, 100, 100, 100} + ,{ 190, 60, 190, 60, 190} + ,{ 180, 40, 50, 180, 50} + ,{ 190, 60, 190, 60, 190} + } + ,{{ 240, 130, 240, 120, 240} + ,{ 240, 100, 240, 110, 240} + ,{ 210, 130, 210, 80, 210} + ,{ 240, 100, 240, 110, 240} + ,{ 120, -10, 120, 120, 120} + } + } + ,{{{ 260, 240, 240, 240, 260} + ,{ 260, 240, 240, 240, 260} + ,{ 220, 220, 220, 220, 220} + ,{ 240, 240, 240, 240, 240} + ,{ 210, 210, 210, 210, 210} + } + ,{{ 260, 200, 200, 200, 260} + ,{ 260, 200, 200, 200, 260} + ,{ 190, 190, 190, 190, 190} + ,{ 160, 100, 160, 100, 100} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 240, 240, 240, 240, 240} + ,{ 210, 210, 210, 210, 210} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 160, 100, 160, 100, 100} + ,{ 190, 190, 190, 190, 190} + ,{ 180, 50, 50, 50, 180} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 210, 210, 210, 210, 210} + ,{ 240, 240, 240, 240, 240} + ,{ 120, 120, 120, 120, 120} + } + } + } + ,{{{{ 280, 210, 210, 280, 270} + ,{ 270, 210, 210, 240, 270} + ,{ 280, 190, 190, 280, 190} + ,{ 210, 180, 180, 210, 180} + ,{ 280, 190, 190, 280, 190} + } + ,{{ 270, 210, 210, 240, 270} + ,{ 270, 210, 210, 240, 270} + ,{ 220, 190, 190, 220, 190} + ,{ 70, 10, 70, 40, 70} + ,{ 220, 190, 190, 220, 190} + } + ,{{ 280, 190, 190, 280, 190} + ,{ 210, 180, 180, 210, 180} + ,{ 280, 190, 190, 280, 190} + ,{ 210, 180, 180, 210, 180} + ,{ 280, 190, 190, 280, 190} + } + ,{{ 220, 190, 190, 220, 190} + ,{ 130, 70, 130, 100, 130} + ,{ 220, 190, 190, 220, 190} + ,{ 210, 50, 50, 210, 180} + ,{ 220, 190, 190, 220, 190} + } + ,{{ 280, 190, 190, 280, 190} + ,{ 210, 180, 180, 210, 180} + ,{ 280, 190, 190, 280, 190} + ,{ 210, 180, 180, 210, 180} + ,{ 140, 140, 110, 140, 110} + } + } + ,{{{ 280, 190, 210, 280, 210} + ,{ 240, 190, 210, 240, 210} + ,{ 280, 160, 190, 280, 190} + ,{ 210, 150, 180, 210, 180} + ,{ 280, 150, 190, 280, 190} + } + ,{{ 240, 190, 210, 240, 210} + ,{ 240, 190, 210, 240, 210} + ,{ 220, 150, 190, 220, 190} + ,{ 40, -20, 10, 40, 10} + ,{ 220, 150, 190, 220, 190} + } + ,{{ 280, 150, 190, 280, 190} + ,{ 210, 150, 180, 210, 180} + ,{ 280, 150, 190, 280, 190} + ,{ 210, 150, 180, 210, 180} + ,{ 280, 150, 190, 280, 190} + } + ,{{ 220, 150, 190, 220, 190} + ,{ 100, 40, 70, 100, 70} + ,{ 220, 150, 190, 220, 190} + ,{ 210, 10, 50, 210, 50} + ,{ 220, 150, 190, 220, 190} + } + 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190} + ,{ 180, 180, 180, 180, 180} + ,{ 190, 190, 190, 190, 190} + ,{ 180, 180, 180, 180, 180} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 130, 70, 130, 70, 70} + ,{ 190, 190, 190, 190, 190} + ,{ 180, 50, 50, 50, 180} + ,{ 190, 190, 190, 190, 190} + } + ,{{ 190, 190, 190, 190, 190} + ,{ 180, 180, 180, 180, 180} + ,{ 190, 190, 190, 190, 190} + ,{ 180, 180, 180, 180, 180} + ,{ 110, 110, 110, 110, 110} + } + } + } + ,{{{{ 400, 360, 340, 400, 400} + ,{ 400, 360, 340, 370, 400} + ,{ 400, 310, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 400, 330, 310, 400, 310} + } + ,{{ 400, 360, 340, 370, 400} + ,{ 400, 360, 340, 370, 400} + ,{ 340, 310, 310, 340, 310} + ,{ 290, 230, 290, 260, 290} + ,{ 340, 310, 310, 340, 310} + } + ,{{ 400, 310, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 400, 310, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 400, 310, 310, 400, 310} + } + ,{{ 360, 360, 330, 340, 330} + ,{ 360, 360, 330, 300, 330} + ,{ 340, 310, 310, 340, 310} + 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310, 310, 310, 310, 310} + } + ,{{ 330, 310, 330, 310, 310} + ,{ 330, 270, 330, 270, 270} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 180, 180, 180, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + } + } + ,{{{{ 370, 310, 370, 370, 370} + ,{ 370, 310, 370, 340, 370} + ,{ 370, 280, 280, 370, 280} + ,{ 310, 280, 280, 310, 280} + ,{ 370, 300, 280, 370, 280} + } + ,{{ 310, 280, 280, 310, 300} + ,{ 300, 240, 240, 270, 300} + ,{ 310, 280, 280, 310, 280} + ,{ 200, 140, 200, 170, 200} + ,{ 310, 280, 280, 310, 280} + } + ,{{ 370, 280, 280, 370, 280} + ,{ 310, 280, 280, 310, 280} + ,{ 370, 280, 280, 370, 280} + ,{ 310, 280, 280, 310, 280} + ,{ 370, 280, 280, 370, 280} + } + ,{{ 370, 310, 370, 340, 370} + ,{ 370, 310, 370, 340, 370} + ,{ 310, 280, 280, 310, 280} + ,{ 310, 150, 150, 310, 280} + ,{ 310, 280, 280, 310, 280} + } + ,{{ 370, 300, 280, 370, 280} 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280, 280, 280, 280, 280} + ,{ 280, 150, 150, 150, 280} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + } + } + } + ,{{{{ 350, 280, 280, 350, 340} + ,{ 340, 280, 280, 310, 340} + ,{ 350, 260, 260, 350, 260} + ,{ 290, 260, 260, 290, 260} + ,{ 350, 260, 260, 350, 260} + } + ,{{ 340, 280, 280, 310, 340} + ,{ 340, 280, 280, 310, 340} + ,{ 280, 250, 250, 280, 250} + ,{ 210, 150, 210, 180, 210} + ,{ 280, 250, 250, 280, 250} + } + ,{{ 350, 260, 260, 350, 260} + ,{ 290, 260, 260, 290, 260} + ,{ 350, 260, 260, 350, 260} + ,{ 290, 260, 260, 290, 260} + ,{ 350, 260, 260, 350, 260} + } + ,{{ 280, 250, 280, 280, 280} + ,{ 280, 220, 280, 250, 280} + ,{ 280, 250, 250, 280, 250} + ,{ 260, 100, 100, 260, 230} + ,{ 280, 250, 250, 280, 250} + } + ,{{ 350, 260, 260, 350, 260} + ,{ 290, 260, 260, 290, 260} + ,{ 350, 260, 260, 350, 260} + ,{ 290, 260, 260, 290, 260} + ,{ 200, 190, 170, 200, 170} + } + } + ,{{{ 350, 240, 280, 350, 280} + ,{ 310, 240, 280, 310, 280} + ,{ 350, 220, 260, 350, 260} + ,{ 290, 230, 260, 290, 260} + ,{ 350, 220, 260, 350, 260} + } + ,{{ 310, 240, 280, 310, 280} + ,{ 310, 240, 280, 310, 280} + ,{ 280, 220, 250, 280, 250} + ,{ 180, 120, 150, 180, 150} + ,{ 280, 220, 250, 280, 250} + } + ,{{ 350, 230, 260, 350, 260} + ,{ 290, 230, 260, 290, 260} + ,{ 350, 220, 260, 350, 260} + ,{ 290, 230, 260, 290, 260} + ,{ 350, 220, 260, 350, 260} + } + ,{{ 280, 220, 250, 280, 250} + ,{ 250, 190, 220, 250, 220} + ,{ 280, 220, 250, 280, 250} + ,{ 260, 70, 100, 260, 100} + ,{ 280, 220, 250, 280, 250} + } + ,{{ 350, 230, 260, 350, 260} + ,{ 290, 230, 260, 290, 260} + ,{ 350, 220, 260, 350, 260} + ,{ 290, 230, 260, 290, 260} + ,{ 200, 190, 170, 200, 170} + } + } + ,{{{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 280, 280, 280, 280, 280} + 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260, 130, 260, 130, 260} + ,{ 260, 180, 260, 130, 260} + } + ,{{ 250, 120, 250, 230, 250} + ,{ 220, 90, 220, 220, 220} + ,{ 250, 120, 250, 120, 250} + ,{ 230, 100, 100, 230, 100} + ,{ 250, 120, 250, 120, 250} + } + ,{{ 260, 180, 260, 170, 260} + ,{ 260, 130, 260, 130, 260} + ,{ 260, 180, 260, 130, 260} + ,{ 260, 130, 260, 130, 260} + ,{ 170, 30, 170, 170, 170} + } + } + ,{{{ 340, 280, 280, 280, 340} + ,{ 340, 280, 280, 280, 340} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 340, 280, 280, 280, 340} + ,{ 340, 280, 280, 280, 340} + ,{ 250, 250, 250, 250, 250} + ,{ 210, 150, 210, 150, 150} + ,{ 250, 250, 250, 250, 250} + } + ,{{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 280, 250, 280, 250, 250} + ,{ 280, 220, 280, 220, 220} + ,{ 250, 250, 250, 250, 250} + ,{ 230, 100, 100, 100, 230} + ,{ 250, 250, 250, 250, 250} + } + ,{{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 260, 260, 260, 260} + ,{ 170, 170, 170, 170, 170} + } + } + } + ,{{{{ 370, 280, 280, 370, 340} + ,{ 340, 280, 280, 310, 340} + ,{ 370, 280, 280, 370, 280} + ,{ 310, 280, 280, 310, 280} + ,{ 370, 280, 280, 370, 280} + } + ,{{ 340, 280, 280, 310, 340} + ,{ 340, 280, 280, 310, 340} + ,{ 260, 230, 230, 260, 230} + ,{ 230, 170, 230, 200, 230} + ,{ 260, 230, 230, 260, 230} + } + ,{{ 370, 280, 280, 370, 280} + ,{ 310, 280, 280, 310, 280} + ,{ 370, 280, 280, 370, 280} + ,{ 310, 280, 280, 310, 280} + ,{ 370, 280, 280, 370, 280} + } + ,{{ 280, 230, 240, 280, 250} + ,{ 240, 180, 240, 210, 240} + ,{ 260, 230, 230, 260, 230} + ,{ 280, 120, 120, 280, 250} + ,{ 260, 230, 230, 260, 230} + } + ,{{ 340, 280, 280, 340, 280} + ,{ 310, 280, 280, 310, 280} + ,{ 340, 250, 250, 340, 250} + ,{ 310, 280, 280, 310, 280} + ,{ 220, 220, 190, 220, 190} + } + } + ,{{{ 370, 240, 280, 370, 280} + ,{ 310, 240, 280, 310, 280} 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230, 230, 230, 230, 230} + } + ,{{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 240, 230, 240, 230, 240} + ,{ 240, 180, 240, 180, 240} + ,{ 230, 230, 230, 230, 230} + ,{ 120, 120, 120, 120, 120} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 250, 250, 250, 250, 250} + ,{ 280, 280, 280, 280, 280} + ,{ 190, 190, 190, 190, 190} + } + } + ,{{{ 280, 200, 280, 250, 280} + ,{ 280, 140, 280, 180, 280} + ,{ 280, 200, 280, 150, 280} + ,{ 280, 140, 280, 250, 280} + ,{ 280, 200, 280, 190, 280} + } + ,{{ 280, 140, 280, 170, 280} + ,{ 280, 140, 280, 150, 280} + ,{ 230, 100, 230, 100, 230} + ,{ 170, 40, 170, 170, 170} + ,{ 230, 100, 230, 100, 230} + } + ,{{ 280, 200, 280, 150, 280} + ,{ 280, 140, 280, 150, 280} + ,{ 280, 200, 280, 150, 280} + ,{ 280, 140, 280, 150, 280} + ,{ 280, 200, 280, 150, 280} + } + ,{{ 250, 120, 230, 250, 230} + ,{ 180, 50, 180, 180, 180} + ,{ 230, 100, 230, 100, 230} + ,{ 250, 120, 120, 250, 120} + ,{ 230, 100, 230, 100, 230} + } + ,{{ 280, 170, 280, 190, 280} + ,{ 280, 140, 280, 150, 280} + ,{ 250, 170, 250, 120, 250} + ,{ 280, 140, 280, 150, 280} + ,{ 190, 60, 190, 190, 190} + } + } + ,{{{ 340, 280, 280, 280, 340} + ,{ 340, 280, 280, 280, 340} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 340, 280, 280, 280, 340} + ,{ 340, 280, 280, 280, 340} + ,{ 230, 230, 230, 230, 230} + ,{ 230, 170, 230, 170, 170} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 250, 230, 240, 230, 250} + ,{ 240, 180, 240, 180, 180} + ,{ 230, 230, 230, 230, 230} + ,{ 250, 120, 120, 120, 250} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 280, 280, 280, 280, 280} + ,{ 280, 280, 280, 280, 280} + ,{ 250, 250, 250, 250, 250} + ,{ 280, 280, 280, 280, 280} + ,{ 190, 190, 190, 190, 190} + } + } + } + ,{{{{ 400, 360, 370, 400, 400} + ,{ 400, 360, 370, 370, 400} + ,{ 400, 310, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 400, 330, 310, 400, 310} + } + ,{{ 400, 360, 340, 370, 400} + ,{ 400, 360, 340, 370, 400} + ,{ 340, 310, 310, 340, 310} + ,{ 290, 230, 290, 260, 290} + ,{ 340, 310, 310, 340, 310} + } + ,{{ 400, 310, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 400, 310, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 400, 310, 310, 400, 310} + } + ,{{ 370, 360, 370, 340, 370} + ,{ 370, 360, 370, 340, 370} + ,{ 340, 310, 310, 340, 310} + ,{ 340, 180, 180, 340, 310} + ,{ 340, 310, 310, 340, 310} + } + ,{{ 400, 330, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 400, 310, 310, 400, 310} + ,{ 340, 310, 310, 340, 310} + ,{ 340, 330, 310, 340, 310} + } + } + ,{{{ 400, 360, 340, 400, 340} + ,{ 370, 360, 340, 370, 340} + ,{ 400, 270, 310, 400, 310} + ,{ 340, 270, 310, 340, 310} + ,{ 400, 330, 310, 400, 310} + } + 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INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 240, 240, 220, 230, 220} + ,{ 240, 240, 220, 210, 220} + ,{ 230, 220, 210, 230, 210} + ,{ 240, 240, 220, 210, 220} + ,{ 210, 210, 190, 210, 190} + } + ,{{ 200, 200, 180, 170, 180} + ,{ 200, 200, 180, 170, 180} + ,{ 190, 190, 180, 170, 180} + ,{ 140, 100, 140, 80, 140} + ,{ 190, 190, 180, 170, 180} + } + ,{{ 240, 240, 220, 230, 220} + ,{ 240, 240, 220, 210, 220} + ,{ 230, 220, 210, 230, 210} + ,{ 240, 240, 220, 210, 220} + ,{ 210, 210, 190, 210, 190} + } + ,{{ 190, 190, 180, 170, 180} + ,{ 140, 100, 140, 80, 140} + ,{ 190, 190, 180, 170, 180} + ,{ 130, 50, 30, 130, 70} + ,{ 190, 190, 180, 170, 180} + } + ,{{ 240, 240, 220, 210, 220} + ,{ 240, 240, 220, 210, 220} + ,{ 210, 210, 190, 210, 190} + ,{ 240, 240, 220, 210, 220} + ,{ 180, 180, 100, 90, 100} + } + } + ,{{{ 240, 240, 220, 230, 220} + ,{ 240, 240, 220, 180, 220} + ,{ 230, 220, 210, 230, 210} + ,{ 240, 240, 220, 180, 220} + ,{ 210, 210, 190, 210, 190} + } + ,{{ 200, 200, 180, 140, 180} + ,{ 200, 200, 180, 140, 180} + ,{ 190, 190, 180, 140, 180} + ,{ 100, 100, 90, 50, 90} + ,{ 190, 190, 180, 140, 180} + } + ,{{ 240, 240, 220, 230, 220} + ,{ 240, 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,{ 170, 170, 170, 170, 170} + } + ,{{ 220, 210, 220, 210, 220} + ,{ 220, 210, 220, 210, 220} + ,{ 190, 180, 190, 180, 190} + ,{ 220, 210, 220, 210, 220} + ,{ 100, 90, 100, 90, 100} + } + } + ,{{{ 220, 160, 220, 130, 220} + ,{ 220, 110, 220, 60, 220} + ,{ 210, 160, 210, 50, 210} + ,{ 220, 110, 220, 130, 220} + ,{ 190, 140, 190, 70, 190} + } + ,{{ 180, 70, 180, 60, 180} + ,{ 180, 70, 180, 20, 180} + ,{ 180, 70, 180, 20, 180} + ,{ 90, -20, 90, 60, 90} + ,{ 180, 70, 180, 20, 180} + } + ,{{ 220, 160, 220, 60, 220} + ,{ 220, 110, 220, 60, 220} + ,{ 210, 160, 210, 50, 210} + ,{ 220, 110, 220, 60, 220} + ,{ 190, 140, 190, 30, 190} + } + ,{{ 180, 70, 180, 130, 180} + ,{ 90, -20, 90, 60, 90} + ,{ 180, 70, 180, 20, 180} + ,{ 130, 50, 30, 130, 30} + ,{ 180, 70, 180, 20, 180} + } + ,{{ 220, 140, 220, 70, 220} + ,{ 220, 110, 220, 60, 220} + ,{ 190, 140, 190, 30, 190} + ,{ 220, 110, 220, 60, 220} + ,{ 100, 0, 100, 70, 100} + } + } + ,{{{ 220, 210, 220, 210, 150} + ,{ 220, 210, 220, 210, 150} + ,{ 200, 200, 200, 200, 110} + ,{ 220, 210, 220, 210, 130} + ,{ 190, 180, 190, 180, 100} + } + ,{{ 180, 170, 180, 170, 150} + ,{ 180, 170, 180, 170, 150} + ,{ 170, 170, 170, 170, 80} + ,{ 140, 80, 140, 80, 0} + ,{ 170, 170, 170, 170, 80} + } + ,{{ 220, 210, 220, 210, 130} + ,{ 220, 210, 220, 210, 130} + ,{ 200, 200, 200, 200, 110} + ,{ 220, 210, 220, 210, 130} + ,{ 190, 180, 190, 180, 100} + } + ,{{ 170, 170, 170, 170, 80} + ,{ 140, 80, 140, 80, 0} + ,{ 170, 170, 170, 170, 80} + ,{ 70, 20, 30, 20, 70} + ,{ 170, 170, 170, 170, 80} + } + ,{{ 220, 210, 220, 210, 130} + ,{ 220, 210, 220, 210, 130} + ,{ 190, 180, 190, 180, 100} + ,{ 220, 210, 220, 210, 130} + ,{ 100, 90, 100, 90, 10} + } + } + } + ,{{{{ 210, 210, 200, 200, 200} + ,{ 210, 210, 200, 190, 200} + ,{ 200, 190, 180, 200, 180} + ,{ 180, 180, 170, 160, 170} + ,{ 190, 190, 170, 190, 170} + } + ,{{ 210, 210, 200, 190, 200} + ,{ 210, 210, 200, 190, 200} + ,{ 190, 190, 170, 160, 170} + ,{ 50, 10, 50, -10, 50} + ,{ 190, 190, 170, 160, 170} 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,{{{ 200, 130, 200, 130, 200} + ,{ 200, 90, 200, 40, 200} + ,{ 180, 130, 180, 20, 180} + ,{ 170, 60, 170, 130, 170} + ,{ 170, 120, 170, 70, 170} + } + ,{{ 200, 90, 200, 40, 200} + ,{ 200, 90, 200, 40, 200} + ,{ 170, 60, 170, 10, 170} + ,{ 0, -110, 0, -30, 0} + ,{ 170, 60, 170, 10, 170} + } + ,{{ 170, 120, 170, 10, 170} + ,{ 170, 60, 170, 10, 170} + ,{ 170, 120, 170, 10, 170} + ,{ 170, 60, 170, 10, 170} + ,{ 170, 120, 170, 10, 170} + } + ,{{ 170, 60, 170, 130, 170} + ,{ 60, -50, 60, 30, 60} + ,{ 170, 60, 170, 10, 170} + ,{ 130, 50, 30, 130, 30} + ,{ 170, 60, 170, 10, 170} + } + ,{{ 180, 130, 180, 70, 180} + ,{ 170, 60, 170, 10, 170} + ,{ 180, 130, 180, 20, 180} + ,{ 170, 60, 170, 10, 170} + ,{ 100, -10, 100, 70, 100} + } + } + ,{{{ 190, 190, 190, 190, 160} + ,{ 190, 190, 190, 190, 160} + ,{ 170, 170, 170, 170, 80} + ,{ 160, 160, 160, 160, 70} + ,{ 170, 160, 170, 160, 80} + } + ,{{ 190, 190, 190, 190, 160} + ,{ 190, 190, 190, 190, 160} + ,{ 170, 160, 170, 160, 80} + ,{ 50, -10, 50, -10, -100} + ,{ 170, 160, 170, 160, 80} + } + ,{{ 170, 160, 170, 160, 80} + ,{ 160, 160, 160, 160, 70} + ,{ 170, 160, 170, 160, 80} + ,{ 160, 160, 160, 160, 70} + ,{ 170, 160, 170, 160, 80} + } + ,{{ 170, 160, 170, 160, 80} + ,{ 110, 50, 110, 50, -30} + ,{ 170, 160, 170, 160, 80} + ,{ 70, 20, 30, 20, 70} + ,{ 170, 160, 170, 160, 80} + } + ,{{ 170, 170, 170, 170, 80} + ,{ 160, 160, 160, 160, 70} + ,{ 170, 170, 170, 170, 80} + ,{ 160, 160, 160, 160, 70} + ,{ 90, 90, 90, 90, 0} + } + } + } + ,{{{{ 370, 370, 330, 320, 330} + ,{ 340, 340, 330, 320, 330} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 370, 370, 290, 310, 290} + } + ,{{ 340, 340, 330, 320, 330} + ,{ 340, 340, 330, 320, 330} + ,{ 310, 310, 290, 280, 290} + ,{ 270, 230, 270, 200, 270} + ,{ 310, 310, 290, 280, 290} + } + ,{{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 310, 310, 290, 310, 290} + } + ,{{ 310, 310, 310, 280, 310} + ,{ 310, 270, 310, 240, 310} + ,{ 310, 310, 290, 280, 290} + ,{ 260, 180, 160, 260, 200} + ,{ 310, 310, 290, 280, 290} + } + ,{{ 370, 370, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 370, 370, 290, 280, 290} + } + } + ,{{{ 370, 370, 330, 310, 330} + ,{ 340, 340, 330, 290, 330} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 370, 370, 290, 310, 290} + } + ,{{ 340, 340, 330, 290, 330} + ,{ 340, 340, 330, 290, 330} + ,{ 310, 310, 290, 250, 290} + ,{ 230, 230, 210, 170, 210} + ,{ 310, 310, 290, 250, 290} + } + ,{{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 310, 310, 290, 310, 290} + } + ,{{ 310, 310, 290, 250, 290} + ,{ 270, 270, 250, 210, 250} + ,{ 310, 310, 290, 250, 290} + ,{ 250, 180, 160, 250, 160} + ,{ 310, 310, 290, 250, 290} + } + ,{{ 370, 370, 290, 310, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 370, 370, 290, 250, 290} + } + } + ,{{{ 320, 320, 320, 320, 320} + ,{ 320, 320, 320, 320, 320} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + } + ,{{ 320, 320, 320, 320, 320} + ,{ 320, 320, 320, 320, 320} + ,{ 290, 280, 290, 280, 290} + ,{ 270, 200, 270, 200, 270} + ,{ 290, 280, 290, 280, 290} + } + ,{{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + } + ,{{ 310, 280, 310, 280, 310} + ,{ 310, 240, 310, 240, 310} + ,{ 290, 280, 290, 280, 290} + ,{ 160, 150, 160, 150, 160} + ,{ 290, 280, 290, 280, 290} + } + ,{{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + ,{ 290, 280, 290, 280, 290} + } + } + ,{{{ 330, 240, 330, 260, 330} + ,{ 330, 220, 330, 220, 330} + ,{ 290, 240, 290, 130, 290} + ,{ 290, 180, 290, 260, 290} + ,{ 290, 240, 290, 260, 290} + } + ,{{ 330, 220, 330, 180, 330} + ,{ 330, 220, 330, 170, 330} + ,{ 290, 180, 290, 130, 290} + ,{ 210, 100, 210, 180, 210} + ,{ 290, 180, 290, 130, 290} + } + ,{{ 290, 240, 290, 130, 290} + ,{ 290, 180, 290, 130, 290} + ,{ 290, 240, 290, 130, 290} + ,{ 290, 180, 290, 130, 290} + ,{ 290, 240, 290, 130, 290} + } + ,{{ 290, 180, 290, 260, 290} + ,{ 250, 140, 250, 220, 250} + ,{ 290, 180, 290, 130, 290} + ,{ 260, 180, 160, 260, 160} + ,{ 290, 180, 290, 130, 290} + } + ,{{ 290, 240, 290, 260, 290} + ,{ 290, 180, 290, 130, 290} + ,{ 290, 240, 290, 130, 290} + ,{ 290, 180, 290, 130, 290} + ,{ 290, 180, 290, 260, 290} + } + } + ,{{{ 320, 320, 320, 320, 290} + ,{ 320, 320, 320, 320, 290} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + } + ,{{ 320, 320, 320, 320, 290} + ,{ 320, 320, 320, 320, 290} + ,{ 290, 280, 290, 280, 200} + ,{ 270, 200, 270, 200, 120} + ,{ 290, 280, 290, 280, 200} + } + ,{{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + } + ,{{ 310, 280, 310, 280, 200} + ,{ 310, 240, 310, 240, 160} + ,{ 290, 280, 290, 280, 200} + ,{ 200, 150, 160, 150, 200} + ,{ 290, 280, 290, 280, 200} + } + ,{{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + ,{ 290, 280, 290, 280, 200} + } + } + } + ,{{{{ 350, 340, 350, 280, 350} + ,{ 350, 310, 350, 280, 350} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 340, 340, 260, 280, 260} + } + ,{{ 280, 280, 260, 250, 260} + ,{ 240, 240, 230, 220, 230} + ,{ 280, 280, 260, 250, 260} + ,{ 180, 140, 180, 120, 180} + ,{ 280, 280, 260, 250, 260} + } + ,{{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 280, 260} + } + ,{{ 350, 310, 350, 280, 350} + ,{ 350, 310, 350, 280, 350} + ,{ 280, 280, 260, 250, 260} + ,{ 230, 150, 130, 230, 170} + ,{ 280, 280, 260, 250, 260} + } + ,{{ 340, 340, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 340, 340, 260, 250, 260} + } + } + ,{{{ 340, 340, 290, 280, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 340, 340, 260, 280, 260} + } + ,{{ 280, 280, 260, 220, 260} + ,{ 240, 240, 230, 190, 230} + ,{ 280, 280, 260, 220, 260} + ,{ 140, 140, 130, 90, 130} + ,{ 280, 280, 260, 220, 260} + } + ,{{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 280, 260} + } + ,{{ 310, 310, 290, 250, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 280, 280, 260, 220, 260} + ,{ 220, 150, 130, 220, 130} + ,{ 280, 280, 260, 220, 260} + } + ,{{ 340, 340, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 340, 340, 260, 220, 260} + } + } + ,{{{ 350, 280, 350, 280, 350} + ,{ 350, 280, 350, 280, 350} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + } + ,{{ 260, 250, 260, 250, 260} + ,{ 220, 220, 220, 220, 220} + ,{ 260, 250, 260, 250, 260} + ,{ 180, 120, 180, 120, 180} + ,{ 260, 250, 260, 250, 260} + } + ,{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + } + ,{{ 350, 280, 350, 280, 350} + ,{ 350, 280, 350, 280, 350} + ,{ 260, 250, 260, 250, 260} + ,{ 130, 120, 130, 120, 130} + ,{ 260, 250, 260, 250, 260} + } + ,{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + } + } + ,{{{ 290, 210, 290, 260, 290} + ,{ 290, 180, 290, 260, 290} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 150, 260, 230, 260} + ,{ 260, 210, 260, 230, 260} + } + ,{{ 260, 150, 260, 100, 260} + ,{ 230, 120, 230, 70, 230} + ,{ 260, 150, 260, 100, 260} + ,{ 130, 20, 130, 100, 130} + ,{ 260, 150, 260, 100, 260} + } + ,{{ 260, 210, 260, 100, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 260, 210, 260, 100, 260} + } + ,{{ 290, 180, 290, 260, 290} + ,{ 290, 180, 290, 260, 290} + ,{ 260, 150, 260, 100, 260} + ,{ 230, 150, 130, 230, 130} + ,{ 260, 150, 260, 100, 260} + } + ,{{ 260, 210, 260, 230, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 260, 150, 260, 230, 260} + } + } + ,{{{ 350, 280, 350, 280, 200} + ,{ 350, 280, 350, 280, 200} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + } + ,{{ 260, 250, 260, 250, 190} + ,{ 220, 220, 220, 220, 190} + ,{ 260, 250, 260, 250, 170} + ,{ 180, 120, 180, 120, 30} + ,{ 260, 250, 260, 250, 170} + } + ,{{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + } + ,{{ 350, 280, 350, 280, 200} + ,{ 350, 280, 350, 280, 200} + ,{ 260, 250, 260, 250, 170} + ,{ 170, 120, 130, 120, 170} + ,{ 260, 250, 260, 250, 170} + } + ,{{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + ,{ 260, 250, 260, 250, 170} + } + } + } + ,{{{{ 280, 280, 260, 260, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 260, 260, 240, 260, 240} + ,{ 260, 260, 250, 240, 250} + ,{ 260, 260, 240, 260, 240} + } + ,{{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 250, 250, 240, 230, 240} + ,{ 190, 150, 190, 130, 190} + ,{ 250, 250, 240, 230, 240} + } + ,{{ 260, 260, 250, 260, 250} + ,{ 260, 260, 250, 240, 250} + ,{ 260, 260, 240, 260, 240} + ,{ 260, 260, 250, 240, 250} + ,{ 260, 260, 240, 260, 240} + } + ,{{ 260, 250, 260, 230, 260} + ,{ 260, 220, 260, 200, 260} + ,{ 250, 250, 240, 230, 240} + ,{ 190, 110, 90, 190, 120} + ,{ 250, 250, 240, 230, 240} + } + ,{{ 260, 260, 250, 260, 250} + ,{ 260, 260, 250, 240, 250} + ,{ 260, 260, 240, 260, 240} + ,{ 260, 260, 250, 240, 250} + ,{ 230, 230, 150, 140, 150} + } + } + ,{{{ 280, 280, 260, 260, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 260, 260, 240, 260, 240} + ,{ 260, 260, 250, 210, 250} + ,{ 260, 260, 240, 260, 240} + } + ,{{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 250, 250, 240, 200, 240} + ,{ 150, 150, 140, 100, 140} + ,{ 250, 250, 240, 200, 240} + } + ,{{ 260, 260, 250, 260, 250} + ,{ 260, 260, 250, 210, 250} + ,{ 260, 260, 240, 260, 240} + ,{ 260, 260, 250, 210, 250} + ,{ 260, 260, 240, 260, 240} + } + ,{{ 250, 250, 240, 200, 240} + ,{ 220, 220, 210, 170, 210} + ,{ 250, 250, 240, 200, 240} + ,{ 180, 100, 90, 180, 90} + ,{ 250, 250, 240, 200, 240} + } + ,{{ 260, 260, 250, 260, 250} + ,{ 260, 260, 250, 210, 250} + ,{ 260, 260, 240, 260, 240} + ,{ 260, 260, 250, 210, 250} + ,{ 230, 230, 150, 110, 150} + } + } + ,{{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 240, 230, 240, 230, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 240, 230, 240, 230, 240} + } + ,{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 230, 230, 230, 230, 230} + ,{ 190, 130, 190, 130, 190} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 240, 230, 240, 230, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 240, 230, 240, 230, 240} + } + ,{{ 260, 230, 260, 230, 260} + ,{ 260, 200, 260, 200, 260} + ,{ 230, 230, 230, 230, 230} + ,{ 80, 80, 80, 80, 80} + ,{ 230, 230, 230, 230, 230} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 240, 230, 240, 230, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 150, 140, 150, 140, 150} + } + } + ,{{{ 260, 190, 260, 190, 260} + ,{ 260, 150, 260, 180, 260} + ,{ 240, 190, 240, 80, 240} + ,{ 250, 140, 250, 190, 250} + ,{ 240, 190, 240, 120, 240} + } + ,{{ 260, 150, 260, 110, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 240, 130, 240, 80, 240} + ,{ 140, 30, 140, 110, 140} + ,{ 240, 130, 240, 80, 240} + } + ,{{ 250, 190, 250, 90, 250} + ,{ 250, 140, 250, 90, 250} + ,{ 240, 190, 240, 80, 240} + ,{ 250, 140, 250, 90, 250} + ,{ 240, 190, 240, 80, 240} + } + ,{{ 240, 130, 240, 190, 240} + ,{ 210, 100, 210, 180, 210} + ,{ 240, 130, 240, 80, 240} + ,{ 190, 110, 90, 190, 90} + ,{ 240, 130, 240, 80, 240} + } + ,{{ 250, 190, 250, 120, 250} + ,{ 250, 140, 250, 90, 250} + ,{ 240, 190, 240, 80, 240} + ,{ 250, 140, 250, 90, 250} + ,{ 150, 40, 150, 120, 150} + } + } + ,{{{ 260, 250, 260, 250, 230} + ,{ 260, 250, 260, 250, 230} + ,{ 240, 230, 240, 230, 150} + ,{ 240, 240, 240, 240, 150} + ,{ 240, 230, 240, 230, 150} + } + ,{{ 260, 250, 260, 250, 230} + ,{ 260, 250, 260, 250, 230} + ,{ 230, 230, 230, 230, 140} + ,{ 190, 130, 190, 130, 40} + ,{ 230, 230, 230, 230, 140} + } + ,{{ 240, 240, 240, 240, 150} + ,{ 240, 240, 240, 240, 150} + ,{ 240, 230, 240, 230, 150} + ,{ 240, 240, 240, 240, 150} + ,{ 240, 230, 240, 230, 150} + } + ,{{ 260, 230, 260, 230, 140} + ,{ 260, 200, 260, 200, 110} + ,{ 230, 230, 230, 230, 140} + ,{ 120, 80, 80, 80, 120} + ,{ 230, 230, 230, 230, 140} + } + ,{{ 240, 240, 240, 240, 150} + ,{ 240, 240, 240, 240, 150} + ,{ 240, 230, 240, 230, 150} + ,{ 240, 240, 240, 240, 150} + ,{ 150, 140, 150, 140, 60} + } + } + } + ,{{{{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 280, 260} + } + ,{{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 230, 230, 220, 210, 220} + ,{ 210, 170, 210, 150, 210} + ,{ 230, 230, 220, 210, 220} + } + ,{{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 280, 260} + } + ,{{ 230, 230, 220, 210, 220} + ,{ 220, 180, 220, 160, 220} + ,{ 230, 230, 220, 210, 220} + ,{ 210, 130, 110, 210, 140} + ,{ 230, 230, 220, 210, 220} + } + ,{{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 250, 260} + ,{ 250, 250, 230, 250, 230} + ,{ 280, 280, 260, 250, 260} + ,{ 250, 250, 180, 170, 180} + } + } + ,{{{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 280, 260} + } + ,{{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 230, 230, 220, 180, 220} + ,{ 170, 170, 160, 120, 160} + ,{ 230, 230, 220, 180, 220} + } + ,{{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 280, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 280, 280, 260, 280, 260} + } + ,{{ 230, 230, 220, 200, 220} + ,{ 180, 180, 170, 130, 170} + ,{ 230, 230, 220, 180, 220} + ,{ 200, 120, 110, 200, 110} + ,{ 230, 230, 220, 180, 220} + } + ,{{ 280, 280, 260, 250, 260} + ,{ 280, 280, 260, 220, 260} + ,{ 250, 250, 230, 250, 230} + ,{ 280, 280, 260, 220, 260} + ,{ 250, 250, 180, 140, 180} + } + } + ,{{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + } + ,{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 210, 210, 210, 210, 210} + ,{ 210, 150, 210, 150, 210} + ,{ 210, 210, 210, 210, 210} + } + ,{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + } + ,{{ 220, 210, 220, 210, 220} + ,{ 220, 160, 220, 160, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 100, 100, 100, 100, 100} + ,{ 210, 210, 210, 210, 210} + } + ,{{ 260, 250, 260, 250, 260} + ,{ 260, 250, 260, 250, 260} + ,{ 230, 220, 230, 220, 230} + ,{ 260, 250, 260, 250, 260} + ,{ 170, 170, 170, 170, 170} + } + } + ,{{{ 260, 210, 260, 210, 260} + ,{ 260, 150, 260, 140, 260} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 150, 260, 210, 260} + ,{ 260, 210, 260, 150, 260} + } + ,{{ 260, 150, 260, 130, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 220, 110, 220, 60, 220} + ,{ 160, 50, 160, 130, 160} + ,{ 220, 110, 220, 60, 220} + } + ,{{ 260, 210, 260, 100, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 150, 260, 100, 260} + ,{ 260, 210, 260, 100, 260} + } + ,{{ 220, 130, 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140} + ,{ 260, 250, 260, 250, 170} + ,{ 170, 170, 170, 170, 80} + } + } + } + ,{{{{ 370, 370, 350, 320, 350} + ,{ 350, 340, 350, 320, 350} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 370, 370, 290, 310, 290} + } + ,{{ 340, 340, 330, 320, 330} + ,{ 340, 340, 330, 320, 330} + ,{ 310, 310, 290, 280, 290} + ,{ 270, 230, 270, 200, 270} + ,{ 310, 310, 290, 280, 290} + } + ,{{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 310, 310, 290, 310, 290} + } + ,{{ 350, 310, 350, 280, 350} + ,{ 350, 310, 350, 280, 350} + ,{ 310, 310, 290, 280, 290} + ,{ 260, 180, 160, 260, 200} + ,{ 310, 310, 290, 280, 290} + } + ,{{ 370, 370, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 280, 290} + ,{ 370, 370, 290, 280, 290} + } + } + ,{{{ 370, 370, 330, 310, 330} + ,{ 340, 340, 330, 290, 330} + ,{ 310, 310, 290, 310, 290} + ,{ 310, 310, 290, 250, 290} + ,{ 370, 370, 290, 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INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 240, 240, 240, 190, 240} + ,{ 240, 240, 240, 190, 240} + ,{ 220, 220, 220, 190, 220} + ,{ 240, 240, 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50, 0, 50, 0, 20} + ,{ 190, 150, 190, 150, 160} + } + ,{{ 240, 190, 240, 190, 210} + ,{ 240, 190, 240, 190, 210} + ,{ 210, 160, 210, 160, 180} + ,{ 240, 190, 240, 190, 210} + ,{ 120, 70, 120, 70, 90} + } + } + ,{{{ 240, 180, 240, 150, 240} + ,{ 240, 130, 240, 80, 240} + ,{ 220, 180, 220, 70, 220} + ,{ 240, 130, 240, 150, 240} + ,{ 210, 160, 210, 90, 210} + } + ,{{ 200, 90, 200, 80, 200} + ,{ 200, 90, 200, 40, 200} + ,{ 190, 90, 190, 40, 190} + ,{ 100, 0, 100, 80, 100} + ,{ 190, 90, 190, 40, 190} + } + ,{{ 240, 180, 240, 80, 240} + ,{ 240, 130, 240, 80, 240} + ,{ 220, 180, 220, 70, 220} + ,{ 240, 130, 240, 80, 240} + ,{ 210, 160, 210, 50, 210} + } + ,{{ 190, 90, 190, 150, 190} + ,{ 100, 0, 100, 80, 100} + ,{ 190, 90, 190, 40, 190} + ,{ 150, 70, 50, 150, 50} + ,{ 190, 90, 190, 40, 190} + } + ,{{ 240, 160, 240, 90, 240} + ,{ 240, 130, 240, 80, 240} + ,{ 210, 160, 210, 50, 210} + ,{ 240, 130, 240, 80, 240} + ,{ 120, 10, 120, 90, 120} + } + } + ,{{{ 240, 190, 240, 190, 170} + ,{ 240, 190, 240, 190, 170} + ,{ 220, 180, 220, 180, 140} + ,{ 240, 190, 240, 190, 150} + ,{ 210, 160, 210, 160, 120} + } + ,{{ 200, 150, 200, 150, 170} + ,{ 200, 150, 200, 150, 170} + ,{ 190, 150, 190, 150, 110} + ,{ 160, 60, 160, 60, 20} + ,{ 190, 150, 190, 150, 110} + } + ,{{ 240, 190, 240, 190, 150} + ,{ 240, 190, 240, 190, 150} + ,{ 220, 180, 220, 180, 140} + ,{ 240, 190, 240, 190, 150} + ,{ 210, 160, 210, 160, 120} + } + ,{{ 190, 150, 190, 150, 110} + ,{ 160, 60, 160, 60, 20} + ,{ 190, 150, 190, 150, 110} + ,{ 90, 0, 50, 0, 90} + ,{ 190, 150, 190, 150, 110} + } + ,{{ 240, 190, 240, 190, 150} + ,{ 240, 190, 240, 190, 150} + ,{ 210, 160, 210, 160, 120} + ,{ 240, 190, 240, 190, 150} + ,{ 120, 70, 120, 70, 30} + } + } + } + ,{{{{ 210, 210, 210, 170, 210} + ,{ 210, 210, 210, 170, 210} + ,{ 190, 190, 190, 160, 190} + ,{ 180, 180, 180, 150, 180} + ,{ 190, 190, 190, 150, 190} + } + ,{{ 210, 210, 210, 170, 210} + ,{ 210, 210, 210, 170, 210} + ,{ 190, 190, 190, 140, 190} + ,{ 70, 10, 70, -10, 40} + ,{ 190, 190, 190, 140, 190} + } + ,{{ 190, 190, 190, 150, 190} + ,{ 180, 180, 180, 140, 180} + ,{ 190, 190, 190, 150, 190} + ,{ 180, 180, 180, 140, 180} + ,{ 190, 190, 190, 150, 190} + } + ,{{ 190, 190, 190, 150, 190} + ,{ 130, 70, 130, 50, 100} + ,{ 190, 190, 190, 140, 190} + ,{ 150, 70, 50, 150, 90} + ,{ 190, 190, 190, 140, 190} + } + ,{{ 190, 190, 190, 160, 190} + ,{ 180, 180, 180, 140, 180} + ,{ 190, 190, 190, 160, 190} + ,{ 180, 180, 180, 140, 180} + ,{ 170, 170, 110, 90, 110} + } + } + ,{{{ 210, 210, 210, 160, 210} + ,{ 210, 210, 210, 120, 210} + ,{ 190, 190, 190, 160, 190} + ,{ 180, 180, 180, 90, 180} + ,{ 190, 190, 190, 150, 190} + } + ,{{ 210, 210, 210, 120, 210} + ,{ 210, 210, 210, 120, 210} + ,{ 190, 190, 190, 90, 190} + ,{ 10, 10, 10, -80, 10} + ,{ 190, 190, 190, 90, 190} + } + ,{{ 190, 190, 190, 150, 190} + ,{ 180, 180, 180, 90, 180} + ,{ 190, 190, 190, 150, 190} + ,{ 180, 180, 180, 90, 180} + ,{ 190, 190, 190, 150, 190} + } + ,{{ 190, 190, 190, 90, 190} + ,{ 70, 70, 70, -20, 70} + ,{ 190, 190, 190, 90, 190} + ,{ 80, 50, 50, 80, 50} + ,{ 190, 190, 190, 90, 190} + } + ,{{ 190, 190, 190, 160, 190} + ,{ 180, 180, 180, 90, 180} + ,{ 190, 190, 190, 160, 190} + ,{ 180, 180, 180, 90, 180} + ,{ 170, 170, 110, 20, 110} + } + } + ,{{{ 210, 170, 210, 170, 180} + ,{ 210, 170, 210, 170, 180} + ,{ 190, 150, 190, 150, 160} + ,{ 180, 140, 180, 140, 150} + ,{ 190, 140, 190, 140, 160} + } + ,{{ 210, 170, 210, 170, 180} + ,{ 210, 170, 210, 170, 180} + ,{ 190, 140, 190, 140, 160} + ,{ 70, -30, 70, -30, 40} + ,{ 190, 140, 190, 140, 160} + } + ,{{ 190, 140, 190, 140, 160} + ,{ 180, 140, 180, 140, 150} + ,{ 190, 140, 190, 140, 160} + ,{ 180, 140, 180, 140, 150} + ,{ 190, 140, 190, 140, 160} + } + ,{{ 190, 140, 190, 140, 160} + ,{ 130, 30, 130, 30, 100} + ,{ 190, 140, 190, 140, 160} + ,{ 50, 0, 50, 0, 20} + ,{ 190, 140, 190, 140, 160} + } + ,{{ 190, 150, 190, 150, 160} + ,{ 180, 140, 180, 140, 150} + ,{ 190, 150, 190, 150, 160} + ,{ 180, 140, 180, 140, 150} + ,{ 110, 70, 110, 70, 80} + } + } + ,{{{ 210, 150, 210, 150, 210} + ,{ 210, 110, 210, 60, 210} + ,{ 190, 150, 190, 40, 190} + ,{ 180, 80, 180, 150, 180} + ,{ 190, 140, 190, 90, 190} + } + ,{{ 210, 110, 210, 60, 210} + ,{ 210, 110, 210, 60, 210} + ,{ 190, 80, 190, 30, 190} + ,{ 10, -90, 10, -10, 10} + ,{ 190, 80, 190, 30, 190} + } + ,{{ 190, 140, 190, 30, 190} + ,{ 180, 80, 180, 30, 180} + ,{ 190, 140, 190, 30, 190} + ,{ 180, 80, 180, 30, 180} + ,{ 190, 140, 190, 30, 190} + } + ,{{ 190, 80, 190, 150, 190} + ,{ 70, -30, 70, 50, 70} + ,{ 190, 80, 190, 30, 190} + ,{ 150, 70, 50, 150, 50} + ,{ 190, 80, 190, 30, 190} + } + ,{{ 190, 150, 190, 90, 190} + ,{ 180, 80, 180, 30, 180} + ,{ 190, 150, 190, 40, 190} + ,{ 180, 80, 180, 30, 180} + ,{ 110, 10, 110, 90, 110} + } + } + ,{{{ 210, 170, 210, 170, 190} + ,{ 210, 170, 210, 170, 190} + ,{ 190, 150, 190, 150, 110} + ,{ 180, 140, 180, 140, 100} + ,{ 190, 140, 190, 140, 100} + } + ,{{ 210, 170, 210, 170, 190} + ,{ 210, 170, 210, 170, 190} + ,{ 190, 140, 190, 140, 100} + 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310, 330, 280, 310} + ,{ 330, 270, 330, 240, 300} + ,{ 310, 310, 310, 260, 310} + ,{ 280, 200, 180, 280, 220} + ,{ 310, 310, 310, 260, 310} + } + ,{{ 370, 370, 310, 280, 310} + ,{ 310, 310, 310, 260, 310} + ,{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 260, 310} + ,{ 370, 370, 310, 280, 310} + } + } + ,{{{ 370, 370, 340, 270, 340} + ,{ 340, 340, 340, 250, 340} + ,{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 370, 370, 310, 270, 310} + } + ,{{ 340, 340, 340, 250, 340} + ,{ 340, 340, 340, 250, 340} + ,{ 310, 310, 310, 210, 310} + ,{ 230, 230, 230, 130, 230} + ,{ 310, 310, 310, 210, 310} + } + ,{{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 270, 310} + } + ,{{ 310, 310, 310, 210, 310} + ,{ 270, 270, 270, 170, 270} + ,{ 310, 310, 310, 210, 310} + ,{ 210, 180, 180, 210, 180} + ,{ 310, 310, 310, 210, 310} + } + ,{{ 370, 370, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 370, 370, 310, 210, 310} + } + } + ,{{{ 340, 300, 340, 300, 310} + ,{ 340, 300, 340, 300, 310} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 340, 300, 340, 300, 310} + ,{ 340, 300, 340, 300, 310} + ,{ 310, 260, 310, 260, 280} + ,{ 290, 180, 290, 180, 260} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 330, 260, 330, 260, 300} + ,{ 330, 220, 330, 220, 300} + ,{ 310, 260, 310, 260, 280} + ,{ 180, 130, 180, 130, 150} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + } + } + ,{{{ 340, 260, 340, 280, 340} + ,{ 340, 240, 340, 240, 340} + ,{ 310, 260, 310, 150, 310} + ,{ 310, 200, 310, 280, 310} + ,{ 310, 260, 310, 280, 310} + } + ,{{ 340, 240, 340, 200, 340} + ,{ 340, 240, 340, 190, 340} + ,{ 310, 200, 310, 150, 310} + ,{ 230, 120, 230, 200, 230} + ,{ 310, 200, 310, 150, 310} + } + ,{{ 310, 260, 310, 150, 310} + ,{ 310, 200, 310, 150, 310} + ,{ 310, 260, 310, 150, 310} + ,{ 310, 200, 310, 150, 310} + ,{ 310, 260, 310, 150, 310} + } + ,{{ 310, 200, 310, 280, 310} + ,{ 270, 160, 270, 240, 270} + ,{ 310, 200, 310, 150, 310} + ,{ 280, 200, 180, 280, 180} + ,{ 310, 200, 310, 150, 310} + } + ,{{ 310, 260, 310, 280, 310} + ,{ 310, 200, 310, 150, 310} + ,{ 310, 260, 310, 150, 310} + ,{ 310, 200, 310, 150, 310} + ,{ 310, 200, 310, 280, 310} + } + } + ,{{{ 340, 300, 340, 300, 320} + ,{ 340, 300, 340, 300, 320} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + } + ,{{ 340, 300, 340, 300, 320} + ,{ 340, 300, 340, 300, 320} + ,{ 310, 260, 310, 260, 220} + ,{ 290, 180, 290, 180, 140} + ,{ 310, 260, 310, 260, 220} + } + ,{{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + } + ,{{ 330, 260, 330, 260, 220} + ,{ 330, 220, 330, 220, 180} + ,{ 310, 260, 310, 260, 220} + ,{ 220, 130, 180, 130, 220} + ,{ 310, 260, 310, 260, 220} + } + ,{{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + ,{ 310, 260, 310, 260, 220} + } + } + } + ,{{{{ 370, 340, 370, 280, 340} + ,{ 370, 310, 370, 280, 340} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 250, 280} + ,{ 340, 340, 280, 250, 280} + } + ,{{ 280, 280, 280, 230, 280} + ,{ 240, 240, 240, 200, 240} + ,{ 280, 280, 280, 230, 280} + ,{ 200, 140, 200, 120, 170} + ,{ 280, 280, 280, 230, 280} + } + ,{{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 240, 280} + } + ,{{ 370, 310, 370, 280, 340} + ,{ 370, 310, 370, 280, 340} + ,{ 280, 280, 280, 230, 280} + ,{ 250, 170, 150, 250, 190} + ,{ 280, 280, 280, 230, 280} + } + ,{{ 340, 340, 280, 250, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 340, 340, 280, 250, 280} + } + } + ,{{{ 340, 340, 310, 240, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 340, 340, 280, 240, 280} + } + ,{{ 280, 280, 280, 180, 280} + ,{ 240, 240, 240, 150, 240} + ,{ 280, 280, 280, 180, 280} + ,{ 140, 140, 140, 50, 140} + ,{ 280, 280, 280, 180, 280} + } + ,{{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 240, 280} + } + ,{{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 280, 280, 280, 180, 280} + ,{ 180, 150, 150, 180, 150} + ,{ 280, 280, 280, 180, 280} + } + ,{{ 340, 340, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 340, 340, 280, 180, 280} + } + } + ,{{{ 370, 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280, 120, 280} + ,{ 140, 40, 140, 120, 140} + ,{ 280, 170, 280, 120, 280} + } + ,{{ 280, 230, 280, 120, 280} + ,{ 280, 170, 280, 120, 280} + ,{ 280, 230, 280, 120, 280} + ,{ 280, 170, 280, 120, 280} + ,{ 280, 230, 280, 120, 280} + } + ,{{ 310, 200, 310, 280, 310} + ,{ 310, 200, 310, 280, 310} + ,{ 280, 170, 280, 120, 280} + ,{ 250, 170, 150, 250, 150} + ,{ 280, 170, 280, 120, 280} + } + ,{{ 280, 230, 280, 250, 280} + ,{ 280, 170, 280, 120, 280} + ,{ 280, 230, 280, 120, 280} + ,{ 280, 170, 280, 120, 280} + ,{ 280, 170, 280, 250, 280} + } + } + ,{{{ 370, 260, 370, 260, 220} + ,{ 370, 260, 370, 260, 220} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + } + ,{{ 280, 230, 280, 230, 220} + ,{ 240, 200, 240, 200, 220} + ,{ 280, 230, 280, 230, 190} + ,{ 200, 100, 200, 100, 60} + ,{ 280, 230, 280, 230, 190} + } + ,{{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + } + ,{{ 370, 260, 370, 260, 220} + ,{ 370, 260, 370, 260, 220} + ,{ 280, 230, 280, 230, 190} + ,{ 190, 100, 150, 100, 190} + ,{ 280, 230, 280, 230, 190} + } + ,{{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + ,{ 280, 230, 280, 230, 190} + } + } + } + ,{{{{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + } + ,{{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 250, 250, 250, 210, 250} + ,{ 210, 150, 210, 130, 180} + ,{ 250, 250, 250, 210, 250} + } + ,{{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + } + ,{{ 280, 250, 280, 210, 250} + ,{ 280, 220, 280, 200, 250} + ,{ 250, 250, 250, 210, 250} + ,{ 210, 130, 100, 210, 150} + ,{ 250, 250, 250, 210, 250} + } + ,{{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 230, 230, 170, 140, 170} + } + } + ,{{{ 280, 280, 280, 220, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 170, 260} + ,{ 260, 260, 260, 220, 260} + } + ,{{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 250, 250, 250, 160, 250} + ,{ 150, 150, 150, 60, 150} + ,{ 250, 250, 250, 160, 250} + } + ,{{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 170, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 170, 260} + ,{ 260, 260, 260, 220, 260} + } + ,{{ 250, 250, 250, 160, 250} + ,{ 220, 220, 220, 130, 220} + ,{ 250, 250, 250, 160, 250} + ,{ 140, 100, 100, 140, 100} + ,{ 250, 250, 250, 160, 250} + } + ,{{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 170, 260} + ,{ 260, 260, 260, 220, 260} + ,{ 260, 260, 260, 170, 260} + ,{ 230, 230, 170, 70, 170} + } + } + ,{{{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + ,{ 260, 210, 260, 210, 230} + ,{ 260, 220, 260, 220, 230} + ,{ 260, 210, 260, 210, 230} + } + ,{{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + ,{ 250, 210, 250, 210, 220} + ,{ 210, 110, 210, 110, 180} + ,{ 250, 210, 250, 210, 220} + } + ,{{ 260, 220, 260, 220, 230} + ,{ 260, 220, 260, 220, 230} + ,{ 260, 210, 260, 210, 230} + ,{ 260, 220, 260, 220, 230} + ,{ 260, 210, 260, 210, 230} + } + ,{{ 280, 210, 280, 210, 250} + ,{ 280, 180, 280, 180, 250} + ,{ 250, 210, 250, 210, 220} + ,{ 100, 60, 100, 60, 70} + ,{ 250, 210, 250, 210, 220} + } + ,{{ 260, 220, 260, 220, 230} + ,{ 260, 220, 260, 220, 230} + ,{ 260, 210, 260, 210, 230} + ,{ 260, 220, 260, 220, 230} + ,{ 170, 120, 170, 120, 140} + } + } + ,{{{ 280, 210, 280, 210, 280} + ,{ 280, 170, 280, 200, 280} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 160, 260, 210, 260} + ,{ 260, 210, 260, 140, 260} + } + ,{{ 280, 170, 280, 130, 280} + ,{ 280, 170, 280, 120, 280} + ,{ 250, 150, 250, 100, 250} + ,{ 150, 50, 150, 130, 150} + ,{ 250, 150, 250, 100, 250} + } + ,{{ 260, 210, 260, 110, 260} + ,{ 260, 160, 260, 110, 260} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 160, 260, 110, 260} + ,{ 260, 210, 260, 100, 260} + } + ,{{ 250, 150, 250, 210, 250} + ,{ 220, 120, 220, 200, 220} + ,{ 250, 150, 250, 100, 250} + ,{ 210, 130, 100, 210, 100} + ,{ 250, 150, 250, 100, 250} + } + ,{{ 260, 210, 260, 140, 260} + ,{ 260, 160, 260, 110, 260} + ,{ 260, 210, 260, 100, 260} + ,{ 260, 160, 260, 110, 260} + ,{ 170, 60, 170, 140, 170} + } + } + ,{{{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + ,{ 260, 210, 260, 210, 170} + ,{ 260, 220, 260, 220, 180} + ,{ 260, 210, 260, 210, 170} + } + ,{{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + ,{ 250, 210, 250, 210, 170} + ,{ 210, 110, 210, 110, 70} + ,{ 250, 210, 250, 210, 170} + } + ,{{ 260, 220, 260, 220, 180} + ,{ 260, 220, 260, 220, 180} + ,{ 260, 210, 260, 210, 170} + ,{ 260, 220, 260, 220, 180} + ,{ 260, 210, 260, 210, 170} + } + ,{{ 280, 210, 280, 210, 170} + ,{ 280, 180, 280, 180, 140} + ,{ 250, 210, 250, 210, 170} + ,{ 150, 60, 100, 60, 150} + ,{ 250, 210, 250, 210, 170} + } + ,{{ 260, 220, 260, 220, 180} + ,{ 260, 220, 260, 220, 180} + ,{ 260, 210, 260, 210, 170} + ,{ 260, 220, 260, 220, 180} + ,{ 170, 120, 170, 120, 80} + } + } + } + ,{{{{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 240, 280} + } + ,{{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 230, 230, 230, 190, 230} + ,{ 230, 170, 230, 150, 200} + ,{ 230, 230, 230, 190, 230} + } + ,{{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 240, 280} + } + ,{{ 240, 230, 240, 230, 230} + ,{ 240, 180, 240, 160, 210} + ,{ 230, 230, 230, 190, 230} + ,{ 230, 150, 120, 230, 170} + ,{ 230, 230, 230, 190, 230} + } + ,{{ 280, 280, 280, 230, 280} + ,{ 280, 280, 280, 230, 280} + ,{ 250, 250, 250, 210, 250} + ,{ 280, 280, 280, 230, 280} + ,{ 250, 250, 190, 170, 190} + } + } + ,{{{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 240, 280} + } + ,{{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 230, 230, 230, 140, 230} + ,{ 170, 170, 170, 80, 170} + ,{ 230, 230, 230, 140, 230} + } + ,{{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 240, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 280, 280, 280, 240, 280} + } + ,{{ 230, 230, 230, 160, 230} + ,{ 180, 180, 180, 90, 180} + ,{ 230, 230, 230, 140, 230} + ,{ 160, 120, 120, 160, 120} + ,{ 230, 230, 230, 140, 230} + } + ,{{ 280, 280, 280, 210, 280} + ,{ 280, 280, 280, 180, 280} + ,{ 250, 250, 250, 210, 250} + ,{ 280, 280, 280, 180, 280} + ,{ 250, 250, 190, 100, 190} + } + } + ,{{{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 230, 250} + } + ,{{ 280, 230, 280, 230, 250} + ,{ 280, 230, 280, 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310, 310, 310, 210, 310} + ,{ 370, 370, 310, 270, 310} + } + ,{{ 340, 340, 340, 250, 340} + ,{ 340, 340, 340, 250, 340} + ,{ 310, 310, 310, 210, 310} + ,{ 230, 230, 230, 130, 230} + ,{ 310, 310, 310, 210, 310} + } + ,{{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 270, 310} + } + ,{{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 210, 180, 180, 210, 180} + ,{ 310, 310, 310, 210, 310} + } + ,{{ 370, 370, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 310, 310, 310, 270, 310} + ,{ 310, 310, 310, 210, 310} + ,{ 370, 370, 310, 210, 310} + } + } + ,{{{ 370, 300, 370, 300, 340} + ,{ 370, 300, 370, 300, 340} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 340, 300, 340, 300, 310} + ,{ 340, 300, 340, 300, 310} + ,{ 310, 260, 310, 260, 280} + ,{ 290, 180, 290, 180, 260} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 370, 260, 370, 260, 340} + ,{ 370, 260, 370, 260, 340} + ,{ 310, 260, 310, 260, 280} + ,{ 180, 130, 180, 130, 150} + ,{ 310, 260, 310, 260, 280} + } + ,{{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + ,{ 310, 260, 310, 260, 280} + } + } + ,{{{ 340, 260, 340, 280, 340} + ,{ 340, 240, 340, 280, 340} + ,{ 310, 260, 310, 150, 310} + ,{ 310, 200, 310, 280, 310} + ,{ 310, 260, 310, 280, 310} + } + ,{{ 340, 240, 340, 200, 340} + ,{ 340, 240, 340, 190, 340} + ,{ 310, 200, 310, 150, 310} + ,{ 230, 120, 230, 200, 230} + ,{ 310, 200, 310, 150, 310} + } + ,{{ 310, 260, 310, 150, 310} + ,{ 310, 200, 310, 150, 310} + ,{ 310, 260, 310, 150, 310} + ,{ 310, 200, 310, 150, 310} + ,{ 310, 260, 310, 150, 310} + } + ,{{ 310, 200, 310, 280, 310} + ,{ 310, 200, 310, 280, 310} + ,{ 310, 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310, 260, 220} + } + } + } + } +,{{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + 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INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 310, 300, 270, 310, 290} + ,{ 300, 300, 270, 270, 290} 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260, 260, 220, 220, 220} + } + ,{{ 310, 300, 270, 310, 270} + ,{ 300, 300, 270, 270, 270} + ,{ 310, 290, 250, 310, 250} + ,{ 300, 300, 270, 270, 270} + ,{ 300, 270, 240, 300, 240} + } + ,{{ 260, 260, 220, 220, 220} + ,{ 170, 170, 130, 130, 130} + ,{ 260, 260, 220, 220, 220} + ,{ 210, 110, 80, 210, 80} + ,{ 260, 260, 220, 220, 220} + } + ,{{ 300, 300, 270, 300, 270} + ,{ 300, 300, 270, 270, 270} + ,{ 300, 270, 240, 300, 240} + ,{ 300, 300, 270, 270, 270} + ,{ 240, 240, 150, 150, 150} + } + } + ,{{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 230, 230, 230, 230, 230} + ,{ 230, 230, 230, 230, 230} + ,{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 190} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 190} + ,{ 220, 220, 220, 220, 220} + ,{ 80, 80, 80, 80, 80} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + ,{ 270, 270, 270, 270, 270} + ,{ 150, 150, 150, 150, 150} + } + } + ,{{{ 270, 230, 270, 210, 270} + ,{ 270, 190, 270, 140, 270} + ,{ 250, 230, 250, 120, 250} + ,{ 270, 190, 270, 210, 270} + ,{ 240, 220, 240, 150, 240} + } + ,{{ 230, 150, 230, 130, 230} + ,{ 230, 150, 230, 100, 230} + ,{ 220, 140, 220, 90, 220} + ,{ 130, 50, 130, 130, 130} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 270, 230, 270, 140, 270} + ,{ 270, 190, 270, 140, 270} + ,{ 250, 230, 250, 120, 250} + ,{ 270, 190, 270, 140, 270} + ,{ 240, 220, 240, 110, 240} + } + ,{{ 220, 140, 220, 210, 220} + ,{ 130, 50, 130, 130, 130} + ,{ 220, 140, 220, 90, 220} + ,{ 210, 130, 80, 210, 80} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 270, 220, 270, 150, 270} + ,{ 270, 190, 270, 140, 270} + ,{ 240, 220, 240, 110, 240} + ,{ 270, 190, 270, 140, 270} + ,{ 150, 70, 150, 150, 150} + } + } + ,{{{ 290, 270, 270, 270, 290} + ,{ 290, 270, 270, 270, 290} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 290, 230, 230, 230, 290} + ,{ 290, 230, 230, 230, 290} + ,{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 130} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 250, 250, 250, 250, 250} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 190, 130, 190, 130, 130} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 80, 80, 80, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 270, 270, 270, 270, 270} + ,{ 270, 270, 270, 270, 270} + ,{ 240, 240, 240, 240, 240} + ,{ 270, 270, 270, 270, 270} + ,{ 150, 150, 150, 150, 150} + } + } + } + ,{{{{ 300, 280, 240, 280, 300} + ,{ 300, 280, 240, 240, 300} + ,{ 280, 260, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 250, 220, 280, 220} + } + ,{{ 300, 280, 240, 240, 300} + ,{ 300, 280, 240, 240, 300} + ,{ 250, 250, 220, 220, 220} + ,{ 100, 70, 100, 40, 100} + ,{ 250, 250, 220, 220, 220} + } + ,{{ 280, 250, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 250, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 250, 220, 280, 220} + } + ,{{ 250, 250, 220, 220, 220} + ,{ 160, 140, 160, 100, 160} + ,{ 250, 250, 220, 220, 220} + ,{ 210, 130, 80, 210, 210} + ,{ 250, 250, 220, 220, 220} + } + ,{{ 280, 260, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 260, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 240, 240, 140, 140, 140} + } + } + ,{{{ 280, 280, 240, 280, 240} + ,{ 280, 280, 240, 240, 240} + ,{ 280, 260, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 250, 220, 280, 220} + } + ,{{ 280, 280, 240, 240, 240} + ,{ 280, 280, 240, 240, 240} + ,{ 250, 250, 220, 220, 220} + ,{ 70, 70, 40, 40, 40} + ,{ 250, 250, 220, 220, 220} + } + ,{{ 280, 250, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 250, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 250, 220, 280, 220} + } + ,{{ 250, 250, 220, 220, 220} + ,{ 140, 140, 100, 100, 100} + ,{ 250, 250, 220, 220, 220} + ,{ 210, 110, 80, 210, 80} + ,{ 250, 250, 220, 220, 220} + } + ,{{ 280, 260, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 280, 260, 220, 280, 220} + ,{ 250, 250, 210, 210, 210} + ,{ 240, 240, 140, 140, 140} + } + } + ,{{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ 220, 220, 220, 220, 220} + ,{ 100, 40, 100, 40, 100} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 160, 100, 160, 100, 160} + ,{ 220, 220, 220, 220, 220} + ,{ 80, 80, 80, 80, 80} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 140, 140, 140, 140, 140} + } + } + ,{{{ 240, 200, 240, 210, 240} + ,{ 240, 160, 240, 110, 240} + ,{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 210, 210} + ,{ 220, 200, 220, 140, 220} + } + ,{{ 240, 160, 240, 110, 240} + ,{ 240, 160, 240, 110, 240} + ,{ 220, 140, 220, 90, 220} + ,{ 40, -40, 40, 40, 40} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 220, 200, 220, 90, 220} + } + ,{{ 220, 140, 220, 210, 220} + ,{ 100, 20, 100, 100, 100} + ,{ 220, 140, 220, 90, 220} + ,{ 210, 130, 80, 210, 80} + ,{ 220, 140, 220, 90, 220} + } + ,{{ 220, 200, 220, 140, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 220, 200, 220, 90, 220} + ,{ 210, 130, 210, 80, 210} + ,{ 140, 90, 140, 140, 140} + } + } + ,{{{ 300, 240, 240, 240, 300} + ,{ 300, 240, 240, 240, 300} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 300, 240, 240, 240, 300} + ,{ 300, 240, 240, 240, 300} + ,{ 220, 220, 220, 220, 220} + ,{ 100, 40, 100, 40, 50} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 160, 100, 160, 100, 140} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 80, 80, 80, 210} + ,{ 220, 220, 220, 220, 220} + } + ,{{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 220, 220, 220, 220, 220} + ,{ 210, 210, 210, 210, 210} + ,{ 140, 140, 140, 140, 140} + } + } + } + ,{{{{ 430, 430, 370, 400, 430} + ,{ 430, 410, 370, 370, 430} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 400, 340} + } + ,{{ 430, 410, 370, 370, 430} + ,{ 430, 410, 370, 370, 430} + ,{ 370, 370, 340, 340, 340} + ,{ 320, 290, 320, 260, 320} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + } + ,{{ 370, 370, 360, 340, 360} + ,{ 360, 360, 360, 300, 360} + ,{ 370, 370, 340, 340, 340} + ,{ 340, 260, 210, 340, 340} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 430, 430, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 340, 340} + } + } + ,{{{ 430, 430, 370, 400, 370} + ,{ 410, 410, 370, 370, 370} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 400, 340} + } + ,{{ 410, 410, 370, 370, 370} + ,{ 410, 410, 370, 370, 370} + ,{ 370, 370, 340, 340, 340} + ,{ 290, 290, 260, 260, 260} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + } + ,{{ 370, 370, 340, 340, 340} + ,{ 360, 360, 300, 300, 300} + 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340, 340, 340, 340, 340} + } + } + ,{{{ 370, 320, 370, 340, 370} + ,{ 370, 290, 370, 300, 370} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 340, 340} + ,{ 340, 320, 340, 340, 340} + } + ,{{ 370, 290, 370, 260, 370} + ,{ 370, 290, 370, 240, 370} + ,{ 340, 260, 340, 210, 340} + ,{ 260, 180, 260, 260, 260} + ,{ 340, 260, 340, 210, 340} + } + ,{{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + } + ,{{ 340, 260, 340, 340, 340} + ,{ 300, 220, 300, 300, 300} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 260, 210, 340, 210} + ,{ 340, 260, 340, 210, 340} + } + ,{{ 340, 320, 340, 340, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 260, 340, 340, 340} + } + } + ,{{{ 430, 370, 370, 370, 430} + ,{ 430, 370, 370, 370, 430} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 430, 370, 370, 370, 430} 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310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 400, 340, 400, 340, 340} + ,{ 400, 340, 400, 340, 340} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 180, 180, 180, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + } + } + ,{{{{ 370, 340, 310, 350, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 350, 320, 290, 350, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 350, 320, 290, 350, 290} + } + ,{{ 370, 340, 310, 310, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 320, 320, 280, 280, 280} + ,{ 240, 220, 240, 180, 240} + ,{ 320, 320, 280, 280, 280} + } + ,{{ 350, 330, 290, 350, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 350, 320, 290, 350, 290} + ,{ 330, 330, 290, 290, 290} + ,{ 350, 320, 290, 350, 290} + } + ,{{ 320, 320, 310, 280, 310} 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330, 330, 290, 290, 290} + ,{ 290, 290, 200, 200, 200} + } + } + ,{{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 280, 280, 280, 280, 280} + ,{ 240, 180, 240, 180, 240} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 310, 280, 310, 280, 310} + ,{ 310, 250, 310, 250, 310} + ,{ 280, 280, 280, 280, 280} + ,{ 130, 130, 130, 130, 130} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 200, 200, 200, 200, 200} + } + } + ,{{{ 310, 270, 310, 260, 310} + ,{ 310, 230, 310, 250, 310} + ,{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 260, 290} + ,{ 290, 270, 290, 200, 290} + } + ,{{ 310, 230, 310, 180, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 280, 200, 280, 150, 280} + ,{ 180, 100, 180, 180, 180} + ,{ 280, 200, 280, 150, 280} + } + ,{{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 290, 270, 290, 160, 290} + } + ,{{ 280, 200, 280, 260, 280} + ,{ 250, 170, 250, 250, 250} + ,{ 280, 200, 280, 150, 280} + ,{ 260, 180, 130, 260, 130} + ,{ 280, 200, 280, 150, 280} + } + ,{{ 290, 270, 290, 200, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 290, 270, 290, 160, 290} + ,{ 290, 210, 290, 160, 290} + ,{ 200, 120, 200, 200, 200} + } + } + ,{{{ 370, 310, 310, 310, 370} + ,{ 370, 310, 310, 310, 370} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 370, 310, 310, 310, 370} + ,{ 370, 310, 310, 310, 370} + ,{ 280, 280, 280, 280, 280} + ,{ 240, 180, 240, 180, 180} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + } + ,{{ 310, 280, 310, 280, 280} + ,{ 310, 250, 310, 250, 250} + ,{ 280, 280, 280, 280, 280} + ,{ 260, 130, 130, 130, 260} + ,{ 280, 280, 280, 280, 280} + } + ,{{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 290, 290, 290, 290, 290} + ,{ 200, 200, 200, 200, 200} + } + } + } + ,{{{{ 370, 340, 310, 370, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 370, 340, 310, 370, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 370, 340, 310, 370, 310} + } + ,{{ 370, 340, 310, 310, 370} + ,{ 370, 340, 310, 310, 370} + ,{ 300, 300, 260, 260, 260} + ,{ 260, 240, 260, 200, 260} + ,{ 300, 300, 260, 260, 260} + } + ,{{ 370, 340, 310, 370, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 370, 340, 310, 370, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 370, 340, 310, 370, 310} + } + ,{{ 300, 300, 270, 280, 280} + ,{ 270, 250, 270, 210, 270} + ,{ 300, 300, 260, 260, 260} + ,{ 280, 200, 150, 280, 280} + ,{ 300, 300, 260, 260, 260} + } + ,{{ 340, 340, 310, 340, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 310, 280, 340, 280} + ,{ 340, 340, 310, 310, 310} + ,{ 320, 320, 220, 220, 220} + } + } + ,{{{ 370, 340, 310, 370, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 370, 340, 310, 370, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 370, 340, 310, 370, 310} + } + ,{{ 340, 340, 310, 310, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 300, 300, 260, 260, 260} + ,{ 240, 240, 200, 200, 200} + ,{ 300, 300, 260, 260, 260} + } + ,{{ 370, 340, 310, 370, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 370, 340, 310, 370, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 370, 340, 310, 370, 310} + } + ,{{ 300, 300, 260, 280, 260} + ,{ 250, 250, 210, 210, 210} + ,{ 300, 300, 260, 260, 260} + ,{ 280, 190, 150, 280, 150} + ,{ 300, 300, 260, 260, 260} + } + ,{{ 340, 340, 310, 340, 310} + ,{ 340, 340, 310, 310, 310} + ,{ 340, 310, 280, 340, 280} + ,{ 340, 340, 310, 310, 310} + ,{ 320, 320, 220, 220, 220} + } + } + ,{{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 200, 260, 200, 260} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 270, 260, 270, 260, 270} + ,{ 270, 210, 270, 210, 270} + ,{ 260, 260, 260, 260, 260} + ,{ 150, 150, 150, 150, 150} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 280, 280, 280, 280, 280} + ,{ 310, 310, 310, 310, 310} + ,{ 220, 220, 220, 220, 220} + } + } + ,{{{ 310, 290, 310, 280, 310} + ,{ 310, 230, 310, 210, 310} + ,{ 310, 290, 310, 180, 310} + ,{ 310, 230, 310, 280, 310} + ,{ 310, 290, 310, 220, 310} + } + ,{{ 310, 230, 310, 200, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 260, 180, 260, 130, 260} + ,{ 200, 120, 200, 200, 200} + ,{ 260, 180, 260, 130, 260} + } + ,{{ 310, 290, 310, 180, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 310, 290, 310, 180, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 310, 290, 310, 180, 310} + } + ,{{ 280, 200, 260, 280, 260} + ,{ 210, 130, 210, 210, 210} + ,{ 260, 180, 260, 130, 260} + ,{ 280, 200, 150, 280, 150} + ,{ 260, 180, 260, 130, 260} + } + ,{{ 310, 260, 310, 220, 310} + ,{ 310, 230, 310, 180, 310} + ,{ 280, 260, 280, 150, 280} + ,{ 310, 230, 310, 180, 310} + ,{ 220, 140, 220, 220, 220} + } + } + ,{{{ 370, 310, 310, 310, 370} + ,{ 370, 310, 310, 310, 370} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 370, 310, 310, 310, 370} + ,{ 370, 310, 310, 310, 370} + ,{ 260, 260, 260, 260, 260} + ,{ 260, 200, 260, 200, 200} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + } + ,{{ 280, 260, 270, 260, 280} + ,{ 270, 210, 270, 210, 210} + ,{ 260, 260, 260, 260, 260} + ,{ 280, 150, 150, 150, 280} + ,{ 260, 260, 260, 260, 260} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 280, 280, 280, 280, 280} + ,{ 310, 310, 310, 310, 310} + ,{ 220, 220, 220, 220, 220} + } + } + } + ,{{{{ 430, 430, 400, 400, 430} + ,{ 430, 410, 400, 370, 430} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 400, 340} + } + ,{{ 430, 410, 370, 370, 430} + ,{ 430, 410, 370, 370, 430} + ,{ 370, 370, 340, 340, 340} + ,{ 320, 290, 320, 260, 320} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + } + ,{{ 400, 370, 400, 340, 400} + ,{ 400, 370, 400, 340, 400} + ,{ 370, 370, 340, 340, 340} + ,{ 340, 260, 210, 340, 340} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 430, 430, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 340, 340} + } + } + ,{{{ 430, 430, 370, 400, 370} + ,{ 410, 410, 370, 370, 370} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 400, 340} + } + ,{{ 410, 410, 370, 370, 370} + ,{ 410, 410, 370, 370, 370} + ,{ 370, 370, 340, 340, 340} + ,{ 290, 290, 260, 260, 260} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + } + ,{{ 370, 370, 340, 340, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 340, 240, 210, 340, 210} + ,{ 370, 370, 340, 340, 340} + } + ,{{ 430, 430, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 400, 370, 340, 400, 340} + ,{ 370, 370, 340, 340, 340} + ,{ 430, 430, 340, 340, 340} + } + } + ,{{{ 400, 370, 400, 370, 400} + ,{ 400, 370, 400, 370, 400} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 370, 370, 370, 370, 370} + ,{ 370, 370, 370, 370, 370} + ,{ 340, 340, 340, 340, 340} + ,{ 320, 260, 320, 260, 320} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 400, 340, 400, 340, 400} + ,{ 400, 340, 400, 340, 400} + ,{ 340, 340, 340, 340, 340} + ,{ 210, 210, 210, 210, 210} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + } + ,{{{ 370, 320, 370, 340, 370} + ,{ 370, 290, 370, 340, 370} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 340, 340} + ,{ 340, 320, 340, 340, 340} + } + ,{{ 370, 290, 370, 260, 370} + ,{ 370, 290, 370, 240, 370} + ,{ 340, 260, 340, 210, 340} + ,{ 260, 180, 260, 260, 260} + ,{ 340, 260, 340, 210, 340} + } + ,{{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + } + ,{{ 340, 260, 340, 340, 340} + ,{ 340, 260, 340, 340, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 260, 210, 340, 210} + ,{ 340, 260, 340, 210, 340} + } + ,{{ 340, 320, 340, 340, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 320, 340, 210, 340} + ,{ 340, 260, 340, 210, 340} + ,{ 340, 260, 340, 340, 340} + } + } + ,{{{ 430, 370, 400, 370, 430} + ,{ 430, 370, 400, 370, 430} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 430, 370, 370, 370, 430} + ,{ 430, 370, 370, 370, 430} + ,{ 340, 340, 340, 340, 340} + ,{ 320, 260, 320, 260, 260} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 400, 340, 400, 340, 340} + ,{ 400, 340, 400, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 210, 210, 210, 340} + ,{ 340, 340, 340, 340, 340} + } + ,{{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + ,{ 340, 340, 340, 340, 340} + } + } + } + }}; diff --git a/include/intl22dH.h b/include/intl22dH.h new file mode 100644 --- /dev/null +++ b/include/intl22dH.h @@ -0,0 +1,9993 @@ +PUBLIC int int22_dH[NBPAIRS+1][NBPAIRS+1][5][5][5][5] = +{{{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ 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INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 80, -120, 30, 80, 80} + ,{ 30, -310, -170, 30, -110} + ,{ 80, -230, -110, 80, -60} + ,{ 80, -120, 30, 30, 80} + ,{ -30, -340, -220, -30, -170} + } + ,{{ -120, -460, -290, -120, -230} + ,{ -120, -460, -310, -120, -260} + ,{ -430, -770, -620, -430, -570} + ,{ -230, -670, -290, -980, -230} + ,{ -430, -770, -620, -430, -570} + } + ,{{ 30, -290, -170, 30, -110} + ,{ 30, -310, -170, 30, -110} + ,{ 20, -290, -170, 20, -120} + ,{ 30, 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10, -90} + ,{ 540, -350, -600, 540, -540} + ,{ 180, 180, 30, -320, 180} + ,{ -90, -740, -90, -260, -540} + } + ,{{ -90, -350, -150, -100, -90} + ,{ -90, -580, -150, -200, -90} + ,{ -100, -350, -600, -100, -540} + ,{ -630, -1790, -630, -1790, -1040} + ,{ -400, -740, -600, -400, -540} + } + ,{{ 540, -660, -510, 540, -400} + ,{ 10, -660, -510, 10, -400} + ,{ 540, -940, -820, 540, -760} + ,{ -320, -660, -510, -320, -460} + ,{ -260, -940, -820, -260, -550} + } + ,{{ 180, 180, 30, -400, 180} + ,{ -500, -1070, -500, -1080, -570} + ,{ -400, -740, -600, -400, -540} + ,{ 180, 180, 30, -430, 180} + ,{ -400, -740, -600, -400, -540} + } + ,{{ -90, -660, -90, -210, -460} + ,{ -320, -660, -510, -320, -460} + ,{ -210, -1250, -1130, -210, -1070} + ,{ -320, -660, -510, -320, -460} + ,{ -90, -830, -90, -810, -800} + } + } + ,{{{ 540, 180, -90, 540, 30} + ,{ 10, -580, -220, 10, -150} + ,{ 540, -740, -600, 540, -600} + ,{ 180, 180, -390, -1160, 30} + ,{ -90, -740, -90, -810, -600} + } + ,{{ -100, -580, 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-1790, -630, -1790, -1040} + ,{ -540, -1050, -600, -1050, -540} + } + ,{{ -460, -970, -520, -970, -460} + ,{ -460, -970, -750, -970, -460} + ,{ -760, -1270, -820, -1270, -760} + ,{ -460, -970, -520, -970, -460} + ,{ -550, -1270, -820, -1270, -550} + } + ,{{ 180, -430, 20, -430, 180} + ,{ -500, -1070, -500, -1320, -570} + ,{ -540, -1050, -600, -1050, -540} + ,{ 180, -430, 20, -430, 180} + ,{ -540, -1050, -600, -1050, -540} + } + ,{{ -460, -830, -520, -970, -460} + ,{ -460, -970, -520, -970, -460} + ,{ -1070, -1580, -1130, -1580, -1070} + ,{ -460, -970, -520, -970, -460} + ,{ -830, -830, -1710, -1260, -1460} + } + } + ,{{{ 30, -350, 30, -200, 30} + ,{ -150, -870, -150, -200, -150} + ,{ -210, -350, -600, -210, -600} + ,{ 30, -870, 30, -320, 30} + ,{ -260, -940, -600, -260, -600} + } + ,{{ -150, -350, -150, -200, -150} + ,{ -150, -1600, -150, -200, -150} + ,{ -350, -350, -600, -440, -600} + ,{ -1340, -3070, -1340, -2390, -1340} + ,{ -400, -960, -600, -400, -600} + } + ,{{ -260, -870, -510, -260, -510} + ,{ -320, -1110, -510, -320, -510} + ,{ -620, -940, -820, -620, -820} + ,{ -320, -870, -510, -320, -510} + ,{ -260, -940, -820, -260, -820} + } + ,{{ 30, -960, 30, -400, 30} + ,{ -860, -1880, -860, -1080, -860} + ,{ -400, -960, -600, -400, -600} + ,{ 30, -1370, 30, -2280, 30} + ,{ -400, -960, -600, -400, -600} + } + ,{{ -210, -870, -510, -210, -510} + ,{ -320, -870, -510, -320, -510} + ,{ -210, -1250, -1130, -210, -1130} + ,{ -320, -870, -510, -320, -510} + ,{ -800, -1360, -800, -1550, -800} + } + } + ,{{{ -200, -430, -200, -430, -230} + ,{ -200, -600, -200, -600, -400} + ,{ -650, -1050, -650, -1050, -1390} + ,{ -230, -430, -570, -430, -230} + ,{ -650, -1050, -650, -1050, -1390} + } + ,{{ -200, -600, -200, -600, -1390} + ,{ -200, -600, -200, -600, -1490} + ,{ -650, -1050, -650, -1050, -1390} + ,{ -1150, -1790, -1150, -1790, -1520} + ,{ -650, -1050, -650, -1050, -1390} + } + ,{{ -400, -970, -570, -970, -400} + ,{ -400, -970, -570, -970, -400} + ,{ -870, -1270, -870, -1270, -1610} + ,{ -570, -970, -570, -970, -1300} + ,{ -870, -1270, -870, -1270, -1610} + } + ,{{ -230, -430, -650, -430, -230} + ,{ -1300, -1320, -1750, -1320, -1300} + ,{ -650, -1050, -650, -1050, -1390} + ,{ -230, -430, -880, -430, -230} + ,{ -650, -1050, -650, -1050, -1390} + } + ,{{ -570, -970, -570, -970, -1300} + ,{ -570, -970, -570, -970, -1300} + ,{ -1180, -1580, -1180, -1580, -1920} + ,{ -570, -970, -570, -970, -1300} + ,{ -860, -1260, -860, -1260, -2350} + } + } + } + ,{{{{ 240, 40, 190, -270, 240} + ,{ -590, -1030, -650, -870, -590} + ,{ -870, -1180, -1060, -870, -1010} + ,{ 240, 40, 190, -270, 240} + ,{ -870, -970, -1060, -870, -1010} + } + ,{{ -780, -1210, -840, -870, -780} + ,{ -1050, -1370, -1240, -1050, -1190} + ,{ -870, -1210, -1060, -870, -1010} + ,{ -780, -1220, -840, -1530, -780} + ,{ -870, -1210, -1060, -870, -1010} + } + ,{{ -870, -1180, -1060, -870, -1010} + ,{ -870, -1210, -1060, -870, -1010} + ,{ -870, -1180, -1060, -870, -1010} + ,{ -870, -1210, -1060, -870, -1010} + ,{ -870, -1180, -1060, -870, -1010} + } + ,{{ 240, 40, 190, -270, 240} + ,{ -590, -1030, -650, -1340, -590} + ,{ -870, -1210, -1060, -870, -1010} + ,{ 240, 40, 190, -270, 240} + ,{ -870, -1210, -1060, -870, -1010} + } + ,{{ -870, -970, -1060, -870, -1010} + ,{ -870, -1210, -1060, -870, -1010} + ,{ -870, -1180, -1060, -870, -1010} + ,{ -870, -1210, -1060, -870, -1010} + ,{ -970, -970, -1060, -1520, -1010} + } + } + ,{{{ 190, 40, 190, -1470, 190} + ,{ -890, -1030, -890, -1530, -890} + ,{ -1060, -1210, -1060, -1470, -1060} + ,{ 190, 40, 190, -1710, 190} + ,{ -970, -970, -1060, -1470, -1060} + } + ,{{ -1060, -1210, -1060, -1710, -1060} + ,{ -1240, -1370, -1240, -1890, -1240} + ,{ -1060, -1210, -1060, -1710, -1060} + ,{ -1080, -1220, -1080, -1720, -1080} + ,{ -1060, -1210, -1060, -1710, -1060} + } + ,{{ -1060, -1210, -1060, -1470, -1060} + ,{ -1060, -1210, -1060, -1710, -1060} + ,{ -1060, -1210, -1060, -1470, -1060} + ,{ -1060, -1210, -1060, -1710, -1060} + ,{ -1060, -1210, -1060, -1470, -1060} + } + ,{{ 190, 40, 190, -1530, 190} + ,{ -890, -1030, -890, -1530, -890} + ,{ -1060, -1210, -1060, -1710, -1060} + ,{ 190, 40, 190, -1710, 190} + ,{ -1060, -1210, -1060, -1710, -1060} + } + ,{{ -970, -970, -1060, -1470, -1060} + ,{ -1060, -1210, -1060, -1710, -1060} + ,{ -1060, -1210, -1060, -1470, -1060} + ,{ -1060, -1210, -1060, -1710, -1060} + ,{ -970, -970, -1060, -1710, -1060} + } + } + ,{{{ 240, -270, 180, -270, 240} + ,{ -590, -1340, -650, -1340, -590} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ 240, -270, 180, -270, 240} + ,{ -1010, -1520, -1070, -1520, -1010} + } + ,{{ -780, -1520, -840, -1520, -780} + ,{ -1190, -1700, -1250, -1700, -1190} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ -780, -1530, -840, -1530, -780} + ,{ -1010, -1520, -1070, -1520, -1010} + } + ,{{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + } + ,{{ 240, -270, 180, -270, 240} + ,{ -590, -1340, -650, -1340, -590} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ 240, -270, 180, -270, 240} + ,{ -1010, -1520, -1070, -1520, -1010} + } + ,{{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + ,{ -1010, -1520, -1070, -1520, -1010} + } + } + ,{{{ 190, -1180, 190, -870, 190} + ,{ -870, -1250, -890, -870, -890} + ,{ -870, -1180, -1060, -870, -1060} + ,{ 190, -1420, 190, -870, 190} + ,{ -870, -1180, -1060, -870, -1060} + } + ,{{ -870, -1420, -1060, -870, -1060} + ,{ -1050, -1600, -1240, -1050, -1240} + ,{ -870, -1420, -1060, -870, -1060} + ,{ -1080, -1440, -1080, -2130, -1080} + ,{ -870, -1420, -1060, -870, -1060} + } + ,{{ -870, -1180, -1060, -870, -1060} + ,{ -870, -1420, -1060, -870, -1060} + ,{ -870, -1180, -1060, -870, -1060} + ,{ -870, -1420, -1060, -870, -1060} + ,{ -870, -1180, -1060, -870, -1060} + } + ,{{ 190, -1250, 190, -870, 190} 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-1340, -700, -1340, -1680} + ,{ -1120, -1520, -1120, -1520, -1850} + ,{ 130, -270, 130, -270, -1850} + ,{ -1120, -1520, -1120, -1520, -1850} + } + ,{{ -1120, -1520, -1120, -1520, -1850} + ,{ -1120, -1520, -1120, -1520, -1850} + ,{ -1120, -1520, -1120, -1520, -1850} + ,{ -1120, -1520, -1120, -1520, -1850} + ,{ -1120, -1520, -1120, -1520, -1850} + } + } + } + ,{{{{ 800, 600, 740, 290, 800} + ,{ 200, -140, 0, 200, 50} + ,{ -310, -630, -510, -310, -450} + ,{ 800, 600, 740, 290, 800} + ,{ -310, -410, -510, -310, -450} + } + ,{{ 200, -140, 0, 200, 50} + ,{ 200, -140, 0, 200, 50} + ,{ -310, -650, -510, -310, -450} + ,{ -550, -990, -610, -1300, -550} + ,{ -310, -650, -510, -310, -450} + } + ,{{ -310, -630, -510, -310, -450} + ,{ -310, -650, -510, -310, -450} + ,{ -310, -630, -510, -310, -450} + ,{ -310, -650, -510, -310, -450} + ,{ -310, -630, -510, -310, -450} + } + ,{{ 800, 600, 740, 290, 800} + ,{ -720, -1160, -780, -1470, -720} + ,{ -310, -650, -510, -310, -450} + ,{ 800, 600, 740, 290, 800} + ,{ -310, -650, -510, -310, -450} + } + ,{{ -310, -410, -510, -310, -450} + ,{ -310, -650, -510, -310, -450} + ,{ -310, -630, -510, -310, -450} + ,{ -310, -650, -510, -310, -450} + ,{ -410, -410, -510, -960, -450} + } + } + ,{{{ 740, 600, 740, -640, 740} + ,{ 0, -140, 0, -640, 0} + ,{ -510, -650, -510, -910, -510} + ,{ 740, 600, 740, -1150, 740} + ,{ -410, -410, -510, -910, -510} + } + ,{{ 0, -140, 0, -640, 0} + ,{ 0, -140, 0, -640, 0} + ,{ -510, -650, -510, -1150, -510} + ,{ -850, -990, -850, -1490, -850} + ,{ -510, -650, -510, -1150, -510} + } + ,{{ -510, -650, -510, -910, -510} + ,{ -510, -650, -510, -1150, -510} + ,{ -510, -650, -510, -910, -510} + ,{ -510, -650, -510, -1150, -510} + ,{ -510, -650, -510, -910, -510} + } + ,{{ 740, 600, 740, -1150, 740} + ,{ -1020, -1160, -1020, -1660, -1020} + ,{ -510, -650, -510, -1150, -510} + ,{ 740, 600, 740, -1150, 740} + ,{ -510, -650, -510, -1150, -510} + } + ,{{ -410, -410, -510, -910, -510} + ,{ -510, -650, -510, -1150, -510} + ,{ -510, -650, -510, -910, -510} + ,{ -510, -650, -510, -1150, -510} + ,{ -410, -410, -510, -1150, -510} + } + } + ,{{{ 800, 290, 740, 290, 800} + ,{ 50, -450, 0, -450, 50} + ,{ -450, -960, -510, -960, -450} + ,{ 800, 290, 740, 290, 800} + ,{ -450, -960, -510, -960, -450} + } + ,{{ 50, -450, 0, -450, 50} + ,{ 50, -450, 0, -450, 50} + ,{ -450, -960, -510, -960, -450} + ,{ -550, -1300, -610, -1300, -550} + ,{ -450, -960, -510, -960, -450} + } + ,{{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + } + ,{{ 800, 290, 740, 290, 800} + ,{ -720, -1470, -780, -1470, -720} + ,{ -450, -960, -510, -960, -450} + ,{ 800, 290, 740, 290, 800} + ,{ -450, -960, -510, -960, -450} + } + ,{{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + ,{ -450, -960, -510, -960, -450} + } + } + ,{{{ 740, -360, 740, 200, 740} + ,{ 200, -360, 0, 200, 0} + ,{ -310, -630, -510, -310, -510} + ,{ 740, -870, 740, -310, 740} + ,{ -310, -630, -510, -310, -510} + } + ,{{ 200, -360, 0, 200, 0} + ,{ 200, -360, 0, 200, 0} + ,{ -310, -870, -510, -310, -510} + ,{ -850, -1210, -850, -1900, -850} + ,{ -310, -870, -510, -310, -510} + } + ,{{ -310, -630, -510, -310, -510} + ,{ -310, -870, -510, -310, -510} + ,{ -310, -630, -510, -310, -510} + ,{ -310, -870, -510, -310, -510} + ,{ -310, -630, -510, -310, -510} + } + ,{{ 740, -870, 740, -310, 740} + ,{ -1020, -1380, -1020, -2070, -1020} + ,{ -310, -870, -510, -310, -510} + ,{ 740, -870, 740, -1560, 740} + ,{ -310, -870, -510, -310, -510} + } + ,{{ -310, -630, -510, -310, -510} + ,{ -310, -870, -510, -310, -510} + ,{ -310, -630, -510, -310, -510} + ,{ -310, -870, -510, -310, -510} + ,{ -510, -870, -510, -1560, -510} + } + } + ,{{{ 690, 290, 690, 290, -550} + ,{ -50, -450, -50, -450, -550} + ,{ -560, -960, -560, -960, -1300} + ,{ 690, 290, 690, 290, -1300} + ,{ -560, -960, -560, -960, -1300} + } + ,{{ -50, -450, -50, -450, -550} + ,{ -50, -450, -50, -450, -550} + ,{ -560, -960, -560, -960, -1300} + ,{ -660, -1300, -660, -1300, -1640} + ,{ -560, -960, -560, -960, -1300} + } + ,{{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + } + ,{{ 690, 290, 690, 290, -1300} + ,{ -830, -1470, -830, -1470, -1810} + ,{ -560, -960, -560, -960, -1300} + ,{ 690, 290, 690, 290, -1300} + ,{ -560, -960, -560, -960, -1300} + } + ,{{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + ,{ -560, -960, -560, -960, -1300} + } + } + } + ,{{{{ 1170, 970, 1120, 780, 1170} + ,{ 780, 440, 580, 780, 640} + ,{ 480, 170, 280, 480, 340} + ,{ 1170, 970, 1120, 660, 1170} + ,{ 480, 170, 280, 480, 340} + } + ,{{ 780, 440, 580, 780, 640} + ,{ 780, 440, 580, 780, 640} + ,{ 470, 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370} + } + ,{{ 720, 160, 520, 720, 520} + ,{ 720, 160, 520, 720, 520} + ,{ 280, -40, 80, 280, 80} + ,{ 720, 160, 520, 720, 520} + ,{ -420, -780, -420, -1470, -420} + } + } + ,{{{ 1250, 850, 1250, 850, 100} + ,{ 590, 190, 590, 190, 100} + ,{ 460, 60, 460, 60, -270} + ,{ 1250, 850, 1250, 850, -270} + ,{ 330, -60, 330, -60, -400} + } + ,{{ 590, 190, 590, 190, 100} + ,{ 590, 190, 590, 190, 100} + ,{ 310, -80, 310, -80, -420} + ,{ -570, -1210, -570, -1210, -1540} + ,{ 310, -80, 310, -80, -420} + } + ,{{ 460, 60, 460, 60, -270} + ,{ 460, 60, 460, 60, -270} + ,{ 460, 60, 460, 60, -270} + ,{ 460, 60, 460, 60, -270} + ,{ 330, -60, 330, -60, -400} + } + ,{{ 1250, 850, 1250, 850, -420} + ,{ -870, -1510, -870, -1510, -1840} + ,{ 310, -80, 310, -80, -420} + ,{ 1250, 850, 1250, 850, -740} + ,{ 310, -80, 310, -80, -420} + } + ,{{ 460, 60, 460, 60, -270} + ,{ 460, 60, 460, 60, -270} + ,{ 20, -370, 20, -370, -710} + ,{ 460, 60, 460, 60, -270} + ,{ -470, -870, -470, -870, -1210} + } + } + } + ,{{{{ 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-470, -870, -470, -870, -1210} + } + } + } + } +,{{{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 540, -90, 540, 180, -90} + ,{ 540, -100, 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-1580} + ,{ -350, -350, -940, -960, -1250} + ,{ -1050, -1050, -1270, -1050, -1580} + } + ,{{ -600, -600, -820, -600, -1130} + ,{ -600, -600, -820, -600, -1130} + ,{ -600, -600, -820, -600, -1130} + ,{ -600, -600, -820, -600, -1130} + ,{ -650, -650, -870, -650, -1180} + } + ,{{ 540, -100, 540, -400, -210} + ,{ 540, -100, 540, -1240, -1530} + ,{ -1050, -1050, -1270, -1050, -1580} + ,{ -210, -440, -620, -400, -210} + ,{ -1050, -1050, -1270, -1050, -1580} + } + ,{{ -540, -540, -760, -540, -1070} + ,{ -600, -600, -820, -600, -1130} + ,{ -540, -540, -760, -540, -1070} + ,{ -600, -600, -820, -600, -1130} + ,{ -1390, -1390, -1610, -1390, -1920} + } + } + ,{{{ 180, -630, -320, 180, -320} + ,{ 180, -1340, -510, 180, -510} + ,{ 180, -630, -460, 180, -460} + ,{ 30, -1340, -320, 30, -320} + ,{ -230, -1150, -570, -230, -570} + } + ,{{ 180, -1790, -660, 180, -660} + ,{ 180, -2010, -660, 180, -660} + ,{ -430, -1790, -970, -430, -970} + ,{ -870, -3070, -870, -1370, -870} + ,{ -430, -1790, -970, -430, 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-490, -850, -310, -850} + ,{ -250, -250, -850, -940, -850} + } + } + ,{{{ 760, 760, 400, -690, 400} + ,{ -340, -490, -340, -690, -340} + ,{ -490, -490, -850, -960, -850} + ,{ 760, 760, 400, -1200, 400} + ,{ -250, -250, -850, -960, -850} + } + ,{{ -340, -490, -340, -690, -340} + ,{ -340, -2040, -340, -690, -340} + ,{ -490, -490, -850, -1200, -850} + ,{ -830, -830, -1190, -1540, -1190} + ,{ -490, -490, -850, -1200, -850} + } + ,{{ -490, -490, -850, -960, -850} + ,{ -490, -490, -850, -1200, -850} + ,{ -490, -490, -850, -960, -850} + ,{ -490, -490, -850, -1200, -850} + ,{ -490, -490, -850, -960, -850} + } + ,{{ 760, 760, 400, -1200, 400} + ,{ -1000, -1000, -1360, -1710, -1360} + ,{ -490, -490, -850, -1200, -850} + ,{ 760, 760, 400, -1200, 400} + ,{ -490, -490, -850, -1200, -850} + } + ,{{ -250, -250, -850, -960, -850} + ,{ -490, -490, -850, -1200, -850} + ,{ -490, -490, -850, -960, -850} + ,{ -490, -490, -850, -1200, -850} + ,{ -250, -250, -850, -1200, -850} + } + } + ,{{{ 310, 310, 90, 310, -220} + ,{ -430, -430, -650, -430, -960} + ,{ -940, -940, -1160, -940, -1470} + ,{ 310, 310, 90, 310, -220} + ,{ -940, -940, -1160, -940, -1470} + } + ,{{ -430, -430, -650, -430, -960} + ,{ -430, -430, -650, -430, -960} + ,{ -940, -940, -1160, -940, -1470} + ,{ -1260, -1280, -1260, -1280, -1570} + ,{ -940, -940, -1160, -940, -1470} + } + ,{{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + } + ,{{ 310, 310, 90, 310, -220} + ,{ -1430, -1450, -1430, -1450, -1740} + ,{ -940, -940, -1160, -940, -1470} + ,{ 310, 310, 90, 310, -220} + ,{ -940, -940, -1160, -940, -1470} + } + ,{{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + ,{ -940, -940, -1160, -940, -1470} + } + } + ,{{{ 400, -1170, 400, 200, 400} + ,{ 200, -1170, -340, 200, -340} + ,{ -310, -1440, -850, -310, -850} + ,{ 400, -1680, 400, -310, 400} + ,{ -310, -1440, -850, -310, -850} + } + ,{{ 200, -1170, -340, 200, -340} + ,{ 200, -1170, -340, 200, -340} + ,{ -310, -1680, -850, -310, -850} + ,{ -1190, -2020, -1190, -1900, -1190} + ,{ -310, -1680, -850, -310, -850} + } + ,{{ -310, -1440, -850, -310, -850} + ,{ -310, -1680, -850, -310, -850} + ,{ -310, -1440, -850, -310, -850} + ,{ -310, -1680, -850, -310, -850} + ,{ -310, -1440, -850, -310, -850} + } + ,{{ 400, -1680, 400, -310, 400} + ,{ -1360, -2190, -1360, -2070, -1360} + ,{ -310, -1680, -850, -310, -850} + ,{ 400, -1680, 400, -1560, 400} + ,{ -310, -1680, -850, -310, -850} + } + ,{{ -310, -1440, -850, -310, -850} + ,{ -310, -1680, -850, -310, -850} + ,{ -310, -1440, -850, -310, -850} + ,{ -310, -1680, -850, -310, -850} + ,{ -850, -1680, -850, -1560, -850} + } + } + ,{{{ 310, 310, 90, 310, -390} + ,{ -390, -430, -650, -430, -390} + ,{ -940, -940, -1160, -940, -1140} + ,{ 310, 310, 90, 310, -1140} + ,{ -940, -940, -1160, -940, -1140} + } + ,{{ -390, -430, -650, -430, -390} + ,{ -390, -430, -650, -430, -390} + ,{ -940, -940, -1160, -940, -1140} + ,{ -1260, -1280, -1260, -1280, -1480} + ,{ -940, -940, -1160, -940, -1140} + } + ,{{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + } + ,{{ 310, 310, 90, 310, -1140} + ,{ -1430, -1450, -1430, -1450, -1650} + ,{ -940, -940, -1160, -940, -1140} + ,{ 310, 310, 90, 310, -1140} + ,{ -940, -940, -1160, -940, -1140} + } + ,{{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + ,{ -940, -940, -1160, -940, -1140} + } + } + } + ,{{{{ 1140, 1140, 770, 780, 770} + ,{ 780, 600, 240, 780, 240} + ,{ 480, 300, -60, 480, -60} + ,{ 1140, 1140, 770, 690, 770} + ,{ 480, 300, -60, 480, -60} + } + ,{{ 780, 600, 240, 780, 240} + ,{ 780, 600, 240, 780, 240} + ,{ 470, 290, -70, 470, -70} + ,{ -780, -780, -1150, -1230, -1150} + ,{ 470, 290, -70, 470, -70} + } + ,{{ 490, 310, -50, 490, -50} + ,{ 490, 310, -50, 490, -50} + ,{ 480, 300, -60, 480, -60} + ,{ 490, 310, -50, 490, -50} + ,{ 480, 300, -60, 480, -60} + } + ,{{ 1140, 1140, 770, 690, 770} + ,{ -600, -600, -970, -1050, -970} + ,{ 470, 290, -70, 470, -70} + ,{ 1140, 1140, 770, 690, 770} + ,{ 470, 290, -70, 470, -70} + } + ,{{ 490, 310, -50, 490, -50} + ,{ 490, 310, -50, 490, -50} + ,{ 480, 300, -60, 480, -60} + ,{ 490, 310, -50, 490, -50} + ,{ -430, -430, -1040, -1120, -1040} + } + } + ,{{{ 1140, 1140, 770, -110, 770} + ,{ 600, 600, 240, -110, 240} + ,{ 300, 300, -60, -170, -60} + ,{ 1140, 1140, 770, -400, 770} + ,{ 300, 300, -60, -170, -60} + } + ,{{ 600, 600, 240, -110, 240} + ,{ 600, 600, 240, -110, 240} + ,{ 290, 290, -70, -420, -70} + ,{ -780, -780, -1150, -1500, -1150} + ,{ 290, 290, -70, -420, -70} + } + ,{{ 310, 310, -50, -170, -50} + ,{ 310, 310, -50, -400, -50} + ,{ 300, 300, -60, -170, -60} 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INF} + } + } + } + ,{{{{ 240, -780, -870, 240, -870} + ,{ 190, -1060, -1060, 190, -970} + ,{ 240, -780, -1010, 240, -1010} + ,{ 190, -870, -870, 190, -870} + ,{ 130, -890, -1120, 130, -1120} + } + ,{{ 40, -1210, -1180, 40, -970} + ,{ 40, -1210, -1210, 40, -970} + ,{ -270, -1520, -1520, -270, -1520} + ,{ -1180, -1420, -1180, -1250, -1180} + ,{ -270, -1520, -1520, -270, -1520} + } + ,{{ 190, -840, -1060, 190, -1060} + ,{ 190, -1060, -1060, 190, -1060} + ,{ 180, -840, -1070, 180, -1070} + ,{ 190, -1060, -1060, 190, -1060} + ,{ 130, -890, -1120, 130, -1120} + } + ,{{ -270, -870, -870, -270, -870} + ,{ -1470, -1710, -1470, -1530, -1470} + ,{ -270, -1520, -1520, -270, -1520} + ,{ -870, -870, -870, -870, -870} + ,{ -270, -1520, -1520, -270, -1520} + } + ,{{ 240, -780, -1010, 240, -1010} + ,{ 190, -1060, -1060, 190, -1060} + ,{ 240, -780, -1010, 240, -1010} + ,{ 190, -1060, -1060, 190, -1060} + ,{ -1680, -1790, -1850, -1680, -1850} + } + } + ,{{{ -590, -1050, -870, -590, -870} + ,{ -890, 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880, -370, -370, 880, -370} + ,{ -1140, -1250, -1310, -1140, -1310} + } + } + ,{{{ 410, 230, 410, 40, 410} + ,{ -70, -420, -240, -70, -240} + ,{ 40, -550, -370, 40, -370} + ,{ 410, 230, 410, -200, 410} + ,{ -90, -680, -500, -90, -500} + } + ,{{ -70, -420, -240, -70, -240} + ,{ -70, -420, -240, -70, -240} + ,{ -350, -700, -520, -350, -520} + ,{ -1470, -1830, -1650, -1470, -1650} + ,{ -350, -700, -520, -350, -520} + } + ,{{ 40, -550, -370, 40, -370} + ,{ -200, -550, -370, -200, -370} + ,{ 40, -550, -370, 40, -370} + ,{ -200, -550, -370, -200, -370} + ,{ -90, -680, -500, -90, -500} + } + ,{{ 410, 230, 410, -350, 410} + ,{ -1770, -2130, -1950, -1770, -1950} + ,{ -350, -700, -520, -350, -520} + ,{ 410, 230, 410, -670, 410} + ,{ -350, -700, -520, -350, -520} + } + ,{{ -200, -550, -370, -200, -370} + ,{ -200, -550, -370, -200, -370} + ,{ -400, -990, -810, -400, -810} + ,{ -200, -550, -370, -200, -370} + ,{ -1140, -1250, -1310, -1140, -1310} + } + } + ,{{{ 410, 410, 410, 410, 410} + ,{ -240, 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+ ,{{ -510, -510, -510, -510, -510} + ,{ -510, -510, -510, -510, -510} + ,{ -510, -510, -510, -510, -510} + ,{ -510, -510, -510, -510, -510} + ,{ -560, -560, -560, -560, -560} + } + ,{{ -310, -310, -310, -310, -310} + ,{ -910, -1150, -910, -1150, -910} + ,{ -960, -960, -960, -960, -960} + ,{ -310, -310, -310, -310, -310} + ,{ -960, -960, -960, -960, -960} + } + ,{{ -450, -450, -450, -450, -450} + ,{ -510, -510, -510, -510, -510} + ,{ -450, -450, -450, -450, -450} + ,{ -510, -510, -510, -510, -510} + ,{ -1300, -1300, -1300, -1300, -1300} + } + } + ,{{{ 800, -550, -310, 800, -310} + ,{ 740, -850, -510, 740, -510} + ,{ 800, -550, -450, 800, -450} + ,{ 740, -850, -310, 740, -310} + ,{ 690, -660, -560, 690, -560} + } + ,{{ 600, -990, -650, 600, -650} + ,{ 600, -990, -650, 600, -650} + ,{ 290, -1300, -960, 290, -960} + ,{ -870, -1210, -870, -870, -870} + ,{ 290, -1300, -960, 290, -960} + } + ,{{ 740, -610, -510, 740, -510} + ,{ 740, -850, -510, 740, -510} + ,{ 740, -610, -510, 740, -510} + ,{ 740, -850, -510, 740, -510} + ,{ 690, -660, -560, 690, -560} + } + ,{{ 290, -1300, -310, 290, -310} + ,{ -1150, -1490, -1150, -1150, -1150} + ,{ 290, -1300, -960, 290, -960} + ,{ -310, -1900, -310, -1560, -310} + ,{ 290, -1300, -960, 290, -960} + } + ,{{ 800, -550, -450, 800, -450} + ,{ 740, -850, -510, 740, -510} + ,{ 800, -550, -450, 800, -450} + ,{ 740, -850, -510, 740, -510} + ,{ -1300, -1640, -1300, -1300, -1300} + } + } + ,{{{ -310, -310, -310, -310, -410} + ,{ -410, -510, -510, -510, -410} + ,{ -450, -450, -450, -450, -450} + ,{ -310, -310, -310, -310, -510} + ,{ -560, -560, -560, -560, -560} + } + ,{{ -410, -650, -630, -650, -410} + ,{ -410, -650, -650, -650, -410} + ,{ -960, -960, -960, -960, -960} + ,{ -630, -870, -630, -870, -870} + ,{ -960, -960, -960, -960, -960} + } + ,{{ -510, -510, -510, -510, -510} + ,{ -510, -510, -510, -510, -510} + ,{ -510, -510, -510, -510, -510} + ,{ -510, -510, -510, -510, -510} + ,{ -560, -560, -560, -560, -560} + } + ,{{ -310, -310, -310, -310, -960} + ,{ -910, -1150, -910, -1150, -1150} + ,{ -960, -960, -960, -960, -960} + ,{ -310, -310, -310, -310, -1560} + ,{ -960, -960, -960, -960, -960} + } + ,{{ -450, -450, -450, -450, -450} + ,{ -510, -510, -510, -510, -510} + ,{ -450, -450, -450, -450, -450} + ,{ -510, -510, -510, -510, -510} + ,{ -1300, -1300, -1300, -1300, -1300} + } + } + } + ,{{{{ 760, 200, -310, 760, -250} + ,{ 760, -340, -490, 760, -250} + ,{ 310, -430, -940, 310, -940} + ,{ 400, 200, -310, 400, -310} + ,{ 310, -390, -940, 310, -940} + } + ,{{ 760, -430, -490, 760, -250} + ,{ 760, -490, -490, 760, -250} + ,{ 310, -430, -940, 310, -940} + ,{ -1170, -1170, -1440, -1680, -1440} + ,{ 310, -430, -940, 310, -940} + } + ,{{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ 90, -650, -1160, 90, -1160} + ,{ 400, -340, -850, 400, -850} + ,{ 90, -650, -1160, 90, -1160} + } + ,{{ 310, 200, -310, 310, -310} + ,{ -690, -690, -960, -1200, -960} + ,{ 310, -430, -940, 310, -940} + ,{ 200, 200, -310, -310, -310} + ,{ 310, -430, -940, 310, -940} + } + ,{{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ -220, -960, -1470, -220, -1470} + ,{ 400, -340, -850, 400, -850} + ,{ -390, -390, -1140, -1140, -1140} + } + } + ,{{{ 200, 200, -310, -1000, -310} + ,{ -340, -340, -490, -1000, -490} + ,{ -430, -430, -940, -1430, -940} + ,{ 200, 200, -310, -1360, -310} + ,{ -390, -390, -940, -1430, -940} + } + ,{{ -430, -430, -490, -1000, -490} + ,{ -490, -2040, -490, -1000, -490} + ,{ -430, -430, -940, -1450, -940} + ,{ -1170, -1170, -1680, -2190, -1680} + ,{ -430, -430, -940, -1450, -940} + } + ,{{ -340, -340, -850, -1360, -850} + ,{ -340, -340, -850, -1360, -850} + ,{ -650, -650, -1160, -1430, -1160} + ,{ -340, -340, -850, -1360, -850} + ,{ -650, -650, -1160, -1430, -1160} + } + ,{{ 200, 200, -310, -1450, -310} + ,{ -690, -690, -1200, -1710, -1200} + ,{ -430, -430, -940, -1450, -940} + ,{ 200, 200, -310, -2070, -310} + ,{ -430, -430, -940, -1450, -940} + } + ,{{ -340, -340, -850, -1360, -850} + ,{ -340, -340, -850, -1360, -850} + ,{ -960, -960, -1470, -1740, -1470} + ,{ -340, -340, -850, -1360, -850} + ,{ -390, -390, -1140, -1650, -1140} + } + } + ,{{{ -310, -310, -310, -310, -310} + ,{ -490, -490, -490, -490, -490} + ,{ -940, -940, -940, -940, -940} + ,{ -310, -310, -310, -310, -310} + ,{ -940, -940, -940, -940, -940} + } + ,{{ -490, -490, -490, -490, -490} + ,{ -490, -490, -490, -490, -490} + ,{ -940, -940, -940, -940, -940} + ,{ -1440, -1680, -1440, -1680, -1440} + ,{ -940, -940, -940, -940, -940} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -1160, -1160, -1160, -1160, -1160} + ,{ -850, -850, -850, -850, -850} + ,{ -1160, -1160, -1160, -1160, -1160} + } + ,{{ -310, -310, -310, -310, -310} + ,{ -960, -1200, -960, -1200, -960} + ,{ -940, -940, -940, -940, -940} + ,{ -310, -310, -310, -310, -310} + ,{ -940, -940, -940, -940, -940} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -1470, -1470, -1470, -1470, -1470} + ,{ -850, -850, -850, -850, -850} + ,{ -1140, -1140, -1140, -1140, -1140} + } + } + ,{{{ 760, -830, -310, 760, -310} + ,{ 760, -830, -490, 760, -490} + ,{ 310, -1260, -940, 310, -940} + ,{ 400, -1190, -310, 400, -310} + ,{ 310, -1260, -940, 310, -940} + } + ,{{ 760, -830, -490, 760, -490} + ,{ 760, -830, -490, 760, -490} + ,{ 310, -1280, -940, 310, -940} + ,{ -1680, -2020, -1680, -1680, -1680} + ,{ 310, -1280, -940, 310, -940} + } + ,{{ 400, -1190, -850, 400, -850} + ,{ 400, -1190, -850, 400, -850} + ,{ 90, -1260, -1160, 90, -1160} + ,{ 400, -1190, -850, 400, -850} + ,{ 90, -1260, -1160, 90, -1160} + } + ,{{ 310, -1280, -310, 310, -310} + ,{ -1200, -1540, -1200, -1200, -1200} + ,{ 310, -1280, -940, 310, -940} + ,{ -310, -1900, -310, -1560, -310} + ,{ 310, -1280, -940, 310, -940} + } + ,{{ 400, -1190, -850, 400, -850} + ,{ 400, -1190, -850, 400, -850} + ,{ -220, -1570, -1470, -220, -1470} + ,{ 400, -1190, -850, 400, -850} + ,{ -1140, -1480, -1140, -1140, -1140} + } + } + ,{{{ -250, -310, -310, -310, -250} + ,{ -250, -490, -490, -490, -250} + ,{ -940, -940, -940, -940, -940} + ,{ -310, -310, -310, -310, -850} + ,{ -940, -940, -940, -940, -940} + } + ,{{ -250, -490, -490, -490, -250} + ,{ -250, -490, -490, -490, -250} + ,{ -940, -940, -940, -940, -940} + ,{ -1440, -1680, -1440, -1680, -1680} + ,{ -940, -940, -940, -940, -940} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -1160, -1160, -1160, -1160, -1160} + ,{ -850, -850, -850, -850, -850} + ,{ -1160, -1160, -1160, -1160, -1160} + } + ,{{ -310, -310, -310, -310, -940} + ,{ -960, -1200, -960, -1200, -1200} + ,{ -940, -940, -940, -940, -940} + ,{ -310, -310, -310, -310, -1560} + ,{ -940, -940, -940, -940, -940} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -1470, -1470, -1470, -1470, -1470} + ,{ -850, -850, -850, -850, -850} + ,{ -1140, -1140, -1140, -1140, -1140} + } + } + } + ,{{{{ 360, 360, -150, -150, -150} + ,{ -30, -30, -990, -150, -990} + ,{ -150, -890, -1400, -150, -1400} + ,{ 360, 360, -150, -150, -150} + ,{ -150, -650, -1400, -150, -1400} + } + ,{{ -70, -70, -1180, -150, -1180} + ,{ -70, -70, -1580, -330, -1340} + ,{ -150, -890, -1400, -150, -1400} + ,{ -910, -910, -1180, -1420, -1180} + ,{ -150, -890, -1400, -150, -1400} + } + ,{{ -150, -890, -1400, -150, -1400} + ,{ -150, -890, -1400, -150, -1400} + ,{ -150, -890, -1400, -150, -1400} + ,{ -150, -890, -1400, -150, -1400} + ,{ -150, -890, -1400, -150, -1400} + } + ,{{ 360, 360, -150, -150, -150} + ,{ -30, -30, -990, -1230, -990} + ,{ -150, -890, -1400, -150, -1400} + ,{ 360, 360, -150, -150, -150} + ,{ -150, -890, -1400, -150, -1400} + } + ,{{ -150, -650, -1400, -150, -1400} + ,{ -150, -890, -1400, -150, -1400} + ,{ -150, -890, -1400, -150, -1400} + ,{ -150, -890, -1400, -150, -1400} + ,{ -650, -650, -1400, -1400, -1400} + } + } + ,{{{ 360, 360, -150, -1670, -150} + ,{ -30, -30, -1230, -1740, -1230} + ,{ -890, -890, -1400, -1670, -1400} + ,{ 360, 360, -150, -1910, -150} + ,{ -650, -650, -1400, -1670, -1400} + } + ,{{ -70, -70, -1400, -1910, -1400} + ,{ -70, -70, -1580, -2090, -1580} + ,{ -890, -890, -1400, -1910, -1400} + ,{ -910, -910, -1420, -1930, -1420} + ,{ -890, -890, -1400, -1910, -1400} + } + ,{{ -890, -890, -1400, -1670, -1400} + ,{ -890, -890, -1400, -1910, -1400} + ,{ -890, -890, -1400, -1670, -1400} + ,{ -890, -890, -1400, -1910, -1400} + ,{ -890, -890, -1400, -1670, -1400} + } + ,{{ 360, 360, -150, -1740, -150} + ,{ -30, -30, -1230, -1740, -1230} + ,{ -890, -890, -1400, -1910, -1400} + ,{ 360, 360, -150, -1910, -150} + ,{ -890, -890, -1400, -1910, -1400} + } + ,{{ -650, -650, -1400, -1670, -1400} + ,{ -890, -890, -1400, -1910, -1400} + ,{ -890, -890, -1400, -1670, -1400} + ,{ -890, -890, -1400, -1910, -1400} + ,{ -650, -650, -1400, -1910, -1400} + } + } + ,{{{ -150, -150, -150, -150, -150} + ,{ -990, -1230, -990, -1230, -990} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -150, -150, -150, -150, -150} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -1180, -1400, -1180, -1400, -1180} + ,{ -1580, -1580, -1580, -1580, -1580} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1180, -1420, -1180, -1420, -1180} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -150, -150, -150, -150, -150} + ,{ -990, -1230, -990, -1230, -990} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -150, -150, -150, -150, -150} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + } + } + ,{{{ -150, -1500, -150, -150, -150} + ,{ -150, -1570, -1230, -150, -1230} + ,{ -150, -1500, -1400, -150, -1400} + ,{ -150, -1740, -150, -150, -150} + ,{ -150, -1500, -1400, -150, -1400} + } + ,{{ -150, -1600, -1400, -150, -1400} + ,{ -330, -1600, -1580, -330, -1580} + ,{ -150, -1740, -1400, -150, -1400} + ,{ -1420, -3040, -1420, -1420, -1420} + ,{ -150, -1740, -1400, -150, -1400} + } + ,{{ -150, -1500, -1400, -150, -1400} + ,{ -150, -1740, -1400, -150, -1400} + ,{ -150, -1500, -1400, -150, -1400} + ,{ -150, -1740, -1400, -150, -1400} + ,{ -150, -1500, -1400, -150, -1400} + } + ,{{ -150, -1570, -150, -150, -150} + ,{ -1230, -1570, -1230, -1230, -1230} + ,{ -150, -1740, -1400, -150, -1400} + ,{ -150, -1740, -150, -1400, -150} + ,{ -150, -1740, -1400, -150, -1400} + } + ,{{ -150, -1500, -1400, -150, -1400} + ,{ -150, -1740, -1400, -150, -1400} + ,{ -150, -1500, -1400, -150, -1400} + ,{ -150, -1740, -1400, -150, -1400} + ,{ -1400, -1740, -1400, -1400, -1400} + } + } + ,{{{ -150, -150, -150, -150, -1230} + ,{ -990, -1230, -990, -1230, -1230} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -150, -150, -150, -150, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -1180, -1400, -1180, -1400, -1340} + ,{ -1340, -1580, -1580, -1580, -1340} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1180, -1420, -1180, -1420, -1420} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -150, -150, -150, -150, -1230} + ,{ -990, -1230, -990, -1230, -1230} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -150, -150, -150, -150, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + } + ,{{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + ,{ -1400, -1400, -1400, -1400, -1400} + } + } + } + ,{{{{ 910, 910, 400, 910, 400} + ,{ 910, 170, -340, 910, -100} + ,{ 400, -340, -850, 400, -850} + ,{ 910, 910, 400, 400, 400} + ,{ 400, -100, -850, 400, -850} + } + ,{{ 910, 170, -340, 910, -100} + ,{ 910, 170, -340, 910, -100} + ,{ 400, -340, -850, 400, -850} + ,{ -680, -680, -950, -1190, -950} + ,{ 400, -340, -850, 400, -850} + } + ,{{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + } + ,{{ 910, 910, 400, 400, 400} + ,{ -850, -850, -1120, -1360, -1120} + ,{ 400, -340, -850, 400, -850} + ,{ 910, 910, 400, 400, 400} + ,{ 400, -340, -850, 400, -850} + } + ,{{ 400, -100, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ 400, -340, -850, 400, -850} + ,{ -100, -100, -850, -850, -850} + } + } + ,{{{ 910, 910, 400, -850, 400} + ,{ 170, 170, -340, -850, -340} + ,{ -340, -340, -850, -1120, -850} + ,{ 910, 910, 400, -1360, 400} + ,{ -100, -100, -850, -1120, -850} + } + ,{{ 170, 170, -340, -850, -340} + ,{ 170, 170, -340, -850, -340} + ,{ -340, -340, -850, -1360, -850} + ,{ -680, -680, -1190, -1700, -1190} + ,{ -340, -340, -850, -1360, -850} + } + ,{{ -340, -340, -850, -1120, -850} + ,{ -340, -340, -850, -1360, -850} + ,{ -340, -340, -850, -1120, -850} + ,{ -340, -340, -850, -1360, -850} + ,{ -340, -340, -850, -1120, -850} + } + ,{{ 910, 910, 400, -1360, 400} + ,{ -850, -850, -1360, -1870, -1360} + ,{ -340, -340, -850, -1360, -850} + ,{ 910, 910, 400, -1360, 400} + ,{ -340, -340, -850, -1360, -850} + } + ,{{ -100, -100, -850, -1120, -850} + ,{ -340, -340, -850, -1360, -850} + ,{ -340, -340, -850, -1120, -850} + ,{ -340, -340, -850, -1360, -850} + ,{ -100, -100, -850, -1360, -850} + } + } + ,{{{ 400, 400, 400, 400, 400} + ,{ -340, -340, -340, -340, -340} + ,{ -850, -850, -850, -850, -850} + ,{ 400, 400, 400, 400, 400} + ,{ -850, -850, -850, -850, -850} + } + ,{{ -340, -340, -340, -340, -340} + ,{ -340, -340, -340, -340, -340} + ,{ -850, -850, -850, -850, -850} + ,{ -950, -1190, -950, -1190, -950} + ,{ -850, -850, -850, -850, -850} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + } + ,{{ 400, 400, 400, 400, 400} + ,{ -1120, -1360, -1120, -1360, -1120} + ,{ -850, -850, -850, -850, -850} + ,{ 400, 400, 400, 400, 400} + ,{ -850, -850, -850, -850, -850} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + } + } + ,{{{ 910, -680, 400, 910, 400} + ,{ 910, -680, -340, 910, -340} + ,{ 400, -950, -850, 400, -850} + ,{ 400, -1190, 400, 400, 400} + ,{ 400, -950, -850, 400, -850} + } + ,{{ 910, -680, -340, 910, -340} + ,{ 910, -680, -340, 910, -340} + ,{ 400, -1190, -850, 400, -850} + ,{ -1190, -1530, -1190, -1190, -1190} + ,{ 400, -1190, -850, 400, -850} + } + ,{{ 400, -950, -850, 400, -850} + ,{ 400, -1190, -850, 400, -850} + ,{ 400, -950, -850, 400, -850} + ,{ 400, -1190, -850, 400, -850} + ,{ 400, -950, -850, 400, -850} + } + ,{{ 400, -1190, 400, 400, 400} + ,{ -1360, -1700, -1360, -1360, -1360} + ,{ 400, -1190, -850, 400, -850} + ,{ 400, -1190, 400, -850, 400} + ,{ 400, -1190, -850, 400, -850} + } + ,{{ 400, -950, -850, 400, -850} + ,{ 400, -1190, -850, 400, -850} + ,{ 400, -950, -850, 400, -850} + ,{ 400, -1190, -850, 400, -850} + ,{ -850, -1190, -850, -850, -850} + } + } + ,{{{ 400, 400, 400, 400, -100} + ,{ -100, -340, -340, -340, -100} + ,{ -850, -850, -850, -850, -850} + ,{ 400, 400, 400, 400, -850} + ,{ -850, -850, -850, -850, -850} + } + ,{{ -100, -340, -340, -340, -100} + ,{ -100, -340, -340, -340, -100} + ,{ -850, -850, -850, -850, -850} + ,{ -950, -1190, -950, -1190, -1190} + ,{ -850, -850, -850, -850, -850} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + } + ,{{ 400, 400, 400, 400, -850} + ,{ -1120, -1360, -1120, -1360, -1360} + ,{ -850, -850, -850, -850, -850} + ,{ 400, 400, 400, 400, -850} + ,{ -850, -850, -850, -850, -850} + } + ,{{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + ,{ -850, -850, -850, -850, -850} + } + } + } + ,{{{{ 1490, 1280, 780, 1490, 780} + ,{ 1490, 750, 240, 1490, 480} + ,{ 1200, 450, -50, 1200, -50} + ,{ 1280, 1280, 780, 1200, 780} + ,{ 1200, 450, -50, 1200, -50} + } + ,{{ 1490, 750, 240, 1490, 480} + ,{ 1490, 750, 240, 1490, 480} + ,{ 1190, 440, -60, 1190, -60} + ,{ -630, -630, -900, -1140, -900} + ,{ 1190, 440, -60, 1190, -60} + } + ,{{ 1200, 460, -50, 1200, -50} + ,{ 1200, 460, -50, 1200, -50} + ,{ 1200, 450, -50, 1200, -50} + ,{ 1200, 460, -50, 1200, -50} + ,{ 1200, 450, -50, 1200, -50} + } + ,{{ 1280, 1280, 780, 1190, 780} + ,{ -450, -450, -720, -960, -720} + ,{ 1190, 440, -60, 1190, -60} + ,{ 1280, 1280, 780, 780, 780} + ,{ 1190, 440, -60, 1190, -60} + } + ,{{ 1200, 460, -50, 1200, -50} + ,{ 1200, 460, -50, 1200, -50} + ,{ 1200, 450, -50, 1200, -50} + ,{ 1200, 460, -50, 1200, -50} + ,{ -280, -280, -1030, -1030, -1030} + } + } + ,{{{ 1280, 1280, 780, -260, 780} + ,{ 750, 750, 240, -260, 240} + ,{ 450, 450, -50, -320, -50} + ,{ 1280, 1280, 780, -560, 780} + ,{ 450, 450, -50, -320, -50} + } + ,{{ 750, 750, 240, -260, 240} + ,{ 750, 750, 240, -260, 240} + ,{ 440, 440, -60, -570, -60} + ,{ -630, -630, -1140, -1650, -1140} + ,{ 440, 440, -60, -570, -60} + } + ,{{ 460, 460, -50, -320, -50} + ,{ 460, 460, -50, -560, -50} + ,{ 450, 450, -50, -320, -50} + ,{ 460, 460, -50, -560, -50} + ,{ 450, 450, -50, -320, -50} + } + ,{{ 1280, 1280, 780, -570, 780} + ,{ -450, -450, -960, -1470, -960} + ,{ 440, 440, -60, -570, -60} + ,{ 1280, 1280, 780, -980, 780} + ,{ 440, 440, -60, -570, -60} + } + ,{{ 460, 460, -50, -320, -50} + ,{ 460, 460, -50, -560, -50} + ,{ 450, 450, -50, -320, -50} + ,{ 460, 460, -50, -560, -50} + ,{ -280, -280, -1030, -1540, -1030} + } + } + ,{{{ 780, 780, 780, 780, 780} + ,{ 240, 240, 240, 240, 240} + ,{ -50, -50, -50, -50, -50} + ,{ 780, 780, 780, 780, 780} + ,{ -50, -50, -50, -50, -50} + } + ,{{ 240, 240, 240, 240, 240} + ,{ 240, 240, 240, 240, 240} + ,{ -60, -60, -60, -60, -60} + ,{ -900, -1140, -900, -1140, -900} + ,{ -60, -60, -60, -60, -60} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ 780, 780, 780, 780, 780} + ,{ -720, -960, -720, -960, -720} + ,{ -60, -60, -60, -60, -60} + ,{ 780, 780, 780, 780, 780} + ,{ -60, -60, -60, -60, -60} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -1030, -1030, -1030, -1030, -1030} + } + } + ,{{{ 1490, -90, 780, 1490, 780} + ,{ 1490, -90, 240, 1490, 240} + ,{ 1200, -150, -50, 1200, -50} + ,{ 1200, -390, 780, 1200, 780} + ,{ 1200, -150, -50, 1200, -50} + } + ,{{ 1490, -90, 240, 1490, 240} + ,{ 1490, -90, 240, 1490, 240} + ,{ 1190, -400, -60, 1190, -60} + ,{ -1140, -1480, -1140, -1140, -1140} + ,{ 1190, -400, -60, 1190, -60} + } + ,{{ 1200, -150, -50, 1200, -50} + ,{ 1200, -390, -50, 1200, -50} + ,{ 1200, -150, -50, 1200, -50} + ,{ 1200, -390, -50, 1200, -50} + ,{ 1200, -150, -50, 1200, -50} + } + ,{{ 1190, -400, 780, 1190, 780} + ,{ -960, -1300, -960, -960, -960} + ,{ 1190, -400, -60, 1190, -60} + ,{ 780, -810, 780, -470, 780} + ,{ 1190, -400, -60, 1190, -60} + } + ,{{ 1200, -150, -50, 1200, -50} + ,{ 1200, -390, -50, 1200, -50} + ,{ 1200, -150, -50, 1200, -50} + ,{ 1200, -390, -50, 1200, -50} + ,{ -1030, -1370, -1030, -1030, -1030} + } + } + ,{{{ 780, 780, 780, 780, 480} + ,{ 480, 240, 240, 240, 480} + ,{ -50, -50, -50, -50, -50} + ,{ 780, 780, 780, 780, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ 480, 240, 240, 240, 480} + ,{ 480, 240, 240, 240, 480} + ,{ -60, -60, -60, -60, -60} + ,{ -900, -1140, -900, -1140, -1140} + ,{ -60, -60, -60, -60, -60} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + } + ,{{ 780, 780, 780, 780, -60} + ,{ -720, -960, -720, -960, -960} + ,{ -60, -60, -60, -60, -60} + ,{ 780, 780, 780, 780, -470} + ,{ -60, -60, -60, -60, -60} + } + ,{{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -50, -50, -50, -50, -50} + ,{ -1030, -1030, -1030, -1030, -1030} + } + } + } + ,{{{{ 1560, 1470, 960, 1560, 960} + ,{ 1560, 820, 310, 1560, 550} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1470, 1470, 960, 1430, 960} + ,{ 1300, 560, 50, 1300, 50} + } + ,{{ 1560, 820, 310, 1560, 550} + ,{ 1560, 820, 310, 1560, 550} + ,{ 1280, 540, 30, 1280, 30} + ,{ -580, -580, -850, -1090, -850} + ,{ 1280, 540, 30, 1280, 30} + } + ,{{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1300, 560, 50, 1300, 50} + } + ,{{ 1470, 1470, 960, 1280, 960} + ,{ -880, -880, -1150, -1390, -1150} + ,{ 1280, 540, 30, 1280, 30} + ,{ 1470, 1470, 960, 960, 960} + ,{ 1280, 540, 30, 1280, 30} + } + ,{{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 990, 250, -260, 990, -260} + ,{ 1430, 690, 180, 1430, 180} + ,{ -10, -10, -760, -760, -760} + } + } + ,{{{ 1470, 1470, 960, -90, 960} + ,{ 820, 820, 310, -200, 310} + ,{ 690, 690, 180, -90, 180} + ,{ 1470, 1470, 960, -330, 960} + ,{ 560, 560, 50, -220, 50} + } + ,{{ 820, 820, 310, -200, 310} + ,{ 820, 820, 310, -200, 310} + ,{ 540, 540, 30, -480, 30} + ,{ -580, -580, -1090, -1600, -1090} + ,{ 540, 540, 30, -480, 30} + } + ,{{ 690, 690, 180, -90, 180} + ,{ 690, 690, 180, -330, 180} + ,{ 690, 690, 180, -90, 180} + ,{ 690, 690, 180, -330, 180} + ,{ 560, 560, 50, -220, 50} + } + ,{{ 1470, 1470, 960, -480, 960} + ,{ -880, -880, -1390, -1900, -1390} + ,{ 540, 540, 30, -480, 30} + ,{ 1470, 1470, 960, -800, 960} + ,{ 540, 540, 30, -480, 30} + } + ,{{ 690, 690, 180, -330, 180} + ,{ 690, 690, 180, -330, 180} + ,{ 250, 250, -260, -530, -260} + ,{ 690, 690, 180, -330, 180} + ,{ -10, -10, -760, -1270, -760} + } + } + ,{{{ 960, 960, 960, 960, 960} + ,{ 310, 310, 310, 310, 310} + ,{ 180, 180, 180, 180, 180} + ,{ 960, 960, 960, 960, 960} + ,{ 50, 50, 50, 50, 50} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 30, 30, 30, 30, 30} + ,{ -850, -1090, -850, -1090, -850} + ,{ 30, 30, 30, 30, 30} + } + ,{{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 50, 50, 50, 50, 50} + } + ,{{ 960, 960, 960, 960, 960} + ,{ -1150, -1390, -1150, -1390, -1150} + ,{ 30, 30, 30, 30, 30} + ,{ 960, 960, 960, 960, 960} + ,{ 30, 30, 30, 30, 30} + } + ,{{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ -260, -260, -260, -260, -260} + ,{ 180, 180, 180, 180, 180} + ,{ -760, -760, -760, -760, -760} + } + } + ,{{{ 1560, 80, 960, 1560, 960} + ,{ 1560, -30, 310, 1560, 310} + ,{ 1430, 80, 180, 1430, 180} + ,{ 1430, -160, 960, 1430, 960} + ,{ 1300, -50, 50, 1300, 50} + } + ,{{ 1560, -30, 310, 1560, 310} + ,{ 1560, -30, 310, 1560, 310} + ,{ 1280, -310, 30, 1280, 30} + ,{ -1090, -1430, -1090, -1090, -1090} + ,{ 1280, -310, 30, 1280, 30} + } + ,{{ 1430, 80, 180, 1430, 180} + ,{ 1430, -160, 180, 1430, 180} + ,{ 1430, 80, 180, 1430, 180} + ,{ 1430, -160, 180, 1430, 180} + ,{ 1300, -50, 50, 1300, 50} + } + ,{{ 1280, -310, 960, 1280, 960} + ,{ -1390, -1730, -1390, -1390, -1390} + ,{ 1280, -310, 30, 1280, 30} + ,{ 960, -630, 960, -290, 960} + ,{ 1280, -310, 30, 1280, 30} + } + ,{{ 1430, -160, 180, 1430, 180} + ,{ 1430, -160, 180, 1430, 180} + ,{ 990, -360, -260, 990, -260} + ,{ 1430, -160, 180, 1430, 180} + ,{ -760, -1100, -760, -760, -760} + } + } + ,{{{ 960, 960, 960, 960, 550} + ,{ 550, 310, 310, 310, 550} + ,{ 180, 180, 180, 180, 180} + ,{ 960, 960, 960, 960, 180} + ,{ 50, 50, 50, 50, 50} + } + ,{{ 550, 310, 310, 310, 550} + ,{ 550, 310, 310, 310, 550} + ,{ 30, 30, 30, 30, 30} + ,{ -850, -1090, -850, -1090, -1090} + ,{ 30, 30, 30, 30, 30} + } + ,{{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 50, 50, 50, 50, 50} + } + ,{{ 960, 960, 960, 960, 30} + ,{ -1150, -1390, -1150, -1390, -1390} + ,{ 30, 30, 30, 30, 30} + ,{ 960, 960, 960, 960, -290} + ,{ 30, 30, 30, 30, 30} + } + ,{{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ -260, -260, -260, -260, -260} + ,{ 180, 180, 180, 180, 180} + ,{ -760, -760, -760, -760, -760} + } + } + } + ,{{{{ 1560, 1470, 960, 1560, 960} + ,{ 1560, 820, 310, 1560, 550} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1470, 1470, 960, 1430, 960} + ,{ 1300, 560, 50, 1300, 50} + } + ,{{ 1560, 820, 310, 1560, 550} + ,{ 1560, 820, 310, 1560, 550} + ,{ 1280, 540, 30, 1280, 30} + ,{ -360, -360, -630, -870, -630} + ,{ 1280, 540, 30, 1280, 30} + } + ,{{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1300, 560, 50, 1300, 50} + } + ,{{ 1470, 1470, 960, 1280, 960} + ,{ -30, -30, -720, -960, -720} + ,{ 1280, 540, 30, 1280, 30} + ,{ 1470, 1470, 960, 960, 960} + ,{ 1280, 540, 30, 1280, 30} + } + ,{{ 1430, 690, 180, 1430, 180} + ,{ 1430, 690, 180, 1430, 180} + ,{ 1200, 450, -50, 1200, -50} + ,{ 1430, 690, 180, 1430, 180} + ,{ -10, -10, -760, -760, -760} + } + } + ,{{{ 1470, 1470, 960, -90, 960} + ,{ 820, 820, 310, -200, 310} + ,{ 690, 690, 180, -90, 180} + ,{ 1470, 1470, 960, -330, 960} + ,{ 560, 560, 50, -220, 50} + } + ,{{ 820, 820, 310, -200, 310} + ,{ 820, 820, 310, -200, 310} + ,{ 540, 540, 30, -480, 30} + ,{ -360, -360, -870, -1380, -870} + ,{ 540, 540, 30, -480, 30} + } + ,{{ 690, 690, 180, -90, 180} + ,{ 690, 690, 180, -330, 180} + ,{ 690, 690, 180, -90, 180} + ,{ 690, 690, 180, -330, 180} + ,{ 560, 560, 50, -220, 50} + } + ,{{ 1470, 1470, 960, -480, 960} + ,{ -30, -30, -960, -1470, -960} + ,{ 540, 540, 30, -480, 30} + ,{ 1470, 1470, 960, -800, 960} + ,{ 540, 540, 30, -480, 30} + } + ,{{ 690, 690, 180, -320, 180} + ,{ 690, 690, 180, -330, 180} + ,{ 450, 450, -50, -320, -50} + ,{ 690, 690, 180, -330, 180} + ,{ -10, -10, -760, -1270, -760} + } + } + ,{{{ 960, 960, 960, 960, 960} + ,{ 310, 310, 310, 310, 310} + ,{ 180, 180, 180, 180, 180} + ,{ 960, 960, 960, 960, 960} + ,{ 50, 50, 50, 50, 50} + } + ,{{ 310, 310, 310, 310, 310} + ,{ 310, 310, 310, 310, 310} + ,{ 30, 30, 30, 30, 30} + ,{ -630, -870, -630, -870, -630} + ,{ 30, 30, 30, 30, 30} + } + ,{{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ 50, 50, 50, 50, 50} + } + ,{{ 960, 960, 960, 960, 960} + ,{ -720, -960, -720, -960, -720} + ,{ 30, 30, 30, 30, 30} + ,{ 960, 960, 960, 960, 960} + ,{ 30, 30, 30, 30, 30} + } + ,{{ 180, 180, 180, 180, 180} + ,{ 180, 180, 180, 180, 180} + ,{ -50, -50, -50, -50, -50} + ,{ 180, 180, 180, 180, 180} + ,{ -760, -760, -760, -760, -760} + } + } + ,{{{ 1560, 80, 960, 1560, 960} + ,{ 1560, -30, 310, 1560, 310} + ,{ 1430, 80, 180, 1430, 180} + ,{ 1430, -160, 960, 1430, 960} + ,{ 1300, -50, 50, 1300, 50} + } + ,{{ 1560, -30, 310, 1560, 310} + ,{ 1560, -30, 310, 1560, 310} + ,{ 1280, -310, 30, 1280, 30} + ,{ -870, -1210, -870, -870, -870} + ,{ 1280, -310, 30, 1280, 30} + } + ,{{ 1430, 80, 180, 1430, 180} + ,{ 1430, -160, 180, 1430, 180} + ,{ 1430, 80, 180, 1430, 180} + ,{ 1430, -160, 180, 1430, 180} + ,{ 1300, -50, 50, 1300, 50} + } + ,{{ 1280, -310, 960, 1280, 960} + ,{ -960, -1300, -960, -960, -960} + ,{ 1280, -310, 30, 1280, 30} + ,{ 960, -630, 960, -290, 960} + ,{ 1280, -310, 30, 1280, 30} + } + ,{{ 1430, -150, 180, 1430, 180} + ,{ 1430, -160, 180, 1430, 180} + ,{ 1200, -150, -50, 1200, -50} + ,{ 1430, -160, 180, 1430, 180} + ,{ -760, -1100, -760, -760, -760} + } + } + ,{{{ 960, 960, 960, 960, 550} + ,{ 550, 310, 310, 310, 550} + ,{ 180, 180, 180, 180, 180} + ,{ 960, 960, 960, 960, 180} + ,{ 50, 50, 50, 50, 50} + } + ,{{ 550, 310, 310, 310, 550} + ,{ 550, 310, 310, 310, 550} + ,{ 30, 30, 30, 30, 30} + ,{ -630, -870, -630, -870, -870} + ,{ 30, 30, 30, 30, 30} 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-150, -140, -150, -1120} + ,{ 480, 470, 480, 470, -1040} + ,{ -140, -150, -140, -150, -1120} + } + ,{{ 300, 290, 300, 290, -430} + ,{ 300, 290, 300, 290, -430} + ,{ -140, -150, -140, -150, -1120} + ,{ -640, -890, -640, -890, -1860} + ,{ -140, -150, -140, -150, -1120} + } + ,{{ -60, -70, -60, -70, -1040} + ,{ -60, -70, -60, -70, -1040} + ,{ -360, -370, -360, -370, -1340} + ,{ -60, -70, -60, -70, -1040} + ,{ -360, -370, -360, -370, -1340} + } + ,{{ 480, 470, 480, 470, -1120} + ,{ -170, -420, -170, -420, -1390} + ,{ -140, -150, -140, -150, -1120} + ,{ 480, 470, 480, 470, -1750} + ,{ -140, -150, -140, -150, -1120} + } + ,{{ -60, -70, -60, -70, -1040} + ,{ -60, -70, -60, -70, -1040} + ,{ -670, -680, -670, -680, -1650} + ,{ -60, -70, -60, -70, -1040} + ,{ -350, -360, -350, -360, -1330} + } + } + } + ,{{{{ 940, 940, 650, 630, 650} + ,{ 220, -130, -190, 220, -190} + ,{ 220, -310, -600, 220, -600} + ,{ 940, 940, 650, 630, 650} + ,{ 220, -70, -600, 220, -600} + } + ,{{ 220, -310, -380, 220, -380} + ,{ 40, -490, -780, 40, -780} + ,{ 220, -310, -600, 220, -600} + ,{ -320, -320, -380, -630, -380} + ,{ 220, -310, -600, 220, -600} + } + ,{{ 220, -310, -600, 220, -600} + ,{ 220, -310, -600, 220, -600} + ,{ 220, -310, -600, 220, -600} + ,{ 220, -310, -600, 220, -600} + ,{ 220, -310, -600, 220, -600} + } + ,{{ 940, 940, 650, 630, 650} + ,{ -130, -130, -190, -440, -190} + ,{ 220, -310, -600, 220, -600} + ,{ 940, 940, 650, 630, 650} + ,{ 220, -310, -600, 220, -600} + } + ,{{ 220, -70, -600, 220, -600} + ,{ 220, -310, -600, 220, -600} + ,{ 220, -310, -600, 220, -600} + ,{ 220, -310, -600, 220, -600} + ,{ -70, -70, -600, -620, -600} + } + } + ,{{{ 940, 940, 650, -1280, 650} + ,{ -130, -130, -430, -1340, -430} + ,{ -310, -310, -600, -1280, -600} + ,{ 940, 940, 650, -1520, 650} + ,{ -70, -70, -600, -1280, -600} + } + ,{{ -310, -310, -600, -1520, -600} + ,{ -490, -490, -780, -1700, -780} + ,{ -310, -310, -600, -1520, -600} + ,{ -320, -320, -620, -1530, -620} + ,{ -310, -310, -600, -1520, -600} + } + ,{{ -310, -310, -600, -1280, -600} + ,{ -310, -310, -600, -1520, -600} + ,{ -310, -310, -600, -1280, -600} + ,{ -310, -310, -600, -1520, -600} + ,{ -310, -310, -600, -1280, -600} + } + ,{{ 940, 940, 650, -1340, 650} + ,{ -130, -130, -430, -1340, -430} + ,{ -310, -310, -600, -1520, -600} + ,{ 940, 940, 650, -1520, 650} + ,{ -310, -310, -600, -1520, -600} + } + ,{{ -70, -70, -600, -1280, -600} + ,{ -310, -310, -600, -1520, -600} + ,{ -310, -310, -600, -1280, -600} + ,{ -310, -310, -600, -1520, -600} + ,{ -70, -70, -600, -1520, -600} + } + } + ,{{{ 640, 630, 640, 630, 640} + ,{ -190, -440, -190, -440, -190} + ,{ -610, -620, -610, -620, -610} + ,{ 640, 630, 640, 630, 640} + ,{ -610, -620, -610, -620, -610} + } + ,{{ -380, -620, -380, -620, -380} + ,{ -790, -800, -790, -800, -790} + ,{ -610, -620, -610, -620, -610} + ,{ -380, -630, -380, -630, -380} + ,{ -610, -620, -610, -620, -610} + } + ,{{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + } + ,{{ 640, 630, 640, 630, 640} + ,{ -190, -440, -190, -440, -190} + ,{ -610, -620, -610, -620, -610} + ,{ 640, 630, 640, 630, 640} + ,{ -610, -620, -610, -620, -610} + } + ,{{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + ,{ -610, -620, -610, -620, -610} + } + } + ,{{{ 650, -1460, 650, 220, 650} + ,{ 220, -1520, -430, 220, -430} + ,{ 220, -1460, -600, 220, -600} + ,{ 650, -1700, 650, 220, 650} + ,{ 220, -1460, -600, 220, -600} + } + ,{{ 220, -1700, -600, 220, -600} + ,{ 40, -1880, -780, 40, -780} + ,{ 220, -1700, -600, 220, -600} + ,{ -620, -1710, -620, -1040, -620} + ,{ 220, -1700, -600, 220, -600} + } + ,{{ 220, -1460, -600, 220, -600} + ,{ 220, -1700, -600, 220, -600} + ,{ 220, -1460, -600, 220, -600} + ,{ 220, -1700, -600, 220, -600} + ,{ 220, -1460, -600, 220, -600} + } + ,{{ 650, -1520, 650, 220, 650} + ,{ -430, -1520, -430, -850, -430} + ,{ 220, -1700, -600, 220, -600} + ,{ 650, -1700, 650, -1030, 650} + ,{ 220, -1700, -600, 220, -600} + } + ,{{ 220, -1460, -600, 220, -600} + ,{ 220, -1700, -600, 220, -600} + ,{ 220, -1460, -600, 220, -600} + ,{ 220, -1700, -600, 220, -600} + ,{ -600, -1700, -600, -1030, -600} + } + } + ,{{{ 640, 630, 640, 630, -1410} + ,{ -190, -440, -190, -440, -1410} + ,{ -610, -620, -610, -620, -1590} + ,{ 640, 630, 640, 630, -1590} + ,{ -610, -620, -610, -620, -1590} + } + ,{{ -380, -620, -380, -620, -1530} + ,{ -790, -800, -790, -800, -1530} + ,{ -610, -620, -610, -620, -1590} + ,{ -380, -630, -380, -630, -1600} + ,{ -610, -620, -610, -620, -1590} + } + ,{{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + } + ,{{ 640, 630, 640, 630, -1410} + ,{ -190, -440, -190, -440, -1410} + ,{ -610, -620, -610, -620, -1590} + ,{ 640, 630, 640, 630, -1590} + ,{ -610, -620, -610, -620, -1590} + } + ,{{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + ,{ -610, -620, -610, -620, -1590} + } + } + } + ,{{{{ 1490, 1490, 1200, 1280, 1200} + ,{ 1280, 750, 460, 1280, 460} + ,{ 780, 240, -50, 780, -50} + ,{ 1490, 1490, 1200, 1190, 1200} + ,{ 780, 480, -50, 780, -50} + } + ,{{ 1280, 750, 460, 1280, 460} + ,{ 1280, 750, 460, 1280, 460} + ,{ 780, 240, -50, 780, -50} + ,{ -90, -90, -150, -400, -150} + ,{ 780, 240, -50, 780, -50} + } + ,{{ 780, 240, -50, 780, -50} + ,{ 780, 240, -50, 780, -50} + ,{ 780, 240, -50, 780, -50} + ,{ 780, 240, -50, 780, -50} + ,{ 780, 240, -50, 780, -50} + } + ,{{ 1490, 1490, 1200, 1190, 1200} + ,{ -260, -260, -320, -570, -320} + ,{ 780, 240, -50, 780, -50} + ,{ 1490, 1490, 1200, 1190, 1200} + ,{ 780, 240, -50, 780, -50} + } + ,{{ 780, 480, -50, 780, -50} + ,{ 780, 240, -50, 780, -50} + ,{ 780, 240, -50, 780, -50} + ,{ 780, 240, -50, 780, -50} + ,{ 480, 480, -50, -60, -50} + } + } + ,{{{ 1490, 1490, 1200, -450, 1200} + ,{ 750, 750, 460, -450, 460} + ,{ 240, 240, -50, -720, -50} + ,{ 1490, 1490, 1200, -960, 1200} + ,{ 480, 480, -50, -720, -50} + } + ,{{ 750, 750, 460, -450, 460} + ,{ 750, 750, 460, -450, 460} + ,{ 240, 240, -50, -960, -50} + ,{ -90, -90, -390, -1300, -390} + ,{ 240, 240, -50, -960, -50} + } + ,{{ 240, 240, -50, -720, -50} + ,{ 240, 240, -50, -960, -50} + ,{ 240, 240, -50, -720, -50} + ,{ 240, 240, -50, -960, -50} + ,{ 240, 240, -50, -720, -50} + } + ,{{ 1490, 1490, 1200, -960, 1200} + ,{ -260, -260, -560, -1470, -560} + ,{ 240, 240, -50, -960, -50} + ,{ 1490, 1490, 1200, -960, 1200} + ,{ 240, 240, -50, -960, -50} + } + ,{{ 480, 480, -50, -720, -50} + ,{ 240, 240, -50, -960, -50} + ,{ 240, 240, -50, -720, -50} + ,{ 240, 240, -50, -960, -50} + ,{ 480, 480, -50, -960, -50} + } + } + ,{{{ 1200, 1190, 1200, 1190, 1200} + ,{ 450, 440, 450, 440, 450} + ,{ -50, -60, -50, -60, -50} + ,{ 1200, 1190, 1200, 1190, 1200} + ,{ -50, -60, -50, -60, -50} + } + ,{{ 450, 440, 450, 440, 450} + ,{ 450, 440, 450, 440, 450} + ,{ -50, -60, -50, -60, -50} + ,{ -150, -400, -150, -400, -150} + ,{ -50, -60, -50, -60, -50} + } + ,{{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + } + ,{{ 1200, 1190, 1200, 1190, 1200} + ,{ -320, -570, -320, -570, -320} + ,{ -50, -60, -50, -60, -50} + ,{ 1200, 1190, 1200, 1190, 1200} + ,{ -50, -60, -50, -60, -50} + } + ,{{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + ,{ -50, -60, -50, -60, -50} + } + } + ,{{{ 1280, -630, 1200, 1280, 1200} + ,{ 1280, -630, 460, 1280, 460} + ,{ 780, -900, -50, 780, -50} + ,{ 1200, -1140, 1200, 780, 1200} + ,{ 780, -900, -50, 780, -50} + } + ,{{ 1280, -630, 460, 1280, 460} + ,{ 1280, -630, 460, 1280, 460} + ,{ 780, -1140, -50, 780, -50} + ,{ -390, -1480, -390, -810, -390} + ,{ 780, -1140, -50, 780, -50} + } + ,{{ 780, -900, -50, 780, -50} + ,{ 780, -1140, -50, 780, -50} + ,{ 780, -900, -50, 780, -50} + ,{ 780, -1140, -50, 780, -50} + ,{ 780, -900, -50, 780, -50} + } + ,{{ 1200, -1140, 1200, 780, 1200} + ,{ -560, -1650, -560, -980, -560} + ,{ 780, -1140, -50, 780, -50} + ,{ 1200, -1140, 1200, -470, 1200} + ,{ 780, -1140, -50, 780, -50} + } + ,{{ 780, -900, -50, 780, -50} + ,{ 780, -1140, -50, 780, -50} + ,{ 780, -900, -50, 780, -50} + ,{ 780, -1140, -50, 780, -50} + ,{ -50, -1140, -50, -470, -50} + } + } + ,{{{ 1200, 1190, 1200, 1190, -280} + ,{ 450, 440, 450, 440, -280} + ,{ -50, -60, -50, -60, -1030} + ,{ 1200, 1190, 1200, 1190, -1030} + ,{ -50, -60, -50, -60, -1030} + } + ,{{ 450, 440, 450, 440, -280} + ,{ 450, 440, 450, 440, -280} + ,{ -50, -60, -50, -60, -1030} + ,{ -150, -400, -150, -400, -1370} + ,{ -50, -60, -50, -60, -1030} + } + ,{{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + } + ,{{ 1200, 1190, 1200, 1190, -1030} + ,{ -320, -570, -320, -570, -1540} + ,{ -50, -60, -50, -60, -1030} + ,{ 1200, 1190, 1200, 1190, -1030} + ,{ -50, -60, -50, -60, -1030} + } + ,{{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + ,{ -50, -60, -50, -60, -1030} + } + } + } + ,{{{{ 1870, 1870, 1570, 1870, 1570} + ,{ 1870, 1340, 1040, 1870, 1040} + ,{ 1570, 1040, 740, 1570, 740} + ,{ 1870, 1870, 1570, 1570, 1570} + ,{ 1570, 1040, 740, 1570, 740} + } + ,{{ 1870, 1340, 1040, 1870, 1040} + ,{ 1870, 1340, 1040, 1870, 1040} + ,{ 1560, 1030, 730, 1560, 730} + ,{ -50, -50, -110, -360, -110} + ,{ 1560, 1030, 730, 1560, 730} + } + ,{{ 1570, 1040, 750, 1570, 750} + ,{ 1570, 1040, 750, 1570, 750} + ,{ 1570, 1040, 740, 1570, 740} + ,{ 1570, 1040, 750, 1570, 750} + ,{ 1570, 1040, 740, 1570, 740} + } + ,{{ 1870, 1870, 1570, 1560, 1570} + ,{ 130, 130, 70, -180, 70} + ,{ 1560, 1030, 730, 1560, 730} + ,{ 1870, 1870, 1570, 1560, 1570} + ,{ 1560, 1030, 730, 1560, 730} + } + ,{{ 1570, 1040, 750, 1570, 750} + ,{ 1570, 1040, 750, 1570, 750} + ,{ 1570, 1040, 740, 1570, 740} + ,{ 1570, 1040, 750, 1570, 750} + ,{ 300, 300, -230, -250, -230} + } + } + ,{{{ 1870, 1870, 1570, 130, 1570} + ,{ 1340, 1340, 1040, 130, 1040} + ,{ 1040, 1040, 740, 70, 740} + ,{ 1870, 1870, 1570, -160, 1570} + ,{ 1040, 1040, 740, 70, 740} + } + ,{{ 1340, 1340, 1040, 130, 1040} + ,{ 1340, 1340, 1040, 130, 1040} + ,{ 1030, 1030, 730, -180, 730} + ,{ -50, -50, -340, -1260, -340} + ,{ 1030, 1030, 730, -180, 730} + } + ,{{ 1040, 1040, 750, 70, 750} + ,{ 1040, 1040, 750, -160, 750} + ,{ 1040, 1040, 740, 70, 740} + ,{ 1040, 1040, 750, -160, 750} + ,{ 1040, 1040, 740, 70, 740} + } + ,{{ 1870, 1870, 1570, -180, 1570} + ,{ 130, 130, -160, -1080, -160} + ,{ 1030, 1030, 730, -180, 730} + ,{ 1870, 1870, 1570, -590, 1570} + ,{ 1030, 1030, 730, -180, 730} + } + ,{{ 1040, 1040, 750, 70, 750} + ,{ 1040, 1040, 750, -160, 750} + ,{ 1040, 1040, 740, 70, 740} + ,{ 1040, 1040, 750, -160, 750} + ,{ 300, 300, -230, -1150, -230} + } + } + ,{{{ 1570, 1560, 1570, 1560, 1570} + ,{ 1040, 1030, 1040, 1030, 1040} + ,{ 740, 730, 740, 730, 740} + ,{ 1570, 1560, 1570, 1560, 1570} + ,{ 740, 730, 740, 730, 740} + } + ,{{ 1040, 1030, 1040, 1030, 1040} + ,{ 1040, 1030, 1040, 1030, 1040} + ,{ 730, 720, 730, 720, 730} + ,{ -110, -360, -110, -360, -110} + ,{ 730, 720, 730, 720, 730} + } + ,{{ 740, 730, 740, 730, 740} + ,{ 740, 730, 740, 730, 740} + ,{ 740, 730, 740, 730, 740} + ,{ 740, 730, 740, 730, 740} + ,{ 740, 730, 740, 730, 740} + } + ,{{ 1570, 1560, 1570, 1560, 1570} + ,{ 70, -180, 70, -180, 70} + ,{ 730, 720, 730, 720, 730} + ,{ 1570, 1560, 1570, 1560, 1570} + ,{ 730, 720, 730, 720, 730} + } + ,{{ 740, 730, 740, 730, 740} + ,{ 740, 730, 740, 730, 740} + ,{ 740, 730, 740, 730, 740} + ,{ 740, 730, 740, 730, 740} + ,{ -240, -250, -240, -250, -240} + } + } + ,{{{ 1870, -50, 1570, 1870, 1570} + ,{ 1870, -50, 1040, 1870, 1040} + ,{ 1570, -110, 740, 1570, 740} + ,{ 1570, -340, 1570, 1570, 1570} + ,{ 1570, -110, 740, 1570, 740} + } + ,{{ 1870, -50, 1040, 1870, 1040} + ,{ 1870, -50, 1040, 1870, 1040} + ,{ 1560, -360, 730, 1560, 730} + ,{ -340, -1440, -340, -770, -340} + ,{ 1560, -360, 730, 1560, 730} + } + ,{{ 1570, -110, 750, 1570, 750} + ,{ 1570, -340, 750, 1570, 750} + ,{ 1570, -110, 740, 1570, 740} + ,{ 1570, -340, 750, 1570, 750} + ,{ 1570, -110, 740, 1570, 740} + } + ,{{ 1570, -360, 1570, 1560, 1570} + ,{ -160, -1260, -160, -590, -160} + ,{ 1560, -360, 730, 1560, 730} + ,{ 1570, -770, 1570, -100, 1570} + ,{ 1560, -360, 730, 1560, 730} + } + ,{{ 1570, -110, 750, 1570, 750} + ,{ 1570, -340, 750, 1570, 750} + ,{ 1570, -110, 740, 1570, 740} + ,{ 1570, -340, 750, 1570, 750} + ,{ -230, -1330, -230, -660, -230} + } + } + ,{{{ 1570, 1560, 1570, 1560, 300} + ,{ 1040, 1030, 1040, 1030, 300} + ,{ 740, 730, 740, 730, -240} + ,{ 1570, 1560, 1570, 1560, -230} + ,{ 740, 730, 740, 730, -240} + } + ,{{ 1040, 1030, 1040, 1030, 300} + ,{ 1040, 1030, 1040, 1030, 300} + ,{ 730, 720, 730, 720, -250} + ,{ -110, -360, -110, -360, -1330} + ,{ 730, 720, 730, 720, -250} + } + ,{{ 740, 730, 740, 730, -230} + ,{ 740, 730, 740, 730, -230} + ,{ 740, 730, 740, 730, -240} + ,{ 740, 730, 740, 730, -230} + ,{ 740, 730, 740, 730, -240} + } + ,{{ 1570, 1560, 1570, 1560, -250} + ,{ 70, -180, 70, -180, -1150} + ,{ 730, 720, 730, 720, -250} + ,{ 1570, 1560, 1570, 1560, -660} + ,{ 730, 720, 730, 720, -250} + } + ,{{ 740, 730, 740, 730, -230} + ,{ 740, 730, 740, 730, -230} + ,{ 740, 730, 740, 730, -240} + ,{ 740, 730, 740, 730, -230} + ,{ -240, -250, -240, -250, -1220} + } + } + } + ,{{{{ 2050, 2050, 1760, 1930, 1760} + ,{ 1930, 1400, 1110, 1930, 1110} + ,{ 1800, 1270, 980, 1800, 980} + ,{ 2050, 2050, 1760, 1800, 1760} + ,{ 1670, 1140, 850, 1670, 850} + } + ,{{ 1930, 1400, 1110, 1930, 1110} + ,{ 1930, 1400, 1110, 1930, 1110} + ,{ 1650, 1120, 830, 1650, 830} + ,{ 0, 0, -60, -310, -60} + ,{ 1650, 1120, 830, 1650, 830} + } + ,{{ 1800, 1270, 980, 1800, 980} + ,{ 1800, 1270, 980, 1800, 980} + ,{ 1800, 1270, 980, 1800, 980} + ,{ 1800, 1270, 980, 1800, 980} + ,{ 1670, 1140, 850, 1670, 850} + } + ,{{ 2050, 2050, 1760, 1740, 1760} + ,{ -300, -300, -360, -610, -360} + ,{ 1650, 1120, 830, 1650, 830} + ,{ 2050, 2050, 1760, 1740, 1760} + ,{ 1650, 1120, 830, 1650, 830} + } + ,{{ 1800, 1270, 980, 1800, 980} + ,{ 1800, 1270, 980, 1800, 980} + ,{ 1360, 830, 540, 1360, 540} + ,{ 1800, 1270, 980, 1800, 980} + ,{ 570, 570, 40, 20, 40} + } + } + ,{{{ 2050, 2050, 1760, 300, 1760} + ,{ 1400, 1400, 1110, 190, 1110} + ,{ 1270, 1270, 980, 300, 980} + ,{ 2050, 2050, 1760, 60, 1760} + ,{ 1140, 1140, 850, 180, 850} + } + ,{{ 1400, 1400, 1110, 190, 1110} + ,{ 1400, 1400, 1110, 190, 1110} + ,{ 1120, 1120, 830, -80, 830} + ,{ 0, 0, -290, -1210, -290} + ,{ 1120, 1120, 830, -80, 830} + } + ,{{ 1270, 1270, 980, 300, 980} + ,{ 1270, 1270, 980, 60, 980} + ,{ 1270, 1270, 980, 300, 980} + ,{ 1270, 1270, 980, 60, 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INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + } + ,{{{{ 1350, 850, 720, 1350, 720} + ,{ 1300, 650, 520, 1300, 520} + ,{ 1350, 700, 570, 1350, 570} + ,{ 1300, 850, 720, 1300, 720} + ,{ 1250, 590, 460, 1250, 460} + } + ,{{ 1160, 500, 400, 1160, 370} + ,{ 1160, 500, 370, 1160, 370} + ,{ 850, 190, 60, 850, 60} + ,{ 400, 290, 400, 10, 160} + ,{ 850, 190, 60, 850, 60} + } + ,{{ 1300, 650, 520, 1300, 520} + ,{ 1300, 650, 520, 1300, 520} + ,{ 1290, 640, 510, 1290, 510} + ,{ 1300, 650, 520, 1300, 520} + ,{ 1250, 590, 460, 1250, 460} + } + ,{{ 850, 850, 720, 850, 720} + ,{ 120, 0, 120, -270, -120} + ,{ 850, 190, 60, 850, 60} + ,{ 850, 850, 720, 570, 720} + ,{ 850, 190, 60, 850, 60} + } + ,{{ 1350, 700, 570, 1350, 570} + ,{ 1300, 650, 520, 1300, 520} + ,{ 1350, 700, 570, 1350, 570} + ,{ 1300, 650, 520, 1300, 520} + ,{ 100, 100, -270, -420, -270} + } + } + ,{{{ 850, 850, 720, -760, 720} + ,{ 650, 650, 520, -1050, 520} + ,{ 700, 700, 570, -760, 570} + ,{ 850, 850, 720, -1050, 720} + ,{ 590, 590, 460, -870, 460} + } + ,{{ 500, 500, 370, -1200, 370} + ,{ 500, 500, 370, -1200, 370} + ,{ 190, 190, 60, -1510, 60} + ,{ 290, 290, 160, -1410, 160} + ,{ 190, 190, 60, -1510, 60} + } + ,{{ 650, 650, 520, -820, 520} + ,{ 650, 650, 520, -1050, 520} + ,{ 640, 640, 510, -820, 510} + ,{ 650, 650, 520, -1050, 520} + ,{ 590, 590, 460, -870, 460} + } + ,{{ 850, 850, 720, -1510, 720} + ,{ 0, 0, -120, -1700, -120} + ,{ 190, 190, 60, -1510, 60} + ,{ 850, 850, 720, -2110, 720} + ,{ 190, 190, 60, -1510, 60} + } + ,{{ 700, 700, 570, -760, 570} + ,{ 650, 650, 520, -1050, 520} + ,{ 700, 700, 570, -760, 570} + ,{ 650, 650, 520, -1050, 520} + ,{ 100, 100, -270, -1840, -270} + } + } + ,{{{ 720, 570, 720, 570, 280} + ,{ 520, 370, 520, 370, 80} + ,{ 570, 420, 570, 420, 130} + ,{ 720, 570, 720, 570, 280} + ,{ 460, 310, 460, 310, 20} + } + ,{{ 400, 220, 400, 220, -40} + ,{ 370, 220, 370, 220, -60} + ,{ 60, -80, 60, -80, -370} + ,{ 400, 10, 400, 10, -40} + ,{ 60, -80, 60, -80, -370} + } + ,{{ 520, 370, 520, 370, 80} + ,{ 520, 370, 520, 370, 80} + ,{ 510, 360, 510, 360, 70} + ,{ 520, 370, 520, 370, 80} + ,{ 460, 310, 460, 310, 20} + } + ,{{ 720, 570, 720, 570, 280} + ,{ 120, -270, 120, -270, -320} + ,{ 60, -80, 60, -80, -370} + ,{ 720, 570, 720, 570, 280} + ,{ 60, -80, 60, -80, -370} + } + ,{{ 570, 420, 570, 420, 130} + ,{ 520, 370, 520, 370, 80} + ,{ 570, 420, 570, 420, 130} + ,{ 520, 370, 520, 370, 80} + ,{ -270, -420, -270, -420, -710} + } + } + ,{{{ 1350, -460, 720, 1350, 720} + ,{ 1300, -750, 520, 1300, 520} + ,{ 1350, -460, 570, 1350, 570} + ,{ 1300, -750, 720, 1300, 720} + ,{ 1250, -570, 460, 1250, 460} + } + ,{{ 1160, -900, 370, 1160, 370} + ,{ 1160, -900, 370, 1160, 370} + ,{ 850, -1210, 60, 850, 60} + ,{ 160, -1110, 160, -310, 160} + ,{ 850, -1210, 60, 850, 60} + } + ,{{ 1300, -520, 520, 1300, 520} + ,{ 1300, -750, 520, 1300, 520} + ,{ 1290, -520, 510, 1290, 510} + ,{ 1300, -750, 520, 1300, 520} + ,{ 1250, -570, 460, 1250, 460} + } + ,{{ 850, -1210, 720, 850, 720} + ,{ -120, -1400, -120, -590, -120} + ,{ 850, -1210, 60, 850, 60} + ,{ 720, -1810, 720, -1000, 720} + ,{ 850, -1210, 60, 850, 60} + } + ,{{ 1350, -460, 570, 1350, 570} + ,{ 1300, -750, 520, 1300, 520} + ,{ 1350, -460, 570, 1350, 570} + ,{ 1300, -750, 520, 1300, 520} + ,{ -270, -1540, -270, -740, -270} + } + } + ,{{{ 590, 570, 590, 570, -320} + ,{ 390, 370, 390, 370, -320} + ,{ 440, 420, 440, 420, -360} + ,{ 590, 570, 590, 570, -420} + ,{ 330, 310, 330, 310, -470} + } + ,{{ 270, 220, 270, 220, -320} + ,{ 240, 220, 240, 220, -320} + ,{ -60, -80, -60, -80, -870} + ,{ 270, 10, 270, 10, -780} + ,{ -60, -80, -60, -80, -870} + } + ,{{ 390, 370, 390, 370, -420} + ,{ 390, 370, 390, 370, -420} + ,{ 380, 360, 380, 360, -420} + ,{ 390, 370, 390, 370, -420} + ,{ 330, 310, 330, 310, -470} + } + ,{{ 590, 570, 590, 570, -870} + ,{ -10, -270, -10, -270, -1060} + ,{ -60, -80, -60, -80, -870} + ,{ 590, 570, 590, 570, -1470} + ,{ -60, -80, -60, -80, -870} + } + ,{{ 440, 420, 440, 420, -360} + ,{ 390, 370, 390, 370, -420} + ,{ 440, 420, 440, 420, -360} + ,{ 390, 370, 390, 370, -420} + ,{ -400, -420, -400, -420, -1210} + } + } + } + ,{{{{ 1320, 850, 720, 1320, 720} + ,{ 1320, 670, 540, 1320, 540} + ,{ 870, 220, 90, 870, 90} + ,{ 960, 850, 720, 960, 720} + ,{ 870, 250, 90, 870, 90} + } + ,{{ 1320, 670, 540, 1320, 540} + ,{ 1320, 670, 540, 1320, 540} + ,{ 870, 220, 90, 870, 90} + ,{ -410, -520, -410, -800, -650} + ,{ 870, 220, 90, 870, 90} + } + ,{{ 960, 300, 170, 960, 170} + ,{ 960, 300, 170, 960, 170} + ,{ 650, 0, -130, 650, -130} + ,{ 960, 300, 170, 960, 170} + ,{ 650, 0, -130, 650, -130} + } + ,{{ 870, 850, 720, 870, 720} + ,{ 70, -40, 70, -320, -170} + ,{ 870, 220, 90, 870, 90} + ,{ 850, 850, 720, 570, 720} + ,{ 870, 220, 90, 870, 90} + } + ,{{ 960, 300, 170, 960, 170} + ,{ 960, 300, 170, 960, 170} + ,{ 340, -310, -440, 340, -440} + ,{ 960, 300, 170, 960, 170} + ,{ 250, 250, -110, -260, -110} + } + } + ,{{{ 850, 850, 720, -1030, 720} + ,{ 670, 670, 540, -1030, 540} + ,{ 220, 220, 90, -1460, 90} + ,{ 850, 850, 720, -1400, 720} + ,{ 250, 250, 90, -1460, 90} + } + ,{{ 670, 670, 540, -1030, 540} + ,{ 670, 670, 540, -1030, 540} + ,{ 220, 220, 90, -1480, 90} + ,{ -520, -520, -650, -2220, -650} + ,{ 220, 220, 90, -1480, 90} + } + ,{{ 300, 300, 170, -1400, 170} + ,{ 300, 300, 170, -1400, 170} + ,{ 0, 0, -130, -1460, -130} + ,{ 300, 300, 170, -1400, 170} + ,{ 0, 0, -130, -1460, -130} + } + ,{{ 850, 850, 720, -1480, 720} + ,{ -40, -40, -170, -1750, -170} + ,{ 220, 220, 90, -1480, 90} + ,{ 850, 850, 720, -2110, 720} + ,{ 220, 220, 90, -1480, 90} + } + ,{{ 300, 300, 170, -1400, 170} + ,{ 300, 300, 170, -1400, 170} + ,{ -310, -310, -440, -1770, -440} + ,{ 300, 300, 170, -1400, 170} + ,{ 250, 250, -110, -1690, -110} + } + } + ,{{{ 720, 570, 720, 570, 280} + ,{ 540, 390, 540, 390, 100} + ,{ 90, -60, 90, -60, -350} + ,{ 720, 570, 720, 570, 280} + ,{ 90, -60, 90, -60, -350} + } + ,{{ 540, 390, 540, 390, 100} + ,{ 540, 390, 540, 390, 100} + ,{ 90, -60, 90, -60, -350} + ,{ -410, -800, -410, -800, -850} + ,{ 90, -60, 90, -60, -350} + } + ,{{ 170, 20, 170, 20, -260} + ,{ 170, 20, 170, 20, -260} + ,{ -130, -280, -130, -280, -570} + ,{ 170, 20, 170, 20, -260} + ,{ -130, -280, -130, -280, -570} + } + ,{{ 720, 570, 720, 570, 280} + ,{ 70, -320, 70, -320, -370} + ,{ 90, -60, 90, -60, -350} + ,{ 720, 570, 720, 570, 280} + ,{ 90, -60, 90, -60, -350} + } + ,{{ 170, 20, 170, 20, -260} + ,{ 170, 20, 170, 20, -260} + ,{ -440, -590, -440, -590, -880} + ,{ 170, 20, 170, 20, -260} + ,{ -110, -260, -110, -260, -550} + } + } + ,{{{ 1320, -730, 720, 1320, 720} + ,{ 1320, -730, 540, 1320, 540} + ,{ 870, -1160, 90, 870, 90} + ,{ 960, -1100, 720, 960, 720} + ,{ 870, -1160, 90, 870, 90} + } + ,{{ 1320, -730, 540, 1320, 540} + ,{ 1320, -730, 540, 1320, 540} + ,{ 870, -1180, 90, 870, 90} + ,{ -650, -1920, -650, -1120, -650} + ,{ 870, -1180, 90, 870, 90} + } + ,{{ 960, -1100, 170, 960, 170} + ,{ 960, -1100, 170, 960, 170} + ,{ 650, -1160, -130, 650, -130} + ,{ 960, -1100, 170, 960, 170} + ,{ 650, -1160, -130, 650, -130} + } + ,{{ 870, -1180, 720, 870, 720} + ,{ -170, -1450, -170, -640, -170} + ,{ 870, -1180, 90, 870, 90} + ,{ 720, -1810, 720, -1000, 720} + ,{ 870, -1180, 90, 870, 90} + } + ,{{ 960, -1100, 170, 960, 170} + ,{ 960, -1100, 170, 960, 170} + ,{ 340, -1470, -440, 340, -440} + ,{ 960, -1100, 170, 960, 170} + ,{ -110, -1390, -110, -580, -110} + } + } + ,{{{ 590, 570, 590, 570, -160} + ,{ 410, 390, 410, 390, -160} + ,{ -40, -60, -40, -60, -850} + ,{ 590, 570, 590, 570, -760} + ,{ -40, -60, -40, -60, -850} + } + ,{{ 410, 390, 410, 390, -160} + ,{ 410, 390, 410, 390, -160} + ,{ -40, -60, -40, -60, -850} + ,{ -540, -800, -540, -800, -1590} + ,{ -40, -60, -40, -60, -850} + } + ,{{ 40, 20, 40, 20, -760} + ,{ 40, 20, 40, 20, -760} + ,{ -260, -280, -260, -280, -1070} + ,{ 40, 20, 40, 20, -760} + ,{ -260, -280, -260, -280, -1070} + } + ,{{ 590, 570, 590, 570, -850} + ,{ -60, -320, -60, -320, -1110} + ,{ -40, -60, -40, -60, -850} + ,{ 590, 570, 590, 570, -1470} + ,{ -40, -60, -40, -60, -850} + } + ,{{ 40, 20, 40, 20, -760} + ,{ 40, 20, 40, 20, -760} + ,{ -570, -590, -570, -590, -1380} + ,{ 40, 20, 40, 20, -760} + ,{ -240, -260, -240, -260, -1050} + } + } + } + ,{{{{ 1010, 1010, 880, 730, 880} + ,{ 410, -70, 40, 410, -200} + ,{ 410, -240, -370, 410, -370} + ,{ 1010, 1010, 880, 730, 880} + ,{ 410, 0, -370, 410, -370} + } + ,{{ 410, -240, -150, 410, -370} + ,{ 230, -420, -550, 230, -550} + ,{ 410, -240, -370, 410, -370} + ,{ -150, -260, -150, -540, -390} + ,{ 410, -240, -370, 410, -370} + } + ,{{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + } + ,{{ 1010, 1010, 880, 730, 880} + ,{ 40, -70, 40, -350, -200} + ,{ 410, -240, -370, 410, -370} + ,{ 1010, 1010, 880, 730, 880} + ,{ 410, -240, -370, 410, -370} + } + ,{{ 410, 0, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 0, 0, -370, -520, -370} + } + } + ,{{{ 1010, 1010, 880, -1710, 880} + ,{ -70, -70, -200, -1770, -200} + ,{ -240, -240, -370, -1710, -370} + ,{ 1010, 1010, 880, -1950, 880} + ,{ 0, 0, -370, -1710, -370} + } + ,{{ -240, -240, -370, -1950, -370} + ,{ -420, -420, -550, -2130, -550} + ,{ -240, -240, -370, -1950, -370} + ,{ -260, -260, -390, -1960, -390} + ,{ -240, -240, -370, -1950, -370} + } + ,{{ -240, -240, -370, -1710, -370} + ,{ -240, -240, -370, -1950, -370} + ,{ -240, -240, -370, -1710, -370} + ,{ -240, -240, -370, -1950, -370} + ,{ -240, -240, -370, -1710, -370} + } + ,{{ 1010, 1010, 880, -1770, 880} + ,{ -70, -70, -200, -1770, -200} + ,{ -240, -240, -370, -1950, -370} + ,{ 1010, 1010, 880, -1950, 880} + ,{ -240, -240, -370, -1950, -370} + } + ,{{ 0, 0, -370, -1710, -370} + ,{ -240, -240, -370, -1950, -370} + ,{ -240, -240, -370, -1710, -370} + ,{ -240, -240, -370, -1950, -370} + ,{ 0, 0, -370, -1950, -370} + } + } + ,{{{ 880, 730, 880, 730, 440} + ,{ 40, -350, 40, -350, -400} + ,{ -370, -520, -370, -520, -810} + ,{ 880, 730, 880, 730, 440} + ,{ -370, -520, -370, -520, -810} + } + ,{{ -150, -520, -150, -520, -590} + ,{ -550, -700, -550, -700, -990} + ,{ -370, -520, -370, -520, -810} + ,{ -150, -540, -150, -540, -590} + ,{ -370, -520, -370, -520, -810} + } + ,{{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + } + ,{{ 880, 730, 880, 730, 440} + ,{ 40, -350, 40, -350, -400} + ,{ -370, -520, -370, -520, -810} + ,{ 880, 730, 880, 730, 440} + ,{ -370, -520, -370, -520, -810} + } + ,{{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + ,{ -370, -520, -370, -520, -810} + } + } + ,{{{ 880, -1410, 880, 410, 880} + ,{ 410, -1470, -200, 410, -200} + ,{ 410, -1410, -370, 410, -370} + ,{ 880, -1650, 880, 410, 880} + ,{ 410, -1410, -370, 410, -370} + } + ,{{ 410, -1650, -370, 410, -370} + ,{ 230, -1830, -550, 230, -550} + ,{ 410, -1650, -370, 410, -370} + ,{ -390, -1660, -390, -860, -390} + ,{ 410, -1650, -370, 410, -370} + } + ,{{ 410, -1410, -370, 410, -370} + ,{ 410, -1650, -370, 410, -370} + ,{ 410, -1410, -370, 410, -370} + ,{ 410, -1650, -370, 410, -370} + ,{ 410, -1410, -370, 410, -370} + } + ,{{ 880, -1470, 880, 410, 880} + ,{ -200, -1470, -200, -670, -200} + ,{ 410, -1650, -370, 410, -370} + ,{ 880, -1650, 880, -840, 880} + ,{ 410, -1650, -370, 410, -370} + } + ,{{ 410, -1410, -370, 410, -370} + ,{ 410, -1650, -370, 410, -370} + ,{ 410, -1410, -370, 410, -370} + ,{ 410, -1650, -370, 410, -370} + ,{ -370, -1650, -370, -840, -370} + } + } + ,{{{ 750, 730, 750, 730, -1140} + ,{ -90, -350, -90, -350, -1140} + ,{ -500, -520, -500, -520, -1310} + ,{ 750, 730, 750, 730, -1310} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ -280, -520, -280, -520, -1250} + ,{ -680, -700, -680, -700, -1250} + ,{ -500, -520, -500, -520, -1310} + ,{ -280, -540, -280, -540, -1330} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ 750, 730, 750, 730, -1140} + ,{ -90, -350, -90, -350, -1140} + ,{ -500, -520, -500, -520, -1310} + ,{ 750, 730, 750, 730, -1310} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + } + } + } + ,{{{{ 1560, 1560, 1430, 1470, 1430} + ,{ 1470, 820, 690, 1470, 690} + ,{ 960, 310, 180, 960, 180} + ,{ 1560, 1560, 1430, 1280, 1430} + ,{ 960, 550, 180, 960, 180} + } + ,{{ 1470, 820, 690, 1470, 690} + ,{ 1470, 820, 690, 1470, 690} + ,{ 960, 310, 180, 960, 180} + ,{ 80, -30, 80, -310, -160} + ,{ 960, 310, 180, 960, 180} + } + ,{{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + } + ,{{ 1560, 1560, 1430, 1280, 1430} + ,{ -90, -200, -90, -480, -330} + ,{ 960, 310, 180, 960, 180} + ,{ 1560, 1560, 1430, 1280, 1430} + ,{ 960, 310, 180, 960, 180} + } + ,{{ 960, 550, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 550, 550, 180, 30, 180} + } + } + ,{{{ 1560, 1560, 1430, -880, 1430} + ,{ 820, 820, 690, -880, 690} + ,{ 310, 310, 180, -1150, 180} + ,{ 1560, 1560, 1430, -1390, 1430} + ,{ 550, 550, 180, -1150, 180} + } + ,{{ 820, 820, 690, -880, 690} + ,{ 820, 820, 690, -880, 690} + ,{ 310, 310, 180, -1390, 180} + ,{ -30, -30, -160, -1730, -160} + ,{ 310, 310, 180, -1390, 180} + } + ,{{ 310, 310, 180, -1150, 180} + ,{ 310, 310, 180, -1390, 180} + ,{ 310, 310, 180, -1150, 180} + ,{ 310, 310, 180, -1390, 180} + ,{ 310, 310, 180, -1150, 180} + } + ,{{ 1560, 1560, 1430, -1390, 1430} + ,{ -200, -200, -330, -1900, -330} + ,{ 310, 310, 180, -1390, 180} + ,{ 1560, 1560, 1430, -1390, 1430} + ,{ 310, 310, 180, -1390, 180} + } + ,{{ 550, 550, 180, -1150, 180} 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INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + } + ,{{{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + ,{ INF, INF, INF, INF, INF} + } + ,{{ INF, INF, INF, INF, INF} + ,{ INF, 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-400} + ,{ -260, -280, -260, -280, -1070} + ,{ 40, 20, 40, 20, -760} + ,{ -260, -280, -260, -280, -1070} + } + ,{{ 590, 570, 590, 570, -230} + ,{ -60, -320, -60, -320, -1110} + ,{ -40, -60, -40, -60, -850} + ,{ 590, 570, 590, 570, -230} + ,{ -40, -60, -40, -60, -850} + } + ,{{ 40, 20, 40, 20, -760} + ,{ 40, 20, 40, 20, -760} + ,{ -570, -590, -570, -590, -1380} + ,{ 40, 20, 40, 20, -760} + ,{ -240, -260, -240, -260, -1050} + } + } + } + ,{{{{ 1010, 1010, 880, 730, 880} + ,{ 410, -30, 40, 410, -190} + ,{ 410, -240, -370, 410, -370} + ,{ 1010, 1010, 880, 730, 880} + ,{ 410, 0, -370, 410, -370} + } + ,{{ 410, -70, -150, 410, -370} + ,{ 230, -70, -550, 230, -550} + ,{ 410, -240, -370, 410, -370} + ,{ -150, -260, -150, -540, -380} + ,{ 410, -240, -370, 410, -370} + } + ,{{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + } + ,{{ 1010, 1010, 880, 730, 880} + ,{ 40, -30, 40, -350, -190} + ,{ 410, -240, -370, 410, -370} + ,{ 1010, 1010, 880, 730, 880} + ,{ 410, -240, -370, 410, -370} + } + ,{{ 410, 0, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 410, -240, -370, 410, -370} + ,{ 0, 0, -370, -520, -370} + } + } + ,{{{ 1010, 1010, 880, -1280, 880} + ,{ -30, -30, -200, -1340, -200} + ,{ -240, -240, -370, -1280, -370} + ,{ 1010, 1010, 880, -1520, 880} + ,{ 0, 0, -370, -1280, -370} + } + ,{{ -70, -70, -370, -1520, -370} + ,{ -70, -70, -550, -1700, -550} + ,{ -240, -240, -370, -1520, -370} + ,{ -260, -260, -390, -1530, -390} + ,{ -240, -240, -370, -1520, -370} + } + ,{{ -240, -240, -370, -1280, -370} + ,{ -240, -240, -370, -1520, -370} + ,{ -240, -240, -370, -1280, -370} + ,{ -240, -240, -370, -1520, -370} + ,{ -240, -240, -370, -1280, -370} + } + ,{{ 1010, 1010, 880, -1340, 880} + ,{ -30, -30, -200, -1340, -200} + ,{ -240, -240, -370, -1520, -370} + ,{ 1010, 1010, 880, -1520, 880} + ,{ -240, -240, -370, -1520, -370} + } + ,{{ 0, 0, -370, -1280, -370} + ,{ -240, -240, -370, -1520, -370} + ,{ -240, -240, -370, -1280, -370} + ,{ -240, -240, -370, -1520, -370} + ,{ 0, 0, -370, -1520, -370} + } + } + ,{{{ 880, 730, 880, 730, 640} + ,{ 40, -350, 40, -350, -190} + ,{ -370, -520, -370, -520, -610} + ,{ 880, 730, 880, 730, 640} + ,{ -370, -520, -370, -520, -610} + } + ,{{ -150, -520, -150, -520, -380} + ,{ -550, -700, -550, -700, -790} + ,{ -370, -520, -370, -520, -610} + ,{ -150, -540, -150, -540, -380} + ,{ -370, -520, -370, -520, -610} + } + ,{{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + } + ,{{ 880, 730, 880, 730, 640} + ,{ 40, -350, 40, -350, -190} + ,{ -370, -520, -370, -520, -610} + ,{ 880, 730, 880, 730, 640} + ,{ -370, -520, -370, -520, -610} + } + ,{{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + ,{ -370, -520, -370, -520, -610} + } + } + ,{{{ 880, -1180, 880, 410, 880} + ,{ 410, -1250, -200, 410, -200} + ,{ 410, -1180, -370, 410, -370} + ,{ 880, -1420, 880, 410, 880} + ,{ 410, -1180, -370, 410, -370} + } + ,{{ 410, -1420, -370, 410, -370} + ,{ 230, -1600, -550, 230, -550} + ,{ 410, -1420, -370, 410, -370} + ,{ -390, -1440, -390, -860, -390} + ,{ 410, -1420, -370, 410, -370} + } + ,{{ 410, -1180, -370, 410, -370} + ,{ 410, -1420, -370, 410, -370} + ,{ 410, -1180, -370, 410, -370} + ,{ 410, -1420, -370, 410, -370} + ,{ 410, -1180, -370, 410, -370} + } + ,{{ 880, -1250, 880, 410, 880} + ,{ -200, -1250, -200, -670, -200} + ,{ 410, -1420, -370, 410, -370} + ,{ 880, -1420, 880, -840, 880} + ,{ 410, -1420, -370, 410, -370} + } + ,{{ 410, -1180, -370, 410, -370} + ,{ 410, -1420, -370, 410, -370} + ,{ 410, -1180, -370, 410, -370} + ,{ 410, -1420, -370, 410, -370} + ,{ -370, -1420, -370, -840, -370} + } + } + ,{{{ 750, 730, 750, 730, -1140} + ,{ -90, -350, -90, -350, -1140} + ,{ -500, -520, -500, -520, -1310} + ,{ 750, 730, 750, 730, -1310} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ -280, -520, -280, -520, -1250} + ,{ -680, -700, -680, -700, -1250} + ,{ -500, -520, -500, -520, -1310} + ,{ -280, -540, -280, -540, -1330} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ 750, 730, 750, 730, -1140} + ,{ -90, -350, -90, -350, -1140} + ,{ -500, -520, -500, -520, -1310} + ,{ 750, 730, 750, 730, -1310} + ,{ -500, -520, -500, -520, -1310} + } + ,{{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + ,{ -500, -520, -500, -520, -1310} + } + } + } + ,{{{{ 1560, 1560, 1430, 1470, 1430} + ,{ 1470, 820, 690, 1470, 690} + ,{ 960, 310, 180, 960, 180} + ,{ 1560, 1560, 1430, 1280, 1430} + ,{ 960, 550, 180, 960, 180} + } + ,{{ 1470, 820, 690, 1470, 690} + ,{ 1470, 820, 690, 1470, 690} + ,{ 960, 310, 180, 960, 180} + ,{ 80, -30, 80, -310, -150} + ,{ 960, 310, 180, 960, 180} + } + ,{{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + } + ,{{ 1560, 1560, 1430, 1280, 1430} + ,{ -90, -200, -90, -480, -320} + ,{ 960, 310, 180, 960, 180} + ,{ 1560, 1560, 1430, 1280, 1430} + ,{ 960, 310, 180, 960, 180} + } + ,{{ 960, 550, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 960, 310, 180, 960, 180} + ,{ 550, 550, 180, 30, 180} + } + } + ,{{{ 1560, 1560, 1430, -30, 1430} + ,{ 820, 820, 690, -30, 690} + ,{ 310, 310, 180, -720, 180} + ,{ 1560, 1560, 1430, -960, 1430} + ,{ 550, 550, 180, -720, 180} + } + ,{{ 820, 820, 690, -30, 690} + ,{ 820, 820, 690, -30, 690} + ,{ 310, 310, 180, -960, 180} + ,{ -30, -30, -160, -1300, -160} + ,{ 310, 310, 180, -960, 180} + } + ,{{ 310, 310, 180, -720, 180} + ,{ 310, 310, 180, -960, 180} + ,{ 310, 310, 180, -720, 180} + ,{ 310, 310, 180, -960, 180} + ,{ 310, 310, 180, -720, 180} + } + ,{{ 1560, 1560, 1430, -960, 1430} + ,{ -200, -200, -330, -1470, -330} + ,{ 310, 310, 180, -960, 180} + ,{ 1560, 1560, 1430, -960, 1430} + ,{ 310, 310, 180, -960, 180} + } + ,{{ 550, 550, 180, -720, 180} + ,{ 310, 310, 180, -960, 180} + ,{ 310, 310, 180, -720, 180} + ,{ 310, 310, 180, -960, 180} + ,{ 550, 550, 180, -960, 180} + } + } + ,{{{ 1430, 1280, 1430, 1280, 1200} + ,{ 690, 540, 690, 540, 450} + ,{ 180, 30, 180, 30, -50} + ,{ 1430, 1280, 1430, 1280, 1200} + ,{ 180, 30, 180, 30, -50} + } + ,{{ 690, 540, 690, 540, 450} + ,{ 690, 540, 690, 540, 450} + ,{ 180, 30, 180, 30, -50} + ,{ 80, -310, 80, -310, -150} + ,{ 180, 30, 180, 30, -50} + } + ,{{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + } + ,{{ 1430, 1280, 1430, 1280, 1200} + ,{ -90, -480, -90, -480, -320} + ,{ 180, 30, 180, 30, -50} + ,{ 1430, 1280, 1430, 1280, 1200} + ,{ 180, 30, 180, 30, -50} + } + ,{{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + ,{ 180, 30, 180, 30, -50} + } + } + ,{{{ 1470, -360, 1430, 1470, 1430} + ,{ 1470, -360, 690, 1470, 690} + ,{ 960, -630, 180, 960, 180} + ,{ 1430, -870, 1430, 960, 1430} + ,{ 960, -630, 180, 960, 180} + } + ,{{ 1470, -360, 690, 1470, 690} + ,{ 1470, -360, 690, 1470, 690} + ,{ 960, -870, 180, 960, 180} + ,{ -160, -1210, -160, -630, -160} + ,{ 960, -870, 180, 960, 180} + } + ,{{ 960, -630, 180, 960, 180} + ,{ 960, -870, 180, 960, 180} + ,{ 960, -630, 180, 960, 180} + ,{ 960, -870, 180, 960, 180} + ,{ 960, -630, 180, 960, 180} + } + ,{{ 1430, -870, 1430, 960, 1430} + ,{ -330, -1380, -330, -800, -330} + ,{ 960, -870, 180, 960, 180} + ,{ 1430, -870, 1430, -290, 1430} + ,{ 960, -870, 180, 960, 180} + } + ,{{ 960, -630, 180, 960, 180} + ,{ 960, -870, 180, 960, 180} + ,{ 960, -630, 180, 960, 180} + ,{ 960, -870, 180, 960, 180} + ,{ 180, -870, 180, -290, 180} + } + } + ,{{{ 1300, 1280, 1300, 1280, -10} + ,{ 560, 540, 560, 540, -10} + ,{ 50, 30, 50, 30, -760} + ,{ 1300, 1280, 1300, 1280, -760} + ,{ 50, 30, 50, 30, -760} + } + ,{{ 560, 540, 560, 540, -10} + ,{ 560, 540, 560, 540, -10} + ,{ 50, 30, 50, 30, -760} + ,{ -50, -310, -50, -310, -1100} + ,{ 50, 30, 50, 30, -760} + } + ,{{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + } + ,{{ 1300, 1280, 1300, 1280, -760} + ,{ -220, -480, -220, -480, -1270} + ,{ 50, 30, 50, 30, -760} + ,{ 1300, 1280, 1300, 1280, -760} + ,{ 50, 30, 50, 30, -760} + } + ,{{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + ,{ 50, 30, 50, 30, -760} + } + } + } + ,{{{{ 2050, 1930, 1800, 2050, 1800} + ,{ 2050, 1400, 1270, 2050, 1270} + ,{ 1750, 1100, 970, 1750, 970} + ,{ 1930, 1930, 1800, 1760, 1800} + ,{ 1750, 1100, 970, 1750, 970} + } + ,{{ 2050, 1400, 1270, 2050, 1270} + ,{ 2050, 1400, 1270, 2050, 1270} + ,{ 1740, 1090, 960, 1740, 960} + ,{ 130, 10, 130, -260, -110} + ,{ 1740, 1090, 960, 1740, 960} + } + ,{{ 1760, 1110, 980, 1760, 980} + ,{ 1760, 1110, 980, 1760, 980} + ,{ 1750, 1100, 970, 1750, 970} + ,{ 1760, 1110, 980, 1760, 980} + ,{ 1750, 1100, 970, 1750, 970} + } + ,{{ 1930, 1930, 1800, 1740, 1800} + ,{ 300, 190, 300, -80, 70} + ,{ 1740, 1090, 960, 1740, 960} + ,{ 1930, 1930, 1800, 1650, 1800} + ,{ 1740, 1090, 960, 1740, 960} + } + ,{{ 1760, 1110, 980, 1760, 980} + ,{ 1760, 1110, 980, 1760, 980} + ,{ 1750, 1100, 970, 1750, 970} + ,{ 1760, 1110, 980, 1760, 980} + ,{ 360, 360, 0, -150, 0} + } + } + ,{{{ 1930, 1930, 1800, 130, 1800} + ,{ 1400, 1400, 1270, 130, 1270} + ,{ 1100, 1100, 970, 70, 970} + ,{ 1930, 1930, 1800, -160, 1800} + ,{ 1100, 1100, 970, 70, 970} + } + ,{{ 1400, 1400, 1270, 130, 1270} + ,{ 1400, 1400, 1270, 130, 1270} + ,{ 1090, 1090, 960, -180, 960} + ,{ 10, 10, -110, -1260, -110} + ,{ 1090, 1090, 960, -180, 960} + } + ,{{ 1110, 1110, 980, 70, 980} + ,{ 1110, 1110, 980, -160, 980} + ,{ 1100, 1100, 970, 70, 970} + ,{ 1110, 1110, 980, -160, 980} + ,{ 1100, 1100, 970, 70, 970} + } + ,{{ 1930, 1930, 1800, -180, 1800} + ,{ 190, 190, 60, -1080, 60} + ,{ 1090, 1090, 960, -180, 960} + ,{ 1930, 1930, 1800, -590, 1800} + ,{ 1090, 1090, 960, -180, 960} + } + ,{{ 1110, 1110, 980, 70, 980} + ,{ 1110, 1110, 980, -160, 980} + ,{ 1100, 1100, 970, 70, 970} + ,{ 1110, 1110, 980, -160, 980} + ,{ 360, 360, 0, -1150, 0} + } + } + ,{{{ 1800, 1650, 1800, 1650, 1570} + ,{ 1270, 1120, 1270, 1120, 1040} + ,{ 970, 820, 970, 820, 740} + ,{ 1800, 1650, 1800, 1650, 1570} + ,{ 970, 820, 970, 820, 740} + } + ,{{ 1270, 1120, 1270, 1120, 1040} + ,{ 1270, 1120, 1270, 1120, 1040} + ,{ 960, 810, 960, 810, 730} + ,{ 130, -260, 130, -260, -110} + ,{ 960, 810, 960, 810, 730} + } + ,{{ 980, 830, 980, 830, 740} + ,{ 980, 830, 980, 830, 740} + ,{ 970, 820, 970, 820, 740} + ,{ 980, 830, 980, 830, 740} + ,{ 970, 820, 970, 820, 740} + } + ,{{ 1800, 1650, 1800, 1650, 1570} + ,{ 300, -80, 300, -80, 70} + ,{ 960, 810, 960, 810, 730} + ,{ 1800, 1650, 1800, 1650, 1570} + ,{ 960, 810, 960, 810, 730} + } + ,{{ 980, 830, 980, 830, 740} + ,{ 980, 830, 980, 830, 740} + ,{ 970, 820, 970, 820, 740} + ,{ 980, 830, 980, 830, 740} + ,{ 0, -150, 0, -150, -240} + } + } + ,{{{ 2050, 220, 1800, 2050, 1800} + ,{ 2050, 220, 1270, 2050, 1270} + ,{ 1750, 170, 970, 1750, 970} + ,{ 1800, -70, 1800, 1760, 1800} + ,{ 1750, 170, 970, 1750, 970} + } + ,{{ 2050, 220, 1270, 2050, 1270} + ,{ 2050, 220, 1270, 2050, 1270} + ,{ 1740, -80, 960, 1740, 960} + ,{ -110, -1160, -110, -580, -110} + ,{ 1740, -80, 960, 1740, 960} + } + ,{{ 1760, 170, 980, 1760, 980} + ,{ 1760, -70, 980, 1760, 980} + ,{ 1750, 170, 970, 1750, 970} + ,{ 1760, -70, 980, 1760, 980} + ,{ 1750, 170, 970, 1750, 970} + } + ,{{ 1800, -80, 1800, 1740, 1800} + ,{ 60, -980, 60, -400, 60} + ,{ 1740, -80, 960, 1740, 960} + ,{ 1800, -490, 1800, 80, 1800} + ,{ 1740, -80, 960, 1740, 960} + } + ,{{ 1760, 170, 980, 1760, 980} + ,{ 1760, -70, 980, 1760, 980} + ,{ 1750, 170, 970, 1750, 970} + ,{ 1760, -70, 980, 1760, 980} + ,{ 0, -1050, 0, -470, 0} + } + } + ,{{{ 1670, 1650, 1670, 1650, 570} + ,{ 1140, 1120, 1140, 1120, 570} + ,{ 840, 820, 840, 820, 30} + ,{ 1670, 1650, 1670, 1650, 40} + ,{ 840, 820, 840, 820, 30} + } + ,{{ 1140, 1120, 1140, 1120, 570} + ,{ 1140, 1120, 1140, 1120, 570} + ,{ 830, 810, 830, 810, 20} + ,{ 0, -260, 0, -260, -1050} + ,{ 830, 810, 830, 810, 20} + } + ,{{ 850, 830, 850, 830, 40} + ,{ 850, 830, 850, 830, 40} + ,{ 840, 820, 840, 820, 30} + ,{ 850, 830, 850, 830, 40} + ,{ 840, 820, 840, 820, 30} + } + ,{{ 1670, 1650, 1670, 1650, 20} + ,{ 180, -80, 180, -80, -870} + ,{ 830, 810, 830, 810, 20} + ,{ 1670, 1650, 1670, 1650, -380} + ,{ 830, 810, 830, 810, 20} + } + ,{{ 850, 830, 850, 830, 40} + ,{ 850, 830, 850, 830, 40} + ,{ 840, 820, 840, 820, 30} + ,{ 850, 830, 850, 830, 40} + ,{ -130, -150, -130, -150, -940} + } + } + } + ,{{{{ 2120, 2120, 1990, 2120, 1990} + ,{ 2120, 1470, 1340, 2120, 1340} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 2120, 2120, 1990, 1990, 1990} + ,{ 1860, 1210, 1080, 1860, 1080} + } + ,{{ 2120, 1470, 1340, 2120, 1340} + ,{ 2120, 1470, 1340, 2120, 1340} + ,{ 1840, 1190, 1060, 1840, 1060} + ,{ 180, 60, 180, -210, -60} + ,{ 1840, 1190, 1060, 1840, 1060} + } + ,{{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1860, 1210, 1080, 1860, 1080} + } + ,{{ 2120, 2120, 1990, 1840, 1990} + ,{ -120, -230, -120, -510, -360} + ,{ 1840, 1190, 1060, 1840, 1060} + ,{ 2120, 2120, 1990, 1840, 1990} + ,{ 1840, 1190, 1060, 1840, 1060} + } + ,{{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1550, 900, 770, 1550, 770} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 640, 640, 270, 120, 270} + } + } + ,{{{ 2120, 2120, 1990, 300, 1990} + ,{ 1470, 1470, 1340, 190, 1340} + ,{ 1340, 1340, 1210, 300, 1210} + ,{ 2120, 2120, 1990, 60, 1990} + ,{ 1210, 1210, 1080, 180, 1080} + } + ,{{ 1470, 1470, 1340, 190, 1340} + ,{ 1470, 1470, 1340, 190, 1340} + ,{ 1190, 1190, 1060, -80, 1060} + ,{ 60, 60, -60, -1210, -60} + ,{ 1190, 1190, 1060, -80, 1060} + } + ,{{ 1340, 1340, 1210, 300, 1210} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 1340, 1340, 1210, 300, 1210} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 1210, 1210, 1080, 180, 1080} + } + ,{{ 2120, 2120, 1990, -80, 1990} + ,{ -230, -230, -360, -1510, -360} + ,{ 1190, 1190, 1060, -80, 1060} + ,{ 2120, 2120, 1990, -400, 1990} + ,{ 1190, 1190, 1060, -80, 1060} + } + ,{{ 1340, 1340, 1210, 60, 1210} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 900, 900, 770, -130, 770} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 640, 640, 270, -870, 270} + } + } + ,{{{ 1990, 1840, 1990, 1840, 1750} + ,{ 1340, 1190, 1340, 1190, 1100} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1990, 1840, 1990, 1840, 1750} + ,{ 1080, 930, 1080, 930, 840} + } + ,{{ 1340, 1190, 1340, 1190, 1100} + ,{ 1340, 1190, 1340, 1190, 1100} + ,{ 1060, 910, 1060, 910, 820} + ,{ 180, -210, 180, -210, -60} + ,{ 1060, 910, 1060, 910, 820} + } + ,{{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1080, 930, 1080, 930, 840} + } + ,{{ 1990, 1840, 1990, 1840, 1750} + ,{ -120, -510, -120, -510, -360} + ,{ 1060, 910, 1060, 910, 820} + ,{ 1990, 1840, 1990, 1840, 1750} + ,{ 1060, 910, 1060, 910, 820} + } + ,{{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 770, 620, 770, 620, 530} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 270, 120, 270, 120, 30} + } + } + ,{{{ 2120, 400, 1990, 2120, 1990} + ,{ 2120, 290, 1340, 2120, 1340} + ,{ 1990, 400, 1210, 1990, 1210} + ,{ 1990, 160, 1990, 1990, 1990} + ,{ 1860, 270, 1080, 1860, 1080} + } + ,{{ 2120, 290, 1340, 2120, 1340} + ,{ 2120, 290, 1340, 2120, 1340} + ,{ 1840, 10, 1060, 1840, 1060} + ,{ -60, -1110, -60, -530, -60} + ,{ 1840, 10, 1060, 1840, 1060} + } + ,{{ 1990, 400, 1210, 1990, 1210} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 1990, 400, 1210, 1990, 1210} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 1860, 270, 1080, 1860, 1080} + } + ,{{ 1990, 10, 1990, 1840, 1990} + ,{ -360, -1410, -360, -830, -360} + ,{ 1840, 10, 1060, 1840, 1060} + ,{ 1990, -310, 1990, 270, 1990} + ,{ 1840, 10, 1060, 1840, 1060} + } + ,{{ 1990, 160, 1210, 1990, 1210} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 1550, -40, 770, 1550, 770} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 270, -780, 270, -200, 270} + } + } + ,{{{ 1860, 1840, 1860, 1840, 640} + ,{ 1210, 1190, 1210, 1190, 640} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 1860, 1840, 1860, 1840, 270} + ,{ 950, 930, 950, 930, 140} + } + ,{{ 1210, 1190, 1210, 1190, 640} + ,{ 1210, 1190, 1210, 1190, 640} + ,{ 930, 910, 930, 910, 120} + ,{ 50, -210, 50, -210, -1000} + ,{ 930, 910, 930, 910, 120} + } + ,{{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 950, 930, 950, 930, 140} + } + ,{{ 1860, 1840, 1860, 1840, 120} + ,{ -250, -510, -250, -510, -1300} + ,{ 930, 910, 930, 910, 120} + ,{ 1860, 1840, 1860, 1840, -200} + ,{ 930, 910, 930, 910, 120} + } + ,{{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 640, 620, 640, 620, -170} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 140, 120, 140, 120, -670} + } + } + } + ,{{{{ 2120, 2120, 1990, 2120, 1990} + ,{ 2120, 1470, 1340, 2120, 1340} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 2120, 2120, 1990, 1990, 1990} + ,{ 1860, 1210, 1080, 1860, 1080} + } + ,{{ 2120, 1470, 1340, 2120, 1340} + ,{ 2120, 1470, 1340, 2120, 1340} + ,{ 1840, 1190, 1060, 1840, 1060} + ,{ 400, 290, 400, 10, 170} + ,{ 1840, 1190, 1060, 1840, 1060} + } + ,{{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1860, 1210, 1080, 1860, 1080} + } + ,{{ 2120, 2120, 1990, 1840, 1990} + ,{ 540, 190, 540, -80, 70} + ,{ 1840, 1190, 1060, 1840, 1060} + ,{ 2120, 2120, 1990, 1840, 1990} + ,{ 1840, 1190, 1060, 1840, 1060} + } + ,{{ 1990, 1340, 1210, 1990, 1210} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 1750, 1100, 970, 1750, 970} + ,{ 1990, 1340, 1210, 1990, 1210} + ,{ 640, 640, 270, 120, 270} + } + } + ,{{{ 2120, 2120, 1990, 540, 1990} + ,{ 1470, 1470, 1340, 190, 1340} + ,{ 1340, 1340, 1210, 540, 1210} + ,{ 2120, 2120, 1990, 60, 1990} + ,{ 1210, 1210, 1080, 180, 1080} + } + ,{{ 1470, 1470, 1340, 190, 1340} + ,{ 1470, 1470, 1340, 190, 1340} + ,{ 1190, 1190, 1060, -80, 1060} + ,{ 290, 290, 160, -980, 160} + ,{ 1190, 1190, 1060, -80, 1060} + } + ,{{ 1340, 1340, 1210, 540, 1210} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 1340, 1340, 1210, 540, 1210} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 1210, 1210, 1080, 180, 1080} + } + ,{{ 2120, 2120, 1990, -80, 1990} + ,{ 190, 190, 60, -1080, 60} + ,{ 1190, 1190, 1060, -80, 1060} + ,{ 2120, 2120, 1990, -400, 1990} + ,{ 1190, 1190, 1060, -80, 1060} + } + ,{{ 1340, 1340, 1210, 70, 1210} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 1100, 1100, 970, 70, 970} + ,{ 1340, 1340, 1210, 60, 1210} + ,{ 640, 640, 270, -810, 270} + } + } + ,{{{ 1990, 1840, 1990, 1840, 1750} + ,{ 1340, 1190, 1340, 1190, 1100} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1990, 1840, 1990, 1840, 1750} + ,{ 1080, 930, 1080, 930, 840} + } + ,{{ 1340, 1190, 1340, 1190, 1100} + ,{ 1340, 1190, 1340, 1190, 1100} + ,{ 1060, 910, 1060, 910, 820} + ,{ 400, 10, 400, 10, 170} + ,{ 1060, 910, 1060, 910, 820} + } + ,{{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 1080, 930, 1080, 930, 840} + } + ,{{ 1990, 1840, 1990, 1840, 1750} + ,{ 540, -80, 540, -80, 70} + ,{ 1060, 910, 1060, 910, 820} + ,{ 1990, 1840, 1990, 1840, 1750} + ,{ 1060, 910, 1060, 910, 820} + } + ,{{ 1210, 1060, 1210, 1060, 970} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 970, 820, 970, 820, 740} + ,{ 1210, 1060, 1210, 1060, 970} + ,{ 270, 120, 270, 120, 30} + } + } + ,{{{ 2120, 400, 1990, 2120, 1990} + ,{ 2120, 290, 1340, 2120, 1340} + ,{ 1990, 400, 1210, 1990, 1210} + ,{ 1990, 160, 1990, 1990, 1990} + ,{ 1860, 270, 1080, 1860, 1080} + } + ,{{ 2120, 290, 1340, 2120, 1340} + ,{ 2120, 290, 1340, 2120, 1340} + ,{ 1840, 10, 1060, 1840, 1060} + ,{ 160, -890, 160, -310, 160} + ,{ 1840, 10, 1060, 1840, 1060} + } + ,{{ 1990, 400, 1210, 1990, 1210} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 1990, 400, 1210, 1990, 1210} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 1860, 270, 1080, 1860, 1080} + } + ,{{ 1990, 10, 1990, 1840, 1990} + ,{ 60, -980, 60, -400, 60} + ,{ 1840, 10, 1060, 1840, 1060} + ,{ 1990, -310, 1990, 270, 1990} + ,{ 1840, 10, 1060, 1840, 1060} + } + ,{{ 1990, 170, 1210, 1990, 1210} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 1750, 170, 970, 1750, 970} + ,{ 1990, 160, 1210, 1990, 1210} + ,{ 270, -780, 270, -200, 270} + } + } + ,{{{ 1860, 1840, 1860, 1840, 640} + ,{ 1210, 1190, 1210, 1190, 640} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 1860, 1840, 1860, 1840, 270} + ,{ 950, 930, 950, 930, 140} + } + ,{{ 1210, 1190, 1210, 1190, 640} + ,{ 1210, 1190, 1210, 1190, 640} + ,{ 930, 910, 930, 910, 120} + ,{ 270, 10, 270, 10, -780} + ,{ 930, 910, 930, 910, 120} + } + ,{{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 950, 930, 950, 930, 140} + } + ,{{ 1860, 1840, 1860, 1840, 120} + ,{ 180, -80, 180, -80, -810} + ,{ 930, 910, 930, 910, 120} + ,{ 1860, 1840, 1860, 1840, -200} + ,{ 930, 910, 930, 910, 120} + } + ,{{ 1080, 1060, 1080, 1060, 270} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 840, 820, 840, 820, 30} + ,{ 1080, 1060, 1080, 1060, 270} + ,{ 140, 120, 140, 120, -670} + } + } + } + }}; diff --git a/include/list.h b/include/list.h new file mode 100644 --- /dev/null +++ b/include/list.h @@ -0,0 +1,65 @@ +/* + $Log: list.h,v $ + Revision 1.2 2000/10/10 08:50:01 ivo + some annotation for lclint + + Revision 1.1 1997/08/04 21:05:32 walter + Initial revision + +*/ + +#ifndef __LIST_H +#define __LIST_H + +/*---------------------- Macros and type definitions ----------------------*/ + +typedef struct LST_BUCKET { + struct LST_BUCKET *next; +} +LST_BUCKET; + +typedef struct { + int count; /* Number of elements currently in list */ + LST_BUCKET *head; /* Pointer to head element of list */ + LST_BUCKET *z; /* Pointer to last node of list */ + LST_BUCKET hz[2]; /* Space for head and z nodes */ +} +LIST; + +/* Return a pointer to the user space given the address of the header of + * a node. + */ + +#define LST_USERSPACE(h) ((void*)((LST_BUCKET*)(h) + 1)) + +/* Return a pointer to the header of a node, given the address of the + * user space. + */ + +#define LST_HEADER(n) ((LST_BUCKET*)(n) - 1) + +/* Return a pointer to the user space of the list's head node. This user + * space does not actually exist, but it is useful to be able to address + * it to enable insertion at the start of the list. + */ + +#define LST_HEAD(l) LST_USERSPACE((l)->head) + +/* Determine if a list is empty + */ + +#define LST_EMPTY(l) ((l)->count == 0) + +/*-------------------------- Function Prototypes --------------------------*/ + +/*@only@*//*@out@*/ void *lst_newnode (int size); +void lst_freenode (/*@only@*/ void *node); +/*@only@*//*@out@*/ LIST *lst_init (void); +void lst_kill (LIST * l, void (*freeNode) ()); +void lst_insertafter (LIST * l, /*@keep@*/ void *node, void *after); +void *lst_deletenext (/*@only@*/ LIST * l, void *node); +/*@dependent@*/ void *lst_first (LIST * l); +/*@dependent@*/ void *lst_next (void *prev); +void lst_mergesort (LIST * l, int (*cmp_func) ()); + +#endif diff --git a/include/loop_energies.h b/include/loop_energies.h new file mode 100644 --- /dev/null +++ b/include/loop_energies.h @@ -0,0 +1,660 @@ +#ifndef __VIENNA_RNA_PACKAGE_LOOP_ENERGIES_H__ +#define __VIENNA_RNA_PACKAGE_LOOP_ENERGIES_H__ + +#include +#include +#include +#include +#include +#include "params.h" +#include "fold_vars.h" +#include "energy_par.h" + +#ifdef __GNUC__ +# define INLINE inline +#else +# define INLINE +#endif + +/** + * \file loop_energies.h + * \brief Energy evaluation for MFE and partition function calculations + * + *

+ * This file contains functions for the calculation of the free energy \f$\Delta G\f$ + * of a hairpin- [ E_Hairpin() ] or interior-loop [ E_IntLoop()] .
+ * The unit of the free energy returned is \f$10^{-2} * \mathrm{kcal}/\mathrm{mol}\f$ + *

+ *

+ * In case of computing the partition function, this file also supplies functions + * which return the Boltzmann weights \f$e^{-\Delta G/kT} \f$ for a hairpin- [ exp_E_Hairpin() ] + * or interior-loop [ exp_E_IntLoop() ]. + *

+ */ + +/** + * \def E_MLstem(A,B,C,D) + *

Compute the Energy contribution of a Multiloop stem

+ * This definition is a wrapper for the E_Stem() funtion. + * It is substituted by an E_Stem() funtion call with argument + * extLoop=0, so the energy contribution returned reflects a + * stem introduced in a multiloop.
+ * As for the parameters B (si1) and C (sj1) of the substituted + * E_Stem() function, you can inhibit to take 5'-, 3'-dangles + * or mismatch contributions to be taken into account by passing + * -1 to these parameters. + * + * \see E_Stem() + * \param A The pair type of the stem-closing pair + * \param B The 5'-mismatching nucleotide + * \param C The 3'-mismatching nucleotide + * \param D The datastructure containing scaled energy parameters + * \return The energy contribution of the introduced multiloop stem + */ +INLINE PRIVATE int E_MLstem( int type, + int si1, + int sj1, + paramT *P); + +/** + * \def exp_E_MLstem(A,B,C,D) + * This is the partition function variant of \ref E_MLstem() + * \see E_MLstem() + * \return The Boltzmann weighted energy contribution of the introduced multiloop stem + */ +INLINE PRIVATE double exp_E_MLstem(int type, + int si1, + int sj1, + pf_paramT *P); + +/** + * \def E_ExtLoop(A,B,C,D) + *

Compute the Energy contribution of an Exterior loop stem

+ * This definition is a wrapper for the E_Stem() funtion. + * It is substituted by an E_Stem() funtion call with argument + * extLoop=1, so the energy contribution returned reflects a + * stem introduced in an exterior-loop.
+ * As for the parameters B (si1) and C (sj1) of the substituted + * E_Stem() function, you can inhibit to take 5'-, 3'-dangles + * or mismatch contributions to be taken into account by passing + * -1 to these parameters. + * + * \see E_Stem() + * \param A The pair type of the stem-closing pair + * \param B The 5'-mismatching nucleotide + * \param C The 3'-mismatching nucleotide + * \param D The datastructure containing scaled energy parameters + * \return The energy contribution of the introduced exterior-loop stem + */ +INLINE PRIVATE int E_ExtLoop(int type, + int si1, + int sj1, + paramT *P); + +/** + * \def exp_E_ExtLoop(A,B,C,D) + * This is the partition function variant of \ref E_ExtLoop() + * \see E_ExtLoop() + * \return The Boltzmann weighted energy contribution of the introduced exterior-loop stem + */ +INLINE PRIVATE double exp_E_ExtLoop( int type, + int si1, + int sj1, + pf_paramT *P); + +/** + *

Compute the Energy of an interior-loop

+ * This function computes the free energy \f$\Delta G\f$ of an interior-loop with the + * following structure:
+ * 
+ *        3'  5'
+ *        |   |
+ *        U - V
+ *    a_n       b_1
+ *     .        .
+ *     .        .
+ *     .        .
+ *    a_1       b_m
+ *        X - Y
+ *        |   |
+ *        5'  3'
+ *
+ * This general structure depicts an interior-loop that is closed by the base pair (X,Y). + * The enclosed base pair is (V,U) which leaves the unpaired bases a_1-a_n and b_1-b_n + * that constitute the loop. In this example, the length of the interior-loop is \f$(n+m)\f$ + * where n or m may be 0 resulting in a bulge-loop or base pair stack. + * The mismatching nucleotides for the closing pair (X,Y) are:
+ * 5'-mismatch: a_1
+ * 3'-mismatch: b_m
+ * and for the enclosed base pair (V,U):
+ * 5'-mismatch: b_1
+ * 3'-mismatch: a_n
+ * \note Base pairs are always denoted in 5'->3' direction. Thus the enclosed base pair + * must be 'turned arround' when evaluating the free energy of the interior-loop + * \see scale_parameters() + * \see paramT + * \note This function is threadsafe + * + * \param n1 The size of the 'left'-loop (number of unpaired nucleotides) + * \param n2 The size of the 'right'-loop (number of unpaired nucleotides) + * \param type The pair type of the base pair closing the interior loop + * \param type_2 The pair type of the enclosed base pair + * \param si1 The 5'-mismatching nucleotide of the closing pair + * \param sj1 The 3'-mismatching nucleotide of the closing pair + * \param sp1 The 3'-mismatching nucleotide of the enclosed pair + * \param sq1 The 5'-mismatching nucleotide of the enclosed pair + * \param P The datastructure containing scaled energy parameters + * \return The Free energy of the Interior-loop in dcal/mol + */ +INLINE PRIVATE int E_IntLoop(int n1, + int n2, + int type, + int type_2, + int si1, + int sj1, + int sp1, + int sq1, + paramT *P); + + +/** + *

Compute the Energy of a hairpin-loop

+ * To evaluate the free energy of a hairpin-loop, several parameters have to be known. + * A general hairpin-loop has this structure:
+ * 
+ *        a3 a4
+ *      a2     a5
+ *      a1     a6
+ *        X - Y
+ *        |   |
+ *        5'  3'
+ *
+ * where X-Y marks the closing pair [e.g. a (G,C) pair]. The length of this loop is 6 as there are + * six unpaired nucleotides (a1-a6) enclosed by (X,Y). The 5' mismatching nucleotide is + * a1 while the 3' mismatch is a6. The nucleotide sequence of this loop is "a1.a2.a3.a4.a5.a6"
+ * \note The parameter sequence should contain the sequence of the loop in capital letters of the nucleic acid + * alphabet if the loop size is below 7. This is useful for unusually stable tri-, tetra- and hexa-loops + * which are treated differently (based on experimental data) if they are tabulated. + * @see scale_parameters() + * @see paramT + * \warning Not (really) thread safe! A threadsafe implementation will replace this function in a future release!\n + * Energy evaluation may change due to updates in global variable "tetra_loop" + * + * \param size The size of the loop (number of unpaired nucleotides) + * \param type The pair type of the base pair closing the hairpin + * \param si1 The 5'-mismatching nucleotide + * \param sj1 The 3'-mismatching nucleotide + * \param string The sequence of the loop + * \param P The datastructure containing scaled energy parameters + * \return The Free energy of the Hairpin-loop in dcal/mol + */ +INLINE PRIVATE int E_Hairpin(int size, + int type, + int si1, + int sj1, + const char *string, + paramT *P); + +/** + *

Compute the energy contribution of a stem branching off a loop-region

+ * This function computes the energy contribution of a stem that branches off + * a loop region. This can be the case in multiloops, when a stem branching off + * increases the degree of the loop but also immediately interior base pairs + * of an exterior loop contribute free energy. + * To switch the bahavior of the function according to the evaluation of a multiloop- + * or exterior-loop-stem, you pass the flag 'extLoop'. + * The returned energy contribution consists of a TerminalAU penalty if the pair type + * is greater than 2, dangling end contributions of mismatching nucleotides adjacent to + * the stem if only one of the si1, sj1 parameters is greater than 0 and mismatch energies + * if both mismatching nucleotides are positive values. + * Thus, to avoid incooperating dangling end or mismatch energies just pass a negative number, + * e.g. -1 to the mismatch argument. + * + * This is an illustration of how the energy contribution is assembled: + * 
+ *        3'  5'
+ *        |   |
+ *        X - Y
+ *  5'-si1     sj1-3'
+ *
+ * + * Here, (X,Y) is the base pair that closes the stem that branches off a loop region. + * The nucleotides si1 and sj1 are the 5'- and 3'- mismatches, respectively. If the base pair + * type of (X,Y) is greater than 2 (i.e. an A-U or G-U pair, the TerminalAU penalty will be + * included in the energy contribution returned. If si1 and sj1 are both nonnegative numbers, + * mismatch energies will also be included. If one of sij or sj1 is a negtive value, only + * 5' or 3' dangling end contributions are taken into account. To prohibit any of these mismatch + * contributions to be incoorporated, just pass a negative number to both, si1 and sj1. + * In case the argument extLoop is 0, the returned energy contribution also includes + * the internal-loop-penalty of a multiloop stem with closing pair type. + * + * \see E_MLstem() + * \see E_ExtLoop() + * \note This function is threadsafe + * + * \param type The pair type of the first base pair un the stem + * \param si1 The 5'-mismatching nucleotide + * \param sj1 The 3'-mismatching nucleotide + * \param extLoop A flag that indicates whether the contribution reflects the one of an exterior loop or not + * \param P The datastructure containing scaled energy parameters + * \return The Free energy of the branch off the loop in dcal/mol + * + */ +INLINE PRIVATE int E_Stem( int type, + int si1, + int sj1, + int extLoop, + paramT *P); + +/** + *

Compute the Boltzmann weighted energy contribution of a stem branching off a loop-region

+ * This is the partition function variant of \ref E_Stem() + * \see E_Stem() + * \note This function is threadsafe + * + * \return The Boltzmann weighted energy contribution of the branch off the loop + */ +INLINE PRIVATE double exp_E_Stem(int type, + int si1, + int sj1, + int extLoop, + pf_paramT *P); + +/** + *

Compute Boltzmann weight \f$e^{-\Delta G/kT} \f$ of a hairpin loop

+ * multiply by scale[u+2] + * @see get_scaled_pf_parameters() + * @see pf_paramT + * @see E_Hairpin() + * \warning Not (really) thread safe! A threadsafe implementation will replace this function in a future release!\n + * Energy evaluation may change due to updates in global variable "tetra_loop" + * + * \param u The size of the loop (number of unpaired nucleotides) + * \param type The pair type of the base pair closing the hairpin + * \param si1 The 5'-mismatching nucleotide + * \param sj1 The 3'-mismatching nucleotide + * \param string The sequence of the loop + * \param P The datastructure containing scaled Boltzmann weights of the energy parameters + * \return The Boltzmann weight of the Hairpin-loop + */ +INLINE PRIVATE double exp_E_Hairpin( int u, + int type, + short si1, + short sj1, + const char *string, + pf_paramT *P); + +/** + *

Compute Boltzmann weight \f$e^{-\Delta G/kT} \f$ of interior loop

+ * multiply by scale[u1+u2+2] for scaling + * @see get_scaled_pf_parameters() + * @see pf_paramT + * @see E_IntLoop() + * \note This function is threadsafe + * + * \param u1 The size of the 'left'-loop (number of unpaired nucleotides) + * \param u2 The size of the 'right'-loop (number of unpaired nucleotides) + * \param type The pair type of the base pair closing the interior loop + * \param type2 The pair type of the enclosed base pair + * \param si1 The 5'-mismatching nucleotide of the closing pair + * \param sj1 The 3'-mismatching nucleotide of the closing pair + * \param sp1 The 3'-mismatching nucleotide of the enclosed pair + * \param sq1 The 5'-mismatching nucleotide of the enclosed pair + * \param P The datastructure containing scaled Boltzmann weights of the energy parameters + * \return The Boltzmann weight of the Interior-loop + */ +INLINE PRIVATE double exp_E_IntLoop(int u1, + int u2, + int type, + int type2, + short si1, + short sj1, + short sp1, + short sq1, + pf_paramT *P); + + +/* +################################# +# BEGIN OF FUNCTION DEFINITIONS # +################################# +*/ +INLINE PRIVATE int E_Hairpin(int size, int type, int si1, int sj1, const char *string, paramT *P){ + int energy; + + energy = (size <= 30) ? P->hairpin[size] : P->hairpin[30]+(int)(P->lxc*log((size)/30.)); + if (P->model_details.special_hp){ + if (size == 4) { /* check for tetraloop bonus */ + char tl[7]={0}, *ts; + strncpy(tl, string, 6); + if ((ts=strstr(P->Tetraloops, tl))) + return (P->Tetraloop_E[(ts - P->Tetraloops)/7]); + } + else if (size == 6) { + char tl[9]={0}, *ts; + strncpy(tl, string, 8); + if ((ts=strstr(P->Hexaloops, tl))) + return (energy = P->Hexaloop_E[(ts - P->Hexaloops)/9]); + } + else if (size == 3) { + char tl[6]={0,0,0,0,0,0}, *ts; + strncpy(tl, string, 5); + if ((ts=strstr(P->Triloops, tl))) { + return (P->Triloop_E[(ts - P->Triloops)/6]); + } + return (energy + (type>2 ? P->TerminalAU : 0)); + } + } + energy += P->mismatchH[type][si1][sj1]; + + return energy; +} + +INLINE PRIVATE int E_IntLoop(int n1, int n2, int type, int type_2, int si1, int sj1, int sp1, int sq1, paramT *P){ + /* compute energy of degree 2 loop (stack bulge or interior) */ + int nl, ns, energy; + energy = INF; + + if (n1>n2) { nl=n1; ns=n2;} + else {nl=n2; ns=n1;} + + if (nl == 0) + return P->stack[type][type_2]; /* stack */ + + if (ns==0) { /* bulge */ + energy = (nl<=MAXLOOP)?P->bulge[nl]: + (P->bulge[30]+(int)(P->lxc*log(nl/30.))); + if (nl==1) energy += P->stack[type][type_2]; + else { + if (type>2) energy += P->TerminalAU; + if (type_2>2) energy += P->TerminalAU; + } + return energy; + } + else { /* interior loop */ + if (ns==1) { + if (nl==1) /* 1x1 loop */ + return P->int11[type][type_2][si1][sj1]; + if (nl==2) { /* 2x1 loop */ + if (n1==1) + energy = P->int21[type][type_2][si1][sq1][sj1]; + else + energy = P->int21[type_2][type][sq1][si1][sp1]; + return energy; + } + else { /* 1xn loop */ + energy = (nl+1<=MAXLOOP)?(P->internal_loop[nl+1]) : (P->internal_loop[30]+(int)(P->lxc*log((nl+1)/30.))); + energy += MIN2(MAX_NINIO, (nl-ns)*P->ninio[2]); + energy += P->mismatch1nI[type][si1][sj1] + P->mismatch1nI[type_2][sq1][sp1]; + return energy; + } + } + else if (ns==2) { + if(nl==2) { /* 2x2 loop */ + return P->int22[type][type_2][si1][sp1][sq1][sj1];} + else if (nl==3){ /* 2x3 loop */ + energy = P->internal_loop[5]+P->ninio[2]; + energy += P->mismatch23I[type][si1][sj1] + P->mismatch23I[type_2][sq1][sp1]; + return energy; + } + + } + { /* generic interior loop (no else here!)*/ + energy = (n1+n2<=MAXLOOP)?(P->internal_loop[n1+n2]) : (P->internal_loop[30]+(int)(P->lxc*log((n1+n2)/30.))); + + energy += MIN2(MAX_NINIO, (nl-ns)*P->ninio[2]); + + energy += P->mismatchI[type][si1][sj1] + P->mismatchI[type_2][sq1][sp1]; + } + } + return energy; +} + +INLINE PRIVATE int E_Stem(int type, int si1, int sj1, int extLoop, paramT *P){ + int energy = 0; + int d5 = (si1 >= 0) ? P->dangle5[type][si1] : 0; + int d3 = (sj1 >= 0) ? P->dangle3[type][sj1] : 0; + + if(type > 2) + energy += P->TerminalAU; + + if(si1 >= 0 && sj1 >= 0) + energy += (extLoop) ? P->mismatchExt[type][si1][sj1] : P->mismatchM[type][si1][sj1]; + else + energy += d5 + d3; + + if(!extLoop) energy += P->MLintern[type]; + return energy; +} + +INLINE PRIVATE int E_ExtLoop(int type, int si1, int sj1, paramT *P){ + int energy = 0; + if(si1 >= 0 && sj1 >= 0){ + energy += P->mismatchExt[type][si1][sj1]; + } + else if (si1 >= 0){ + energy += P->dangle5[type][si1]; + } + else if (sj1 >= 0){ + energy += P->dangle3[type][sj1]; + } + + if(type > 2) + energy += P->TerminalAU; + + return energy; +} + +INLINE PRIVATE int E_MLstem(int type, int si1, int sj1, paramT *P){ + int energy = 0; + if(si1 >= 0 && sj1 >= 0){ + energy += P->mismatchM[type][si1][sj1]; + } + else if (si1 >= 0){ + energy += P->dangle5[type][si1]; + } + else if (sj1 >= 0){ + energy += P->dangle3[type][sj1]; + } + + if(type > 2) + energy += P->TerminalAU; + + energy += P->MLintern[type]; + + return energy; +} + +INLINE PRIVATE double exp_E_Hairpin(int u, int type, short si1, short sj1, const char *string, pf_paramT *P){ + double q, kT; + kT = P->kT; /* kT in cal/mol */ + + if(u <= 30) + q = P->exphairpin[u]; + else + q = P->exphairpin[30] * exp( -(P->lxc*log( u/30.))*10./kT); + + if(u < 3) return q; /* should only be the case when folding alignments */ + + if(P->model_details.special_hp){ + if(u==4) { + char tl[7]={0,0,0,0,0,0,0}, *ts; + strncpy(tl, string, 6); + if ((ts=strstr(P->Tetraloops, tl))){ + if(type != 7) + return (P->exptetra[(ts-P->Tetraloops)/7]); + else + q *= P->exptetra[(ts-P->Tetraloops)/7]; + } + } + if (u==6) { + char tl[9]={0,0,0,0,0,0,0,0,0}, *ts; + strncpy(tl, string, 8); + if ((ts=strstr(P->Hexaloops, tl))) + return (P->exphex[(ts-P->Hexaloops)/9]); + } + if (u==3) { + char tl[6]={0,0,0,0,0,0}, *ts; + strncpy(tl, string, 5); + if ((ts=strstr(P->Triloops, tl))) + return (P->exptri[(ts-P->Triloops)/6]); + if (type>2) + return q *= P->expTermAU; + } + } + /* no mismatches for tri-loops */ + q *= P->expmismatchH[type][si1][sj1]; + + return q; +} + +INLINE PRIVATE double exp_E_IntLoop(int u1, int u2, int type, int type2, short si1, short sj1, short sp1, short sq1, pf_paramT *P){ + int ul, us, no_close = 0; + double z = 0.; + + if ((no_closingGU) && ((type2==3)||(type2==4)||(type==3)||(type==4))) + no_close = 1; + + if (u1>u2) { ul=u1; us=u2;} + else {ul=u2; us=u1;} + + if (ul==0) /* stack */ + z = P->expstack[type][type2]; + else if(!no_close){ + if (us==0) { /* bulge */ + z = P->expbulge[ul]; + if (ul==1) z *= P->expstack[type][type2]; + else { + if (type>2) z *= P->expTermAU; + if (type2>2) z *= P->expTermAU; + } + return z; + } + else if (us==1) { + if (ul==1){ /* 1x1 loop */ + return P->expint11[type][type2][si1][sj1]; + } + if (ul==2) { /* 2x1 loop */ + if (u1==1) + return P->expint21[type][type2][si1][sq1][sj1]; + else + return P->expint21[type2][type][sq1][si1][sp1]; + } + else { /* 1xn loop */ + z = P->expinternal[ul+us] * P->expmismatch1nI[type][si1][sj1] * P->expmismatch1nI[type2][sq1][sp1]; + return z * P->expninio[2][ul-us]; + } + } + else if (us==2) { + if(ul==2) /* 2x2 loop */ + return P->expint22[type][type2][si1][sp1][sq1][sj1]; + else if(ul==3){ /* 2x3 loop */ + z = P->expinternal[5]*P->expmismatch23I[type][si1][sj1]*P->expmismatch23I[type2][sq1][sp1]; + return z * P->expninio[2][1]; + } + } + /* generic interior loop (no else here!)*/ + z = P->expinternal[ul+us] * P->expmismatchI[type][si1][sj1] * P->expmismatchI[type2][sq1][sp1]; + return z * P->expninio[2][ul-us]; + + } + return z; +} + +INLINE PRIVATE double exp_E_Stem(int type, int si1, int sj1, int extLoop, pf_paramT *P){ + double energy = 1.0; + double d5 = (si1 >= 0) ? P->expdangle5[type][si1] : 1.; + double d3 = (sj1 >= 0) ? P->expdangle3[type][sj1] : 1.; + + if(type > 2) + energy *= P->expTermAU; + + if(si1 >= 0 && sj1 >= 0) + energy *= (extLoop) ? P->expmismatchExt[type][si1][sj1] : P->expmismatchM[type][si1][sj1]; + else + energy *= d5 * d3; + + if(!extLoop) energy *= P->expMLintern[type]; + return energy; +} + +INLINE PRIVATE double exp_E_MLstem(int type, int si1, int sj1, pf_paramT *P){ + double energy = 1.0; + if(si1 >= 0 && sj1 >= 0){ + energy *= P->expmismatchM[type][si1][sj1]; + } + else if(si1 >= 0){ + energy *= P->expdangle5[type][si1]; + } + else if(sj1 >= 0){ + energy *= P->expdangle3[type][sj1]; + } + + if(type > 2) + energy *= P->expTermAU; + + energy *= P->expMLintern[type]; + return energy; +} + +INLINE PRIVATE double exp_E_ExtLoop(int type, int si1, int sj1, pf_paramT *P){ + double energy = 1.0; + if(si1 >= 0 && sj1 >= 0){ + energy *= P->expmismatchExt[type][si1][sj1]; + } + else if(si1 >= 0){ + energy *= P->expdangle5[type][si1]; + } + else if(sj1 >= 0){ + energy *= P->expdangle3[type][sj1]; + } + + if(type > 2) + energy *= P->expTermAU; + + return energy; +} + +INLINE PRIVATE int E_IntLoop_Co(int type, int type_2, int i, int j, int p, int q, int cutpoint, short si1, short sj1, short sp1, short sq1, int dangles, paramT *P){ + int energy = 0; + if(type > 2) energy += P->TerminalAU; + if(type_2 > 2) energy += P->TerminalAU; + + if(!dangles) return energy; + + int ci = (i>=cutpoint)||((i+1)=cutpoint)||(j=cutpoint)||(p=cutpoint)||((q+1)dangle3[type][si1] : 0; + int d5 = cj ? P->dangle5[type][sj1] : 0; + int d5_2 = cp ? P->dangle5[type_2][sp1] : 0; + int d3_2 = cq ? P->dangle3[type_2][sq1] : 0; + + int tmm = (cj && ci) ? P->mismatchExt[type][sj1][si1] : d5 + d3; + int tmm_2 = (cp && cq) ? P->mismatchExt[type_2][sp1][sq1] : d5_2 + d3_2; + + if(dangles == 2) return energy + tmm + tmm_2; + + /* now we may have non-double dangles only */ + if(i+2 < p){ + if(q+2 < j){ energy += tmm + tmm_2;} + else if(q+2 == j){ energy += (cj && cq) ? MIN2(tmm + d5_2, tmm_2 + d3) : tmm + tmm_2;} + else energy += d3 + d5_2; + } + else if(i+2 == p){ + if(q+2 < j){ energy += (ci && cp) ? MIN2(tmm + d3_2, tmm_2 + d5) : tmm + tmm_2;} + else if(q+2 == j){ + energy += MIN2(tmm, MIN2(tmm_2, MIN2(d5 + d5_2, d3 + d3_2))); + } + else energy += MIN2(d3, d5_2); + } + else{ + if(q+2 < j){ energy += d5 + d3_2;} + else if(q+2 == j){ energy += MIN2(d5, d3_2);} + } + return energy; +} + +#endif diff --git a/include/naview.h b/include/naview.h new file mode 100644 --- /dev/null +++ b/include/naview.h @@ -0,0 +1,16 @@ +#ifndef __VIENNA_RNA_PACKAGE_NAVIEW_H__ +#define __VIENNA_RNA_PACKAGE_NAVIEW_H__ + +/** + * \file naview.h + * + */ + +/** + * + */ +int naview_xy_coordinates(short *pair_table, + float *X, + float *Y); + +#endif diff --git a/include/pair_mat.h b/include/pair_mat.h new file mode 100644 --- /dev/null +++ b/include/pair_mat.h @@ -0,0 +1,148 @@ +#include +#include "utils.h" +#include "fold_vars.h" + +#define NBASES 8 +/*@notnull@*/ + +static const char Law_and_Order[] = "_ACGUTXKI"; +static int BP_pair[NBASES][NBASES]= +/* _ A C G U X K I */ +{{ 0, 0, 0, 0, 0, 0, 0, 0}, + { 0, 0, 0, 0, 5, 0, 0, 5}, + { 0, 0, 0, 1, 0, 0, 0, 0}, + { 0, 0, 2, 0, 3, 0, 0, 0}, + { 0, 6, 0, 4, 0, 0, 0, 6}, + { 0, 0, 0, 0, 0, 0, 2, 0}, + { 0, 0, 0, 0, 0, 1, 0, 0}, + { 0, 6, 0, 0, 5, 0, 0, 0}}; + +#define MAXALPHA 20 /* maximal length of alphabet */ + +static short alias[MAXALPHA+1]; +static int pair[MAXALPHA+1][MAXALPHA+1]; +/* rtype[pair[i][j]]:=pair[j][i] */ +static int rtype[8] = {0, 2, 1, 4, 3, 6, 5, 7}; + +#ifdef _OPENMP +#pragma omp threadprivate(Law_and_Order, BP_pair, alias, pair, rtype) +#endif + +/* for backward compatibility */ +#define ENCODE(c) encode_char(c) + +static int encode_char(char c) { + /* return numerical representation of base used e.g. in pair[][] */ + int code; + if (energy_set>0) code = (int) (c-'A')+1; + else { + const char *pos; + pos = strchr(Law_and_Order, c); + if (pos==NULL) code=0; + else code = (int) (pos-Law_and_Order); + if (code>5) code = 0; + if (code>4) code--; /* make T and U equivalent */ + } + return code; +} + +/*@+boolint +charint@*/ +/*@null@*/ +extern char *nonstandards; +extern void nrerror(const char message[]); +static void make_pair_matrix(void) +{ + int i,j; + + if (energy_set==0) { + for (i=0; i<5; i++) alias[i] = (short) i; + alias[5] = 3; /* X <-> G */ + alias[6] = 2; /* K <-> C */ + alias[7] = 0; /* I <-> default base '@' */ + for (i=0; i G */ + alias[i++] = 2; /* B <-> C */ + } + for (i=1; i GC */ + i++; + pair[i][i-1] = 1; /* BA <-> CG */ + } + } + else if (energy_set==2) { + for (i=1; i A*/ + alias[i++] = 4; /* B <-> U */ + } + for (i=1; i AU */ + i++; + pair[i][i-1] = 6; /* BA <-> UA */ + } + } + else if (energy_set==3) { + for (i=1; i G */ + alias[i++] = 2; /* B <-> C */ + alias[i++] = 1; /* C <-> A */ + alias[i++] = 4; /* D <-> U */ + } + for (i=1; i GC */ + i++; + pair[i][i-1] = 1; /* BA <-> CG */ + i++; + pair[i][i+1] = 5; /* CD <-> AU */ + i++; + pair[i][i-1] = 6; /* DC <-> UA */ + } + } + else nrerror("What energy_set are YOU using??"); + for (i=0; i<=MAXALPHA; i++) { + for (j=0; j<=MAXALPHA; j++) + rtype[pair[i][j]] = pair[j][i]; + } + } +} + +static short *encode_sequence(const char *sequence, short how){ + unsigned int i,l = (unsigned int)strlen(sequence); + short *S = (short *) space(sizeof(short)*(l+2)); + + switch(how){ + /* standard encoding as always used for S */ + case 0: for(i=1; i<=l; i++) /* make numerical encoding of sequence */ + S[i]= (short) encode_char(toupper(sequence[i-1])); + S[l+1] = S[1]; + S[0] = (short) l; + break; + /* encoding for mismatches of nostandard bases (normally used for S1) */ + case 1: for(i=1; i<=l; i++) + S[i] = alias[(short) encode_char(toupper(sequence[i-1]))]; + S[l+1] = S[1]; + S[0] = S[l]; + break; + } + + return S; +} diff --git a/include/params.h b/include/params.h new file mode 100644 --- /dev/null +++ b/include/params.h @@ -0,0 +1,134 @@ +#ifndef __VIENNA_RNA_PACKAGE_PARAMS_H__ +#define __VIENNA_RNA_PACKAGE_PARAMS_H__ + +#include "energy_const.h" +#include "data_structures.h" + +#ifdef __GNUC__ +#define DEPRECATED(func) func __attribute__ ((deprecated)) +#else +#define DEPRECATED(func) func +#endif + +/** + * \addtogroup energy_parameters + * \brief All relevant functions to retrieve and copy precalculated energy parameter sets as well as + * reading/writing the energy parameter set from/to file(s). + * + * This module covers all relevant functions for precalculation of the energy parameters + * necessary for the folding routines provided by RNAlib. Furthermore, the energy parameter set + * in the RNAlib can be easily exchanged by a user-defined one. It is also possible to write the + * current energy parameter set into a text file. + * @{ + * + * \file params.h + */ + +/** + * \brief Get precomputed energy contributions for all the known loop types + * + * \note OpenMP: This function relies on several global model settings variables and thus is + * not to be considered threadsafe. See get_scaled_parameters() for a completely threadsafe + * implementation. + * + * \return A set of precomputed energy contributions + */ +paramT *scale_parameters(void); + +/** + * \brief Get precomputed energy contributions for all the known loop types + * + * Call this function to retrieve precomputed energy contributions, i.e. scaled + * according to the temperature passed. Furthermore, this function assumes a + * data structure that contains the model details as well, such that subsequent + * folding recursions are able to retrieve the correct model settings + * + * \see #model_detailsT, set_model_details() + * + * \param temperature The temperature in degrees Celcius + * \param md The model details + * \return precomputed energy contributions and model settings + */ +paramT *get_scaled_parameters(double temperature, + model_detailsT md); + +paramT *get_parameter_copy(paramT *par); + +/** + * get a datastructure of type \ref pf_paramT which contains + * the Boltzmann weights of several energy parameters scaled + * according to the current temperature + * \return The datastructure containing Boltzmann weights for use in partition function calculations + */ +pf_paramT *get_scaled_pf_parameters(void); + +/** + * \brief Get precomputed Boltzmann factors of the loop type + * dependent energy contributions with independent thermodynamic + * temperature + * + * This function returns a data structure that contains + * all necessary precalculated Boltzmann factors for each + * loop type contribution.
+ * In contrast to get_scaled_pf_parameters(), this function + * enables setting of independent temperatures for both, the + * individual energy contributions as well as the thermodynamic + * temperature used in + * \f$ exp(-\Delta G / kT) \f$ + * + * \see get_scaled_pf_parameters(), get_boltzmann_factor_copy() + * + * \param temperature The temperature in degrees Celcius used for (re-)scaling the energy contributions + * \param betaScale A scaling value that is used as a multiplication factor for the absolute + * temperature of the system + * \param md The model details to be used + * \param pf_scale The scaling factor for the Boltzmann factors + * \return A set of precomputed Boltzmann factors + */ +pf_paramT *get_boltzmann_factors( double temperature, + double betaScale, + model_detailsT md, + double pf_scale); + +/** + * \brief Get a copy of already precomputed Boltzmann factors + * + * \see get_boltzmann_factors(), get_scaled_pf_parameters() + * + * \param parameters The input data structure that shall be copied + * \return A copy of the provided Boltzmann factor dataset + */ +pf_paramT *get_boltzmann_factor_copy(pf_paramT *parameters); + +/** + * \brief Get precomputed Boltzmann factors of the loop type + * dependent energy contributions (alifold variant) + * + */ +pf_paramT *get_scaled_alipf_parameters(unsigned int n_seq); + +/** + * \brief Get precomputed Boltzmann factors of the loop type + * dependent energy contributions (alifold variant) with + * independent thermodynamic temperature + * + */ +PUBLIC pf_paramT *get_boltzmann_factors_ali(unsigned int n_seq, + double temperature, + double betaScale, + model_detailsT md, + double pf_scale); + +/** + * @} + */ + +DEPRECATED(paramT *copy_parameters(void)); +DEPRECATED(paramT *set_parameters(paramT *dest)); +DEPRECATED(pf_paramT *scale_pf_parameters(void)); +DEPRECATED(pf_paramT *copy_pf_param(void)); +DEPRECATED(pf_paramT *set_pf_param(paramT *dest)); + + + +#endif diff --git a/include/part_func.h b/include/part_func.h new file mode 100644 --- /dev/null +++ b/include/part_func.h @@ -0,0 +1,443 @@ +#ifndef __VIENNA_RNA_PACKAGE_PART_FUNC_H__ +#define __VIENNA_RNA_PACKAGE_PART_FUNC_H__ + +#include "data_structures.h" + +#ifdef __GNUC__ +#define DEPRECATED(func) func __attribute__ ((deprecated)) +#else +#define DEPRECATED(func) func +#endif + + +/** + * \addtogroup pf_fold + * \brief This section provides information about all functions and variables related to + * the calculation of the partition function and base pair probabilities. + * + * Instead of the minimum free energy structure the partition function of all possible structures + * and from that the pairing probability for every possible pair can be calculated, using a dynamic + * programming algorithm as described in \cite mccaskill:1990. + * + * @{ + * \file part_func.h + * \brief Partition function of single RNA sequences + * + * This file includes (almost) all function declarations within the RNAlib that are related to + * Partion function folding... + * @} + */ + +/** + * \brief Flag indicating that auxilary arrays are needed throughout the computations. This is essential for stochastic backtracking + * + * Set this variable to 1 prior to a call of pf_fold() to ensure that all matrices needed for stochastic backtracking + * are filled in the forward recursions + * + * \ingroup subopt_stochbt + * + * \see pbacktrack(), pbacktrack_circ + */ +extern int st_back; + +/* +################################################# +# PARTITION FUNCTION COMPUTATION # +################################################# +*/ + +/** + * \brief Compute the partition function \f$Q\f$ for a given RNA sequence + * + * If \a structure is not a NULL pointer on input, it contains on + * return a string consisting of the letters " . , | { } ( ) " denoting + * bases that are essentially unpaired, weakly paired, strongly paired without + * preference, weakly upstream (downstream) paired, or strongly up- + * (down-)stream paired bases, respectively. + * If #fold_constrained is not 0, the \a structure string is + * interpreted on input as a list of constraints for the folding. The + * character "x" marks bases that must be unpaired, matching brackets " ( ) " + * denote base pairs, all other characters are ignored. Any pairs + * conflicting with the constraint will be forbidden. This is usually sufficient + * to ensure the constraints are honored. + * If tha parameter calculate_bppm is set to 0 base pairing probabilities will not + * be computed (saving CPU time), otherwise after calculations took place #pr will + * contain the probability that bases \a i and \a j pair. + * + * \ingroup pf_fold + * + * \note The global array #pr is deprecated and the user who wants the calculated + * base pair probabilities for further computations is advised to use the function + * export_bppm() + * \post After successful run the hidden folding matrices are filled with the appropriate Boltzmann factors. + * Depending on whether the global variable #do_backtrack was set the base pair probabilities are already + * computed and may be accessed for further usage via the export_bppm() function. + * A call of free_pf_arrays() will free all memory allocated by this function. + * Successive calls will first free previously allocated memory before starting the computation. + * \see pf_fold(), pf_circ_fold(), bppm_to_structure(), export_bppm(), get_boltzmann_factors(), free_pf_arrays() + * \param[in] sequence The RNA sequence input + * \param[in,out] structure A pointer to a char array where a base pair probability information can be stored in a + * pseudo-dot-bracket notation (may be NULL, too) + * \param[in] parameters Data structure containing the precalculated Boltzmann factors + * \param[in] calculate_bppm Switch to Base pair probability calculations on/off (0==off) + * \param[in] is_constrained Switch to indicate that a structure contraint is passed via the structure argument (0==off) + * \param[in] is_circular Switch to (de-)activate postprocessing steps in case RNA sequence is circular (0==off) + * \return The Gibbs free energy of the ensemble (\f$G = -RT \cdot \log(Q) \f$) in kcal/mol + */ +float pf_fold_par( const char *sequence, + char *structure, + pf_paramT *parameters, + int calculate_bppm, + int is_constrained, + int is_circular); + +/** + * \brief Compute the partition function \f$Q\f$ of an RNA sequence + * + * If \a structure is not a NULL pointer on input, it contains on + * return a string consisting of the letters " . , | { } ( ) " denoting + * bases that are essentially unpaired, weakly paired, strongly paired without + * preference, weakly upstream (downstream) paired, or strongly up- + * (down-)stream paired bases, respectively. + * If #fold_constrained is not 0, the \a structure string is + * interpreted on input as a list of constraints for the folding. The + * character "x" marks bases that must be unpaired, matching brackets " ( ) " + * denote base pairs, all other characters are ignored. Any pairs + * conflicting with the constraint will be forbidden. This is usually sufficient + * to ensure the constraints are honored. + * If #do_backtrack has been set to 0 base pairing probabilities will not + * be computed (saving CPU time), otherwise #pr will contain the probability + * that bases \a i and \a j pair. + * + * \ingroup pf_fold + * + * \note The global array #pr is deprecated and the user who wants the calculated + * base pair probabilities for further computations is advised to use the function + * export_bppm(). + * \note \b OpenMP: + * This function is not entirely threadsafe. While the recursions are working on their + * own copies of data the model details for the recursions are determined from the global + * settings just before entering the recursions. Consider using pf_fold_par() for a + * really threadsafe implementation. + * \pre This function takes its model details from the global variables provided in \e RNAlib + * \post After successful run the hidden folding matrices are filled with the appropriate Boltzmann factors. + * Depending on whether the global variable #do_backtrack was set the base pair probabilities are already + * computed and may be accessed for further usage via the export_bppm() function. + * A call of free_pf_arrays() will free all memory allocated by this function. + * Successive calls will first free previously allocated memory before starting the computation. + * \see pf_fold_par(), pf_circ_fold(), bppm_to_structure(), export_bppm() + * \param sequence The RNA sequence input + * \param structure A pointer to a char array where a base pair probability information can be stored in a pseudo-dot-bracket notation (may be NULL, too) + * \return The Gibbs free energy of the ensemble (\f$G = -RT \cdot \log(Q) \f$) in kcal/mol + */ +float pf_fold(const char *sequence, + char *structure); + +/** + * \brief Compute the partition function of a circular RNA sequence + * + * \ingroup pf_fold + * + * \note The global array #pr is deprecated and the user who wants the calculated + * base pair probabilities for further computations is advised to use the function + * export_bppm(). + * \note \b OpenMP: + * This function is not entirely threadsafe. While the recursions are working on their + * own copies of data the model details for the recursions are determined from the global + * settings just before entering the recursions. Consider using pf_fold_par() for a + * really threadsafe implementation. + * \pre This function takes its model details from the global variables provided in \e RNAlib + * \post After successful run the hidden folding matrices are filled with the appropriate Boltzmann factors. + * Depending on whether the global variable #do_backtrack was set the base pair probabilities are already + * computed and may be accessed for further usage via the export_bppm() function. + * A call of free_pf_arrays() will free all memory allocated by this function. + * Successive calls will first free previously allocated memory before starting the computation. + * \see pf_fold_par(), pf_fold() + * \param[in] sequence The RNA sequence input + * \param[in,out] structure A pointer to a char array where a base pair probability information can be + * stored in a pseudo-dot-bracket notation (may be NULL, too) + * \return The Gibbs free energy of the ensemble (\f$G = -RT \cdot \log(Q) \f$) in kcal/mol + */ +float pf_circ_fold( const char *sequence, + char *structure); + +/** + * \brief Sample a secondary structure from the Boltzmann ensemble according its probability\n + * + * \ingroup subopt_stochbt + * \pre pf_fold_par() or pf_fold() have to be called first to fill the partition function matrices + * + * \param sequence The RNA sequence + * \return A sampled secondary structure in dot-bracket notation + */ +char *pbacktrack(char *sequence); + +/** + * \brief Sample a secondary structure of a circular RNA from the Boltzmann ensemble according its probability + * + * This function does the same as \ref pbacktrack() but assumes the RNA molecule to be circular + * + * \ingroup subopt_stochbt + * \pre pf_fold_par() or pf_fold_circ() have to be called first to fill the partition function matrices + * + * \param sequence The RNA sequence + * \return A sampled secondary structure in dot-bracket notation + */ +char *pbacktrack_circ(char *sequence); + +/** + * \brief Free arrays for the partition function recursions + * + * Call this function if you want to free all allocated memory associated with + * the partition function forward recursion. + * \note Successive calls of pf_fold(), pf_circ_fold() already check if they should free + * any memory from a previous run. + * \note OpenMP notice:
+ * This function should be called before leaving a thread in order to avoid leaking memory + * + * \ingroup pf_fold + * + * \post All memory allocated by pf_fold_par(), pf_fold() or pf_circ_fold() will be free'd + * \see pf_fold_par(), pf_fold(), pf_circ_fold() + */ +void free_pf_arrays(void); + +/** + * \brief Recalculate energy parameters + * + * Call this function to recalculate the pair matrix and energy parameters + * after a change in folding parameters like #temperature + * + * \ingroup pf_fold + * + */ +void update_pf_params(int length); + +/** + * \brief Recalculate energy parameters + * + * \ingroup pf_fold + * + */ +void update_pf_params_par(int length, pf_paramT *parameters); + +/** + * \brief Get a pointer to the base pair probability array + * \ingroup pf_fold + * + * Accessing the base pair probabilities for a pair (i,j) is achieved by + * \code + * FLT_OR_DBL *pr = export_bppm(); + * pr_ij = pr[iindx[i]-j]; + * \endcode + * + * \pre Call pf_fold_par(), pf_fold() or pf_circ_fold() first to fill the base pair probability array + * + * \see pf_fold(), pf_circ_fold(), get_iindx() + * + * \return A pointer to the base pair probability array + */ +FLT_OR_DBL *export_bppm(void); + +/* +################################################# +# OTHER PARTITION FUNCTION RELATED DECLARATIONS # +################################################# +*/ + +/** + * \brief Create a plist from a probability matrix + * + * The probability matrix given is parsed and all pair probabilities above + * the given threshold are used to create an entry in the plist + * + * The end of the plist is marked by sequence positions i as well as j + * equal to 0. This condition should be used to stop looping over its + * entries + * + * \note This function is threadsafe + * \ingroup pf_fold + * \param[out] pl A pointer to the plist that is to be created + * \param[in] probs The probability matrix used for creting the plist + * \param[in] length The length of the RNA sequence + * \param[in] cutoff The cutoff value + */ +void assign_plist_from_pr( plist **pl, + FLT_OR_DBL *probs, + int length, + double cutoff); + +/* this doesn't work if free_pf_arrays() is called before */ +void assign_plist_gquad_from_pr(plist **pl, + int length, + double cut_off); + +char *get_centroid_struct_gquad_pr(int length, + double *dist); + +/** + * \brief Get the pointers to (almost) all relavant computation arrays used in partition function computation + * + * \ingroup pf_fold + * \pre In order to assign meaningful pointers, you have to call pf_fold_par() or pf_fold() first! + * \see pf_fold_par(), pf_fold(), pf_circ_fold() + * \param[out] S_p A pointer to the 'S' array (integer representation of nucleotides) + * \param[out] S1_p A pointer to the 'S1' array (2nd integer representation of nucleotides) + * \param[out] ptype_p A pointer to the pair type matrix + * \param[out] qb_p A pointer to the QB matrix + * \param[out] qm_p A pointer to the QM matrix + * \param[out] q1k_p A pointer to the 5' slice of the Q matrix (\f$q1k(k) = Q(1, k)\f$) + * \param[out] qln_p A pointer to the 3' slice of the Q matrix (\f$qln(l) = Q(l, n)\f$) + * \return Non Zero if everything went fine, 0 otherwise + */ +int get_pf_arrays(short **S_p, + short **S1_p, + char **ptype_p, + FLT_OR_DBL **qb_p, + FLT_OR_DBL **qm_p, + FLT_OR_DBL **q1k_p, + FLT_OR_DBL **qln_p); + +/** + * \brief Get the free energy of a subsequence from the q[] array + */ +double get_subseq_F(int i, int j); + +/** + * \brief Get the centroid structure of the ensemble + * + * This function is a threadsafe replacement for \ref centroid() with a 'plist' input + * + * The centroid is the structure with the minimal average distance to all other structures + * \n \f$ = \sum_{(i,j) \in S} (1-p_{ij}) + \sum_{(i,j) \notin S} p_{ij} \f$ \n + * Thus, the centroid is simply the structure containing all pairs with \f$p_ij>0.5\f$ + * The distance of the centroid to the ensemble is written to the memory adressed by \a dist. + * + * \ingroup centroid_fold + * \param[in] length The length of the sequence + * \param[out] dist A pointer to the distance variable where the centroid distance will be written to + * \param[in] pl A pair list containing base pair probability information about the ensemble + * \return The centroid structure of the ensemble in dot-bracket notation + */ +char *get_centroid_struct_pl(int length, + double *dist, + plist *pl); + +/** + * \brief Get the centroid structure of the ensemble + * + * This function is a threadsafe replacement for \ref centroid() with a probability array input + * + * The centroid is the structure with the minimal average distance to all other structures + * \n \f$ = \sum_{(i,j) \in S} (1-p_{ij}) + \sum_{(i,j) \notin S} p_{ij} \f$ \n + * Thus, the centroid is simply the structure containing all pairs with \f$p_ij>0.5\f$ + * The distance of the centroid to the ensemble is written to the memory adressed by \a dist. + * + * \ingroup centroid_fold + * \param[in] length The length of the sequence + * \param[out] dist A pointer to the distance variable where the centroid distance will be written to + * \param[in] pr A upper triangular matrix containing base pair probabilities (access via iindx \ref get_iindx() ) + * \return The centroid structure of the ensemble in dot-bracket notation + */ +char *get_centroid_struct_pr(int length, + double *dist, + FLT_OR_DBL *pr); + +/** + * \brief Get the mean base pair distance of the last partition function computation + * + * \note To ensure thread-safety, use the function mean_bp_distance_pr() instead! + * + * \ingroup pf_fold + * + * \see mean_bp_distance_pr() + * + * \param length + * \return mean base pair distance in thermodynamic ensemble + */ +double mean_bp_distance(int length); + +/** + * \brief Get the mean base pair distance in the thermodynamic ensemble + * + * This is a threadsafe implementation of \ref mean_bp_dist() ! + * + * \f$ = \sum_{a,b} p_a p_b d(S_a,S_b)\f$\n + * this can be computed from the pair probs \f$p_ij\f$ as\n + * \f$ = \sum_{ij} p_{ij}(1-p_{ij})\f$ + * + * \note This function is threadsafe + * + * \ingroup pf_fold + * + * \param length The length of the sequence + * \param pr The matrix containing the base pair probabilities + * \return The mean pair distance of the structure ensemble + */ +double mean_bp_distance_pr(int length, + FLT_OR_DBL *pr); + +/** + * \brief Create a dot-bracket like structure string from base pair probability matrix + */ +void bppm_to_structure(char *structure, + FLT_OR_DBL *pr, + unsigned int length); + +plist *stackProb(double cutoff); + +/** + * \brief Get a pseudo dot bracket notation for a given probability information + */ +char bppm_symbol(const float *x); + + +/* +################################################# +# DEPRECATED FUNCTIONS # +################################################# +*/ + +/** + * \brief Allocate space for pf_fold() + * + * \deprecated This function is obsolete and will be removed soon! + */ +DEPRECATED(void init_pf_fold(int length)); + +/** + * \deprecated This function is deprecated and should not be used anymore as it is not threadsafe! + * \see get_centroid_struct_pl(), get_centroid_struct_pr() + */ +DEPRECATED(char *centroid(int length, + double *dist)); /* mean pair distance of ensemble */ + +/** + * get the mean pair distance of ensemble + * + * \deprecated This function is not threadsafe and should not be used anymore. Use \ref mean_bp_distance() instead! + */ +DEPRECATED(double mean_bp_dist(int length)); + +/** + * \deprecated Use \ref exp_E_IntLoop() from loop_energies.h instead + */ +DEPRECATED(double expLoopEnergy(int u1, + int u2, + int type, + int type2, + short si1, + short sj1, + short sp1, + short sq1)); + +/** + * \deprecated Use exp_E_Hairpin() from loop_energies.h instead + */ +DEPRECATED(double expHairpinEnergy( int u, + int type, + short si1, + short sj1, + const char *string)); + +#endif diff --git a/include/part_func_co.h b/include/part_func_co.h new file mode 100644 --- /dev/null +++ b/include/part_func_co.h @@ -0,0 +1,235 @@ +#ifndef __VIENNA_RNA_PACKAGE_PART_FUNC_CO_H__ +#define __VIENNA_RNA_PACKAGE_PART_FUNC_CO_H__ + +#include "data_structures.h" + +#ifdef __GNUC__ +#define DEPRECATED(func) func __attribute__ ((deprecated)) +#else +#define DEPRECATED(func) func +#endif + +/** + * \addtogroup pf_cofold + * \brief Partition Function Cofolding + * + * To simplify the implementation the partition function computation is done + * internally in a null model that does not include the duplex initiation + * energy, i.e. the entropic penalty for producing a dimer from two + * monomers). The resulting free energies and pair probabilities are initially + * relative to that null model. In a second step the free energies can be + * corrected to include the dimerization penalty, and the pair probabilities + * can be divided into the conditional pair probabilities given that a re + * dimer is formed or not formed. See \cite bernhart:2006 for further details. + * @{ + * \file part_func_co.h + * + * \brief Partition function for two RNA sequences + * + * As for folding one RNA molecule, this computes the partition function + * of all possible structures and the base pair probabilities. Uses the + * same global #pf_scale variable to avoid overflows. + * + * To simplify the implementation the partition function computation is done + * internally in a null model that does not include the duplex initiation + * energy, i.e. the entropic penalty for producing a dimer from two + * monomers). The resulting free energies and pair probabilities are initially + * relative to that null model. In a second step the free energies can be + * corrected to include the dimerization penalty, and the pair probabilities + * can be divided into the conditional pair probabilities given that a re + * dimer is formed or not formed. + * + * After computing the partition functions of all possible dimeres one + * can compute the probabilities of base pairs, the concentrations out of + * start concentrations and sofar and soaway. + * + * Dimer formation is inherently concentration dependent. Given the free + * energies of the monomers A and B and dimers AB, AA, and BB one can compute + * the equilibrium concentrations, given input concentrations of A and B, see + * e.g. Dimitrov & Zuker (2004) + */ + +/** + * \brief Toggles no intrabp in 2nd mol + */ +extern int mirnatog; + +/** + * \brief Free energies of the two monomers + */ +extern double F_monomer[2]; + +/** + * \brief Calculate partition function and base pair probabilities + * + * This is the cofold partition function folding. The second molecule starts + * at the #cut_point nucleotide. + * + * \note OpenMP: Since this function relies on the global parameters + * #do_backtrack, #dangles, #temperature and #pf_scale it is not + * threadsafe according to concurrent changes in these variables! + * Use co_pf_fold_par() instead to circumvent this issue. + * + * \see co_pf_fold_par() + * + * \param sequence Concatenated RNA sequences + * \param structure Will hold the structure or constraints + * \return cofoldF structure containing a set of energies needed for + * concentration computations. + */ +cofoldF co_pf_fold( char *sequence, + char *structure); + +/** + * \brief Calculate partition function and base pair probabilities + * + * This is the cofold partition function folding. The second molecule starts + * at the #cut_point nucleotide. + * + * \see get_boltzmann_factors(), co_pf_fold() + * + * \param sequence Concatenated RNA sequences + * \param structure Pointer to the structure constraint + * \param parameters Data structure containing the precalculated Boltzmann factors + * \param calculate_bppm Switch to turn Base pair probability calculations on/off (0==off) + * \param is_constrained Switch to indicate that a structure contraint is passed via the + * structure argument (0==off) + * \return cofoldF structure containing a set of energies needed for + * concentration computations. + */ +cofoldF co_pf_fold_par( char *sequence, + char *structure, + pf_paramT *parameters, + int calculate_bppm, + int is_constrained); + +/** + * \brief Get a pointer to the base pair probability array + * + * Accessing the base pair probabilities for a pair (i,j) is achieved by + * \verbatim FLT_OR_DBL *pr = export_bppm(); pr_ij = pr[iindx[i]-j]; \endverbatim + * + * \see get_iindx() + * \return A pointer to the base pair probability array + */ +FLT_OR_DBL *export_co_bppm(void); + +/** + * \brief Free the memory occupied by co_pf_fold() + */ +void free_co_pf_arrays(void); + +/** + * \brief Recalculate energy parameters + * + * This function recalculates all energy parameters given + * the current model settings. + * + * \note This function relies on the global variables #pf_scale, #dangles and + * #temperature. Thus it might not be threadsafe in certain situations. + * Use update_co_pf_params_par() instead. + * + * \see get_boltzmann_factors(), update_co_pf_params_par() + * + * \param length Length of the current RNA sequence + */ +void update_co_pf_params(int length); + +/** + * \brief Recalculate energy parameters + * + * This function recalculates all energy parameters given + * the current model settings. + * It's second argument can either be NULL or a data structure + * containing the precomputed Boltzmann factors. In the first + * scenario, the necessary data structure will be created automatically + * according to the current global model settings, i.e. this + * mode might not be threadsafe. + * However, if the provided data structure is not NULL, threadsafety + * for the model parameters #dangles, #pf_scale and #temperature is regained, since their + * values are taken from this data structure during subsequent calculations. + * + * \see get_boltzmann_factors(), update_co_pf_params() + * + * \param length Length of the current RNA sequence + * \param parameters data structure containing the precomputed Boltzmann factors + */ +void update_co_pf_params_par(int length, + pf_paramT *parameters); + +/** + * \brief Compute Boltzmann probabilities of dimerization without homodimers + * + * Given the pair probabilities and free energies (in the null model) for a + * dimer AB and the two constituent monomers A and B, compute the conditional pair + * probabilities given that a dimer AB actually forms. + * Null model pair probabilities are given as a list as produced by + * assign_plist_from_pr(), the dimer probabilities 'prAB' are modified in place. + * + * \param FAB free energy of dimer AB + * \param FEA free energy of monomer A + * \param FEB free energy of monomer B + * \param prAB pair probabilities for dimer + * \param prA pair probabilities monomer + * \param prB pair probabilities monomer + * \param Alength Length of molecule A + */ +void compute_probabilities(double FAB, + double FEA, + double FEB, + struct plist *prAB, + struct plist *prA, + struct plist *prB, + int Alength); + +/** + * \brief Given two start monomer concentrations a and b, compute the + * concentrations in thermodynamic equilibrium of all dimers and the monomers. + * + * This function takes an array 'startconc' of input concentrations with alternating + * entries for the initial concentrations of molecules A and B (terminated by + * two zeroes), then computes the resulting equilibrium concentrations + * from the free energies for the dimers. Dimer free energies should be the + * dimer-only free energies, i.e. the FcAB entries from the #cofoldF struct. + * + * \param FEAB Free energy of AB dimer (FcAB entry) + * \param FEAA Free energy of AA dimer (FcAB entry) + * \param FEBB Free energy of BB dimer (FcAB entry) + * \param FEA Free energy of monomer A + * \param FEB Free energy of monomer B + * \param startconc List of start concentrations [a0],[b0],[a1],[b1],...,[an][bn],[0],[0] + * \return ConcEnt array containing the equilibrium energies and start concentrations + */ +ConcEnt *get_concentrations(double FEAB, + double FEAA, + double FEBB, + double FEA, + double FEB, + double *startconc); + + +/** + * @} + */ + +/* +################################################# +# DEPRECATED FUNCTIONS # +################################################# +*/ + +/** + * DO NOT USE THIS FUNCTION ANYMORE + * \deprecated{ This function is deprecated and will be removed soon!} + * use \ref assign_plist_from_pr() instead! + */ +DEPRECATED(plist *get_plist( struct plist *pl, + int length, + double cut_off)); +/** + * DO NOT USE THIS FUNCTION ANYMORE + * \deprecated{ This function is deprecated and will be removed soon!} + */ +DEPRECATED(void init_co_pf_fold(int length)); + +#endif diff --git a/include/plot_layouts.h b/include/plot_layouts.h new file mode 100644 --- /dev/null +++ b/include/plot_layouts.h @@ -0,0 +1,106 @@ +/** + * \file plot_layouts.h + * + * \brief Secondary structure plot layout algorithms + * + * c Ronny Lorenz + * The ViennaRNA Package + */ +#ifndef __VIENNA_RNA_PACKAGE_PLOT_LAYOUTS_H__ +#define __VIENNA_RNA_PACKAGE_PLOT_LAYOUTS_H__ + +#include "data_structures.h" +#include "naview.h" + +#ifndef PI +#define PI 3.141592654 +#endif +#define PIHALF PI/2. + + +/** + * \brief Definition of Plot type simple + * + * This is the plot type definition for several RNA structure plotting functions telling + * them to use Simple plotting algorithm + * + * \see rna_plot_type, PS_rna_plot_a(), PS_rna_plot(), svg_rna_plot(), gmlRNA(), ssv_rna_plot(), xrna_plot() + */ +#define VRNA_PLOT_TYPE_SIMPLE 0 + +/** + * \brief Definition of Plot type Naview + * + * This is the plot type definition for several RNA structure plotting functions telling + * them to use Naview plotting algorithm + * + * \see rna_plot_type, PS_rna_plot_a(), PS_rna_plot(), svg_rna_plot(), gmlRNA(), ssv_rna_plot(), xrna_plot() + */ +#define VRNA_PLOT_TYPE_NAVIEW 1 + +/** + * \brief Definition of Plot type Circular + * + * This is the plot type definition for several RNA structure plotting functions telling + * them to produce a Circular plot + * + * \see rna_plot_type, PS_rna_plot_a(), PS_rna_plot(), svg_rna_plot(), gmlRNA(), ssv_rna_plot(), xrna_plot() + */ +#define VRNA_PLOT_TYPE_CIRCULAR 2 + + +/** + * \brief Switch for changing the secondary structure layout algorithm + * + * Current possibility are 0 for a simple radial drawing or 1 for the modified + * radial drawing taken from the \e naview program of \ref bruccoleri_88 "Bruccoleri & Heinrich (1988)". + * + * \note To provide thread safety please do not rely on this global variable in future implementations + * but pass a plot type flag directly to the function that decides which layout algorithm it may use! + * + * \see #VRNA_PLOT_TYPE_SIMPLE, #VRNA_PLOT_TYPE_NAVIEW, #VRNA_PLOT_TYPE_CIRCULAR + * + */ +extern int rna_plot_type; + +/** + * \brief Calculate nucleotide coordinates for secondary structure plot the Simple way + * + * \see make_pair_table(), rna_plot_type, simple_circplot_coordinates(), naview_xy_coordinates(), PS_rna_plot_a(), + * PS_rna_plot, svg_rna_plot() + * + * \param pair_table The pair table of the secondary structure + * \param X a pointer to an array with enough allocated space to hold the x coordinates + * \param Y a pointer to an array with enough allocated space to hold the y coordinates + * \return length of sequence on success, 0 otherwise + */ +int simple_xy_coordinates(short *pair_table, + float *X, + float *Y); + +/** + * \brief Calculate nucleotide coordinates for Circular Plot + * + * This function calculates the coordinates of nucleotides mapped in equal distancies onto a unit circle. + * + * \note In order to draw nice arcs using quadratic bezier curves that connect base pairs one may calculate + * a second tangential point \f$P^t\f$ in addition to the actual R2 coordinates. + * the simplest way to do so may be to compute a radius scaling factor \f$rs\f$ in the interval \f$[0,1]\f$ that + * weights the proportion of base pair span to the actual length of the sequence. This scaling factor + * can then be used to calculate the coordinates for \f$P^t\f$, i.e. \f$ P^{t}_x[i] = X[i] * rs\f$ + * and \f$P^{t}_y[i] = Y[i] * rs\f$. + * + * \see make_pair_table(), rna_plot_type, simple_xy_coordinates(), naview_xy_coordinates(), PS_rna_plot_a(), + * PS_rna_plot, svg_rna_plot() + * + * \param pair_table The pair table of the secondary structure + * \param x a pointer to an array with enough allocated space to hold the x coordinates + * \param y a pointer to an array with enough allocated space to hold the y coordinates + * \return length of sequence on success, 0 otherwise + */ +int simple_circplot_coordinates(short *pair_table, + float *x, + float *y); + + +#endif diff --git a/include/subopt.h b/include/subopt.h new file mode 100644 --- /dev/null +++ b/include/subopt.h @@ -0,0 +1,117 @@ +/* subopt.h */ +#ifndef __VIENNA_RNA_PACKAGE_SUBOPT_H__ +#define __VIENNA_RNA_PACKAGE_SUBOPT_H__ + +#include "data_structures.h" + +#define MAXDOS 1000 + +/** + * \addtogroup subopt_fold Enumerating Suboptimal Structures + * \ingroup folding_routines + * @{ + * \file subopt.h + * \brief RNAsubopt and density of states declarations + * + * @} + */ + +/** + * \addtogroup subopt_wuchty + * @{ + * + * @} + */ + +/** + * \brief Returns list of subopt structures or writes to fp + * + * This function produces all suboptimal secondary structures within + * 'delta' * 0.01 kcal/mol of the optimum. The results are either + * directly written to a 'fp' (if 'fp' is not NULL), or + * (fp==NULL) returned in a #SOLUTION * list terminated + * by an entry were the 'structure' pointer is NULL. + * + * \ingroup subopt_wuchty + * + * \param seq + * \param structure + * \param delta + * \param fp + * \return + */ +SOLUTION *subopt (char *seq, + char *structure, + int delta, + FILE *fp); + +/** + * \brief Returns list of subopt structures or writes to fp + * + * \ingroup subopt_wuchty + */ +SOLUTION *subopt_par( char *seq, + char *structure, + paramT *parameters, + int delta, + int is_constrained, + int is_circular, + FILE *fp); + +/** + * \brief Returns list of circular subopt structures or writes to fp + * + * This function is similar to subopt() but calculates secondary structures + * assuming the RNA sequence to be circular instead of linear + * + * \ingroup subopt_wuchty + * + * \param seq + * \param sequence + * \param delta + * \param fp + * \return + */ +SOLUTION *subopt_circ ( char *seq, + char *sequence, + int delta, + FILE *fp); + +/** + * \brief Sort output by energy + * + * \ingroup subopt_wuchty + * + */ +extern int subopt_sorted; + + +/** + * \brief printing threshold for use with logML + * + * \ingroup subopt_wuchty + * + */ +extern double print_energy; + +/** + * \addtogroup dos + * @{ + */ + +/** + * \brief The Density of States + * + * This array contains the density of states for an RNA sequences after a call to subopt_par(), + * subopt() or subopt_circ(). + * + * \pre Call one of the functions subopt_par(), subopt() or subopt_circ() prior accessing the contents + * of this array + * \see subopt_par(), subopt(), subopt_circ() + * + */ +extern int density_of_states[MAXDOS+1]; + +/** @} */ /* End of group dos */ + +#endif diff --git a/include/utils.h b/include/utils.h new file mode 100644 --- /dev/null +++ b/include/utils.h @@ -0,0 +1,615 @@ +#ifndef __VIENNA_RNA_PACKAGE_UTILS_H__ +#define __VIENNA_RNA_PACKAGE_UTILS_H__ + +/** + * \file utils.h + * \brief Various utility- and helper-functions used throughout the Vienna RNA package + */ + +/** + * Output flag of \ref get_input_line(): "An ERROR has occured, maybe EOF" + */ +#define VRNA_INPUT_ERROR 1U +/** + * Output flag of \ref get_input_line(): "the user requested quitting the program" + */ +#define VRNA_INPUT_QUIT 2U +/** + * Output flag of \ref get_input_line(): "something was read" + */ +#define VRNA_INPUT_MISC 4U + +/** Input/Output flag of \ref get_input_line():\n + * if used as input option this tells get_input_line() that the data to be read should comply + * with the FASTA format + * + * the function will return this flag if a fasta header was read + */ +#define VRNA_INPUT_FASTA_HEADER 8U + +/** Input flag for get_input_line():\n + * Tell get_input_line() that we assume to read a nucleotide sequence + * + */ +#define VRNA_INPUT_SEQUENCE 16U + +/** Input flag for get_input_line():\n + * Tell get_input_line() that we assume to read a structure constraint + * + */ +#define VRNA_INPUT_CONSTRAINT 32U + +/** + * Input switch for \ref get_input_line(): + * "do not trunkate the line by eliminating white spaces at end of line" + */ +#define VRNA_INPUT_NO_TRUNCATION 256U + +/** + * Input switch for read_record(): "do fill rest array" + */ +#define VRNA_INPUT_NO_REST 512U + +/** + * Input switch for read_record(): "never allow data to span more than one line" + */ +#define VRNA_INPUT_NO_SPAN 1024U + +/** + * Input switch for read_record(): "do not skip empty lines" + */ +#define VRNA_INPUT_NOSKIP_BLANK_LINES 2048U + +/** + * Output flag for read_record(): "read an empty line" + */ +#define VRNA_INPUT_BLANK_LINE 4096U + +/** + * Input switch for \ref get_input_line(): "do not skip comment lines" + */ +#define VRNA_INPUT_NOSKIP_COMMENTS 128U + +/** + * Output flag for read_record(): "read a comment" + */ +#define VRNA_INPUT_COMMENT 8192U + + + + +/** + * pipe sign '|' switch for structure constraints (paired with another base) + */ +#define VRNA_CONSTRAINT_PIPE 1U +/** + * dot '.' switch for structure constraints (no constraint at all) + */ +#define VRNA_CONSTRAINT_DOT 2U +/** + * 'x' switch for structure constraint (base must not pair) + */ +#define VRNA_CONSTRAINT_X 4U +/** + * angle brackets '<', '>' switch for structure constraint (paired downstream/upstream) + */ +#define VRNA_CONSTRAINT_ANG_BRACK 8U +/** + * round brackets '(',')' switch for structure constraint (base i pairs base j) + */ +#define VRNA_CONSTRAINT_RND_BRACK 16U +/** + * constraint may span over several lines + */ +#define VRNA_CONSTRAINT_MULTILINE 32U +/** + * do not print the header information line + */ +#define VRNA_CONSTRAINT_NO_HEADER 64U +/** + * placeholder for all constraining characters + */ +#define VRNA_CONSTRAINT_ALL 128U +/** + * '+' switch for structure constraint (base is involved in a gquad) + */ +#define VRNA_CONSTRAINT_G 256U + + + +/** + * Tell a function that an input is assumed to span several lines if used as input-option + * A function might also be returning this state telling that it has read data from + * multiple lines. + * + * \see extract_record_rest_structure(), read_record(), getConstraint() + * + */ +#define VRNA_OPTION_MULTILINE 32U + + +/** + * Get the minimum of two comparable values + */ +#define MIN2(A, B) ((A) < (B) ? (A) : (B)) +/** + * Get the maximum of two comparable values + */ +#define MAX2(A, B) ((A) > (B) ? (A) : (B)) +/** + * Get the minimum of three comparable values + */ +#define MIN3(A, B, C) (MIN2( (MIN2((A),(B))) ,(C))) +/** + * Get the maximum of three comparable values + */ +#define MAX3(A, B, C) (MAX2( (MAX2((A),(B))) ,(C))) + + +/** + * Stringify a macro after expansion + */ +#define XSTR(s) STR(s) +/** + * Stringify a macro argument + */ +#define STR(s) #s + +#ifndef FILENAME_MAX_LENGTH +/** + * \brief Maximum length of filenames that are generated by our programs + * + * This definition should be used throughout the complete ViennaRNA package + * wherever a static array holding filenames of output files is declared. + */ +#define FILENAME_MAX_LENGTH 80 +/** + * \brief Maximum length of id taken from fasta header for filename generation + * + * this has to be smaller than FILENAME_MAX_LENGTH since in most cases, + * some suffix will be appended to the ID + */ +#define FILENAME_ID_LENGTH 42 +#endif + + +#ifdef HAVE_CONFIG_H +#include +#ifndef HAVE_STRDUP +char *strdup(const char *s); +#endif +#endif +#ifdef WITH_DMALLOC +/* use dmalloc library to check for memory management bugs */ +#include "dmalloc.h" +#define space(S) calloc(1,(S)) +#else + +/** + * \brief Allocate space safely + * + * \param size The size of the memory to be allocated in bytes + * \return A pointer to the allocated memory + */ +/*@only@*/ /*@notnull@*/ +void *space(unsigned size) /*@ensures MaxSet(result) == (size-1);@*/; + +/** + * \brief Reallocate space safely + * + * \param p A pointer to the memory region to be reallocated + * \param size The size of the memory to be allocated in bytes + * \return A pointer to the newly allocated memory + */ +/*@only@*/ /*@notnull@*/ +void *xrealloc(/*@null@*/ /*@only@*/ /*@out@*/ /*@returned@*/ void *p, + unsigned size) /*@modifies *p @*/ /*@ensures MaxSet(result) == (size-1) @*/; +#endif + +/** + * \brief Die with an error message + * + * \see warn_user() + * \param message The error message to be printed before exiting with 'FAILURE' + */ +/*@exits@*/ +void nrerror(const char message[]); + +/** + * \brief Print a warning message + * + * Print a warning message to \e stderr + * + * \param message The warning message + */ +void warn_user(const char message[]); + +/** + * \brief Make random number seeds + */ +void init_rand(void); + +/** + * \brief Current 48 bit random number + * + * This variable is used by urn(). These should be set to some + * random number seeds before the first call to urn(). + * + * \see urn() + */ +extern unsigned short xsubi[3]; + +/** + * \brief get a random number from [0..1] + * + * \note Usually implemented by calling \e erand48(). + * \return A random number in range [0..1] + */ +double urn(void); + +/** + * \brief Generates a pseudo random integer in a specified range + * + * \param from The first number in range + * \param to The last number in range + * \return A pseudo random number in range [from, to] + */ +int int_urn(int from, int to); + +void filecopy(FILE *from, FILE *to); /* inefficient `cp' */ + +/** + * \brief Get a timestamp + * + * Returns a string containing the current date in the format + * \verbatim Fri Mar 19 21:10:57 1993\endverbatim + * + * \return A string containing the timestamp + */ +/*@observer@*/ +char *time_stamp(void); + +/** + * \brief Create a random string using characters from a specified symbol set + * + * \param l The length of the sequence + * \param symbols The symbol set + * \return A random string of length 'l' containing characters from the symbolset + */ +/*@only@*/ /*@notnull@*/ +char *random_string(int l, const char symbols[]); + +/** + * \brief Calculate hamming distance between two sequences + * + * Calculate the number of positions in which + * \param s1 The first sequence + * \param s2 The second sequence + * \return The hamming distance between s1 and s2 + */ +int hamming(const char *s1, const char *s2); + +/** + * \brief Calculate hamming distance between two sequences up to a specified length + * + * This function is similar to hamming() but instead of comparing both sequences + * up to their actual length only the first 'n' characters are taken into account + * \param s1 The first sequence + * \param s2 The second sequence + * \return The hamming distance between s1 and s2 + */ +int hamming_bound(const char *s1, const char *s2, int n); + +/** + * \brief Read a line of arbitrary length from a stream + * + * Returns a pointer to the resulting string. The necessary memory is + * allocated and should be released using \e free() when the string is + * no longer needed. + * + * \param fp A file pointer to the stream where the function should read from + * \return A pointer to the resulting string + */ +/*@only@*/ /*@null@*/ +char *get_line(FILE *fp); + +int skip_comment_lines(char **line); + +/** + * Retrieve a line from 'stdin' savely while skipping comment characters and + * other features + * This function returns the type of input it has read if recognized. + * An option argument allows to switch between different reading modes.\n + * Currently available options are:\n + * #VRNA_INPUT_NOPRINT_COMMENTS, #VRNA_INPUT_NOSKIP_COMMENTS, #VRNA_INPUT_NOELIM_WS_SUFFIX + * + * pass a collection of options as one value like this: + * \verbatim get_input_line(string, option_1 | option_2 | option_n) \endverbatim + * + * If the function recognizes the type of input, it will report it in the return + * value. It also reports if a user defined 'quit' command (@-sign on 'stdin') + * was given. Possible return values are:\n + * #VRNA_INPUT_FASTA_HEADER, #VRNA_INPUT_ERROR, #VRNA_INPUT_MISC, #VRNA_INPUT_QUIT + * + * \param string A pointer to the character array that contains the line read + * \param options A collection of options for switching the functions behavior + * \return A flag with information about what has been read + */ +unsigned int get_input_line(char **string, + unsigned int options); + +unsigned int get_multi_input_line(char **string, + unsigned int options); + +/** + * \brief Get a data record from stdin + * + * This function may be used to obtain complete datasets from stdin. A dataset is always + * defined to contain at least a sequence. If data on stdin starts with a fasta header, + * i.e. a line like + * \verbatim >some header info \endverbatim + * then read_record() will assume that the sequence that follows the header may span + * over several lines. To disable this behavior and to assign a single line to the argument + * 'sequence' one can pass VRNA_INPUT_NO_SPAN in the 'options' argument. + * If no fasta header is read in the beginning of a data block, a sequence must not span over + * multiple lines!\n + * Unless the options #VRNA_INPUT_NOSKIP_COMMENTS or #VRNA_INPUT_NOSKIP_BLANK_LINES are passed, + * a sequence may be interrupted by lines starting with a comment character or empty lines.\n + * A sequence is regarded as completely read if it was either assumed to not span over multiple + * lines, a secondary structure or structure constraint follows the sequence on the next line + * or a new header marks the beginning of a new sequence...\n + * All lines following the sequence (this includes comments) and not initiating a new dataset are + * available through the line-array 'rest'. Here one can usually find the structure constraint or + * other information belonging to the current dataset. Filling of 'rest' may be prevented by + * passing #VRNA_INPUT_NO_REST to the options argument.\n + * + * \note This function will exit any program with an error message if no sequence could be read! + * + * The main purpose of this function is to be able to easily parse blocks of data from stdin + * in the header of a loop where all calculations for the appropriate data is done inside the + * loop. The loop may be then left on certain return values, e.g.: + * \verbatim +char *id, *seq, **rest; +int i; +while(!(read_record(&id, &seq, &rest, 0) & (VRNA_INPUT_ERROR | VRNA_INPUT_QUIT))){ + if(id) printf("%s\n", id); + printf("%s\n", seq); + if(rest) + for(i=0;rest[i];i++) + printf("%s\n", rest[i]); +} \endverbatim + * + * In the example above, the while loop will be terminated when read_record() returns either an + * error or a user initiated quit request.\n + * As long as data is read from stdin, the id is printed if it is available for the current block + * of data. The sequence will be printed in any case and if some more lines belong to the current + * block of data each line will be printed as well. + * + * \note Do not forget to free the memory occupied by header, sequence and rest! + * + * \param header A pointer which will be set such that it points to the header of the record + * \param sequence A pointer which will be set such that it points to the sequence of the record + * \param rest A pointer which will be set such that it points to an array of lines which also belong to the record + * \param options Some options which may be passed to alter the behavior of the function, use 0 for no options + * \return A flag with information about what the function actually did read + */ +unsigned int read_record( char **header, + char **sequence, + char ***rest, + unsigned int options); + + +/* \brief Extract a dot-bracket structure string from (multiline)character array + * + * This function extracts a dot-bracket structure string from the 'rest' array as + * returned by read_record() and returns it. All occurences of comments within the + * 'lines' array will be skipped as long as they do not break the structure string. + * If no structure could be read, this function returns NULL. + * + * \see read_record() + * + * \param lines The (multiline) character array to be parsed + * \param length The assumed length of the dot-bracket string (passing a value < 1 results in no length limit) + * \param option Some options which may be passed to alter the behavior of the function, use 0 for no options + * \return The dot-bracket string read from lines or NULL + */ +char *extract_record_rest_structure(const char **lines, + unsigned int length, + unsigned int option); + +/** + * \brief Pack secondary secondary structure, 5:1 compression using base 3 encoding + * + * Returns a binary string encoding of the secondary structure using + * a 5:1 compression scheme. The string is NULL terminated and can + * therefore be used with standard string functions such as strcmp(). + * Useful for programs that need to keep many structures in memory. + * + * \param struc The secondary structure in dot-bracket notation + * \return The binary encoded structure + */ +char *pack_structure(const char *struc); + +/** + * \brief Unpack secondary structure previously packed with pack_structure() + * + * Translate a compressed binary string produced by pack_structure() back into + * the familiar dot-bracket notation. + * + * \param packed The binary encoded packed secondary structure + * \return The unpacked secondary structure in dot-bracket notation + */ +char *unpack_structure(const char *packed); + +/** + * \brief Create a pair table of a secondary structure + * + * Returns a newly allocated table, such that table[i]=j if (i.j) pair + * or 0 if i is unpaired, table[0] contains the length of the structure. + * + * \param structure The secondary structure in dot-bracket notation + * \return A pointer to the created pair_table + */ +short *make_pair_table(const char *structure); + +short *make_pair_table_pk(const char *structure); + +/** + * \brief Get an exact copy of a pair table + * + * \param pt The pair table to be copied + * \return A pointer to the copy of 'pt' + */ +short *copy_pair_table(const short *pt); + +/** +***Pair table for snoop align +*** +*** +**/ +short *alimake_pair_table(const char *structure); + +/** +*** returns a newly allocated table, such that: table[i]=j if (i.j) pair or +*** 0 if i is unpaired, table[0] contains the length of the structure. +*** The special pseudoknotted H/ACA-mRNA structure is taken into account. +**/ +short *make_pair_table_snoop(const char *structure); + +/** + * \brief Compute the "base pair" distance between two secondary structures s1 and s2. + * + * The sequences should have the same length. + * dist = number of base pairs in one structure but not in the other + * same as edit distance with open-pair close-pair as move-set + * + * \param str1 First structure in dot-bracket notation + * \param str2 Second structure in dot-bracket notation + * \return The base pair distance between str1 and str2 + */ + +int *make_loop_index_pt(short *pt); + + +int bp_distance(const char *str1, + const char *str2); + +/** + * \brief Print a line to \e stdout that asks for an input sequence + * + * There will also be a ruler (scale line) printed that helps orientation of the sequence positions + */ +void print_tty_input_seq(void); + +/** + * \brief Print a line with a user defined string and a ruler to stdout. + * + * (usually this is used to ask for user input) + * There will also be a ruler (scale line) printed that helps orientation of the sequence positions + * + * \param s A user defined string that will be printed to stdout + */ +void print_tty_input_seq_str(const char *s); + +/** + * \brief Print structure constraint characters to stdout + * (full constraint support) + * + */ +void print_tty_constraint_full(void); + +/** + * \brief Print structure constraint characters to stdout. + * (constraint support is specified by option parameter) + * + * Currently available options are:\n + * #VRNA_CONSTRAINT_PIPE (paired with another base)\n + * #VRNA_CONSTRAINT_DOT (no constraint at all)\n + * #VRNA_CONSTRAINT_X (base must not pair)\n + * #VRNA_CONSTRAINT_ANG_BRACK (paired downstream/upstream)\n + * #VRNA_CONSTRAINT_RND_BRACK (base i pairs base j)\n + * + * pass a collection of options as one value like this: + * \verbatim print_tty_constraint(option_1 | option_2 | option_n) \endverbatim + * + * \param option Option switch that tells which constraint help will be printed + */ +void print_tty_constraint(unsigned int option); + +/** + * \brief Convert a DNA input sequence to RNA alphabet + * + * This function substitudes T and t with U and u, respectively + * + * \param sequence The sequence to be converted + */ +void str_DNA2RNA(char *sequence); + +/** + * \brief Convert an input sequence to uppercase + * + * \param sequence The sequence to be converted + */ +void str_uppercase(char *sequence); + +/** + * \brief Get an index mapper array (iindx) for accessing the energy matrices, e.g. in partition function related functions. + * + * Access of a position "(i,j)" is then accomplished by using \verbatim (i,j) ~ iindx[i]-j \endverbatim + * This function is necessary as most of the two-dimensional energy matrices are actually one-dimensional arrays throughout + * the ViennaRNAPackage + * + * Consult the implemented code to find out about the mapping formula ;) + * + * \see get_indx() + * \param length The length of the RNA sequence + * \return The mapper array + */ +int *get_iindx(unsigned int length); + +/** + * \brief Get an index mapper array (indx) for accessing the energy matrices, e.g. in MFE related functions. + * + * Access of a position "(i,j)" is then accomplished by using \verbatim (i,j) ~ indx[j]+i \endverbatim + * This function is necessary as most of the two-dimensional energy matrices are actually one-dimensional arrays throughout + * the ViennaRNAPackage + * + * Consult the implemented code to find out about the mapping formula ;) + * + * \see get_iindx() + * \param length The length of the RNA sequence + * \return The mapper array + * + */ +int *get_indx(unsigned int length); + +void getConstraint( char **cstruc, + const char **lines, + unsigned int option); + +/** + * \brief Insert constraining pair types according to constraint structure string + * + * \see get_indx(), get_iindx() + * + * \param constraint The structure constraint string + * \param length The actual length of the sequence (constraint may be shorter) + * \param ptype A pointer to the basepair type array + * \param min_loop_size The minimal loop size (usually \ref TURN ) + * \param idx_type Define the access type for base pair type array (0 = indx, 1 = iindx) + */ +void constrain_ptypes(const char *constraint, + unsigned int length, + char *ptype, + int *BP, + int min_loop_size, + unsigned int idx_type); + +unsigned int *make_referenceBP_array(short *reference_pt, + unsigned int turn); + +unsigned int *compute_BPdifferences( short *pt1, + short *pt2, + unsigned int turn); + +#endif