diff --git a/Biobase/Vienna.hs b/Biobase/Vienna.hs --- a/Biobase/Vienna.hs +++ b/Biobase/Vienna.hs @@ -1,89 +1,56 @@ -{-# LANGUAGE NoMonomorphismRestriction #-} --- | Turner energy data as used in the ViennaRNA package. +-- | The Vienna 2004 model is a mirror of the Turner data structure. The +-- difference is that The ViennaRNA package uses an explicit annotation for RNA +-- basepairs. -- --- TODO should use energy type for tables, not int! +-- Furthermore, all energies are stored in parts of 1/100, using Ints instead +-- of Doubles. module Biobase.Vienna where -import Data.Map (Map,empty) +import Data.ByteString (ByteString) +import Data.Map (Map) -import Data.Ix.Tuple -import Data.PrimitiveArray.Ix import Data.PrimitiveArray -import Biobase.Types.Partition -import Biobase.Types.Energy - -import Biobase.RNA -import Biobase.Turner.Tables -import Biobase.Constants - - - --- Type for Vienna Tables - --- type ViennaEnergySet = (Temperature, ViennaTables, ViennaTables) - -type ViennaIntTables = Turner2004 ViennaPair Nucleotide Int -type ViennaEnergyTables = Turner2004 ViennaPair Nucleotide Energy -type ViennaPartitionTables = Turner2004 ViennaPair Nucleotide Partition - -type Temperature = Double - - - --- | An empty Turner2004 set, with Vienna-style keys for tables. Unused fields --- are commented out. Activate them in BiobaseTurner before doing the same --- here! - -emptyTables :: ViennaIntTables -emptyTables = Turner2004 - --stack - { stack = emptyIV - --dangle - , dangle3 = emptyIV - , dangle5 = emptyIV - --hairpin - , hairpinL = emptyV - , hairpinMM = emptyIV - , hairpinLookup = empty - --eInf - --eInf - --eInf - --eInf - --bulge - , bulgeL = emptyV - --eInf - --internal - , iloop1x1 = emptyIV - , iloop1x2 = emptyIV - , iloop2x2 = emptyIV - , iloopMM = emptyIV - , iloop2x3MM = emptyIV - , iloop1xnMM = emptyIV - , iloopL = emptyV - --multibranch - , multiMM = emptyIV - , ninio = eInf - , maxNinio = eInf - , multiOffset = eInf - , multiNuc = eInf - , multiHelix = eInf - --eInf - --eInf - --exterior - , extMM = emptyIV - --coaxial stacking - --emptyIV - --emptyIV - --emptyIV - --scalar values - , largeLoop = fInf -- large loop is always double - , termAU = eInf - , intermolecularInit = eInf - } +import Biobase.Primary +import Biobase.Secondary.Vienna -emptyIV = fromAssocs minBound maxBound eInf [] +data Vienna2004 = Vienna2004 + { stack :: PrimArray (ViennaPair,ViennaPair) Int + , dangle3 :: PrimArray PN Int + , dangle5 :: PrimArray PN Int + , hairpinL :: PrimArray Int Int + , hairpinMM :: PrimArray PNN Int + , hairpinLookup :: Map [Nuc] Int + , hairpinGGG :: Int + , hairpinCslope :: Int + , hairpinCintercept :: Int + , hairpinC3 :: Int + , bulgeL :: PrimArray Int Int + , bulgeSingleC :: Int + , iloop1x1 :: PrimArray (ViennaPair,ViennaPair,(Nuc,Nuc)) Int + , iloop2x1 :: PrimArray (ViennaPair,ViennaPair,(Nuc,Nuc,Nuc)) Int + , iloop2x2 :: PrimArray (ViennaPair,ViennaPair,(Nuc,Nuc,Nuc,Nuc)) Int + , iloopMM :: PrimArray PNN Int + , iloop2x3MM :: PrimArray PNN Int + , iloop1xnMM :: PrimArray PNN Int + , iloopL :: PrimArray Int Int + , multiMM :: PrimArray PNN Int + , ninio :: Int + , maxNinio :: Int + , multiOffset :: Int + , multiNuc :: Int + , multiHelix :: Int + , multiAsym :: Int + , multiStrain :: Int + , extMM :: PrimArray PNN Int + , coaxial :: PrimArray (ViennaPair,ViennaPair) Int -- no intervening unpaired nucleotides + , coaxStack :: PrimArray PNN Int + , tStackCoax :: PrimArray PNN Int + , largeLoop :: Int + , termAU :: Int + , intermolecularInit :: Int + } -- deriving (Read,Show) --- TODO should be an empty a -emptyV = fromAssocs 0 30 eInf [] +type PNN = (ViennaPair,Nuc,Nuc) +type PN = (ViennaPair,Nuc) diff --git a/Biobase/Vienna/Default.hs b/Biobase/Vienna/Default.hs deleted file mode 100644 --- a/Biobase/Vienna/Default.hs +++ /dev/null @@ -1,27 +0,0 @@ - -{-# LANGUAGE TemplateHaskell #-} - --- | Embedding of a default set of parameters. These are encoded in Vienna style and --- use the Turner2004 set of parameters. - -module Biobase.Vienna.Default - ( turner2004GH - ) where - -import Data.FileEmbed -import qualified Data.ByteString.Char8 as B - -import Biobase.Vienna.Import.ViennaPar -import Biobase.Turner.Tables -import Biobase.Vienna -import Biobase.Types.Energy - - - -defaultPars :: B.ByteString -defaultPars = $(embedFile "parfiles/Turner2004GH.par") - --- Turner entropy and enthalpy tables. - -turner2004GH = (dmap Energy ta,dmap Energy tb) where - (ta,tb) = importPar $ B.unpack defaultPars diff --git a/Biobase/Vienna/Export.hs b/Biobase/Vienna/Export.hs new file mode 100644 --- /dev/null +++ b/Biobase/Vienna/Export.hs @@ -0,0 +1,137 @@ +{-# LANGUAGE NoMonomorphismRestriction #-} + +module Biobase.Vienna.Export where + +import Control.Arrow +import Data.List (intersperse) +import Data.List.Split +import qualified Data.Map as M +import Text.Printf + +import Biobase.Primary +import Biobase.Secondary.Vienna +import Data.PrimitiveArray +import Data.PrimitiveArray.Ix + +import Biobase.Vienna + + + +-- * Export as a ViennaRNA 2004 ".par" file + +asPar :: Vienna2004 -> Vienna2004 -> String +asPar trnr trnrH = hdr ++ blocks ++ mlps ++ ninios ++ misc ++ triloops ++ tetra ++ hexa ++ "\n#END" where + hdr = "## RNAfold parameter file v2.0\n\n" + mlps = printf "# ML_params\n%7d %7d %7d %7d %7d %7d\n\n" + (multiNuc trnr) (multiNuc trnrH) + (multiOffset trnr) (multiOffset trnrH) + (multiHelix trnr) (multiHelix trnrH) + ninios = printf "# NINIO\n%7d %7d %7d\n\n" + (ninio trnr) (ninio trnrH) (maxNinio trnr) + misc = printf "# Misc\n %7d %7d %7d %7d\n\n" + (intermolecularInit trnr) (intermolecularInit trnrH) (termAU trnr) (termAU trnrH) + triloops = "# Triloops\n" ++ printHairpinAssocs 5 trnr trnrH ++ "\n" + tetra = "# Tetraloops\n" ++ printHairpinAssocs 6 trnr trnrH ++ "\n" + hexa = "# Hexaloops\n" ++ printHairpinAssocs 8 trnr trnrH ++ "\n" + blocks = concat $ zipWith (++) + -- entropy terms + [ printBlock "stack" 7 pp2lkey $ stack trnr + , printBlock "mismatch_hairpin" 5 pbb2lkey $ hairpinMM trnr + , printBlock "mismatch_interior" 5 pbb2lkey $ iloopMM trnr + , printBlock "mismatch_interior_1n" 5 pbb2lkey $ iloop1xnMM trnr + , printBlock "mismatch_interior_23" 5 pbb2lkey $ iloop2x3MM trnr + , printBlock "mismatch_multi" 5 pbb2lkey $ multiMM trnr + , printBlock "mismatch_exterior" 5 pbb2lkey $ extMM trnr + , printBlock "dangle5" 5 pb2lkey $ dangle5 trnr + , printBlock "dangle3" 5 pb2lkey $ dangle3 trnr + , printBlock "int11" 5 ppbb2lkey $ iloop1x1 trnr + , printBlock "int21" 5 ppbbb2lkey $ iloop2x1 trnr + , printBlock22 "int22" 4 ppbbbb2lkey $ iloop2x2 trnr + , printLinear "hairpin" 10 $ hairpinL trnr + , printLinear "bulge" 10 $ bulgeL trnr + , printLinear "interior" 10 $ iloopL trnr + ] + -- enthalpy terms + [ printBlockH "stack" 7 pp2lkey $ stack trnrH + , printBlockH "mismatch_hairpin" 5 pbb2lkey $ hairpinMM trnrH + , printBlockH "mismatch_interior" 5 pbb2lkey $ iloopMM trnrH + , printBlockH "mismatch_interior_1n" 5 pbb2lkey $ iloop1xnMM trnrH + , printBlockH "mismatch_interior_23" 5 pbb2lkey $ iloop2x3MM trnrH + , printBlockH "mismatch_multi" 5 pbb2lkey $ multiMM trnrH + , printBlockH "mismatch_exterior" 5 pbb2lkey $ extMM trnrH + , printBlockH "dangle5" 5 pb2lkey $ dangle5 trnrH + , printBlockH "dangle3" 5 pb2lkey $ dangle3 trnrH + , printBlockH "int11" 5 ppbb2lkey $ iloop1x1 trnrH + , printBlockH "int21" 5 ppbbb2lkey $ iloop2x1 trnrH + , printBlock22H "int22" 4 ppbbbb2lkey $ iloop2x2 trnrH + , printLinearH "hairpin" 10 $ hairpinL trnrH + , printLinearH "bulge" 10 $ bulgeL trnrH + , printLinearH "interior" 10 $ iloopL trnrH + ] + + + +-- * Helper functions + +-- | Show the key of the line, minus the changing last key + +showKey :: [(LKey,Int)] -> String +showKey xs = + " /* " ++ + (concat $ intersperse "," $ init $ (map show ps) ++ (map show ns)) ++ + " */" + where + (ps,ns) = fst $ head xs + +-- | Transform from tuple-based keys to a pair of list-based keys. + +type LKey = ([ViennaPair],[Nuc]) + +pb2lkey (p1,b1) = ([p1],[b1]) +pbb2lkey (p1,b1,b2) = ([p1],[b1,b2]) +pp2lkey (k1,k2) = ([k1,k2],[]) +ppbb2lkey (p1,p2,(b1,b2)) = ([p1,p2],[b1,b2]) +ppbbb2lkey (p1,p2,(b1,b2,b3)) = ([p1,p2],[b1,b2,b3]) +ppbbbb2lkey (p1,p2,(b1,b2,b3,b4)) = ([p1,p2],[b1,b2,b3,b4]) + +-- | Print a block. + +printBlock = printBlockG noNP where + noNP ((ps,ns),v) = not $ any (==vpNP) ps || any (==nIMI) ns + +printBlockH s = printBlock (s ++ "_enthalpies") + +printBlock22 = printBlockG noNSNPE where + noNSNPE ((ps,ns),v) = not $ any (==vpNP) ps || any (==vpNS) ps || any (==nN) ns || any (==nIMI) ns + +printBlock22H s = printBlock22 (s ++ "_enthalpies") + +printBlockG fltr s k tolkey xs' = + let + xs = filter fltr $ map (first tolkey) $ assocs xs' + in + printf "# %s\n" s ++ + (concatMap printLine $ splitEvery k xs) ++ + "\n" + +printLine xs = + concatMap printVal xs ++ " " ++ showKey xs ++ + printf "\n" + +printVal (k,v) + | v > 10000 = printf " INF" + | otherwise = printf "%6d" v + +-- | A linear block is more boring + +printLinear s k xs' = let xs = assocs xs' in + printf "# %s\n" s ++ + (concatMap (\ys -> concatMap printVal ys ++ "\n") $ splitEvery k xs) ++ + "\n" + +printHairpinAssocs l trnr trnrH = res where + res = concat $ zipWith (\(k,v) vH -> printf "%s %7d %7d\n" (concatMap show k) v vH) xs ys + xs = filter ((==l).length.fst) $ M.assocs $ hairpinLookup trnr + ys = map snd $ filter ((==l).length.fst) $ M.assocs $ hairpinLookup trnrH + +printLinearH s = printLinear (s ++ "_enthalpies") diff --git a/Biobase/Vienna/Export/ViennaC.hs b/Biobase/Vienna/Export/ViennaC.hs deleted file mode 100644 --- a/Biobase/Vienna/Export/ViennaC.hs +++ /dev/null @@ -1,264 +0,0 @@ -{-# LANGUAGE ScopedTypeVariables #-} -{-# LANGUAGE TemplateHaskell #-} - --- | Exports the Vienna energy tables as a number of C files (one .c file, a --- number .h files). For this reason, files are written into a target --- directory! - -module Biobase.Vienna.Export.ViennaC - ( export - ) where - -import Prelude hiding (pi) -import Text.Printf -import System.Directory -import Data.List.Split -import Data.List -import qualified Data.Map as M -import Data.FileEmbed -import qualified Data.ByteString.Char8 as B - -import Biobase.Turner.Tables -import Biobase.Vienna -import Data.PrimitiveArray -import Biobase.RNA - -import Biobase.Vienna.Default - -(g,h) = turner2004GH - - - -type Directory = FilePath - --- | Export the files required for default values in the ViennaRNA 2.0 C --- package. - -export :: ViennaIntTables -> ViennaIntTables -> Directory -> IO () -export trnrG trnrH target = mapM_ (\f -> f trnrG trnrH target) [exportC, export11, export21, export22] - - - --- | Export the main C file - -exportC :: ViennaIntTables -> ViennaIntTables -> Directory -> IO () -exportC trnrG trnrH target = writeFile (target ++ "/energy_par.c") out where - out = unlines [ B.unpack $(embedFile "templates/cheader") , xs, stck, lps, mms, dngls, tris, tets, hexs,includes] - xs = unlines - [ pd "lxc37" $ largeLoop trnrG - , pi "ML_intern37" $ multiHelix trnrG - , pi "ML_interndH" $ multiHelix trnrH - , pi "ML_closing37" $ multiOffset trnrG - , pi "ML_closingdH" $ multiOffset trnrH - , pi "ML_BASE37" $ multiNuc trnrG - , pi "ML_BASEdH" $ multiNuc trnrH - , pi "MAX_NINIO" $ maxNinio trnrG - , pi "ninio37" $ ninio trnrG - , pi "niniodH" $ ninio trnrH - , pi "TerminalAU37" $ termAU trnrG - , pi "TerminalAUdH" $ termAU trnrH - , pi "DuplexInit37" $ intermolecularInit trnrG - , pi "DuplexInitdH" $ intermolecularInit trnrH - , pi "TripleC37" 100 - , pi "TripleCdH" 1860 - , pi "MultipleCA37" 30 - , pi "MultipleCAdH" 340 - , pi "MultipleCB37" 160 - , pi "MultipleCBdH" 760 - ] - stck = unlines - [ "PUBLIC int stack37[NBPAIRS+1][NBPAIRS+1] =" - , (block2 8 . toList $ stack trnrG) - , "PUBLIC int stackdH[NBPAIRS+1][NBPAIRS+1] =" - , (block2 8 . toList $ stack trnrH) - ] - lps = unlines - [ "PUBLIC int hairpin37[31] = {" ++ (concat . intersperse "," . map printNum . toList $ hairpinL trnrG) ++ "};" - , "PUBLIC int hairpindH[31] = {" ++ (concat . intersperse "," . map printNum . toList $ hairpinL trnrH) ++ "};" - , "PUBLIC int bulge37[31] = {" ++ (concat . intersperse "," . map printNum . toList $ bulgeL trnrG) ++ "};" - , "PUBLIC int bulgedH[31] = {" ++ (concat . intersperse "," . map printNum . toList $ bulgeL trnrH) ++ "};" - , "PUBLIC int internal_loop37[31] = {" ++ (concat . intersperse "," . map printNum . toList $ iloopL trnrG) ++ "};" - , "PUBLIC int internal_loopdH[31] = {" ++ (concat . intersperse "," . map printNum . toList $ iloopL trnrH) ++ "};" - ] - mms = unlines - [ writeMM "I" iloopMM trnrG trnrH - , writeMM "H" hairpinMM trnrG trnrH - , writeMM "M" multiMM trnrG trnrH - , writeMM "1nI" iloop1xnMM trnrG trnrH - , writeMM "23I" iloop2x3MM trnrG trnrH - , writeMM "Ext" extMM trnrG trnrH - ] - dngls = unlines - [ "PUBLIC int dangle3_37[NBPAIRS+1][5] =" - , block2 5 . toList $ dangle3 trnrG - , "PUBLIC int dangle3_dH[NBPAIRS+1][5] =" - , block2 5 . toList $ dangle3 trnrH - , "PUBLIC int dangle5_37[NBPAIRS+1][5] =" - , block2 5 . toList $ dangle5 trnrG - , "PUBLIC int dangle5_dH[NBPAIRS+1][5] =" - , block2 5 . toList $ dangle5 trnrH - ] - t3 = getLookup 3 trnrG trnrH - t4 = getLookup 4 trnrG trnrH - t6 = getLookup 6 trnrG trnrH - tris = writeTabbed 3 "Triloop" t3 - tets = writeTabbed 4 "Tetraloop" t4 - hexs = writeTabbed 6 "Hexaloop" t6 - - includes = unlines $ map ((++ "\"") . ("#include \""++)) - [ "intl11.h" - , "intl11dH.h" - , "intl21.h" - , "intl21dH.h" - , "intl22.h" - , "intl22dH.h" - ] - - - --- | Export iloops 1x1 - -export11 :: ViennaIntTables -> ViennaIntTables -> Directory -> IO () -export11 trnrG trnrH target = writeFile (target ++ "/intl11.h") outG >> writeFile (target ++ "/intl11dH.h") outH where - outG = unlines - [ "PUBLIC int int11_37[NBPAIRS+1][NBPAIRS+1][5][5] =" - , (block4 8 5 5 . toList $ iloop1x1 trnrG) - ] - outH = unlines - [ "PUBLIC int int11_dH[NBPAIRS+1][NBPAIRS+1][5][5] =" - , (block4 8 5 5 . toList $ iloop1x1 trnrH) - ] - - - --- | Export iloops 2x1 - -export21 :: ViennaIntTables -> ViennaIntTables -> Directory -> IO () -export21 trnrG trnrH target = writeFile (target ++ "/intl21.h") outG >> writeFile (target ++ "/intl21dH.h") outH where - outG = unlines - [ "PUBLIC int int21_37[NBPAIRS+1][NBPAIRS+1][5][5][5] =" - , (block5 8 5 5 5 . toList $ iloop1x2 trnrG) - ] - outH = unlines - [ "PUBLIC int int21_dH[NBPAIRS+1][NBPAIRS+1][5][5][5] =" - , (block5 8 5 5 5 . toList $ iloop1x2 trnrH) - ] - - - --- | Export iloops 2x2 - -export22 :: ViennaIntTables -> ViennaIntTables -> Directory -> IO () -export22 trnrG trnrH target = writeFile (target ++ "/intl22.h") outG >> writeFile (target ++ "/intl22dH.h") outH where - outG = unlines - [ "PUBLIC int int22_37[NBPAIRS+1][NBPAIRS+1][5][5][5][5] =" - , (block6 8 5 5 5 5 . toList $ iloop2x2 trnrG) - ] - outH = unlines - [ "PUBLIC int int22_dH[NBPAIRS+1][NBPAIRS+1][5][5][5][5] =" - , (block6 8 5 5 5 5 . toList $ iloop2x2 trnrH) - ] - - - --- * Helper functions - -writeTabbed (ksize :: Int) key (ns,gs,hs) = unlines - [ printf "PUBLIC char %ss[%d] =" key ((ksize+3)*40+1) - , ns - , ";" - ] ++ printf "PUBLIC int %s37[40] = " key ++ gs ++ ";\n" - ++ printf "PUBLIC int %sdH[40] = " key ++ hs ++ ";\n" - -getLookup k trnrG trnrH = (nsF,gs,hs) where - nsF = concat $ intersperse "\n" $ map ((++ " \"") . (" \"" ++) . map nucleotideToChar) ns - ns = filter ((==(k+2)) . length) . M.keys $ hairpinLookup trnrG - gs = lkup trnrG - hs = lkup trnrH - lkup tbl = ("{"++) . (++"}") . concat . intersperse "," $ map (printNum . (hairpinLookup tbl M.!)) ns - -writeMM typ fun trnrG trnrH = unlines - [ printf "PUBLIC int mismatch%s37[NBPAIRS+1][5][5] =" typ - , block3 5 5 . toList $ fun trnrG - , printf "PUBLIC int mismatch%sdH[NBPAIRS+1][5][5] =" typ - , block3 5 5 . toList $ fun trnrH - ] - -block2 s2 xs - = (++ "};") - . ("{" ++) - . concat - . intersperse "\n," - . map ((++ "}") . ("{" ++) . concat . intersperse ",") - . splitEvery s2 - $ map printNum xs - -block3 s2 s3 xs - = (++ "};") - . ("{" ++) - . concat - . intersperse "\n," - . map ((++ "}") . ("{" ++) . concat . intersperse ",") - . splitEvery s2 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s3 - $ map printNum xs - -block4 s2 s3 s4 xs - = (++ "};") - . ("{" ++) - . concat - . intersperse "\n," - . map ((++ "}") . ("{" ++) . concat . intersperse ",") - . splitEvery s2 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s3 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s4 - $ map printNum xs - -block5 s2 s3 s4 s5 xs - = (++ "};") - . ("{" ++) - . concat - . intersperse "\n," - . map ((++ "}") . ("{" ++) . concat . intersperse ",") - . splitEvery s2 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s3 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s4 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s5 - $ map printNum xs - -block6 s2 s3 s4 s5 s6 xs - = (++ "};") - . ("{" ++) - . concat - . intersperse "\n," - . map ((++ "}") . ("{" ++) . concat . intersperse ",") - . splitEvery s2 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s3 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s4 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s5 - . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",") - . splitEvery s6 - $ map printNum xs - - -pd :: String -> Double -> String -pd k v = printf "PUBLIC double %s=%f;" k v - -pi :: String -> Int -> String -pi k v = printf "PUBLIC int %s=%d;" k v - -printNum :: Int -> String -printNum n - | n >= maxN = " INF" - | otherwise = printf "%6d" n - where - maxN = 10000 diff --git a/Biobase/Vienna/Export/ViennaPar.hs b/Biobase/Vienna/Export/ViennaPar.hs deleted file mode 100644 --- a/Biobase/Vienna/Export/ViennaPar.hs +++ /dev/null @@ -1,139 +0,0 @@ - -{-# LANGUAGE NoMonomorphismRestriction #-} - -module Biobase.Vienna.Export.ViennaPar - ( export - ) where - -import Data.Tuple.Select -import Data.List.Split -import Text.Printf -import Control.Arrow -import Data.List (intersperse) -import qualified Data.Map as M - -import Data.PrimitiveArray -import Biobase.Turner.Tables -import Biobase.RNA -import Biobase.Constants - -import Biobase.Vienna - - - -export :: ViennaIntTables -> ViennaIntTables -> String -export trnr trnrH = hdr ++ blocks ++ mlps ++ ninios ++ misc ++ triloops ++ tetra ++ hexa ++ "\n#END" where - hdr = "## RNAfold parameter file v2.0\n\n" - mlps = printf "# ML_params\n%7d %7d %7d %7d %7d %7d\n\n" - (multiNuc trnr) (multiNuc trnrH) - (multiOffset trnr) (multiOffset trnrH) - (multiHelix trnr) (multiHelix trnrH) - ninios = printf "# NINIO\n%7d %7d %7d\n\n" - (ninio trnr) (ninio trnrH) (maxNinio trnr) - misc = printf "# Misc\n %7d %7d %7d %7d\n\n" - (intermolecularInit trnr) (intermolecularInit trnrH) (termAU trnr) (termAU trnrH) - triloops = "# Triloops\n" ++ printHairpinAssocs 5 trnr trnrH ++ "\n" - tetra = "# Tetraloops\n" ++ printHairpinAssocs 6 trnr trnrH ++ "\n" - hexa = "# Hexaloops\n" ++ printHairpinAssocs 8 trnr trnrH ++ "\n" - blocks = concat $ zipWith (++) - -- entropy terms - [ printBlock "stack" 7 pp2lkey $ stack trnr - , printBlock "mismatch_hairpin" 5 pbb2lkey $ hairpinMM trnr - , printBlock "mismatch_interior" 5 pbb2lkey $ iloopMM trnr - , printBlock "mismatch_interior_1n" 5 pbb2lkey $ iloop1xnMM trnr - , printBlock "mismatch_interior_23" 5 pbb2lkey $ iloop2x3MM trnr - , printBlock "mismatch_multi" 5 pbb2lkey $ multiMM trnr - , printBlock "mismatch_exterior" 5 pbb2lkey $ extMM trnr - , printBlock "dangle5" 5 pb2lkey $ dangle5 trnr - , printBlock "dangle3" 5 pb2lkey $ dangle3 trnr - , printBlock "int11" 5 ppbb2lkey $ iloop1x1 trnr - , printBlock "int21" 5 ppbbb2lkey $ iloop1x2 trnr - , printBlock22 "int22" 4 ppbbbb2lkey $ iloop2x2 trnr - , printLinear "hairpin" 10 $ hairpinL trnr - , printLinear "bulge" 10 $ bulgeL trnr - , printLinear "interior" 10 $ iloopL trnr - ] - -- enthalpy terms - [ printBlockH "stack" 7 pp2lkey $ stack trnrH - , printBlockH "mismatch_hairpin" 5 pbb2lkey $ hairpinMM trnrH - , printBlockH "mismatch_interior" 5 pbb2lkey $ iloopMM trnrH - , printBlockH "mismatch_interior_1n" 5 pbb2lkey $ iloop1xnMM trnrH - , printBlockH "mismatch_interior_23" 5 pbb2lkey $ iloop2x3MM trnrH - , printBlockH "mismatch_multi" 5 pbb2lkey $ multiMM trnrH - , printBlockH "mismatch_exterior" 5 pbb2lkey $ extMM trnrH - , printBlockH "dangle5" 5 pb2lkey $ dangle5 trnrH - , printBlockH "dangle3" 5 pb2lkey $ dangle3 trnrH - , printBlockH "int11" 5 ppbb2lkey $ iloop1x1 trnrH - , printBlockH "int21" 5 ppbbb2lkey $ iloop1x2 trnrH - , printBlock22H "int22" 4 ppbbbb2lkey $ iloop2x2 trnrH - , printLinearH "hairpin" 10 $ hairpinL trnrH - , printLinearH "bulge" 10 $ bulgeL trnrH - , printLinearH "interior" 10 $ iloopL trnrH - ] - - - --- * Helper functions - --- | Show the key of the line, minus the changing last key - -showKey :: [(LKey,Int)] -> String -showKey xs = - " /* " ++ - (concat $ intersperse "," $ init $ (map show ps) ++ (map show ns)) ++ - " */" - where - (ps,ns) = fst $ head xs - --- | Transform from tuple-based keys to a pair of list-based keys. - -type LKey = ([ViennaPair],[Nucleotide]) - -pb2lkey (p1,b1) = ([p1],[b1]) -pbb2lkey (p1,b1,b2) = ([p1],[b1,b2]) -pp2lkey (k1,k2) = ([k1,k2],[]) -ppbb2lkey (p1,p2,b1,b2) = ([p1,p2],[b1,b2]) -ppbbb2lkey (p1,p2,b1,b2,b3) = ([p1,p2],[b1,b2,b3]) -ppbbbb2lkey (p1,p2,b1,b2,b3,b4) = ([p1,p2],[b1,b2,b3,b4]) - --- | Print a block. - -printBlock = printBlockG noNP where - noNP ((ps,ns),v) = not $ any (==vpNP) ps - -printBlockH s = printBlock (s ++ "_enthalpies") - -printBlock22 = printBlockG noNSNPE where - noNSNPE ((ps,ns),v) = not $ any (==vpNP) ps || any (==vpNS) ps || any (==nucE) ns - -printBlock22H s = printBlock22 (s ++ "_enthalpies") - -printBlockG fltr s k tolkey xs' = - let - xs = filter fltr $ map (first tolkey) $ assocs xs' - in - printf "# %s\n" s ++ - (concatMap printLine $ splitEvery k xs) ++ - "\n" - -printLine xs = - concatMap printVal xs ++ " " ++ showKey xs ++ - printf "\n" - -printVal (k,v) - | v > eMax = printf " INF" - | otherwise = printf "%6d" v - --- | A linear block is more boring - -printLinear s k xs' = let xs = assocs xs' in - printf "# %s\n" s ++ - (concatMap (\ys -> concatMap printVal ys ++ "\n") $ splitEvery k xs) ++ - "\n" - -printHairpinAssocs l trnr trnrH = res where - res = concat $ zipWith (\(k,v) vH -> printf "%s %7d %7d\n" (concatMap show k) v vH) xs ys - xs = filter ((==l).length.fst) $ M.assocs $ hairpinLookup trnr - ys = map snd $ filter ((==l).length.fst) $ M.assocs $ hairpinLookup trnrH - -printLinearH s = printLinear (s ++ "_enthalpies") diff --git a/Biobase/Vienna/Import.hs b/Biobase/Vienna/Import.hs new file mode 100644 --- /dev/null +++ b/Biobase/Vienna/Import.hs @@ -0,0 +1,114 @@ +{-# LANGUAGE TypeSynonymInstances #-} +{-# LANGUAGE MultiParamTypeClasses #-} +{-# LANGUAGE FlexibleInstances #-} + +-- | There are two import scenarios: (i) importing from a ViennaRNA parameter +-- file (version 2004 only) and (ii) importing from a Turner2004 data +-- structure. +-- +-- TODO (i) is missing right now + +module Biobase.Vienna.Import where + +import Control.Arrow +import qualified Data.Map as M +import qualified Data.ByteString.Char8 as BS + +import Biobase.Primary +import Biobase.Secondary +import Biobase.Secondary.Vienna +import Data.PrimitiveArray +import qualified Biobase.Turner as T + +import Biobase.Vienna + + + +-- * Transforming a Turner2004 data structure into a Vienna2004 data structure. + +-- | From a 'Turner2004' data structure via lists of key/value pairs. + +fromTurner2004 :: T.Turner2004 -> Vienna2004 +fromTurner2004 turner = Vienna2004 + { stack = convert minPP maxPP $ T.stack turner + , dangle3 = convert minPB maxPB $ T.dangle3 turner + , dangle5 = convert minPB maxPB $ T.dangle5 turner + , hairpinL = convert 0 30 $ T.hairpinL turner + , hairpinMM = convert minPBB maxPBB $ T.hairpinMM turner + , hairpinLookup = M.mapKeys (read . BS.unpack) . M.map deka $ T.hairpinLookup turner + , hairpinGGG = deka $ T.hairpinGGG turner + , hairpinCslope = deka $ T.hairpinCslope turner + , hairpinCintercept = deka $ T.hairpinCintercept turner + , hairpinC3 = deka $ T.hairpinC3 turner + , bulgeL = convert 0 30 $ T.bulgeL turner + , bulgeSingleC = deka $ T.bulgeSingleC turner + , iloop1x1 = convert minPPBB maxPPBB $ T.iloop1x1 turner + , iloop2x1 = convert minPPBBB maxPPBBB $ T.iloop2x1 turner + , iloop2x2 = convert minPPBBBB maxPPBBBB $ T.iloop2x2 turner + , iloopMM = convert minPBB maxPBB $ T.iloopMM turner + , iloop2x3MM = convert minPBB maxPBB $ T.iloop2x3MM turner + , iloop1xnMM = convert minPBB maxPBB $ T.iloop1xnMM turner + , iloopL = convert 0 30 $ T.iloopL turner + , multiMM = convert minPBB maxPBB $ T.multiMM turner + , ninio = deka $ T.ninio turner + , maxNinio = deka $ T.maxNinio turner + , multiOffset = deka $ T.multiOffset turner + , multiNuc = deka $ T.multiNuc turner + , multiHelix = deka $ T.multiHelix turner + , multiAsym = deka $ T.multiAsym turner + , multiStrain = deka $ T.multiStrain turner + , extMM = convert minPBB maxPBB $ T.extMM turner + , coaxial = convert minPP maxPP $ T.coaxial turner + , coaxStack = convert minPBB maxPBB $ T.coaxStack turner + , tStackCoax = convert minPBB maxPBB $ T.tStackCoax turner + , largeLoop = deka $ T.largeLoop turner + , termAU = deka $ T.termAU turner + , intermolecularInit = deka $ T.intermolecularInit turner + } where convert mn mx = fromAssocs mn mx 999999 . map (idxConvert *** deka) . assocs + +-- conversion of indices +-- +-- (roll your eyes) + +class IdxConvert a b where + idxConvert :: a -> b + +instance IdxConvert Pair ViennaPair where + idxConvert = mkViennaPair + +instance IdxConvert Nuc Nuc where + idxConvert = id + +instance IdxConvert Int Int where + idxConvert = id + +instance (IdxConvert a c, IdxConvert b d) => IdxConvert (a,b) (c,d) where + idxConvert = idxConvert *** idxConvert + +instance (IdxConvert a d, IdxConvert b e, IdxConvert c f) => IdxConvert (a,b,c) (d,e,f) where + idxConvert (a,b,c) = (idxConvert a, idxConvert b, idxConvert c) + +instance (IdxConvert al ar, IdxConvert bl br, IdxConvert cl cr, IdxConvert dl dr) => IdxConvert (al,bl,cl,dl) (ar,br,cr,dr) where + idxConvert (a,b,c,d) = (idxConvert a, idxConvert b, idxConvert c, idxConvert d) + +-- | Transform energies to the vienna Int-based variant +-- +-- (which is round (e*100)). + +deka = round . (*100) + +minP = minBound +maxP = maxBound +minPB = (minP,nN) +maxPB = (maxP,nU) +minPP = (minP,minP) +maxPP = (maxP,maxP) +minPBB = (minP,nN,nN) +maxPBB = (maxP,nU,nU) +minPPBB = (minP,minP,(nN,nN)) +maxPPBB = (maxP,maxP,(nU,nU)) +minPPBBB = (minP,minP,(nN,nN,nN)) +maxPPBBB = (maxP,maxP,(nU,nU,nU)) +minPPBBBB = (minP,minP,(nN,nN,nN,nN)) +maxPPBBBB = (maxP,maxP,(nU,nU,nU,nU)) + diff --git a/Biobase/Vienna/Import/Turner.hs b/Biobase/Vienna/Import/Turner.hs deleted file mode 100644 --- a/Biobase/Vienna/Import/Turner.hs +++ /dev/null @@ -1,71 +0,0 @@ -{-# LANGUAGE RecordWildCards #-} - --- | Import data from a Turner table structure. Those can be imported using the --- Turner.Import module. - -module Biobase.Vienna.Import.Turner - ( fromTurner - ) where - -import Control.Arrow -import Data.Tuple.All -import qualified Data.Map as M - -import Biobase.Turner.Tables -import Biobase.Turner -import Data.PrimitiveArray -import Biobase.Constants -import Biobase.RNA - -import Biobase.Vienna --- | Convert from Turner keys to Vienna keys and all values from Double to Int - -fromTurner :: TurnerTables -> ViennaIntTables -fromTurner Turner2004{..} = Turner2004 - { stack = convert pp stack - , dangle3 = convert pb dangle3 - , dangle5 = convert pb dangle5 - , hairpinL = amap f2i hairpinL - , hairpinMM = convert pbb hairpinMM - , hairpinLookup = M.map f2i hairpinLookup - , bulgeL = amap f2i bulgeL - , iloop1x1 = convert uu iloop1x1 - , iloop1x2 = convert uu iloop1x2 - , iloop2x2 = convert uu iloop2x2 - , iloopMM = convert pbb iloopMM - , iloop2x3MM = convert pbb iloop2x3MM - , iloop1xnMM = convert pbb iloop1xnMM - , iloopL = amap f2i iloopL - , multiMM = convert pbb multiMM - , ninio = f2i ninio - , maxNinio = f2i maxNinio - , multiOffset = f2i multiOffset - , multiNuc = f2i multiNuc - , multiHelix = f2i multiHelix - , extMM = convert pbb extMM - , largeLoop = largeLoop * 100 -- scale to decacals - , termAU = f2i termAU - , intermolecularInit = f2i intermolecularInit - } - - - --- * Helper functions. - --- | Vienna values are Int's that have 2-digit precision. - -f2i :: Double -> Int -f2i d = round $ d * 100 - - --- | Deep breath ;-) - -pp = both tuple2Vienna -pb = first tuple2Vienna -pbb t = upd1 (tuple2Vienna $ sel1 t) t -uu t = upd2 (tuple2Vienna $ sel2 t) $ upd1 (tuple2Vienna $ sel1 t) t -both f = first f . second f - --- | Do the conversion, both on keys and values. - -convert fk = fromAssocs minBound maxBound eInf . map (first fk . second f2i) . assocs diff --git a/Biobase/Vienna/Import/ViennaPar.hs b/Biobase/Vienna/Import/ViennaPar.hs deleted file mode 100644 --- a/Biobase/Vienna/Import/ViennaPar.hs +++ /dev/null @@ -1,123 +0,0 @@ -{-# LANGUAGE PatternGuards #-} -{-# LANGUAGE RecordWildCards #-} - -module Biobase.Vienna.Import.ViennaPar - ( importPar - ) where - -import Text.Parsec hiding ((<|>), many, optional) -import Text.Parsec.String -import Text.Parsec.Char -import Text.Parsec.Combinator hiding (optional) -import Control.Applicative -import Data.List -import qualified Data.Map as M - -import Text.Parsec.Numbers -import Biobase.Constants -import Biobase.RNA -import Biobase.Turner.Tables -import Data.PrimitiveArray - -import Biobase.Vienna - - - --- | Imports Vienna tables from a given string. - -importPar :: String -> (ViennaIntTables,ViennaIntTables) -importPar s - | Right _ <- p = foldr updateTables (trnr,trnrH) bs - | Left err <- p = error $ show err - where - p = parse blocks "(stdin)" s - Right bs = p - (bgs,bhs) = partition (not . isHblock) bs - trnr = foldr updateTable emptyTables bgs - trnrH = foldr updateTable emptyTables bhs - --- | Apply all parsed blocks to a Turner2004 structure. - -updateTable :: Block -> ViennaIntTables -> ViennaIntTables -updateTable Block{..} trnr -- @Turner2004{..} - | bhdr =? "stack" = trnr{stack = fromAssocs minBound maxBound z $ zip pp ints} - | bhdr =? "dangle3" = trnr{dangle3 = fromAssocs minBound maxBound z $ zip pb ints} - | bhdr =? "dangle5" = trnr{dangle5 = fromAssocs minBound maxBound z $ zip pb ints} - | bhdr =? "hairpin" = trnr{hairpinL = fromList 0 30 ints} - | bhdr =? "mismatch_hairpin" = trnr{hairpinMM = fromAssocs minBound maxBound z $ zip pbb ints} - | bhdr =? "bulge" = trnr{bulgeL = fromList 0 30 ints} - | bhdr =? "int11" = trnr{iloop1x1 = fromAssocs minBound maxBound z $ zip ppbb ints} - | bhdr =? "int21" = trnr{iloop1x2 = fromAssocs minBound maxBound z $ zip ppbbb ints} - | bhdr =? "int22" = trnr{iloop2x2 = fromAssocs minBound maxBound z $ zip ppbbbb ints} - | bhdr =? "mismatch_interior" = trnr{iloopMM = fromAssocs minBound maxBound z $ zip pbb ints} - | bhdr =? "mismatch_interior_23" = trnr{iloop2x3MM = fromAssocs minBound maxBound z $ zip pbb ints} - | bhdr =? "mismatch_interior_1n" = trnr{iloop1xnMM = fromAssocs minBound maxBound z $ zip pbb ints} - | bhdr =? "interior" = trnr{iloopL = fromList 0 30 ints} - | bhdr =? "mismatch_multi" = trnr{multiMM = fromAssocs minBound maxBound z $ zip pbb ints} - | bhdr =? "mismatch_exterior" = trnr{extMM = fromAssocs minBound maxBound z $ zip pbb ints} - | otherwise = trnr -- unknown block! -updateTable ABlock{..} trnr - | otherwise = trnr -- CORRECT! - --- | update with info where no separation between G/H was done. - -updateTables Block{..} (trnr,trnrH) - | bhdr =? "ML_params" - = ( trnr {multiNuc = ints!!0, multiOffset = ints!!2, multiHelix = ints!!4} - , trnrH{multiNuc = ints!!1, multiOffset = ints!!3, multiHelix = ints!!5} - ) - | bhdr =? "NINIO" - = ( trnr {ninio = ints!!0, maxNinio = ints!!2} - , trnrH {ninio = ints!!1} - ) - | bhdr =? "Misc" - = ( trnr {intermolecularInit = ints!!0, termAU = ints!!2} - , trnrH {intermolecularInit = ints!!1, termAU = ints!!3} - ) - | otherwise = (trnr,trnrH) -updateTables ABlock{..} (trnr,trnrH) - | bhdr =? "Triloops" || bhdr =? "Tetraloops" || bhdr =? "Hexaloops" - = ( trnr {hairpinLookup = hairpinLookup trnr `M.union` (M.fromList $ map (\(k,v,w) -> (s2ns k,v)) ascs)} - , trnrH {hairpinLookup = hairpinLookup trnrH `M.union` (M.fromList $ map (\(k,v,w) -> (s2ns k,w)) ascs)} - ) - | otherwise = (trnr,trnrH) - -pp = [(x,y) | x<-cgnsP,y<-cgnsP] -pb = [(x,y) | x<-cgnsP,y<-eacgu] -pbb = [(x,y,z) | x<-cgnsP,y<-eacgu,z<-eacgu] -ppbb = [(p1,p2,b1,b2) | p1<-cgnsP,p2<-cgnsP,b1<-eacgu,b2<-eacgu] -ppbbb = [(p1,p2,b1,b2,b3) | p1<-cgnsP,p2<-cgnsP,b1<-eacgu,b2<-eacgu,b3<-eacgu] -ppbbbb = [(p1,p2,b1,b2,b3,b4) | p1<-cguaP,p2<-cguaP,b1<-acgu,b2<-acgu,b3<-acgu,b4<-acgu] -z = eInf --- xs is the block header name, ys the constant string -xs =? ys = xs == ys || xs == ys++"_enthalpies" -- and $ zipWith (==) xs ys -s2ns = map charToNucleotide - --- * Simple parser for the vienna 2.0 format. - -isHblock :: Block -> Bool -isHblock b = "enthalpies" `elem` (tails $ bhdr b) - -data Block - = Block {bhdr :: String, ints :: [Int]} - | ABlock {bhdr :: String, ascs :: [(String,Int,Int)]} - deriving (Show) - -blocks :: GenParser Char st [Block] -blocks = vrna2 *> spaces *> (try assocBlock <|> try block) `sepEndBy1` spaces <* string "#END" <* spaces <* eof - -vrna2 = string "## RNAfold parameter file v2.0" - -block :: GenParser Char st Block -block = Block <$> header <* spaces <*> num `sepEndBy1` (try comment <|> spaces) where - num = ((eInf <$ string "INF") <|> parseIntegral) - -assocBlock :: GenParser Char st Block -assocBlock = ABlock <$> header <* spaces <*> asc `sepEndBy1` spaces where - asc = (,,) <$> (many1 $ oneOf "ACGU") <* spaces <*> parseIntegral <* spaces <*> parseIntegral - -header :: GenParser Char st String -header = char '#' *> space *> (alphaNum <|> char '_') `manyTill` newline - -comment :: GenParser Char st () -comment = const () <$ spaces <*> between (string "/*") (string "*/") (many $ noneOf "/*") <* spaces diff --git a/Biobase/Vienna/Modification/NonStandard.hs b/Biobase/Vienna/Modification/NonStandard.hs deleted file mode 100644 --- a/Biobase/Vienna/Modification/NonStandard.hs +++ /dev/null @@ -1,121 +0,0 @@ - --- | This module provides facilities to modify values in the tables and return --- the modified tables. The main reason for the modules' existence are the 'E' --- nucleotides and 'NS' base pairs used by the ViennaRNA package to denote --- unknown or missing nucleotides. For each table type, we have a small --- function. - -module Biobase.Vienna.Modification.NonStandard - ( nonStandardMax - ) where - -import Biobase.RNA -import Biobase.Vienna -import Biobase.Turner.Tables -import Data.Ix.Tuple -import Biobase.Constants -import Biobase.Types.Energy - -import Data.PrimitiveArray - - --- | Each table-changing operation makes the promise that all individual --- changes in a batch are independent of the changes in the same batch - -changeTable f tbl = fromAssocs l u z . map (f tbl) $ assocs tbl where - (l,u) = bounds tbl - z = Energy eInf - - - --- |* Replace each occurrance of a value with a strange key according to this --- rule. The rule is to take the maximum over all sane keys in the --- neighborhood. Yes, this takes long... - -fPPBBBBmax tbl (k@(p1,p2,b1,b2,b3,b4),v) - | p1==vpNP || p2==vpNP = (k,v) -- don't do anything - | otherwise = (k,maximum' - [ tbl ! (p1n,p2n,b1n,b2n,b3n,b4n) - | p1n <- genKeyP p1 - , p2n <- genKeyP p2 - , b1n <- genKeyB b1 - , b2n <- genKeyB b2 - , b3n <- genKeyB b3 - , b4n <- genKeyB b4 - ]) - -fPPBBBmax tbl (k@(p1,p2,b1,b2,b3),v) - | p1==vpNP || p2==vpNP = (k,v) - | otherwise = (k,maximum' - [ tbl ! (p1n,p2n,b1n,b2n,b3n) - | p1n <- genKeyP p1 - , p2n <- genKeyP p2 - , b1n <- genKeyB b1 - , b2n <- genKeyB b2 - , b3n <- genKeyB b3 - ]) - -fPPBBmax tbl (k@(p1,p2,b1,b2),v) - | p1==vpNP || p2==vpNP = (k,v) - | otherwise = (k,maximum' - [ tbl ! (p1n,p2n,b1n,b2n) - | p1n <- genKeyP p1 - , p2n <- genKeyP p2 - , b1n <- genKeyB b1 - , b2n <- genKeyB b2 - ]) - -fPPmax tbl (k@(p1,p2),v) - | p1==vpNP || p2==vpNP = (k,v) - | otherwise = (k,maximum' - [ tbl ! (p1n,p2n) - | p1n <- genKeyP p1 - , p2n <- genKeyP p2 - ]) - -fPBBmax tbl (k@(p1,b1,b2),v) - | p1==vpNP = (k,v) - | otherwise = (k,maximum' - [ tbl ! (p1n,b1n,b2n) - | p1n <- genKeyP p1 - , b1n <- genKeyB b1 - , b2n <- genKeyB b2 - ]) - -fPBmax tbl (k@(p1,b1),v) - | p1==vpNP = (k,v) - | otherwise = (k,maximum' - [ tbl ! (p1n,b1n) - | p1n <- genKeyP p1 - , b1n <- genKeyB b1 - ]) - -maximum' = Energy . maximum . map unEnergy - - --- * Generate keys. If the key is of the non-standard kind, then we go fishing, --- otherwise we keep the key itself. - -genKeyP k = if k==vpNS then cguaP else [k] -genKeyB k = if k==nucE then acgu else [k] - - - --- | The max operation applied to all relevant tables. (This serves as a --- pointer, which tables to manipulate). - -nonStandardMax :: ViennaEnergyTables -> ViennaEnergyTables -nonStandardMax tbl = tbl - { iloop1x1 = changeTable fPPBBmax $ iloop1x1 tbl - , iloop1x2 = changeTable fPPBBBmax $ iloop1x2 tbl - , iloop2x2 = changeTable fPPBBBBmax $ iloop2x2 tbl - , hairpinMM = changeTable fPBBmax $ hairpinMM tbl - , iloopMM = changeTable fPBBmax $ iloopMM tbl - , iloop1xnMM = changeTable fPBBmax $ iloop1xnMM tbl - , iloop2x3MM = changeTable fPBBmax $ iloop2x3MM tbl - , multiMM = changeTable fPBBmax $ multiMM tbl - , extMM = changeTable fPBBmax $ extMM tbl - , dangle3 = changeTable fPBmax $ dangle3 tbl - , dangle5 = changeTable fPBmax $ dangle5 tbl - , stack = changeTable fPPmax $ stack tbl - } diff --git a/Biobase/Vienna/Modification/Partition.hs b/Biobase/Vienna/Modification/Partition.hs deleted file mode 100644 --- a/Biobase/Vienna/Modification/Partition.hs +++ /dev/null @@ -1,51 +0,0 @@ - --- | Small module for converting Vienna energy tables to partition function --- value tables. --- --- Temperature scaling should happen on the level of energy tables, followed by --- conversion here. --- --- TODO after the switch to the Energy type, change too, the partitionTables --- generation - -module Biobase.Vienna.Modification.Partition - ( partitionTables - ) where - -import Biobase.Types.Partition -import Biobase.Types.Energy -import Biobase.Turner.Tables -import Biobase.Vienna -import Biobase.Constants - - --- Testing - -{- -import Biobase.Vienna.Default -import Data.PrimitiveArray -import Debug.Trace.Tools -import Biobase.RNA -import Biobase.Types.Ring - -(g,h) = turner2004GH - --- x = toList $ stack $ partitionTables 37 g -x = {- toList $ -} (stack $ partitionTables 37 g) ! (vpGC,vpGC) --} - --- | Create partition tables out of normal energy tables. Note that these --- values are not normalized. An additional term 1/Z(1/kt) would be required --- which is missing until we are done calculating the partition function. --- --- All energy contributions are rescaled from dekacals back to kcal/mol. --- --- We explicitly set all probabilities =0 where the energy is >= eMax. - -partitionTables :: Temperature -> ViennaEnergyTables -> ViennaPartitionTables -partitionTables tempe trnr = dmap f trnr where - kt = (tempe + kelvinC0) * gasconst - -- convert energy into probability; encapsulate as a (logFloat) partition - f (Energy e') = {- traceVal (show (e',e,p)) -} p where - e = fromIntegral e' / 100 - p = if e' >= eMax then Partition 0 else Partition . exp $ -e / kt -- can NOT use mkPartition as these values are NOT NORMALIZED diff --git a/Biobase/Vienna/Modification/Temperature.hs b/Biobase/Vienna/Modification/Temperature.hs deleted file mode 100644 --- a/Biobase/Vienna/Modification/Temperature.hs +++ /dev/null @@ -1,34 +0,0 @@ - --- | Given entropy and enthalpy sets, allow modification of the folding --- temperature (from the default 37 Celsius) - -module Biobase.Vienna.Modification.Temperature - ( adjustTemperature - ) where - -import Biobase.Vienna -import Biobase.Turner.Tables -import Biobase.Constants - - - --- temperature scaling is a generalized zip: let g and h be a scalar, t the --- temperature. Then: g_t = h - (h-g)*((t+k_0)/t_m). Where k_0 = 273.15 (Kelvin --- of 37 Celsius) and t_m = 37+k_0 --- --- TODO abstract over table type? --- --- TODO this does not take into account that dangles are supposed to _always_ --- be beneficial. We should therefor transform the energies and then apply 'min --- 0' onto all dangle types. --- --- TODO use EnergyTables (Int is just for im-/export) - -adjustTemperature :: ViennaIntTables -> ViennaIntTables -> Temperature -> ViennaIntTables -adjustTemperature trnrG trnrH cels = dZipWith f trnrG trnrH where - f vG vH = - let g = fromIntegral vG - h = fromIntegral vH - k_0 = kelvinC0 - t_m = 37 + k_0 - in round $ h - (h-g) * ((cels+k_0)/t_m) diff --git a/BiobaseVienna.cabal b/BiobaseVienna.cabal --- a/BiobaseVienna.cabal +++ b/BiobaseVienna.cabal @@ -1,52 +1,46 @@ name: BiobaseVienna -version: 0.0.2.3 +version: 0.1.0.0 author: Christian Hoener zu Siederdissen maintainer: choener@tbi.univie.ac.at -copyright: Christian Hoener zu Siederdissen, 2010 +homepage: http://www.tbi.univie.ac.at/~choener/ +copyright: Christian Hoener zu Siederdissen, 2010,2011 category: Bioinformatics -synopsis: (deprecated) ViennaRNA parameter library +synopsis: Import Vienna energy parameters license: GPL-3 license-file: LICENSE build-type: Simple stability: experimental -cabal-version: >= 1.4.0 +cabal-version: >= 1.6.0 description: - Import and export of ViennaRNA-style parameters for RNA - secondary structure prediction. - -extra-source-files: - parfiles/Turner2004GH.par, - templates/cheader + Importer and Exporter for Vienna energy files. Allows + converting Turner parameter files to Vienna parameter files. + . + This is the 2011 post-library split version, hence not + deprecated anymore. library build-depends: - base >=4 && <5, + base >3 && <5, bytestring, + bytestring-lexing, containers, - file-embed >=0.0.3, - parsec >=3, - split >=0.1.2, - tuple >=0.2.0.1, - vector >=0.7 && <0.8, - directory >=1, - - PrimitiveArray >=0.0.2 && <0.0.3, - ParsecTools >=0.0.2 && <0.0.3, - HsTools >=0.0.1.1, - Biobase >=0.0.2, - BiobaseTurner >=0.0.2, - BiobaseTypes >=0.0.2 - + filepath, + iteratee, + split, + BiobaseTurner >= 0.1.1, + BiobaseXNA >= 0.5.1, + PrimitiveArray exposed-modules: Biobase.Vienna - Biobase.Vienna.Import.Turner - Biobase.Vienna.Import.ViennaPar - Biobase.Vienna.Export.ViennaPar - Biobase.Vienna.Export.ViennaC - Biobase.Vienna.Modification.NonStandard - Biobase.Vienna.Modification.Temperature - Biobase.Vienna.Modification.Partition - Biobase.Vienna.Default + Biobase.Vienna.Export + Biobase.Vienna.Import + ghc-options: + -O2 +executable ViennaConverter + build-depends: + cmdargs == 0.8.* + main-is: + ViennaConverter.hs ghc-options: -O2 diff --git a/ViennaConverter.hs b/ViennaConverter.hs new file mode 100644 --- /dev/null +++ b/ViennaConverter.hs @@ -0,0 +1,68 @@ +{-# LANGUAGE RecordWildCards #-} +{-# LANGUAGE DeriveDataTypeable #-} + +-- | Convert Turner parameter files into Vienna energy files. Either into a +-- ".par" file (which is used by the Haskell RNAFold as well) or multiple ".C" +-- and ".H" files for inclusion into the ViennaRNA package. + +module Main where + +import System.Console.CmdArgs + +import Biobase.Turner.Import +import Biobase.Vienna.Export +import Biobase.Vienna.Import + +{- +import Biobase.Primary +import Biobase.Secondary +import Biobase.Secondary.Vienna +import Data.PrimitiveArray +import Data.PrimitiveArray.Ix +import Biobase.Vienna +-} + + + +data Options = Options + { dir :: FilePath + , dna :: Bool + } deriving (Show,Data,Typeable) + +options = Options + { dir = def &= args + , dna = False &= help "apply dna prefix (default: false)" + } + +main :: IO () +main = do + Options{..} <- cmdArgs options + let prefix = if dna then "dna" else "" + trnr <- fmap fromTurner2004 $ fromDir dir prefix "dat" + trnrH <- fmap fromTurner2004 $ fromDir dir prefix "dh" + putStrLn $ asPar trnr trnrH + --mapM_ print $ int22symmetry $ iloop2x2 trnr + return () + +{- symmetry checking +int22symmetry :: PrimArray I22K Int -> [( (I22K,Int) , (I22K,Int) )] +int22symmetry arr = filter (\(a,b) -> snd a /= snd b) + . map (\k -> ((k,arr!k),(swp k, arr! swp k))) + $ keys + where + keys = [ (p1,p2,(b1,b2,b3,b4)) + | p1 <- cguaP, p2 <- cguaP + , b1 <- acgu, b2 <- acgu, b3 <- acgu, b4 <- acgu + ] + swp (p1,p2,(b1,b2,b3,b4)) = ( p2 + , p1 + , ( b3 + , b4 + , b1 + , b2 + ) + ) + +type I22K = (ViennaPair,ViennaPair,(Nuc,Nuc,Nuc,Nuc)) + +-} diff --git a/parfiles/Turner2004GH.par b/parfiles/Turner2004GH.par deleted file mode 100644 --- a/parfiles/Turner2004GH.par +++ /dev/null @@ -1,8135 +0,0 @@ -## RNAfold parameter file v2.0 - -# stack - -240 -330 -210 -140 -210 -210 -140 /* CG */ - -330 -340 -250 -150 -220 -240 -150 /* GC */ - -210 -250 130 -50 -140 -130 130 /* GU */ - -140 -150 -50 30 -60 -100 30 /* UG */ - -210 -220 -140 -60 -110 -90 -60 /* AU */ - -210 -240 -130 -100 -90 -130 -90 /* UA */ - -140 -150 130 30 -60 -90 130 /* NS */ - -# stack_enthalpies - -1060 -1340 -1210 -560 -1050 -1040 -560 /* CG */ - -1340 -1490 -1260 -830 -1140 -1240 -830 /* GC */ - -1210 -1260 -1460 -1350 -880 -1280 -880 /* GU */ - -560 -830 -1350 -930 -320 -700 -320 /* UG */ - -1050 -1140 -880 -320 -940 -680 -320 /* AU */ - -1040 -1240 -1280 -700 -680 -770 -680 /* UA */ - -560 -830 -880 -320 -320 -680 -320 /* NS */ - -# mismatch_hairpin - -80 -100 -110 -100 -80 /* CG,E */ - -140 -150 -150 -140 -150 /* CG,A */ - -80 -100 -110 -100 -80 /* CG,C */ - -150 -230 -150 -240 -150 /* CG,G */ - -100 -100 -140 -100 -210 /* CG,U */ - -50 -110 -70 -110 -50 /* GC,E */ - -110 -110 -150 -130 -150 /* GC,A */ - -50 -110 -70 -110 -50 /* GC,C */ - -150 -250 -150 -220 -150 /* GC,G */ - -100 -110 -100 -110 -160 /* GC,U */ - 20 20 -20 -10 -20 /* GU,E */ - 20 20 -50 -30 -50 /* GU,A */ - -10 -10 -20 -10 -20 /* GU,C */ - -50 -100 -50 -110 -50 /* GU,G */ - -10 -10 -30 -10 -100 /* GU,U */ - 0 -20 -10 -20 0 /* UG,E */ - -30 -50 -30 -60 -30 /* UG,A */ - 0 -20 -10 -20 0 /* UG,C */ - -30 -90 -30 -110 -30 /* UG,G */ - -10 -20 -10 -20 -90 /* UG,U */ - -10 -10 -20 -10 -20 /* AU,E */ - -30 -30 -50 -30 -50 /* AU,A */ - -10 -10 -20 -10 -20 /* AU,C */ - -50 -120 -50 -110 -50 /* AU,G */ - -10 -10 -30 -10 -120 /* AU,U */ - 0 -20 -10 -20 0 /* UA,E */ - -30 -50 -30 -50 -30 /* UA,A */ - 0 -20 -10 -20 0 /* UA,C */ - -30 -150 -30 -150 -30 /* UA,G */ - -10 -20 -10 -20 -90 /* UA,U */ - 20 20 -10 -10 0 /* NS,E */ - 20 20 -30 -30 -30 /* NS,A */ - 0 -10 -10 -10 0 /* NS,C */ - -30 -90 -30 -110 -30 /* NS,G */ - -10 -10 -10 -10 -90 /* NS,U */ - -# mismatch_hairpin_enthalpies - 560 -570 560 -560 -270 /* CG,E */ - -560 -910 -560 -560 -560 /* CG,A */ - -270 -570 -340 -570 -270 /* CG,C */ - 560 -1400 560 -920 -560 /* CG,G */ - -530 -570 -530 -570 -1440 /* CG,U */ - 50 -520 50 -560 -400 /* GC,E */ - -400 -520 -400 -560 -400 /* GC,A */ - 50 -720 50 -720 -420 /* GC,C */ - -400 -1290 -400 -620 -400 /* GC,G */ - -30 -720 -30 -720 -1080 /* GC,U */ - 970 140 970 140 570 /* GU,E */ - 570 30 570 20 570 /* GU,A */ - 970 140 970 140 340 /* GU,C */ - 570 -270 570 20 570 /* GU,G */ - 830 140 830 140 -50 /* GU,U */ - 230 100 230 220 190 /* UG,E */ - -110 -110 -260 -520 -260 /* UG,A */ - 190 -60 -140 -60 190 /* UG,C */ - 220 100 -260 220 -260 /* UG,G */ - 230 -60 230 -60 -70 /* UG,U */ - 970 140 970 140 570 /* AU,E */ - 570 -20 570 20 570 /* AU,A */ - 970 140 970 140 340 /* AU,C */ - 570 -520 570 20 570 /* AU,G */ - 830 140 830 140 -380 /* AU,U */ - 230 -30 230 -60 190 /* UA,E */ - -30 -30 -260 -520 -260 /* UA,A */ - 190 -60 -140 -60 190 /* UA,C */ - -260 -590 -260 -520 -260 /* UA,G */ - 230 -60 230 -60 -70 /* UA,U */ - 970 140 970 220 570 /* NS,E */ - 570 30 570 20 570 /* NS,A */ - 970 140 970 140 340 /* NS,C */ - 570 100 570 220 570 /* NS,G */ - 830 140 830 140 -50 /* NS,U */ - -# mismatch_interior - 0 0 0 0 0 /* CG,E */ - 0 0 0 -80 0 /* CG,A */ - 0 0 0 0 0 /* CG,C */ - 0 -100 0 -100 0 /* CG,G */ - 0 0 0 0 -60 /* CG,U */ - 0 0 0 0 0 /* GC,E */ - 0 0 0 -80 0 /* GC,A */ - 0 0 0 0 0 /* GC,C */ - 0 -100 0 -100 0 /* GC,G */ - 0 0 0 0 -60 /* GC,U */ - 70 70 70 70 70 /* GU,E */ - 70 70 70 -10 70 /* GU,A */ - 70 70 70 70 70 /* GU,C */ - 70 -30 70 -30 70 /* GU,G */ - 70 70 70 70 10 /* GU,U */ - 70 70 70 70 70 /* UG,E */ - 70 70 70 -10 70 /* UG,A */ - 70 70 70 70 70 /* UG,C */ - 70 -30 70 -30 70 /* UG,G */ - 70 70 70 70 10 /* UG,U */ - 70 70 70 70 70 /* AU,E */ - 70 70 70 -10 70 /* AU,A */ - 70 70 70 70 70 /* AU,C */ - 70 -30 70 -30 70 /* AU,G */ - 70 70 70 70 10 /* AU,U */ - 70 70 70 70 70 /* UA,E */ - 70 70 70 -10 70 /* UA,A */ - 70 70 70 70 70 /* UA,C */ - 70 -30 70 -30 70 /* UA,G */ - 70 70 70 70 10 /* UA,U */ - 70 70 70 70 70 /* NS,E */ - 70 70 70 -10 70 /* NS,A */ - 70 70 70 70 70 /* NS,C */ - 70 -30 70 -30 70 /* NS,G */ - 70 70 70 70 10 /* NS,U */ - -# mismatch_interior_enthalpies - 280 0 0 280 0 /* CG,E */ - 0 0 0 -340 0 /* CG,A */ - 0 0 0 0 0 /* CG,C */ - 280 -760 0 280 0 /* CG,G */ - 0 0 0 0 -580 /* CG,U */ - 280 0 0 280 0 /* GC,E */ - 0 0 0 -340 0 /* GC,A */ - 0 0 0 0 0 /* GC,C */ - 280 -760 0 280 0 /* GC,G */ - 0 0 0 0 -580 /* GC,U */ - 790 500 500 790 500 /* GU,E */ - 500 500 500 170 500 /* GU,A */ - 500 500 500 500 500 /* GU,C */ - 790 -260 500 790 500 /* GU,G */ - 500 500 500 500 -80 /* GU,U */ - 790 500 500 790 500 /* UG,E */ - 500 500 500 170 500 /* UG,A */ - 500 500 500 500 500 /* UG,C */ - 790 -260 500 790 500 /* UG,G */ - 500 500 500 500 -80 /* UG,U */ - 790 500 500 790 500 /* AU,E */ - 500 500 500 170 500 /* AU,A */ - 500 500 500 500 500 /* AU,C */ - 790 -260 500 790 500 /* AU,G */ - 500 500 500 500 -80 /* AU,U */ - 790 500 500 790 500 /* UA,E */ - 500 500 500 170 500 /* UA,A */ - 500 500 500 500 500 /* UA,C */ - 790 -260 500 790 500 /* UA,G */ - 500 500 500 500 -80 /* UA,U */ - 790 500 500 790 500 /* NS,E */ - 500 500 500 170 500 /* NS,A */ - 500 500 500 500 500 /* NS,C */ - 790 -260 500 790 500 /* NS,G */ - 500 500 500 500 -80 /* NS,U */ - -# mismatch_interior_1n - 0 0 0 0 0 /* CG,E */ - 0 0 0 0 0 /* CG,A */ - 0 0 0 0 0 /* CG,C */ - 0 0 0 0 0 /* CG,G */ - 0 0 0 0 0 /* CG,U */ - 0 0 0 0 0 /* GC,E */ - 0 0 0 0 0 /* GC,A */ - 0 0 0 0 0 /* GC,C */ - 0 0 0 0 0 /* GC,G */ - 0 0 0 0 0 /* GC,U */ - 70 70 70 70 70 /* GU,E */ - 70 70 70 70 70 /* GU,A */ - 70 70 70 70 70 /* GU,C */ - 70 70 70 70 70 /* GU,G */ - 70 70 70 70 70 /* GU,U */ - 70 70 70 70 70 /* UG,E */ - 70 70 70 70 70 /* UG,A */ - 70 70 70 70 70 /* UG,C */ - 70 70 70 70 70 /* UG,G */ - 70 70 70 70 70 /* UG,U */ - 70 70 70 70 70 /* AU,E */ - 70 70 70 70 70 /* AU,A */ - 70 70 70 70 70 /* AU,C */ - 70 70 70 70 70 /* AU,G */ - 70 70 70 70 70 /* AU,U */ - 70 70 70 70 70 /* UA,E */ - 70 70 70 70 70 /* UA,A */ - 70 70 70 70 70 /* UA,C */ - 70 70 70 70 70 /* UA,G */ - 70 70 70 70 70 /* UA,U */ - 70 70 70 70 70 /* NS,E */ - 70 70 70 70 70 /* NS,A */ - 70 70 70 70 70 /* NS,C */ - 70 70 70 70 70 /* NS,G */ - 70 70 70 70 70 /* NS,U */ - -# mismatch_interior_1n_enthalpies - 0 0 0 0 0 /* CG,E */ - 0 0 0 0 0 /* CG,A */ - 0 0 0 0 0 /* CG,C */ - 0 0 0 0 0 /* CG,G */ - 0 0 0 0 0 /* CG,U */ - 0 0 0 0 0 /* GC,E */ - 0 0 0 0 0 /* GC,A */ - 0 0 0 0 0 /* GC,C */ - 0 0 0 0 0 /* GC,G */ - 0 0 0 0 0 /* GC,U */ - 500 500 500 500 500 /* GU,E */ - 500 500 500 500 500 /* GU,A */ - 500 500 500 500 500 /* GU,C */ - 500 500 500 500 500 /* GU,G */ - 500 500 500 500 500 /* GU,U */ - 500 500 500 500 500 /* UG,E */ - 500 500 500 500 500 /* UG,A */ - 500 500 500 500 500 /* UG,C */ - 500 500 500 500 500 /* UG,G */ - 500 500 500 500 500 /* UG,U */ - 500 500 500 500 500 /* AU,E */ - 500 500 500 500 500 /* AU,A */ - 500 500 500 500 500 /* AU,C */ - 500 500 500 500 500 /* AU,G */ - 500 500 500 500 500 /* AU,U */ - 500 500 500 500 500 /* UA,E */ - 500 500 500 500 500 /* UA,A */ - 500 500 500 500 500 /* UA,C */ - 500 500 500 500 500 /* UA,G */ - 500 500 500 500 500 /* UA,U */ - 500 500 500 500 500 /* NS,E */ - 500 500 500 500 500 /* NS,A */ - 500 500 500 500 500 /* NS,C */ - 500 500 500 500 500 /* NS,G */ - 500 500 500 500 500 /* NS,U */ - -# mismatch_interior_23 - 0 0 0 0 0 /* CG,E */ - 0 0 0 -50 0 /* CG,A */ - 0 0 0 0 0 /* CG,C */ - 0 -110 0 -70 0 /* CG,G */ - 0 0 0 0 -30 /* CG,U */ - 0 0 0 0 0 /* GC,E */ - 0 0 0 0 0 /* GC,A */ - 0 0 0 0 0 /* GC,C */ - 0 -120 0 -70 0 /* GC,G */ - 0 0 0 0 -30 /* GC,U */ - 70 70 70 70 70 /* GU,E */ - 70 70 70 70 70 /* GU,A */ - 70 70 70 70 70 /* GU,C */ - 70 -40 70 0 70 /* GU,G */ - 70 70 70 70 40 /* GU,U */ - 70 70 70 70 70 /* UG,E */ - 70 70 70 20 70 /* UG,A */ - 70 70 70 70 70 /* UG,C */ - 70 -40 70 0 70 /* UG,G */ - 70 70 70 70 40 /* UG,U */ - 70 70 70 70 70 /* AU,E */ - 70 70 70 70 70 /* AU,A */ - 70 70 70 70 70 /* AU,C */ - 70 -40 70 0 70 /* AU,G */ - 70 70 70 70 40 /* AU,U */ - 70 70 70 70 70 /* UA,E */ - 70 70 70 20 70 /* UA,A */ - 70 70 70 70 70 /* UA,C */ - 70 -40 70 0 70 /* UA,G */ - 70 70 70 70 40 /* UA,U */ - 70 70 70 70 70 /* NS,E */ - 70 70 70 70 70 /* NS,A */ - 70 70 70 70 70 /* NS,C */ - 70 -40 70 0 70 /* NS,G */ - 70 70 70 70 40 /* NS,U */ - -# mismatch_interior_23_enthalpies - 0 0 0 0 0 /* CG,E */ - 0 0 0 -570 0 /* CG,A */ - 0 0 0 0 0 /* CG,C */ - 0 -860 0 -900 0 /* CG,G */ - 0 0 0 0 -640 /* CG,U */ - 0 0 0 0 0 /* GC,E */ - 0 0 0 0 0 /* GC,A */ - 0 0 0 0 0 /* GC,C */ - 0 -1090 0 -900 0 /* GC,G */ - 0 0 0 0 -640 /* GC,U */ - 500 500 500 500 500 /* GU,E */ - 500 500 500 500 500 /* GU,A */ - 500 500 500 500 500 /* GU,C */ - 500 -580 500 -400 500 /* GU,G */ - 500 500 500 500 -140 /* GU,U */ - 500 500 500 500 500 /* UG,E */ - 500 500 500 -60 500 /* UG,A */ - 500 500 500 500 500 /* UG,C */ - 500 -360 500 -400 500 /* UG,G */ - 500 500 500 500 -140 /* UG,U */ - 500 500 500 500 500 /* AU,E */ - 500 500 500 500 500 /* AU,A */ - 500 500 500 500 500 /* AU,C */ - 500 -580 500 -400 500 /* AU,G */ - 500 500 500 500 -140 /* AU,U */ - 500 500 500 500 500 /* UA,E */ - 500 500 500 -60 500 /* UA,A */ - 500 500 500 500 500 /* UA,C */ - 500 -360 500 -400 500 /* UA,G */ - 500 500 500 500 -140 /* UA,U */ - 500 500 500 500 500 /* NS,E */ - 500 500 500 500 500 /* NS,A */ - 500 500 500 500 500 /* NS,C */ - 500 -360 500 -400 500 /* NS,G */ - 500 500 500 500 -140 /* NS,U */ - -# mismatch_multi - -80 -100 -110 -100 -80 /* CG,E */ - -140 -150 -150 -140 -150 /* CG,A */ - -80 -100 -110 -100 -80 /* CG,C */ - -140 -140 -150 -160 -150 /* CG,G */ - -100 -100 -140 -100 -120 /* CG,U */ - -50 -110 -70 -110 -50 /* GC,E */ - -110 -110 -150 -130 -150 /* GC,A */ - -50 -110 -70 -110 -50 /* GC,C */ - -140 -160 -150 -140 -150 /* GC,G */ - -70 -110 -100 -110 -70 /* GC,U */ - -30 -30 -70 -60 -60 /* GU,E */ - -30 -30 -100 -80 -100 /* GU,A */ - -60 -60 -70 -60 -70 /* GU,C */ - -60 -60 -100 -80 -100 /* GU,G */ - -60 -60 -80 -60 -60 /* GU,U */ - -50 -50 -60 -70 -50 /* UG,E */ - -80 -100 -80 -110 -80 /* UG,A */ - -50 -70 -60 -70 -50 /* UG,C */ - -50 -50 -80 -80 -80 /* UG,G */ - -50 -70 -60 -70 -50 /* UG,U */ - -60 -60 -70 -60 -70 /* AU,E */ - -80 -80 -100 -80 -100 /* AU,A */ - -60 -60 -70 -60 -70 /* AU,C */ - -80 -80 -100 -80 -100 /* AU,G */ - -60 -60 -80 -60 -80 /* AU,U */ - -50 -70 -60 -70 -50 /* UA,E */ - -80 -100 -80 -110 -80 /* UA,A */ - -50 -70 -60 -70 -50 /* UA,C */ - -80 -110 -80 -120 -80 /* UA,G */ - -50 -70 -60 -70 -50 /* UA,U */ - -30 -30 -60 -60 -50 /* NS,E */ - -30 -30 -80 -80 -80 /* NS,A */ - -50 -60 -60 -60 -50 /* NS,C */ - -50 -50 -80 -80 -80 /* NS,G */ - -50 -60 -60 -60 -50 /* NS,U */ - -# mismatch_multi_enthalpies - -270 -570 -340 -560 -270 /* CG,E */ - -560 -910 -560 -560 -560 /* CG,A */ - -270 -570 -340 -570 -270 /* CG,C */ - -560 -820 -560 -920 -560 /* CG,G */ - -530 -570 -530 -570 -860 /* CG,U */ - 50 -520 50 -560 -400 /* GC,E */ - -400 -520 -400 -560 -400 /* GC,A */ - 50 -720 50 -720 -420 /* GC,C */ - -400 -710 -400 -620 -400 /* GC,G */ - -30 -720 -30 -720 -500 /* GC,U */ - 600 -60 600 -230 200 /* GU,E */ - 200 -340 200 -350 200 /* GU,A */ - 600 -230 600 -230 -30 /* GU,C */ - 200 -60 200 -350 200 /* GU,G */ - 460 -230 460 -230 160 /* GU,U */ - 310 310 -140 -150 140 /* UG,E */ - -480 -480 -630 -890 -630 /* UG,A */ - -180 -430 -510 -430 -180 /* UG,C */ - 310 310 -630 -150 -630 /* UG,G */ - 140 -430 -140 -430 140 /* UG,U */ - 600 -230 600 -230 200 /* AU,E */ - 200 -390 200 -350 200 /* AU,A */ - 600 -230 600 -230 -30 /* AU,C */ - 200 -310 200 -350 200 /* AU,G */ - 460 -230 460 -230 -170 /* AU,U */ - 140 -380 -140 -430 140 /* UA,E */ - -400 -400 -630 -890 -630 /* UA,A */ - -180 -430 -510 -430 -180 /* UA,C */ - -380 -380 -630 -890 -630 /* UA,G */ - 140 -430 -140 -430 140 /* UA,U */ - 600 310 600 -150 200 /* NS,E */ - 200 -340 200 -350 200 /* NS,A */ - 600 -230 600 -230 -30 /* NS,C */ - 310 310 200 -150 200 /* NS,G */ - 460 -230 460 -230 160 /* NS,U */ - -# mismatch_exterior - -80 -100 -110 -100 -80 /* CG,E */ - -140 -150 -150 -140 -150 /* CG,A */ - -80 -100 -110 -100 -80 /* CG,C */ - -140 -140 -150 -160 -150 /* CG,G */ - -100 -100 -140 -100 -120 /* CG,U */ - -50 -110 -70 -110 -50 /* GC,E */ - -110 -110 -150 -130 -150 /* GC,A */ - -50 -110 -70 -110 -50 /* GC,C */ - -140 -160 -150 -140 -150 /* GC,G */ - -70 -110 -100 -110 -70 /* GC,U */ - -30 -30 -70 -60 -60 /* GU,E */ - -30 -30 -100 -80 -100 /* GU,A */ - -60 -60 -70 -60 -70 /* GU,C */ - -60 -60 -100 -80 -100 /* GU,G */ - -60 -60 -80 -60 -60 /* GU,U */ - -50 -50 -60 -70 -50 /* UG,E */ - -80 -100 -80 -110 -80 /* UG,A */ - -50 -70 -60 -70 -50 /* UG,C */ - -50 -50 -80 -80 -80 /* UG,G */ - -50 -70 -60 -70 -50 /* UG,U */ - -60 -60 -70 -60 -70 /* AU,E */ - -80 -80 -100 -80 -100 /* AU,A */ - -60 -60 -70 -60 -70 /* AU,C */ - -80 -80 -100 -80 -100 /* AU,G */ - -60 -60 -80 -60 -80 /* AU,U */ - -50 -70 -60 -70 -50 /* UA,E */ - -80 -100 -80 -110 -80 /* UA,A */ - -50 -70 -60 -70 -50 /* UA,C */ - -80 -110 -80 -120 -80 /* UA,G */ - -50 -70 -60 -70 -50 /* UA,U */ - -30 -30 -60 -60 -50 /* NS,E */ - -30 -30 -80 -80 -80 /* NS,A */ - -50 -60 -60 -60 -50 /* NS,C */ - -50 -50 -80 -80 -80 /* NS,G */ - -50 -60 -60 -60 -50 /* NS,U */ - -# mismatch_exterior_enthalpies - -270 -570 -340 -560 -270 /* CG,E */ - -560 -910 -560 -560 -560 /* CG,A */ - -270 -570 -340 -570 -270 /* CG,C */ - -560 -820 -560 -920 -560 /* CG,G */ - -530 -570 -530 -570 -860 /* CG,U */ - 50 -520 50 -560 -400 /* GC,E */ - -400 -520 -400 -560 -400 /* GC,A */ - 50 -720 50 -720 -420 /* GC,C */ - -400 -710 -400 -620 -400 /* GC,G */ - -30 -720 -30 -720 -500 /* GC,U */ - 600 -60 600 -230 200 /* GU,E */ - 200 -340 200 -350 200 /* GU,A */ - 600 -230 600 -230 -30 /* GU,C */ - 200 -60 200 -350 200 /* GU,G */ - 460 -230 460 -230 160 /* GU,U */ - 310 310 -140 -150 140 /* UG,E */ - -480 -480 -630 -890 -630 /* UG,A */ - -180 -430 -510 -430 -180 /* UG,C */ - 310 310 -630 -150 -630 /* UG,G */ - 140 -430 -140 -430 140 /* UG,U */ - 600 -230 600 -230 200 /* AU,E */ - 200 -390 200 -350 200 /* AU,A */ - 600 -230 600 -230 -30 /* AU,C */ - 200 -310 200 -350 200 /* AU,G */ - 460 -230 460 -230 -170 /* AU,U */ - 140 -380 -140 -430 140 /* UA,E */ - -400 -400 -630 -890 -630 /* UA,A */ - -180 -430 -510 -430 -180 /* UA,C */ - -380 -380 -630 -890 -630 /* UA,G */ - 140 -430 -140 -430 140 /* UA,U */ - 600 310 600 -150 200 /* NS,E */ - 200 -340 200 -350 200 /* NS,A */ - 600 -230 600 -230 -30 /* NS,C */ - 310 310 200 -150 200 /* NS,G */ - 460 -230 460 -230 160 /* NS,U */ - -# dangle5 - 0 -20 -30 0 0 /* CG */ - -10 -50 -30 -20 -10 /* GC */ - -10 -30 -10 -20 -20 /* GU */ - -20 -30 -30 -40 -20 /* UG */ - -10 -30 -10 -20 -20 /* AU */ - -20 -30 -30 -40 -20 /* UA */ - 0 -20 -10 0 0 /* NS */ - -# dangle5_enthalpies - 70 -160 70 -460 -40 /* CG */ - 330 -240 330 80 -140 /* GC */ - 690 -50 690 60 60 /* GU */ - 310 160 220 70 310 /* UG */ - 690 -50 690 60 60 /* AU */ - 310 160 220 70 310 /* UA */ - 690 160 690 80 310 /* NS */ - -# dangle3 - -80 -170 -80 -170 -120 /* CG */ - -40 -110 -40 -130 -60 /* GC */ - -50 -80 -50 -80 -60 /* GU */ - -10 -70 -10 -70 -10 /* UG */ - -50 -80 -50 -80 -60 /* AU */ - -10 -70 -10 -70 -10 /* UA */ - -10 -70 -10 -70 -10 /* NS */ - -# dangle3_enthalpies - -410 -900 -410 -860 -750 /* CG */ - -280 -740 -280 -640 -360 /* GC */ - -90 -490 -90 -550 -230 /* GU */ - -70 -570 -70 -580 -220 /* UG */ - -90 -490 -90 -550 -230 /* AU */ - -70 -570 -70 -580 -220 /* UA */ - -70 -490 -70 -550 -220 /* NS */ - -# int11 - 90 90 50 50 50 /* CG,CG,E */ - 90 90 50 50 50 /* CG,CG,A */ - 50 50 50 50 50 /* CG,CG,C */ - 50 50 50 -140 50 /* CG,CG,G */ - 50 50 50 50 40 /* CG,CG,U */ - 90 90 50 50 60 /* CG,GC,E */ - 90 90 -40 50 50 /* CG,GC,A */ - 60 30 50 50 60 /* CG,GC,C */ - 50 -10 50 -220 50 /* CG,GC,G */ - 50 50 0 50 -10 /* CG,GC,U */ - 120 120 120 120 120 /* CG,GU,E */ - 120 60 50 120 120 /* CG,GU,A */ - 120 120 120 120 120 /* CG,GU,C */ - 120 -20 120 -140 120 /* CG,GU,G */ - 120 120 100 120 110 /* CG,GU,U */ - 220 220 170 120 120 /* CG,UG,E */ - 220 220 130 120 120 /* CG,UG,A */ - 170 120 170 120 120 /* CG,UG,C */ - 120 120 120 -140 120 /* CG,UG,G */ - 120 120 120 120 110 /* CG,UG,U */ - 120 120 120 120 120 /* CG,AU,E */ - 120 120 120 120 120 /* CG,AU,A */ - 120 120 120 120 120 /* CG,AU,C */ - 120 120 120 -140 120 /* CG,AU,G */ - 120 120 120 120 80 /* CG,AU,U */ - 120 120 120 120 120 /* CG,UA,E */ - 120 120 120 120 120 /* CG,UA,A */ - 120 120 120 120 120 /* CG,UA,C */ - 120 120 120 -140 120 /* CG,UA,G */ - 120 120 120 120 120 /* CG,UA,U */ - 220 220 170 120 120 /* CG,NS,E */ - 220 220 130 120 120 /* CG,NS,A */ - 170 120 170 120 120 /* CG,NS,C */ - 120 120 120 -140 120 /* CG,NS,G */ - 120 120 120 120 120 /* CG,NS,U */ - 90 90 60 50 50 /* GC,CG,E */ - 90 90 30 -10 50 /* GC,CG,A */ - 50 -40 50 50 0 /* GC,CG,C */ - 50 50 50 -220 50 /* GC,CG,G */ - 60 50 60 50 -10 /* GC,CG,U */ - 80 80 50 50 50 /* GC,GC,E */ - 80 80 50 50 50 /* GC,GC,A */ - 50 50 50 50 50 /* GC,GC,C */ - 50 50 50 -230 50 /* GC,GC,G */ - 50 50 50 50 -60 /* GC,GC,U */ - 190 190 120 150 150 /* GC,GU,E */ - 190 190 120 150 120 /* GC,GU,A */ - 120 120 120 120 120 /* GC,GU,C */ - 120 120 120 -140 120 /* GC,GU,G */ - 150 120 120 120 150 /* GC,GU,U */ - 160 160 120 120 120 /* GC,UG,E */ - 160 160 120 100 120 /* GC,UG,A */ - 120 120 120 120 120 /* GC,UG,C */ - 120 120 120 -140 120 /* GC,UG,G */ - 120 120 120 120 70 /* GC,UG,U */ - 120 120 120 120 120 /* GC,AU,E */ - 120 120 120 120 120 /* GC,AU,A */ - 120 120 120 120 120 /* GC,AU,C */ - 120 120 120 -140 120 /* GC,AU,G */ - 120 120 120 120 80 /* GC,AU,U */ - 120 120 120 120 120 /* GC,UA,E */ - 120 120 120 120 120 /* GC,UA,A */ - 120 120 120 120 120 /* GC,UA,C */ - 120 120 120 -140 120 /* GC,UA,G */ - 120 120 120 120 120 /* GC,UA,U */ - 190 190 120 150 150 /* GC,NS,E */ - 190 190 120 150 120 /* GC,NS,A */ - 120 120 120 120 120 /* GC,NS,C */ - 120 120 120 -140 120 /* GC,NS,G */ - 150 120 120 120 150 /* GC,NS,U */ - 120 120 120 120 120 /* GU,CG,E */ - 120 60 120 -20 120 /* GU,CG,A */ - 120 50 120 120 100 /* GU,CG,C */ - 120 120 120 -140 120 /* GU,CG,G */ - 120 120 120 120 110 /* GU,CG,U */ - 190 190 120 120 150 /* GU,GC,E */ - 190 190 120 120 120 /* GU,GC,A */ - 120 120 120 120 120 /* GU,GC,C */ - 150 150 120 -140 120 /* GU,GC,G */ - 150 120 120 120 150 /* GU,GC,U */ - 190 190 190 190 190 /* GU,GU,E */ - 190 190 190 190 190 /* GU,GU,A */ - 190 190 190 190 190 /* GU,GU,C */ - 190 190 190 -70 190 /* GU,GU,G */ - 190 190 190 190 120 /* GU,GU,U */ - 190 190 190 190 190 /* GU,UG,E */ - 190 190 190 190 190 /* GU,UG,A */ - 190 190 190 190 190 /* GU,UG,C */ - 190 190 190 -70 190 /* GU,UG,G */ - 190 190 190 190 160 /* GU,UG,U */ - 190 190 190 190 190 /* GU,AU,E */ - 190 190 190 190 190 /* GU,AU,A */ - 190 190 190 190 190 /* GU,AU,C */ - 190 190 190 -70 190 /* GU,AU,G */ - 190 190 190 190 120 /* GU,AU,U */ - 190 190 190 190 190 /* GU,UA,E */ - 190 190 190 190 190 /* GU,UA,A */ - 190 190 190 190 190 /* GU,UA,C */ - 190 190 190 -70 190 /* GU,UA,G */ - 190 190 190 190 160 /* GU,UA,U */ - 190 190 190 190 190 /* GU,NS,E */ - 190 190 190 190 190 /* GU,NS,A */ - 190 190 190 190 190 /* GU,NS,C */ - 190 190 190 -70 190 /* GU,NS,G */ - 190 190 190 190 160 /* GU,NS,U */ - 220 220 170 120 120 /* UG,CG,E */ - 220 220 120 120 120 /* UG,CG,A */ - 170 130 170 120 120 /* UG,CG,C */ - 120 120 120 -140 120 /* UG,CG,G */ - 120 120 120 120 110 /* UG,CG,U */ - 160 160 120 120 120 /* UG,GC,E */ - 160 160 120 120 120 /* UG,GC,A */ - 120 120 120 120 120 /* UG,GC,C */ - 120 100 120 -140 120 /* UG,GC,G */ - 120 120 120 120 70 /* UG,GC,U */ - 190 190 190 190 190 /* UG,GU,E */ - 190 190 190 190 190 /* UG,GU,A */ - 190 190 190 190 190 /* UG,GU,C */ - 190 190 190 -70 190 /* UG,GU,G */ - 190 190 190 190 160 /* UG,GU,U */ - 190 190 190 190 190 /* UG,UG,E */ - 190 190 190 190 190 /* UG,UG,A */ - 190 190 190 190 190 /* UG,UG,C */ - 190 190 190 -70 190 /* UG,UG,G */ - 190 190 190 190 190 /* UG,UG,U */ - 190 190 190 190 190 /* UG,AU,E */ - 190 190 190 190 190 /* UG,AU,A */ - 190 190 190 190 190 /* UG,AU,C */ - 190 190 190 -70 190 /* UG,AU,G */ - 190 190 190 190 160 /* UG,AU,U */ - 190 190 190 190 190 /* UG,UA,E */ - 190 190 190 190 190 /* UG,UA,A */ - 190 190 190 190 190 /* UG,UA,C */ - 190 190 190 -70 190 /* UG,UA,G */ - 190 190 190 190 190 /* UG,UA,U */ - 220 220 190 190 190 /* UG,NS,E */ - 220 220 190 190 190 /* UG,NS,A */ - 190 190 190 190 190 /* UG,NS,C */ - 190 190 190 -70 190 /* UG,NS,G */ - 190 190 190 190 190 /* UG,NS,U */ - 120 120 120 120 120 /* AU,CG,E */ - 120 120 120 120 120 /* AU,CG,A */ - 120 120 120 120 120 /* AU,CG,C */ - 120 120 120 -140 120 /* AU,CG,G */ - 120 120 120 120 80 /* AU,CG,U */ - 120 120 120 120 120 /* AU,GC,E */ - 120 120 120 120 120 /* AU,GC,A */ - 120 120 120 120 120 /* AU,GC,C */ - 120 120 120 -140 120 /* AU,GC,G */ - 120 120 120 120 80 /* AU,GC,U */ - 190 190 190 190 190 /* AU,GU,E */ - 190 190 190 190 190 /* AU,GU,A */ - 190 190 190 190 190 /* AU,GU,C */ - 190 190 190 -70 190 /* AU,GU,G */ - 190 190 190 190 120 /* AU,GU,U */ - 190 190 190 190 190 /* AU,UG,E */ - 190 190 190 190 190 /* AU,UG,A */ - 190 190 190 190 190 /* AU,UG,C */ - 190 190 190 -70 190 /* AU,UG,G */ - 190 190 190 190 160 /* AU,UG,U */ - 190 190 190 190 190 /* AU,AU,E */ - 190 190 190 190 190 /* AU,AU,A */ - 190 190 190 190 190 /* AU,AU,C */ - 190 190 190 -70 190 /* AU,AU,G */ - 190 190 190 190 120 /* AU,AU,U */ - 190 190 190 190 190 /* AU,UA,E */ - 190 190 190 190 190 /* AU,UA,A */ - 190 190 190 190 190 /* AU,UA,C */ - 190 190 190 -70 190 /* AU,UA,G */ - 190 190 190 190 150 /* AU,UA,U */ - 190 190 190 190 190 /* AU,NS,E */ - 190 190 190 190 190 /* AU,NS,A */ - 190 190 190 190 190 /* AU,NS,C */ - 190 190 190 -70 190 /* AU,NS,G */ - 190 190 190 190 160 /* AU,NS,U */ - 120 120 120 120 120 /* UA,CG,E */ - 120 120 120 120 120 /* UA,CG,A */ - 120 120 120 120 120 /* UA,CG,C */ - 120 120 120 -140 120 /* UA,CG,G */ - 120 120 120 120 120 /* UA,CG,U */ - 120 120 120 120 120 /* UA,GC,E */ - 120 120 120 120 120 /* UA,GC,A */ - 120 120 120 120 120 /* UA,GC,C */ - 120 120 120 -140 120 /* UA,GC,G */ - 120 120 120 120 120 /* UA,GC,U */ - 190 190 190 190 190 /* UA,GU,E */ - 190 190 190 190 190 /* UA,GU,A */ - 190 190 190 190 190 /* UA,GU,C */ - 190 190 190 -70 190 /* UA,GU,G */ - 190 190 190 190 160 /* UA,GU,U */ - 190 190 190 190 190 /* UA,UG,E */ - 190 190 190 190 190 /* UA,UG,A */ - 190 190 190 190 190 /* UA,UG,C */ - 190 190 190 -70 190 /* UA,UG,G */ - 190 190 190 190 190 /* UA,UG,U */ - 190 190 190 190 190 /* UA,AU,E */ - 190 190 190 190 190 /* UA,AU,A */ - 190 190 190 190 190 /* UA,AU,C */ - 190 190 190 -70 190 /* UA,AU,G */ - 190 190 190 190 150 /* UA,AU,U */ - 190 190 190 190 190 /* UA,UA,E */ - 190 190 190 190 190 /* UA,UA,A */ - 190 190 190 190 190 /* UA,UA,C */ - 190 190 190 -70 190 /* UA,UA,G */ - 190 190 190 190 170 /* UA,UA,U */ - 190 190 190 190 190 /* UA,NS,E */ - 190 190 190 190 190 /* UA,NS,A */ - 190 190 190 190 190 /* UA,NS,C */ - 190 190 190 -70 190 /* UA,NS,G */ - 190 190 190 190 190 /* UA,NS,U */ - 220 220 170 120 120 /* NS,CG,E */ - 220 220 120 120 120 /* NS,CG,A */ - 170 130 170 120 120 /* NS,CG,C */ - 120 120 120 -140 120 /* NS,CG,G */ - 120 120 120 120 120 /* NS,CG,U */ - 190 190 120 120 150 /* NS,GC,E */ - 190 190 120 120 120 /* NS,GC,A */ - 120 120 120 120 120 /* NS,GC,C */ - 150 150 120 -140 120 /* NS,GC,G */ - 150 120 120 120 150 /* NS,GC,U */ - 190 190 190 190 190 /* NS,GU,E */ - 190 190 190 190 190 /* NS,GU,A */ - 190 190 190 190 190 /* NS,GU,C */ - 190 190 190 -70 190 /* NS,GU,G */ - 190 190 190 190 160 /* NS,GU,U */ - 220 220 190 190 190 /* NS,UG,E */ - 220 220 190 190 190 /* NS,UG,A */ - 190 190 190 190 190 /* NS,UG,C */ - 190 190 190 -70 190 /* NS,UG,G */ - 190 190 190 190 190 /* NS,UG,U */ - 190 190 190 190 190 /* NS,AU,E */ - 190 190 190 190 190 /* NS,AU,A */ - 190 190 190 190 190 /* NS,AU,C */ - 190 190 190 -70 190 /* NS,AU,G */ - 190 190 190 190 160 /* NS,AU,U */ - 190 190 190 190 190 /* NS,UA,E */ - 190 190 190 190 190 /* NS,UA,A */ - 190 190 190 190 190 /* NS,UA,C */ - 190 190 190 -70 190 /* NS,UA,G */ - 190 190 190 190 190 /* NS,UA,U */ - 220 220 190 190 190 /* NS,NS,E */ - 220 220 190 190 190 /* NS,NS,A */ - 190 190 190 190 190 /* NS,NS,C */ - 190 190 190 -70 190 /* NS,NS,G */ - 190 190 190 190 190 /* NS,NS,U */ - -# int11_enthalpies - -1050 -1050 -1050 -1050 -1050 /* CG,CG,E */ - -1050 -1050 -1050 -1050 -1050 /* CG,CG,A */ - -1050 -1050 -1050 -1050 -1050 /* CG,CG,C */ - -1050 -1050 -1050 -1840 -1050 /* CG,CG,G */ - -1050 -1050 -1050 -1050 -1050 /* CG,CG,U */ - -1050 -1050 -1050 -1050 -1050 /* CG,GC,E */ - -1050 -1050 -1050 -1050 -1050 /* CG,GC,A */ - -1050 -1050 -1050 -1050 -1050 /* CG,GC,C */ - -1050 -1050 -1050 -1840 -1050 /* CG,GC,G */ - -1050 -1050 -1050 -1050 -1390 /* CG,GC,U */ - -550 -550 -550 -550 -550 /* CG,GU,E */ - -550 -550 -550 -550 -550 /* CG,GU,A */ - -550 -550 -550 -550 -550 /* CG,GU,C */ - -550 -550 -550 -1340 -550 /* CG,GU,G */ - -550 -550 -550 -550 -890 /* CG,GU,U */ - -550 -550 -550 -550 -550 /* CG,UG,E */ - -550 -550 -550 -550 -550 /* CG,UG,A */ - -550 -550 -550 -550 -550 /* CG,UG,C */ - -550 -550 -550 -1340 -550 /* CG,UG,G */ - -550 -550 -550 -550 -550 /* CG,UG,U */ - -550 -550 -550 -550 -550 /* CG,AU,E */ - -550 -550 -550 -550 -550 /* CG,AU,A */ - -550 -550 -550 -550 -550 /* CG,AU,C */ - -550 -550 -550 -1340 -550 /* CG,AU,G */ - -550 -550 -550 -550 -890 /* CG,AU,U */ - -550 -550 -550 -550 -550 /* CG,UA,E */ - -550 -550 -550 -550 -550 /* CG,UA,A */ - -550 -550 -550 -550 -550 /* CG,UA,C */ - -550 -550 -550 -1340 -550 /* CG,UA,G */ - -550 -550 -550 -550 -550 /* CG,UA,U */ - -550 -550 -550 -550 -550 /* CG,NS,E */ - -550 -550 -550 -550 -550 /* CG,NS,A */ - -550 -550 -550 -550 -550 /* CG,NS,C */ - -550 -550 -550 -1340 -550 /* CG,NS,G */ - -550 -550 -550 -550 -550 /* CG,NS,U */ - -1050 -1050 -1050 -1050 -1050 /* GC,CG,E */ - -1050 -1050 -1050 -1050 -1050 /* GC,CG,A */ - -1050 -1050 -1050 -1050 -1050 /* GC,CG,C */ - -1050 -1050 -1050 -1840 -1050 /* GC,CG,G */ - -1050 -1050 -1050 -1050 -1390 /* GC,CG,U */ - -1050 -1050 -1050 -1050 -1050 /* GC,GC,E */ - -1050 -1050 -1050 -1050 -1050 /* GC,GC,A */ - -1050 -1050 -1050 -1050 -1050 /* GC,GC,C */ - -1050 -1050 -1050 -1840 -1050 /* GC,GC,G */ - -1050 -1050 -1050 -1050 -1730 /* GC,GC,U */ - -550 -550 -550 -550 -550 /* GC,GU,E */ - -550 -550 -550 -550 -550 /* GC,GU,A */ - -550 -550 -550 -550 -550 /* GC,GU,C */ - -550 -550 -550 -1340 -550 /* GC,GU,G */ - -550 -550 -550 -550 -1230 /* GC,GU,U */ - -550 -550 -550 -550 -550 /* GC,UG,E */ - -550 -550 -550 -550 -550 /* GC,UG,A */ - -550 -550 -550 -550 -550 /* GC,UG,C */ - -550 -550 -550 -1340 -550 /* GC,UG,G */ - -550 -550 -550 -550 -890 /* GC,UG,U */ - -550 -550 -550 -550 -550 /* GC,AU,E */ - -550 -550 -550 -550 -550 /* GC,AU,A */ - -550 -550 -550 -550 -550 /* GC,AU,C */ - -550 -550 -550 -1340 -550 /* GC,AU,G */ - -550 -550 -550 -550 -1230 /* GC,AU,U */ - -550 -550 -550 -550 -550 /* GC,UA,E */ - -550 -550 -550 -550 -550 /* GC,UA,A */ - -550 -550 -550 -550 -550 /* GC,UA,C */ - -550 -550 -550 -1340 -550 /* GC,UA,G */ - -550 -550 -550 -550 -890 /* GC,UA,U */ - -550 -550 -550 -550 -550 /* GC,NS,E */ - -550 -550 -550 -550 -550 /* GC,NS,A */ - -550 -550 -550 -550 -550 /* GC,NS,C */ - -550 -550 -550 -1340 -550 /* GC,NS,G */ - -550 -550 -550 -550 -890 /* GC,NS,U */ - -550 -550 -550 -550 -550 /* GU,CG,E */ - -550 -550 -550 -550 -550 /* GU,CG,A */ - -550 -550 -550 -550 -550 /* GU,CG,C */ - -550 -550 -550 -1340 -550 /* GU,CG,G */ - -550 -550 -550 -550 -890 /* GU,CG,U */ - -550 -550 -550 -550 -550 /* GU,GC,E */ - -550 -550 -550 -550 -550 /* GU,GC,A */ - -550 -550 -550 -550 -550 /* GU,GC,C */ - -550 -550 -550 -1340 -550 /* GU,GC,G */ - -550 -550 -550 -550 -1230 /* GU,GC,U */ - -50 -50 -50 -50 -50 /* GU,GU,E */ - -50 -50 -50 -50 -50 /* GU,GU,A */ - -50 -50 -50 -50 -50 /* GU,GU,C */ - -50 -50 -50 -830 -50 /* GU,GU,G */ - -50 -50 -50 -50 -730 /* GU,GU,U */ - -50 -50 -50 -50 -50 /* GU,UG,E */ - -50 -50 -50 -50 -50 /* GU,UG,A */ - -50 -50 -50 -50 -50 /* GU,UG,C */ - -50 -50 -50 -830 -50 /* GU,UG,G */ - -50 -50 -50 -50 -390 /* GU,UG,U */ - -50 -50 -50 -50 -50 /* GU,AU,E */ - -50 -50 -50 -50 -50 /* GU,AU,A */ - -50 -50 -50 -50 -50 /* GU,AU,C */ - -50 -50 -50 -830 -50 /* GU,AU,G */ - -50 -50 -50 -50 -730 /* GU,AU,U */ - -50 -50 -50 -50 -50 /* GU,UA,E */ - -50 -50 -50 -50 -50 /* GU,UA,A */ - -50 -50 -50 -50 -50 /* GU,UA,C */ - -50 -50 -50 -830 -50 /* GU,UA,G */ - -50 -50 -50 -50 -390 /* GU,UA,U */ - -50 -50 -50 -50 -50 /* GU,NS,E */ - -50 -50 -50 -50 -50 /* GU,NS,A */ - -50 -50 -50 -50 -50 /* GU,NS,C */ - -50 -50 -50 -830 -50 /* GU,NS,G */ - -50 -50 -50 -50 -390 /* GU,NS,U */ - -550 -550 -550 -550 -550 /* UG,CG,E */ - -550 -550 -550 -550 -550 /* UG,CG,A */ - -550 -550 -550 -550 -550 /* UG,CG,C */ - -550 -550 -550 -1340 -550 /* UG,CG,G */ - -550 -550 -550 -550 -550 /* UG,CG,U */ - -550 -550 -550 -550 -550 /* UG,GC,E */ - -550 -550 -550 -550 -550 /* UG,GC,A */ - -550 -550 -550 -550 -550 /* UG,GC,C */ - -550 -550 -550 -1340 -550 /* UG,GC,G */ - -550 -550 -550 -550 -890 /* UG,GC,U */ - -50 -50 -50 -50 -50 /* UG,GU,E */ - -50 -50 -50 -50 -50 /* UG,GU,A */ - -50 -50 -50 -50 -50 /* UG,GU,C */ - -50 -50 -50 -830 -50 /* UG,GU,G */ - -50 -50 -50 -50 -390 /* UG,GU,U */ - -50 -50 -50 -50 -50 /* UG,UG,E */ - -50 -50 -50 -50 -50 /* UG,UG,A */ - -50 -50 -50 -50 -50 /* UG,UG,C */ - -50 -50 -50 -830 -50 /* UG,UG,G */ - -50 -50 -50 -50 -50 /* UG,UG,U */ - -50 -50 -50 -50 -50 /* UG,AU,E */ - -50 -50 -50 -50 -50 /* UG,AU,A */ - -50 -50 -50 -50 -50 /* UG,AU,C */ - -50 -50 -50 -830 -50 /* UG,AU,G */ - -50 -50 -50 -50 -390 /* UG,AU,U */ - -50 -50 -50 -50 -50 /* UG,UA,E */ - -50 -50 -50 -50 -50 /* UG,UA,A */ - -50 -50 -50 -50 -50 /* UG,UA,C */ - -50 -50 -50 -830 -50 /* UG,UA,G */ - -50 -50 -50 -50 -50 /* UG,UA,U */ - -50 -50 -50 -50 -50 /* UG,NS,E */ - -50 -50 -50 -50 -50 /* UG,NS,A */ - -50 -50 -50 -50 -50 /* UG,NS,C */ - -50 -50 -50 -830 -50 /* UG,NS,G */ - -50 -50 -50 -50 -50 /* UG,NS,U */ - -550 -550 -550 -550 -550 /* AU,CG,E */ - -550 -550 -550 -550 -550 /* AU,CG,A */ - -550 -550 -550 -550 -550 /* AU,CG,C */ - -550 -550 -550 -1340 -550 /* AU,CG,G */ - -550 -550 -550 -550 -890 /* AU,CG,U */ - -550 -550 -550 -550 -550 /* AU,GC,E */ - -550 -550 -550 -550 -550 /* AU,GC,A */ - -550 -550 -550 -550 -550 /* AU,GC,C */ - -550 -550 -550 -1340 -550 /* AU,GC,G */ - -550 -550 -550 -550 -1230 /* AU,GC,U */ - -50 -50 -50 -50 -50 /* AU,GU,E */ - -50 -50 -50 -50 -50 /* AU,GU,A */ - -50 -50 -50 -50 -50 /* AU,GU,C */ - -50 -50 -50 -830 -50 /* AU,GU,G */ - -50 -50 -50 -50 -730 /* AU,GU,U */ - -50 -50 -50 -50 -50 /* AU,UG,E */ - -50 -50 -50 -50 -50 /* AU,UG,A */ - -50 -50 -50 -50 -50 /* AU,UG,C */ - -50 -50 -50 -830 -50 /* AU,UG,G */ - -50 -50 -50 -50 -390 /* AU,UG,U */ - -50 -50 -50 -50 -50 /* AU,AU,E */ - -50 -50 -50 -50 -50 /* AU,AU,A */ - -50 -50 -50 -50 -50 /* AU,AU,C */ - -50 -50 -50 -830 -50 /* AU,AU,G */ - -50 -50 -50 -50 -730 /* AU,AU,U */ - -50 -50 -50 -50 -50 /* AU,UA,E */ - -50 -50 -50 -50 -50 /* AU,UA,A */ - -50 -50 -50 -50 -50 /* AU,UA,C */ - -50 -50 -50 -830 -50 /* AU,UA,G */ - -50 -50 -50 -50 -390 /* AU,UA,U */ - -50 -50 -50 -50 -50 /* AU,NS,E */ - -50 -50 -50 -50 -50 /* AU,NS,A */ - -50 -50 -50 -50 -50 /* AU,NS,C */ - -50 -50 -50 -830 -50 /* AU,NS,G */ - -50 -50 -50 -50 -390 /* AU,NS,U */ - -550 -550 -550 -550 -550 /* UA,CG,E */ - -550 -550 -550 -550 -550 /* UA,CG,A */ - -550 -550 -550 -550 -550 /* UA,CG,C */ - -550 -550 -550 -1340 -550 /* UA,CG,G */ - -550 -550 -550 -550 -550 /* UA,CG,U */ - -550 -550 -550 -550 -550 /* UA,GC,E */ - -550 -550 -550 -550 -550 /* UA,GC,A */ - -550 -550 -550 -550 -550 /* UA,GC,C */ - -550 -550 -550 -1340 -550 /* UA,GC,G */ - -550 -550 -550 -550 -890 /* UA,GC,U */ - -50 -50 -50 -50 -50 /* UA,GU,E */ - -50 -50 -50 -50 -50 /* UA,GU,A */ - -50 -50 -50 -50 -50 /* UA,GU,C */ - -50 -50 -50 -830 -50 /* UA,GU,G */ - -50 -50 -50 -50 -390 /* UA,GU,U */ - -50 -50 -50 -50 -50 /* UA,UG,E */ - -50 -50 -50 -50 -50 /* UA,UG,A */ - -50 -50 -50 -50 -50 /* UA,UG,C */ - -50 -50 -50 -830 -50 /* UA,UG,G */ - -50 -50 -50 -50 -50 /* UA,UG,U */ - -50 -50 -50 -50 -50 /* UA,AU,E */ - -50 -50 -50 -50 -50 /* UA,AU,A */ - -50 -50 -50 -50 -50 /* UA,AU,C */ - -50 -50 -50 -830 -50 /* UA,AU,G */ - -50 -50 -50 -50 -390 /* UA,AU,U */ - -50 -50 -50 -50 -50 /* UA,UA,E */ - -50 -50 -50 -50 -50 /* UA,UA,A */ - -50 -50 -50 -50 -50 /* UA,UA,C */ - -50 -50 -50 -830 -50 /* UA,UA,G */ - -50 -50 -50 -50 -50 /* UA,UA,U */ - -50 -50 -50 -50 -50 /* UA,NS,E */ - -50 -50 -50 -50 -50 /* UA,NS,A */ - -50 -50 -50 -50 -50 /* UA,NS,C */ - -50 -50 -50 -830 -50 /* UA,NS,G */ - -50 -50 -50 -50 -50 /* UA,NS,U */ - -550 -550 -550 -550 -550 /* NS,CG,E */ - -550 -550 -550 -550 -550 /* NS,CG,A */ - -550 -550 -550 -550 -550 /* NS,CG,C */ - -550 -550 -550 -1340 -550 /* NS,CG,G */ - -550 -550 -550 -550 -550 /* NS,CG,U */ - -550 -550 -550 -550 -550 /* NS,GC,E */ - -550 -550 -550 -550 -550 /* NS,GC,A */ - -550 -550 -550 -550 -550 /* NS,GC,C */ - -550 -550 -550 -1340 -550 /* NS,GC,G */ - -550 -550 -550 -550 -890 /* NS,GC,U */ - -50 -50 -50 -50 -50 /* NS,GU,E */ - -50 -50 -50 -50 -50 /* NS,GU,A */ - -50 -50 -50 -50 -50 /* NS,GU,C */ - -50 -50 -50 -830 -50 /* NS,GU,G */ - -50 -50 -50 -50 -390 /* NS,GU,U */ - -50 -50 -50 -50 -50 /* NS,UG,E */ - -50 -50 -50 -50 -50 /* NS,UG,A */ - -50 -50 -50 -50 -50 /* NS,UG,C */ - -50 -50 -50 -830 -50 /* NS,UG,G */ - -50 -50 -50 -50 -50 /* NS,UG,U */ - -50 -50 -50 -50 -50 /* NS,AU,E */ - -50 -50 -50 -50 -50 /* NS,AU,A */ - -50 -50 -50 -50 -50 /* NS,AU,C */ - -50 -50 -50 -830 -50 /* NS,AU,G */ - -50 -50 -50 -50 -390 /* NS,AU,U */ - -50 -50 -50 -50 -50 /* NS,UA,E */ - -50 -50 -50 -50 -50 /* NS,UA,A */ - -50 -50 -50 -50 -50 /* NS,UA,C */ - -50 -50 -50 -830 -50 /* NS,UA,G */ - -50 -50 -50 -50 -50 /* NS,UA,U */ - -50 -50 -50 -50 -50 /* NS,NS,E */ - -50 -50 -50 -50 -50 /* NS,NS,A */ - -50 -50 -50 -50 -50 /* NS,NS,C */ - -50 -50 -50 -830 -50 /* NS,NS,G */ - -50 -50 -50 -50 -50 /* NS,NS,U */ - -# int21 - 230 230 230 230 230 /* CG,CG,E,E */ - 230 230 230 230 230 /* CG,CG,E,A */ - 230 230 230 230 230 /* CG,CG,E,C */ - 230 230 230 230 230 /* CG,CG,E,G */ - 230 230 230 230 230 /* CG,CG,E,U */ - 230 230 230 110 230 /* CG,CG,A,E */ - 230 230 230 110 230 /* CG,CG,A,A */ - 230 230 230 110 230 /* CG,CG,A,C */ - 110 110 110 110 110 /* CG,CG,A,G */ - 230 230 230 110 230 /* CG,CG,A,U */ - 230 230 230 230 230 /* CG,CG,C,E */ - 230 230 230 230 230 /* CG,CG,C,A */ - 230 230 230 230 230 /* CG,CG,C,C */ - 230 230 230 230 230 /* CG,CG,C,G */ - 230 230 230 230 230 /* CG,CG,C,U */ - 230 110 230 110 230 /* CG,CG,G,E */ - 110 110 110 110 110 /* CG,CG,G,A */ - 230 110 230 110 230 /* CG,CG,G,C */ - 110 110 110 110 110 /* CG,CG,G,G */ - 230 110 230 110 230 /* CG,CG,G,U */ - 230 230 230 230 150 /* CG,CG,U,E */ - 230 230 230 230 150 /* CG,CG,U,A */ - 230 230 230 230 150 /* CG,CG,U,C */ - 230 230 230 230 150 /* CG,CG,U,G */ - 150 150 150 150 150 /* CG,CG,U,U */ - 250 250 250 230 230 /* CG,GC,E,E */ - 250 250 230 230 230 /* CG,GC,E,A */ - 250 230 250 230 230 /* CG,GC,E,C */ - 230 230 230 230 230 /* CG,GC,E,G */ - 250 250 230 230 230 /* CG,GC,E,U */ - 250 250 230 110 230 /* CG,GC,A,E */ - 250 250 230 110 230 /* CG,GC,A,A */ - 230 230 170 110 230 /* CG,GC,A,C */ - 110 80 110 110 110 /* CG,GC,A,G */ - 230 230 230 110 230 /* CG,GC,A,U */ - 250 250 250 230 230 /* CG,GC,C,E */ - 230 230 230 230 230 /* CG,GC,C,A */ - 250 230 250 230 230 /* CG,GC,C,C */ - 230 230 230 230 230 /* CG,GC,C,G */ - 250 250 230 230 230 /* CG,GC,C,U */ - 230 170 230 110 230 /* CG,GC,G,E */ - 230 170 230 80 230 /* CG,GC,G,A */ - 230 110 230 110 230 /* CG,GC,G,C */ - 120 120 110 110 110 /* CG,GC,G,G */ - 230 110 230 110 230 /* CG,GC,G,U */ - 230 230 230 230 150 /* CG,GC,U,E */ - 230 230 230 230 150 /* CG,GC,U,A */ - 230 230 220 230 150 /* CG,GC,U,C */ - 230 230 230 230 150 /* CG,GC,U,G */ - 170 150 170 150 140 /* CG,GC,U,U */ - 300 300 300 300 300 /* CG,GU,E,E */ - 300 300 300 300 300 /* CG,GU,E,A */ - 300 300 300 300 300 /* CG,GU,E,C */ - 300 300 300 300 300 /* CG,GU,E,G */ - 300 300 300 300 300 /* CG,GU,E,U */ - 300 300 300 190 300 /* CG,GU,A,E */ - 300 300 300 190 300 /* CG,GU,A,A */ - 300 300 300 190 300 /* CG,GU,A,C */ - 190 190 190 190 190 /* CG,GU,A,G */ - 300 300 300 190 300 /* CG,GU,A,U */ - 300 300 300 300 300 /* CG,GU,C,E */ - 300 300 300 300 300 /* CG,GU,C,A */ - 300 300 300 300 300 /* CG,GU,C,C */ - 300 300 300 300 300 /* CG,GU,C,G */ - 300 300 300 300 300 /* CG,GU,C,U */ - 300 190 300 190 300 /* CG,GU,G,E */ - 300 190 300 190 300 /* CG,GU,G,A */ - 300 190 300 190 300 /* CG,GU,G,C */ - 190 190 190 190 190 /* CG,GU,G,G */ - 300 190 300 190 300 /* CG,GU,G,U */ - 300 300 300 300 220 /* CG,GU,U,E */ - 300 300 300 300 220 /* CG,GU,U,A */ - 300 300 300 300 220 /* CG,GU,U,C */ - 300 300 300 300 220 /* CG,GU,U,G */ - 220 220 220 220 220 /* CG,GU,U,U */ - 300 300 300 300 300 /* CG,UG,E,E */ - 300 300 300 300 300 /* CG,UG,E,A */ - 300 300 300 300 300 /* CG,UG,E,C */ - 300 300 300 300 300 /* CG,UG,E,G */ - 300 300 300 300 300 /* CG,UG,E,U */ - 300 300 300 190 300 /* CG,UG,A,E */ - 300 300 300 190 300 /* CG,UG,A,A */ - 300 300 300 190 300 /* CG,UG,A,C */ - 190 190 190 190 190 /* CG,UG,A,G */ - 300 300 300 190 300 /* CG,UG,A,U */ - 300 300 300 300 300 /* CG,UG,C,E */ - 300 300 300 300 300 /* CG,UG,C,A */ - 300 300 300 300 300 /* CG,UG,C,C */ - 300 300 300 300 300 /* CG,UG,C,G */ - 300 300 300 300 300 /* CG,UG,C,U */ - 300 190 300 190 300 /* CG,UG,G,E */ - 190 190 190 190 190 /* CG,UG,G,A */ - 300 190 300 190 300 /* CG,UG,G,C */ - 190 190 190 190 190 /* CG,UG,G,G */ - 300 190 300 190 300 /* CG,UG,G,U */ - 300 300 300 300 220 /* CG,UG,U,E */ - 300 300 300 300 220 /* CG,UG,U,A */ - 300 300 300 300 220 /* CG,UG,U,C */ - 300 300 300 300 220 /* CG,UG,U,G */ - 220 220 220 220 220 /* CG,UG,U,U */ - 300 300 300 300 300 /* CG,AU,E,E */ - 300 300 300 300 300 /* CG,AU,E,A */ - 300 300 300 300 300 /* CG,AU,E,C */ - 300 300 300 300 300 /* CG,AU,E,G */ - 300 300 300 300 300 /* CG,AU,E,U */ - 300 300 300 190 300 /* CG,AU,A,E */ - 300 300 300 190 300 /* CG,AU,A,A */ - 300 300 300 190 300 /* CG,AU,A,C */ - 190 190 190 190 190 /* CG,AU,A,G */ - 300 300 300 190 300 /* CG,AU,A,U */ - 300 300 300 300 300 /* CG,AU,C,E */ - 300 300 300 300 300 /* CG,AU,C,A */ - 300 300 300 300 300 /* CG,AU,C,C */ - 300 300 300 300 300 /* CG,AU,C,G */ - 300 300 300 300 300 /* CG,AU,C,U */ - 300 190 300 190 300 /* CG,AU,G,E */ - 300 190 300 190 300 /* CG,AU,G,A */ - 300 190 300 190 300 /* CG,AU,G,C */ - 190 190 190 190 190 /* CG,AU,G,G */ - 300 190 300 190 300 /* CG,AU,G,U */ - 300 300 300 300 220 /* CG,AU,U,E */ - 300 300 300 300 220 /* CG,AU,U,A */ - 300 300 300 300 220 /* CG,AU,U,C */ - 300 300 300 300 220 /* CG,AU,U,G */ - 220 220 220 220 220 /* CG,AU,U,U */ - 300 300 300 300 300 /* CG,UA,E,E */ - 300 300 300 300 300 /* CG,UA,E,A */ - 300 300 300 300 300 /* CG,UA,E,C */ - 300 300 300 300 300 /* CG,UA,E,G */ - 300 300 300 300 300 /* CG,UA,E,U */ - 300 300 300 190 300 /* CG,UA,A,E */ - 300 300 300 190 300 /* CG,UA,A,A */ - 300 300 300 190 300 /* CG,UA,A,C */ - 190 190 190 190 190 /* CG,UA,A,G */ - 300 300 300 190 300 /* CG,UA,A,U */ - 300 300 300 300 300 /* CG,UA,C,E */ - 300 300 300 300 300 /* CG,UA,C,A */ - 300 300 300 300 300 /* CG,UA,C,C */ - 300 300 300 300 300 /* CG,UA,C,G */ - 300 300 300 300 300 /* CG,UA,C,U */ - 300 190 300 190 300 /* CG,UA,G,E */ - 190 190 190 190 190 /* CG,UA,G,A */ - 300 190 300 190 300 /* CG,UA,G,C */ - 190 190 190 190 190 /* CG,UA,G,G */ - 300 190 300 190 300 /* CG,UA,G,U */ - 300 300 300 300 220 /* CG,UA,U,E */ - 300 300 300 300 220 /* CG,UA,U,A */ - 300 300 300 300 220 /* CG,UA,U,C */ - 300 300 300 300 220 /* CG,UA,U,G */ - 220 220 220 220 220 /* CG,UA,U,U */ - 300 300 300 300 300 /* CG,NS,E,E */ - 300 300 300 300 300 /* CG,NS,E,A */ - 300 300 300 300 300 /* CG,NS,E,C */ - 300 300 300 300 300 /* CG,NS,E,G */ - 300 300 300 300 300 /* CG,NS,E,U */ - 300 300 300 190 300 /* CG,NS,A,E */ - 300 300 300 190 300 /* CG,NS,A,A */ - 300 300 300 190 300 /* CG,NS,A,C */ - 190 190 190 190 190 /* CG,NS,A,G */ - 300 300 300 190 300 /* CG,NS,A,U */ - 300 300 300 300 300 /* CG,NS,C,E */ - 300 300 300 300 300 /* CG,NS,C,A */ - 300 300 300 300 300 /* CG,NS,C,C */ - 300 300 300 300 300 /* CG,NS,C,G */ - 300 300 300 300 300 /* CG,NS,C,U */ - 300 190 300 190 300 /* CG,NS,G,E */ - 300 190 300 190 300 /* CG,NS,G,A */ - 300 190 300 190 300 /* CG,NS,G,C */ - 190 190 190 190 190 /* CG,NS,G,G */ - 300 190 300 190 300 /* CG,NS,G,U */ - 300 300 300 300 220 /* CG,NS,U,E */ - 300 300 300 300 220 /* CG,NS,U,A */ - 300 300 300 300 220 /* CG,NS,U,C */ - 300 300 300 300 220 /* CG,NS,U,G */ - 220 220 220 220 220 /* CG,NS,U,U */ - 250 250 230 230 230 /* GC,CG,E,E */ - 250 250 230 230 230 /* GC,CG,E,A */ - 230 230 230 230 230 /* GC,CG,E,C */ - 230 230 230 230 230 /* GC,CG,E,G */ - 230 230 230 230 230 /* GC,CG,E,U */ - 250 250 230 230 230 /* GC,CG,A,E */ - 250 250 230 210 230 /* GC,CG,A,A */ - 230 230 230 230 230 /* GC,CG,A,C */ - 120 120 110 110 110 /* GC,CG,A,G */ - 230 230 230 230 230 /* GC,CG,A,U */ - 230 230 230 230 230 /* GC,CG,C,E */ - 230 230 230 230 230 /* GC,CG,C,A */ - 230 230 230 230 230 /* GC,CG,C,C */ - 230 230 230 230 230 /* GC,CG,C,G */ - 230 230 190 230 230 /* GC,CG,C,U */ - 230 110 230 110 230 /* GC,CG,G,E */ - 110 110 110 110 110 /* GC,CG,G,A */ - 230 110 230 110 230 /* GC,CG,G,C */ - 110 110 110 110 110 /* GC,CG,G,G */ - 230 110 230 110 230 /* GC,CG,G,U */ - 230 230 230 230 150 /* GC,CG,U,E */ - 230 230 230 230 150 /* GC,CG,U,A */ - 230 230 230 230 150 /* GC,CG,U,C */ - 230 230 230 230 150 /* GC,CG,U,G */ - 150 150 150 150 150 /* GC,CG,U,U */ - 230 230 230 230 230 /* GC,GC,E,E */ - 230 230 230 230 230 /* GC,GC,E,A */ - 230 230 230 230 230 /* GC,GC,E,C */ - 230 230 230 230 230 /* GC,GC,E,G */ - 230 230 230 230 230 /* GC,GC,E,U */ - 230 230 230 230 230 /* GC,GC,A,E */ - 230 230 230 230 230 /* GC,GC,A,A */ - 230 230 230 230 230 /* GC,GC,A,C */ - 110 110 110 110 110 /* GC,GC,A,G */ - 230 230 230 230 230 /* GC,GC,A,U */ - 230 230 230 230 230 /* GC,GC,C,E */ - 230 230 230 230 230 /* GC,GC,C,A */ - 230 230 230 230 230 /* GC,GC,C,C */ - 230 230 230 230 230 /* GC,GC,C,G */ - 230 230 230 230 230 /* GC,GC,C,U */ - 230 110 230 110 230 /* GC,GC,G,E */ - 230 110 230 110 230 /* GC,GC,G,A */ - 230 110 230 110 230 /* GC,GC,G,C */ - 110 110 110 110 110 /* GC,GC,G,G */ - 230 110 230 110 230 /* GC,GC,G,U */ - 230 230 230 230 150 /* GC,GC,U,E */ - 230 230 230 230 150 /* GC,GC,U,A */ - 230 230 230 230 150 /* GC,GC,U,C */ - 230 230 230 230 150 /* GC,GC,U,G */ - 150 150 150 150 150 /* GC,GC,U,U */ - 300 300 300 300 300 /* GC,GU,E,E */ - 300 300 300 300 300 /* GC,GU,E,A */ - 300 300 300 300 300 /* GC,GU,E,C */ - 300 300 300 300 300 /* GC,GU,E,G */ - 300 300 300 300 300 /* GC,GU,E,U */ - 300 300 300 300 300 /* GC,GU,A,E */ - 300 300 300 300 300 /* GC,GU,A,A */ - 300 300 300 300 300 /* GC,GU,A,C */ - 190 190 190 190 190 /* GC,GU,A,G */ - 300 300 300 300 300 /* GC,GU,A,U */ - 300 300 300 300 300 /* GC,GU,C,E */ - 300 300 300 300 300 /* GC,GU,C,A */ - 300 300 300 300 300 /* GC,GU,C,C */ - 300 300 300 300 300 /* GC,GU,C,G */ - 300 300 300 300 300 /* GC,GU,C,U */ - 300 190 300 190 300 /* GC,GU,G,E */ - 300 190 300 190 300 /* GC,GU,G,A */ - 300 190 300 190 300 /* GC,GU,G,C */ - 190 190 190 190 190 /* GC,GU,G,G */ - 300 190 300 190 300 /* GC,GU,G,U */ - 300 300 300 300 220 /* GC,GU,U,E */ - 300 300 300 300 220 /* GC,GU,U,A */ - 300 300 300 300 220 /* GC,GU,U,C */ - 300 300 300 300 220 /* GC,GU,U,G */ - 220 220 220 220 220 /* GC,GU,U,U */ - 300 300 300 300 300 /* GC,UG,E,E */ - 300 300 300 300 300 /* GC,UG,E,A */ - 300 300 300 300 300 /* GC,UG,E,C */ - 300 300 300 300 300 /* GC,UG,E,G */ - 300 300 300 300 300 /* GC,UG,E,U */ - 300 300 300 300 300 /* GC,UG,A,E */ - 300 250 300 210 300 /* GC,UG,A,A */ - 300 300 300 300 300 /* GC,UG,A,C */ - 190 120 190 190 190 /* GC,UG,A,G */ - 300 300 300 300 300 /* GC,UG,A,U */ - 300 300 300 300 300 /* GC,UG,C,E */ - 300 300 300 300 300 /* GC,UG,C,A */ - 300 300 300 300 300 /* GC,UG,C,C */ - 300 300 300 300 300 /* GC,UG,C,G */ - 300 300 190 300 300 /* GC,UG,C,U */ - 300 190 300 190 300 /* GC,UG,G,E */ - 190 190 190 190 190 /* GC,UG,G,A */ - 300 190 300 190 300 /* GC,UG,G,C */ - 190 190 190 190 190 /* GC,UG,G,G */ - 300 190 300 190 300 /* GC,UG,G,U */ - 300 300 300 300 220 /* GC,UG,U,E */ - 300 300 300 300 220 /* GC,UG,U,A */ - 300 300 300 300 220 /* GC,UG,U,C */ - 300 300 300 300 220 /* GC,UG,U,G */ - 220 220 220 220 220 /* GC,UG,U,U */ - 300 300 300 300 300 /* GC,AU,E,E */ - 300 300 300 300 300 /* GC,AU,E,A */ - 300 300 300 300 300 /* GC,AU,E,C */ - 300 300 300 300 300 /* GC,AU,E,G */ - 300 300 300 300 300 /* GC,AU,E,U */ - 300 300 300 300 300 /* GC,AU,A,E */ - 300 300 300 300 300 /* GC,AU,A,A */ - 300 300 300 300 300 /* GC,AU,A,C */ - 190 190 190 190 190 /* GC,AU,A,G */ - 300 300 300 300 300 /* GC,AU,A,U */ - 300 300 300 300 300 /* GC,AU,C,E */ - 300 300 300 300 300 /* GC,AU,C,A */ - 300 300 300 300 300 /* GC,AU,C,C */ - 300 300 300 300 300 /* GC,AU,C,G */ - 300 300 300 300 300 /* GC,AU,C,U */ - 300 190 300 190 300 /* GC,AU,G,E */ - 300 190 300 190 300 /* GC,AU,G,A */ - 300 190 300 190 300 /* GC,AU,G,C */ - 190 190 190 190 190 /* GC,AU,G,G */ - 300 190 300 190 300 /* GC,AU,G,U */ - 300 300 300 300 220 /* GC,AU,U,E */ - 300 300 300 300 220 /* GC,AU,U,A */ - 300 300 300 300 220 /* GC,AU,U,C */ - 300 300 300 300 220 /* GC,AU,U,G */ - 220 220 220 220 220 /* GC,AU,U,U */ - 300 300 300 300 300 /* GC,UA,E,E */ - 300 300 300 300 300 /* GC,UA,E,A */ - 300 300 300 300 300 /* GC,UA,E,C */ - 300 300 300 300 300 /* GC,UA,E,G */ - 300 300 300 300 300 /* GC,UA,E,U */ - 300 300 300 300 300 /* GC,UA,A,E */ - 300 300 300 300 300 /* GC,UA,A,A */ - 300 300 300 300 300 /* GC,UA,A,C */ - 190 190 190 190 190 /* GC,UA,A,G */ - 300 300 300 300 300 /* GC,UA,A,U */ - 300 300 300 300 300 /* GC,UA,C,E */ - 300 300 300 300 300 /* GC,UA,C,A */ - 300 300 300 300 300 /* GC,UA,C,C */ - 300 300 300 300 300 /* GC,UA,C,G */ - 300 300 300 300 300 /* GC,UA,C,U */ - 300 190 300 190 300 /* GC,UA,G,E */ - 190 190 190 190 190 /* GC,UA,G,A */ - 300 190 300 190 300 /* GC,UA,G,C */ - 190 190 190 190 190 /* GC,UA,G,G */ - 300 190 300 190 300 /* GC,UA,G,U */ - 300 300 300 300 220 /* GC,UA,U,E */ - 300 300 300 300 220 /* GC,UA,U,A */ - 300 300 300 300 220 /* GC,UA,U,C */ - 300 300 300 300 220 /* GC,UA,U,G */ - 220 220 220 220 220 /* GC,UA,U,U */ - 300 300 300 300 300 /* GC,NS,E,E */ - 300 300 300 300 300 /* GC,NS,E,A */ - 300 300 300 300 300 /* GC,NS,E,C */ - 300 300 300 300 300 /* GC,NS,E,G */ - 300 300 300 300 300 /* GC,NS,E,U */ - 300 300 300 300 300 /* GC,NS,A,E */ - 300 300 300 300 300 /* GC,NS,A,A */ - 300 300 300 300 300 /* GC,NS,A,C */ - 190 190 190 190 190 /* GC,NS,A,G */ - 300 300 300 300 300 /* GC,NS,A,U */ - 300 300 300 300 300 /* GC,NS,C,E */ - 300 300 300 300 300 /* GC,NS,C,A */ - 300 300 300 300 300 /* GC,NS,C,C */ - 300 300 300 300 300 /* GC,NS,C,G */ - 300 300 300 300 300 /* GC,NS,C,U */ - 300 190 300 190 300 /* GC,NS,G,E */ - 300 190 300 190 300 /* GC,NS,G,A */ - 300 190 300 190 300 /* GC,NS,G,C */ - 190 190 190 190 190 /* GC,NS,G,G */ - 300 190 300 190 300 /* GC,NS,G,U */ - 300 300 300 300 220 /* GC,NS,U,E */ - 300 300 300 300 220 /* GC,NS,U,A */ - 300 300 300 300 220 /* GC,NS,U,C */ - 300 300 300 300 220 /* GC,NS,U,G */ - 220 220 220 220 220 /* GC,NS,U,U */ - 300 300 300 300 300 /* GU,CG,E,E */ - 300 300 300 300 300 /* GU,CG,E,A */ - 300 300 300 300 300 /* GU,CG,E,C */ - 300 300 300 300 300 /* GU,CG,E,G */ - 300 300 300 300 300 /* GU,CG,E,U */ - 300 300 300 300 300 /* GU,CG,A,E */ - 300 250 300 210 300 /* GU,CG,A,A */ - 300 300 300 300 300 /* GU,CG,A,C */ - 190 120 190 190 190 /* GU,CG,A,G */ - 300 300 300 300 300 /* GU,CG,A,U */ - 300 300 300 300 300 /* GU,CG,C,E */ - 300 300 300 300 300 /* GU,CG,C,A */ - 300 300 300 300 300 /* GU,CG,C,C */ - 300 300 300 300 300 /* GU,CG,C,G */ - 300 300 190 300 300 /* GU,CG,C,U */ - 300 190 300 190 300 /* GU,CG,G,E */ - 190 190 190 190 190 /* GU,CG,G,A */ - 300 190 300 190 300 /* GU,CG,G,C */ - 190 190 190 190 190 /* GU,CG,G,G */ - 300 190 300 190 300 /* GU,CG,G,U */ - 300 300 300 300 220 /* GU,CG,U,E */ - 300 300 300 300 220 /* GU,CG,U,A */ - 300 300 300 300 220 /* GU,CG,U,C */ - 300 300 300 300 220 /* GU,CG,U,G */ - 220 220 220 220 220 /* GU,CG,U,U */ - 300 300 300 300 300 /* GU,GC,E,E */ - 300 300 300 300 300 /* GU,GC,E,A */ - 300 300 300 300 300 /* GU,GC,E,C */ - 300 300 300 300 300 /* GU,GC,E,G */ - 300 300 300 300 300 /* GU,GC,E,U */ - 300 300 300 300 300 /* GU,GC,A,E */ - 300 300 300 300 300 /* GU,GC,A,A */ - 300 300 300 300 300 /* GU,GC,A,C */ - 190 190 190 190 190 /* GU,GC,A,G */ - 300 300 300 300 300 /* GU,GC,A,U */ - 300 300 300 300 300 /* GU,GC,C,E */ - 300 300 300 300 300 /* GU,GC,C,A */ - 300 300 300 300 300 /* GU,GC,C,C */ - 300 300 300 300 300 /* GU,GC,C,G */ - 300 300 300 300 300 /* GU,GC,C,U */ - 300 190 300 190 300 /* GU,GC,G,E */ - 300 190 300 190 300 /* GU,GC,G,A */ - 300 190 300 190 300 /* GU,GC,G,C */ - 190 190 190 190 190 /* GU,GC,G,G */ - 300 190 300 190 300 /* GU,GC,G,U */ - 300 300 300 300 220 /* GU,GC,U,E */ - 300 300 300 300 220 /* GU,GC,U,A */ - 300 300 300 300 220 /* GU,GC,U,C */ - 300 300 300 300 220 /* GU,GC,U,G */ - 220 220 220 220 220 /* GU,GC,U,U */ - 370 370 370 370 370 /* GU,GU,E,E */ - 370 370 370 370 370 /* GU,GU,E,A */ - 370 370 370 370 370 /* GU,GU,E,C */ - 370 370 370 370 370 /* GU,GU,E,G */ - 370 370 370 370 370 /* GU,GU,E,U */ - 370 370 370 370 370 /* GU,GU,A,E */ - 370 370 370 370 370 /* GU,GU,A,A */ - 370 370 370 370 370 /* GU,GU,A,C */ - 260 260 260 260 260 /* GU,GU,A,G */ - 370 370 370 370 370 /* GU,GU,A,U */ - 370 370 370 370 370 /* GU,GU,C,E */ - 370 370 370 370 370 /* GU,GU,C,A */ - 370 370 370 370 370 /* GU,GU,C,C */ - 370 370 370 370 370 /* GU,GU,C,G */ - 370 370 370 370 370 /* GU,GU,C,U */ - 370 260 370 260 370 /* GU,GU,G,E */ - 370 260 370 260 370 /* GU,GU,G,A */ - 370 260 370 260 370 /* GU,GU,G,C */ - 260 260 260 260 260 /* GU,GU,G,G */ - 370 260 370 260 370 /* GU,GU,G,U */ - 370 370 370 370 300 /* GU,GU,U,E */ - 370 370 370 370 300 /* GU,GU,U,A */ - 370 370 370 370 300 /* GU,GU,U,C */ - 370 370 370 370 300 /* GU,GU,U,G */ - 300 300 300 300 300 /* GU,GU,U,U */ - 370 370 370 370 370 /* GU,UG,E,E */ - 370 370 370 370 370 /* GU,UG,E,A */ - 370 370 370 370 370 /* GU,UG,E,C */ - 370 370 370 370 370 /* GU,UG,E,G */ - 370 370 370 370 370 /* GU,UG,E,U */ - 370 370 370 370 370 /* GU,UG,A,E */ - 370 250 370 210 370 /* GU,UG,A,A */ - 370 370 370 370 370 /* GU,UG,A,C */ - 260 120 260 260 260 /* GU,UG,A,G */ - 370 370 370 370 370 /* GU,UG,A,U */ - 370 370 370 370 370 /* GU,UG,C,E */ - 370 370 370 370 370 /* GU,UG,C,A */ - 370 370 370 370 370 /* GU,UG,C,C */ - 370 370 370 370 370 /* GU,UG,C,G */ - 370 370 190 370 370 /* GU,UG,C,U */ - 370 260 370 260 370 /* GU,UG,G,E */ - 260 260 260 260 260 /* GU,UG,G,A */ - 370 260 370 260 370 /* GU,UG,G,C */ - 260 260 260 260 260 /* GU,UG,G,G */ - 370 260 370 260 370 /* GU,UG,G,U */ - 370 370 370 370 300 /* GU,UG,U,E */ - 370 370 370 370 300 /* GU,UG,U,A */ - 370 370 370 370 300 /* GU,UG,U,C */ - 370 370 370 370 300 /* GU,UG,U,G */ - 300 300 300 300 300 /* GU,UG,U,U */ - 370 370 370 370 370 /* GU,AU,E,E */ - 370 370 370 370 370 /* GU,AU,E,A */ - 370 370 370 370 370 /* GU,AU,E,C */ - 370 370 370 370 370 /* GU,AU,E,G */ - 370 370 370 370 370 /* GU,AU,E,U */ - 370 370 370 370 370 /* GU,AU,A,E */ - 370 370 370 370 370 /* GU,AU,A,A */ - 370 370 370 370 370 /* GU,AU,A,C */ - 260 260 260 260 260 /* GU,AU,A,G */ - 370 370 370 370 370 /* GU,AU,A,U */ - 370 370 370 370 370 /* GU,AU,C,E */ - 370 370 370 370 370 /* GU,AU,C,A */ - 370 370 370 370 370 /* GU,AU,C,C */ - 370 370 370 370 370 /* GU,AU,C,G */ - 370 370 370 370 370 /* GU,AU,C,U */ - 370 260 370 260 370 /* GU,AU,G,E */ - 370 260 370 260 370 /* GU,AU,G,A */ - 370 260 370 260 370 /* GU,AU,G,C */ - 260 260 260 260 260 /* GU,AU,G,G */ - 370 260 370 260 370 /* GU,AU,G,U */ - 370 370 370 370 300 /* GU,AU,U,E */ - 370 370 370 370 300 /* GU,AU,U,A */ - 370 370 370 370 300 /* GU,AU,U,C */ - 370 370 370 370 300 /* GU,AU,U,G */ - 300 300 300 300 300 /* GU,AU,U,U */ - 370 370 370 370 370 /* GU,UA,E,E */ - 370 370 370 370 370 /* GU,UA,E,A */ - 370 370 370 370 370 /* GU,UA,E,C */ - 370 370 370 370 370 /* GU,UA,E,G */ - 370 370 370 370 370 /* GU,UA,E,U */ - 370 370 370 370 370 /* GU,UA,A,E */ - 370 370 370 370 370 /* GU,UA,A,A */ - 370 370 370 370 370 /* GU,UA,A,C */ - 260 260 260 260 260 /* GU,UA,A,G */ - 370 370 370 370 370 /* GU,UA,A,U */ - 370 370 370 370 370 /* GU,UA,C,E */ - 370 370 370 370 370 /* GU,UA,C,A */ - 370 370 370 370 370 /* GU,UA,C,C */ - 370 370 370 370 370 /* GU,UA,C,G */ - 370 370 370 370 370 /* GU,UA,C,U */ - 370 260 370 260 370 /* GU,UA,G,E */ - 260 260 260 260 260 /* GU,UA,G,A */ - 370 260 370 260 370 /* GU,UA,G,C */ - 260 260 260 260 260 /* GU,UA,G,G */ - 370 260 370 260 370 /* GU,UA,G,U */ - 370 370 370 370 300 /* GU,UA,U,E */ - 370 370 370 370 300 /* GU,UA,U,A */ - 370 370 370 370 300 /* GU,UA,U,C */ - 370 370 370 370 300 /* GU,UA,U,G */ - 300 300 300 300 300 /* GU,UA,U,U */ - 370 370 370 370 370 /* GU,NS,E,E */ - 370 370 370 370 370 /* GU,NS,E,A */ - 370 370 370 370 370 /* GU,NS,E,C */ - 370 370 370 370 370 /* GU,NS,E,G */ - 370 370 370 370 370 /* GU,NS,E,U */ - 370 370 370 370 370 /* GU,NS,A,E */ - 370 370 370 370 370 /* GU,NS,A,A */ - 370 370 370 370 370 /* GU,NS,A,C */ - 260 260 260 260 260 /* GU,NS,A,G */ - 370 370 370 370 370 /* GU,NS,A,U */ - 370 370 370 370 370 /* GU,NS,C,E */ - 370 370 370 370 370 /* GU,NS,C,A */ - 370 370 370 370 370 /* GU,NS,C,C */ - 370 370 370 370 370 /* GU,NS,C,G */ - 370 370 370 370 370 /* GU,NS,C,U */ - 370 260 370 260 370 /* GU,NS,G,E */ - 370 260 370 260 370 /* GU,NS,G,A */ - 370 260 370 260 370 /* GU,NS,G,C */ - 260 260 260 260 260 /* GU,NS,G,G */ - 370 260 370 260 370 /* GU,NS,G,U */ - 370 370 370 370 300 /* GU,NS,U,E */ - 370 370 370 370 300 /* GU,NS,U,A */ - 370 370 370 370 300 /* GU,NS,U,C */ - 370 370 370 370 300 /* GU,NS,U,G */ - 300 300 300 300 300 /* GU,NS,U,U */ - 300 300 300 300 300 /* UG,CG,E,E */ - 300 300 300 300 300 /* UG,CG,E,A */ - 300 300 300 300 300 /* UG,CG,E,C */ - 300 300 300 300 300 /* UG,CG,E,G */ - 300 300 300 300 300 /* UG,CG,E,U */ - 300 300 300 190 300 /* UG,CG,A,E */ - 300 300 300 190 300 /* UG,CG,A,A */ - 300 300 300 190 300 /* UG,CG,A,C */ - 190 190 190 190 190 /* UG,CG,A,G */ - 300 300 300 190 300 /* UG,CG,A,U */ - 300 300 300 300 300 /* UG,CG,C,E */ - 300 300 300 300 300 /* UG,CG,C,A */ - 300 300 300 300 300 /* UG,CG,C,C */ - 300 300 300 300 300 /* UG,CG,C,G */ - 300 300 300 300 300 /* UG,CG,C,U */ - 300 190 300 190 300 /* UG,CG,G,E */ - 190 190 190 190 190 /* UG,CG,G,A */ - 300 190 300 190 300 /* UG,CG,G,C */ - 190 190 190 190 190 /* UG,CG,G,G */ - 300 190 300 190 300 /* UG,CG,G,U */ - 300 300 300 300 220 /* UG,CG,U,E */ - 300 300 300 300 220 /* UG,CG,U,A */ - 300 300 300 300 220 /* UG,CG,U,C */ - 300 300 300 300 220 /* UG,CG,U,G */ - 220 220 220 220 220 /* UG,CG,U,U */ - 300 300 300 300 300 /* UG,GC,E,E */ - 300 300 300 300 300 /* UG,GC,E,A */ - 300 300 300 300 300 /* UG,GC,E,C */ - 300 300 300 300 300 /* UG,GC,E,G */ - 300 300 300 300 300 /* UG,GC,E,U */ - 300 300 300 190 300 /* UG,GC,A,E */ - 300 300 300 190 300 /* UG,GC,A,A */ - 300 300 300 190 300 /* UG,GC,A,C */ - 190 190 190 190 190 /* UG,GC,A,G */ - 300 300 300 190 300 /* UG,GC,A,U */ - 300 300 300 300 300 /* UG,GC,C,E */ - 300 300 300 300 300 /* UG,GC,C,A */ - 300 300 300 300 300 /* UG,GC,C,C */ - 300 300 300 300 300 /* UG,GC,C,G */ - 300 300 300 300 300 /* UG,GC,C,U */ - 300 190 300 190 300 /* UG,GC,G,E */ - 300 190 300 190 300 /* UG,GC,G,A */ - 300 190 300 190 300 /* UG,GC,G,C */ - 190 190 190 190 190 /* UG,GC,G,G */ - 300 190 300 190 300 /* UG,GC,G,U */ - 300 300 300 300 220 /* UG,GC,U,E */ - 300 300 300 300 220 /* UG,GC,U,A */ - 300 300 300 300 220 /* UG,GC,U,C */ - 300 300 300 300 220 /* UG,GC,U,G */ - 220 220 220 220 220 /* UG,GC,U,U */ - 370 370 370 370 370 /* UG,GU,E,E */ - 370 370 370 370 370 /* UG,GU,E,A */ - 370 370 370 370 370 /* UG,GU,E,C */ - 370 370 370 370 370 /* UG,GU,E,G */ - 370 370 370 370 370 /* UG,GU,E,U */ - 370 370 370 260 370 /* UG,GU,A,E */ - 370 370 370 260 370 /* UG,GU,A,A */ - 370 370 370 260 370 /* UG,GU,A,C */ - 260 260 260 260 260 /* UG,GU,A,G */ - 370 370 370 260 370 /* UG,GU,A,U */ - 370 370 370 370 370 /* UG,GU,C,E */ - 370 370 370 370 370 /* UG,GU,C,A */ - 370 370 370 370 370 /* UG,GU,C,C */ - 370 370 370 370 370 /* UG,GU,C,G */ - 370 370 370 370 370 /* UG,GU,C,U */ - 370 260 370 260 370 /* UG,GU,G,E */ - 370 260 370 260 370 /* UG,GU,G,A */ - 370 260 370 260 370 /* UG,GU,G,C */ - 260 260 260 260 260 /* UG,GU,G,G */ - 370 260 370 260 370 /* UG,GU,G,U */ - 370 370 370 370 300 /* UG,GU,U,E */ - 370 370 370 370 300 /* UG,GU,U,A */ - 370 370 370 370 300 /* UG,GU,U,C */ - 370 370 370 370 300 /* UG,GU,U,G */ - 300 300 300 300 300 /* UG,GU,U,U */ - 370 370 370 370 370 /* UG,UG,E,E */ - 370 370 370 370 370 /* UG,UG,E,A */ - 370 370 370 370 370 /* UG,UG,E,C */ - 370 370 370 370 370 /* UG,UG,E,G */ - 370 370 370 370 370 /* UG,UG,E,U */ - 370 370 370 260 370 /* UG,UG,A,E */ - 370 370 370 260 370 /* UG,UG,A,A */ - 370 370 370 260 370 /* UG,UG,A,C */ - 260 260 260 260 260 /* UG,UG,A,G */ - 370 370 370 260 370 /* UG,UG,A,U */ - 370 370 370 370 370 /* UG,UG,C,E */ - 370 370 370 370 370 /* UG,UG,C,A */ - 370 370 370 370 370 /* UG,UG,C,C */ - 370 370 370 370 370 /* UG,UG,C,G */ - 370 370 370 370 370 /* UG,UG,C,U */ - 370 260 370 260 370 /* UG,UG,G,E */ - 260 260 260 260 260 /* UG,UG,G,A */ - 370 260 370 260 370 /* UG,UG,G,C */ - 260 260 260 260 260 /* UG,UG,G,G */ - 370 260 370 260 370 /* UG,UG,G,U */ - 370 370 370 370 300 /* UG,UG,U,E */ - 370 370 370 370 300 /* UG,UG,U,A */ - 370 370 370 370 300 /* UG,UG,U,C */ - 370 370 370 370 300 /* UG,UG,U,G */ - 300 300 300 300 300 /* UG,UG,U,U */ - 370 370 370 370 370 /* UG,AU,E,E */ - 370 370 370 370 370 /* UG,AU,E,A */ - 370 370 370 370 370 /* UG,AU,E,C */ - 370 370 370 370 370 /* UG,AU,E,G */ - 370 370 370 370 370 /* UG,AU,E,U */ - 370 370 370 260 370 /* UG,AU,A,E */ - 370 370 370 260 370 /* UG,AU,A,A */ - 370 370 370 260 370 /* UG,AU,A,C */ - 260 260 260 260 260 /* UG,AU,A,G */ - 370 370 370 260 370 /* UG,AU,A,U */ - 370 370 370 370 370 /* UG,AU,C,E */ - 370 370 370 370 370 /* UG,AU,C,A */ - 370 370 370 370 370 /* UG,AU,C,C */ - 370 370 370 370 370 /* UG,AU,C,G */ - 370 370 370 370 370 /* UG,AU,C,U */ - 370 260 370 260 370 /* UG,AU,G,E */ - 370 260 370 260 370 /* UG,AU,G,A */ - 370 260 370 260 370 /* UG,AU,G,C */ - 260 260 260 260 260 /* UG,AU,G,G */ - 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370 370 370 370 370 /* AU,AU,A,A */ - 370 370 370 370 370 /* AU,AU,A,C */ - 260 260 260 260 260 /* AU,AU,A,G */ - 370 370 370 370 370 /* AU,AU,A,U */ - 370 370 370 370 370 /* AU,AU,C,E */ - 370 370 370 370 370 /* AU,AU,C,A */ - 370 370 370 370 370 /* AU,AU,C,C */ - 370 370 370 370 370 /* AU,AU,C,G */ - 370 370 370 370 370 /* AU,AU,C,U */ - 370 260 370 260 370 /* AU,AU,G,E */ - 370 260 370 260 370 /* AU,AU,G,A */ - 370 260 370 260 370 /* AU,AU,G,C */ - 260 260 260 260 260 /* AU,AU,G,G */ - 370 260 370 260 370 /* AU,AU,G,U */ - 370 370 370 370 300 /* AU,AU,U,E */ - 370 370 370 370 300 /* AU,AU,U,A */ - 370 370 370 370 300 /* AU,AU,U,C */ - 370 370 370 370 300 /* AU,AU,U,G */ - 300 300 300 300 300 /* AU,AU,U,U */ - 370 370 370 370 370 /* AU,UA,E,E */ - 370 370 370 370 370 /* AU,UA,E,A */ - 370 370 370 370 370 /* AU,UA,E,C */ - 370 370 370 370 370 /* AU,UA,E,G */ - 370 370 370 370 370 /* AU,UA,E,U */ - 370 370 370 370 370 /* AU,UA,A,E */ - 370 370 370 370 370 /* AU,UA,A,A */ - 370 370 370 370 370 /* AU,UA,A,C */ - 260 260 260 260 260 /* AU,UA,A,G */ - 370 370 370 370 370 /* AU,UA,A,U */ - 370 370 370 370 370 /* AU,UA,C,E */ - 370 370 370 370 370 /* AU,UA,C,A */ - 370 370 370 370 370 /* AU,UA,C,C */ - 370 370 370 370 370 /* AU,UA,C,G */ - 370 370 370 370 370 /* AU,UA,C,U */ - 370 260 370 260 370 /* AU,UA,G,E */ - 260 260 260 260 260 /* AU,UA,G,A */ - 370 260 370 260 370 /* AU,UA,G,C */ - 260 260 260 260 260 /* AU,UA,G,G */ - 370 260 370 260 370 /* AU,UA,G,U */ - 370 370 370 370 300 /* AU,UA,U,E */ - 370 370 370 370 300 /* AU,UA,U,A */ - 370 370 370 370 300 /* AU,UA,U,C */ - 370 370 370 370 300 /* AU,UA,U,G */ - 300 300 300 300 300 /* AU,UA,U,U */ - 370 370 370 370 370 /* AU,NS,E,E */ - 370 370 370 370 370 /* AU,NS,E,A */ - 370 370 370 370 370 /* AU,NS,E,C */ - 370 370 370 370 370 /* AU,NS,E,G */ - 370 370 370 370 370 /* AU,NS,E,U */ - 370 370 370 370 370 /* AU,NS,A,E */ - 370 370 370 370 370 /* AU,NS,A,A */ - 370 370 370 370 370 /* AU,NS,A,C */ - 260 260 260 260 260 /* AU,NS,A,G */ - 370 370 370 370 370 /* AU,NS,A,U */ - 370 370 370 370 370 /* AU,NS,C,E */ - 370 370 370 370 370 /* AU,NS,C,A */ - 370 370 370 370 370 /* AU,NS,C,C */ - 370 370 370 370 370 /* AU,NS,C,G */ - 370 370 370 370 370 /* AU,NS,C,U */ - 370 260 370 260 370 /* AU,NS,G,E */ - 370 260 370 260 370 /* AU,NS,G,A */ - 370 260 370 260 370 /* AU,NS,G,C */ - 260 260 260 260 260 /* AU,NS,G,G */ - 370 260 370 260 370 /* AU,NS,G,U */ - 370 370 370 370 300 /* AU,NS,U,E */ - 370 370 370 370 300 /* AU,NS,U,A */ - 370 370 370 370 300 /* AU,NS,U,C */ - 370 370 370 370 300 /* AU,NS,U,G */ - 300 300 300 300 300 /* AU,NS,U,U */ - 300 300 300 300 300 /* UA,CG,E,E */ - 300 300 300 300 300 /* UA,CG,E,A */ - 300 300 300 300 300 /* UA,CG,E,C */ - 300 300 300 300 300 /* UA,CG,E,G */ - 300 300 300 300 300 /* UA,CG,E,U */ - 300 300 300 190 300 /* UA,CG,A,E */ - 300 300 300 190 300 /* UA,CG,A,A */ - 300 300 300 190 300 /* UA,CG,A,C */ - 190 190 190 190 190 /* UA,CG,A,G */ - 300 300 300 190 300 /* UA,CG,A,U */ - 300 300 300 300 300 /* UA,CG,C,E */ - 300 300 300 300 300 /* UA,CG,C,A */ - 300 300 300 300 300 /* UA,CG,C,C */ - 300 300 300 300 300 /* UA,CG,C,G */ - 300 300 300 300 300 /* UA,CG,C,U */ - 300 190 300 190 300 /* UA,CG,G,E */ - 190 190 190 190 190 /* UA,CG,G,A */ - 300 190 300 190 300 /* UA,CG,G,C */ - 190 190 190 190 190 /* UA,CG,G,G */ - 300 190 300 190 300 /* UA,CG,G,U */ - 300 300 300 300 220 /* UA,CG,U,E */ - 300 300 300 300 220 /* UA,CG,U,A */ - 300 300 300 300 220 /* UA,CG,U,C */ - 300 300 300 300 220 /* UA,CG,U,G */ - 220 220 220 220 220 /* UA,CG,U,U */ - 300 300 300 300 300 /* UA,GC,E,E */ - 300 300 300 300 300 /* UA,GC,E,A */ - 300 300 300 300 300 /* UA,GC,E,C */ - 300 300 300 300 300 /* UA,GC,E,G */ - 300 300 300 300 300 /* UA,GC,E,U */ - 300 300 300 190 300 /* UA,GC,A,E */ - 300 300 300 190 300 /* UA,GC,A,A */ - 300 300 300 190 300 /* UA,GC,A,C */ - 190 190 190 190 190 /* UA,GC,A,G */ - 300 300 300 190 300 /* UA,GC,A,U */ - 300 300 300 300 300 /* UA,GC,C,E */ - 300 300 300 300 300 /* UA,GC,C,A */ - 300 300 300 300 300 /* UA,GC,C,C */ - 300 300 300 300 300 /* UA,GC,C,G */ - 300 300 300 300 300 /* UA,GC,C,U */ - 300 190 300 190 300 /* UA,GC,G,E */ - 300 190 300 190 300 /* UA,GC,G,A */ - 300 190 300 190 300 /* UA,GC,G,C */ - 190 190 190 190 190 /* UA,GC,G,G */ - 300 190 300 190 300 /* UA,GC,G,U */ - 300 300 300 300 220 /* UA,GC,U,E */ - 300 300 300 300 220 /* UA,GC,U,A */ - 300 300 300 300 220 /* UA,GC,U,C */ - 300 300 300 300 220 /* UA,GC,U,G */ - 220 220 220 220 220 /* UA,GC,U,U */ - 370 370 370 370 370 /* UA,GU,E,E */ - 370 370 370 370 370 /* UA,GU,E,A */ - 370 370 370 370 370 /* UA,GU,E,C */ - 370 370 370 370 370 /* UA,GU,E,G */ - 370 370 370 370 370 /* UA,GU,E,U */ - 370 370 370 260 370 /* UA,GU,A,E */ - 370 370 370 260 370 /* UA,GU,A,A */ - 370 370 370 260 370 /* UA,GU,A,C */ - 260 260 260 260 260 /* UA,GU,A,G */ - 370 370 370 260 370 /* UA,GU,A,U */ - 370 370 370 370 370 /* UA,GU,C,E */ - 370 370 370 370 370 /* UA,GU,C,A */ - 370 370 370 370 370 /* UA,GU,C,C */ - 370 370 370 370 370 /* UA,GU,C,G */ - 370 370 370 370 370 /* UA,GU,C,U */ - 370 260 370 260 370 /* UA,GU,G,E */ - 370 260 370 260 370 /* UA,GU,G,A */ - 370 260 370 260 370 /* UA,GU,G,C */ - 260 260 260 260 260 /* UA,GU,G,G */ - 370 260 370 260 370 /* UA,GU,G,U */ - 370 370 370 370 300 /* UA,GU,U,E */ - 370 370 370 370 300 /* UA,GU,U,A */ - 370 370 370 370 300 /* UA,GU,U,C */ - 370 370 370 370 300 /* UA,GU,U,G */ - 300 300 300 300 300 /* UA,GU,U,U */ - 370 370 370 370 370 /* UA,UG,E,E */ - 370 370 370 370 370 /* UA,UG,E,A */ - 370 370 370 370 370 /* UA,UG,E,C */ - 370 370 370 370 370 /* UA,UG,E,G */ - 370 370 370 370 370 /* UA,UG,E,U */ - 370 370 370 260 370 /* UA,UG,A,E */ - 370 370 370 260 370 /* UA,UG,A,A */ - 370 370 370 260 370 /* UA,UG,A,C */ - 260 260 260 260 260 /* UA,UG,A,G */ - 370 370 370 260 370 /* UA,UG,A,U */ - 370 370 370 370 370 /* UA,UG,C,E */ - 370 370 370 370 370 /* UA,UG,C,A */ - 370 370 370 370 370 /* UA,UG,C,C */ - 370 370 370 370 370 /* UA,UG,C,G */ - 370 370 370 370 370 /* UA,UG,C,U */ - 370 260 370 260 370 /* UA,UG,G,E */ - 260 260 260 260 260 /* UA,UG,G,A */ - 370 260 370 260 370 /* UA,UG,G,C */ - 260 260 260 260 260 /* UA,UG,G,G */ - 370 260 370 260 370 /* UA,UG,G,U */ - 370 370 370 370 300 /* UA,UG,U,E */ - 370 370 370 370 300 /* UA,UG,U,A */ - 370 370 370 370 300 /* UA,UG,U,C */ - 370 370 370 370 300 /* UA,UG,U,G */ - 300 300 300 300 300 /* UA,UG,U,U */ - 370 370 370 370 370 /* UA,AU,E,E */ - 370 370 370 370 370 /* UA,AU,E,A */ - 370 370 370 370 370 /* UA,AU,E,C */ - 370 370 370 370 370 /* UA,AU,E,G */ - 370 370 370 370 370 /* UA,AU,E,U */ - 370 370 370 260 370 /* UA,AU,A,E */ - 370 370 370 260 370 /* UA,AU,A,A */ - 370 370 370 260 370 /* UA,AU,A,C */ - 260 260 260 260 260 /* UA,AU,A,G */ - 370 370 370 260 370 /* UA,AU,A,U */ - 370 370 370 370 370 /* UA,AU,C,E */ - 370 370 370 370 370 /* UA,AU,C,A */ - 370 370 370 370 370 /* UA,AU,C,C */ - 370 370 370 370 370 /* UA,AU,C,G */ - 370 370 370 370 370 /* UA,AU,C,U */ - 370 260 370 260 370 /* UA,AU,G,E */ - 370 260 370 260 370 /* UA,AU,G,A */ - 370 260 370 260 370 /* UA,AU,G,C */ - 260 260 260 260 260 /* UA,AU,G,G */ - 370 260 370 260 370 /* UA,AU,G,U */ - 370 370 370 370 300 /* UA,AU,U,E */ - 370 370 370 370 300 /* UA,AU,U,A */ - 370 370 370 370 300 /* UA,AU,U,C */ - 370 370 370 370 300 /* UA,AU,U,G */ - 300 300 300 300 300 /* UA,AU,U,U */ - 370 370 370 370 370 /* UA,UA,E,E */ - 370 370 370 370 370 /* UA,UA,E,A */ - 370 370 370 370 370 /* UA,UA,E,C */ - 370 370 370 370 370 /* UA,UA,E,G */ - 370 370 370 370 370 /* UA,UA,E,U */ - 370 370 370 260 370 /* UA,UA,A,E */ - 370 370 370 260 370 /* UA,UA,A,A */ - 370 370 370 260 370 /* UA,UA,A,C */ - 260 260 260 260 260 /* UA,UA,A,G */ - 370 370 370 260 370 /* UA,UA,A,U */ - 370 370 370 370 370 /* UA,UA,C,E */ - 370 370 370 370 370 /* UA,UA,C,A */ - 370 370 370 370 370 /* UA,UA,C,C */ - 370 370 370 370 370 /* UA,UA,C,G */ - 370 370 370 370 370 /* UA,UA,C,U */ - 370 260 370 260 370 /* UA,UA,G,E */ - 260 260 260 260 260 /* UA,UA,G,A */ - 370 260 370 260 370 /* UA,UA,G,C */ - 260 260 260 260 260 /* UA,UA,G,G */ - 370 260 370 260 370 /* UA,UA,G,U */ - 370 370 370 370 300 /* UA,UA,U,E */ - 370 370 370 370 300 /* UA,UA,U,A */ - 370 370 370 370 300 /* UA,UA,U,C */ - 370 370 370 370 300 /* UA,UA,U,G */ - 300 300 300 300 300 /* UA,UA,U,U */ - 370 370 370 370 370 /* UA,NS,E,E */ - 370 370 370 370 370 /* UA,NS,E,A */ - 370 370 370 370 370 /* UA,NS,E,C */ - 370 370 370 370 370 /* UA,NS,E,G */ - 370 370 370 370 370 /* UA,NS,E,U */ - 370 370 370 260 370 /* UA,NS,A,E */ - 370 370 370 260 370 /* UA,NS,A,A */ - 370 370 370 260 370 /* UA,NS,A,C */ - 260 260 260 260 260 /* UA,NS,A,G */ - 370 370 370 260 370 /* UA,NS,A,U */ - 370 370 370 370 370 /* UA,NS,C,E */ - 370 370 370 370 370 /* UA,NS,C,A */ - 370 370 370 370 370 /* UA,NS,C,C */ - 370 370 370 370 370 /* UA,NS,C,G */ - 370 370 370 370 370 /* UA,NS,C,U */ - 370 260 370 260 370 /* UA,NS,G,E */ - 370 260 370 260 370 /* UA,NS,G,A */ - 370 260 370 260 370 /* UA,NS,G,C */ - 260 260 260 260 260 /* UA,NS,G,G */ - 370 260 370 260 370 /* UA,NS,G,U */ - 370 370 370 370 300 /* UA,NS,U,E */ - 370 370 370 370 300 /* UA,NS,U,A */ - 370 370 370 370 300 /* UA,NS,U,C */ - 370 370 370 370 300 /* UA,NS,U,G */ - 300 300 300 300 300 /* UA,NS,U,U */ - 300 300 300 300 300 /* NS,CG,E,E */ - 300 300 300 300 300 /* NS,CG,E,A */ - 300 300 300 300 300 /* NS,CG,E,C */ - 300 300 300 300 300 /* NS,CG,E,G */ - 300 300 300 300 300 /* NS,CG,E,U */ - 300 300 300 300 300 /* NS,CG,A,E */ - 300 300 300 300 300 /* NS,CG,A,A */ - 300 300 300 300 300 /* NS,CG,A,C */ - 190 190 190 190 190 /* NS,CG,A,G */ - 300 300 300 300 300 /* NS,CG,A,U */ - 300 300 300 300 300 /* NS,CG,C,E */ - 300 300 300 300 300 /* NS,CG,C,A */ - 300 300 300 300 300 /* NS,CG,C,C */ - 300 300 300 300 300 /* NS,CG,C,G */ - 300 300 300 300 300 /* NS,CG,C,U */ - 300 190 300 190 300 /* NS,CG,G,E */ - 190 190 190 190 190 /* NS,CG,G,A */ - 300 190 300 190 300 /* NS,CG,G,C */ - 190 190 190 190 190 /* NS,CG,G,G */ - 300 190 300 190 300 /* NS,CG,G,U */ - 300 300 300 300 220 /* NS,CG,U,E */ - 300 300 300 300 220 /* NS,CG,U,A */ - 300 300 300 300 220 /* NS,CG,U,C */ - 300 300 300 300 220 /* NS,CG,U,G */ - 220 220 220 220 220 /* NS,CG,U,U */ - 300 300 300 300 300 /* NS,GC,E,E */ - 300 300 300 300 300 /* NS,GC,E,A */ - 300 300 300 300 300 /* NS,GC,E,C */ - 300 300 300 300 300 /* NS,GC,E,G */ - 300 300 300 300 300 /* NS,GC,E,U */ - 300 300 300 300 300 /* NS,GC,A,E */ - 300 300 300 300 300 /* NS,GC,A,A */ - 300 300 300 300 300 /* NS,GC,A,C */ - 190 190 190 190 190 /* NS,GC,A,G */ - 300 300 300 300 300 /* NS,GC,A,U */ - 300 300 300 300 300 /* NS,GC,C,E */ - 300 300 300 300 300 /* NS,GC,C,A */ - 300 300 300 300 300 /* NS,GC,C,C */ - 300 300 300 300 300 /* NS,GC,C,G */ - 300 300 300 300 300 /* NS,GC,C,U */ - 300 190 300 190 300 /* NS,GC,G,E */ - 300 190 300 190 300 /* NS,GC,G,A */ - 300 190 300 190 300 /* NS,GC,G,C */ - 190 190 190 190 190 /* NS,GC,G,G */ - 300 190 300 190 300 /* NS,GC,G,U */ - 300 300 300 300 220 /* NS,GC,U,E */ - 300 300 300 300 220 /* NS,GC,U,A */ - 300 300 300 300 220 /* NS,GC,U,C */ - 300 300 300 300 220 /* NS,GC,U,G */ - 220 220 220 220 220 /* NS,GC,U,U */ - 370 370 370 370 370 /* NS,GU,E,E */ - 370 370 370 370 370 /* NS,GU,E,A */ - 370 370 370 370 370 /* NS,GU,E,C */ - 370 370 370 370 370 /* NS,GU,E,G */ - 370 370 370 370 370 /* NS,GU,E,U */ - 370 370 370 370 370 /* NS,GU,A,E */ - 370 370 370 370 370 /* NS,GU,A,A */ - 370 370 370 370 370 /* NS,GU,A,C */ - 260 260 260 260 260 /* NS,GU,A,G */ - 370 370 370 370 370 /* NS,GU,A,U */ - 370 370 370 370 370 /* NS,GU,C,E */ - 370 370 370 370 370 /* NS,GU,C,A */ - 370 370 370 370 370 /* NS,GU,C,C */ - 370 370 370 370 370 /* NS,GU,C,G */ - 370 370 370 370 370 /* NS,GU,C,U */ - 370 260 370 260 370 /* NS,GU,G,E */ - 370 260 370 260 370 /* NS,GU,G,A */ - 370 260 370 260 370 /* NS,GU,G,C */ - 260 260 260 260 260 /* NS,GU,G,G */ - 370 260 370 260 370 /* NS,GU,G,U */ - 370 370 370 370 300 /* NS,GU,U,E */ - 370 370 370 370 300 /* NS,GU,U,A */ - 370 370 370 370 300 /* NS,GU,U,C */ - 370 370 370 370 300 /* NS,GU,U,G */ - 300 300 300 300 300 /* NS,GU,U,U */ - 370 370 370 370 370 /* NS,UG,E,E */ - 370 370 370 370 370 /* NS,UG,E,A */ - 370 370 370 370 370 /* NS,UG,E,C */ - 370 370 370 370 370 /* NS,UG,E,G */ - 370 370 370 370 370 /* NS,UG,E,U */ - 370 370 370 370 370 /* NS,UG,A,E */ - 370 370 370 370 370 /* NS,UG,A,A */ - 370 370 370 370 370 /* NS,UG,A,C */ - 260 260 260 260 260 /* NS,UG,A,G */ - 370 370 370 370 370 /* NS,UG,A,U */ - 370 370 370 370 370 /* NS,UG,C,E */ - 370 370 370 370 370 /* NS,UG,C,A */ - 370 370 370 370 370 /* NS,UG,C,C */ - 370 370 370 370 370 /* NS,UG,C,G */ - 370 370 370 370 370 /* NS,UG,C,U */ - 370 260 370 260 370 /* NS,UG,G,E */ - 260 260 260 260 260 /* NS,UG,G,A */ - 370 260 370 260 370 /* NS,UG,G,C */ - 260 260 260 260 260 /* NS,UG,G,G */ - 370 260 370 260 370 /* NS,UG,G,U */ - 370 370 370 370 300 /* NS,UG,U,E */ - 370 370 370 370 300 /* NS,UG,U,A */ - 370 370 370 370 300 /* NS,UG,U,C */ - 370 370 370 370 300 /* NS,UG,U,G */ - 300 300 300 300 300 /* NS,UG,U,U */ - 370 370 370 370 370 /* NS,AU,E,E */ - 370 370 370 370 370 /* NS,AU,E,A */ - 370 370 370 370 370 /* NS,AU,E,C */ - 370 370 370 370 370 /* NS,AU,E,G */ - 370 370 370 370 370 /* NS,AU,E,U */ - 370 370 370 370 370 /* NS,AU,A,E */ - 370 370 370 370 370 /* NS,AU,A,A */ - 370 370 370 370 370 /* NS,AU,A,C */ - 260 260 260 260 260 /* NS,AU,A,G */ - 370 370 370 370 370 /* NS,AU,A,U */ - 370 370 370 370 370 /* NS,AU,C,E */ - 370 370 370 370 370 /* NS,AU,C,A */ - 370 370 370 370 370 /* NS,AU,C,C */ - 370 370 370 370 370 /* NS,AU,C,G */ - 370 370 370 370 370 /* NS,AU,C,U */ - 370 260 370 260 370 /* NS,AU,G,E */ - 370 260 370 260 370 /* NS,AU,G,A */ - 370 260 370 260 370 /* NS,AU,G,C */ - 260 260 260 260 260 /* NS,AU,G,G */ - 370 260 370 260 370 /* NS,AU,G,U */ - 370 370 370 370 300 /* NS,AU,U,E */ - 370 370 370 370 300 /* NS,AU,U,A */ - 370 370 370 370 300 /* NS,AU,U,C */ - 370 370 370 370 300 /* NS,AU,U,G */ - 300 300 300 300 300 /* NS,AU,U,U */ - 370 370 370 370 370 /* NS,UA,E,E */ - 370 370 370 370 370 /* NS,UA,E,A */ - 370 370 370 370 370 /* NS,UA,E,C */ - 370 370 370 370 370 /* NS,UA,E,G */ - 370 370 370 370 370 /* NS,UA,E,U */ - 370 370 370 370 370 /* NS,UA,A,E */ - 370 370 370 370 370 /* NS,UA,A,A */ - 370 370 370 370 370 /* NS,UA,A,C */ - 260 260 260 260 260 /* NS,UA,A,G */ - 370 370 370 370 370 /* NS,UA,A,U */ - 370 370 370 370 370 /* NS,UA,C,E */ - 370 370 370 370 370 /* NS,UA,C,A */ - 370 370 370 370 370 /* NS,UA,C,C */ - 370 370 370 370 370 /* NS,UA,C,G */ - 370 370 370 370 370 /* NS,UA,C,U */ - 370 260 370 260 370 /* NS,UA,G,E */ - 260 260 260 260 260 /* NS,UA,G,A */ - 370 260 370 260 370 /* NS,UA,G,C */ - 260 260 260 260 260 /* NS,UA,G,G */ - 370 260 370 260 370 /* NS,UA,G,U */ - 370 370 370 370 300 /* NS,UA,U,E */ - 370 370 370 370 300 /* NS,UA,U,A */ - 370 370 370 370 300 /* NS,UA,U,C */ - 370 370 370 370 300 /* NS,UA,U,G */ - 300 300 300 300 300 /* NS,UA,U,U */ - 370 370 370 370 370 /* NS,NS,E,E */ - 370 370 370 370 370 /* NS,NS,E,A */ - 370 370 370 370 370 /* NS,NS,E,C */ - 370 370 370 370 370 /* NS,NS,E,G */ - 370 370 370 370 370 /* NS,NS,E,U */ - 370 370 370 370 370 /* NS,NS,A,E */ - 370 370 370 370 370 /* NS,NS,A,A */ - 370 370 370 370 370 /* NS,NS,A,C */ - 260 260 260 260 260 /* NS,NS,A,G */ - 370 370 370 370 370 /* NS,NS,A,U */ - 370 370 370 370 370 /* NS,NS,C,E */ - 370 370 370 370 370 /* NS,NS,C,A */ - 370 370 370 370 370 /* NS,NS,C,C */ - 370 370 370 370 370 /* NS,NS,C,G */ - 370 370 370 370 370 /* NS,NS,C,U */ - 370 260 370 260 370 /* NS,NS,G,E */ - 370 260 370 260 370 /* NS,NS,G,A */ - 370 260 370 260 370 /* NS,NS,G,C */ - 260 260 260 260 260 /* NS,NS,G,G */ - 370 260 370 260 370 /* NS,NS,G,U */ - 370 370 370 370 300 /* NS,NS,U,E */ - 370 370 370 370 300 /* NS,NS,U,A */ - 370 370 370 370 300 /* NS,NS,U,C */ - 370 370 370 370 300 /* NS,NS,U,G */ - 300 300 300 300 300 /* NS,NS,U,U */ - -# int21_enthalpies - 350 350 350 350 350 /* CG,CG,E,E */ - 350 350 350 350 350 /* CG,CG,E,A */ - 350 350 350 350 350 /* CG,CG,E,C */ - 350 350 350 350 350 /* CG,CG,E,G */ - 350 350 350 350 350 /* CG,CG,E,U */ - 350 350 350 -230 350 /* CG,CG,A,E */ - 350 350 350 -230 350 /* CG,CG,A,A */ - 350 350 350 -230 350 /* CG,CG,A,C */ - -230 -230 -230 -230 -230 /* CG,CG,A,G */ - 350 350 350 -230 350 /* CG,CG,A,U */ - 350 350 350 350 350 /* CG,CG,C,E */ - 350 350 350 350 350 /* CG,CG,C,A */ - 350 350 350 350 350 /* CG,CG,C,C */ - 350 350 350 350 350 /* CG,CG,C,G */ - 350 350 350 350 350 /* CG,CG,C,U */ - 350 -230 350 -230 350 /* CG,CG,G,E */ - -230 -230 -230 -230 -230 /* CG,CG,G,A */ - 350 -230 350 -230 350 /* CG,CG,G,C */ - -230 -230 -230 -230 -230 /* CG,CG,G,G */ - 350 -230 350 -230 350 /* CG,CG,G,U */ - 350 350 350 350 -670 /* CG,CG,U,E */ - 350 350 350 350 -670 /* CG,CG,U,A */ - 350 350 350 350 -670 /* CG,CG,U,C */ - 350 350 350 350 -670 /* CG,CG,U,G */ - -670 -670 -670 -670 -670 /* CG,CG,U,U */ - 780 640 780 350 350 /* CG,GC,E,E */ - 350 350 350 350 350 /* CG,GC,E,A */ - 780 350 780 350 350 /* CG,GC,E,C */ - 350 350 350 350 350 /* CG,GC,E,G */ - 640 640 350 350 350 /* CG,GC,E,U */ - 350 350 350 250 350 /* CG,GC,A,E */ - 350 260 350 250 350 /* CG,GC,A,A */ - 350 350 -250 -230 350 /* CG,GC,A,C */ - -230 -230 -230 -230 -230 /* CG,GC,A,G */ - 350 350 350 -230 350 /* CG,GC,A,U */ - 780 640 780 350 350 /* CG,GC,C,E */ - 350 160 350 350 350 /* CG,GC,C,A */ - 780 350 780 350 350 /* CG,GC,C,C */ - 350 350 350 350 350 /* CG,GC,C,G */ - 640 640 350 350 350 /* CG,GC,C,U */ - 350 -160 350 -230 350 /* CG,GC,G,E */ - 350 -160 350 -410 350 /* CG,GC,G,A */ - 350 -230 350 -230 350 /* CG,GC,G,C */ - -230 -310 -230 -230 -230 /* CG,GC,G,G */ - 350 -230 350 -230 350 /* CG,GC,G,U */ - 580 350 580 350 -580 /* CG,GC,U,E */ - 350 350 350 350 -670 /* CG,GC,U,A */ - 580 350 580 350 -580 /* CG,GC,U,C */ - 350 350 350 350 -670 /* CG,GC,U,G */ - -670 -670 -690 -670 -700 /* CG,GC,U,U */ - 850 850 850 850 850 /* CG,GU,E,E */ - 850 850 850 850 850 /* CG,GU,E,A */ - 850 850 850 850 850 /* CG,GU,E,C */ - 850 850 850 850 850 /* CG,GU,E,G */ - 850 850 850 850 850 /* CG,GU,E,U */ - 850 850 850 280 850 /* CG,GU,A,E */ - 850 850 850 280 850 /* CG,GU,A,A */ - 850 850 850 280 850 /* CG,GU,A,C */ - 280 280 280 280 280 /* CG,GU,A,G */ - 850 850 850 280 850 /* CG,GU,A,U */ - 850 850 850 850 850 /* CG,GU,C,E */ - 850 850 850 850 850 /* CG,GU,C,A */ - 850 850 850 850 850 /* CG,GU,C,C */ - 850 850 850 850 850 /* CG,GU,C,G */ - 850 850 850 850 850 /* CG,GU,C,U */ - 850 280 850 280 850 /* CG,GU,G,E */ - 850 280 850 280 850 /* CG,GU,G,A */ - 850 280 850 280 850 /* CG,GU,G,C */ - 280 280 280 280 280 /* CG,GU,G,G */ - 850 280 850 280 850 /* CG,GU,G,U */ - 850 850 850 850 -160 /* CG,GU,U,E */ - 850 850 850 850 -160 /* CG,GU,U,A */ - 850 850 850 850 -160 /* CG,GU,U,C */ - 850 850 850 850 -160 /* CG,GU,U,G */ - -160 -160 -160 -160 -160 /* CG,GU,U,U */ - 850 850 850 850 850 /* CG,UG,E,E */ - 850 850 850 850 850 /* CG,UG,E,A */ - 850 850 850 850 850 /* CG,UG,E,C */ - 850 850 850 850 850 /* CG,UG,E,G */ - 850 850 850 850 850 /* CG,UG,E,U */ - 850 850 850 280 850 /* CG,UG,A,E */ - 850 850 850 280 850 /* CG,UG,A,A */ - 850 850 850 280 850 /* CG,UG,A,C */ - 280 280 280 280 280 /* CG,UG,A,G */ - 850 850 850 280 850 /* CG,UG,A,U */ - 850 850 850 850 850 /* CG,UG,C,E */ - 850 850 850 850 850 /* CG,UG,C,A */ - 850 850 850 850 850 /* CG,UG,C,C */ - 850 850 850 850 850 /* CG,UG,C,G */ - 850 850 850 850 850 /* CG,UG,C,U */ - 850 280 850 280 850 /* CG,UG,G,E */ - 280 280 280 280 280 /* CG,UG,G,A */ - 850 280 850 280 850 /* CG,UG,G,C */ - 280 280 280 280 280 /* CG,UG,G,G */ - 850 280 850 280 850 /* CG,UG,G,U */ - 850 850 850 850 -160 /* CG,UG,U,E */ - 850 850 850 850 -160 /* CG,UG,U,A */ - 850 850 850 850 -160 /* CG,UG,U,C */ - 850 850 850 850 -160 /* CG,UG,U,G */ - -160 -160 -160 -160 -160 /* CG,UG,U,U */ - 850 850 850 850 850 /* CG,AU,E,E */ - 850 850 850 850 850 /* CG,AU,E,A */ - 850 850 850 850 850 /* CG,AU,E,C */ - 850 850 850 850 850 /* CG,AU,E,G */ - 850 850 850 850 850 /* CG,AU,E,U */ - 850 850 850 280 850 /* CG,AU,A,E */ - 850 850 850 280 850 /* CG,AU,A,A */ - 850 850 850 280 850 /* CG,AU,A,C */ - 280 280 280 280 280 /* CG,AU,A,G */ - 850 850 850 280 850 /* CG,AU,A,U */ - 850 850 850 850 850 /* CG,AU,C,E */ - 850 850 850 850 850 /* CG,AU,C,A */ - 850 850 850 850 850 /* CG,AU,C,C */ - 850 850 850 850 850 /* CG,AU,C,G */ - 850 850 850 850 850 /* CG,AU,C,U */ - 850 280 850 280 850 /* CG,AU,G,E */ - 850 280 850 280 850 /* CG,AU,G,A */ - 850 280 850 280 850 /* CG,AU,G,C */ - 280 280 280 280 280 /* CG,AU,G,G */ - 850 280 850 280 850 /* CG,AU,G,U */ - 850 850 850 850 -160 /* CG,AU,U,E */ - 850 850 850 850 -160 /* CG,AU,U,A */ - 850 850 850 850 -160 /* CG,AU,U,C */ - 850 850 850 850 -160 /* CG,AU,U,G */ - -160 -160 -160 -160 -160 /* CG,AU,U,U */ - 850 850 850 850 850 /* CG,UA,E,E */ - 850 850 850 850 850 /* CG,UA,E,A */ - 850 850 850 850 850 /* CG,UA,E,C */ - 850 850 850 850 850 /* CG,UA,E,G */ - 850 850 850 850 850 /* CG,UA,E,U */ - 850 850 850 280 850 /* CG,UA,A,E */ - 850 850 850 280 850 /* CG,UA,A,A */ - 850 850 850 280 850 /* CG,UA,A,C */ - 280 280 280 280 280 /* CG,UA,A,G */ - 850 850 850 280 850 /* CG,UA,A,U */ - 850 850 850 850 850 /* CG,UA,C,E */ - 850 850 850 850 850 /* CG,UA,C,A */ - 850 850 850 850 850 /* CG,UA,C,C */ - 850 850 850 850 850 /* CG,UA,C,G */ - 850 850 850 850 850 /* CG,UA,C,U */ - 850 280 850 280 850 /* CG,UA,G,E */ - 280 280 280 280 280 /* CG,UA,G,A */ - 850 280 850 280 850 /* CG,UA,G,C */ - 280 280 280 280 280 /* CG,UA,G,G */ - 850 280 850 280 850 /* CG,UA,G,U */ - 850 850 850 850 -160 /* CG,UA,U,E */ - 850 850 850 850 -160 /* CG,UA,U,A */ - 850 850 850 850 -160 /* CG,UA,U,C */ - 850 850 850 850 -160 /* CG,UA,U,G */ - -160 -160 -160 -160 -160 /* CG,UA,U,U */ - 850 850 850 850 850 /* CG,NS,E,E */ - 850 850 850 850 850 /* CG,NS,E,A */ - 850 850 850 850 850 /* CG,NS,E,C */ - 850 850 850 850 850 /* CG,NS,E,G */ - 850 850 850 850 850 /* CG,NS,E,U */ - 850 850 850 280 850 /* CG,NS,A,E */ - 850 850 850 280 850 /* CG,NS,A,A */ - 850 850 850 280 850 /* CG,NS,A,C */ - 280 280 280 280 280 /* CG,NS,A,G */ - 850 850 850 280 850 /* CG,NS,A,U */ - 850 850 850 850 850 /* CG,NS,C,E */ - 850 850 850 850 850 /* CG,NS,C,A */ - 850 850 850 850 850 /* CG,NS,C,C */ - 850 850 850 850 850 /* CG,NS,C,G */ - 850 850 850 850 850 /* CG,NS,C,U */ - 850 280 850 280 850 /* CG,NS,G,E */ - 850 280 850 280 850 /* CG,NS,G,A */ - 850 280 850 280 850 /* CG,NS,G,C */ - 280 280 280 280 280 /* CG,NS,G,G */ - 850 280 850 280 850 /* CG,NS,G,U */ - 850 850 850 850 -160 /* CG,NS,U,E */ - 850 850 850 850 -160 /* CG,NS,U,A */ - 850 850 850 850 -160 /* CG,NS,U,C */ - 850 850 850 850 -160 /* CG,NS,U,G */ - -160 -160 -160 -160 -160 /* CG,NS,U,U */ - 690 690 350 350 350 /* GC,CG,E,E */ - 690 690 350 350 350 /* GC,CG,E,A */ - 350 350 350 350 350 /* GC,CG,E,C */ - 350 350 350 350 350 /* GC,CG,E,G */ - 350 350 350 350 350 /* GC,CG,E,U */ - 690 690 350 350 350 /* GC,CG,A,E */ - 690 690 350 240 350 /* GC,CG,A,A */ - 350 350 350 350 350 /* GC,CG,A,C */ - -230 -500 -230 -230 -230 /* GC,CG,A,G */ - 350 350 350 350 350 /* GC,CG,A,U */ - 350 350 350 350 350 /* GC,CG,C,E */ - 350 350 350 350 350 /* GC,CG,C,A */ - 350 350 350 350 350 /* GC,CG,C,C */ - 350 350 350 350 350 /* GC,CG,C,G */ - 350 350 130 350 350 /* GC,CG,C,U */ - 350 -230 350 -230 350 /* GC,CG,G,E */ - -230 -230 -230 -230 -230 /* GC,CG,G,A */ - 350 -230 350 -230 350 /* GC,CG,G,C */ - -230 -230 -230 -230 -230 /* GC,CG,G,G */ - 350 -230 350 -230 350 /* GC,CG,G,U */ - 350 350 350 350 -670 /* GC,CG,U,E */ - 350 350 350 350 -670 /* GC,CG,U,A */ - 350 350 350 350 -670 /* GC,CG,U,C */ - 350 350 350 350 -670 /* GC,CG,U,G */ - -670 -670 -670 -670 -670 /* GC,CG,U,U */ - 350 350 350 350 350 /* GC,GC,E,E */ - 350 350 350 350 350 /* GC,GC,E,A */ - 350 350 350 350 350 /* GC,GC,E,C */ - 350 350 350 350 350 /* GC,GC,E,G */ - 350 350 350 350 350 /* GC,GC,E,U */ - 350 350 350 350 350 /* GC,GC,A,E */ - 350 350 350 350 350 /* GC,GC,A,A */ - 350 350 350 350 350 /* GC,GC,A,C */ - -230 -230 -230 -230 -230 /* GC,GC,A,G */ - 350 350 350 350 350 /* GC,GC,A,U */ - 350 350 350 350 350 /* GC,GC,C,E */ - 350 350 350 350 350 /* GC,GC,C,A */ - 350 350 350 350 350 /* GC,GC,C,C */ - 350 350 350 350 350 /* GC,GC,C,G */ - 350 350 350 350 350 /* GC,GC,C,U */ - 350 -230 350 -230 350 /* GC,GC,G,E */ - 350 -230 350 -230 350 /* GC,GC,G,A */ - 350 -230 350 -230 350 /* GC,GC,G,C */ - -230 -230 -230 -230 -230 /* GC,GC,G,G */ - 350 -230 350 -230 350 /* GC,GC,G,U */ - 350 350 350 350 -670 /* GC,GC,U,E */ - 350 350 350 350 -670 /* GC,GC,U,A */ - 350 350 350 350 -670 /* GC,GC,U,C */ - 350 350 350 350 -670 /* GC,GC,U,G */ - -670 -670 -670 -670 -670 /* GC,GC,U,U */ - 850 850 850 850 850 /* GC,GU,E,E */ - 850 850 850 850 850 /* GC,GU,E,A */ - 850 850 850 850 850 /* GC,GU,E,C */ - 850 850 850 850 850 /* GC,GU,E,G */ - 850 850 850 850 850 /* GC,GU,E,U */ - 850 850 850 850 850 /* GC,GU,A,E */ - 850 850 850 850 850 /* GC,GU,A,A */ - 850 850 850 850 850 /* GC,GU,A,C */ - 280 280 280 280 280 /* GC,GU,A,G */ - 850 850 850 850 850 /* GC,GU,A,U */ - 850 850 850 850 850 /* GC,GU,C,E */ - 850 850 850 850 850 /* GC,GU,C,A */ - 850 850 850 850 850 /* GC,GU,C,C */ - 850 850 850 850 850 /* GC,GU,C,G */ - 850 850 850 850 850 /* GC,GU,C,U */ - 850 280 850 280 850 /* GC,GU,G,E */ - 850 280 850 280 850 /* GC,GU,G,A */ - 850 280 850 280 850 /* GC,GU,G,C */ - 280 280 280 280 280 /* GC,GU,G,G */ - 850 280 850 280 850 /* GC,GU,G,U */ - 850 850 850 850 -160 /* GC,GU,U,E */ - 850 850 850 850 -160 /* GC,GU,U,A */ - 850 850 850 850 -160 /* GC,GU,U,C */ - 850 850 850 850 -160 /* GC,GU,U,G */ - -160 -160 -160 -160 -160 /* GC,GU,U,U */ - 850 850 850 850 850 /* GC,UG,E,E */ - 850 850 850 850 850 /* GC,UG,E,A */ - 850 850 850 850 850 /* GC,UG,E,C */ - 850 850 850 850 850 /* GC,UG,E,G */ - 850 850 850 850 850 /* GC,UG,E,U */ - 850 850 850 850 850 /* GC,UG,A,E */ - 850 690 850 240 850 /* GC,UG,A,A */ - 850 850 850 850 850 /* GC,UG,A,C */ - 280 -500 280 280 280 /* GC,UG,A,G */ - 850 850 850 850 850 /* GC,UG,A,U */ - 850 850 850 850 850 /* GC,UG,C,E */ - 850 850 850 850 850 /* GC,UG,C,A */ - 850 850 850 850 850 /* GC,UG,C,C */ - 850 850 850 850 850 /* GC,UG,C,G */ - 850 850 130 850 850 /* GC,UG,C,U */ - 850 280 850 280 850 /* GC,UG,G,E */ - 280 280 280 280 280 /* GC,UG,G,A */ - 850 280 850 280 850 /* GC,UG,G,C */ - 280 280 280 280 280 /* GC,UG,G,G */ - 850 280 850 280 850 /* GC,UG,G,U */ - 850 850 850 850 -160 /* GC,UG,U,E */ - 850 850 850 850 -160 /* GC,UG,U,A */ - 850 850 850 850 -160 /* GC,UG,U,C */ - 850 850 850 850 -160 /* GC,UG,U,G */ - -160 -160 -160 -160 -160 /* GC,UG,U,U */ - 850 850 850 850 850 /* GC,AU,E,E */ - 850 850 850 850 850 /* GC,AU,E,A */ - 850 850 850 850 850 /* GC,AU,E,C */ - 850 850 850 850 850 /* GC,AU,E,G */ - 850 850 850 850 850 /* GC,AU,E,U */ - 850 850 850 850 850 /* GC,AU,A,E */ - 850 850 850 850 850 /* GC,AU,A,A */ - 850 850 850 850 850 /* GC,AU,A,C */ - 280 280 280 280 280 /* GC,AU,A,G */ - 850 850 850 850 850 /* GC,AU,A,U */ - 850 850 850 850 850 /* GC,AU,C,E */ - 850 850 850 850 850 /* GC,AU,C,A */ - 850 850 850 850 850 /* GC,AU,C,C */ - 850 850 850 850 850 /* GC,AU,C,G */ - 850 850 850 850 850 /* GC,AU,C,U */ - 850 280 850 280 850 /* GC,AU,G,E */ - 850 280 850 280 850 /* GC,AU,G,A */ - 850 280 850 280 850 /* GC,AU,G,C */ - 280 280 280 280 280 /* GC,AU,G,G */ - 850 280 850 280 850 /* GC,AU,G,U */ - 850 850 850 850 -160 /* GC,AU,U,E */ - 850 850 850 850 -160 /* GC,AU,U,A */ - 850 850 850 850 -160 /* GC,AU,U,C */ - 850 850 850 850 -160 /* GC,AU,U,G */ - -160 -160 -160 -160 -160 /* GC,AU,U,U */ - 850 850 850 850 850 /* GC,UA,E,E */ - 850 850 850 850 850 /* GC,UA,E,A */ - 850 850 850 850 850 /* GC,UA,E,C */ - 850 850 850 850 850 /* GC,UA,E,G */ - 850 850 850 850 850 /* GC,UA,E,U */ - 850 850 850 850 850 /* GC,UA,A,E */ - 850 850 850 850 850 /* GC,UA,A,A */ - 850 850 850 850 850 /* GC,UA,A,C */ - 280 280 280 280 280 /* GC,UA,A,G */ - 850 850 850 850 850 /* GC,UA,A,U */ - 850 850 850 850 850 /* GC,UA,C,E */ - 850 850 850 850 850 /* GC,UA,C,A */ - 850 850 850 850 850 /* GC,UA,C,C */ - 850 850 850 850 850 /* GC,UA,C,G */ - 850 850 850 850 850 /* GC,UA,C,U */ - 850 280 850 280 850 /* GC,UA,G,E */ - 280 280 280 280 280 /* GC,UA,G,A */ - 850 280 850 280 850 /* GC,UA,G,C */ - 280 280 280 280 280 /* GC,UA,G,G */ - 850 280 850 280 850 /* GC,UA,G,U */ - 850 850 850 850 -160 /* GC,UA,U,E */ - 850 850 850 850 -160 /* GC,UA,U,A */ - 850 850 850 850 -160 /* GC,UA,U,C */ - 850 850 850 850 -160 /* GC,UA,U,G */ - -160 -160 -160 -160 -160 /* GC,UA,U,U */ - 850 850 850 850 850 /* GC,NS,E,E */ - 850 850 850 850 850 /* GC,NS,E,A */ - 850 850 850 850 850 /* GC,NS,E,C */ - 850 850 850 850 850 /* GC,NS,E,G */ - 850 850 850 850 850 /* GC,NS,E,U */ - 850 850 850 850 850 /* GC,NS,A,E */ - 850 850 850 850 850 /* GC,NS,A,A */ - 850 850 850 850 850 /* GC,NS,A,C */ - 280 280 280 280 280 /* GC,NS,A,G */ - 850 850 850 850 850 /* GC,NS,A,U */ - 850 850 850 850 850 /* GC,NS,C,E */ - 850 850 850 850 850 /* GC,NS,C,A */ - 850 850 850 850 850 /* GC,NS,C,C */ - 850 850 850 850 850 /* GC,NS,C,G */ - 850 850 850 850 850 /* GC,NS,C,U */ - 850 280 850 280 850 /* GC,NS,G,E */ - 850 280 850 280 850 /* GC,NS,G,A */ - 850 280 850 280 850 /* GC,NS,G,C */ - 280 280 280 280 280 /* GC,NS,G,G */ - 850 280 850 280 850 /* GC,NS,G,U */ - 850 850 850 850 -160 /* GC,NS,U,E */ - 850 850 850 850 -160 /* GC,NS,U,A */ - 850 850 850 850 -160 /* GC,NS,U,C */ - 850 850 850 850 -160 /* GC,NS,U,G */ - -160 -160 -160 -160 -160 /* GC,NS,U,U */ - 850 850 850 850 850 /* GU,CG,E,E */ - 850 850 850 850 850 /* GU,CG,E,A */ - 850 850 850 850 850 /* GU,CG,E,C */ - 850 850 850 850 850 /* GU,CG,E,G */ - 850 850 850 850 850 /* GU,CG,E,U */ - 850 850 850 850 850 /* GU,CG,A,E */ - 850 690 850 240 850 /* GU,CG,A,A */ - 850 850 850 850 850 /* GU,CG,A,C */ - 280 -500 280 280 280 /* GU,CG,A,G */ - 850 850 850 850 850 /* GU,CG,A,U */ - 850 850 850 850 850 /* GU,CG,C,E */ - 850 850 850 850 850 /* GU,CG,C,A */ - 850 850 850 850 850 /* GU,CG,C,C */ - 850 850 850 850 850 /* GU,CG,C,G */ - 850 850 130 850 850 /* GU,CG,C,U */ - 850 280 850 280 850 /* GU,CG,G,E */ - 280 280 280 280 280 /* GU,CG,G,A */ - 850 280 850 280 850 /* GU,CG,G,C */ - 280 280 280 280 280 /* GU,CG,G,G */ - 850 280 850 280 850 /* GU,CG,G,U */ - 850 850 850 850 -160 /* GU,CG,U,E */ - 850 850 850 850 -160 /* GU,CG,U,A */ - 850 850 850 850 -160 /* GU,CG,U,C */ - 850 850 850 850 -160 /* GU,CG,U,G */ - -160 -160 -160 -160 -160 /* GU,CG,U,U */ - 850 850 850 850 850 /* GU,GC,E,E */ - 850 850 850 850 850 /* GU,GC,E,A */ - 850 850 850 850 850 /* GU,GC,E,C */ - 850 850 850 850 850 /* GU,GC,E,G */ - 850 850 850 850 850 /* GU,GC,E,U */ - 850 850 850 850 850 /* GU,GC,A,E */ - 850 850 850 850 850 /* GU,GC,A,A */ - 850 850 850 850 850 /* GU,GC,A,C */ - 280 280 280 280 280 /* GU,GC,A,G */ - 850 850 850 850 850 /* GU,GC,A,U */ - 850 850 850 850 850 /* GU,GC,C,E */ - 850 850 850 850 850 /* GU,GC,C,A */ - 850 850 850 850 850 /* GU,GC,C,C */ - 850 850 850 850 850 /* GU,GC,C,G */ - 850 850 850 850 850 /* GU,GC,C,U */ - 850 280 850 280 850 /* GU,GC,G,E */ - 850 280 850 280 850 /* GU,GC,G,A */ - 850 280 850 280 850 /* GU,GC,G,C */ - 280 280 280 280 280 /* GU,GC,G,G */ - 850 280 850 280 850 /* GU,GC,G,U */ - 850 850 850 850 -160 /* GU,GC,U,E */ - 850 850 850 850 -160 /* GU,GC,U,A */ - 850 850 850 850 -160 /* GU,GC,U,C */ - 850 850 850 850 -160 /* GU,GC,U,G */ - -160 -160 -160 -160 -160 /* GU,GC,U,U */ - 1350 1350 1350 1350 1350 /* GU,GU,E,E */ - 1350 1350 1350 1350 1350 /* GU,GU,E,A */ - 1350 1350 1350 1350 1350 /* GU,GU,E,C */ - 1350 1350 1350 1350 1350 /* GU,GU,E,G */ - 1350 1350 1350 1350 1350 /* GU,GU,E,U */ - 1350 1350 1350 1350 1350 /* GU,GU,A,E */ - 1350 1350 1350 1350 1350 /* GU,GU,A,A */ - 1350 1350 1350 1350 1350 /* GU,GU,A,C */ - 780 780 780 780 780 /* GU,GU,A,G */ - 1350 1350 1350 1350 1350 /* GU,GU,A,U */ - 1350 1350 1350 1350 1350 /* GU,GU,C,E */ - 1350 1350 1350 1350 1350 /* GU,GU,C,A */ - 1350 1350 1350 1350 1350 /* GU,GU,C,C */ - 1350 1350 1350 1350 1350 /* GU,GU,C,G */ - 1350 1350 1350 1350 1350 /* GU,GU,C,U */ - 1350 780 1350 780 1350 /* GU,GU,G,E */ - 1350 780 1350 780 1350 /* GU,GU,G,A */ - 1350 780 1350 780 1350 /* GU,GU,G,C */ - 780 780 780 780 780 /* GU,GU,G,G */ - 1350 780 1350 780 1350 /* GU,GU,G,U */ - 1350 1350 1350 1350 340 /* GU,GU,U,E */ - 1350 1350 1350 1350 340 /* GU,GU,U,A */ - 1350 1350 1350 1350 340 /* GU,GU,U,C */ - 1350 1350 1350 1350 340 /* GU,GU,U,G */ - 340 340 340 340 340 /* GU,GU,U,U */ - 1350 1350 1350 1350 1350 /* GU,UG,E,E */ - 1350 1350 1350 1350 1350 /* GU,UG,E,A */ - 1350 1350 1350 1350 1350 /* GU,UG,E,C */ - 1350 1350 1350 1350 1350 /* GU,UG,E,G */ - 1350 1350 1350 1350 1350 /* GU,UG,E,U */ - 1350 1350 1350 1350 1350 /* GU,UG,A,E */ - 1350 690 1350 240 1350 /* GU,UG,A,A */ - 1350 1350 1350 1350 1350 /* GU,UG,A,C */ - 780 -500 780 780 780 /* GU,UG,A,G */ - 1350 1350 1350 1350 1350 /* GU,UG,A,U */ - 1350 1350 1350 1350 1350 /* GU,UG,C,E */ - 1350 1350 1350 1350 1350 /* GU,UG,C,A */ - 1350 1350 1350 1350 1350 /* GU,UG,C,C */ - 1350 1350 1350 1350 1350 /* GU,UG,C,G */ - 1350 1350 130 1350 1350 /* GU,UG,C,U */ - 1350 780 1350 780 1350 /* GU,UG,G,E */ - 780 780 780 780 780 /* GU,UG,G,A */ - 1350 780 1350 780 1350 /* GU,UG,G,C */ - 780 780 780 780 780 /* GU,UG,G,G */ - 1350 780 1350 780 1350 /* GU,UG,G,U */ - 1350 1350 1350 1350 340 /* GU,UG,U,E */ - 1350 1350 1350 1350 340 /* GU,UG,U,A */ - 1350 1350 1350 1350 340 /* GU,UG,U,C */ - 1350 1350 1350 1350 340 /* GU,UG,U,G */ - 340 340 340 340 340 /* GU,UG,U,U */ - 1350 1350 1350 1350 1350 /* GU,AU,E,E */ - 1350 1350 1350 1350 1350 /* GU,AU,E,A */ - 1350 1350 1350 1350 1350 /* GU,AU,E,C */ - 1350 1350 1350 1350 1350 /* GU,AU,E,G */ - 1350 1350 1350 1350 1350 /* GU,AU,E,U */ - 1350 1350 1350 1350 1350 /* GU,AU,A,E */ - 1350 1350 1350 1350 1350 /* GU,AU,A,A */ - 1350 1350 1350 1350 1350 /* GU,AU,A,C */ - 780 780 780 780 780 /* GU,AU,A,G */ - 1350 1350 1350 1350 1350 /* GU,AU,A,U */ - 1350 1350 1350 1350 1350 /* GU,AU,C,E */ - 1350 1350 1350 1350 1350 /* GU,AU,C,A */ - 1350 1350 1350 1350 1350 /* GU,AU,C,C */ - 1350 1350 1350 1350 1350 /* GU,AU,C,G */ - 1350 1350 1350 1350 1350 /* GU,AU,C,U */ - 1350 780 1350 780 1350 /* GU,AU,G,E */ - 1350 780 1350 780 1350 /* GU,AU,G,A */ - 1350 780 1350 780 1350 /* GU,AU,G,C */ - 780 780 780 780 780 /* GU,AU,G,G */ - 1350 780 1350 780 1350 /* GU,AU,G,U */ - 1350 1350 1350 1350 340 /* GU,AU,U,E */ - 1350 1350 1350 1350 340 /* GU,AU,U,A */ - 1350 1350 1350 1350 340 /* GU,AU,U,C */ - 1350 1350 1350 1350 340 /* GU,AU,U,G */ - 340 340 340 340 340 /* GU,AU,U,U */ - 1350 1350 1350 1350 1350 /* GU,UA,E,E */ - 1350 1350 1350 1350 1350 /* GU,UA,E,A */ - 1350 1350 1350 1350 1350 /* GU,UA,E,C */ - 1350 1350 1350 1350 1350 /* GU,UA,E,G */ - 1350 1350 1350 1350 1350 /* GU,UA,E,U */ - 1350 1350 1350 1350 1350 /* GU,UA,A,E */ - 1350 1350 1350 1350 1350 /* GU,UA,A,A */ - 1350 1350 1350 1350 1350 /* GU,UA,A,C */ - 780 780 780 780 780 /* GU,UA,A,G */ - 1350 1350 1350 1350 1350 /* GU,UA,A,U */ - 1350 1350 1350 1350 1350 /* GU,UA,C,E */ - 1350 1350 1350 1350 1350 /* GU,UA,C,A */ - 1350 1350 1350 1350 1350 /* GU,UA,C,C */ - 1350 1350 1350 1350 1350 /* GU,UA,C,G */ - 1350 1350 1350 1350 1350 /* GU,UA,C,U */ - 1350 780 1350 780 1350 /* GU,UA,G,E */ - 780 780 780 780 780 /* GU,UA,G,A */ - 1350 780 1350 780 1350 /* GU,UA,G,C */ - 780 780 780 780 780 /* GU,UA,G,G */ - 1350 780 1350 780 1350 /* GU,UA,G,U */ - 1350 1350 1350 1350 340 /* GU,UA,U,E */ - 1350 1350 1350 1350 340 /* GU,UA,U,A */ - 1350 1350 1350 1350 340 /* GU,UA,U,C */ - 1350 1350 1350 1350 340 /* GU,UA,U,G */ - 340 340 340 340 340 /* GU,UA,U,U */ - 1350 1350 1350 1350 1350 /* GU,NS,E,E */ - 1350 1350 1350 1350 1350 /* GU,NS,E,A */ - 1350 1350 1350 1350 1350 /* GU,NS,E,C */ - 1350 1350 1350 1350 1350 /* GU,NS,E,G */ - 1350 1350 1350 1350 1350 /* GU,NS,E,U */ - 1350 1350 1350 1350 1350 /* GU,NS,A,E */ - 1350 1350 1350 1350 1350 /* GU,NS,A,A */ - 1350 1350 1350 1350 1350 /* GU,NS,A,C */ - 780 780 780 780 780 /* GU,NS,A,G */ - 1350 1350 1350 1350 1350 /* GU,NS,A,U */ - 1350 1350 1350 1350 1350 /* GU,NS,C,E */ - 1350 1350 1350 1350 1350 /* GU,NS,C,A */ - 1350 1350 1350 1350 1350 /* GU,NS,C,C */ - 1350 1350 1350 1350 1350 /* GU,NS,C,G */ - 1350 1350 1350 1350 1350 /* GU,NS,C,U */ - 1350 780 1350 780 1350 /* GU,NS,G,E */ - 1350 780 1350 780 1350 /* GU,NS,G,A */ - 1350 780 1350 780 1350 /* GU,NS,G,C */ - 780 780 780 780 780 /* GU,NS,G,G */ - 1350 780 1350 780 1350 /* GU,NS,G,U */ - 1350 1350 1350 1350 340 /* GU,NS,U,E */ - 1350 1350 1350 1350 340 /* GU,NS,U,A */ - 1350 1350 1350 1350 340 /* GU,NS,U,C */ - 1350 1350 1350 1350 340 /* GU,NS,U,G */ - 340 340 340 340 340 /* GU,NS,U,U */ - 850 850 850 850 850 /* UG,CG,E,E */ - 850 850 850 850 850 /* UG,CG,E,A */ - 850 850 850 850 850 /* UG,CG,E,C */ - 850 850 850 850 850 /* UG,CG,E,G */ - 850 850 850 850 850 /* UG,CG,E,U */ - 850 850 850 280 850 /* UG,CG,A,E */ - 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110 150 -70 150 /* CG,GC,A,A,C */ - -30 10 -160 -30 /* CG,GC,A,A,G */ - 110 150 10 150 /* CG,GC,A,A,U */ - 100 50 -100 140 /* CG,GC,A,C,A */ - 110 150 -60 150 /* CG,GC,A,C,C */ - 100 140 10 140 /* CG,GC,A,C,G */ - 110 150 70 150 /* CG,GC,A,C,U */ - 40 30 -70 30 /* CG,GC,A,G,A */ - 110 150 10 150 /* CG,GC,A,G,C */ - -30 -30 0 10 /* CG,GC,A,G,G */ - 110 150 10 150 /* CG,GC,A,G,U */ - 100 140 10 140 /* CG,GC,A,U,A */ - 110 150 80 150 /* CG,GC,A,U,C */ - 100 140 10 140 /* CG,GC,A,U,G */ - 150 0 90 70 /* CG,GC,A,U,U */ - 130 220 130 140 /* CG,GC,C,A,A */ - 100 130 100 120 /* CG,GC,C,A,C */ - -70 70 -70 0 /* CG,GC,C,A,G */ - 100 130 100 120 /* CG,GC,C,A,U */ - 110 190 100 110 /* CG,GC,C,C,A */ - 100 130 100 120 /* CG,GC,C,C,C */ - 100 130 100 110 /* CG,GC,C,C,G */ - 100 130 100 170 /* CG,GC,C,C,U */ - 70 70 -10 60 /* CG,GC,C,G,A */ - 100 130 100 120 /* CG,GC,C,G,C */ - -40 -10 -40 20 /* CG,GC,C,G,G */ - 100 130 100 120 /* CG,GC,C,G,U */ - 100 130 100 110 /* CG,GC,C,U,A */ - 110 140 110 120 /* CG,GC,C,U,C */ - 100 130 100 110 /* CG,GC,C,U,G */ - -20 -10 30 20 /* CG,GC,C,U,U */ - -20 170 -10 170 /* CG,GC,G,A,A */ - -40 150 -40 150 /* CG,GC,G,A,C */ - -170 -30 -90 -30 /* CG,GC,G,A,G */ - 10 150 -40 150 /* CG,GC,G,A,U */ - 70 140 -50 140 /* CG,GC,G,C,A */ - 70 150 -40 150 /* CG,GC,G,C,C */ - 10 140 -50 140 /* CG,GC,G,C,G */ - 70 150 20 150 /* CG,GC,G,C,U */ - -50 30 -30 30 /* CG,GC,G,G,A */ - 10 150 -40 150 /* CG,GC,G,G,C */ - -30 10 80 10 /* CG,GC,G,G,G */ - 10 150 -40 150 /* CG,GC,G,G,U */ - 10 140 -50 140 /* CG,GC,G,U,A */ - 80 150 -50 150 /* CG,GC,G,U,C */ - 10 140 -50 140 /* CG,GC,G,U,G */ - 90 70 140 70 /* CG,GC,G,U,U */ - 130 140 130 140 /* CG,GC,U,A,A */ - 100 120 100 30 /* CG,GC,U,A,C */ - -70 0 -70 50 /* CG,GC,U,A,G */ - 100 120 100 30 /* CG,GC,U,A,U */ - 100 110 100 30 /* CG,GC,U,C,A */ - 100 120 100 30 /* CG,GC,U,C,C */ - 100 110 100 20 /* CG,GC,U,C,G */ - 100 120 100 30 /* CG,GC,U,C,U */ - -10 50 -10 140 /* CG,GC,U,G,A */ - 100 120 100 30 /* CG,GC,U,G,C */ - -40 -60 -40 70 /* CG,GC,U,G,G */ - 100 120 100 30 /* CG,GC,U,G,U */ - 100 110 100 20 /* CG,GC,U,U,A */ - 110 120 110 30 /* CG,GC,U,U,C */ - 100 110 100 20 /* CG,GC,U,U,G */ - 30 40 30 -60 /* CG,GC,U,U,U */ - 270 300 170 300 /* CG,GU,A,A,A */ - 230 270 130 270 /* CG,GU,A,A,C */ - 150 190 50 190 /* CG,GU,A,A,G */ - 230 270 130 270 /* CG,GU,A,A,U */ - 230 270 130 270 /* CG,GU,A,C,A */ - 230 270 190 270 /* CG,GU,A,C,C */ - 230 270 130 270 /* CG,GU,A,C,G */ - 230 270 190 270 /* CG,GU,A,C,U */ - 190 230 90 230 /* CG,GU,A,G,A */ - 230 270 130 270 /* CG,GU,A,G,C */ - 100 140 130 140 /* CG,GU,A,G,G */ - 230 270 130 270 /* CG,GU,A,G,U */ - 230 270 130 270 /* CG,GU,A,U,A */ - 230 270 190 270 /* CG,GU,A,U,C */ - 230 270 130 270 /* CG,GU,A,U,G */ - 290 270 130 270 /* CG,GU,A,U,U */ - 260 290 260 270 /* CG,GU,C,A,A */ - 220 250 220 240 /* CG,GU,C,A,C */ - 140 230 140 220 /* CG,GU,C,A,G */ - 220 250 220 240 /* CG,GU,C,A,U */ - 220 250 220 240 /* CG,GU,C,C,A */ - 220 250 220 240 /* CG,GU,C,C,C */ - 220 250 220 240 /* CG,GU,C,C,G */ - 220 250 220 240 /* CG,GU,C,C,U */ - 180 270 180 260 /* CG,GU,C,G,A */ - 220 250 220 240 /* CG,GU,C,G,C */ - 90 120 90 110 /* CG,GU,C,G,G */ - 220 250 220 240 /* CG,GU,C,G,U */ - 220 250 220 240 /* CG,GU,C,U,A */ - 220 250 220 240 /* CG,GU,C,U,C */ - 220 250 220 240 /* CG,GU,C,U,G */ - 220 250 220 240 /* CG,GU,C,U,U */ - 170 300 110 300 /* CG,GU,G,A,A */ - 130 270 80 270 /* CG,GU,G,A,C */ - 50 190 130 190 /* CG,GU,G,A,G */ - 130 270 80 270 /* CG,GU,G,A,U */ - 130 270 80 270 /* CG,GU,G,C,A */ - 190 270 80 270 /* CG,GU,G,C,C */ - 130 270 80 270 /* CG,GU,G,C,G */ - 190 270 80 270 /* CG,GU,G,C,U */ - 90 230 170 230 /* CG,GU,G,G,A */ - 130 270 80 270 /* CG,GU,G,G,C */ - 130 140 210 140 /* CG,GU,G,G,G */ - 130 270 80 270 /* CG,GU,G,G,U */ - 130 270 80 270 /* CG,GU,G,U,A */ - 190 270 80 270 /* CG,GU,G,U,C */ - 130 270 80 270 /* CG,GU,G,U,G */ - 130 270 210 270 /* CG,GU,G,U,U */ - 260 270 260 240 /* CG,GU,U,A,A */ - 220 240 220 150 /* CG,GU,U,A,C */ - 140 220 140 70 /* CG,GU,U,A,G */ - 220 240 220 150 /* CG,GU,U,A,U */ - 220 240 220 150 /* CG,GU,U,C,A */ - 220 240 220 150 /* CG,GU,U,C,C */ - 220 240 220 150 /* CG,GU,U,C,G */ - 220 240 220 150 /* CG,GU,U,C,U */ - 180 260 180 110 /* CG,GU,U,G,A */ - 220 240 220 150 /* CG,GU,U,G,C */ - 90 110 90 150 /* CG,GU,U,G,G */ - 220 240 220 150 /* CG,GU,U,G,U */ - 220 240 220 150 /* CG,GU,U,U,A */ - 220 240 220 150 /* CG,GU,U,U,C */ - 220 240 220 150 /* CG,GU,U,U,G */ - 220 240 220 150 /* CG,GU,U,U,U */ - 160 200 70 200 /* CG,UG,A,A,A */ - 200 240 100 240 /* CG,UG,A,A,C */ - 60 100 -30 100 /* CG,UG,A,A,G */ - 200 240 100 240 /* CG,UG,A,A,U */ - 200 240 100 240 /* CG,UG,A,C,A */ - 200 240 160 240 /* CG,UG,A,C,C */ - 200 240 100 240 /* CG,UG,A,C,G */ - 200 240 160 240 /* CG,UG,A,C,U */ - 230 270 130 270 /* CG,UG,A,G,A */ - 200 240 100 240 /* CG,UG,A,G,C */ - 70 110 100 110 /* CG,UG,A,G,G */ - 200 240 100 240 /* CG,UG,A,G,U */ - 200 240 100 240 /* CG,UG,A,U,A */ - 200 240 160 240 /* CG,UG,A,U,C */ - 200 240 100 240 /* CG,UG,A,U,G */ - 260 240 100 240 /* CG,UG,A,U,U */ - 160 190 160 170 /* CG,UG,C,A,A */ - 190 220 190 210 /* CG,UG,C,A,C */ - 60 150 60 130 /* CG,UG,C,A,G */ - 190 220 190 210 /* CG,UG,C,A,U */ - 190 220 190 210 /* CG,UG,C,C,A */ - 190 220 190 210 /* CG,UG,C,C,C */ - 190 220 190 210 /* CG,UG,C,C,G */ - 190 220 190 210 /* CG,UG,C,C,U */ - 220 310 220 300 /* CG,UG,C,G,A */ - 190 220 190 210 /* CG,UG,C,G,C */ - 60 90 60 80 /* CG,UG,C,G,G */ - 190 220 190 210 /* CG,UG,C,G,U */ - 190 220 190 210 /* CG,UG,C,U,A */ - 190 220 190 210 /* CG,UG,C,U,C */ - 190 220 190 210 /* CG,UG,C,U,G */ - 190 220 190 210 /* CG,UG,C,U,U */ - 70 200 10 200 /* CG,UG,G,A,A */ - 100 240 50 240 /* CG,UG,G,A,C */ - -30 100 40 100 /* CG,UG,G,A,G */ - 100 240 50 240 /* CG,UG,G,A,U */ - 100 240 50 240 /* CG,UG,G,C,A */ - 160 240 50 240 /* CG,UG,G,C,C */ - 100 240 50 240 /* CG,UG,G,C,G */ - 160 240 50 240 /* CG,UG,G,C,U */ - 130 270 210 270 /* CG,UG,G,G,A */ - 100 240 50 240 /* CG,UG,G,G,C */ - 100 110 180 110 /* CG,UG,G,G,G */ - 100 240 50 240 /* CG,UG,G,G,U */ - 100 240 50 240 /* CG,UG,G,U,A */ - 160 240 50 240 /* CG,UG,G,U,C */ - 100 240 50 240 /* CG,UG,G,U,G */ - 100 240 180 240 /* CG,UG,G,U,U */ - 160 170 160 140 /* CG,UG,U,A,A */ - 190 210 190 120 /* CG,UG,U,A,C */ - 60 130 60 -10 /* CG,UG,U,A,G */ - 190 210 190 120 /* CG,UG,U,A,U */ - 190 210 190 120 /* CG,UG,U,C,A */ - 190 210 190 120 /* CG,UG,U,C,C */ - 190 210 190 120 /* CG,UG,U,C,G */ - 190 210 190 120 /* CG,UG,U,C,U */ - 220 300 220 150 /* CG,UG,U,G,A */ - 190 210 190 120 /* CG,UG,U,G,C */ - 60 80 60 120 /* CG,UG,U,G,G */ - 190 210 190 120 /* CG,UG,U,G,U */ - 190 210 190 120 /* CG,UG,U,U,A */ - 190 210 190 120 /* CG,UG,U,U,C */ - 190 210 190 120 /* CG,UG,U,U,G */ - 190 210 190 120 /* CG,UG,U,U,U */ - 200 240 100 240 /* CG,AU,A,A,A */ - 170 210 80 210 /* CG,AU,A,A,C */ - 70 110 -20 110 /* CG,AU,A,A,G */ - 170 210 80 210 /* CG,AU,A,A,U */ - 180 220 90 220 /* CG,AU,A,C,A */ - 180 220 140 220 /* CG,AU,A,C,C */ - 180 220 90 220 /* CG,AU,A,C,G */ - 180 220 140 220 /* CG,AU,A,C,U */ - 140 180 50 180 /* CG,AU,A,G,A */ - 170 210 80 210 /* CG,AU,A,G,C */ - 20 60 60 60 /* CG,AU,A,G,G */ - 170 210 80 210 /* CG,AU,A,G,U */ - 180 220 90 220 /* CG,AU,A,U,A */ - 180 220 140 220 /* CG,AU,A,U,C */ - 180 220 90 220 /* CG,AU,A,U,G */ - 150 130 0 130 /* CG,AU,A,U,U */ - 190 220 190 210 /* CG,AU,C,A,A */ - 170 200 170 180 /* CG,AU,C,A,C */ - 70 160 70 140 /* CG,AU,C,A,G */ - 170 200 170 180 /* CG,AU,C,A,U */ - 180 210 180 190 /* CG,AU,C,C,A */ - 170 200 170 190 /* CG,AU,C,C,C */ - 180 210 180 190 /* CG,AU,C,C,G */ - 170 200 170 190 /* CG,AU,C,C,U */ - 140 230 140 210 /* CG,AU,C,G,A */ - 170 200 170 180 /* CG,AU,C,G,C */ - 20 50 20 30 /* CG,AU,C,G,G */ - 170 200 170 180 /* CG,AU,C,G,U */ - 180 210 180 190 /* CG,AU,C,U,A */ - 170 200 170 190 /* CG,AU,C,U,C */ - 180 210 180 190 /* CG,AU,C,U,G */ - 80 110 80 100 /* CG,AU,C,U,U */ - 100 240 50 240 /* CG,AU,G,A,A */ - 80 210 20 210 /* CG,AU,G,A,C */ - -20 110 50 110 /* CG,AU,G,A,G */ - 80 210 20 210 /* CG,AU,G,A,U */ - 90 220 30 220 /* CG,AU,G,C,A */ - 140 220 30 220 /* CG,AU,G,C,C */ - 90 220 30 220 /* CG,AU,G,C,G */ - 140 220 30 220 /* CG,AU,G,C,U */ - 50 180 120 180 /* CG,AU,G,G,A */ - 80 210 20 210 /* CG,AU,G,G,C */ - 60 60 130 60 /* CG,AU,G,G,G */ - 80 210 20 210 /* CG,AU,G,G,U */ - 90 220 30 220 /* CG,AU,G,U,A */ - 140 220 30 220 /* CG,AU,G,U,C */ - 90 220 30 220 /* CG,AU,G,U,G */ - 0 130 70 130 /* CG,AU,G,U,U */ - 190 210 190 180 /* CG,AU,U,A,A */ - 170 180 170 90 /* CG,AU,U,A,C */ - 70 140 70 0 /* CG,AU,U,A,G */ - 170 180 170 90 /* CG,AU,U,A,U */ - 180 190 180 100 /* CG,AU,U,C,A */ - 170 190 170 100 /* CG,AU,U,C,C */ - 180 190 180 100 /* CG,AU,U,C,G */ - 170 190 170 100 /* CG,AU,U,C,U */ - 140 210 140 60 /* CG,AU,U,G,A */ - 170 180 170 90 /* CG,AU,U,G,C */ - 20 30 20 70 /* CG,AU,U,G,G */ - 170 180 170 90 /* CG,AU,U,G,U */ - 180 190 180 100 /* CG,AU,U,U,A */ - 170 190 170 100 /* CG,AU,U,U,C */ - 180 190 180 100 /* CG,AU,U,U,G */ - 80 100 80 10 /* CG,AU,U,U,U */ - 200 240 100 240 /* CG,UA,A,A,A */ - 150 190 60 190 /* CG,UA,A,A,C */ - 90 130 0 130 /* CG,UA,A,A,G */ - 150 190 60 190 /* CG,UA,A,A,U */ - 200 240 100 240 /* CG,UA,A,C,A */ - 200 240 160 240 /* CG,UA,A,C,C */ - 200 240 100 240 /* CG,UA,A,C,G */ - 200 240 160 240 /* CG,UA,A,C,U */ - 100 140 10 140 /* CG,UA,A,G,A */ - 150 190 60 190 /* CG,UA,A,G,C */ - 40 80 80 80 /* CG,UA,A,G,G */ - 150 190 60 190 /* CG,UA,A,G,U */ - 200 240 100 240 /* CG,UA,A,U,A */ - 170 210 130 210 /* CG,UA,A,U,C */ - 200 240 100 240 /* CG,UA,A,U,G */ - 170 150 20 150 /* CG,UA,A,U,U */ - 190 220 190 210 /* CG,UA,C,A,A */ - 150 180 150 160 /* CG,UA,C,A,C */ - 90 180 90 160 /* CG,UA,C,A,G */ - 150 180 150 160 /* CG,UA,C,A,U */ - 190 220 190 210 /* CG,UA,C,C,A */ - 190 220 190 210 /* CG,UA,C,C,C */ - 190 220 190 210 /* CG,UA,C,C,G */ - 190 220 190 210 /* CG,UA,C,C,U */ - 100 190 100 170 /* CG,UA,C,G,A */ - 150 180 150 160 /* CG,UA,C,G,C */ - 40 70 40 50 /* CG,UA,C,G,G */ - 150 180 150 160 /* CG,UA,C,G,U */ - 190 220 190 210 /* CG,UA,C,U,A */ - 160 190 160 180 /* CG,UA,C,U,C */ - 190 220 190 210 /* CG,UA,C,U,G */ - 110 140 110 120 /* CG,UA,C,U,U */ - 100 240 50 240 /* CG,UA,G,A,A */ - 60 190 0 190 /* CG,UA,G,A,C */ - 0 130 70 130 /* CG,UA,G,A,G */ - 60 190 0 190 /* CG,UA,G,A,U */ - 100 240 50 240 /* CG,UA,G,C,A */ - 160 240 50 240 /* CG,UA,G,C,C */ - 100 240 50 240 /* CG,UA,G,C,G */ - 160 240 50 240 /* CG,UA,G,C,U */ - 10 140 80 140 /* CG,UA,G,G,A */ - 60 190 0 190 /* CG,UA,G,G,C */ - 80 80 150 80 /* CG,UA,G,G,G */ - 60 190 0 190 /* CG,UA,G,G,U */ - 100 240 50 240 /* CG,UA,G,U,A */ - 130 210 20 210 /* CG,UA,G,U,C */ - 100 240 50 240 /* CG,UA,G,U,G */ - 20 150 90 150 /* CG,UA,G,U,U */ - 190 210 190 180 /* CG,UA,U,A,A */ - 150 160 150 70 /* CG,UA,U,A,C */ - 90 160 90 10 /* CG,UA,U,A,G */ - 150 160 150 70 /* CG,UA,U,A,U */ - 190 210 190 120 /* CG,UA,U,C,A */ - 190 210 190 120 /* CG,UA,U,C,C */ - 190 210 190 120 /* CG,UA,U,C,G */ - 190 210 190 120 /* CG,UA,U,C,U */ - 100 170 100 20 /* CG,UA,U,G,A */ - 150 160 150 70 /* CG,UA,U,G,C */ - 40 50 40 90 /* CG,UA,U,G,G */ - 150 160 150 70 /* CG,UA,U,G,U */ - 190 210 190 120 /* CG,UA,U,U,A */ - 160 180 160 90 /* CG,UA,U,U,C */ - 190 210 190 120 /* CG,UA,U,U,G */ - 110 120 110 30 /* CG,UA,U,U,U */ - 130 100 40 100 /* GC,CG,A,A,A */ - 130 110 70 100 /* GC,CG,A,A,C */ - -20 70 -50 10 /* GC,CG,A,A,G */ - 130 100 -10 100 /* GC,CG,A,A,U */ - 60 50 30 140 /* GC,CG,A,C,A */ - 220 190 70 130 /* GC,CG,A,C,C */ - 170 140 30 140 /* GC,CG,A,C,G */ - 140 110 50 110 /* GC,CG,A,C,U */ - 0 -100 -70 10 /* GC,CG,A,G,A */ - 130 100 -10 100 /* GC,CG,A,G,C */ - -10 -50 -30 -50 /* GC,CG,A,G,G */ - 130 100 -10 100 /* GC,CG,A,G,U */ - 170 140 30 140 /* GC,CG,A,U,A */ - 140 110 60 110 /* GC,CG,A,U,C */ - 170 140 30 140 /* GC,CG,A,U,G */ - 140 30 140 20 /* GC,CG,A,U,U */ - 110 110 110 110 /* GC,CG,C,A,A */ - 100 100 100 110 /* GC,CG,C,A,C */ - -40 70 10 80 /* GC,CG,C,A,G */ - 100 100 100 110 /* GC,CG,C,A,U */ - 150 150 150 150 /* GC,CG,C,C,A */ - 130 130 130 140 /* GC,CG,C,C,C */ - 150 150 150 150 /* GC,CG,C,C,G */ - 120 120 120 120 /* GC,CG,C,C,U */ - -70 -60 10 80 /* GC,CG,C,G,A */ - 100 100 100 110 /* GC,CG,C,G,C */ - -40 -40 -40 -50 /* GC,CG,C,G,G */ - 100 100 100 110 /* GC,CG,C,G,U */ - 150 150 150 150 /* GC,CG,C,U,A */ - 120 120 120 120 /* GC,CG,C,U,C */ - 150 150 150 150 /* GC,CG,C,U,G */ - 30 30 30 30 /* GC,CG,C,U,U */ - -30 100 -30 100 /* GC,CG,G,A,A */ - -70 100 -40 100 /* GC,CG,G,A,C */ - -170 10 -30 10 /* GC,CG,G,A,G */ - -70 100 -40 100 /* GC,CG,G,A,U */ - 10 140 -30 140 /* GC,CG,G,C,A */ - 70 130 -10 130 /* GC,CG,G,C,C */ - -30 140 10 140 /* GC,CG,G,C,G */ - 0 110 -60 110 /* GC,CG,G,C,U */ - -160 10 0 10 /* GC,CG,G,G,A */ - -70 100 -40 100 /* GC,CG,G,G,C */ - -90 -50 80 -50 /* GC,CG,G,G,G */ - -70 100 -40 100 /* GC,CG,G,G,U */ - -30 140 10 140 /* GC,CG,G,U,A */ - 0 110 20 110 /* GC,CG,G,U,C */ - -30 140 10 140 /* GC,CG,G,U,G */ - 50 20 70 20 /* GC,CG,G,U,U */ - 110 110 110 150 /* GC,CG,U,A,A */ - 100 100 100 -20 /* GC,CG,U,A,C */ - 10 70 10 90 /* GC,CG,U,A,G */ - 100 100 100 30 /* GC,CG,U,A,U */ - 150 150 150 0 /* GC,CG,U,C,A */ - 130 130 130 -10 /* GC,CG,U,C,C */ - 150 150 150 70 /* GC,CG,U,C,G */ - 120 120 120 40 /* GC,CG,U,C,U */ - 10 70 10 90 /* GC,CG,U,G,A */ - 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90 90 90 100 /* GC,GC,C,C,G */ - 100 100 100 100 /* GC,GC,C,C,U */ - -10 50 -10 50 /* GC,GC,C,G,A */ - 100 100 100 100 /* GC,GC,C,G,C */ - -40 -40 -40 -40 /* GC,GC,C,G,G */ - 100 100 100 100 /* GC,GC,C,G,U */ - 90 90 90 100 /* GC,GC,C,U,A */ - 100 100 100 110 /* GC,GC,C,U,C */ - 90 90 90 100 /* GC,GC,C,U,G */ - 20 20 20 30 /* GC,GC,C,U,U */ - -50 120 -20 120 /* GC,GC,G,A,A */ - -80 90 -40 90 /* GC,GC,G,A,C */ - -260 -80 -90 -80 /* GC,GC,G,A,G */ - -80 90 -40 90 /* GC,GC,G,A,U */ - -80 90 -50 90 /* GC,GC,G,C,A */ - -20 90 -40 90 /* GC,GC,G,C,C */ - -80 90 -50 90 /* GC,GC,G,C,G */ - -20 90 -40 90 /* GC,GC,G,C,U */ - -190 -20 -20 -20 /* GC,GC,G,G,A */ - -80 90 -40 90 /* GC,GC,G,G,C */ - -90 -50 80 -50 /* GC,GC,G,G,G */ - -80 90 -40 90 /* GC,GC,G,G,U */ - -80 90 -50 90 /* GC,GC,G,U,A */ - -10 100 -40 100 /* GC,GC,G,U,C */ - -80 90 -50 90 /* GC,GC,G,U,G */ - -150 20 10 20 /* GC,GC,G,U,U */ - 120 120 120 110 /* GC,GC,U,A,A */ - 100 100 100 20 /* GC,GC,U,A,C */ - -80 -20 -80 -150 /* GC,GC,U,A,G */ - 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140 140 140 150 /* GC,UA,C,G,U */ - 190 190 190 190 /* GC,UA,C,U,A */ - 160 160 160 160 /* GC,UA,C,U,C */ - 190 190 190 190 /* GC,UA,C,U,G */ - 100 100 100 110 /* GC,UA,C,U,U */ - 10 180 50 180 /* GC,UA,G,A,A */ - -30 140 0 140 /* GC,UA,G,A,C */ - -90 80 70 80 /* GC,UA,G,A,G */ - -30 140 0 140 /* GC,UA,G,A,U */ - 10 180 50 180 /* GC,UA,G,C,A */ - 70 180 50 180 /* GC,UA,G,C,C */ - 10 180 50 180 /* GC,UA,G,C,G */ - 70 180 50 180 /* GC,UA,G,C,U */ - -80 90 80 90 /* GC,UA,G,G,A */ - -30 140 0 140 /* GC,UA,G,G,C */ - -10 30 150 30 /* GC,UA,G,G,G */ - -30 140 0 140 /* GC,UA,G,G,U */ - 10 180 50 180 /* GC,UA,G,U,A */ - 40 150 20 150 /* GC,UA,G,U,C */ - 10 180 50 180 /* GC,UA,G,U,G */ - -70 100 90 100 /* GC,UA,G,U,U */ - 190 190 190 170 /* GC,UA,U,A,A */ - 140 140 140 70 /* GC,UA,U,A,C */ - 80 140 80 10 /* GC,UA,U,A,G */ - 140 140 140 70 /* GC,UA,U,A,U */ - 190 190 190 110 /* GC,UA,U,C,A */ - 190 190 190 110 /* GC,UA,U,C,C */ - 190 190 190 110 /* GC,UA,U,C,G */ - 190 190 190 110 /* GC,UA,U,C,U */ - 90 150 90 20 /* GC,UA,U,G,A */ - 140 140 140 70 /* GC,UA,U,G,C */ - 30 30 30 90 /* GC,UA,U,G,G */ - 140 140 140 70 /* GC,UA,U,G,U */ - 190 190 190 110 /* GC,UA,U,U,A */ - 160 160 160 80 /* GC,UA,U,U,C */ - 190 190 190 110 /* GC,UA,U,U,G */ - 100 100 100 30 /* GC,UA,U,U,U */ - 270 230 190 230 /* GU,CG,A,A,A */ - 260 220 180 220 /* GU,CG,A,A,C */ - 170 130 90 130 /* GU,CG,A,A,G */ - 260 220 180 220 /* GU,CG,A,A,U */ - 300 270 230 270 /* GU,CG,A,C,A */ - 290 250 270 250 /* GU,CG,A,C,C */ - 300 270 230 270 /* GU,CG,A,C,G */ - 270 240 260 240 /* GU,CG,A,C,U */ - 170 130 90 130 /* GU,CG,A,G,A */ - 260 220 180 220 /* GU,CG,A,G,C */ - 110 80 170 80 /* GU,CG,A,G,G */ - 260 220 180 220 /* GU,CG,A,G,U */ - 300 270 230 270 /* GU,CG,A,U,A */ - 270 240 260 240 /* GU,CG,A,U,C */ - 300 270 230 270 /* GU,CG,A,U,G */ - 240 150 110 150 /* GU,CG,A,U,U */ - 230 230 230 230 /* GU,CG,C,A,A */ - 220 220 220 220 /* GU,CG,C,A,C */ - 130 190 130 190 /* GU,CG,C,A,G */ - 220 220 220 220 /* GU,CG,C,A,U */ - 270 270 270 270 /* GU,CG,C,C,A */ - 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290 290 290 290 /* GU,AU,C,C,C */ - 290 290 290 290 /* GU,AU,C,C,G */ - 290 290 290 290 /* GU,AU,C,C,U */ - 250 310 250 310 /* GU,AU,C,G,A */ - 280 280 280 280 /* GU,AU,C,G,C */ - 130 130 130 130 /* GU,AU,C,G,G */ - 280 280 280 280 /* GU,AU,C,G,U */ - 290 290 290 290 /* GU,AU,C,U,A */ - 290 290 290 290 /* GU,AU,C,U,C */ - 290 290 290 290 /* GU,AU,C,U,G */ - 200 200 200 200 /* GU,AU,C,U,U */ - 230 310 180 310 /* GU,AU,G,A,A */ - 200 280 150 280 /* GU,AU,G,A,C */ - 100 180 180 180 /* GU,AU,G,A,G */ - 200 280 150 280 /* GU,AU,G,A,U */ - 210 290 160 290 /* GU,AU,G,C,A */ - 270 290 160 290 /* GU,AU,G,C,C */ - 210 290 160 290 /* GU,AU,G,C,G */ - 270 290 160 290 /* GU,AU,G,C,U */ - 170 250 250 250 /* GU,AU,G,G,A */ - 200 280 150 280 /* GU,AU,G,G,C */ - 180 130 260 130 /* GU,AU,G,G,G */ - 200 280 150 280 /* GU,AU,G,G,U */ - 210 290 160 290 /* GU,AU,G,U,A */ - 270 290 160 290 /* GU,AU,G,U,C */ - 210 290 160 290 /* GU,AU,G,U,G */ - 120 200 200 200 /* GU,AU,G,U,U */ - 310 310 310 370 /* GU,AU,U,A,A */ - 280 280 280 280 /* GU,AU,U,A,C */ - 180 240 180 180 /* GU,AU,U,A,G */ - 280 280 280 280 /* GU,AU,U,A,U */ - 290 290 290 290 /* GU,AU,U,C,A */ - 290 290 290 290 /* GU,AU,U,C,C */ - 290 290 290 290 /* GU,AU,U,C,G */ - 290 290 290 290 /* GU,AU,U,C,U */ - 250 310 250 250 /* GU,AU,U,G,A */ - 280 280 280 280 /* GU,AU,U,G,C */ - 130 130 130 260 /* GU,AU,U,G,G */ - 280 280 280 280 /* GU,AU,U,G,U */ - 290 290 290 290 /* GU,AU,U,U,A */ - 290 290 290 290 /* GU,AU,U,U,C */ - 290 290 290 290 /* GU,AU,U,U,G */ - 200 200 200 200 /* GU,AU,U,U,U */ - 340 310 270 310 /* GU,UA,A,A,A */ - 300 260 220 260 /* GU,UA,A,A,C */ - 240 200 160 200 /* GU,UA,A,A,G */ - 300 260 220 260 /* GU,UA,A,A,U */ - 340 310 270 310 /* GU,UA,A,C,A */ - 340 310 330 310 /* GU,UA,A,C,C */ - 340 310 270 310 /* GU,UA,A,C,G */ - 340 310 330 310 /* GU,UA,A,C,U */ - 250 210 170 210 /* GU,UA,A,G,A */ - 300 260 220 260 /* GU,UA,A,G,C */ - 190 150 240 150 /* GU,UA,A,G,G */ - 300 260 220 260 /* GU,UA,A,G,U */ - 340 310 270 310 /* GU,UA,A,U,A */ - 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170 280 120 280 /* UA,UG,G,G,C */ - 170 150 250 150 /* UA,UG,G,G,G */ - 170 280 120 280 /* UA,UG,G,G,U */ - 170 280 120 280 /* UA,UG,G,U,A */ - 230 280 120 280 /* UA,UG,G,U,C */ - 170 280 120 280 /* UA,UG,G,U,G */ - 170 280 250 280 /* UA,UG,G,U,U */ - 200 240 200 220 /* UA,UG,U,A,A */ - 230 280 230 190 /* UA,UG,U,A,C */ - 100 200 100 60 /* UA,UG,U,A,G */ - 230 280 230 190 /* UA,UG,U,A,U */ - 230 280 230 190 /* UA,UG,U,C,A */ - 230 280 230 190 /* UA,UG,U,C,C */ - 230 280 230 190 /* UA,UG,U,C,G */ - 230 280 230 190 /* UA,UG,U,C,U */ - 260 370 260 220 /* UA,UG,U,G,A */ - 230 280 230 190 /* UA,UG,U,G,C */ - 100 150 100 190 /* UA,UG,U,G,G */ - 230 280 230 190 /* UA,UG,U,G,U */ - 230 280 230 190 /* UA,UG,U,U,A */ - 230 280 230 190 /* UA,UG,U,U,C */ - 230 280 230 190 /* UA,UG,U,U,G */ - 230 280 230 190 /* UA,UG,U,U,U */ - 280 280 180 280 /* UA,AU,A,A,A */ - 250 250 160 250 /* UA,AU,A,A,C */ - 150 150 60 150 /* UA,AU,A,A,G */ - 250 250 160 250 /* UA,AU,A,A,U */ - 260 260 170 260 /* UA,AU,A,C,A */ - 260 260 220 260 /* UA,AU,A,C,C */ - 260 260 170 260 /* UA,AU,A,C,G */ - 260 260 220 260 /* UA,AU,A,C,U */ - 220 220 130 220 /* UA,AU,A,G,A */ - 250 250 160 250 /* UA,AU,A,G,C */ - 100 100 140 100 /* UA,AU,A,G,G */ - 250 250 160 250 /* UA,AU,A,G,U */ - 260 260 170 260 /* UA,AU,A,U,A */ - 260 260 220 260 /* UA,AU,A,U,C */ - 260 260 170 260 /* UA,AU,A,U,G */ - 230 170 70 170 /* UA,AU,A,U,U */ - 230 280 230 250 /* UA,AU,C,A,A */ - 210 250 210 220 /* UA,AU,C,A,C */ - 110 210 110 180 /* UA,AU,C,A,G */ - 210 250 210 220 /* UA,AU,C,A,U */ - 220 260 220 230 /* UA,AU,C,C,A */ - 210 260 210 230 /* UA,AU,C,C,C */ - 220 260 220 230 /* UA,AU,C,C,G */ - 210 260 210 230 /* UA,AU,C,C,U */ - 180 280 180 250 /* UA,AU,C,G,A */ - 210 250 210 220 /* UA,AU,C,G,C */ - 60 100 60 70 /* UA,AU,C,G,G */ - 210 250 210 220 /* UA,AU,C,G,U */ - 220 260 220 230 /* UA,AU,C,U,A */ - 210 260 210 230 /* UA,AU,C,U,C */ - 220 260 220 230 /* UA,AU,C,U,G */ - 120 170 120 140 /* UA,AU,C,U,U */ - 170 280 120 280 /* UA,AU,G,A,A */ - 150 250 100 250 /* UA,AU,G,A,C */ - 50 150 130 150 /* UA,AU,G,A,G */ - 150 250 100 250 /* UA,AU,G,A,U */ - 160 260 110 260 /* UA,AU,G,C,A */ - 210 260 100 260 /* UA,AU,G,C,C */ - 160 260 110 260 /* UA,AU,G,C,G */ - 210 260 100 260 /* UA,AU,G,C,U */ - 120 220 200 220 /* UA,AU,G,G,A */ - 150 250 100 250 /* UA,AU,G,G,C */ - 130 100 210 100 /* UA,AU,G,G,G */ - 150 250 100 250 /* UA,AU,G,G,U */ - 160 260 110 260 /* UA,AU,G,U,A */ - 210 260 100 260 /* UA,AU,G,U,C */ - 160 260 110 260 /* UA,AU,G,U,G */ - 60 170 140 170 /* UA,AU,G,U,U */ - 230 280 230 250 /* UA,AU,U,A,A */ - 210 250 210 170 /* UA,AU,U,A,C */ - 110 210 110 70 /* UA,AU,U,A,G */ - 210 250 210 170 /* UA,AU,U,A,U */ - 220 260 220 180 /* UA,AU,U,C,A */ - 210 260 210 170 /* UA,AU,U,C,C */ - 220 260 220 180 /* UA,AU,U,C,G */ - 210 260 210 170 /* UA,AU,U,C,U */ - 180 280 180 140 /* UA,AU,U,G,A */ - 210 250 210 170 /* UA,AU,U,G,C */ - 60 100 60 150 /* UA,AU,U,G,G */ - 210 250 210 170 /* UA,AU,U,G,U */ - 220 260 220 180 /* UA,AU,U,U,A */ - 210 260 210 170 /* UA,AU,U,U,C */ - 220 260 220 180 /* UA,AU,U,U,G */ - 120 170 120 80 /* UA,AU,U,U,U */ - 280 280 180 280 /* UA,UA,A,A,A */ - 230 230 140 230 /* UA,UA,A,A,C */ - 170 170 80 170 /* UA,UA,A,A,G */ - 230 230 140 230 /* UA,UA,A,A,U */ - 280 280 180 280 /* UA,UA,A,C,A */ - 280 280 240 280 /* UA,UA,A,C,C */ - 280 280 180 280 /* UA,UA,A,C,G */ - 280 280 240 280 /* UA,UA,A,C,U */ - 180 180 90 180 /* UA,UA,A,G,A */ - 230 230 140 230 /* UA,UA,A,G,C */ - 120 120 160 120 /* UA,UA,A,G,G */ - 230 230 140 230 /* UA,UA,A,G,U */ - 280 280 180 280 /* UA,UA,A,U,A */ - 250 250 210 250 /* UA,UA,A,U,C */ - 280 280 180 280 /* UA,UA,A,U,G */ - 250 190 100 190 /* UA,UA,A,U,U */ - 230 280 230 250 /* UA,UA,C,A,A */ - 190 230 190 200 /* UA,UA,C,A,C */ - 130 230 130 200 /* UA,UA,C,A,G */ - 190 230 190 200 /* UA,UA,C,A,U */ - 230 280 230 250 /* UA,UA,C,C,A */ - 230 280 230 250 /* UA,UA,C,C,C */ - 230 280 230 250 /* UA,UA,C,C,G */ - 230 280 230 250 /* UA,UA,C,C,U */ - 140 240 140 210 /* UA,UA,C,G,A */ - 190 230 190 200 /* UA,UA,C,G,C */ - 80 120 80 90 /* UA,UA,C,G,G */ - 190 230 190 200 /* UA,UA,C,G,U */ - 230 280 230 250 /* UA,UA,C,U,A */ - 200 250 200 220 /* UA,UA,C,U,C */ - 230 280 230 250 /* UA,UA,C,U,G */ - 150 190 150 160 /* UA,UA,C,U,U */ - 170 280 120 280 /* UA,UA,G,A,A */ - 130 230 80 230 /* UA,UA,G,A,C */ - 70 170 150 170 /* UA,UA,G,A,G */ - 130 230 80 230 /* UA,UA,G,A,U */ - 170 280 120 280 /* UA,UA,G,C,A */ - 230 280 120 280 /* UA,UA,G,C,C */ - 170 280 120 280 /* UA,UA,G,C,G */ - 230 280 120 280 /* UA,UA,G,C,U */ - 80 180 160 180 /* UA,UA,G,G,A */ - 130 230 80 230 /* UA,UA,G,G,C */ - 150 120 230 120 /* UA,UA,G,G,G */ - 130 230 80 230 /* UA,UA,G,G,U */ - 170 280 120 280 /* UA,UA,G,U,A */ - 200 250 90 250 /* UA,UA,G,U,C */ - 170 280 120 280 /* UA,UA,G,U,G */ - 90 190 170 190 /* UA,UA,G,U,U */ - 230 280 230 250 /* UA,UA,U,A,A */ - 190 230 190 150 /* UA,UA,U,A,C */ - 130 230 130 90 /* UA,UA,U,A,G */ - 190 230 190 150 /* UA,UA,U,A,U */ - 230 280 230 190 /* UA,UA,U,C,A */ - 230 280 230 190 /* UA,UA,U,C,C */ - 230 280 230 190 /* UA,UA,U,C,G */ - 230 280 230 190 /* UA,UA,U,C,U */ - 140 240 140 100 /* UA,UA,U,G,A */ - 190 230 190 150 /* UA,UA,U,G,C */ - 80 120 80 170 /* UA,UA,U,G,G */ - 190 230 190 150 /* UA,UA,U,G,U */ - 230 280 230 190 /* UA,UA,U,U,A */ - 200 250 200 160 /* UA,UA,U,U,C */ - 230 280 230 190 /* UA,UA,U,U,G */ - 150 190 150 110 /* UA,UA,U,U,U */ - -# int22_enthalpies - -460 -310 -960 -310 /* CG,CG,A,A,A */ - -770 -620 -1270 -620 /* CG,CG,A,A,C */ - -670 -530 -1170 -530 /* CG,CG,A,A,G */ - -770 -620 -1270 -620 /* CG,CG,A,A,U */ - -310 -170 -810 -170 /* CG,CG,A,C,A */ - -320 -170 -580 -170 /* CG,CG,A,C,C */ - -310 -170 -810 -170 /* CG,CG,A,C,G */ - -370 -220 -630 -220 /* CG,CG,A,C,U */ - -960 -810 -1460 -810 /* CG,CG,A,G,A */ - -770 -620 -1270 -620 /* CG,CG,A,G,C */ - -120 30 -1870 30 /* CG,CG,A,G,G */ - -770 -620 -1270 -620 /* CG,CG,A,G,U */ - -310 -170 -810 -170 /* CG,CG,A,U,A */ - -260 -110 -520 -110 /* CG,CG,A,U,C */ - -310 -170 -810 -170 /* CG,CG,A,U,G */ - -860 -960 -1600 -960 /* CG,CG,A,U,U */ - -770 -320 -770 -260 /* CG,CG,C,A,A */ - -1080 -630 -1080 -570 /* CG,CG,C,A,C */ - -980 -290 -980 -230 /* CG,CG,C,A,G */ - -1080 -630 -1080 -570 /* CG,CG,C,A,U */ - -620 -170 -620 -110 /* CG,CG,C,C,A */ - -630 -180 -630 -120 /* CG,CG,C,C,C */ - -620 -170 -620 -110 /* CG,CG,C,C,G */ - -680 -230 -680 -170 /* CG,CG,C,C,U */ - -1270 -580 -1270 -520 /* CG,CG,C,G,A */ - -1080 -630 -1080 -570 /* CG,CG,C,G,C */ - -430 20 -430 80 /* CG,CG,C,G,G */ - -1080 -630 -1080 -570 /* CG,CG,C,G,U */ - -620 -170 -620 -110 /* CG,CG,C,U,A */ - -570 -120 -570 -60 /* CG,CG,C,U,C */ - -620 -170 -620 -110 /* CG,CG,C,U,G */ - -1410 -960 -1410 -900 /* CG,CG,C,U,U */ - -670 -310 -120 -310 /* CG,CG,G,A,A */ - -980 -620 -430 -620 /* CG,CG,G,A,C */ - -890 -530 -1580 -530 /* CG,CG,G,A,G */ - -980 -620 -430 -620 /* CG,CG,G,A,U */ - -530 -170 30 -170 /* CG,CG,G,C,A */ - -290 -170 20 -170 /* CG,CG,G,C,C */ - -530 -170 30 -170 /* CG,CG,G,C,G */ - -340 -220 -30 -220 /* CG,CG,G,C,U */ - -1170 -810 -1870 -810 /* CG,CG,G,G,A */ - -980 -620 -430 -620 /* CG,CG,G,G,C */ - -1580 30 -2280 30 /* CG,CG,G,G,G */ - -980 -620 -430 -620 /* CG,CG,G,G,U */ - -530 -170 30 -170 /* CG,CG,G,U,A */ - -230 -110 80 -110 /* CG,CG,G,U,C */ - -530 -170 30 -170 /* CG,CG,G,U,G */ - -1320 -960 -2010 -960 /* CG,CG,G,U,U */ - -770 -370 -770 -860 /* CG,CG,U,A,A */ - -1080 -680 -1080 -1410 /* CG,CG,U,A,C */ - -980 -340 -980 -1320 /* CG,CG,U,A,G */ - -1080 -680 -1080 -1410 /* CG,CG,U,A,U */ - -620 -220 -620 -960 /* CG,CG,U,C,A */ - -630 -230 -630 -960 /* CG,CG,U,C,C */ - -620 -220 -620 -960 /* CG,CG,U,C,G */ - -680 -280 -680 -1010 /* CG,CG,U,C,U */ - -1270 -630 -1270 -1600 /* CG,CG,U,G,A */ - -1080 -680 -1080 -1410 /* CG,CG,U,G,C */ - -430 -30 -430 -2010 /* CG,CG,U,G,G */ - -1080 -680 -1080 -1410 /* CG,CG,U,G,U */ - -620 -220 -620 -960 /* CG,CG,U,U,A */ - -570 -170 -570 -900 /* CG,CG,U,U,C */ - -620 -220 -620 -960 /* CG,CG,U,U,G */ - -1410 -1010 -1410 -1750 /* CG,CG,U,U,U */ - -580 -220 -970 -150 /* CG,GC,A,A,A */ - -740 -600 -100 -600 /* CG,GC,A,A,C */ - -2010 -1650 -1980 -1340 /* CG,GC,A,A,G */ - -740 -600 -1240 -600 /* CG,GC,A,A,U */ - -660 -1150 10 -510 /* CG,GC,A,C,A */ - -960 -820 540 -820 /* CG,GC,A,C,C */ - -660 -510 -1160 -510 /* CG,GC,A,C,G */ - -960 -820 -1220 -820 /* CG,GC,A,C,U */ - -1340 -860 -2450 -860 /* CG,GC,A,G,A */ - -740 -600 -1240 -600 /* CG,GC,A,G,C */ - 180 -390 -1870 30 /* CG,GC,A,G,G */ - -740 -600 -1240 -600 /* CG,GC,A,G,U */ - -660 -510 -1160 -510 /* CG,GC,A,U,A */ - -1270 -1130 -1530 -1130 /* CG,GC,A,U,C */ - -660 -510 -1160 -510 /* CG,GC,A,U,G */ - -1240 -90 -810 -800 /* CG,GC,A,U,U */ - -600 -1070 -600 -90 /* CG,GC,C,A,A */ - -1050 -600 -1050 -540 /* CG,GC,C,A,C */ - -1790 -630 -1790 -1040 /* CG,GC,C,A,G */ - -1050 -600 -1050 -540 /* CG,GC,C,A,U */ - -970 -750 -970 -460 /* CG,GC,C,C,A */ - -1270 -820 -1270 -760 /* CG,GC,C,C,C */ - -970 -520 -970 -460 /* CG,GC,C,C,G */ - -1270 -820 -1270 -550 /* CG,GC,C,C,U */ - -1070 -500 -1320 -570 /* CG,GC,C,G,A */ - -1050 -600 -1050 -540 /* CG,GC,C,G,C */ - -430 20 -430 180 /* CG,GC,C,G,G */ - -1050 -600 -1050 -540 /* CG,GC,C,G,U */ - -970 -520 -970 -460 /* CG,GC,C,U,A */ - -1580 -1130 -1580 -1070 /* CG,GC,C,U,C */ - -970 -520 -970 -460 /* CG,GC,C,U,G */ - -830 -1710 -1260 -1460 /* CG,GC,C,U,U */ - -1600 -150 -200 -150 /* CG,GC,G,A,A */ - -350 -600 -440 -600 /* CG,GC,G,A,C */ - -3070 -1340 -2390 -1340 /* CG,GC,G,A,G */ - -960 -600 -400 -600 /* CG,GC,G,A,U */ - -1110 -510 -320 -510 /* CG,GC,G,C,A */ - -940 -820 -620 -820 /* CG,GC,G,C,C */ - -870 -510 -320 -510 /* CG,GC,G,C,G */ - -940 -820 -260 -820 /* CG,GC,G,C,U */ - -1880 -860 -1080 -860 /* CG,GC,G,G,A */ - -960 -600 -400 -600 /* CG,GC,G,G,C */ - -1370 30 -2280 30 /* CG,GC,G,G,G */ - -960 -600 -400 -600 /* CG,GC,G,G,U */ - -870 -510 -320 -510 /* CG,GC,G,U,A */ - -1250 -1130 -210 -1130 /* CG,GC,G,U,C */ - -870 -510 -320 -510 /* CG,GC,G,U,G */ - -1360 -800 -1550 -800 /* CG,GC,G,U,U */ - -600 -200 -600 -1490 /* CG,GC,U,A,A */ - -1050 -650 -1050 -1390 /* CG,GC,U,A,C */ - -1790 -1150 -1790 -1520 /* CG,GC,U,A,G */ - -1050 -650 -1050 -1390 /* CG,GC,U,A,U */ - -970 -570 -970 -400 /* CG,GC,U,C,A */ - -1270 -870 -1270 -1610 /* CG,GC,U,C,C */ - -970 -570 -970 -1300 /* CG,GC,U,C,G */ - -1270 -870 -1270 -1610 /* CG,GC,U,C,U */ - -1320 -1750 -1320 -1300 /* CG,GC,U,G,A */ - -1050 -650 -1050 -1390 /* CG,GC,U,G,C */ - -430 -880 -430 -230 /* CG,GC,U,G,G */ - -1050 -650 -1050 -1390 /* CG,GC,U,G,U */ - -970 -570 -970 -1300 /* CG,GC,U,U,A */ - -1580 -1180 -1580 -1920 /* CG,GC,U,U,C */ - -970 -570 -970 -1300 /* CG,GC,U,U,G */ - -1260 -860 -1260 -2350 /* CG,GC,U,U,U */ - -1370 -1240 -1890 -1240 /* CG,GU,A,A,A */ - -1210 -1060 -1710 -1060 /* CG,GU,A,A,C */ - -1220 -1080 -1720 -1080 /* CG,GU,A,A,G */ - -1210 -1060 -1710 -1060 /* CG,GU,A,A,U */ - -1210 -1060 -1710 -1060 /* CG,GU,A,C,A */ - -1210 -1060 -1470 -1060 /* CG,GU,A,C,C */ - -1210 -1060 -1710 -1060 /* CG,GU,A,C,G */ - -1210 -1060 -1470 -1060 /* CG,GU,A,C,U */ - -1030 -890 -1530 -890 /* CG,GU,A,G,A */ - -1210 -1060 -1710 -1060 /* CG,GU,A,G,C */ - 40 190 -1710 190 /* CG,GU,A,G,G */ - -1210 -1060 -1710 -1060 /* CG,GU,A,G,U */ - -1210 -1060 -1710 -1060 /* CG,GU,A,U,A */ - -1210 -1060 -1470 -1060 /* CG,GU,A,U,C */ - -1210 -1060 -1710 -1060 /* CG,GU,A,U,G */ - -970 -1060 -1710 -1060 /* CG,GU,A,U,U */ - -1700 -1250 -1700 -1190 /* CG,GU,C,A,A */ - -1520 -1070 -1520 -1010 /* CG,GU,C,A,C */ - -1530 -840 -1530 -780 /* CG,GU,C,A,G */ - -1520 -1070 -1520 -1010 /* CG,GU,C,A,U */ - -1520 -1070 -1520 -1010 /* CG,GU,C,C,A */ - -1520 -1070 -1520 -1010 /* CG,GU,C,C,C */ - -1520 -1070 -1520 -1010 /* CG,GU,C,C,G */ - -1520 -1070 -1520 -1010 /* CG,GU,C,C,U */ - -1340 -650 -1340 -590 /* CG,GU,C,G,A */ - -1520 -1070 -1520 -1010 /* CG,GU,C,G,C */ - -270 180 -270 240 /* CG,GU,C,G,G */ - -1520 -1070 -1520 -1010 /* CG,GU,C,G,U */ - -1520 -1070 -1520 -1010 /* CG,GU,C,U,A */ - -1520 -1070 -1520 -1010 /* CG,GU,C,U,C */ - -1520 -1070 -1520 -1010 /* CG,GU,C,U,G */ - -1520 -1070 -1520 -1010 /* CG,GU,C,U,U */ - -1600 -1240 -1050 -1240 /* CG,GU,G,A,A */ - -1420 -1060 -870 -1060 /* CG,GU,G,A,C */ - -1440 -1080 -2130 -1080 /* CG,GU,G,A,G */ - -1420 -1060 -870 -1060 /* CG,GU,G,A,U */ - -1420 -1060 -870 -1060 /* CG,GU,G,C,A */ - -1180 -1060 -870 -1060 /* CG,GU,G,C,C */ - -1420 -1060 -870 -1060 /* CG,GU,G,C,G */ - -1180 -1060 -870 -1060 /* CG,GU,G,C,U */ - -1250 -890 -1940 -890 /* CG,GU,G,G,A */ - -1420 -1060 -870 -1060 /* CG,GU,G,G,C */ - -1420 190 -2120 190 /* CG,GU,G,G,G */ - -1420 -1060 -870 -1060 /* CG,GU,G,G,U */ - -1420 -1060 -870 -1060 /* CG,GU,G,U,A */ - -1180 -1060 -870 -1060 /* CG,GU,G,U,C */ - -1420 -1060 -870 -1060 /* CG,GU,G,U,G */ - -1420 -1060 -2120 -1060 /* CG,GU,G,U,U */ - -1700 -1300 -1700 -1790 /* CG,GU,U,A,A */ - -1520 -1120 -1520 -1850 /* CG,GU,U,A,C */ - -1530 -890 -1530 -1870 /* CG,GU,U,A,G */ - -1520 -1120 -1520 -1850 /* CG,GU,U,A,U */ - -1520 -1120 -1520 -1850 /* CG,GU,U,C,A */ - -1520 -1120 -1520 -1850 /* CG,GU,U,C,C */ - -1520 -1120 -1520 -1850 /* CG,GU,U,C,G */ - -1520 -1120 -1520 -1850 /* CG,GU,U,C,U */ - -1340 -700 -1340 -1680 /* CG,GU,U,G,A */ - -1520 -1120 -1520 -1850 /* CG,GU,U,G,C */ - -270 130 -270 -1850 /* CG,GU,U,G,G */ - -1520 -1120 -1520 -1850 /* CG,GU,U,G,U */ - -1520 -1120 -1520 -1850 /* CG,GU,U,U,A */ - -1520 -1120 -1520 -1850 /* CG,GU,U,U,C */ - -1520 -1120 -1520 -1850 /* CG,GU,U,U,G */ - -1520 -1120 -1520 -1850 /* CG,GU,U,U,U */ - -140 0 -640 0 /* CG,UG,A,A,A */ - -650 -510 -1150 -510 /* CG,UG,A,A,C */ - -990 -850 -1490 -850 /* CG,UG,A,A,G */ - -650 -510 -1150 -510 /* CG,UG,A,A,U */ - -650 -510 -1150 -510 /* CG,UG,A,C,A */ - -650 -510 -910 -510 /* CG,UG,A,C,C */ - -650 -510 -1150 -510 /* CG,UG,A,C,G */ - -650 -510 -910 -510 /* CG,UG,A,C,U */ - -1160 -1020 -1660 -1020 /* CG,UG,A,G,A */ - -650 -510 -1150 -510 /* CG,UG,A,G,C */ - 600 740 -1150 740 /* CG,UG,A,G,G */ - -650 -510 -1150 -510 /* CG,UG,A,G,U */ - -650 -510 -1150 -510 /* CG,UG,A,U,A */ - -650 -510 -910 -510 /* CG,UG,A,U,C */ - -650 -510 -1150 -510 /* CG,UG,A,U,G */ - -410 -510 -1150 -510 /* CG,UG,A,U,U */ - -450 0 -450 50 /* CG,UG,C,A,A */ - -960 -510 -960 -450 /* CG,UG,C,A,C */ - -1300 -610 -1300 -550 /* CG,UG,C,A,G */ - -960 -510 -960 -450 /* CG,UG,C,A,U */ - -960 -510 -960 -450 /* CG,UG,C,C,A */ - -960 -510 -960 -450 /* CG,UG,C,C,C */ - -960 -510 -960 -450 /* CG,UG,C,C,G */ - -960 -510 -960 -450 /* CG,UG,C,C,U */ - -1470 -780 -1470 -720 /* CG,UG,C,G,A */ - -960 -510 -960 -450 /* CG,UG,C,G,C */ - 290 740 290 800 /* CG,UG,C,G,G */ - -960 -510 -960 -450 /* CG,UG,C,G,U */ - -960 -510 -960 -450 /* CG,UG,C,U,A */ - -960 -510 -960 -450 /* CG,UG,C,U,C */ - -960 -510 -960 -450 /* CG,UG,C,U,G */ - -960 -510 -960 -450 /* CG,UG,C,U,U */ - -360 0 200 0 /* CG,UG,G,A,A */ - -870 -510 -310 -510 /* CG,UG,G,A,C */ - -1210 -850 -1900 -850 /* CG,UG,G,A,G */ - -870 -510 -310 -510 /* CG,UG,G,A,U */ - -870 -510 -310 -510 /* CG,UG,G,C,A */ - -630 -510 -310 -510 /* CG,UG,G,C,C */ - -870 -510 -310 -510 /* CG,UG,G,C,G */ - -630 -510 -310 -510 /* CG,UG,G,C,U */ - -1380 -1020 -2070 -1020 /* CG,UG,G,G,A */ - -870 -510 -310 -510 /* CG,UG,G,G,C */ - -870 740 -1560 740 /* CG,UG,G,G,G */ - -870 -510 -310 -510 /* CG,UG,G,G,U */ - -870 -510 -310 -510 /* CG,UG,G,U,A */ - -630 -510 -310 -510 /* CG,UG,G,U,C */ - 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-250 -850 -1200 -850 /* GC,UG,A,U,U */ - -430 -650 -430 -960 /* GC,UG,C,A,A */ - -940 -1160 -940 -1470 /* GC,UG,C,A,C */ - -1280 -1260 -1280 -1570 /* GC,UG,C,A,G */ - -940 -1160 -940 -1470 /* GC,UG,C,A,U */ - -940 -1160 -940 -1470 /* GC,UG,C,C,A */ - -940 -1160 -940 -1470 /* GC,UG,C,C,C */ - -940 -1160 -940 -1470 /* GC,UG,C,C,G */ - -940 -1160 -940 -1470 /* GC,UG,C,C,U */ - -1450 -1430 -1450 -1740 /* GC,UG,C,G,A */ - -940 -1160 -940 -1470 /* GC,UG,C,G,C */ - 310 90 310 -220 /* GC,UG,C,G,G */ - -940 -1160 -940 -1470 /* GC,UG,C,G,U */ - -940 -1160 -940 -1470 /* GC,UG,C,U,A */ - -940 -1160 -940 -1470 /* GC,UG,C,U,C */ - -940 -1160 -940 -1470 /* GC,UG,C,U,G */ - -940 -1160 -940 -1470 /* GC,UG,C,U,U */ - -1170 -340 200 -340 /* GC,UG,G,A,A */ - -1680 -850 -310 -850 /* GC,UG,G,A,C */ - -2020 -1190 -1900 -1190 /* GC,UG,G,A,G */ - -1680 -850 -310 -850 /* GC,UG,G,A,U */ - -1680 -850 -310 -850 /* GC,UG,G,C,A */ - -1440 -850 -310 -850 /* GC,UG,G,C,C */ - -1680 -850 -310 -850 /* GC,UG,G,C,G */ - -1440 -850 -310 -850 /* GC,UG,G,C,U */ - 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600 240 -110 240 /* GC,AU,A,A,A */ - 290 -70 -420 -70 /* GC,AU,A,A,C */ - -780 -1150 -1500 -1150 /* GC,AU,A,A,G */ - 290 -70 -420 -70 /* GC,AU,A,A,U */ - 310 -50 -400 -50 /* GC,AU,A,C,A */ - 300 -60 -170 -60 /* GC,AU,A,C,C */ - 310 -50 -400 -50 /* GC,AU,A,C,G */ - 300 -60 -170 -60 /* GC,AU,A,C,U */ - -600 -970 -1320 -970 /* GC,AU,A,G,A */ - 290 -70 -420 -70 /* GC,AU,A,G,C */ - 1140 770 -830 770 /* GC,AU,A,G,G */ - 290 -70 -420 -70 /* GC,AU,A,G,U */ - 310 -50 -400 -50 /* GC,AU,A,U,A */ - 300 -60 -170 -60 /* GC,AU,A,U,C */ - 310 -50 -400 -50 /* GC,AU,A,U,G */ - -430 -1040 -1390 -1040 /* GC,AU,A,U,U */ - 150 -60 150 -370 /* GC,AU,C,A,A */ - -150 -370 -150 -680 /* GC,AU,C,A,C */ - -1230 -1210 -1230 -1520 /* GC,AU,C,A,G */ - -150 -370 -150 -680 /* GC,AU,C,A,U */ - -140 -360 -140 -670 /* GC,AU,C,C,A */ - -140 -360 -140 -670 /* GC,AU,C,C,C */ - -140 -360 -140 -670 /* GC,AU,C,C,G */ - -140 -360 -140 -670 /* GC,AU,C,C,U */ - -1050 -1030 -1050 -1340 /* GC,AU,C,G,A */ - -150 -370 -150 -680 /* GC,AU,C,G,C */ - 690 470 690 160 /* GC,AU,C,G,G */ - -150 -370 -150 -680 /* GC,AU,C,G,U */ - -140 -360 -140 -670 /* GC,AU,C,U,A */ - -140 -360 -140 -670 /* GC,AU,C,U,C */ - -140 -360 -140 -670 /* GC,AU,C,U,G */ - -1120 -1340 -1120 -1650 /* GC,AU,C,U,U */ - -580 240 780 240 /* GC,AU,G,A,A */ - -890 -70 470 -70 /* GC,AU,G,A,C */ - -1970 -1150 -1860 -1150 /* GC,AU,G,A,G */ - -890 -70 470 -70 /* GC,AU,G,A,U */ - -880 -50 490 -50 /* GC,AU,G,C,A */ - -640 -60 480 -60 /* GC,AU,G,C,C */ - -880 -50 490 -50 /* GC,AU,G,C,G */ - -640 -60 480 -60 /* GC,AU,G,C,U */ - -1790 -970 -1680 -970 /* GC,AU,G,G,A */ - -890 -70 470 -70 /* GC,AU,G,G,C */ - -1300 770 -1190 770 /* GC,AU,G,G,G */ - -890 -70 470 -70 /* GC,AU,G,G,U */ - -880 -50 490 -50 /* GC,AU,G,U,A */ - -640 -60 480 -60 /* GC,AU,G,U,C */ - -880 -50 490 -50 /* GC,AU,G,U,G */ - -1860 -1040 -1750 -1040 /* GC,AU,G,U,U */ - 150 -60 150 190 /* GC,AU,U,A,A */ - -150 -370 -150 -360 /* GC,AU,U,A,C */ - -1230 -1210 -1230 -1440 /* GC,AU,U,A,G */ - -150 -370 -150 -360 /* GC,AU,U,A,U */ - -140 -360 -140 -340 /* GC,AU,U,C,A */ - -140 -360 -140 -350 /* GC,AU,U,C,C */ - -140 -360 -140 -340 /* GC,AU,U,C,G */ - -140 -360 -140 -350 /* GC,AU,U,C,U */ - -1050 -1030 -1050 -1260 /* GC,AU,U,G,A */ - -150 -370 -150 -360 /* GC,AU,U,G,C */ - 690 470 690 -770 /* GC,AU,U,G,G */ - -150 -370 -150 -360 /* GC,AU,U,G,U */ - -140 -360 -140 -340 /* GC,AU,U,U,A */ - -140 -360 -140 -350 /* GC,AU,U,U,C */ - -140 -360 -140 -340 /* GC,AU,U,U,G */ - -1120 -1340 -1120 -1330 /* GC,AU,U,U,U */ - 670 300 -40 300 /* GC,UA,A,A,A */ - 390 20 -320 20 /* GC,UA,A,A,C */ - -730 -1100 -1450 -1100 /* GC,UA,A,A,G */ - 390 20 -320 20 /* GC,UA,A,A,U */ - 540 170 -170 170 /* GC,UA,A,C,A */ - 540 170 70 170 /* GC,UA,A,C,C */ - 540 170 -170 170 /* GC,UA,A,C,G */ - 410 40 -60 40 /* GC,UA,A,C,U */ - -1030 -1400 -1750 -1400 /* GC,UA,A,G,A */ - 390 20 -320 20 /* GC,UA,A,G,C */ - 1320 960 -640 960 /* GC,UA,A,G,G */ - 390 20 -320 20 /* GC,UA,A,G,U */ - 540 170 -170 170 /* GC,UA,A,U,A */ - 100 -260 -370 -260 /* GC,UA,A,U,C */ - 540 170 -170 170 /* GC,UA,A,U,G */ - -160 -760 -1110 -760 /* GC,UA,A,U,U */ - 220 0 220 -310 /* GC,UA,C,A,A */ - -60 -280 -60 -590 /* GC,UA,C,A,C */ - -1180 -1160 -1180 -1470 /* GC,UA,C,A,G */ - -60 -280 -60 -590 /* GC,UA,C,A,U */ - 90 -130 90 -440 /* GC,UA,C,C,A */ - 90 -130 90 -440 /* GC,UA,C,C,C */ - 90 -130 90 -440 /* GC,UA,C,C,G */ - -40 -260 -40 -570 /* GC,UA,C,C,U */ - -1480 -1460 -1480 -1770 /* GC,UA,C,G,A */ - -60 -280 -60 -590 /* GC,UA,C,G,C */ - 870 650 870 340 /* GC,UA,C,G,G */ - -60 -280 -60 -590 /* GC,UA,C,G,U */ - 90 -130 90 -440 /* GC,UA,C,U,A */ - -350 -570 -350 -880 /* GC,UA,C,U,C */ - 90 -130 90 -440 /* GC,UA,C,U,G */ - -850 -1070 -850 -1380 /* GC,UA,C,U,U */ - -520 300 850 300 /* GC,UA,G,A,A */ - -800 20 570 20 /* GC,UA,G,A,C */ - -1920 -1100 -1810 -1100 /* GC,UA,G,A,G */ - -800 20 570 20 /* GC,UA,G,A,U */ - -650 170 720 170 /* GC,UA,G,C,A */ - -410 170 720 170 /* GC,UA,G,C,C */ - -650 170 720 170 /* GC,UA,G,C,G */ - -540 40 590 40 /* GC,UA,G,C,U */ - -2220 -1400 -2110 -1400 /* GC,UA,G,G,A */ - -800 20 570 20 /* GC,UA,G,G,C */ - -1120 960 -1000 960 /* GC,UA,G,G,G */ - -800 20 570 20 /* GC,UA,G,G,U */ - -650 170 720 170 /* GC,UA,G,U,A */ - -850 -260 280 -260 /* GC,UA,G,U,C */ - -650 170 720 170 /* GC,UA,G,U,G */ - -1590 -760 -1470 -760 /* GC,UA,G,U,U */ - 220 0 220 250 /* GC,UA,U,A,A */ - -60 -280 -60 -260 /* GC,UA,U,A,C */ - -1180 -1160 -1180 -1390 /* GC,UA,U,A,G */ - -60 -280 -60 -260 /* GC,UA,U,A,U */ - 90 -130 90 -110 /* GC,UA,U,C,A */ - 90 -130 90 -110 /* GC,UA,U,C,C */ - 90 -130 90 -110 /* GC,UA,U,C,G */ - -40 -260 -40 -240 /* GC,UA,U,C,U */ - -1480 -1460 -1480 -1690 /* GC,UA,U,G,A */ - -60 -280 -60 -260 /* GC,UA,U,G,C */ - 870 650 870 -580 /* GC,UA,U,G,G */ - -60 -280 -60 -260 /* GC,UA,U,G,U */ - 90 -130 90 -110 /* GC,UA,U,U,A */ - -350 -570 -350 -550 /* GC,UA,U,U,C */ - 90 -130 90 -110 /* GC,UA,U,U,G */ - -850 -1070 -850 -1050 /* GC,UA,U,U,U */ - -1370 -1210 -1030 -1210 /* GU,CG,A,A,A */ - -1700 -1520 -1340 -1520 /* GU,CG,A,A,C */ - -1600 -1420 -1250 -1420 /* GU,CG,A,A,G */ - 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-870 -870 -870 -870 /* GU,CG,C,G,G */ - -1520 -1520 -1520 -1520 /* GU,CG,C,G,U */ - -1060 -1060 -1060 -1060 /* GU,CG,C,U,A */ - -1010 -1010 -1010 -1010 /* GU,CG,C,U,C */ - -1060 -1060 -1060 -1060 /* GU,CG,C,U,G */ - -1850 -1850 -1850 -1850 /* GU,CG,C,U,U */ - -1220 -1210 40 -1210 /* GU,CG,G,A,A */ - -1530 -1520 -270 -1520 /* GU,CG,G,A,C */ - -1440 -1420 -1420 -1420 /* GU,CG,G,A,G */ - -1530 -1520 -270 -1520 /* GU,CG,G,A,U */ - -1080 -1060 190 -1060 /* GU,CG,G,C,A */ - -840 -1070 180 -1070 /* GU,CG,G,C,C */ - -1080 -1060 190 -1060 /* GU,CG,G,C,G */ - -890 -1120 130 -1120 /* GU,CG,G,C,U */ - -1720 -1710 -1710 -1710 /* GU,CG,G,G,A */ - -1530 -1520 -270 -1520 /* GU,CG,G,G,C */ - -2130 -870 -2120 -870 /* GU,CG,G,G,G */ - -1530 -1520 -270 -1520 /* GU,CG,G,G,U */ - -1080 -1060 190 -1060 /* GU,CG,G,U,A */ - -780 -1010 240 -1010 /* GU,CG,G,U,C */ - -1080 -1060 190 -1060 /* GU,CG,G,U,G */ - -1870 -1850 -1850 -1850 /* GU,CG,G,U,U */ - -1210 -1210 -1210 -970 /* GU,CG,U,A,A */ - -1520 -1520 -1520 -1520 /* GU,CG,U,A,C */ - 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400 400 400 -850 /* UG,UG,U,G,G */ - -850 -850 -850 -850 /* UG,UG,U,G,U */ - -850 -850 -850 -850 /* UG,UG,U,U,A */ - -850 -850 -850 -850 /* UG,UG,U,U,C */ - -850 -850 -850 -850 /* UG,UG,U,U,G */ - -850 -850 -850 -850 /* UG,UG,U,U,U */ - 750 240 -260 240 /* UG,AU,A,A,A */ - 440 -60 -570 -60 /* UG,AU,A,A,C */ - -630 -1140 -1650 -1140 /* UG,AU,A,A,G */ - 440 -60 -570 -60 /* UG,AU,A,A,U */ - 460 -50 -560 -50 /* UG,AU,A,C,A */ - 450 -50 -320 -50 /* UG,AU,A,C,C */ - 460 -50 -560 -50 /* UG,AU,A,C,G */ - 450 -50 -320 -50 /* UG,AU,A,C,U */ - -450 -960 -1470 -960 /* UG,AU,A,G,A */ - 440 -60 -570 -60 /* UG,AU,A,G,C */ - 1280 780 -980 780 /* UG,AU,A,G,G */ - 440 -60 -570 -60 /* UG,AU,A,G,U */ - 460 -50 -560 -50 /* UG,AU,A,U,A */ - 450 -50 -320 -50 /* UG,AU,A,U,C */ - 460 -50 -560 -50 /* UG,AU,A,U,G */ - -280 -1030 -1540 -1030 /* UG,AU,A,U,U */ - 240 240 240 240 /* UG,AU,C,A,A */ - -60 -60 -60 -60 /* UG,AU,C,A,C */ - -1140 -900 -1140 -900 /* UG,AU,C,A,G */ - -60 -60 -60 -60 /* UG,AU,C,A,U */ - -50 -50 -50 -50 /* UG,AU,C,C,A */ - 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1090 960 -610 960 /* UA,AU,A,A,C */ - 10 -110 -1690 -110 /* UA,AU,A,A,G */ - 1090 960 -610 960 /* UA,AU,A,A,U */ - 1110 980 -590 980 /* UA,AU,A,C,A */ - 1100 970 -360 970 /* UA,AU,A,C,C */ - 1110 980 -590 980 /* UA,AU,A,C,G */ - 1100 970 -360 970 /* UA,AU,A,C,U */ - 190 60 -1510 60 /* UA,AU,A,G,A */ - 1090 960 -610 960 /* UA,AU,A,G,C */ - 1930 1800 -1020 1800 /* UA,AU,A,G,G */ - 1090 960 -610 960 /* UA,AU,A,G,U */ - 1110 980 -590 980 /* UA,AU,A,U,A */ - 1100 970 -360 970 /* UA,AU,A,U,C */ - 1110 980 -590 980 /* UA,AU,A,U,G */ - 360 0 -1580 0 /* UA,AU,A,U,U */ - 1120 1270 1120 830 /* UA,AU,C,A,A */ - 810 960 810 520 /* UA,AU,C,A,C */ - -260 130 -260 -310 /* UA,AU,C,A,G */ - 810 960 810 520 /* UA,AU,C,A,U */ - 830 980 830 540 /* UA,AU,C,C,A */ - 820 970 820 530 /* UA,AU,C,C,C */ - 830 980 830 540 /* UA,AU,C,C,G */ - 820 970 820 530 /* UA,AU,C,C,U */ - -80 300 -80 -130 /* UA,AU,C,G,A */ - 810 960 810 520 /* UA,AU,C,G,C */ - 1650 1800 1650 1360 /* UA,AU,C,G,G */ - 810 960 810 520 /* UA,AU,C,G,U */ - 830 980 830 540 /* UA,AU,C,U,A */ - 820 970 820 530 /* UA,AU,C,U,C */ - 830 980 830 540 /* UA,AU,C,U,G */ - -150 0 -150 -440 /* UA,AU,C,U,U */ - 0 1270 2050 1270 /* UA,AU,G,A,A */ - -310 960 1740 960 /* UA,AU,G,A,C */ - -1390 -110 -580 -110 /* UA,AU,G,A,G */ - -310 960 1740 960 /* UA,AU,G,A,U */ - -290 980 1760 980 /* UA,AU,G,C,A */ - -60 970 1750 970 /* UA,AU,G,C,C */ - -290 980 1760 980 /* UA,AU,G,C,G */ - -60 970 1750 970 /* UA,AU,G,C,U */ - -1210 60 -400 60 /* UA,AU,G,G,A */ - -310 960 1740 960 /* UA,AU,G,G,C */ - -720 1800 80 1800 /* UA,AU,G,G,G */ - -310 960 1740 960 /* UA,AU,G,G,U */ - -290 980 1760 980 /* UA,AU,G,U,A */ - -60 970 1750 970 /* UA,AU,G,U,C */ - -290 980 1760 980 /* UA,AU,G,U,G */ - -1280 0 -470 0 /* UA,AU,G,U,U */ - 1120 1140 1120 570 /* UA,AU,U,A,A */ - 810 830 810 20 /* UA,AU,U,A,C */ - -260 0 -260 -1050 /* UA,AU,U,A,G */ - 810 830 810 20 /* UA,AU,U,A,U */ - 830 850 830 40 /* UA,AU,U,C,A */ - 820 840 820 30 /* UA,AU,U,C,C */ - 830 850 830 40 /* UA,AU,U,C,G */ - 820 840 820 30 /* UA,AU,U,C,U */ - -80 180 -80 -870 /* UA,AU,U,G,A */ - 810 830 810 20 /* UA,AU,U,G,C */ - 1650 1670 1650 -380 /* UA,AU,U,G,G */ - 810 830 810 20 /* UA,AU,U,G,U */ - 830 850 830 40 /* UA,AU,U,U,A */ - 820 840 820 30 /* UA,AU,U,U,C */ - 830 850 830 40 /* UA,AU,U,U,G */ - -150 -130 -150 -940 /* UA,AU,U,U,U */ - 1470 1340 -230 1340 /* UA,UA,A,A,A */ - 1190 1060 -510 1060 /* UA,UA,A,A,C */ - 60 -60 -1640 -60 /* UA,UA,A,A,G */ - 1190 1060 -510 1060 /* UA,UA,A,A,U */ - 1340 1210 -360 1210 /* UA,UA,A,C,A */ - 1340 1210 -120 1210 /* UA,UA,A,C,C */ - 1340 1210 -360 1210 /* UA,UA,A,C,G */ - 1210 1080 -250 1080 /* UA,UA,A,C,U */ - -230 -360 -1940 -360 /* UA,UA,A,G,A */ - 1190 1060 -510 1060 /* UA,UA,A,G,C */ - 2120 1990 -830 1990 /* UA,UA,A,G,G */ - 1190 1060 -510 1060 /* UA,UA,A,G,U */ - 1340 1210 -360 1210 /* UA,UA,A,U,A */ - 900 770 -560 770 /* UA,UA,A,U,C */ - 1340 1210 -360 1210 /* UA,UA,A,U,G */ - 640 270 -1300 270 /* UA,UA,A,U,U */ - 1190 1340 1190 900 /* UA,UA,C,A,A */ - 910 1060 910 620 /* UA,UA,C,A,C */ - -210 180 -210 -260 /* UA,UA,C,A,G */ - 910 1060 910 620 /* UA,UA,C,A,U */ - 1060 1210 1060 770 /* UA,UA,C,C,A */ - 1060 1210 1060 770 /* UA,UA,C,C,C */ - 1060 1210 1060 770 /* UA,UA,C,C,G */ - 930 1080 930 640 /* UA,UA,C,C,U */ - -510 -120 -510 -560 /* UA,UA,C,G,A */ - 910 1060 910 620 /* UA,UA,C,G,C */ - 1840 1990 1840 1550 /* UA,UA,C,G,G */ - 910 1060 910 620 /* UA,UA,C,G,U */ - 1060 1210 1060 770 /* UA,UA,C,U,A */ - 620 770 620 330 /* UA,UA,C,U,C */ - 1060 1210 1060 770 /* UA,UA,C,U,G */ - 120 270 120 -170 /* UA,UA,C,U,U */ - 60 1340 2120 1340 /* UA,UA,G,A,A */ - -210 1060 1840 1060 /* UA,UA,G,A,C */ - -1340 -60 -530 -60 /* UA,UA,G,A,G */ - -210 1060 1840 1060 /* UA,UA,G,A,U */ - -60 1210 1990 1210 /* UA,UA,G,C,A */ - 180 1210 1990 1210 /* UA,UA,G,C,C */ - -60 1210 1990 1210 /* UA,UA,G,C,G */ - 50 1080 1860 1080 /* UA,UA,G,C,U */ - -1640 -360 -830 -360 /* UA,UA,G,G,A */ - -210 1060 1840 1060 /* UA,UA,G,G,C */ - -530 1990 270 1990 /* UA,UA,G,G,G */ - -210 1060 1840 1060 /* UA,UA,G,G,U */ - -60 1210 1990 1210 /* UA,UA,G,U,A */ - -260 770 1550 770 /* UA,UA,G,U,C */ - -60 1210 1990 1210 /* UA,UA,G,U,G */ - -1000 270 -200 270 /* UA,UA,G,U,U */ - 1190 1210 1190 640 /* UA,UA,U,A,A */ - 910 930 910 120 /* UA,UA,U,A,C */ - -210 50 -210 -1000 /* UA,UA,U,A,G */ - 910 930 910 120 /* UA,UA,U,A,U */ - 1060 1080 1060 270 /* UA,UA,U,C,A */ - 1060 1080 1060 270 /* UA,UA,U,C,C */ - 1060 1080 1060 270 /* UA,UA,U,C,G */ - 930 950 930 140 /* UA,UA,U,C,U */ - -510 -250 -510 -1300 /* UA,UA,U,G,A */ - 910 930 910 120 /* UA,UA,U,G,C */ - 1840 1860 1840 -200 /* UA,UA,U,G,G */ - 910 930 910 120 /* UA,UA,U,G,U */ - 1060 1080 1060 270 /* UA,UA,U,U,A */ - 620 640 620 -170 /* UA,UA,U,U,C */ - 1060 1080 1060 270 /* UA,UA,U,U,G */ - 120 140 120 -670 /* UA,UA,U,U,U */ - -# hairpin - INF INF INF 540 560 570 540 600 550 640 - 650 660 670 680 690 690 700 710 710 720 - 720 730 730 740 740 750 750 750 760 760 - 770 - -# hairpin_enthalpies - INF INF INF 130 480 360 -290 130 -290 500 - 500 500 500 500 500 500 500 500 500 500 - 500 500 500 500 500 500 500 500 500 500 - 500 - -# bulge - INF 380 280 320 360 400 440 460 470 480 - 490 500 510 520 530 540 540 550 550 560 - 570 570 580 580 580 590 590 600 600 600 - 610 - -# bulge_enthalpies - INF 1060 710 710 710 710 710 710 710 710 - 710 710 710 710 710 710 710 710 710 710 - 710 710 710 710 710 710 710 710 710 710 - 710 - -# interior - INF INF INF INF 110 200 200 210 230 240 - 250 260 270 280 290 290 300 310 310 320 - 330 330 340 340 350 350 350 360 360 370 - 370 - -# interior_enthalpies - INF INF INF INF -720 -680 -130 -130 -130 -130 - -130 -130 -130 -130 -130 -130 -130 -130 -130 -130 - -130 -130 -130 -130 -130 -130 -130 -130 -130 -130 - -130 - -# ML_params - 0 0 930 3000 -90 -220 - -# NINIO - 60 320 300 - -# Misc - 410 360 50 370 - -# Triloops -CAACG 680 2370 -GUUAC 690 1080 - -# Tetraloops -CAACGG 550 690 -CCAAGG 330 -1030 -CCACGG 370 -330 -CCCAGG 340 -890 -CCGAGG 350 -660 -CCGCGG 360 -750 -CCUAGG 370 -350 -CCUCGG 250 -1390 -CUAAGG 360 -760 -CUACGG 280 -1070 -CUCAGG 370 -660 -CUCCGG 270 -1290 -CUGCGG 280 -1070 -CUUAGG 350 -620 -CUUCGG 370 -1530 -CUUUGG 370 -680 - -# Hexaloops -ACAGUACU 280 -1680 -ACAGUGAU 360 -1140 -ACAGUGCU 290 -1280 -ACAGUGUU 180 -1540 - - -#END diff --git a/templates/cheader b/templates/cheader deleted file mode 100644 --- a/templates/cheader +++ /dev/null @@ -1,61 +0,0 @@ - - -/* - Automatically generated using the TurnerParser - TurnerParser (c) 2008,2009,2010 - Christian Hoener zu Siederdissen, TBI Vienna - choener (at) tbi.univie.ac.at - - The library enabling this can be found at: - http://hackage.haskell.org/package/BiobaseVienna - the program can be found at: - (sorry, not yet) - install using cabal: cabal install (sorry, not yet) -*/ - -/* - Current free energy parameters are summarized in: - - D.H.Mathews, J. Sabina, M. ZUker, D.H. Turner - "Expanded sequence dependence of thermodynamic parameters improves - prediction of RNA secondary structure" - JMB, 288, pp 911-940, 1999 - - Enthalpies taken from: - - A. Walter, D Turner, J Kim, M Lyttle, P M"uller, D Mathews, M Zuker - "Coaxial stacking of helices enhances binding of oligoribonucleotides.." - PNAS, 91, pp 9218-9222, 1994 - - D.H. Turner, N. Sugimoto, and S.M. Freier. - "RNA Structure Prediction", - Ann. Rev. Biophys. Biophys. Chem. 17, 167-192, 1988. - - John A.Jaeger, Douglas H.Turner, and Michael Zuker. - "Improved predictions of secondary structures for RNA", - PNAS, 86, 7706-7710, October 1989. - - L. He, R. Kierzek, J. SantaLucia, A.E. Walter, D.H. Turner - "Nearest-Neighbor Parameters for GU Mismatches...." - Biochemistry 1991, 30 11124-11132 - - A.E. Peritz, R. Kierzek, N, Sugimoto, D.H. Turner - "Thermodynamic Study of Internal Loops in Oligoribonucleotides..." - Biochemistry 1991, 30, 6428--6435 -*/ - - - -#include "energy_const.h" -/*@unused@*/ -static char rcsid[] = "$Id: energy_par.c,v 1.6 2004/08/12 12:11:57 ivo Exp $"; - -#define NST 0 /* Energy for nonstandard stacked pairs */ -#define DEF -50 /* Default terminal mismatch, used for I */ - /* and any non_pairing bases */ -#define NSM 0 /* terminal mismatch for non standard pairs */ - -#define PUBLIC - -PUBLIC double Tmeasure = 37+K0; /* temperature of param measurements */ -