Biobase 0.0.2.1 → 0.1.0.0

raw patch · 26 files changed

+10426/−7 lines, 26 filesdep +HsToolsdep +ParsecToolsdep +bytestringdep ~vectorPVP ok

version bump matches the API change (PVP)

Dependencies added: HsTools, ParsecTools, bytestring, containers, directory, file-embed, filemanip, parsec, split, tuple

Dependency ranges changed: vector

API changes (from Hackage documentation)

Files

• Biobase.cabal +60/−7
• Biobase/Constants.hs +13/−0
• Biobase/Infernal/CM.hs +326/−0
• Biobase/Infernal/CM/Export.hs +76/−0
• Biobase/Infernal/CM/Import.hs +194/−0
• Biobase/Infernal/Stockholm.hs +16/−0
• Biobase/Infernal/Stockholm/Import.hs +35/−0
• Biobase/Turner.hs +41/−0
• Biobase/Turner/Import.hs +176/−0
• Biobase/Turner/Tables.hs +133/−0
• Biobase/Types/Convert.hs +36/−0
• Biobase/Types/Energy.hs +51/−0
• Biobase/Types/Partition.hs +84/−0
• Biobase/Types/Ring.hs +22/−0
• Biobase/Types/Score.hs +48/−0
• Biobase/Vienna.hs +89/−0
• Biobase/Vienna/Default.hs +27/−0
• Biobase/Vienna/Export/ViennaC.hs +264/−0
• Biobase/Vienna/Export/ViennaPar.hs +139/−0
• Biobase/Vienna/Import/Turner.hs +71/−0
• Biobase/Vienna/Import/ViennaPar.hs +123/−0
• Biobase/Vienna/Modification/NonStandard.hs +121/−0
• Biobase/Vienna/Modification/Partition.hs +51/−0
• Biobase/Vienna/Modification/Temperature.hs +34/−0
• parfiles/Turner2004GH.par +8135/−0
• templates/cheader +61/−0

@@ -1,5 +1,5 @@ name:           Biobase-version:        0.0.2.1+version:        0.1.0.0 author:         Christian Hoener zu Siederdissen maintainer:     choener@tbi.univie.ac.at homepage:       http://www.tbi.univie.ac.at/~choener/Haskell/@@ -12,28 +12,81 @@ stability:      experimental cabal-version:  >= 1.4.0 description:-                Base library for bioinformatics providing a number of im- and-                export functions for commonly used filetypes. Provided are-                functions and Haskell data types for RNA primary and secondary-                structure. Otherwise, this library provides the basis for other-                libraries to build on.+                Base library for bioinformatics providing the following features:+                .+                - RNA primary and secondary structure+                - Infernal covariance models+                - Turner and Vienna energy files+                .+                - efficient format for RNA sequences, based on the vector package+                - import from strings, bytestrings, fasta files (using the bio library)+                - secondary structure manipulation functions, im- and export of Vienna-dotbracket notation+                - import Turner energy files+                - cf. http://rna.urmc.rochester.edu/NNDB/index.html+                - im- and export of Vienna 2.0 energy files+                .+                - import covariance models+                - basic manipulation of covariance models+                - Stockholm file format manipulation+                .+                - algebraic ring class+                - instances for Gibbs free energy, partition function probabilities, and scores+                - conversion between different entities+                - ready for the vector library   +extra-source-files:+  parfiles/Turner2004GH.par,+  templates/cheader+ library   build-depends:     array,     base >=4 && <5,-    vector >=0.7 && <8,+    bytestring,+    containers,+    directory >=1,+    file-embed >=0.0.3,+    filemanip >=0.3.3 && <0.4,+    parsec >=3 && <4,     primitive >=0.3 && <0.4,+    tuple >=0.2.0.1,+    vector >=0.7 && <0.8,+    split >=0.1.2.3,++    HsTools >=0.0.1.1 && <0.0.2,+    ParsecTools >=0.0.2 && <0.0.3,     PrimitiveArray >=0.0.2.1 && <0.0.3    exposed-modules:     Biobase.Constants+    Biobase.Infernal.CM+    Biobase.Infernal.CM.Export+    Biobase.Infernal.CM.Import+    Biobase.Infernal.Stockholm+    Biobase.Infernal.Stockholm.Import     Biobase.RNA     Biobase.Structure     Biobase.Structure.DotBracket     Biobase.Structure.Shapes+    Biobase.Turner+    Biobase.Turner.Import+    Biobase.Turner.Tables+    Biobase.Types.Convert+    Biobase.Types.Energy+    Biobase.Types.Partition+    Biobase.Types.Ring+    Biobase.Types.Score+    Biobase.Vienna+    Biobase.Vienna.Default+    Biobase.Vienna.Export.ViennaC+    Biobase.Vienna.Export.ViennaPar+    Biobase.Vienna.Import.Turner+    Biobase.Vienna.Import.ViennaPar+    Biobase.Vienna.Modification.NonStandard+    Biobase.Vienna.Modification.Partition+    Biobase.Vienna.Modification.Temperature    ghc-options:     -O2

@@ -27,3 +27,16 @@  fInf :: Double fInf = 1/0+++-- * some constants, required for scaling and Boltzmann++++-- Kelvin / Celsius conversion constant++kelvinC0 = 273.15++-- universal gas constant++gasconst = 1.98717 -- cal/K

@@ -0,0 +1,326 @@++--+-- Stores Infernal Covariance Model data. Built for ease of use, not speed but+-- should work reasonably well.+--++-- TODO Data.Vector?+--+-- TODO use generics?+--+-- TODO functions to change to probabilities!+--+-- TODO cmCanonize function!+--+-- TODO put functions into their own modules, a bit of cleanup+--+-- TODO add functions to insert a new node between two already existing nodes; think about how to handle BIF+--+-- TODO add ability to remove node; think about how to handle BIF+--+-- NOTE maybe BIF should not be insertable/removable right now?++module Biobase.Infernal.CM where+++import Data.Array.IArray+import Data.List (genericLength)++import Biobase.RNA hiding (nucE) -- "E type" nucleotides do not happen in CMs!++++-- * Data types for Covariance Models++-- {{{ Data types++-- | A complete covariance model. Each node and each state can be tagged with+-- additional data. Typically, say after parsing, the tag will be ().++data CM n s = CM+  { nodes      :: Array Int (Node n)+  , states     :: Array Int (State s)+  , header     :: [(String,String)] -- keeps the list of header entries sorted!+  , localBegin :: Array Int Double+  , localEnd   :: Array Int Double+  , cmType     :: CMType+  , nullModel  :: Array Nucleotide Double+  } deriving (Show)++-- | Describes one node++data Node n = Node+  { nid :: Int+  , ntype :: NodeType+  , nparents :: [Int] -- TODO can there be more than one?+  , nchildren :: [Int]+  , nstates :: [Int]+  , ntag :: n+  } deriving (Show)++-- | One state++data State s = State+  { sid :: Int+  , stype :: StateType+  , snode :: Int+  , sparents :: [Int]+  , schildren :: [Transition]+  , semission :: [Emission]+  , stag :: s+  } deriving (Show)++-- | CMType is important if we want to set localBegin / localEnd!++data CMType = CMProb | CMScore+  deriving (Show,Eq)++-- | can emit either one nucleotide or a pair++data Emission+  = EmitS {eNuc :: Nucleotide, escore :: Double}+  | EmitP { eNucL :: Nucleotide, eNucR :: Nucleotide, escore :: Double}+  deriving (Show)++-- | branches are transition without attached probability becaue both branches are always taken++data Transition+  = Branch {tchild :: Int}+  | Transition {tchild :: Int, tscore :: Double}+  deriving (Show)++-- | the different node types++data NodeType = MATP | MATL | MATR | BIF | ROOT | BEGL | BEGR | END+  deriving (Read,Show,Eq,Ord,Enum,Bounded)++-- | the different state types++data StateType = MP | IL | IR | D | ML | MR | B | S | E+  deriving (Read,Show,Eq,Ord,Enum,Bounded)++-- }}}+++-- * make a local model out of a global one++-- | generate a local model with local begin prob and local end prob++cmMakeLocal :: Double -> Double -> CM n s -> CM n s+cmMakeLocal pbegin pend cm = cmMakeLocalBegin pbegin $ cmMakeLocalEnd pend cm++++cmMakeLocalBegin :: Double -> CM n s -> CM n s+cmMakeLocalBegin pbegin cm = cm{localBegin = localBegin cm // changes} where+  changes = rootS : (start : intern)+  rootS = (0, prob2Score 0 1.0) -- root disabled!+  start = (head . nstates $ nodes cm ! 1, prob2Score (1-pbegin) 1.0) -- the first state after "root 0"+  intern = map (\k -> (sid $ nodeMainState cm k,prob2Score (pbegin / l) 1.0)) nds+  nds = filter (localBeginPossible cm) . elems $ nodes cm+  l = genericLength nds++++-- TODO have to change the transition score, too!++cmMakeLocalEnd :: Double -> CM n s -> CM n s+cmMakeLocalEnd pend cm = cm{localEnd = localEnd cm // changes} where+  changes = map (\k -> (sid $ nodeMainState cm k,prob2Score (pend / l) 1.0)) nds+  nds = filter (localBeginPossible cm) . elems $ nodes cm+  l = genericLength nds++++-- * Transform between score and probability mode++-- | given a CM in score mode, change it to probability mode++cmScore2Prob :: CM n s -> CM n s+cmScore2Prob cm' = if cmType cm' == CMProb then cm' else CM+  (nodes  cm)+  (statesScore2Prob cm $ states cm)+  (header cm)+  (localBeginScore2Prob $ localBegin cm)+  (localEndScore2Prob   $ localEnd   cm)+  CMProb+  nm+  where+    nm = amap (flip score2Prob 0.25) $ nullModel cm'+    cm = cm' {nullModel = nm}+++-- | Given a CM in prob mode, change to score mode++cmProb2Score :: CM n s -> CM n s+cmProb2Score cm' = if cmType cm' == CMScore then cm' else CM+  (nodes  cm)+  (statesProb2Score cm $ states cm)+  (header cm)+  (localBeginProb2Score $ localBegin cm)+  (localEndProb2Score   $ localEnd   cm)+  CMScore+  nm+  where+    nm = amap (flip prob2Score 0.25) $ nullModel cm'+    cm = cm' {nullModel = nm}++++-- | normalize all PROBabilities in a CM++cmNormalizeProbabilities :: CM n s -> CM n s+cmNormalizeProbabilities cm+  | cmType cm == CMScore = error "cannot normalize score-type CM"+  | otherwise            = cm -- TODO have to map normalization over all scores!++++-- {{{ CM score/prob conversion helpers++statesScore2Prob :: CM n s -> Array Int (State s) -> Array Int (State s)+statesScore2Prob cm sA = amap f sA where+  f s = s {schildren = map fT $ schildren s, semission = map fE $ semission s}+  fT b@(Branch _) = b+  fT (Transition k v) = Transition k (score2Prob v 1.0)+  fE (EmitS k v) = EmitS k (score2Prob v $ nullModel cm ! k)+  fE (EmitP k1 k2 v) = EmitP k1 k2 (score2Prob v $ (nullModel cm ! k1) * (nullModel cm ! k2))++++localBeginScore2Prob :: Array Int Double -> Array Int Double+localBeginScore2Prob sA = amap f sA where+  f s = score2Prob s 1.0++++localEndScore2Prob :: Array Int Double -> Array Int Double+localEndScore2Prob sA = amap f sA where+  f s = score2Prob s 1.0++++statesProb2Score :: CM n s -> Array Int (State s) -> Array Int (State s)+statesProb2Score cm sA = amap f sA where+  f s = s {schildren = map fT $ schildren s, semission = map fE $ semission s}+  fT b@(Branch _) = b+  fT (Transition k v) = Transition k (prob2Score v 1.0)+  fE (EmitS k v) = EmitS k (prob2Score v $ nullModel cm ! k)+  fE (EmitP k1 k2 v) = EmitP k1 k2 (prob2Score v $ (nullModel cm ! k1) * (nullModel cm ! k2))++++localBeginProb2Score :: Array Int Double -> Array Int Double+localBeginProb2Score sA = amap f sA where+  f s = prob2Score s 1.0++++localEndProb2Score :: Array Int Double -> Array Int Double+localEndProb2Score sA = amap f sA where+  f s = score2Prob s 1.0++-- }}}+++++-- * Helper Functions++-- {{{ helper functions++-- | extract the main state for each node (eg MP state for MATP node)++-- TODO shouldn't this just be "head $ nstates n"?++nodeMainState :: CM n s -> Node n -> State s+nodeMainState cm n = head $ filter ((==st) . stype) ss where+  (Just st) = (ntype n) `lookup` nodeMainStateAssocs+  ss = map (states cm !) $ nstates n+++-- | Checks for each node, if it can be target of a local begin.++localBeginPossible :: CM n s -> Node n -> Bool+localBeginPossible cm n =+  if ntype n `elem` okNodes+  && (not . any (==0) $ nparents n) -- nodes reachable from "root" (that is: node 1) have handled specially+    then True+    else False+  where+    okNodes = [MATP,MATL,MATR,BIF]++++-- | Checks for each node if it can lead to a local end.++localEndPossible :: CM n s -> Node n -> Bool+localEndPossible cm n =+  if ntype n `elem` okNodes+  && (END /= (ntype $ nodes cm ! (nid n +1)))+    then True+    else False+  where+    okNodes = [MATP,MATL,MATR,BEGL,BEGR]++++-- | transform scores into probabilities, given a nullmodel for x++-- TODO quickcheck!++score2Prob x null+  | x == (-1/0) = 0+  | otherwise   = exp (x * log 2) * null++++-- | back into scores++prob2Score x null+  | x == 0    = (-1/0)+  | otherwise = log (x / null) / log 2++++-- | Transform a state, setting probabilities instead of scores. Requires CM+-- knowledge for background model.++-- TODO actually use the background model++stateScore2Prob :: CM n s -> State s -> State s+stateScore2Prob cm s = error "implement me"++++-- | Transform a state, setting scores instead of probabilities.++stateProb2Score :: CM n s -> State s -> State s+stateProb2Score cm s = error "implement me"+transitionTargets :: [Transition] -> [Int]+transitionTargets xs = map f xs where+  f (Branch x)       = x+  f (Transition x _) = x+++nodeMainStateAssocs :: [(NodeType,StateType)]+nodeMainStateAssocs =+  [ (MATP, MP)+  , (MATL, ML)+  , (MATR, MR)+  , (BIF,  B)+  , (ROOT, S)+  , (BEGL, S)+  , (BEGR, S)+  , (END,  E)+  ]++-- }}}++++-- TODO score -> prob : exp (x / log 2) -- CHECK THIS!!!+-- score -> prob : exp (x * log 2)+-- prob -> score : (log x) / log 2+-- TODO mkGlobal (needed?)+-- TODO use logsum : log (exp x + exp y) = x + log (1 + exp (y-x)), where x>y

@@ -0,0 +1,76 @@+{-# LANGUAGE RecordWildCards #-}++-- | write an Infernal model. We aim for version 1.0.2 of Infernal but right+-- now, there is no explicit version management! We just return header+-- information as we read it. So we are compatible to all versions that can be+-- parsed but have no safeguards in place.+--+-- NOTE: exported model can apparently be calibrated.+--+-- TODO make sure that (Export.toString . Import.fromString == id); the other+-- way around is not absolutely necessary (except if the Infernal parser should+-- require this at some point)+--+-- TODO put functions like stringS into another module?++module Biobase.Infernal.CM.Export where++import qualified Data.Array.IArray as A+import Text.Printf++import Biobase.Infernal.CM++import Biobase.Infernal.CM.Import -- TODO for testing only!++++-- | Main export function for CMs. Creates a string that is accepted by+-- Infernal++toString :: CM n s -> String+toString cm@CM{..} = unlines $ hdr ++ ["MODEL:"] ++ nds ++ ["//"]+  where+    hdr = map (\(k,v) -> k ++ " " ++ v) header+    nds = concatMap (nodeToString cm) $ A.elems nodes++++-- | export a specific node, used by 'toString'++nodeToString :: CM n s -> Node n -> [String]+nodeToString cm Node{..} = printf "\t\t\t\t[ %s %d ]" (show ntype) nid : map (stateToString cm . (states cm A.!)) nstates++++-- | export a specific states, used by 'nodeToString'++stateToString :: CM n s -> State s -> String+stateToString cm State{..} = printf "    %2s %6d %6d %2d %6d %6d %-55s %s" (show stype) sid maxP numP minC numC tscores escores+  where+    maxP+      | null sparents = -1+      | otherwise     = maximum sparents+    numP = length sparents+    minC+      | null schildren = -1+      | otherwise      = minimum $ map tchild schildren+    numC+      | stype == B = maximum $ map tchild schildren+      | otherwise  = length schildren+    tscores :: String+    tscores+      | stype == B = ""+      | otherwise  = concatMap (printf "%s   " . stringS . tscore) schildren+    escores :: String+    escores+      | null semission = ""+      | otherwise      = concatMap (printf "%.3f " . escore) semission++++-- | export scores for transitions with the Infernal-specific "-infinity" value+-- of "*"++stringS x+  | x == (-1/0) = "      *"+  | otherwise   = printf "%.3f" x

@@ -0,0 +1,194 @@++--+-- A parser for Infernal's Covariance Models (CM). Should work with version 1.0+-- of Infernal.+--++-- TODO use generics?+--+-- TODO importing the cmcalibrate calibration data is currently broken! (data is parsed as separate lines)++module Biobase.Infernal.CM.Import (fromFile,fromString) where++import Data.Maybe (fromJust)+import qualified Data.Array.IArray as A+import qualified Data.List as L+import Text.ParserCombinators.Parsec hiding (State)++import Biobase.Infernal.CM+import Biobase.RNA hiding (nucE)++++-- {{{ Parsec++myChar = alphaNum <|> char '-' <|> char '_' <|> char '.'+headerChar = myChar <|> char '[' <|> char ']'+floating = many1 $ digit <|> char '.' <|> char 'e' <|> char '-'++headerLine = do+  key <- many1 headerChar+  --spaces+  many1 $ char ' '+  val <- many1 (headerChar <|> char ' ' <|> char '/' <|> char ':')+  newline+  return (key,val)++unknownNumbers = do+  many1 $ char ' '+  ns <- floating `sepEndBy` (many1 $ char ' ')+  newline+  return ("",concat ns)++theHeader = do+  hs <- many $ (try headerLine <|> try unknownNumbers)+  string "MODEL:"+  newline+  return hs++-- }}}++-- {{{ Node++node = do+  spaces+  string "[ "+  name <- many letter+  spaces+  num <- many digit >>= (return . read)+  spaces+  string "]"+  newline+  states <- many $ try (state num)+  return $ (Node+             { ntype = read name+             , nid = num+             , nstates = map sid states+             , nparents = []+             , nchildren = []+             , ntag = ()+             }+            , states)++-- }}}++-- {{{ stuff++-- TODO put some of this into HsTools/Parsec stuff++aNum = many1 $ char '-' <|> digit+addneginf :: String -> Double+addneginf "*" = (-1)/0 --"-1000000000.0"+addneginf x = read x++-- }}}++-- {{{ State++state nodeID = do+  spaces+  name <- many1 myChar+  spaces+  sid <- aNum >>= (return . read)+  spaces+  plast <- aNum >>= (return . read)+  spaces+  pnum <- aNum >>= (return . read)+  spaces+  cfirst <- aNum >>= (return . read)+  spaces+  cnum <- aNum >>= (return . read)+  probs <- ( (many $ myChar <|> char '*') `sepBy` (many1 $ char ' ') >>=+             return . map addneginf . filter ((/=) "") )+  newline+  let s = case name of+            "B" -> State+                    { stype = read name+                    , sid = sid+                    , snode = nodeID+                    , sparents = [plast-pnum+1 .. plast]+                    , schildren = [Branch cfirst, Branch cnum]+                    , semission = []+                    , stag = ()+                    }+            _   -> State+                    { stype = read name+                    , sid = sid+                    , snode = nodeID+                    , sparents = [plast-pnum+1 .. plast]+                    , schildren = zipWith Transition [cfirst .. cfirst+cnum-1] probs+                    , semission = let keep = drop cnum probs in+                        case length keep of+                          0  -> []+                          4  -> zipWith EmitS acgu keep+                          16 -> zipWith (\(k1,k2) v -> EmitP k1 k2 v) acguPairs keep+                          _  -> error $ "strange number of probabilities" ++ show (keep)+                    , stag = ()+                    }+  return s++-- }}}++-- {{{ Model++models = do+  ms <- many model+  eof+  return ms++model = do+  h <- theHeader+  ns <- many node+  let states = concatMap snd ns+  let nodes = map (addPCinfo states . fst) ns+  -- just add all the node parent / child info+  string "//"+  newline+  -- eof -- removed, we want to be able to read concatenated models!+  return $ CM+            { nodes      = A.array (0, length nodes -1)  $ zip (map nid nodes)  nodes+            , states     = A.array (0, length states -1) $ zip (map sid states) states+            , header     = h+            , localBegin = A.array (0, length states -1) $ zip [0 .. length states -1] (0.0 : repeat (-1/0))+            , localEnd   = A.array (0, length states -1) $ zip [0 .. length states -1] (repeat (-1/0))+            , cmType     = CMScore+            , nullModel  = A.array (nucA,nucU) $ zip acgu (map read . words . fromJust $ "NULL" `lookup` h) -- TODO circumvents the whole parsing stuff!+            }++-- }}}++-- {{{ Stuff++addPCinfo states n =+  let+    s = nstates n+    sp = L.nub $ L.sort $ concatMap (sparents . (states !!)) s+    sc = L.nub $ L.sort $ concatMap (transitionTargets . schildren . (states !!)) s+    np = (L.nub $ L.sort $ map (snode . (states !!)) sp) L.\\ [nid n]+    nc = (L.nub $ L.sort $ map (snode . (states !!)) sc) L.\\ [nid n]+  in+    n {nparents = np, nchildren = nc}++++-- | Two types of parsing, once using a file and once by parsing a string.++fromFile f = parseFromFile models f+fromString s = parse models "(stdin)" s++-- }}}++-- | Helper function to remove impossible state transitions (those that have+-- -infty score).++-- TODO move to InfernalCM.hs and have it for Prob and Score both++{-+canonize cm = cm {states = A.amap f $ states cm} where+  f s = s {schildren = filter g $ schildren s}+  g (Branch _)    = True+  g (Transition _ v) = +  h (_,s)+    | s == (-1)/0 = False+    | otherwise   = True+-}

@@ -0,0 +1,16 @@++-- | The beginnings of a Stockholm File parser.++module Biobase.Infernal.Stockholm where++-- | Stockholm format data. We have a set of sequences with sequence data, a+-- set of column annotations and unknown data (actually: known, but we do not+-- care).++data Stockholm = Stockholm+  { sequences :: [(String,String)]+  , colAnnotations :: [(String,String)]   -- #=GC tag+  , exAnnotations :: [(String,String)]    -- NOTE this is not in the Stockholm format!+  , unknown :: [String]+  }+  deriving (Show)

@@ -0,0 +1,35 @@++-- | A simple parser for Stockholm data. As we do not interpret most stuff+-- right now, Parsec is not required.++module Biobase.Infernal.Stockholm.Import where++import Biobase.Infernal.Stockholm+import Data.List++fromFile :: String -> IO Stockholm+fromFile fname = do+  ls <- readFile fname >>= return . filter (not . null) . lines+  let (colanno, rest1) = partition (\x -> length x >= 4 && (and $ zipWith (==) "#=GC" x)) ls+  let (seqdata, rest2) = partition (\(x:_) -> x/='#' && x/='/') rest1+  let (exdata , unk)   = partition (\x -> length x >= 4 && (and $ zipWith (==) "#=EX" x)) rest2+  {-+  print colanno+  print rest1+  print seqdata+  print rest2+  print exdata+  print unk+  -}+  return Stockholm+    { sequences      = map (mkPair . words) seqdata+    , colAnnotations = map (mkPair . drop 1 . words) colanno+    , exAnnotations  = map (mkPair . drop 1 . words) exdata+    , unknown        = unk+    }++++mkPair []     = error "empty list"+mkPair [x]    = error $ "just one element: " ++ show x+mkPair (x:xs) = (x,unwords xs)

@@ -0,0 +1,41 @@+{-# LANGUAGE TypeSynonymInstances #-}++-- | Mathews / Turner nearest neighbor energy tables for interactions between+-- RNA-RNA and DNA-DNA. Using lazy tables for easy filling of missing data.+-- Transform tables into uvectors for efficient access.++module Biobase.Turner where++import Biobase.RNA (Nucleotide)+import qualified Biobase.Turner.Tables as T++++-- | Data structure containing all necessary tables for the Turner 2004 model.+-- Note the temperature, using an additional function, rescaling becomes+-- possible. A Show and a Read instance are automatically derived but one+-- should use the Turner and/or Vienna import/export facilities. All data uses+-- complete tables, where any base can pair with any other. Missing data ('.'+-- in tables) is given by 'Nothing', otherwise we have 'Just Int'.+-- +-- In general, have a look here:+-- \url{http://rna.urmc.rochester.edu/NNDB/turner04/index.html} where+-- parameters are explained.+-- +-- Conversion from Turner to Vienna is only possible in one direction as a+-- number of parameters are not used in Vienna RNA Folding.++++-- We are missing tables for DNA-RNA data: helixdr.dat, stackdr.dat,+-- stackdr.dh.  Several other files have unknown data, too. These are:+-- dnadynalign*, fam\_hmm\_pars.dat, helix.dat, int22-exp.dh++type TurnerTables = T.Turner2004 Basepair Nucleotide Double++type TurnerEntropy  = TurnerTables+type TurnerEnthalpy = TurnerTables+type Temperature    = Double+type TurnerSet      = (Temperature,TurnerEntropy,TurnerEnthalpy)++type Basepair = (Nucleotide,Nucleotide)

@@ -0,0 +1,176 @@+{-# LANGUAGE NoMonomorphismRestriction #-}++-- | Turner file parser. Returns a Turner2004 data structure. We store data in+-- the same way it is stored in the ViennaRNA package. Pairs are tuples+-- however.+--+-- How is 'stack' data stored:+--+-- AX+-- UY   ->  ((A,U),(Y,X))+--+-- How 'iloop1x1' is stored:+--+--  X+-- A G+-- U C  -> ((A,U),(C,G),X,Y)+--  Y+--+--  Now 'iloop1x2' is stored:+--+--  X+-- A  G+-- U  C  -> ((A,U),(C,G),X,C,Y), single (X) first, then 5' to 3'+--  YC+--+--  'iloop2x2' is stored:+--+--  XY+-- A  G+-- U  C  -> ((A,U),(C,G),X,Y,y,x), X-->Y then x<--y+--  xy+--+--TODO not sure if dangle3/dangle5 are correctly split or if they should switch++module Biobase.Turner.Import+  ( parseTurner+  ) where++import Control.Applicative+import Control.Arrow (first)+import Control.Monad+import Data.Either+import Data.List.Split (splitEvery)+import Data.List (transpose)+import qualified Data.Map as M+import System.FilePath.Find+import Text.Parsec hiding ((<|>), many)+import Text.Parsec.String++import Biobase.RNA+import Data.Ix.Tuple+import Data.PrimitiveArray+import Data.PrimitiveArray.Ix+import Text.Parsec.Numbers++import Biobase.Turner.Tables++++-- * Associate every file with a parse.++minp = (nucA,nucA)+maxp = (nucU,nucU)+minpb = (minp,nucA)+maxpb = (maxp,nucU)+minpp = (minp,minp)+maxpp = (maxp,maxp)+minppbb = (minp,minp,nucA,nucA)+maxppbb = (maxp,maxp,nucU,nucU)+minppbbb = (minp,minp,nucA,nucA,nucA)+maxppbbb = (maxp,maxp,nucU,nucU,nucU)+minppbbbb = (minp,minp,nucA,nucA,nucA,nucA)+maxppbbbb = (maxp,maxp,nucU,nucU,nucU,nucU)+minpbb = (minp,nucA,nucA)+maxpbb = (maxp,nucU,nucU)+-- (4,3) switched for vienna rna compatibility+keyspp = [((k1,k2),(k4,k3)) | k1 <- acgu, k3 <- acgu, k2 <- acgu, k4 <- acgu]+keyspb = [((k1,k2),k3) | k1 <- acgu, k2 <- acgu, k3 <- acgu]+keyspbb = [((k1,k2),k3,k4) | k1 <- acgu, k3 <- acgu, k2 <- acgu, k4 <- acgu]+plist11 = [(nucA,nucU),(nucC,nucG),(nucG,nucC),(nucU,nucA),(nucG,nucU),(nucU,nucG)]+plist22 = [(nucA,nucU),(nucC,nucG),(nucG,nucC),(nucG,nucU),(nucU,nucA),(nucU,nucG)]+-- (4,3) switched for vienna rna compatibility+keysppbb = [((k1,k2),(k4,k3),k5,k6) | (k1,k2) <- plist11, k5 <- acgu, (k3,k4) <- plist11, k6 <- acgu]+-- (4,3) switched for vienna rna compatibility+keysppbbb = [((k1,k2),(k4,k3),k5,k6,k7) | (k1,k2) <- plist11, k6 <- acgu, k5 <- acgu, (k3,k4) <- plist11, k7 <- acgu]+-- (4,3) switched for vienna rna compatibility, 5786 is 5'3' order top, bottom!+keysppbbbb = [((k1,k2),(k4,k3),k5,k6,k7,k8) | (k1,k2) <- plist22, (k3,k4) <- plist22, k5 <- acgu, k8 <- acgu, k6 <- acgu, k7 <- acgu]+z = 999999++++-- | Given the base dir and a suffix (.dat/.dh most likely), parse the relevant+-- files. The prefix can be used for, eg., dna file++parseTurner prefix basedir fsuffix = do+  vstack <- grabB basedir fsuffix $ prefix ++ "stack"+  vdangles <- grabB basedir fsuffix $ prefix ++ "dangle"+  vlengths <- grabB basedir fsuffix $ prefix ++ "loop"+  vhairmm <- grabB basedir fsuffix $ prefix ++ "tstackh"+  viloopmm <- grabB basedir fsuffix $ prefix ++ "tstacki"+  viloop23mm <- grabB basedir fsuffix $ prefix ++ "tstacki23"+  viloop1nmm <- grabB basedir fsuffix $ prefix ++ "tstacki1n"+  vmultimm <- grabB basedir fsuffix $ prefix ++ "tstackm"+  vextmm <- grabB basedir fsuffix $ prefix ++ "tstack"+  viloop11 <- grabB basedir fsuffix $ prefix ++ "int11"+  viloop12 <- grabB basedir fsuffix $ prefix ++ "int21"+  viloop22 <- grabB basedir fsuffix $ prefix ++ "int22"+  vlookups <- fmap (map (first (map charToNucleotide)) . concat) $ mapM (\f -> grabA basedir fsuffix $ prefix ++ f) ["triloop","tloop","hexaloop"]+  vmisc <- grabB basedir fsuffix $ prefix ++ "miscloop"+  let (vdangle3,vdangle5) = splitAt (length vdangles `div` 2) vdangles+  let (_:viloopl:vbulgel:vhairpinl:[]) = transpose $ splitEvery 4 vlengths+  return $ Turner2004+    { stack = fromAssocs minpp maxpp z $ zip keyspp vstack+    , dangle3 = fromAssocs minpb maxpb z $ zip keyspb vdangle3+    , dangle5 = fromAssocs minpb maxpb z $ zip keyspb vdangle5+    , hairpinL = fromAssocs 0 30 z $ zip [1..] vhairpinl+    , bulgeL = fromAssocs 0 30 z $ zip [1..] vbulgel+    , iloopL = fromAssocs 0 30 z $ zip [1..] viloopl+    , hairpinMM = fromAssocs minpbb maxpbb z $ zip keyspbb vhairmm+    , iloopMM = fromAssocs minpbb maxpbb z $ zip keyspbb viloopmm+    , iloop2x3MM = fromAssocs minpbb maxpbb z $ zip keyspbb viloop23mm+    , iloop1xnMM = fromAssocs minpbb maxpbb z $ zip keyspbb viloop1nmm+    , multiMM = fromAssocs minpbb maxpbb z $ zip keyspbb vmultimm+    , extMM = fromAssocs minpbb maxpbb z $ zip keyspbb vextmm+    , hairpinLookup = M.fromList vlookups+    , iloop1x1 = fromAssocs minppbb   maxppbb   z $ zip keysppbb   viloop11+    , iloop1x2 = fromAssocs minppbbb  maxppbbb  z $ zip keysppbbb  viloop12+    , iloop2x2 = fromAssocs minppbbbb maxppbbbb z $ zip keysppbbbb viloop22+    , ninio = vmisc !! 2+    , maxNinio = vmisc !! 1+    , multiOffset = vmisc !! 6+    , multiNuc = vmisc !! 7+    , multiHelix = vmisc !! 8+    , largeLoop = vmisc !! 0+    , termAU = vmisc !! 14+    , intermolecularInit = vmisc !! 19+    }++grabB basedir fsuffix fname = do+  p <- parseFromFile pBlockFile (basedir ++ "/" ++ fname ++ fsuffix)+  case p of+    (Right ans) -> return ans+    (Left err)  -> error $ show err++grabA basedir fsuffix fname = do+  p <- parseFromFile pAssocFile (basedir ++ "/" ++ fname ++ fsuffix)+  case p of+    (Right ans) -> return ans+    (Left err)  -> error $ show err++++-- * File parser: We do not want to understand the format, just extract all+-- data.++-- | Blocks of data.++pBlockFile = concat <$> many (try numberRow <|> infoRow) <* eof where+  -- a line with a least one number+  numberRow = many (char ' ') *> (number <* notFollowedBy (char '\'')) `sepEndBy1` (many $ char ' ') <* newline+  -- a number is a dot or some extended floating point number+  number = (try dotFloat) <|> (999999 <$ char '.') <|> parseExtFloat <?> "floating point number"++-- | A File with associations.++pAssocFile = concat <$> many1 (try assocRow <|> infoRow) where+  -- one assocs of string, value+  assocRow = (\a b -> [(a,b)]) <$ many (char ' ') <*> many1 (oneOf nuc) <* many (char ' ') <*> parseExtFloat <* many (char ' ')++-- a line with crap+infoRow = [] <$ anyChar `manyTill` newline++-- a rather stupid float+dotFloat = (\s a b -> read $ s:'0':a:b) <$> (char '-' <|> pure ' ') <*> char '.' <*> many1 digit++nuc = "ACGUT"

@@ -0,0 +1,133 @@+{-# LANGUAGE TemplateHaskell #-}+{-# LANGUAGE DeriveFunctor #-}+{-# LANGUAGE RecordWildCards #-}+{-# LANGUAGE TypeSynonymInstances #-}++-- | Turner Nearest Neighbor Energy Tables}++-- TODO (Read) instance? (Vector has no Read instance...)++module Biobase.Turner.Tables where++import qualified Data.Map as M++import Data.PrimitiveArray+import Data.PrimitiveArray.Ix++++-- | A data structure describing all fields as used by the Turner 2004+-- parameter set. Some fields are commented out until they are being used.++data Turner2004 a b c = Turner2004+  { stack :: PrimArray (a,a) c+  , dangle3 :: PrimArray (a,b) c+  , dangle5 :: PrimArray (a,b) c+  , hairpinL :: PrimArray Int c+  , hairpinMM :: PrimArray (a,b,b) c+  , hairpinLookup :: M.Map [b] c+--  , hairpinGGG :: c+--  , hairpinCslope :: c+--  , hairpinCintercept :: c+--  , hairpinC3 :: c+  , bulgeL :: PrimArray Int c+--  , bulgeSingleC :: c+  , iloop1x1 :: PrimArray (a,a,b,b) c+  , iloop1x2 :: PrimArray (a,a,b,b,b) c+  , iloop2x2 :: PrimArray (a,a,b,b,b,b) c+  , iloopMM :: PrimArray (a,b,b) c+  , iloop2x3MM :: PrimArray (a,b,b) c+  , iloop1xnMM :: PrimArray (a,b,b) c+  , iloopL :: PrimArray Int c+  , multiMM :: PrimArray (a,b,b) c+  , ninio :: c+  , maxNinio :: c+  , multiOffset :: c+  , multiNuc :: c+  , multiHelix :: c+--  , multiAsym :: c+--  , multiStrain :: c+  , extMM :: PrimArray (a,b,b) c+--  , coaxStack :: PrimArray (a,a) c+--  , coaxStackOpen :: PrimArray (a,b,b) c+--  , coaxStackCont :: PrimArray (a,b,b) c+  , largeLoop :: Double+  , termAU :: c+  , intermolecularInit :: c+  }++++-- | Map functions over the payload.++dmap f Turner2004{..} = Turner2004+  { stack = amap f stack+  , dangle3 = amap f dangle3+  , dangle5 = amap f dangle5+  , hairpinL = amap f hairpinL+  , hairpinMM = amap f hairpinMM+  , hairpinLookup = fmap f hairpinLookup+--  , hairpinGGG = f hairpinGGG+--  , hairpinCslope = f hairpinCslope+--  , hairpinCintercept = f hairpinCintercept+--  , hairpinC3 = f hairpinC3+  , bulgeL = amap f bulgeL+--  , bulgeSingleC = f bulgeSingleC+  , iloop1x1 = amap f iloop1x1+  , iloop1x2 = amap f iloop1x2+  , iloop2x2 = amap f iloop2x2+  , iloopMM = amap f iloopMM+  , iloop2x3MM = amap f iloop2x3MM+  , iloop1xnMM = amap f iloop1xnMM+  , iloopL = amap f iloopL+  , multiMM = amap f multiMM+  , ninio = f ninio+  , maxNinio = f maxNinio+  , multiOffset = f multiOffset+  , multiNuc = f multiNuc+  , multiHelix = f multiHelix+--  , multiAsym = f multiAsym+--  , multiStrain = f multiStrain+  , extMM = amap f extMM+--  , coaxStack = amap f coaxStack+--  , coaxStackOpen = amap f coaxStackOpen+--  , coaxStackCont = amap f coaxStackCont+  , largeLoop = largeLoop+  , termAU = f termAU+  , intermolecularInit = f intermolecularInit+  }++++-- | Zip two payloads.+--+-- TODO right now, we have undefined behaviour when some arrrays are of different length++dZipWith f t1 t2 = Turner2004+  { stack = zipWithPA f (stack t1) (stack t2)+  , dangle3 = zipWithPA f (dangle3 t1) (dangle3 t2)+  , dangle5 = zipWithPA f (dangle5 t1) (dangle5 t2)+  , hairpinL = zipWithPA f (hairpinL t1) (hairpinL t2)+  , hairpinMM = zipWithPA f (hairpinMM t1) (hairpinMM t2)+  , hairpinLookup = undefined -- zipWithPA f (hairpinLookup t1) (hairpinLookup t2)+  , bulgeL = zipWithPA f (bulgeL t1) (bulgeL t2)+  , iloop1x1 = zipWithPA f (iloop1x1 t1) (iloop1x1 t2)+  , iloop1x2 = zipWithPA f (iloop1x2 t1) (iloop1x2 t2)+  , iloop2x2 = zipWithPA f (iloop2x2 t1) (iloop2x2 t2)+  , iloopMM = zipWithPA f (iloopMM t1) (iloopMM t2)+  , iloop2x3MM = zipWithPA f (iloop2x3MM t1) (iloop2x3MM t2)+  , iloop1xnMM = zipWithPA f (iloop1xnMM t1) (iloop1xnMM t2)+  , iloopL = zipWithPA f (iloopL t1) (iloopL t2)+  , multiMM = zipWithPA f (multiMM t1) (multiMM t2)+  , ninio = f (ninio t1) (ninio t2)+  , maxNinio = f (maxNinio t1) (maxNinio t2)+  , multiOffset = f (multiOffset t1) (multiOffset t2)+  , multiNuc = f (multiNuc t1) (multiNuc t2)+  , multiHelix = f (multiHelix t1) (multiHelix t2)+  , extMM = zipWithPA f (extMM t1) (extMM t2)+  , largeLoop = largeLoop t1 -- no zipping here! TODO make this a constant somewhere!+  , termAU = f (termAU t1) (termAU t2)+  , intermolecularInit = f (intermolecularInit t1) (intermolecularInit t2)+  }++zipWithPA f a1 a2 = let (l,u) = bounds a1 in fromList l u $ zipWith f (toList a1) (toList a2)

@@ -0,0 +1,36 @@+{-# LANGUAGE MultiParamTypeClasses #-}++-- | Provides a converting function between different types. Most useful+-- conversions are instanced here.++module Biobase.Types.Convert where++import Biobase.Types.Ring+import Biobase.Types.Energy+import Biobase.Types.Score+import Biobase.Types.Partition++++-- | How to convert between different values.++class Convert a b c where+  convert :: a -> b -> c++++-- | From (Gibbs free) energy to partition function values.+--+-- TODO temperature is running around here: move to some library later on++newtype Kelvin = Kelvin {unKelvin :: Double}++constR = undefined++instance Convert Kelvin Energy Partition where+  convert (Kelvin k) (Energy a) = Partition . exp $ (fromIntegral $ negate a) / (constR * k)++-- | From log-odd scores to partition function.++-- instance Convert Temperature Score Partition where+--   convert (Score a) = Partition . exp $ (fromIntegral $ neg a) / (constR * constT)

@@ -0,0 +1,51 @@+{-# LANGUAGE StandaloneDeriving #-}+{-# LANGUAGE MultiParamTypeClasses #-}+{-# LANGUAGE GeneralizedNewtypeDeriving #-}++module Biobase.Types.Energy where++import qualified Data.Vector.Unboxed as VU+import qualified Data.Vector.Generic as VG+import qualified Data.Vector.Generic.Mutable as VGM+import Data.Primitive.Types++import Biobase.Types.Ring++++-- | Some default instances. Left out the Num one, so that you have to+-- explicitly instanciate if you want to go around the Ring structure.++newtype Energy = Energy {unEnergy :: Int}+  deriving (Show, Read, Eq, Ord)++++-- | Ring operations over Energy values.++instance Ring Energy where+  (Energy a) .+. (Energy b) = Energy $ a `min` b+  {-# INLINE (.+.) #-}+  (Energy a) .*. (Energy b) = Energy $ a + b+  {-# INLINE (.*.) #-}+  (Energy a) .^. k = Energy $ a * k+  {-# INLINE (.^.) #-}+  (Energy a) .^^. k = Energy . round $ fromIntegral a * k+  {-# INLINE (.^^.) #-}+  neg (Energy a) = Energy $ negate a+  {-# INLINE neg #-}+  one = Energy 0+  {-# INLINE one #-}+  zero = Energy 10000000+  {-# INLINE zero #-}+  isZero (Energy a) = a >= 1000000+  {-# INLINE isZero #-}++++-- * Vector instances.++deriving instance VGM.MVector VU.MVector Energy+deriving instance VG.Vector VU.Vector Energy+deriving instance VU.Unbox Energy+deriving instance Prim Energy

@@ -0,0 +1,84 @@++{-# LANGUAGE ForeignFunctionInterface #-}+{-# LANGUAGE StandaloneDeriving #-}+{-# LANGUAGE MultiParamTypeClasses #-}+{-# LANGUAGE GeneralizedNewtypeDeriving #-}++module Biobase.Types.Partition where++import qualified Data.Vector.Unboxed as VU+import qualified Data.Vector.Generic as VG+import qualified Data.Vector.Generic.Mutable as VGM+import Data.Primitive.Types++import Biobase.Types.Ring++++-- | Some default instances. Left out the Num one, so that you have to+-- explicitly instanciate if you want to go around the Ring structure.++newtype Partition = Partition {unPartition' :: Double}+  deriving (Show, Read, Eq, Ord)++-- |++mkPartition :: Double -> Partition+mkPartition x+  | x < 0     = error $ "mkPartition: prob <0: " ++ show x+  | x > 1     = error $ "mkPartition: prob >1: " ++ show x+  | otherwise = Partition $ log x++unPartition :: Partition -> Double+unPartition (Partition x) = exp x+++-- | Ring operations over Partition values.++instance Ring Partition where+  (Partition a) .+. (Partition b) = Partition $ logSum a b+  {-# INLINE (.+.) #-}+  (Partition a) .*. (Partition b) = Partition $ a + b+  {-# INLINE (.*.) #-}+  (Partition a) .^. k = Partition $ a * fromIntegral k+  {-# INLINE (.^.) #-}+  (Partition a) .^^. k = error ".^^. not defined for Partition" -- Partition $ a ^^ k+  {-# INLINE (.^^.) #-}+  neg (Partition a) = error $ "negate partition? " ++ show a -- Partition $ negate a+  {-# INLINE neg #-}+  one = Partition 1+  {-# INLINE one #-}+  zero = Partition 0+  {-# INLINE zero #-}+  isZero (Partition a) = a == 0 -- TODO use some epsilon?+  {-# INLINE isZero #-}++logSum :: Double -> Double -> Double+logSum a b+  | a>b       = f a b+  | otherwise = f b a+  where+    f x y = x + log1p (exp $ y - x)+    {-# INLINE f #-}+{-# INLINE logSum #-}++++-- * Vector (and Prim) instances.++deriving instance VGM.MVector VU.MVector Partition+deriving instance VG.Vector VU.Vector Partition+deriving instance VU.Unbox Partition+deriving instance Prim Partition++++-- * math.h function for log/exp on pm1 are /much/ more efficient (what is+-- haskell doing?)++foreign import ccall unsafe "math.h log1p"+    log1p :: Double -> Double++foreign import ccall unsafe "math.h expm1"+    expm1 :: Double -> Double+

@@ -0,0 +1,22 @@++-- | Algebraic ring structure. Very similar to others found throughout hackage.+--+-- TODO maybe use on of the already-written packages?++module Biobase.Types.Ring where++++-- | Define the basic operations on a ring.++class (Eq a, Ord a) => Ring a where+  (.+.), (.*.) :: a -> a -> a+  (.^.) :: a -> Int -> a+  (.^^.) :: a -> Double -> a+  neg :: a -> a+  one, zero :: a+  isZero :: a -> Bool -- ^ ==zero does not work well for min-plus+  infixl 6 .+.+  infixl 7 .*.+  infixr 8 .^.+  infixr 8 .^^.

@@ -0,0 +1,48 @@++{-# LANGUAGE StandaloneDeriving #-}+{-# LANGUAGE MultiParamTypeClasses #-}+{-# LANGUAGE GeneralizedNewtypeDeriving #-}++module Biobase.Types.Score where++import qualified Data.Vector.Unboxed as VU+import qualified Data.Vector.Generic as VG+import qualified Data.Vector.Generic.Mutable as VGM+import Data.Primitive.Types++import Biobase.Types.Ring++++-- | Some default instances. Left out the Num one, so that you have to+-- explicitly instanciate if you want to go around the Ring structure.++newtype Score = Score {unScore :: Int}+  deriving (Show, Read, Eq, Ord)++++-- | Ring operations over Score values.++instance Ring Score where+  (Score a) .+. (Score b) = Score $ a `min` b+  {-# INLINE (.+.) #-}+  (Score a) .*. (Score b) = Score $ a + b+  {-# INLINE (.*.) #-}+  neg (Score a) = Score $ negate a+  {-# INLINE neg #-}+  one = Score 0+  {-# INLINE one #-}+  zero = Score 10000000+  {-# INLINE zero #-}+  isZero (Score a) = a >= 1000000+  {-# INLINE isZero #-}++++-- * Vector instances.++deriving instance VGM.MVector VU.MVector Score+deriving instance VG.Vector VU.Vector Score+deriving instance VU.Unbox Score+deriving instance Prim Score

@@ -0,0 +1,89 @@+{-# LANGUAGE NoMonomorphismRestriction #-}++-- | Turner energy data as used in the ViennaRNA package.+--+-- TODO should use energy type for tables, not int!++module Biobase.Vienna where++import Data.Map (Map,empty)++import Data.Ix.Tuple+import Data.PrimitiveArray.Ix+import Data.PrimitiveArray+import Biobase.Types.Partition+import Biobase.Types.Energy++import Biobase.RNA+import Biobase.Turner.Tables+import Biobase.Constants++++-- Type for Vienna Tables++-- type ViennaEnergySet = (Temperature, ViennaTables, ViennaTables)++type ViennaIntTables = Turner2004 ViennaPair Nucleotide Int+type ViennaEnergyTables = Turner2004 ViennaPair Nucleotide Energy+type ViennaPartitionTables = Turner2004 ViennaPair Nucleotide Partition++type Temperature = Double++++-- | An empty Turner2004 set, with Vienna-style keys for tables. Unused fields+-- are commented out. Activate them in BiobaseTurner before doing the same+-- here!++emptyTables :: ViennaIntTables+emptyTables = Turner2004+  --stack+  { stack = emptyIV+  --dangle+  , dangle3 = emptyIV+  , dangle5 = emptyIV+  --hairpin+  , hairpinL = emptyV+  , hairpinMM = emptyIV+  , hairpinLookup = empty+  --eInf+  --eInf+  --eInf+  --eInf+  --bulge+  , bulgeL = emptyV+  --eInf+  --internal+  , iloop1x1 = emptyIV+  , iloop1x2 = emptyIV+  , iloop2x2 = emptyIV+  , iloopMM = emptyIV+  , iloop2x3MM = emptyIV+  , iloop1xnMM = emptyIV+  , iloopL = emptyV+  --multibranch+  , multiMM = emptyIV+  , ninio = eInf+  , maxNinio = eInf+  , multiOffset = eInf+  , multiNuc = eInf+  , multiHelix = eInf+  --eInf+  --eInf+  --exterior+  , extMM = emptyIV+  --coaxial stacking+  --emptyIV+  --emptyIV+  --emptyIV+  --scalar values+  , largeLoop = fInf -- large loop is always double+  , termAU = eInf+  , intermolecularInit = eInf+  }++emptyIV = fromAssocs minBound maxBound eInf []++-- TODO should be an empty a+emptyV = fromAssocs 0 30 eInf []

@@ -0,0 +1,27 @@++{-# LANGUAGE TemplateHaskell #-}++-- | Embedding of a default set of parameters. These are encoded in Vienna style and+-- use the Turner2004 set of parameters.++module Biobase.Vienna.Default+  ( turner2004GH+  ) where++import Data.FileEmbed+import qualified Data.ByteString.Char8 as B++import Biobase.Vienna.Import.ViennaPar+import Biobase.Turner.Tables+import Biobase.Vienna+import Biobase.Types.Energy++++defaultPars :: B.ByteString+defaultPars = $(embedFile "parfiles/Turner2004GH.par")++-- Turner entropy and enthalpy tables.++turner2004GH = (dmap Energy ta,dmap Energy tb) where+  (ta,tb) = importPar $ B.unpack defaultPars

@@ -0,0 +1,264 @@+{-# LANGUAGE ScopedTypeVariables #-}+{-# LANGUAGE TemplateHaskell #-}++-- | Exports the Vienna energy tables as a number of C files (one .c file, a+-- number .h files). For this reason, files are written into a target+-- directory!++module Biobase.Vienna.Export.ViennaC+  ( export+  ) where++import Prelude hiding (pi)+import Text.Printf+import System.Directory+import Data.List.Split+import Data.List+import qualified Data.Map as M+import Data.FileEmbed+import qualified Data.ByteString.Char8 as B++import Biobase.Turner.Tables+import Biobase.Vienna+import Data.PrimitiveArray+import Biobase.RNA++import Biobase.Vienna.Default++(g,h) = turner2004GH++++type Directory = FilePath++-- | Export the files required for default values in the ViennaRNA 2.0 C+-- package.++export :: ViennaIntTables -> ViennaIntTables -> Directory -> IO ()+export trnrG trnrH target = mapM_ (\f -> f trnrG trnrH target) [exportC, export11, export21, export22]++++-- | Export the main C file++exportC :: ViennaIntTables -> ViennaIntTables -> Directory -> IO ()+exportC trnrG trnrH target = writeFile (target ++ "/energy_par.c") out where+  out = unlines [ B.unpack $(embedFile "templates/cheader") , xs, stck, lps, mms, dngls, tris, tets, hexs,includes]+  xs = unlines+        [ pd "lxc37" $ largeLoop trnrG+        , pi "ML_intern37" $ multiHelix trnrG+        , pi "ML_interndH" $ multiHelix trnrH+        , pi "ML_closing37" $ multiOffset trnrG+        , pi "ML_closingdH" $ multiOffset trnrH+        , pi "ML_BASE37" $ multiNuc trnrG+        , pi "ML_BASEdH" $ multiNuc trnrH+        , pi "MAX_NINIO" $ maxNinio trnrG+        , pi "ninio37" $ ninio trnrG+        , pi "niniodH" $ ninio trnrH+        , pi "TerminalAU37" $ termAU trnrG+        , pi "TerminalAUdH" $ termAU trnrH+        , pi "DuplexInit37" $ intermolecularInit trnrG+        , pi "DuplexInitdH" $ intermolecularInit trnrH+        , pi "TripleC37" 100+        , pi "TripleCdH" 1860+        , pi "MultipleCA37" 30+        , pi "MultipleCAdH" 340+        , pi "MultipleCB37" 160+        , pi "MultipleCBdH" 760+        ]+  stck = unlines+          [ "PUBLIC int stack37[NBPAIRS+1][NBPAIRS+1] ="+          , (block2 8 . toList $ stack trnrG)+          , "PUBLIC int stackdH[NBPAIRS+1][NBPAIRS+1] ="+          , (block2 8 . toList $ stack trnrH)+          ]+  lps = unlines+          [ "PUBLIC int hairpin37[31] = {" ++ (concat . intersperse "," . map printNum . toList $ hairpinL trnrG) ++ "};"+          , "PUBLIC int hairpindH[31] = {" ++ (concat . intersperse "," . map printNum . toList $ hairpinL trnrH) ++ "};"+          , "PUBLIC int bulge37[31] = {" ++ (concat . intersperse "," . map printNum . toList $ bulgeL trnrG) ++ "};"+          , "PUBLIC int bulgedH[31] = {" ++ (concat . intersperse "," . map printNum . toList $ bulgeL trnrH) ++ "};"+          , "PUBLIC int internal_loop37[31] = {" ++ (concat . intersperse "," . map printNum . toList $ iloopL trnrG) ++ "};"+          , "PUBLIC int internal_loopdH[31] = {" ++ (concat . intersperse "," . map printNum . toList $ iloopL trnrH) ++ "};"+          ]+  mms = unlines+          [ writeMM "I" iloopMM trnrG trnrH+          , writeMM "H" hairpinMM trnrG trnrH+          , writeMM "M" multiMM trnrG trnrH+          , writeMM "1nI" iloop1xnMM trnrG trnrH+          , writeMM "23I" iloop2x3MM trnrG trnrH+          , writeMM "Ext" extMM trnrG trnrH+          ]+  dngls = unlines+            [ "PUBLIC int dangle3_37[NBPAIRS+1][5] ="+            , block2 5 . toList $ dangle3 trnrG+            , "PUBLIC int dangle3_dH[NBPAIRS+1][5] ="+            , block2 5 . toList $ dangle3 trnrH+            , "PUBLIC int dangle5_37[NBPAIRS+1][5] ="+            , block2 5 . toList $ dangle5 trnrG+            , "PUBLIC int dangle5_dH[NBPAIRS+1][5] ="+            , block2 5 . toList $ dangle5 trnrH+            ]+  t3 = getLookup 3 trnrG trnrH+  t4 = getLookup 4 trnrG trnrH+  t6 = getLookup 6 trnrG trnrH+  tris = writeTabbed 3 "Triloop" t3+  tets = writeTabbed 4 "Tetraloop" t4+  hexs = writeTabbed 6 "Hexaloop" t6++  includes = unlines $ map ((++ "\"") . ("#include \""++))+    [ "intl11.h"+    , "intl11dH.h"+    , "intl21.h"+    , "intl21dH.h"+    , "intl22.h"+    , "intl22dH.h"+    ]++++-- | Export iloops 1x1++export11 :: ViennaIntTables -> ViennaIntTables -> Directory -> IO ()+export11 trnrG trnrH target = writeFile (target ++ "/intl11.h") outG >> writeFile (target ++ "/intl11dH.h") outH where+  outG = unlines+    [ "PUBLIC int int11_37[NBPAIRS+1][NBPAIRS+1][5][5] ="+    , (block4 8 5 5 . toList $ iloop1x1 trnrG)+    ]+  outH = unlines+    [ "PUBLIC int int11_dH[NBPAIRS+1][NBPAIRS+1][5][5] ="+    , (block4 8 5 5 . toList $ iloop1x1 trnrH)+    ]++++-- | Export iloops 2x1++export21 :: ViennaIntTables -> ViennaIntTables -> Directory -> IO ()+export21 trnrG trnrH target = writeFile (target ++ "/intl21.h") outG >> writeFile (target ++ "/intl21dH.h") outH where+  outG = unlines+    [ "PUBLIC int int21_37[NBPAIRS+1][NBPAIRS+1][5][5][5] ="+    , (block5 8 5 5 5 . toList $ iloop1x2 trnrG)+    ]+  outH = unlines+    [ "PUBLIC int int21_dH[NBPAIRS+1][NBPAIRS+1][5][5][5] ="+    , (block5 8 5 5 5 . toList $ iloop1x2 trnrH)+    ]++++-- | Export iloops 2x2++export22 :: ViennaIntTables -> ViennaIntTables -> Directory -> IO ()+export22 trnrG trnrH target =  writeFile (target ++ "/intl22.h") outG >> writeFile (target ++ "/intl22dH.h") outH where+  outG = unlines+    [ "PUBLIC int int22_37[NBPAIRS+1][NBPAIRS+1][5][5][5][5] ="+    , (block6 8 5 5 5 5 . toList $ iloop2x2 trnrG)+    ]+  outH = unlines+    [ "PUBLIC int int22_dH[NBPAIRS+1][NBPAIRS+1][5][5][5][5] ="+    , (block6 8 5 5 5 5 . toList $ iloop2x2 trnrH)+    ]++++-- * Helper functions++writeTabbed (ksize :: Int) key (ns,gs,hs) =  unlines+          [ printf "PUBLIC char %ss[%d] =" key ((ksize+3)*40+1)+          , ns+          , ";"+          ] ++ printf "PUBLIC int %s37[40] = " key ++ gs ++ ";\n"+          ++ printf "PUBLIC int %sdH[40] = " key ++ hs ++ ";\n"++getLookup k trnrG trnrH = (nsF,gs,hs) where+  nsF = concat $ intersperse "\n" $ map ((++ " \"") . ("  \"" ++) . map nucleotideToChar) ns+  ns = filter ((==(k+2)) . length) . M.keys $ hairpinLookup trnrG+  gs = lkup trnrG+  hs = lkup trnrH+  lkup tbl = ("{"++) . (++"}") . concat . intersperse "," $ map (printNum . (hairpinLookup tbl M.!)) ns++writeMM typ fun trnrG trnrH = unlines+          [ printf "PUBLIC int mismatch%s37[NBPAIRS+1][5][5] =" typ+          , block3 5 5 . toList $ fun trnrG+          , printf "PUBLIC int mismatch%sdH[NBPAIRS+1][5][5] =" typ+          , block3 5 5 . toList $ fun trnrH+          ]++block2 s2 xs+  = (++ "};")+  . ("{" ++)+  . concat+  . intersperse "\n,"+  . map ((++ "}") . ("{" ++) . concat . intersperse ",")+  . splitEvery s2+  $ map printNum xs++block3 s2 s3 xs+  = (++ "};")+  . ("{" ++)+  . concat+  . intersperse "\n,"+  . map ((++ "}") . ("{" ++) . concat . intersperse ",")+  . splitEvery s2+  . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s3+  $ map printNum xs++block4 s2 s3 s4 xs+  = (++ "};")+  . ("{" ++)+  . concat+  . intersperse "\n,"+  . map ((++ "}") . ("{" ++) . concat . intersperse ",")+  . splitEvery s2+  . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s3+  . map ((++ "}\n  ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s4+  $ map printNum xs++block5 s2 s3 s4 s5 xs+  = (++ "};")+  . ("{" ++)+  . concat+  . intersperse "\n,"+  . map ((++ "}") . ("{" ++) . concat . intersperse ",")+  . splitEvery s2+  . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s3+  . map ((++ "}\n  ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s4+  . map ((++ "}\n   ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s5+  $ map printNum xs++block6 s2 s3 s4 s5 s6 xs+  = (++ "};")+  . ("{" ++)+  . concat+  . intersperse "\n,"+  . map ((++ "}") . ("{" ++) . concat . intersperse ",")+  . splitEvery s2+  . map ((++ "}\n ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s3+  . map ((++ "}\n  ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s4+  . map ((++ "}\n   ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s5+  . map ((++ "}\n    ") . ("{" ++) . concat . intersperse ",")+  . splitEvery s6+  $ map printNum xs+++pd :: String -> Double -> String+pd k v = printf "PUBLIC double %s=%f;" k v++pi :: String -> Int -> String+pi k v = printf "PUBLIC int %s=%d;" k v++printNum :: Int -> String+printNum n+  | n >= maxN = "   INF"+  | otherwise = printf "%6d" n+  where+    maxN = 10000

@@ -0,0 +1,139 @@++{-# LANGUAGE NoMonomorphismRestriction #-}++module Biobase.Vienna.Export.ViennaPar+  ( export+  ) where++import Data.Tuple.Select+import Data.List.Split+import Text.Printf+import Control.Arrow+import Data.List (intersperse)+import qualified Data.Map as M++import Data.PrimitiveArray+import Biobase.Turner.Tables+import Biobase.RNA+import Biobase.Constants++import Biobase.Vienna++++export :: ViennaIntTables -> ViennaIntTables -> String+export trnr trnrH = hdr ++ blocks ++ mlps ++ ninios ++ misc ++ triloops ++ tetra ++ hexa ++ "\n#END" where+  hdr = "## RNAfold parameter file v2.0\n\n"+  mlps = printf "# ML_params\n%7d %7d %7d %7d %7d %7d\n\n"+    (multiNuc trnr) (multiNuc trnrH)+    (multiOffset trnr) (multiOffset trnrH)+    (multiHelix trnr) (multiHelix trnrH)+  ninios = printf "# NINIO\n%7d %7d %7d\n\n"+    (ninio trnr) (ninio trnrH) (maxNinio trnr)+  misc = printf "# Misc\n %7d %7d %7d %7d\n\n"+    (intermolecularInit trnr) (intermolecularInit trnrH) (termAU trnr) (termAU trnrH)+  triloops = "# Triloops\n" ++ printHairpinAssocs 5 trnr trnrH ++ "\n"+  tetra = "# Tetraloops\n" ++ printHairpinAssocs 6 trnr trnrH ++ "\n"+  hexa = "# Hexaloops\n" ++ printHairpinAssocs 8 trnr trnrH ++ "\n"+  blocks = concat $ zipWith (++)+    -- entropy terms+    [ printBlock "stack"                7 pp2lkey     $ stack trnr+    , printBlock "mismatch_hairpin"     5 pbb2lkey    $ hairpinMM trnr+    , printBlock "mismatch_interior"    5 pbb2lkey    $ iloopMM trnr+    , printBlock "mismatch_interior_1n" 5 pbb2lkey    $ iloop1xnMM trnr+    , printBlock "mismatch_interior_23" 5 pbb2lkey    $ iloop2x3MM trnr+    , printBlock "mismatch_multi"       5 pbb2lkey    $ multiMM trnr+    , printBlock "mismatch_exterior"    5 pbb2lkey    $ extMM trnr+    , printBlock "dangle5"              5 pb2lkey     $ dangle5 trnr+    , printBlock "dangle3"              5 pb2lkey     $ dangle3 trnr+    , printBlock "int11"                5 ppbb2lkey   $ iloop1x1 trnr+    , printBlock "int21"                5 ppbbb2lkey  $ iloop1x2 trnr+    , printBlock22 "int22"              4 ppbbbb2lkey $ iloop2x2 trnr+    , printLinear "hairpin"            10             $ hairpinL trnr+    , printLinear "bulge"              10             $ bulgeL trnr+    , printLinear "interior"           10             $ iloopL trnr+    ]+    -- enthalpy terms+    [ printBlockH "stack"                7 pp2lkey     $ stack trnrH+    , printBlockH "mismatch_hairpin"     5 pbb2lkey    $ hairpinMM trnrH+    , printBlockH "mismatch_interior"    5 pbb2lkey    $ iloopMM trnrH+    , printBlockH "mismatch_interior_1n" 5 pbb2lkey    $ iloop1xnMM trnrH+    , printBlockH "mismatch_interior_23" 5 pbb2lkey    $ iloop2x3MM trnrH+    , printBlockH "mismatch_multi"       5 pbb2lkey    $ multiMM trnrH+    , printBlockH "mismatch_exterior"    5 pbb2lkey    $ extMM trnrH+    , printBlockH "dangle5"              5 pb2lkey     $ dangle5 trnrH+    , printBlockH "dangle3"              5 pb2lkey     $ dangle3 trnrH+    , printBlockH "int11"                5 ppbb2lkey   $ iloop1x1 trnrH+    , printBlockH "int21"                5 ppbbb2lkey  $ iloop1x2 trnrH+    , printBlock22H "int22"              4 ppbbbb2lkey $ iloop2x2 trnrH+    , printLinearH "hairpin"            10             $ hairpinL trnrH+    , printLinearH "bulge"              10             $ bulgeL trnrH+    , printLinearH "interior"           10             $ iloopL trnrH+    ]++++-- * Helper functions++-- | Show the key of the line, minus the changing last key++showKey :: [(LKey,Int)] -> String+showKey xs =+  "   /* " +++  (concat $ intersperse "," $ init $ (map show ps) ++ (map show ns)) +++  " */"+  where+    (ps,ns) = fst $ head xs++-- | Transform from tuple-based keys to a pair of list-based keys.++type LKey = ([ViennaPair],[Nucleotide])++pb2lkey (p1,b1) = ([p1],[b1])+pbb2lkey (p1,b1,b2) = ([p1],[b1,b2])+pp2lkey (k1,k2) = ([k1,k2],[])+ppbb2lkey (p1,p2,b1,b2) = ([p1,p2],[b1,b2])+ppbbb2lkey (p1,p2,b1,b2,b3) = ([p1,p2],[b1,b2,b3])+ppbbbb2lkey (p1,p2,b1,b2,b3,b4) = ([p1,p2],[b1,b2,b3,b4])++-- | Print a block.++printBlock = printBlockG noNP where+  noNP ((ps,ns),v) = not $ any (==vpNP) ps++printBlockH s = printBlock (s ++ "_enthalpies")++printBlock22 = printBlockG noNSNPE where+  noNSNPE ((ps,ns),v) = not $ any (==vpNP) ps || any (==vpNS) ps || any (==nucE) ns++printBlock22H s = printBlock22 (s ++ "_enthalpies")++printBlockG fltr s k tolkey xs' =+  let+    xs = filter fltr $ map (first tolkey)  $ assocs xs'+  in+    printf "# %s\n" s +++    (concatMap printLine $ splitEvery k xs) +++    "\n"++printLine xs =+  concatMap printVal xs ++ " " ++ showKey xs +++  printf "\n"++printVal (k,v)+  | v > eMax = printf "   INF"+  | otherwise = printf "%6d" v++-- | A linear block is more boring++printLinear s k xs' = let xs = assocs xs' in+    printf "# %s\n" s +++    (concatMap (\ys -> concatMap printVal ys ++ "\n") $ splitEvery k xs) +++    "\n"++printHairpinAssocs l trnr trnrH = res where+  res = concat $ zipWith (\(k,v) vH -> printf "%s %7d %7d\n" (concatMap show k) v vH) xs ys+  xs = filter ((==l).length.fst) $ M.assocs $ hairpinLookup trnr+  ys = map snd $ filter ((==l).length.fst) $ M.assocs $ hairpinLookup trnrH++printLinearH s = printLinear (s ++ "_enthalpies")

@@ -0,0 +1,71 @@+{-# LANGUAGE RecordWildCards #-}++-- | Import data from a Turner table structure. Those can be imported using the+-- Turner.Import module.++module Biobase.Vienna.Import.Turner+  ( fromTurner+  ) where++import Control.Arrow+import Data.Tuple.All+import qualified Data.Map as M++import Biobase.Turner.Tables+import Biobase.Turner+import Data.PrimitiveArray+import Biobase.Constants+import Biobase.RNA++import Biobase.Vienna+-- | Convert from Turner keys to Vienna keys and all values from Double to Int++fromTurner :: TurnerTables -> ViennaIntTables+fromTurner Turner2004{..} = Turner2004+  { stack = convert pp stack+  , dangle3 = convert pb dangle3+  , dangle5 = convert pb dangle5+  , hairpinL = amap f2i hairpinL+  , hairpinMM = convert pbb hairpinMM+  , hairpinLookup = M.map f2i hairpinLookup+  , bulgeL = amap f2i bulgeL+  , iloop1x1 = convert uu iloop1x1+  , iloop1x2 = convert uu iloop1x2+  , iloop2x2 = convert uu iloop2x2+  , iloopMM = convert pbb iloopMM+  , iloop2x3MM = convert pbb iloop2x3MM+  , iloop1xnMM = convert pbb iloop1xnMM+  , iloopL = amap f2i iloopL+  , multiMM = convert pbb multiMM+  , ninio = f2i ninio+  , maxNinio = f2i maxNinio+  , multiOffset = f2i multiOffset+  , multiNuc = f2i multiNuc+  , multiHelix = f2i multiHelix+  , extMM = convert pbb extMM+  , largeLoop = largeLoop * 100 -- scale to decacals+  , termAU = f2i termAU+  , intermolecularInit = f2i intermolecularInit+  }++++-- * Helper functions.++-- | Vienna values are Int's that have 2-digit precision.++f2i :: Double -> Int+f2i d = round $ d * 100+++-- | Deep breath ;-)++pp = both tuple2Vienna+pb = first tuple2Vienna+pbb t = upd1 (tuple2Vienna $ sel1 t) t+uu t = upd2 (tuple2Vienna $ sel2 t) $ upd1 (tuple2Vienna $ sel1 t) t+both f = first f . second f++-- | Do the conversion, both on keys and values.++convert fk = fromAssocs minBound maxBound eInf . map (first fk . second f2i) . assocs

@@ -0,0 +1,123 @@+{-# LANGUAGE PatternGuards #-}+{-# LANGUAGE RecordWildCards #-}++module Biobase.Vienna.Import.ViennaPar+  ( importPar+  ) where++import Text.Parsec hiding ((<|>), many, optional)+import Text.Parsec.String+import Text.Parsec.Char+import Text.Parsec.Combinator hiding (optional)+import Control.Applicative+import Data.List+import qualified Data.Map as M++import Text.Parsec.Numbers+import Biobase.Constants+import Biobase.RNA+import Biobase.Turner.Tables+import Data.PrimitiveArray++import Biobase.Vienna++++-- | Imports Vienna tables from a given string.++importPar :: String -> (ViennaIntTables,ViennaIntTables)+importPar s+  | Right _  <- p = foldr updateTables (trnr,trnrH) bs+  | Left err <- p = error $ show err+  where+    p = parse blocks "(stdin)" s+    Right bs = p+    (bgs,bhs) = partition (not . isHblock) bs+    trnr  = foldr updateTable emptyTables bgs+    trnrH = foldr updateTable emptyTables bhs++-- | Apply all parsed blocks to a Turner2004 structure.++updateTable :: Block -> ViennaIntTables -> ViennaIntTables+updateTable Block{..} trnr -- @Turner2004{..}+  | bhdr =? "stack" = trnr{stack = fromAssocs minBound maxBound z $ zip pp ints}+  | bhdr =? "dangle3" = trnr{dangle3 = fromAssocs minBound maxBound z $ zip pb ints}+  | bhdr =? "dangle5" = trnr{dangle5 = fromAssocs minBound maxBound z $ zip pb ints}+  | bhdr =? "hairpin" = trnr{hairpinL = fromList 0 30 ints}+  | bhdr =? "mismatch_hairpin" = trnr{hairpinMM = fromAssocs minBound maxBound z $ zip pbb ints}+  | bhdr =? "bulge" = trnr{bulgeL = fromList 0 30 ints}+  | bhdr =? "int11" = trnr{iloop1x1 = fromAssocs minBound maxBound z $ zip ppbb ints}+  | bhdr =? "int21" = trnr{iloop1x2 = fromAssocs minBound maxBound z $ zip ppbbb ints}+  | bhdr =? "int22" = trnr{iloop2x2 = fromAssocs minBound maxBound z $ zip ppbbbb ints}+  | bhdr =? "mismatch_interior" = trnr{iloopMM = fromAssocs minBound maxBound z $ zip pbb ints}+  | bhdr =? "mismatch_interior_23" = trnr{iloop2x3MM = fromAssocs minBound maxBound z $ zip pbb ints}+  | bhdr =? "mismatch_interior_1n" = trnr{iloop1xnMM = fromAssocs minBound maxBound z $ zip pbb ints}+  | bhdr =? "interior" = trnr{iloopL = fromList 0 30 ints}+  | bhdr =? "mismatch_multi" = trnr{multiMM = fromAssocs minBound maxBound z $ zip pbb ints}+  | bhdr =? "mismatch_exterior" = trnr{extMM = fromAssocs minBound maxBound z $ zip pbb ints}+  | otherwise = trnr -- unknown block!+updateTable ABlock{..} trnr+  | otherwise = trnr -- CORRECT!++-- | update with info where no separation between G/H was done.++updateTables Block{..} (trnr,trnrH)+  | bhdr =? "ML_params"+  = ( trnr {multiNuc = ints!!0, multiOffset = ints!!2, multiHelix = ints!!4}+    , trnrH{multiNuc = ints!!1, multiOffset = ints!!3, multiHelix = ints!!5}+    )+  | bhdr =? "NINIO"+  = ( trnr  {ninio = ints!!0, maxNinio = ints!!2}+    , trnrH {ninio = ints!!1}+    )+  | bhdr =? "Misc"+  = ( trnr  {intermolecularInit = ints!!0, termAU = ints!!2}+    , trnrH {intermolecularInit = ints!!1, termAU = ints!!3}+    )+  | otherwise = (trnr,trnrH)+updateTables ABlock{..} (trnr,trnrH)+  | bhdr =? "Triloops" || bhdr =? "Tetraloops" || bhdr =? "Hexaloops"+  = ( trnr {hairpinLookup = hairpinLookup trnr `M.union` (M.fromList $ map (\(k,v,w) -> (s2ns k,v)) ascs)}+    , trnrH {hairpinLookup = hairpinLookup trnrH `M.union` (M.fromList $ map (\(k,v,w) -> (s2ns k,w)) ascs)}+    )+  | otherwise = (trnr,trnrH)++pp = [(x,y) | x<-cgnsP,y<-cgnsP]+pb = [(x,y) | x<-cgnsP,y<-eacgu]+pbb = [(x,y,z) | x<-cgnsP,y<-eacgu,z<-eacgu]+ppbb = [(p1,p2,b1,b2) | p1<-cgnsP,p2<-cgnsP,b1<-eacgu,b2<-eacgu]+ppbbb = [(p1,p2,b1,b2,b3) | p1<-cgnsP,p2<-cgnsP,b1<-eacgu,b2<-eacgu,b3<-eacgu]+ppbbbb = [(p1,p2,b1,b2,b3,b4) | p1<-cguaP,p2<-cguaP,b1<-acgu,b2<-acgu,b3<-acgu,b4<-acgu]+z = eInf+-- xs is the block header name, ys the constant string+xs =? ys = xs == ys || xs == ys++"_enthalpies" -- and $ zipWith (==) xs ys+s2ns = map charToNucleotide++-- * Simple parser for the vienna 2.0 format.++isHblock :: Block -> Bool+isHblock b = "enthalpies" `elem` (tails $ bhdr b)++data Block+  = Block {bhdr :: String, ints :: [Int]}+  | ABlock {bhdr :: String, ascs :: [(String,Int,Int)]}+  deriving (Show)++blocks :: GenParser Char st [Block]+blocks = vrna2 *> spaces *> (try assocBlock <|> try block) `sepEndBy1` spaces <* string "#END" <* spaces <* eof++vrna2 = string "## RNAfold parameter file v2.0"++block :: GenParser Char st Block+block = Block <$> header <* spaces <*> num `sepEndBy1` (try comment <|> spaces) where+  num = ((eInf <$ string "INF") <|> parseIntegral)++assocBlock :: GenParser Char st Block+assocBlock = ABlock <$> header <* spaces <*> asc `sepEndBy1` spaces where+  asc = (,,) <$> (many1 $ oneOf "ACGU") <* spaces <*> parseIntegral <* spaces <*> parseIntegral++header :: GenParser Char st String+header = char '#' *> space *> (alphaNum <|> char '_') `manyTill` newline++comment :: GenParser Char st ()+comment = const () <$ spaces <*> between (string "/*") (string "*/") (many $ noneOf "/*") <* spaces

@@ -0,0 +1,121 @@++-- | This module provides facilities to modify values in the tables and return+-- the modified tables. The main reason for the modules' existence are the 'E'+-- nucleotides and 'NS' base pairs used by the ViennaRNA package to denote+-- unknown or missing nucleotides. For each table type, we have a small+-- function.++module Biobase.Vienna.Modification.NonStandard+  ( nonStandardMax+  ) where++import Biobase.RNA+import Biobase.Vienna+import Biobase.Turner.Tables+import Data.Ix.Tuple+import Biobase.Constants+import Biobase.Types.Energy++import Data.PrimitiveArray+++-- | Each table-changing operation makes the promise that all individual+-- changes in a batch are independent of the changes in the same batch++changeTable f tbl = fromAssocs l u z . map (f tbl) $ assocs tbl where+  (l,u) = bounds tbl+  z = Energy eInf++++-- |* Replace each occurrance of a value with a strange key according to this+-- rule. The rule is to take the maximum over all sane keys in the+-- neighborhood. Yes, this takes long...++fPPBBBBmax tbl (k@(p1,p2,b1,b2,b3,b4),v)+  | p1==vpNP || p2==vpNP = (k,v) -- don't do anything+  | otherwise = (k,maximum'+    [ tbl ! (p1n,p2n,b1n,b2n,b3n,b4n)+    | p1n <- genKeyP p1+    , p2n <- genKeyP p2+    , b1n <- genKeyB b1+    , b2n <- genKeyB b2+    , b3n <- genKeyB b3+    , b4n <- genKeyB b4+    ])++fPPBBBmax tbl (k@(p1,p2,b1,b2,b3),v)+  | p1==vpNP || p2==vpNP = (k,v)+  | otherwise = (k,maximum'+    [ tbl ! (p1n,p2n,b1n,b2n,b3n)+    | p1n <- genKeyP p1+    , p2n <- genKeyP p2+    , b1n <- genKeyB b1+    , b2n <- genKeyB b2+    , b3n <- genKeyB b3+    ])++fPPBBmax tbl (k@(p1,p2,b1,b2),v)+  | p1==vpNP || p2==vpNP = (k,v)+  | otherwise = (k,maximum'+    [ tbl ! (p1n,p2n,b1n,b2n)+    | p1n <- genKeyP p1+    , p2n <- genKeyP p2+    , b1n <- genKeyB b1+    , b2n <- genKeyB b2+    ])++fPPmax tbl (k@(p1,p2),v)+  | p1==vpNP || p2==vpNP = (k,v)+  | otherwise = (k,maximum'+    [ tbl ! (p1n,p2n)+    | p1n <- genKeyP p1+    , p2n <- genKeyP p2+    ])++fPBBmax tbl (k@(p1,b1,b2),v)+  | p1==vpNP = (k,v)+  | otherwise = (k,maximum'+    [ tbl ! (p1n,b1n,b2n)+    | p1n <- genKeyP p1+    , b1n <- genKeyB b1+    , b2n <- genKeyB b2+    ])++fPBmax tbl (k@(p1,b1),v)+  | p1==vpNP = (k,v)+  | otherwise = (k,maximum'+    [ tbl ! (p1n,b1n)+    | p1n <- genKeyP p1+    , b1n <- genKeyB b1+    ])++maximum' = Energy . maximum . map unEnergy+++-- * Generate keys. If the key is of the non-standard kind, then we go fishing,+-- otherwise we keep the key itself.++genKeyP k = if k==vpNS then cguaP else [k]+genKeyB k = if k==nucE then acgu else [k]++++-- | The max operation applied to all relevant tables. (This serves as a+-- pointer, which tables to manipulate).++nonStandardMax :: ViennaEnergyTables -> ViennaEnergyTables+nonStandardMax tbl = tbl+  { iloop1x1   = changeTable fPPBBmax   $ iloop1x1 tbl+  , iloop1x2   = changeTable fPPBBBmax  $ iloop1x2 tbl+  , iloop2x2   = changeTable fPPBBBBmax $ iloop2x2 tbl+  , hairpinMM  = changeTable fPBBmax    $ hairpinMM tbl+  , iloopMM    = changeTable fPBBmax    $ iloopMM tbl+  , iloop1xnMM = changeTable fPBBmax    $ iloop1xnMM tbl+  , iloop2x3MM = changeTable fPBBmax    $ iloop2x3MM tbl+  , multiMM    = changeTable fPBBmax    $ multiMM tbl+  , extMM      = changeTable fPBBmax    $ extMM tbl+  , dangle3    = changeTable fPBmax     $ dangle3 tbl+  , dangle5    = changeTable fPBmax     $ dangle5 tbl+  , stack      = changeTable fPPmax     $ stack tbl+  }

@@ -0,0 +1,51 @@++-- | Small module for converting Vienna energy tables to partition function+-- value tables.+--+-- Temperature scaling should happen on the level of energy tables, followed by+-- conversion here.+--+-- TODO after the switch to the Energy type, change too, the partitionTables+-- generation++module Biobase.Vienna.Modification.Partition+  ( partitionTables+  ) where++import Biobase.Types.Partition+import Biobase.Types.Energy+import Biobase.Turner.Tables+import Biobase.Vienna+import Biobase.Constants+++-- Testing++{-+import Biobase.Vienna.Default+import Data.PrimitiveArray+import Debug.Trace.Tools+import Biobase.RNA+import Biobase.Types.Ring++(g,h) = turner2004GH++-- x = toList $ stack $ partitionTables 37 g+x = {- toList $ -} (stack $ partitionTables 37 g) ! (vpGC,vpGC)+-}++-- | Create partition tables out of normal energy tables. Note that these+-- values are not normalized. An additional term 1/Z(1/kt) would be required+-- which is missing until we are done calculating the partition function.+--+-- All energy contributions are rescaled from dekacals back to kcal/mol.+--+-- We explicitly set all probabilities =0 where the energy is >= eMax.++partitionTables :: Temperature -> ViennaEnergyTables -> ViennaPartitionTables+partitionTables tempe trnr = dmap f trnr where+  kt = (tempe + kelvinC0) * gasconst+  -- convert energy into probability; encapsulate as a (logFloat) partition+  f (Energy e') = {- traceVal (show (e',e,p)) -} p where+    e = fromIntegral e' / 100+    p = if e' >= eMax then Partition 0 else Partition . exp $ -e / kt -- can NOT use mkPartition as these values are NOT NORMALIZED

@@ -0,0 +1,34 @@++-- | Given entropy and enthalpy sets, allow modification of the folding+-- temperature (from the default 37 Celsius)++module Biobase.Vienna.Modification.Temperature+  ( adjustTemperature+  ) where++import Biobase.Vienna+import Biobase.Turner.Tables+import Biobase.Constants++++-- temperature scaling is a generalized zip: let g and h be a scalar, t the+-- temperature. Then: g_t = h - (h-g)*((t+k_0)/t_m). Where k_0 = 273.15 (Kelvin+-- of 37 Celsius) and t_m = 37+k_0+--+-- TODO abstract over table type?+--+-- TODO this does not take into account that dangles are supposed to _always_+-- be beneficial. We should therefor transform the energies and then apply 'min+-- 0' onto all dangle types.+--+-- TODO use EnergyTables (Int is just for im-/export)++adjustTemperature :: ViennaIntTables -> ViennaIntTables -> Temperature -> ViennaIntTables+adjustTemperature trnrG trnrH cels = dZipWith f trnrG trnrH where+  f vG vH =+    let g = fromIntegral vG+        h = fromIntegral vH+        k_0 = kelvinC0+        t_m = 37 + k_0+    in  round $ h - (h-g) * ((cels+k_0)/t_m)

@@ -0,0 +1,8135 @@+## RNAfold parameter file v2.0++# stack+  -240  -330  -210  -140  -210  -210  -140    /* CG */+  -330  -340  -250  -150  -220  -240  -150    /* GC */+  -210  -250   130   -50  -140  -130   130    /* GU */+  -140  -150   -50    30   -60  -100    30    /* UG */+  -210  -220  -140   -60  -110   -90   -60    /* AU */+  -210  -240  -130  -100   -90  -130   -90    /* UA */+  -140  -150   130    30   -60   -90   130    /* NS */++# stack_enthalpies+ -1060 -1340 -1210  -560 -1050 -1040  -560    /* CG */+ -1340 -1490 -1260  -830 -1140 -1240  -830    /* GC */+ -1210 -1260 -1460 -1350  -880 -1280  -880    /* GU */+  -560  -830 -1350  -930  -320  -700  -320    /* UG */+ -1050 -1140  -880  -320  -940  -680  -320    /* AU */+ -1040 -1240 -1280  -700  -680  -770  -680    /* UA */+  -560  -830  -880  -320  -320  -680  -320    /* NS */++# mismatch_hairpin+   -80  -100  -110  -100   -80    /* CG,E */+  -140  -150  -150  -140  -150    /* CG,A */+   -80  -100  -110  -100   -80    /* CG,C */+  -150  -230  -150  -240  -150    /* CG,G */+  -100  -100  -140  -100  -210    /* CG,U */+   -50  -110   -70  -110   -50    /* GC,E */+  -110  -110  -150  -130  -150    /* GC,A */+   -50  -110   -70  -110   -50    /* GC,C */+  -150  -250  -150  -220  -150    /* GC,G */+  -100  -110  -100  -110  -160    /* GC,U */+    20    20   -20   -10   -20    /* GU,E */+    20    20   -50   -30   -50    /* GU,A */+   -10   -10   -20   -10   -20    /* GU,C */+   -50  -100   -50  -110   -50    /* GU,G */+   -10   -10   -30   -10  -100    /* GU,U */+     0   -20   -10   -20     0    /* UG,E */+   -30   -50   -30   -60   -30    /* UG,A */+     0   -20   -10   -20     0    /* UG,C */+   -30   -90   -30  -110   -30    /* UG,G */+   -10   -20   -10   -20   -90    /* UG,U */+   -10   -10   -20   -10   -20    /* AU,E */+   -30   -30   -50   -30   -50    /* AU,A */+   -10   -10   -20   -10   -20    /* AU,C */+   -50  -120   -50  -110   -50    /* AU,G */+   -10   -10   -30   -10  -120    /* AU,U */+     0   -20   -10   -20     0    /* UA,E */+   -30   -50   -30   -50   -30    /* UA,A */+     0   -20   -10   -20     0    /* UA,C */+   -30  -150   -30  -150   -30    /* UA,G */+   -10   -20   -10   -20   -90    /* UA,U */+    20    20   -10   -10     0    /* NS,E */+    20    20   -30   -30   -30    /* NS,A */+     0   -10   -10   -10     0    /* NS,C */+   -30   -90   -30  -110   -30    /* NS,G */+   -10   -10   -10   -10   -90    /* NS,U */++# mismatch_hairpin_enthalpies+   560  -570   560  -560  -270    /* CG,E */+  -560  -910  -560  -560  -560    /* CG,A */+  -270  -570  -340  -570  -270    /* CG,C */+   560 -1400   560  -920  -560    /* CG,G */+  -530  -570  -530  -570 -1440    /* CG,U */+    50  -520    50  -560  -400    /* GC,E */+  -400  -520  -400  -560  -400    /* GC,A */+    50  -720    50  -720  -420    /* GC,C */+  -400 -1290  -400  -620  -400    /* GC,G */+   -30  -720   -30  -720 -1080    /* GC,U */+   970   140   970   140   570    /* GU,E */+   570    30   570    20   570    /* GU,A */+   970   140   970   140   340    /* GU,C */+   570  -270   570    20   570    /* GU,G */+   830   140   830   140   -50    /* GU,U */+   230   100   230   220   190    /* UG,E */+  -110  -110  -260  -520  -260    /* UG,A */+   190   -60  -140   -60   190    /* UG,C */+   220   100  -260   220  -260    /* UG,G */+   230   -60   230   -60   -70    /* UG,U */+   970   140   970   140   570    /* AU,E */+   570   -20   570    20   570    /* AU,A */+   970   140   970   140   340    /* AU,C */+   570  -520   570    20   570    /* AU,G */+   830   140   830   140  -380    /* AU,U */+   230   -30   230   -60   190    /* UA,E */+   -30   -30  -260  -520  -260    /* UA,A */+   190   -60  -140   -60   190    /* UA,C */+  -260  -590  -260  -520  -260    /* UA,G */+   230   -60   230   -60   -70    /* UA,U */+   970   140   970   220   570    /* NS,E */+   570    30   570    20   570    /* NS,A */+   970   140   970   140   340    /* NS,C */+   570   100   570   220   570    /* NS,G */+   830   140   830   140   -50    /* NS,U */++# mismatch_interior+     0     0     0     0     0    /* CG,E */+     0     0     0   -80     0    /* CG,A */+     0     0     0     0     0    /* CG,C */+     0  -100     0  -100     0    /* CG,G */+     0     0     0     0   -60    /* CG,U */+     0     0     0     0     0    /* GC,E */+     0     0     0   -80     0    /* GC,A */+     0     0     0     0     0    /* GC,C */+     0  -100     0  -100     0    /* GC,G */+     0     0     0     0   -60    /* GC,U */+    70    70    70    70    70    /* GU,E */+    70    70    70   -10    70    /* GU,A */+    70    70    70    70    70    /* GU,C */+    70   -30    70   -30    70    /* GU,G */+    70    70    70    70    10    /* GU,U */+    70    70    70    70    70    /* UG,E */+    70    70    70   -10    70    /* UG,A */+    70    70    70    70    70    /* UG,C */+    70   -30    70   -30    70    /* UG,G */+    70    70    70    70    10    /* UG,U */+    70    70    70    70    70    /* AU,E */+    70    70    70   -10    70    /* AU,A */+    70    70    70    70    70    /* AU,C */+    70   -30    70   -30    70    /* AU,G */+    70    70    70    70    10    /* AU,U */+    70    70    70    70    70    /* UA,E */+    70    70    70   -10    70    /* UA,A */+    70    70    70    70    70    /* UA,C */+    70   -30    70   -30    70    /* UA,G */+    70    70    70    70    10    /* UA,U */+    70    70    70    70    70    /* NS,E */+    70    70    70   -10    70    /* NS,A */+    70    70    70    70    70    /* NS,C */+    70   -30    70   -30    70    /* NS,G */+    70    70    70    70    10    /* NS,U */++# mismatch_interior_enthalpies+   280     0     0   280     0    /* CG,E */+     0     0     0  -340     0    /* CG,A */+     0     0     0     0     0    /* CG,C */+   280  -760     0   280     0    /* CG,G */+     0     0     0     0  -580    /* CG,U */+   280     0     0   280     0    /* GC,E */+     0     0     0  -340     0    /* GC,A */+     0     0     0     0     0    /* GC,C */+   280  -760     0   280     0    /* GC,G */+     0     0     0     0  -580    /* GC,U */+   790   500   500   790   500    /* GU,E */+   500   500   500   170   500    /* GU,A */+   500   500   500   500   500    /* GU,C */+   790  -260   500   790   500    /* GU,G */+   500   500   500   500   -80    /* GU,U */+   790   500   500   790   500    /* UG,E */+   500   500   500   170   500    /* UG,A */+   500   500   500   500   500    /* UG,C */+   790  -260   500   790   500    /* UG,G */+   500   500   500   500   -80    /* UG,U */+   790   500   500   790   500    /* AU,E */+   500   500   500   170   500    /* AU,A */+   500   500   500   500   500    /* AU,C */+   790  -260   500   790   500    /* AU,G */+   500   500   500   500   -80    /* AU,U */+   790   500   500   790   500    /* UA,E */+   500   500   500   170   500    /* UA,A */+   500   500   500   500   500    /* UA,C */+   790  -260   500   790   500    /* UA,G */+   500   500   500   500   -80    /* UA,U */+   790   500   500   790   500    /* NS,E */+   500   500   500   170   500    /* NS,A */+   500   500   500   500   500    /* NS,C */+   790  -260   500   790   500    /* NS,G */+   500   500   500   500   -80    /* NS,U */++# mismatch_interior_1n+     0     0     0     0     0    /* CG,E */+     0     0     0     0     0    /* CG,A */+     0     0     0     0     0    /* CG,C */+     0     0     0     0     0    /* CG,G */+     0     0     0     0     0    /* CG,U */+     0     0     0     0     0    /* GC,E */+     0     0     0     0     0    /* GC,A */+     0     0     0     0     0    /* GC,C */+     0     0     0     0     0    /* GC,G */+     0     0     0     0     0    /* GC,U */+    70    70    70    70    70    /* GU,E */+    70    70    70    70    70    /* GU,A */+    70    70    70    70    70    /* GU,C */+    70    70    70    70    70    /* GU,G */+    70    70    70    70    70    /* GU,U */+    70    70    70    70    70    /* UG,E */+    70    70    70    70    70    /* UG,A */+    70    70    70    70    70    /* UG,C */+    70    70    70    70    70    /* UG,G */+    70    70    70    70    70    /* UG,U */+    70    70    70    70    70    /* AU,E */+    70    70    70    70    70    /* AU,A */+    70    70    70    70    70    /* AU,C */+    70    70    70    70    70    /* AU,G */+    70    70    70    70    70    /* AU,U */+    70    70    70    70    70    /* UA,E */+    70    70    70    70    70    /* UA,A */+    70    70    70    70    70    /* UA,C */+    70    70    70    70    70    /* UA,G */+    70    70    70    70    70    /* UA,U */+    70    70    70    70    70    /* NS,E */+    70    70    70    70    70    /* NS,A */+    70    70    70    70    70    /* NS,C */+    70    70    70    70    70    /* NS,G */+    70    70    70    70    70    /* NS,U */++# mismatch_interior_1n_enthalpies+     0     0     0     0     0    /* CG,E */+     0     0     0     0     0    /* CG,A */+     0     0     0     0     0    /* CG,C */+     0     0     0     0     0    /* CG,G */+     0     0     0     0     0    /* CG,U */+     0     0     0     0     0    /* GC,E */+     0     0     0     0     0    /* GC,A */+     0     0     0     0     0    /* GC,C */+     0     0     0     0     0    /* GC,G */+     0     0     0     0     0    /* GC,U */+   500   500   500   500   500    /* GU,E */+   500   500   500   500   500    /* GU,A */+   500   500   500   500   500    /* GU,C */+   500   500   500   500   500    /* GU,G */+   500   500   500   500   500    /* GU,U */+   500   500   500   500   500    /* UG,E */+   500   500   500   500   500    /* UG,A */+   500   500   500   500   500    /* UG,C */+   500   500   500   500   500    /* UG,G */+   500   500   500   500   500    /* UG,U */+   500   500   500   500   500    /* AU,E */+   500   500   500   500   500    /* AU,A */+   500   500   500   500   500    /* AU,C */+   500   500   500   500   500    /* AU,G */+   500   500   500   500   500    /* AU,U */+   500   500   500   500   500    /* UA,E */+   500   500   500   500   500    /* UA,A */+   500   500   500   500   500    /* UA,C */+   500   500   500   500   500    /* UA,G */+   500   500   500   500   500    /* UA,U */+   500   500   500   500   500    /* NS,E */+   500   500   500   500   500    /* NS,A */+   500   500   500   500   500    /* NS,C */+   500   500   500   500   500    /* NS,G */+   500   500   500   500   500    /* NS,U */++# mismatch_interior_23+     0     0     0     0     0    /* CG,E */+     0     0     0   -50     0    /* CG,A */+     0     0     0     0     0    /* CG,C */+     0  -110     0   -70     0    /* CG,G */+     0     0     0     0   -30    /* CG,U */+     0     0     0     0     0    /* GC,E */+     0     0     0     0     0    /* GC,A */+     0     0     0     0     0    /* GC,C */+     0  -120     0   -70     0    /* GC,G */+     0     0     0     0   -30    /* GC,U */+    70    70    70    70    70    /* GU,E */+    70    70    70    70    70    /* GU,A */+    70    70    70    70    70    /* GU,C */+    70   -40    70     0    70    /* GU,G */+    70    70    70    70    40    /* GU,U */+    70    70    70    70    70    /* UG,E */+    70    70    70    20    70    /* UG,A */+    70    70    70    70    70    /* UG,C */+    70   -40    70     0    70    /* UG,G */+    70    70    70    70    40    /* UG,U */+    70    70    70    70    70    /* AU,E */+    70    70    70    70    70    /* AU,A */+    70    70    70    70    70    /* AU,C */+    70   -40    70     0    70    /* AU,G */+    70    70    70    70    40    /* AU,U */+    70    70    70    70    70    /* UA,E */+    70    70    70    20    70    /* UA,A */+    70    70    70    70    70    /* UA,C */+    70   -40    70     0    70    /* UA,G */+    70    70    70    70    40    /* UA,U */+    70    70    70    70    70    /* NS,E */+    70    70    70    70    70    /* NS,A */+    70    70    70    70    70    /* NS,C */+    70   -40    70     0    70    /* NS,G */+    70    70    70    70    40    /* NS,U */++# mismatch_interior_23_enthalpies+     0     0     0     0     0    /* CG,E */+     0     0     0  -570     0    /* CG,A */+     0     0     0     0     0    /* CG,C */+     0  -860     0  -900     0    /* CG,G */+     0     0     0     0  -640    /* CG,U */+     0     0     0     0     0    /* GC,E */+     0     0     0     0     0    /* GC,A */+     0     0     0     0     0    /* GC,C */+     0 -1090     0  -900     0    /* GC,G */+     0     0     0     0  -640    /* GC,U */+   500   500   500   500   500    /* GU,E */+   500   500   500   500   500    /* GU,A */+   500   500   500   500   500    /* GU,C */+   500  -580   500  -400   500    /* GU,G */+   500   500   500   500  -140    /* GU,U */+   500   500   500   500   500    /* UG,E */+   500   500   500   -60   500    /* UG,A */+   500   500   500   500   500    /* UG,C */+   500  -360   500  -400   500    /* UG,G */+   500   500   500   500  -140    /* UG,U */+   500   500   500   500   500    /* AU,E */+   500   500   500   500   500    /* AU,A */+   500   500   500   500   500    /* AU,C */+   500  -580   500  -400   500    /* AU,G */+   500   500   500   500  -140    /* AU,U */+   500   500   500   500   500    /* UA,E */+   500   500   500   -60   500    /* UA,A */+   500   500   500   500   500    /* UA,C */+   500  -360   500  -400   500    /* UA,G */+   500   500   500   500  -140    /* UA,U */+   500   500   500   500   500    /* NS,E */+   500   500   500   500   500    /* NS,A */+   500   500   500   500   500    /* NS,C */+   500  -360   500  -400   500    /* NS,G */+   500   500   500   500  -140    /* NS,U */++# mismatch_multi+   -80  -100  -110  -100   -80    /* CG,E */+  -140  -150  -150  -140  -150    /* CG,A */+   -80  -100  -110  -100   -80    /* CG,C */+  -140  -140  -150  -160  -150    /* CG,G */+  -100  -100  -140  -100  -120    /* CG,U */+   -50  -110   -70  -110   -50    /* GC,E */+  -110  -110  -150  -130  -150    /* GC,A */+   -50  -110   -70  -110   -50    /* GC,C */+  -140  -160  -150  -140  -150    /* GC,G */+   -70  -110  -100  -110   -70    /* GC,U */+   -30   -30   -70   -60   -60    /* GU,E */+   -30   -30  -100   -80  -100    /* GU,A */+   -60   -60   -70   -60   -70    /* GU,C */+   -60   -60  -100   -80  -100    /* GU,G */+   -60   -60   -80   -60   -60    /* GU,U */+   -50   -50   -60   -70   -50    /* UG,E */+   -80  -100   -80  -110   -80    /* UG,A */+   -50   -70   -60   -70   -50    /* UG,C */+   -50   -50   -80   -80   -80    /* UG,G */+   -50   -70   -60   -70   -50    /* UG,U */+   -60   -60   -70   -60   -70    /* AU,E */+   -80   -80  -100   -80  -100    /* AU,A */+   -60   -60   -70   -60   -70    /* AU,C */+   -80   -80  -100   -80  -100    /* AU,G */+   -60   -60   -80   -60   -80    /* AU,U */+   -50   -70   -60   -70   -50    /* UA,E */+   -80  -100   -80  -110   -80    /* UA,A */+   -50   -70   -60   -70   -50    /* UA,C */+   -80  -110   -80  -120   -80    /* UA,G */+   -50   -70   -60   -70   -50    /* UA,U */+   -30   -30   -60   -60   -50    /* NS,E */+   -30   -30   -80   -80   -80    /* NS,A */+   -50   -60   -60   -60   -50    /* NS,C */+   -50   -50   -80   -80   -80    /* NS,G */+   -50   -60   -60   -60   -50    /* NS,U */++# mismatch_multi_enthalpies+  -270  -570  -340  -560  -270    /* CG,E */+  -560  -910  -560  -560  -560    /* CG,A */+  -270  -570  -340  -570  -270    /* CG,C */+  -560  -820  -560  -920  -560    /* CG,G */+  -530  -570  -530  -570  -860    /* CG,U */+    50  -520    50  -560  -400    /* GC,E */+  -400  -520  -400  -560  -400    /* GC,A */+    50  -720    50  -720  -420    /* GC,C */+  -400  -710  -400  -620  -400    /* GC,G */+   -30  -720   -30  -720  -500    /* GC,U */+   600   -60   600  -230   200    /* GU,E */+   200  -340   200  -350   200    /* GU,A */+   600  -230   600  -230   -30    /* GU,C */+   200   -60   200  -350   200    /* GU,G */+   460  -230   460  -230   160    /* GU,U */+   310   310  -140  -150   140    /* UG,E */+  -480  -480  -630  -890  -630    /* UG,A */+  -180  -430  -510  -430  -180    /* UG,C */+   310   310  -630  -150  -630    /* UG,G */+   140  -430  -140  -430   140    /* UG,U */+   600  -230   600  -230   200    /* AU,E */+   200  -390   200  -350   200    /* AU,A */+   600  -230   600  -230   -30    /* AU,C */+   200  -310   200  -350   200    /* AU,G */+   460  -230   460  -230  -170    /* AU,U */+   140  -380  -140  -430   140    /* UA,E */+  -400  -400  -630  -890  -630    /* UA,A */+  -180  -430  -510  -430  -180    /* UA,C */+  -380  -380  -630  -890  -630    /* UA,G */+   140  -430  -140  -430   140    /* UA,U */+   600   310   600  -150   200    /* NS,E */+   200  -340   200  -350   200    /* NS,A */+   600  -230   600  -230   -30    /* NS,C */+   310   310   200  -150   200    /* NS,G */+   460  -230   460  -230   160    /* NS,U */++# mismatch_exterior+   -80  -100  -110  -100   -80    /* CG,E */+  -140  -150  -150  -140  -150    /* CG,A */+   -80  -100  -110  -100   -80    /* CG,C */+  -140  -140  -150  -160  -150    /* CG,G */+  -100  -100  -140  -100  -120    /* CG,U */+   -50  -110   -70  -110   -50    /* GC,E */+  -110  -110  -150  -130  -150    /* GC,A */+   -50  -110   -70  -110   -50    /* GC,C */+  -140  -160  -150  -140  -150    /* GC,G */+   -70  -110  -100  -110   -70    /* GC,U */+   -30   -30   -70   -60   -60    /* GU,E */+   -30   -30  -100   -80  -100    /* GU,A */+   -60   -60   -70   -60   -70    /* GU,C */+   -60   -60  -100   -80  -100    /* GU,G */+   -60   -60   -80   -60   -60    /* GU,U */+   -50   -50   -60   -70   -50    /* UG,E */+   -80  -100   -80  -110   -80    /* UG,A */+   -50   -70   -60   -70   -50    /* UG,C */+   -50   -50   -80   -80   -80    /* UG,G */+   -50   -70   -60   -70   -50    /* UG,U */+   -60   -60   -70   -60   -70    /* AU,E */+   -80   -80  -100   -80  -100    /* AU,A */+   -60   -60   -70   -60   -70    /* AU,C */+   -80   -80  -100   -80  -100    /* AU,G */+   -60   -60   -80   -60   -80    /* AU,U */+   -50   -70   -60   -70   -50    /* UA,E */+   -80  -100   -80  -110   -80    /* UA,A */+   -50   -70   -60   -70   -50    /* UA,C */+   -80  -110   -80  -120   -80    /* UA,G */+   -50   -70   -60   -70   -50    /* UA,U */+   -30   -30   -60   -60   -50    /* NS,E */+   -30   -30   -80   -80   -80    /* NS,A */+   -50   -60   -60   -60   -50    /* NS,C */+   -50   -50   -80   -80   -80    /* NS,G */+   -50   -60   -60   -60   -50    /* NS,U */++# mismatch_exterior_enthalpies+  -270  -570  -340  -560  -270    /* CG,E */+  -560  -910  -560  -560  -560    /* CG,A */+  -270  -570  -340  -570  -270    /* CG,C */+  -560  -820  -560  -920  -560    /* CG,G */+  -530  -570  -530  -570  -860    /* CG,U */+    50  -520    50  -560  -400    /* GC,E */+  -400  -520  -400  -560  -400    /* GC,A */+    50  -720    50  -720  -420    /* GC,C */+  -400  -710  -400  -620  -400    /* GC,G */+   -30  -720   -30  -720  -500    /* GC,U */+   600   -60   600  -230   200    /* GU,E */+   200  -340   200  -350   200    /* GU,A */+   600  -230   600  -230   -30    /* GU,C */+   200   -60   200  -350   200    /* GU,G */+   460  -230   460  -230   160    /* GU,U */+   310   310  -140  -150   140    /* UG,E */+  -480  -480  -630  -890  -630    /* UG,A */+  -180  -430  -510  -430  -180    /* UG,C */+   310   310  -630  -150  -630    /* UG,G */+   140  -430  -140  -430   140    /* UG,U */+   600  -230   600  -230   200    /* AU,E */+   200  -390   200  -350   200    /* AU,A */+   600  -230   600  -230   -30    /* AU,C */+   200  -310   200  -350   200    /* AU,G */+   460  -230   460  -230  -170    /* AU,U */+   140  -380  -140  -430   140    /* UA,E */+  -400  -400  -630  -890  -630    /* UA,A */+  -180  -430  -510  -430  -180    /* UA,C */+  -380  -380  -630  -890  -630    /* UA,G */+   140  -430  -140  -430   140    /* UA,U */+   600   310   600  -150   200    /* NS,E */+   200  -340   200  -350   200    /* NS,A */+   600  -230   600  -230   -30    /* NS,C */+   310   310   200  -150   200    /* NS,G */+   460  -230   460  -230   160    /* NS,U */++# dangle5+     0   -20   -30     0     0    /* CG */+   -10   -50   -30   -20   -10    /* GC */+   -10   -30   -10   -20   -20    /* GU */+   -20   -30   -30   -40   -20    /* UG */+   -10   -30   -10   -20   -20    /* AU */+   -20   -30   -30   -40   -20    /* UA */+     0   -20   -10     0     0    /* NS */++# dangle5_enthalpies+    70  -160    70  -460   -40    /* CG */+   330  -240   330    80  -140    /* GC */+   690   -50   690    60    60    /* GU */+   310   160   220    70   310    /* UG */+   690   -50   690    60    60    /* AU */+   310   160   220    70   310    /* UA */+   690   160   690    80   310    /* NS */++# dangle3+   -80  -170   -80  -170  -120    /* CG */+   -40  -110   -40  -130   -60    /* GC */+   -50   -80   -50   -80   -60    /* GU */+   -10   -70   -10   -70   -10    /* UG */+   -50   -80   -50   -80   -60    /* AU */+   -10   -70   -10   -70   -10    /* UA */+   -10   -70   -10   -70   -10    /* NS */++# dangle3_enthalpies+  -410  -900  -410  -860  -750    /* CG */+  -280  -740  -280  -640  -360    /* GC */+   -90  -490   -90  -550  -230    /* GU */+   -70  -570   -70  -580  -220    /* UG */+   -90  -490   -90  -550  -230    /* AU */+   -70  -570   -70  -580  -220    /* UA */+   -70  -490   -70  -550  -220    /* NS */++# int11+    90    90    50    50    50    /* CG,CG,E */+    90    90    50    50    50    /* CG,CG,A */+    50    50    50    50    50    /* CG,CG,C */+    50    50    50  -140    50    /* CG,CG,G */+    50    50    50    50    40    /* CG,CG,U */+    90    90    50    50    60    /* CG,GC,E */+    90    90   -40    50    50    /* CG,GC,A */+    60    30    50    50    60    /* CG,GC,C */+    50   -10    50  -220    50    /* CG,GC,G */+    50    50     0    50   -10    /* CG,GC,U */+   120   120   120   120   120    /* CG,GU,E */+   120    60    50   120   120    /* CG,GU,A */+   120   120   120   120   120    /* CG,GU,C */+   120   -20   120  -140   120    /* CG,GU,G */+   120   120   100   120   110    /* CG,GU,U */+   220   220   170   120   120    /* CG,UG,E */+   220   220   130   120   120    /* CG,UG,A */+   170   120   170   120   120    /* CG,UG,C */+   120   120   120  -140   120    /* CG,UG,G */+   120   120   120   120   110    /* CG,UG,U */+   120   120   120   120   120    /* CG,AU,E */+   120   120   120   120   120    /* CG,AU,A */+   120   120   120   120   120    /* CG,AU,C */+   120   120   120  -140   120    /* CG,AU,G */+   120   120   120   120    80    /* CG,AU,U */+   120   120   120   120   120    /* CG,UA,E */+   120   120   120   120   120    /* CG,UA,A */+   120   120   120   120   120    /* CG,UA,C */+   120   120   120  -140   120    /* CG,UA,G */+   120   120   120   120   120    /* CG,UA,U */+   220   220   170   120   120    /* CG,NS,E */+   220   220   130   120   120    /* CG,NS,A */+   170   120   170   120   120    /* CG,NS,C */+   120   120   120  -140   120    /* CG,NS,G */+   120   120   120   120   120    /* CG,NS,U */+    90    90    60    50    50    /* GC,CG,E */+    90    90    30   -10    50    /* GC,CG,A */+    50   -40    50    50     0    /* GC,CG,C */+    50    50    50  -220    50    /* GC,CG,G */+    60    50    60    50   -10    /* GC,CG,U */+    80    80    50    50    50    /* GC,GC,E */+    80    80    50    50    50    /* GC,GC,A */+    50    50    50    50    50    /* GC,GC,C */+    50    50    50  -230    50    /* GC,GC,G */+    50    50    50    50   -60    /* GC,GC,U */+   190   190   120   150   150    /* GC,GU,E */+   190   190   120   150   120    /* GC,GU,A */+   120   120   120   120   120    /* GC,GU,C */+   120   120   120  -140   120    /* GC,GU,G */+   150   120   120   120   150    /* GC,GU,U */+   160   160   120   120   120    /* GC,UG,E */+   160   160   120   100   120    /* GC,UG,A */+   120   120   120   120   120    /* GC,UG,C */+   120   120   120  -140   120    /* GC,UG,G */+   120   120   120   120    70    /* GC,UG,U */+   120   120   120   120   120    /* GC,AU,E */+   120   120   120   120   120    /* GC,AU,A */+   120   120   120   120   120    /* GC,AU,C */+   120   120   120  -140   120    /* GC,AU,G */+   120   120   120   120    80    /* GC,AU,U */+   120   120   120   120   120    /* GC,UA,E */+   120   120   120   120   120    /* GC,UA,A */+   120   120   120   120   120    /* GC,UA,C */+   120   120   120  -140   120    /* GC,UA,G */+   120   120   120   120   120    /* GC,UA,U */+   190   190   120   150   150    /* GC,NS,E */+   190   190   120   150   120    /* GC,NS,A */+   120   120   120   120   120    /* GC,NS,C */+   120   120   120  -140   120    /* GC,NS,G */+   150   120   120   120   150    /* GC,NS,U */+   120   120   120   120   120    /* GU,CG,E */+   120    60   120   -20   120    /* GU,CG,A */+   120    50   120   120   100    /* GU,CG,C */+   120   120   120  -140   120    /* GU,CG,G */+   120   120   120   120   110    /* GU,CG,U */+   190   190   120   120   150    /* GU,GC,E */+   190   190   120   120   120    /* GU,GC,A */+   120   120   120   120   120    /* GU,GC,C */+   150   150   120  -140   120    /* GU,GC,G */+   150   120   120   120   150    /* GU,GC,U */+   190   190   190   190   190    /* GU,GU,E */+   190   190   190   190   190    /* GU,GU,A */+   190   190   190   190   190    /* GU,GU,C */+   190   190   190   -70   190    /* GU,GU,G */+   190   190   190   190   120    /* GU,GU,U */+   190   190   190   190   190    /* GU,UG,E */+   190   190   190   190   190    /* GU,UG,A */+   190   190   190   190   190    /* GU,UG,C */+   190   190   190   -70   190    /* GU,UG,G */+   190   190   190   190   160    /* GU,UG,U */+   190   190   190   190   190    /* GU,AU,E */+   190   190   190   190   190    /* GU,AU,A */+   190   190   190   190   190    /* GU,AU,C */+   190   190   190   -70   190    /* GU,AU,G */+   190   190   190   190   120    /* GU,AU,U */+   190   190   190   190   190    /* GU,UA,E */+   190   190   190   190   190    /* GU,UA,A */+   190   190   190   190   190    /* GU,UA,C */+   190   190   190   -70   190    /* GU,UA,G */+   190   190   190   190   160    /* GU,UA,U */+   190   190   190   190   190    /* GU,NS,E */+   190   190   190   190   190    /* GU,NS,A */+   190   190   190   190   190    /* GU,NS,C */+   190   190   190   -70   190    /* GU,NS,G */+   190   190   190   190   160    /* GU,NS,U */+   220   220   170   120   120    /* UG,CG,E */+   220   220   120   120   120    /* UG,CG,A */+   170   130   170   120   120    /* UG,CG,C */+   120   120   120  -140   120    /* UG,CG,G */+   120   120   120   120   110    /* UG,CG,U */+   160   160   120   120   120    /* UG,GC,E */+   160   160   120   120   120    /* UG,GC,A */+   120   120   120   120   120    /* UG,GC,C */+   120   100   120  -140   120    /* UG,GC,G */+   120   120   120   120    70    /* UG,GC,U */+   190   190   190   190   190    /* UG,GU,E */+   190   190   190   190   190    /* UG,GU,A */+   190   190   190   190   190    /* UG,GU,C */+   190   190   190   -70   190    /* UG,GU,G */+   190   190   190   190   160    /* UG,GU,U */+   190   190   190   190   190    /* UG,UG,E */+   190   190   190   190   190    /* UG,UG,A */+   190   190   190   190   190    /* UG,UG,C */+   190   190   190   -70   190    /* UG,UG,G */+   190   190   190   190   190    /* UG,UG,U */+   190   190   190   190   190    /* UG,AU,E */+   190   190   190   190   190    /* UG,AU,A */+   190   190   190   190   190    /* UG,AU,C */+   190   190   190   -70   190    /* UG,AU,G */+   190   190   190   190   160    /* UG,AU,U */+   190   190   190   190   190    /* UG,UA,E */+   190   190   190   190   190    /* UG,UA,A */+   190   190   190   190   190    /* UG,UA,C */+   190   190   190   -70   190    /* UG,UA,G */+   190   190   190   190   190    /* UG,UA,U */+   220   220   190   190   190    /* UG,NS,E */+   220   220   190   190   190    /* UG,NS,A */+   190   190   190   190   190    /* UG,NS,C */+   190   190   190   -70   190    /* UG,NS,G */+   190   190   190   190   190    /* UG,NS,U */+   120   120   120   120   120    /* AU,CG,E */+   120   120   120   120   120    /* AU,CG,A */+   120   120   120   120   120    /* AU,CG,C */+   120   120   120  -140   120    /* AU,CG,G */+   120   120   120   120    80    /* AU,CG,U */+   120   120   120   120   120    /* AU,GC,E */+   120   120   120   120   120    /* AU,GC,A */+   120   120   120   120   120    /* AU,GC,C */+   120   120   120  -140   120    /* AU,GC,G */+   120   120   120   120    80    /* AU,GC,U */+   190   190   190   190   190    /* AU,GU,E */+   190   190   190   190   190    /* AU,GU,A */+   190   190   190   190   190    /* AU,GU,C */+   190   190   190   -70   190    /* AU,GU,G */+   190   190   190   190   120    /* AU,GU,U */+   190   190   190   190   190    /* AU,UG,E */+   190   190   190   190   190    /* AU,UG,A */+   190   190   190   190   190    /* AU,UG,C */+   190   190   190   -70   190    /* AU,UG,G */+   190   190   190   190   160    /* AU,UG,U */+   190   190   190   190   190    /* AU,AU,E */+   190   190   190   190   190    /* AU,AU,A */+   190   190   190   190   190    /* AU,AU,C */+   190   190   190   -70   190    /* AU,AU,G */+   190   190   190   190   120    /* AU,AU,U */+   190   190   190   190   190    /* AU,UA,E */+   190   190   190   190   190    /* AU,UA,A */+   190   190   190   190   190    /* AU,UA,C */+   190   190   190   -70   190    /* AU,UA,G */+   190   190   190   190   150    /* AU,UA,U */+   190   190   190   190   190    /* AU,NS,E */+   190   190   190   190   190    /* AU,NS,A */+   190   190   190   190   190    /* AU,NS,C */+   190   190   190   -70   190    /* AU,NS,G */+   190   190   190   190   160    /* AU,NS,U */+   120   120   120   120   120    /* UA,CG,E */+   120   120   120   120   120    /* UA,CG,A */+   120   120   120   120   120    /* UA,CG,C */+   120   120   120  -140   120    /* UA,CG,G */+   120   120   120   120   120    /* UA,CG,U */+   120   120   120   120   120    /* UA,GC,E */+   120   120   120   120   120    /* UA,GC,A */+   120   120   120   120   120    /* UA,GC,C */+   120   120   120  -140   120    /* UA,GC,G */+   120   120   120   120   120    /* UA,GC,U */+   190   190   190   190   190    /* UA,GU,E */+   190   190   190   190   190    /* UA,GU,A */+   190   190   190   190   190    /* UA,GU,C */+   190   190   190   -70   190    /* UA,GU,G */+   190   190   190   190   160    /* UA,GU,U */+   190   190   190   190   190    /* UA,UG,E */+   190   190   190   190   190    /* UA,UG,A */+   190   190   190   190   190    /* UA,UG,C */+   190   190   190   -70   190    /* UA,UG,G */+   190   190   190   190   190    /* UA,UG,U */+   190   190   190   190   190    /* UA,AU,E */+   190   190   190   190   190    /* UA,AU,A */+   190   190   190   190   190    /* UA,AU,C */+   190   190   190   -70   190    /* UA,AU,G */+   190   190   190   190   150    /* UA,AU,U */+   190   190   190   190   190    /* UA,UA,E */+   190   190   190   190   190    /* UA,UA,A */+   190   190   190   190   190    /* UA,UA,C */+   190   190   190   -70   190    /* UA,UA,G */+   190   190   190   190   170    /* UA,UA,U */+   190   190   190   190   190    /* UA,NS,E */+   190   190   190   190   190    /* UA,NS,A */+   190   190   190   190   190    /* UA,NS,C */+   190   190   190   -70   190    /* UA,NS,G */+   190   190   190   190   190    /* UA,NS,U */+   220   220   170   120   120    /* NS,CG,E */+   220   220   120   120   120    /* NS,CG,A */+   170   130   170   120   120    /* NS,CG,C */+   120   120   120  -140   120    /* NS,CG,G */+   120   120   120   120   120    /* NS,CG,U */+   190   190   120   120   150    /* NS,GC,E */+   190   190   120   120   120    /* NS,GC,A */+   120   120   120   120   120    /* NS,GC,C */+   150   150   120  -140   120    /* NS,GC,G */+   150   120   120   120   150    /* NS,GC,U */+   190   190   190   190   190    /* NS,GU,E */+   190   190   190   190   190    /* NS,GU,A */+   190   190   190   190   190    /* NS,GU,C */+   190   190   190   -70   190    /* NS,GU,G */+   190   190   190   190   160    /* NS,GU,U */+   220   220   190   190   190    /* NS,UG,E */+   220   220   190   190   190    /* NS,UG,A */+   190   190   190   190   190    /* NS,UG,C */+   190   190   190   -70   190    /* NS,UG,G */+   190   190   190   190   190    /* NS,UG,U */+   190   190   190   190   190    /* NS,AU,E */+   190   190   190   190   190    /* NS,AU,A */+   190   190   190   190   190    /* NS,AU,C */+   190   190   190   -70   190    /* NS,AU,G */+   190   190   190   190   160    /* NS,AU,U */+   190   190   190   190   190    /* NS,UA,E */+   190   190   190   190   190    /* NS,UA,A */+   190   190   190   190   190    /* NS,UA,C */+   190   190   190   -70   190    /* NS,UA,G */+   190   190   190   190   190    /* NS,UA,U */+   220   220   190   190   190    /* NS,NS,E */+   220   220   190   190   190    /* NS,NS,A */+   190   190   190   190   190    /* NS,NS,C */+   190   190   190   -70   190    /* NS,NS,G */+   190   190   190   190   190    /* NS,NS,U */++# int11_enthalpies+ -1050 -1050 -1050 -1050 -1050    /* CG,CG,E */+ -1050 -1050 -1050 -1050 -1050    /* CG,CG,A */+ -1050 -1050 -1050 -1050 -1050    /* CG,CG,C */+ -1050 -1050 -1050 -1840 -1050    /* CG,CG,G */+ -1050 -1050 -1050 -1050 -1050    /* CG,CG,U */+ -1050 -1050 -1050 -1050 -1050    /* CG,GC,E */+ -1050 -1050 -1050 -1050 -1050    /* CG,GC,A */+ -1050 -1050 -1050 -1050 -1050    /* CG,GC,C */+ -1050 -1050 -1050 -1840 -1050    /* CG,GC,G */+ -1050 -1050 -1050 -1050 -1390    /* CG,GC,U */+  -550  -550  -550  -550  -550    /* CG,GU,E */+  -550  -550  -550  -550  -550    /* CG,GU,A */+  -550  -550  -550  -550  -550    /* CG,GU,C */+  -550  -550  -550 -1340  -550    /* CG,GU,G */+  -550  -550  -550  -550  -890    /* CG,GU,U */+  -550  -550  -550  -550  -550    /* CG,UG,E */+  -550  -550  -550  -550  -550    /* CG,UG,A */+  -550  -550  -550  -550  -550    /* CG,UG,C */+  -550  -550  -550 -1340  -550    /* CG,UG,G */+  -550  -550  -550  -550  -550    /* CG,UG,U */+  -550  -550  -550  -550  -550    /* CG,AU,E */+  -550  -550  -550  -550  -550    /* CG,AU,A */+  -550  -550  -550  -550  -550    /* CG,AU,C */+  -550  -550  -550 -1340  -550    /* CG,AU,G */+  -550  -550  -550  -550  -890    /* CG,AU,U */+  -550  -550  -550  -550  -550    /* CG,UA,E */+  -550  -550  -550  -550  -550    /* CG,UA,A */+  -550  -550  -550  -550  -550    /* CG,UA,C */+  -550  -550  -550 -1340  -550    /* CG,UA,G */+  -550  -550  -550  -550  -550    /* CG,UA,U */+  -550  -550  -550  -550  -550    /* CG,NS,E */+  -550  -550  -550  -550  -550    /* CG,NS,A */+  -550  -550  -550  -550  -550    /* CG,NS,C */+  -550  -550  -550 -1340  -550    /* CG,NS,G */+  -550  -550  -550  -550  -550    /* CG,NS,U */+ -1050 -1050 -1050 -1050 -1050    /* GC,CG,E */+ -1050 -1050 -1050 -1050 -1050    /* GC,CG,A */+ -1050 -1050 -1050 -1050 -1050    /* GC,CG,C */+ -1050 -1050 -1050 -1840 -1050    /* GC,CG,G */+ -1050 -1050 -1050 -1050 -1390    /* GC,CG,U */+ -1050 -1050 -1050 -1050 -1050    /* GC,GC,E */+ -1050 -1050 -1050 -1050 -1050    /* GC,GC,A */+ -1050 -1050 -1050 -1050 -1050    /* GC,GC,C */+ -1050 -1050 -1050 -1840 -1050    /* GC,GC,G */+ -1050 -1050 -1050 -1050 -1730    /* GC,GC,U */+  -550  -550  -550  -550  -550    /* GC,GU,E */+  -550  -550  -550  -550  -550    /* GC,GU,A */+  -550  -550  -550  -550  -550    /* GC,GU,C */+  -550  -550  -550 -1340  -550    /* GC,GU,G */+  -550  -550  -550  -550 -1230    /* GC,GU,U */+  -550  -550  -550  -550  -550    /* GC,UG,E */+  -550  -550  -550  -550  -550    /* GC,UG,A */+  -550  -550  -550  -550  -550    /* GC,UG,C */+  -550  -550  -550 -1340  -550    /* GC,UG,G */+  -550  -550  -550  -550  -890    /* GC,UG,U */+  -550  -550  -550  -550  -550    /* GC,AU,E */+  -550  -550  -550  -550  -550    /* GC,AU,A */+  -550  -550  -550  -550  -550    /* GC,AU,C */+  -550  -550  -550 -1340  -550    /* GC,AU,G */+  -550  -550  -550  -550 -1230    /* GC,AU,U */+  -550  -550  -550  -550  -550    /* GC,UA,E */+  -550  -550  -550  -550  -550    /* GC,UA,A */+  -550  -550  -550  -550  -550    /* GC,UA,C */+  -550  -550  -550 -1340  -550    /* GC,UA,G */+  -550  -550  -550  -550  -890    /* GC,UA,U */+  -550  -550  -550  -550  -550    /* GC,NS,E */+  -550  -550  -550  -550  -550    /* GC,NS,A */+  -550  -550  -550  -550  -550    /* GC,NS,C */+  -550  -550  -550 -1340  -550    /* GC,NS,G */+  -550  -550  -550  -550  -890    /* GC,NS,U */+  -550  -550  -550  -550  -550    /* GU,CG,E */+  -550  -550  -550  -550  -550    /* GU,CG,A */+  -550  -550  -550  -550  -550    /* GU,CG,C */+  -550  -550  -550 -1340  -550    /* GU,CG,G */+  -550  -550  -550  -550  -890    /* GU,CG,U */+  -550  -550  -550  -550  -550    /* GU,GC,E */+  -550  -550  -550  -550  -550    /* GU,GC,A */+  -550  -550  -550  -550  -550    /* GU,GC,C */+  -550  -550  -550 -1340  -550    /* GU,GC,G */+  -550  -550  -550  -550 -1230    /* GU,GC,U */+   -50   -50   -50   -50   -50    /* GU,GU,E */+   -50   -50   -50   -50   -50    /* GU,GU,A */+   -50   -50   -50   -50   -50    /* GU,GU,C */+   -50   -50   -50  -830   -50    /* GU,GU,G */+   -50   -50   -50   -50  -730    /* GU,GU,U */+   -50   -50   -50   -50   -50    /* GU,UG,E */+   -50   -50   -50   -50   -50    /* GU,UG,A */+   -50   -50   -50   -50   -50    /* GU,UG,C */+   -50   -50   -50  -830   -50    /* GU,UG,G */+   -50   -50   -50   -50  -390    /* GU,UG,U */+   -50   -50   -50   -50   -50    /* GU,AU,E */+   -50   -50   -50   -50   -50    /* GU,AU,A */+   -50   -50   -50   -50   -50    /* GU,AU,C */+   -50   -50   -50  -830   -50    /* GU,AU,G */+   -50   -50   -50   -50  -730    /* GU,AU,U */+   -50   -50   -50   -50   -50    /* GU,UA,E */+   -50   -50   -50   -50   -50    /* GU,UA,A */+   -50   -50   -50   -50   -50    /* GU,UA,C */+   -50   -50   -50  -830   -50    /* GU,UA,G */+   -50   -50   -50   -50  -390    /* GU,UA,U */+   -50   -50   -50   -50   -50    /* GU,NS,E */+   -50   -50   -50   -50   -50    /* GU,NS,A */+   -50   -50   -50   -50   -50    /* GU,NS,C */+   -50   -50   -50  -830   -50    /* GU,NS,G */+   -50   -50   -50   -50  -390    /* GU,NS,U */+  -550  -550  -550  -550  -550    /* UG,CG,E */+  -550  -550  -550  -550  -550    /* UG,CG,A */+  -550  -550  -550  -550  -550    /* UG,CG,C */+  -550  -550  -550 -1340  -550    /* UG,CG,G */+  -550  -550  -550  -550  -550    /* UG,CG,U */+  -550  -550  -550  -550  -550    /* UG,GC,E */+  -550  -550  -550  -550  -550    /* UG,GC,A */+  -550  -550  -550  -550  -550    /* UG,GC,C */+  -550  -550  -550 -1340  -550    /* UG,GC,G */+  -550  -550  -550  -550  -890    /* UG,GC,U */+   -50   -50   -50   -50   -50    /* UG,GU,E */+   -50   -50   -50   -50   -50    /* UG,GU,A */+   -50   -50   -50   -50   -50    /* UG,GU,C */+   -50   -50   -50  -830   -50    /* UG,GU,G */+   -50   -50   -50   -50  -390    /* UG,GU,U */+   -50   -50   -50   -50   -50    /* UG,UG,E */+   -50   -50   -50   -50   -50    /* UG,UG,A */+   -50   -50   -50   -50   -50    /* UG,UG,C */+   -50   -50   -50  -830   -50    /* UG,UG,G */+   -50   -50   -50   -50   -50    /* UG,UG,U */+   -50   -50   -50   -50   -50    /* UG,AU,E */+   -50   -50   -50   -50   -50    /* UG,AU,A */+   -50   -50   -50   -50   -50    /* UG,AU,C */+   -50   -50   -50  -830   -50    /* UG,AU,G */+   -50   -50   -50   -50  -390    /* UG,AU,U */+   -50   -50   -50   -50   -50    /* UG,UA,E */+   -50   -50   -50   -50   -50    /* UG,UA,A */+   -50   -50   -50   -50   -50    /* UG,UA,C */+   -50   -50   -50  -830   -50    /* UG,UA,G */+   -50   -50   -50   -50   -50    /* UG,UA,U */+   -50   -50   -50   -50   -50    /* UG,NS,E */+   -50   -50   -50   -50   -50    /* UG,NS,A */+   -50   -50   -50   -50   -50    /* UG,NS,C */+   -50   -50   -50  -830   -50    /* UG,NS,G */+   -50   -50   -50   -50   -50    /* UG,NS,U */+  -550  -550  -550  -550  -550    /* AU,CG,E */+  -550  -550  -550  -550  -550    /* AU,CG,A */+  -550  -550  -550  -550  -550    /* AU,CG,C */+  -550  -550  -550 -1340  -550    /* AU,CG,G */+  -550  -550  -550  -550  -890    /* AU,CG,U */+  -550  -550  -550  -550  -550    /* AU,GC,E */+  -550  -550  -550  -550  -550    /* AU,GC,A */+  -550  -550  -550  -550  -550    /* AU,GC,C */+  -550  -550  -550 -1340  -550    /* AU,GC,G */+  -550  -550  -550  -550 -1230    /* AU,GC,U */+   -50   -50   -50   -50   -50    /* AU,GU,E */+   -50   -50   -50   -50   -50    /* AU,GU,A */+   -50   -50   -50   -50   -50    /* AU,GU,C */+   -50   -50   -50  -830   -50    /* AU,GU,G */+   -50   -50   -50   -50  -730    /* AU,GU,U */+   -50   -50   -50   -50   -50    /* AU,UG,E */+   -50   -50   -50   -50   -50    /* AU,UG,A */+   -50   -50   -50   -50   -50    /* AU,UG,C */+   -50   -50   -50  -830   -50    /* AU,UG,G */+   -50   -50   -50   -50  -390    /* AU,UG,U */+   -50   -50   -50   -50   -50    /* AU,AU,E */+   -50   -50   -50   -50   -50    /* AU,AU,A */+   -50   -50   -50   -50   -50    /* AU,AU,C */+   -50   -50   -50  -830   -50    /* AU,AU,G */+   -50   -50   -50   -50  -730    /* AU,AU,U */+   -50   -50   -50   -50   -50    /* AU,UA,E */+   -50   -50   -50   -50   -50    /* AU,UA,A */+   -50   -50   -50   -50   -50    /* AU,UA,C */+   -50   -50   -50  -830   -50    /* AU,UA,G */+   -50   -50   -50   -50  -390    /* AU,UA,U */+   -50   -50   -50   -50   -50    /* AU,NS,E */+   -50   -50   -50   -50   -50    /* AU,NS,A */+   -50   -50   -50   -50   -50    /* AU,NS,C */+   -50   -50   -50  -830   -50    /* AU,NS,G */+   -50   -50   -50   -50  -390    /* AU,NS,U */+  -550  -550  -550  -550  -550    /* UA,CG,E */+  -550  -550  -550  -550  -550    /* UA,CG,A */+  -550  -550  -550  -550  -550    /* UA,CG,C */+  -550  -550  -550 -1340  -550    /* UA,CG,G */+  -550  -550  -550  -550  -550    /* UA,CG,U */+  -550  -550  -550  -550  -550    /* UA,GC,E */+  -550  -550  -550  -550  -550    /* UA,GC,A */+  -550  -550  -550  -550  -550    /* UA,GC,C */+  -550  -550  -550 -1340  -550    /* UA,GC,G */+  -550  -550  -550  -550  -890    /* UA,GC,U */+   -50   -50   -50   -50   -50    /* UA,GU,E */+   -50   -50   -50   -50   -50    /* UA,GU,A */+   -50   -50   -50   -50   -50    /* UA,GU,C */+   -50   -50   -50  -830   -50    /* UA,GU,G */+   -50   -50   -50   -50  -390    /* UA,GU,U */+   -50   -50   -50   -50   -50    /* UA,UG,E */+   -50   -50   -50   -50   -50    /* UA,UG,A */+   -50   -50   -50   -50   -50    /* UA,UG,C */+   -50   -50   -50  -830   -50    /* UA,UG,G */+   -50   -50   -50   -50   -50    /* UA,UG,U */+   -50   -50   -50   -50   -50    /* UA,AU,E */+   -50   -50   -50   -50   -50    /* UA,AU,A */+   -50   -50   -50   -50   -50    /* UA,AU,C */+   -50   -50   -50  -830   -50    /* UA,AU,G */+   -50   -50   -50   -50  -390    /* UA,AU,U */+   -50   -50   -50   -50   -50    /* UA,UA,E */+   -50   -50   -50   -50   -50    /* UA,UA,A */+   -50   -50   -50   -50   -50    /* UA,UA,C */+   -50   -50   -50  -830   -50    /* UA,UA,G */+   -50   -50   -50   -50   -50    /* UA,UA,U */+   -50   -50   -50   -50   -50    /* UA,NS,E */+   -50   -50   -50   -50   -50    /* UA,NS,A */+   -50   -50   -50   -50   -50    /* UA,NS,C */+   -50   -50   -50  -830   -50    /* UA,NS,G */+   -50   -50   -50   -50   -50    /* UA,NS,U */+  -550  -550  -550  -550  -550    /* NS,CG,E */+  -550  -550  -550  -550  -550    /* NS,CG,A */+  -550  -550  -550  -550  -550    /* NS,CG,C */+  -550  -550  -550 -1340  -550    /* NS,CG,G */+  -550  -550  -550  -550  -550    /* NS,CG,U */+  -550  -550  -550  -550  -550    /* NS,GC,E */+  -550  -550  -550  -550  -550    /* NS,GC,A */+  -550  -550  -550  -550  -550    /* NS,GC,C */+  -550  -550  -550 -1340  -550    /* NS,GC,G */+  -550  -550  -550  -550  -890    /* NS,GC,U */+   -50   -50   -50   -50   -50    /* NS,GU,E */+   -50   -50   -50   -50   -50    /* NS,GU,A */+   -50   -50   -50   -50   -50    /* NS,GU,C */+   -50   -50   -50  -830   -50    /* NS,GU,G */+   -50   -50   -50   -50  -390    /* NS,GU,U */+   -50   -50   -50   -50   -50    /* NS,UG,E */+   -50   -50   -50   -50   -50    /* NS,UG,A */+   -50   -50   -50   -50   -50    /* NS,UG,C */+   -50   -50   -50  -830   -50    /* NS,UG,G */+   -50   -50   -50   -50   -50    /* NS,UG,U */+   -50   -50   -50   -50   -50    /* NS,AU,E */+   -50   -50   -50   -50   -50    /* NS,AU,A */+   -50   -50   -50   -50   -50    /* NS,AU,C */+   -50   -50   -50  -830   -50    /* NS,AU,G */+   -50   -50   -50   -50  -390    /* NS,AU,U */+   -50   -50   -50   -50   -50    /* NS,UA,E */+   -50   -50   -50   -50   -50    /* NS,UA,A */+   -50   -50   -50   -50   -50    /* NS,UA,C */+   -50   -50   -50  -830   -50    /* NS,UA,G */+   -50   -50   -50   -50   -50    /* NS,UA,U */+   -50   -50   -50   -50   -50    /* NS,NS,E */+   -50   -50   -50   -50   -50    /* NS,NS,A */+   -50   -50   -50   -50   -50    /* NS,NS,C */+   -50   -50   -50  -830   -50    /* NS,NS,G */+   -50   -50   -50   -50   -50    /* NS,NS,U */++# int21+   230   230   230   230   230    /* CG,CG,E,E */+   230   230   230   230   230    /* CG,CG,E,A */+   230   230   230   230   230    /* CG,CG,E,C */+   230   230   230   230   230    /* CG,CG,E,G */+   230   230   230   230   230    /* CG,CG,E,U */+   230   230   230   110   230    /* CG,CG,A,E */+   230   230   230   110   230    /* CG,CG,A,A */+   230   230   230   110   230    /* CG,CG,A,C */+   110   110   110   110   110    /* CG,CG,A,G */+   230   230   230   110   230    /* CG,CG,A,U */+   230   230   230   230   230    /* CG,CG,C,E */+   230   230   230   230   230    /* CG,CG,C,A */+   230   230   230   230   230    /* CG,CG,C,C */+   230   230   230   230   230    /* CG,CG,C,G */+   230   230   230   230   230    /* CG,CG,C,U */+   230   110   230   110   230    /* CG,CG,G,E */+   110   110   110   110   110    /* CG,CG,G,A */+   230   110   230   110   230    /* CG,CG,G,C */+   110   110   110   110   110    /* CG,CG,G,G */+   230   110   230   110   230    /* CG,CG,G,U */+   230   230   230   230   150    /* CG,CG,U,E */+   230   230   230   230   150    /* CG,CG,U,A */+   230   230   230   230   150    /* CG,CG,U,C */+   230   230   230   230   150    /* CG,CG,U,G */+   150   150   150   150   150    /* CG,CG,U,U */+   250   250   250   230   230    /* CG,GC,E,E */+   250   250   230   230   230    /* CG,GC,E,A */+   250   230   250   230   230    /* CG,GC,E,C */+   230   230   230   230   230    /* CG,GC,E,G */+   250   250   230   230   230    /* CG,GC,E,U */+   250   250   230   110   230    /* CG,GC,A,E */+   250   250   230   110   230    /* CG,GC,A,A */+   230   230   170   110   230    /* CG,GC,A,C */+   110    80   110   110   110    /* CG,GC,A,G */+   230   230   230   110   230    /* CG,GC,A,U */+   250   250   250   230   230    /* CG,GC,C,E */+   230   230   230   230   230    /* CG,GC,C,A */+   250   230   250   230   230    /* CG,GC,C,C */+   230   230   230   230   230    /* CG,GC,C,G */+   250   250   230   230   230    /* CG,GC,C,U */+   230   170   230   110   230    /* CG,GC,G,E */+   230   170   230    80   230    /* CG,GC,G,A */+   230   110   230   110   230    /* CG,GC,G,C */+   120   120   110   110   110    /* CG,GC,G,G */+   230   110   230   110   230    /* CG,GC,G,U */+   230   230   230   230   150    /* CG,GC,U,E */+   230   230   230   230   150    /* CG,GC,U,A */+   230   230   220   230   150    /* CG,GC,U,C */+   230   230   230   230   150    /* CG,GC,U,G */+   170   150   170   150   140    /* CG,GC,U,U */+   300   300   300   300   300    /* CG,GU,E,E */+   300   300   300   300   300    /* CG,GU,E,A */+   300   300   300   300   300    /* CG,GU,E,C */+   300   300   300   300   300    /* CG,GU,E,G */+   300   300   300   300   300    /* CG,GU,E,U */+   300   300   300   190   300    /* CG,GU,A,E */+   300   300   300   190   300    /* CG,GU,A,A */+   300   300   300   190   300    /* CG,GU,A,C */+   190   190   190   190   190    /* CG,GU,A,G */+   300   300   300   190   300    /* CG,GU,A,U */+   300   300   300   300   300    /* CG,GU,C,E */+   300   300   300   300   300    /* CG,GU,C,A */+   300   300   300   300   300    /* CG,GU,C,C */+   300   300   300   300   300    /* CG,GU,C,G */+   300   300   300   300   300    /* CG,GU,C,U */+   300   190   300   190   300    /* CG,GU,G,E */+   300   190   300   190   300    /* CG,GU,G,A */+   300   190   300   190   300    /* CG,GU,G,C */+   190   190   190   190   190    /* CG,GU,G,G */+   300   190   300   190   300    /* CG,GU,G,U */+   300   300   300   300   220    /* CG,GU,U,E */+   300   300   300   300   220    /* CG,GU,U,A */+   300   300   300   300   220    /* CG,GU,U,C */+   300   300   300   300   220    /* CG,GU,U,G */+   220   220   220   220   220    /* CG,GU,U,U */+   300   300   300   300   300    /* CG,UG,E,E */+   300   300   300   300   300    /* CG,UG,E,A */+   300   300   300   300   300    /* CG,UG,E,C */+   300   300   300   300   300    /* CG,UG,E,G */+   300   300   300   300   300    /* CG,UG,E,U */+   300   300   300   190   300    /* CG,UG,A,E */+   300   300   300   190   300    /* CG,UG,A,A */+   300   300   300   190   300    /* CG,UG,A,C */+   190   190   190   190   190    /* CG,UG,A,G */+   300   300   300   190   300    /* CG,UG,A,U */+   300   300   300   300   300    /* CG,UG,C,E */+   300   300   300   300   300    /* CG,UG,C,A */+   300   300   300   300   300    /* CG,UG,C,C */+   300   300   300   300   300    /* CG,UG,C,G */+   300   300   300   300   300    /* CG,UG,C,U */+   300   190   300   190   300    /* CG,UG,G,E */+   190   190   190   190   190    /* CG,UG,G,A */+   300   190   300   190   300    /* CG,UG,G,C */+   190   190   190   190   190    /* CG,UG,G,G */+   300   190   300   190   300    /* CG,UG,G,U */+   300   300   300   300   220    /* CG,UG,U,E */+   300   300   300   300   220    /* CG,UG,U,A */+   300   300   300   300   220    /* CG,UG,U,C */+   300   300   300   300   220    /* CG,UG,U,G */+   220   220   220   220   220    /* CG,UG,U,U */+   300   300   300   300   300    /* CG,AU,E,E */+   300   300   300   300   300    /* CG,AU,E,A */+   300   300   300   300   300    /* CG,AU,E,C */+   300   300   300   300   300    /* CG,AU,E,G */+   300   300   300   300   300    /* CG,AU,E,U */+   300   300   300   190   300    /* CG,AU,A,E */+   300   300   300   190   300    /* CG,AU,A,A */+   300   300   300   190   300    /* CG,AU,A,C */+   190   190   190   190   190    /* CG,AU,A,G */+   300   300   300   190   300    /* CG,AU,A,U */+   300   300   300   300   300    /* CG,AU,C,E */+   300   300   300   300   300    /* CG,AU,C,A */+   300   300   300   300   300    /* CG,AU,C,C */+   300   300   300   300   300    /* CG,AU,C,G */+   300   300   300   300   300    /* CG,AU,C,U */+   300   190   300   190   300    /* CG,AU,G,E */+   300   190   300   190   300    /* CG,AU,G,A */+   300   190   300   190   300    /* CG,AU,G,C */+   190   190   190   190   190    /* CG,AU,G,G */+   300   190   300   190   300    /* CG,AU,G,U */+   300   300   300   300   220    /* CG,AU,U,E */+   300   300   300   300   220    /* CG,AU,U,A */+   300   300   300   300   220    /* CG,AU,U,C */+   300   300   300   300   220    /* CG,AU,U,G */+   220   220   220   220   220    /* CG,AU,U,U */+   300   300   300   300   300    /* CG,UA,E,E */+   300   300   300   300   300    /* CG,UA,E,A */+   300   300   300   300   300    /* CG,UA,E,C */+   300   300   300   300   300    /* CG,UA,E,G */+   300   300   300   300   300    /* CG,UA,E,U */+   300   300   300   190   300    /* CG,UA,A,E */+   300   300   300   190   300    /* CG,UA,A,A */+   300   300   300   190   300    /* CG,UA,A,C */+   190   190   190   190   190    /* CG,UA,A,G */+   300   300   300   190   300    /* CG,UA,A,U */+   300   300   300   300   300    /* CG,UA,C,E */+   300   300   300   300   300    /* CG,UA,C,A */+   300   300   300   300   300    /* CG,UA,C,C */+   300   300   300   300   300    /* CG,UA,C,G */+   300   300   300   300   300    /* CG,UA,C,U */+   300   190   300   190   300    /* CG,UA,G,E */+   190   190   190   190   190    /* CG,UA,G,A */+   300   190   300   190   300    /* CG,UA,G,C */+   190   190   190   190   190    /* CG,UA,G,G */+   300   190   300   190   300    /* CG,UA,G,U */+   300   300   300   300   220    /* CG,UA,U,E */+   300   300   300   300   220    /* CG,UA,U,A */+   300   300   300   300   220    /* CG,UA,U,C */+   300   300   300   300   220    /* CG,UA,U,G */+   220   220   220   220   220    /* CG,UA,U,U */+   300   300   300   300   300    /* CG,NS,E,E */+   300   300   300   300   300    /* CG,NS,E,A */+   300   300   300   300   300    /* CG,NS,E,C */+   300   300   300   300   300    /* CG,NS,E,G */+   300   300   300   300   300    /* CG,NS,E,U */+   300   300   300   190   300    /* CG,NS,A,E */+   300   300   300   190   300    /* CG,NS,A,A */+   300   300   300   190   300    /* CG,NS,A,C */+   190   190   190   190   190    /* CG,NS,A,G */+   300   300   300   190   300    /* CG,NS,A,U */+   300   300   300   300   300    /* CG,NS,C,E */+   300   300   300   300   300    /* CG,NS,C,A */+   300   300   300   300   300    /* CG,NS,C,C */+   300   300   300   300   300    /* CG,NS,C,G */+   300   300   300   300   300    /* CG,NS,C,U */+   300   190   300   190   300    /* CG,NS,G,E */+   300   190   300   190   300    /* CG,NS,G,A */+   300   190   300   190   300    /* CG,NS,G,C */+   190   190   190   190   190    /* CG,NS,G,G */+   300   190   300   190   300    /* CG,NS,G,U */+   300   300   300   300   220    /* CG,NS,U,E */+   300   300   300   300   220    /* CG,NS,U,A */+   300   300   300   300   220    /* CG,NS,U,C */+   300   300   300   300   220    /* CG,NS,U,G */+   220   220   220   220   220    /* CG,NS,U,U */+   250   250   230   230   230    /* GC,CG,E,E */+   250   250   230   230   230    /* GC,CG,E,A */+   230   230   230   230   230    /* GC,CG,E,C */+   230   230   230   230   230    /* GC,CG,E,G */+   230   230   230   230   230    /* GC,CG,E,U */+   250   250   230   230   230    /* GC,CG,A,E */+   250   250   230   210   230    /* GC,CG,A,A */+   230   230   230   230   230    /* GC,CG,A,C */+   120   120   110   110   110    /* GC,CG,A,G */+   230   230   230   230   230    /* GC,CG,A,U */+   230   230   230   230   230    /* GC,CG,C,E */+   230   230   230   230   230    /* GC,CG,C,A */+   230   230   230   230   230    /* GC,CG,C,C */+   230   230   230   230   230    /* GC,CG,C,G */+   230   230   190   230   230    /* GC,CG,C,U */+   230   110   230   110   230    /* GC,CG,G,E */+   110   110   110   110   110    /* GC,CG,G,A */+   230   110   230   110   230    /* GC,CG,G,C */+   110   110   110   110   110    /* GC,CG,G,G */+   230   110   230   110   230    /* GC,CG,G,U */+   230   230   230   230   150    /* GC,CG,U,E */+   230   230   230   230   150    /* GC,CG,U,A */+   230   230   230   230   150    /* GC,CG,U,C */+   230   230   230   230   150    /* GC,CG,U,G */+   150   150   150   150   150    /* GC,CG,U,U */+   230   230   230   230   230    /* GC,GC,E,E */+   230   230   230   230   230    /* GC,GC,E,A */+   230   230   230   230   230    /* GC,GC,E,C */+   230   230   230   230   230    /* GC,GC,E,G */+   230   230   230   230   230    /* GC,GC,E,U */+   230   230   230   230   230    /* GC,GC,A,E */+   230   230   230   230   230    /* GC,GC,A,A */+   230   230   230   230   230    /* GC,GC,A,C */+   110   110   110   110   110    /* GC,GC,A,G */+   230   230   230   230   230    /* GC,GC,A,U */+   230   230   230   230   230    /* GC,GC,C,E */+   230   230   230   230   230    /* GC,GC,C,A */+   230   230   230   230   230    /* GC,GC,C,C */+   230   230   230   230   230    /* GC,GC,C,G */+   230   230   230   230   230    /* GC,GC,C,U */+   230   110   230   110   230    /* GC,GC,G,E */+   230   110   230   110   230    /* GC,GC,G,A */+   230   110   230   110   230    /* GC,GC,G,C */+   110   110   110   110   110    /* GC,GC,G,G */+   230   110   230   110   230    /* GC,GC,G,U */+   230   230   230   230   150    /* GC,GC,U,E */+   230   230   230   230   150    /* GC,GC,U,A */+   230   230   230   230   150    /* GC,GC,U,C */+   230   230   230   230   150    /* GC,GC,U,G */+   150   150   150   150   150    /* GC,GC,U,U */+   300   300   300   300   300    /* GC,GU,E,E */+   300   300   300   300   300    /* GC,GU,E,A */+   300   300   300   300   300    /* GC,GU,E,C */+   300   300   300   300   300    /* GC,GU,E,G */+   300   300   300   300   300    /* GC,GU,E,U */+   300   300   300   300   300    /* GC,GU,A,E */+   300   300   300   300   300    /* GC,GU,A,A */+   300   300   300   300   300    /* GC,GU,A,C */+   190   190   190   190   190    /* GC,GU,A,G */+   300   300   300   300   300    /* GC,GU,A,U */+   300   300   300   300   300    /* GC,GU,C,E */+   300   300   300   300   300    /* GC,GU,C,A */+   300   300   300   300   300    /* GC,GU,C,C */+   300   300   300   300   300    /* GC,GU,C,G */+   300   300   300   300   300    /* GC,GU,C,U */+   300   190   300   190   300    /* GC,GU,G,E */+   300   190   300   190   300    /* GC,GU,G,A */+   300   190   300   190   300    /* GC,GU,G,C */+   190   190   190   190   190    /* GC,GU,G,G */+   300   190   300   190   300    /* GC,GU,G,U */+   300   300   300   300   220    /* GC,GU,U,E */+   300   300   300   300   220    /* GC,GU,U,A */+   300   300   300   300   220    /* GC,GU,U,C */+   300   300   300   300   220    /* GC,GU,U,G */+   220   220   220   220   220    /* GC,GU,U,U */+   300   300   300   300   300    /* GC,UG,E,E */+   300   300   300   300   300    /* GC,UG,E,A */+   300   300   300   300   300    /* GC,UG,E,C */+   300   300   300   300   300    /* GC,UG,E,G */+   300   300   300   300   300    /* GC,UG,E,U */+   300   300   300   300   300    /* GC,UG,A,E */+   300   250   300   210   300    /* GC,UG,A,A */+   300   300   300   300   300    /* GC,UG,A,C */+   190   120   190   190   190    /* GC,UG,A,G */+   300   300   300   300   300    /* GC,UG,A,U */+   300   300   300   300   300    /* GC,UG,C,E */+   300   300   300   300   300    /* GC,UG,C,A */+   300   300   300   300   300    /* GC,UG,C,C */+   300   300   300   300   300    /* GC,UG,C,G */+   300   300   190   300   300    /* GC,UG,C,U */+   300   190   300   190   300    /* GC,UG,G,E */+   190   190   190   190   190    /* GC,UG,G,A */+   300   190   300   190   300    /* GC,UG,G,C */+   190   190   190   190   190    /* GC,UG,G,G */+   300   190   300   190   300    /* GC,UG,G,U */+   300   300   300   300   220    /* GC,UG,U,E */+   300   300   300   300   220    /* GC,UG,U,A */+   300   300   300   300   220    /* GC,UG,U,C */+   300   300   300   300   220    /* GC,UG,U,G */+   220   220   220   220   220    /* GC,UG,U,U */+   300   300   300   300   300    /* GC,AU,E,E */+   300   300   300   300   300    /* GC,AU,E,A */+   300   300   300   300   300    /* GC,AU,E,C */+   300   300   300   300   300    /* GC,AU,E,G */+   300   300   300   300   300    /* GC,AU,E,U */+   300   300   300   300   300    /* GC,AU,A,E */+   300   300   300   300   300    /* GC,AU,A,A */+   300   300   300   300   300    /* GC,AU,A,C */+   190   190   190   190   190    /* GC,AU,A,G */+   300   300   300   300   300    /* GC,AU,A,U */+   300   300   300   300   300    /* GC,AU,C,E */+   300   300   300   300   300    /* GC,AU,C,A */+   300   300   300   300   300    /* GC,AU,C,C */+   300   300   300   300   300    /* GC,AU,C,G */+   300   300   300   300   300    /* GC,AU,C,U */+   300   190   300   190   300    /* GC,AU,G,E */+   300   190   300   190   300    /* GC,AU,G,A */+   300   190   300   190   300    /* GC,AU,G,C */+   190   190   190   190   190    /* GC,AU,G,G */+   300   190   300   190   300    /* GC,AU,G,U */+   300   300   300   300   220    /* GC,AU,U,E */+   300   300   300   300   220    /* GC,AU,U,A */+   300   300   300   300   220    /* GC,AU,U,C */+   300   300   300   300   220    /* GC,AU,U,G */+   220   220   220   220   220    /* GC,AU,U,U */+   300   300   300   300   300    /* GC,UA,E,E */+   300   300   300   300   300    /* GC,UA,E,A */+   300   300   300   300   300    /* GC,UA,E,C */+   300   300   300   300   300    /* GC,UA,E,G */+   300   300   300   300   300    /* GC,UA,E,U */+   300   300   300   300   300    /* GC,UA,A,E */+   300   300   300   300   300    /* GC,UA,A,A */+   300   300   300   300   300    /* GC,UA,A,C */+   190   190   190   190   190    /* GC,UA,A,G */+   300   300   300   300   300    /* GC,UA,A,U */+   300   300   300   300   300    /* GC,UA,C,E */+   300   300   300   300   300    /* GC,UA,C,A */+   300   300   300   300   300    /* GC,UA,C,C */+   300   300   300   300   300    /* GC,UA,C,G */+   300   300   300   300   300    /* GC,UA,C,U */+   300   190   300   190   300    /* GC,UA,G,E */+   190   190   190   190   190    /* GC,UA,G,A */+   300   190   300   190   300    /* GC,UA,G,C */+   190   190   190   190   190    /* GC,UA,G,G */+   300   190   300   190   300    /* GC,UA,G,U */+   300   300   300   300   220    /* GC,UA,U,E */+   300   300   300   300   220    /* GC,UA,U,A */+   300   300   300   300   220    /* GC,UA,U,C */+   300   300   300   300   220    /* GC,UA,U,G */+   220   220   220   220   220    /* GC,UA,U,U */+   300   300   300   300   300    /* GC,NS,E,E */+   300   300   300   300   300    /* GC,NS,E,A */+   300   300   300   300   300    /* GC,NS,E,C */+   300   300   300   300   300    /* GC,NS,E,G */+   300   300   300   300   300    /* GC,NS,E,U */+   300   300   300   300   300    /* GC,NS,A,E */+   300   300   300   300   300    /* GC,NS,A,A */+   300   300   300   300   300    /* GC,NS,A,C */+   190   190   190   190   190    /* GC,NS,A,G */+   300   300   300   300   300    /* GC,NS,A,U */+   300   300   300   300   300    /* GC,NS,C,E */+   300   300   300   300   300    /* GC,NS,C,A */+   300   300   300   300   300    /* GC,NS,C,C */+   300   300   300   300   300    /* GC,NS,C,G */+   300   300   300   300   300    /* GC,NS,C,U */+   300   190   300   190   300    /* GC,NS,G,E */+   300   190   300   190   300    /* GC,NS,G,A */+   300   190   300   190   300    /* GC,NS,G,C */+   190   190   190   190   190    /* GC,NS,G,G */+   300   190   300   190   300    /* GC,NS,G,U */+   300   300   300   300   220    /* GC,NS,U,E */+   300   300   300   300   220    /* GC,NS,U,A */+   300   300   300   300   220    /* GC,NS,U,C */+   300   300   300   300   220    /* GC,NS,U,G */+   220   220   220   220   220    /* GC,NS,U,U */+   300   300   300   300   300    /* GU,CG,E,E */+   300   300   300   300   300    /* GU,CG,E,A */+   300   300   300   300   300    /* GU,CG,E,C */+   300   300   300   300   300    /* GU,CG,E,G */+   300   300   300   300   300    /* GU,CG,E,U */+   300   300   300   300   300    /* GU,CG,A,E */+   300   250   300   210   300    /* GU,CG,A,A */+   300   300   300   300   300    /* GU,CG,A,C */+   190   120   190   190   190    /* GU,CG,A,G */+   300   300   300   300   300    /* GU,CG,A,U */+   300   300   300   300   300    /* GU,CG,C,E */+   300   300   300   300   300    /* GU,CG,C,A */+   300   300   300   300   300    /* GU,CG,C,C */+   300   300   300   300   300    /* GU,CG,C,G */+   300   300   190   300   300    /* GU,CG,C,U */+   300   190   300   190   300    /* GU,CG,G,E */+   190   190   190   190   190    /* GU,CG,G,A */+   300   190   300   190   300    /* GU,CG,G,C */+   190   190   190   190   190    /* GU,CG,G,G */+   300   190   300   190   300    /* GU,CG,G,U */+   300   300   300   300   220    /* GU,CG,U,E */+   300   300   300   300   220    /* GU,CG,U,A */+   300   300   300   300   220    /* GU,CG,U,C */+   300   300   300   300   220    /* GU,CG,U,G */+   220   220   220   220   220    /* GU,CG,U,U */+   300   300   300   300   300    /* GU,GC,E,E */+   300   300   300   300   300    /* GU,GC,E,A */+   300   300   300   300   300    /* GU,GC,E,C */+   300   300   300   300   300    /* GU,GC,E,G */+   300   300   300   300   300    /* GU,GC,E,U */+   300   300   300   300   300    /* GU,GC,A,E */+   300   300   300   300   300    /* GU,GC,A,A */+   300   300   300   300   300    /* GU,GC,A,C */+   190   190   190   190   190    /* GU,GC,A,G */+   300   300   300   300   300    /* GU,GC,A,U */+   300   300   300   300   300    /* GU,GC,C,E */+   300   300   300   300   300    /* GU,GC,C,A */+   300   300   300   300   300    /* GU,GC,C,C */+   300   300   300   300   300    /* GU,GC,C,G */+   300   300   300   300   300    /* GU,GC,C,U */+   300   190   300   190   300    /* GU,GC,G,E */+   300   190   300   190   300    /* GU,GC,G,A */+   300   190   300   190   300    /* GU,GC,G,C */+   190   190   190   190   190    /* GU,GC,G,G */+   300   190   300   190   300    /* GU,GC,G,U */+   300   300   300   300   220    /* GU,GC,U,E */+   300   300   300   300   220    /* GU,GC,U,A */+   300   300   300   300   220    /* GU,GC,U,C */+   300   300   300   300   220    /* GU,GC,U,G */+   220   220   220   220   220    /* GU,GC,U,U */+   370   370   370   370   370    /* GU,GU,E,E */+   370   370   370   370   370    /* GU,GU,E,A */+   370   370   370   370   370    /* GU,GU,E,C */+   370   370   370   370   370    /* GU,GU,E,G */+   370   370   370   370   370    /* GU,GU,E,U */+   370   370   370   370   370    /* GU,GU,A,E */+   370   370   370   370   370    /* GU,GU,A,A */+   370   370   370   370   370    /* GU,GU,A,C */+   260   260   260   260   260    /* GU,GU,A,G */+   370   370   370   370   370    /* GU,GU,A,U */+   370   370   370   370   370    /* GU,GU,C,E */+   370   370   370   370   370    /* GU,GU,C,A */+   370   370   370   370   370    /* GU,GU,C,C */+   370   370   370   370   370    /* GU,GU,C,G */+   370   370   370   370   370    /* GU,GU,C,U */+   370   260   370   260   370    /* GU,GU,G,E */+   370   260   370   260   370    /* GU,GU,G,A */+   370   260   370   260   370    /* GU,GU,G,C */+   260   260   260   260   260    /* GU,GU,G,G */+   370   260   370   260   370    /* GU,GU,G,U */+   370   370   370   370   300    /* GU,GU,U,E */+   370   370   370   370   300    /* GU,GU,U,A */+   370   370   370   370   300    /* GU,GU,U,C */+   370   370   370   370   300    /* GU,GU,U,G */+   300   300   300   300   300    /* GU,GU,U,U */+   370   370   370   370   370    /* GU,UG,E,E */+   370   370   370   370   370    /* GU,UG,E,A */+   370   370   370   370   370    /* GU,UG,E,C */+   370   370   370   370   370    /* GU,UG,E,G */+   370   370   370   370   370    /* GU,UG,E,U */+   370   370   370   370   370    /* GU,UG,A,E */+   370   250   370   210   370    /* GU,UG,A,A */+   370   370   370   370   370    /* GU,UG,A,C */+   260   120   260   260   260    /* GU,UG,A,G */+   370   370   370   370   370    /* GU,UG,A,U */+   370   370   370   370   370    /* GU,UG,C,E */+   370   370   370   370   370    /* GU,UG,C,A */+   370   370   370   370   370    /* GU,UG,C,C */+   370   370   370   370   370    /* GU,UG,C,G */+   370   370   190   370   370    /* GU,UG,C,U */+   370   260   370   260   370    /* GU,UG,G,E */+   260   260   260   260   260    /* GU,UG,G,A */+   370   260   370   260   370    /* GU,UG,G,C */+   260   260   260   260   260    /* GU,UG,G,G */+   370   260   370   260   370    /* GU,UG,G,U */+   370   370   370   370   300    /* GU,UG,U,E */+   370   370   370   370   300    /* GU,UG,U,A */+   370   370   370   370   300    /* GU,UG,U,C */+   370   370   370   370   300    /* GU,UG,U,G */+   300   300   300   300   300    /* GU,UG,U,U */+   370   370   370   370   370    /* GU,AU,E,E */+   370   370   370   370   370    /* GU,AU,E,A */+   370   370   370   370   370    /* GU,AU,E,C */+   370   370   370   370   370    /* GU,AU,E,G */+   370   370   370   370   370    /* GU,AU,E,U */+   370   370   370   370   370    /* GU,AU,A,E */+   370   370   370   370   370    /* GU,AU,A,A */+   370   370   370   370   370    /* GU,AU,A,C */+   260   260   260   260   260    /* GU,AU,A,G */+   370   370   370   370   370    /* GU,AU,A,U */+   370   370   370   370   370    /* GU,AU,C,E */+   370   370   370   370   370    /* GU,AU,C,A */+   370   370   370   370   370    /* GU,AU,C,C */+   370   370   370   370   370    /* GU,AU,C,G */+   370   370   370   370   370    /* GU,AU,C,U */+   370   260   370   260   370    /* GU,AU,G,E */+   370   260   370   260   370    /* GU,AU,G,A */+   370   260   370   260   370    /* GU,AU,G,C */+   260   260   260   260   260    /* GU,AU,G,G */+   370   260   370   260   370    /* GU,AU,G,U */+   370   370   370   370   300    /* GU,AU,U,E */+   370   370   370   370   300    /* GU,AU,U,A */+   370   370   370   370   300    /* GU,AU,U,C */+   370   370   370   370   300    /* GU,AU,U,G */+   300   300   300   300   300    /* GU,AU,U,U */+   370   370   370   370   370    /* GU,UA,E,E */+   370   370   370   370   370    /* GU,UA,E,A */+   370   370   370   370   370    /* GU,UA,E,C */+   370   370   370   370   370    /* GU,UA,E,G */+   370   370   370   370   370    /* GU,UA,E,U */+   370   370   370   370   370    /* GU,UA,A,E */+   370   370   370   370   370    /* GU,UA,A,A */+   370   370   370   370   370    /* GU,UA,A,C */+   260   260   260   260   260    /* GU,UA,A,G */+   370   370   370   370   370    /* GU,UA,A,U */+   370   370   370   370   370    /* GU,UA,C,E */+   370   370   370   370   370    /* GU,UA,C,A */+   370   370   370   370   370    /* GU,UA,C,C */+   370   370   370   370   370    /* GU,UA,C,G */+   370   370   370   370   370    /* GU,UA,C,U */+   370   260   370   260   370    /* GU,UA,G,E */+   260   260   260   260   260    /* GU,UA,G,A */+   370   260   370   260   370    /* GU,UA,G,C */+   260   260   260   260   260    /* GU,UA,G,G */+   370   260   370   260   370    /* GU,UA,G,U */+   370   370   370   370   300    /* GU,UA,U,E */+   370   370   370   370   300    /* GU,UA,U,A */+   370   370   370   370   300    /* GU,UA,U,C */+   370   370   370   370   300    /* GU,UA,U,G */+   300   300   300   300   300    /* GU,UA,U,U */+   370   370   370   370   370    /* GU,NS,E,E */+   370   370   370   370   370    /* GU,NS,E,A */+   370   370   370   370   370    /* GU,NS,E,C */+   370   370   370   370   370    /* GU,NS,E,G */+   370   370   370   370   370    /* GU,NS,E,U */+   370   370   370   370   370    /* GU,NS,A,E */+   370   370   370   370   370    /* GU,NS,A,A */+   370   370   370   370   370    /* GU,NS,A,C */+   260   260   260   260   260    /* GU,NS,A,G */+   370   370   370   370   370    /* GU,NS,A,U */+   370   370   370   370   370    /* GU,NS,C,E */+   370   370   370   370   370    /* GU,NS,C,A */+   370   370   370   370   370    /* GU,NS,C,C */+   370   370   370   370   370    /* GU,NS,C,G */+   370   370   370   370   370    /* GU,NS,C,U */+   370   260   370   260   370    /* GU,NS,G,E */+   370   260   370   260   370    /* GU,NS,G,A */+   370   260   370   260   370    /* GU,NS,G,C */+   260   260   260   260   260    /* GU,NS,G,G */+   370   260   370   260   370    /* GU,NS,G,U */+   370   370   370   370   300    /* GU,NS,U,E */+   370   370   370   370   300    /* GU,NS,U,A */+   370   370   370   370   300    /* GU,NS,U,C */+   370   370   370   370   300    /* GU,NS,U,G */+   300   300   300   300   300    /* GU,NS,U,U */+   300   300   300   300   300    /* UG,CG,E,E */+   300   300   300   300   300    /* UG,CG,E,A */+   300   300   300   300   300    /* UG,CG,E,C */+   300   300   300   300   300    /* UG,CG,E,G */+   300   300   300   300   300    /* UG,CG,E,U */+   300   300   300   190   300    /* UG,CG,A,E */+   300   300   300   190   300    /* UG,CG,A,A */+   300   300   300   190   300    /* UG,CG,A,C */+   190   190   190   190   190    /* UG,CG,A,G */+   300   300   300   190   300    /* UG,CG,A,U */+   300   300   300   300   300    /* UG,CG,C,E */+   300   300   300   300   300    /* UG,CG,C,A */+   300   300   300   300   300    /* UG,CG,C,C */+   300   300   300   300   300    /* UG,CG,C,G */+   300   300   300   300   300    /* UG,CG,C,U */+   300   190   300   190   300    /* UG,CG,G,E */+   190   190   190   190   190    /* UG,CG,G,A */+   300   190   300   190   300    /* UG,CG,G,C */+   190   190   190   190   190    /* UG,CG,G,G */+   300   190   300   190   300    /* UG,CG,G,U */+   300   300   300   300   220    /* UG,CG,U,E */+   300   300   300   300   220    /* UG,CG,U,A */+   300   300   300   300   220    /* UG,CG,U,C */+   300   300   300   300   220    /* UG,CG,U,G */+   220   220   220   220   220    /* UG,CG,U,U */+   300   300   300   300   300    /* UG,GC,E,E */+   300   300   300   300   300    /* UG,GC,E,A */+   300   300   300   300   300    /* UG,GC,E,C */+   300   300   300   300   300    /* UG,GC,E,G */+   300   300   300   300   300    /* UG,GC,E,U */+   300   300   300   190   300    /* UG,GC,A,E */+   300   300   300   190   300    /* UG,GC,A,A */+   300   300   300   190   300    /* UG,GC,A,C */+   190   190   190   190   190    /* UG,GC,A,G */+   300   300   300   190   300    /* UG,GC,A,U */+   300   300   300   300   300    /* UG,GC,C,E */+   300   300   300   300   300    /* UG,GC,C,A */+   300   300   300   300   300    /* UG,GC,C,C */+   300   300   300   300   300    /* UG,GC,C,G */+   300   300   300   300   300    /* UG,GC,C,U */+   300   190   300   190   300    /* UG,GC,G,E */+   300   190   300   190   300    /* UG,GC,G,A */+   300   190   300   190   300    /* UG,GC,G,C */+   190   190   190   190   190    /* UG,GC,G,G */+   300   190   300   190   300    /* UG,GC,G,U */+   300   300   300   300   220    /* UG,GC,U,E */+   300   300   300   300   220    /* UG,GC,U,A */+   300   300   300   300   220    /* UG,GC,U,C */+   300   300   300   300   220    /* UG,GC,U,G */+   220   220   220   220   220    /* UG,GC,U,U */+   370   370   370   370   370    /* UG,GU,E,E */+   370   370   370   370   370    /* UG,GU,E,A */+   370   370   370   370   370    /* UG,GU,E,C */+   370   370   370   370   370    /* UG,GU,E,G */+   370   370   370   370   370    /* UG,GU,E,U */+   370   370   370   260   370    /* UG,GU,A,E */+   370   370   370   260   370    /* UG,GU,A,A */+   370   370   370   260   370    /* UG,GU,A,C */+   260   260   260   260   260    /* UG,GU,A,G */+   370   370   370   260   370    /* UG,GU,A,U */+   370   370   370   370   370    /* UG,GU,C,E */+   370   370   370   370   370    /* UG,GU,C,A */+   370   370   370   370   370    /* UG,GU,C,C */+   370   370   370   370   370    /* UG,GU,C,G */+   370   370   370   370   370    /* UG,GU,C,U */+   370   260   370   260   370    /* UG,GU,G,E */+   370   260   370   260   370    /* UG,GU,G,A */+   370   260   370   260   370    /* UG,GU,G,C */+   260   260   260   260   260    /* UG,GU,G,G */+   370   260   370   260   370    /* UG,GU,G,U */+   370   370   370   370   300    /* UG,GU,U,E */+   370   370   370   370   300    /* UG,GU,U,A */+   370   370   370   370   300    /* UG,GU,U,C */+   370   370   370   370   300    /* UG,GU,U,G */+   300   300   300   300   300    /* UG,GU,U,U */+   370   370   370   370   370    /* UG,UG,E,E */+   370   370   370   370   370    /* UG,UG,E,A */+   370   370   370   370   370    /* UG,UG,E,C */+   370   370   370   370   370    /* UG,UG,E,G */+   370   370   370   370   370    /* UG,UG,E,U */+   370   370   370   260   370    /* UG,UG,A,E */+   370   370   370   260   370    /* UG,UG,A,A */+   370   370   370   260   370    /* UG,UG,A,C */+   260   260   260   260   260    /* UG,UG,A,G */+   370   370   370   260   370    /* UG,UG,A,U */+   370   370   370   370   370    /* UG,UG,C,E */+   370   370   370   370   370    /* UG,UG,C,A */+   370   370   370   370   370    /* UG,UG,C,C */+   370   370   370   370   370    /* UG,UG,C,G */+   370   370   370   370   370    /* UG,UG,C,U */+   370   260   370   260   370    /* UG,UG,G,E */+   260   260   260   260   260    /* UG,UG,G,A */+   370   260   370   260   370    /* UG,UG,G,C */+   260   260   260   260   260    /* UG,UG,G,G */+   370   260   370   260   370    /* UG,UG,G,U */+   370   370   370   370   300    /* UG,UG,U,E */+   370   370   370   370   300    /* UG,UG,U,A */+   370   370   370   370   300    /* UG,UG,U,C */+   370   370   370   370   300    /* UG,UG,U,G */+   300   300   300   300   300    /* UG,UG,U,U */+   370   370   370   370   370    /* UG,AU,E,E */+   370   370   370   370   370    /* UG,AU,E,A */+   370   370   370   370   370    /* UG,AU,E,C */+   370   370   370   370   370    /* UG,AU,E,G */+   370   370   370   370   370    /* UG,AU,E,U */+   370   370   370   260   370    /* UG,AU,A,E */+   370   370   370   260   370    /* UG,AU,A,A */+   370   370   370   260   370    /* UG,AU,A,C */+   260   260   260   260   260    /* UG,AU,A,G */+   370   370   370   260   370    /* UG,AU,A,U */+   370   370   370   370   370    /* UG,AU,C,E */+   370   370   370   370   370    /* UG,AU,C,A */+   370   370   370   370   370    /* UG,AU,C,C */+   370   370   370   370   370    /* UG,AU,C,G */+   370   370   370   370   370    /* UG,AU,C,U */+   370   260   370   260   370    /* UG,AU,G,E */+   370   260   370   260   370    /* UG,AU,G,A */+   370   260   370   260   370    /* UG,AU,G,C */+   260   260   260   260   260    /* UG,AU,G,G */+   370   260   370   260   370    /* UG,AU,G,U */+   370   370   370   370   300    /* UG,AU,U,E */+   370   370   370   370   300    /* UG,AU,U,A */+   370   370   370   370   300    /* UG,AU,U,C */+   370   370   370   370   300    /* UG,AU,U,G */+   300   300   300   300   300    /* UG,AU,U,U */+   370   370   370   370   370    /* UG,UA,E,E */+   370   370   370   370   370    /* UG,UA,E,A */+   370   370   370   370   370    /* UG,UA,E,C */+   370   370   370   370   370    /* UG,UA,E,G */+   370   370   370   370   370    /* UG,UA,E,U */+   370   370   370   260   370    /* UG,UA,A,E */+   370   370   370   260   370    /* UG,UA,A,A */+   370   370   370   260   370    /* UG,UA,A,C */+   260   260   260   260   260    /* UG,UA,A,G */+   370   370   370   260   370    /* UG,UA,A,U */+   370   370   370   370   370    /* UG,UA,C,E */+   370   370   370   370   370    /* UG,UA,C,A */+   370   370   370   370   370    /* UG,UA,C,C */+   370   370   370   370   370    /* UG,UA,C,G */+   370   370   370   370   370    /* UG,UA,C,U */+   370   260   370   260   370    /* UG,UA,G,E */+   260   260   260   260   260    /* UG,UA,G,A */+   370   260   370   260   370    /* UG,UA,G,C */+   260   260   260   260   260    /* UG,UA,G,G */+   370   260   370   260   370    /* UG,UA,G,U */+   370   370   370   370   300    /* UG,UA,U,E */+   370   370   370   370   300    /* UG,UA,U,A */+   370   370   370   370   300    /* UG,UA,U,C */+   370   370   370   370   300    /* UG,UA,U,G */+   300   300   300   300   300    /* UG,UA,U,U */+   370   370   370   370   370    /* UG,NS,E,E */+   370   370   370   370   370    /* UG,NS,E,A */+   370   370   370   370   370    /* UG,NS,E,C */+   370   370   370   370   370    /* UG,NS,E,G */+   370   370   370   370   370    /* UG,NS,E,U */+   370   370   370   260   370    /* UG,NS,A,E */+   370   370   370   260   370    /* UG,NS,A,A */+   370   370   370   260   370    /* UG,NS,A,C */+   260   260   260   260   260    /* UG,NS,A,G */+   370   370   370   260   370    /* UG,NS,A,U */+   370   370   370   370   370    /* UG,NS,C,E */+   370   370   370   370   370    /* UG,NS,C,A */+   370   370   370   370   370    /* UG,NS,C,C */+   370   370   370   370   370    /* UG,NS,C,G */+   370   370   370   370   370    /* UG,NS,C,U */+   370   260   370   260   370    /* UG,NS,G,E */+   370   260   370   260   370    /* UG,NS,G,A */+   370   260   370   260   370    /* UG,NS,G,C */+   260   260   260   260   260    /* UG,NS,G,G */+   370   260   370   260   370    /* UG,NS,G,U */+   370   370   370   370   300    /* UG,NS,U,E */+   370   370   370   370   300    /* UG,NS,U,A */+   370   370   370   370   300    /* UG,NS,U,C */+   370   370   370   370   300    /* UG,NS,U,G */+   300   300   300   300   300    /* UG,NS,U,U */+   300   300   300   300   300    /* AU,CG,E,E */+   300   300   300   300   300    /* AU,CG,E,A */+   300   300   300   300   300    /* AU,CG,E,C */+   300   300   300   300   300    /* AU,CG,E,G */+   300   300   300   300   300    /* AU,CG,E,U */+   300   300   300   300   300    /* AU,CG,A,E */+   300   300   300   300   300    /* AU,CG,A,A */+   300   300   300   300   300    /* AU,CG,A,C */+   190   190   190   190   190    /* AU,CG,A,G */+   300   300   300   300   300    /* AU,CG,A,U */+   300   300   300   300   300    /* AU,CG,C,E */+   300   300   300   300   300    /* AU,CG,C,A */+   300   300   300   300   300    /* AU,CG,C,C */+   300   300   300   300   300    /* AU,CG,C,G */+   300   300   300   300   300    /* AU,CG,C,U */+   300   190   300   190   300    /* AU,CG,G,E */+   190   190   190   190   190    /* AU,CG,G,A */+   300   190   300   190   300    /* AU,CG,G,C */+   190   190   190   190   190    /* AU,CG,G,G */+   300   190   300   190   300    /* AU,CG,G,U */+   300   300   300   300   220    /* AU,CG,U,E */+   300   300   300   300   220    /* AU,CG,U,A */+   300   300   300   300   220    /* AU,CG,U,C */+   300   300   300   300   220    /* AU,CG,U,G */+   220   220   220   220   220    /* AU,CG,U,U */+   300   300   300   300   300    /* AU,GC,E,E */+   300   300   300   300   300    /* AU,GC,E,A */+   300   300   300   300   300    /* AU,GC,E,C */+   300   300   300   300   300    /* AU,GC,E,G */+   300   300   300   300   300    /* AU,GC,E,U */+   300   300   300   300   300    /* AU,GC,A,E */+   300   300   300   300   300    /* AU,GC,A,A */+   300   300   300   300   300    /* AU,GC,A,C */+   190   190   190   190   190    /* AU,GC,A,G */+   300   300   300   300   300    /* AU,GC,A,U */+   300   300   300   300   300    /* AU,GC,C,E */+   300   300   300   300   300    /* AU,GC,C,A */+   300   300   300   300   300    /* AU,GC,C,C */+   300   300   300   300   300    /* AU,GC,C,G */+   300   300   300   300   300    /* AU,GC,C,U */+   300   190   300   190   300    /* AU,GC,G,E */+   300   190   300   190   300    /* AU,GC,G,A */+   300   190   300   190   300    /* AU,GC,G,C */+   190   190   190   190   190    /* AU,GC,G,G */+   300   190   300   190   300    /* AU,GC,G,U */+   300   300   300   300   220    /* AU,GC,U,E */+   300   300   300   300   220    /* AU,GC,U,A */+   300   300   300   300   220    /* AU,GC,U,C */+   300   300   300   300   220    /* AU,GC,U,G */+   220   220   220   220   220    /* AU,GC,U,U */+   370   370   370   370   370    /* AU,GU,E,E */+   370   370   370   370   370    /* AU,GU,E,A */+   370   370   370   370   370    /* AU,GU,E,C */+   370   370   370   370   370    /* AU,GU,E,G */+   370   370   370   370   370    /* AU,GU,E,U */+   370   370   370   370   370    /* AU,GU,A,E */+   370   370   370   370   370    /* AU,GU,A,A */+   370   370   370   370   370    /* AU,GU,A,C */+   260   260   260   260   260    /* AU,GU,A,G */+   370   370   370   370   370    /* AU,GU,A,U */+   370   370   370   370   370    /* AU,GU,C,E */+   370   370   370   370   370    /* AU,GU,C,A */+   370   370   370   370   370    /* AU,GU,C,C */+   370   370   370   370   370    /* AU,GU,C,G */+   370   370   370   370   370    /* AU,GU,C,U */+   370   260   370   260   370    /* AU,GU,G,E */+   370   260   370   260   370    /* AU,GU,G,A */+   370   260   370   260   370    /* AU,GU,G,C */+   260   260   260   260   260    /* AU,GU,G,G */+   370   260   370   260   370    /* AU,GU,G,U */+   370   370   370   370   300    /* AU,GU,U,E */+   370   370   370   370   300    /* AU,GU,U,A */+   370   370   370   370   300    /* AU,GU,U,C */+   370   370   370   370   300    /* AU,GU,U,G */+   300   300   300   300   300    /* AU,GU,U,U */+   370   370   370   370   370    /* AU,UG,E,E */+   370   370   370   370   370    /* AU,UG,E,A */+   370   370   370   370   370    /* AU,UG,E,C */+   370   370   370   370   370    /* AU,UG,E,G */+   370   370   370   370   370    /* AU,UG,E,U */+   370   370   370   370   370    /* AU,UG,A,E */+   370   370   370   370   370    /* AU,UG,A,A */+   370   370   370   370   370    /* AU,UG,A,C */+   260   260   260   260   260    /* AU,UG,A,G */+   370   370   370   370   370    /* AU,UG,A,U */+   370   370   370   370   370    /* AU,UG,C,E */+   370   370   370   370   370    /* AU,UG,C,A */+   370   370   370   370   370    /* AU,UG,C,C */+   370   370   370   370   370    /* AU,UG,C,G */+   370   370   370   370   370    /* AU,UG,C,U */+   370   260   370   260   370    /* AU,UG,G,E */+   260   260   260   260   260    /* AU,UG,G,A */+   370   260   370   260   370    /* AU,UG,G,C */+   260   260   260   260   260    /* AU,UG,G,G */+   370   260   370   260   370    /* AU,UG,G,U */+   370   370   370   370   300    /* AU,UG,U,E */+   370   370   370   370   300    /* AU,UG,U,A */+   370   370   370   370   300    /* AU,UG,U,C */+   370   370   370   370   300    /* AU,UG,U,G */+   300   300   300   300   300    /* AU,UG,U,U */+   370   370   370   370   370    /* AU,AU,E,E */+   370   370   370   370   370    /* AU,AU,E,A */+   370   370   370   370   370    /* AU,AU,E,C */+   370   370   370   370   370    /* AU,AU,E,G */+   370   370   370   370   370    /* AU,AU,E,U */+   370   370   370   370   370    /* AU,AU,A,E */+   370   370   370   370   370    /* AU,AU,A,A */+   370   370   370   370   370    /* AU,AU,A,C */+   260   260   260   260   260    /* AU,AU,A,G */+   370   370   370   370   370    /* AU,AU,A,U */+   370   370   370   370   370    /* AU,AU,C,E */+   370   370   370   370   370    /* AU,AU,C,A */+   370   370   370   370   370    /* AU,AU,C,C */+   370   370   370   370   370    /* AU,AU,C,G */+   370   370   370   370   370    /* AU,AU,C,U */+   370   260   370   260   370    /* AU,AU,G,E */+   370   260   370   260   370    /* AU,AU,G,A */+   370   260   370   260   370    /* AU,AU,G,C */+   260   260   260   260   260    /* AU,AU,G,G */+   370   260   370   260   370    /* AU,AU,G,U */+   370   370   370   370   300    /* AU,AU,U,E */+   370   370   370   370   300    /* AU,AU,U,A */+   370   370   370   370   300    /* AU,AU,U,C */+   370   370   370   370   300    /* AU,AU,U,G */+   300   300   300   300   300    /* AU,AU,U,U */+   370   370   370   370   370    /* AU,UA,E,E */+   370   370   370   370   370    /* AU,UA,E,A */+   370   370   370   370   370    /* AU,UA,E,C */+   370   370   370   370   370    /* AU,UA,E,G */+   370   370   370   370   370    /* AU,UA,E,U */+   370   370   370   370   370    /* AU,UA,A,E */+   370   370   370   370   370    /* AU,UA,A,A */+   370   370   370   370   370    /* AU,UA,A,C */+   260   260   260   260   260    /* AU,UA,A,G */+   370   370   370   370   370    /* AU,UA,A,U */+   370   370   370   370   370    /* AU,UA,C,E */+   370   370   370   370   370    /* AU,UA,C,A */+   370   370   370   370   370    /* AU,UA,C,C */+   370   370   370   370   370    /* AU,UA,C,G */+   370   370   370   370   370    /* AU,UA,C,U */+   370   260   370   260   370    /* AU,UA,G,E */+   260   260   260   260   260    /* AU,UA,G,A */+   370   260   370   260   370    /* AU,UA,G,C */+   260   260   260   260   260    /* AU,UA,G,G */+   370   260   370   260   370    /* AU,UA,G,U */+   370   370   370   370   300    /* AU,UA,U,E */+   370   370   370   370   300    /* AU,UA,U,A */+   370   370   370   370   300    /* AU,UA,U,C */+   370   370   370   370   300    /* AU,UA,U,G */+   300   300   300   300   300    /* AU,UA,U,U */+   370   370   370   370   370    /* AU,NS,E,E */+   370   370   370   370   370    /* AU,NS,E,A */+   370   370   370   370   370    /* AU,NS,E,C */+   370   370   370   370   370    /* AU,NS,E,G */+   370   370   370   370   370    /* AU,NS,E,U */+   370   370   370   370   370    /* AU,NS,A,E */+   370   370   370   370   370    /* AU,NS,A,A */+   370   370   370   370   370    /* AU,NS,A,C */+   260   260   260   260   260    /* AU,NS,A,G */+   370   370   370   370   370    /* AU,NS,A,U */+   370   370   370   370   370    /* AU,NS,C,E */+   370   370   370   370   370    /* AU,NS,C,A */+   370   370   370   370   370    /* AU,NS,C,C */+   370   370   370   370   370    /* AU,NS,C,G */+   370   370   370   370   370    /* AU,NS,C,U */+   370   260   370   260   370    /* AU,NS,G,E */+   370   260   370   260   370    /* AU,NS,G,A */+   370   260   370   260   370    /* AU,NS,G,C */+   260   260   260   260   260    /* AU,NS,G,G */+   370   260   370   260   370    /* AU,NS,G,U */+   370   370   370   370   300    /* AU,NS,U,E */+   370   370   370   370   300    /* AU,NS,U,A */+   370   370   370   370   300    /* AU,NS,U,C */+   370   370   370   370   300    /* AU,NS,U,G */+   300   300   300   300   300    /* AU,NS,U,U */+   300   300   300   300   300    /* UA,CG,E,E */+   300   300   300   300   300    /* UA,CG,E,A */+   300   300   300   300   300    /* UA,CG,E,C */+   300   300   300   300   300    /* UA,CG,E,G */+   300   300   300   300   300    /* UA,CG,E,U */+   300   300   300   190   300    /* UA,CG,A,E */+   300   300   300   190   300    /* UA,CG,A,A */+   300   300   300   190   300    /* UA,CG,A,C */+   190   190   190   190   190    /* UA,CG,A,G */+   300   300   300   190   300    /* UA,CG,A,U */+   300   300   300   300   300    /* UA,CG,C,E */+   300   300   300   300   300    /* UA,CG,C,A */+   300   300   300   300   300    /* UA,CG,C,C */+   300   300   300   300   300    /* UA,CG,C,G */+   300   300   300   300   300    /* UA,CG,C,U */+   300   190   300   190   300    /* UA,CG,G,E */+   190   190   190   190   190    /* UA,CG,G,A */+   300   190   300   190   300    /* UA,CG,G,C */+   190   190   190   190   190    /* UA,CG,G,G */+   300   190   300   190   300    /* UA,CG,G,U */+   300   300   300   300   220    /* UA,CG,U,E */+   300   300   300   300   220    /* UA,CG,U,A */+   300   300   300   300   220    /* UA,CG,U,C */+   300   300   300   300   220    /* UA,CG,U,G */+   220   220   220   220   220    /* UA,CG,U,U */+   300   300   300   300   300    /* UA,GC,E,E */+   300   300   300   300   300    /* UA,GC,E,A */+   300   300   300   300   300    /* UA,GC,E,C */+   300   300   300   300   300    /* UA,GC,E,G */+   300   300   300   300   300    /* UA,GC,E,U */+   300   300   300   190   300    /* UA,GC,A,E */+   300   300   300   190   300    /* UA,GC,A,A */+   300   300   300   190   300    /* UA,GC,A,C */+   190   190   190   190   190    /* UA,GC,A,G */+   300   300   300   190   300    /* UA,GC,A,U */+   300   300   300   300   300    /* UA,GC,C,E */+   300   300   300   300   300    /* UA,GC,C,A */+   300   300   300   300   300    /* UA,GC,C,C */+   300   300   300   300   300    /* UA,GC,C,G */+   300   300   300   300   300    /* UA,GC,C,U */+   300   190   300   190   300    /* UA,GC,G,E */+   300   190   300   190   300    /* UA,GC,G,A */+   300   190   300   190   300    /* UA,GC,G,C */+   190   190   190   190   190    /* UA,GC,G,G */+   300   190   300   190   300    /* UA,GC,G,U */+   300   300   300   300   220    /* UA,GC,U,E */+   300   300   300   300   220    /* UA,GC,U,A */+   300   300   300   300   220    /* UA,GC,U,C */+   300   300   300   300   220    /* UA,GC,U,G */+   220   220   220   220   220    /* UA,GC,U,U */+   370   370   370   370   370    /* UA,GU,E,E */+   370   370   370   370   370    /* UA,GU,E,A */+   370   370   370   370   370    /* UA,GU,E,C */+   370   370   370   370   370    /* UA,GU,E,G */+   370   370   370   370   370    /* UA,GU,E,U */+   370   370   370   260   370    /* UA,GU,A,E */+   370   370   370   260   370    /* UA,GU,A,A */+   370   370   370   260   370    /* UA,GU,A,C */+   260   260   260   260   260    /* UA,GU,A,G */+   370   370   370   260   370    /* UA,GU,A,U */+   370   370   370   370   370    /* UA,GU,C,E */+   370   370   370   370   370    /* UA,GU,C,A */+   370   370   370   370   370    /* UA,GU,C,C */+   370   370   370   370   370    /* UA,GU,C,G */+   370   370   370   370   370    /* UA,GU,C,U */+   370   260   370   260   370    /* UA,GU,G,E */+   370   260   370   260   370    /* UA,GU,G,A */+   370   260   370   260   370    /* UA,GU,G,C */+   260   260   260   260   260    /* UA,GU,G,G */+   370   260   370   260   370    /* UA,GU,G,U */+   370   370   370   370   300    /* UA,GU,U,E */+   370   370   370   370   300    /* UA,GU,U,A */+   370   370   370   370   300    /* UA,GU,U,C */+   370   370   370   370   300    /* UA,GU,U,G */+   300   300   300   300   300    /* UA,GU,U,U */+   370   370   370   370   370    /* UA,UG,E,E */+   370   370   370   370   370    /* UA,UG,E,A */+   370   370   370   370   370    /* UA,UG,E,C */+   370   370   370   370   370    /* UA,UG,E,G */+   370   370   370   370   370    /* UA,UG,E,U */+   370   370   370   260   370    /* UA,UG,A,E */+   370   370   370   260   370    /* UA,UG,A,A */+   370   370   370   260   370    /* UA,UG,A,C */+   260   260   260   260   260    /* UA,UG,A,G */+   370   370   370   260   370    /* UA,UG,A,U */+   370   370   370   370   370    /* UA,UG,C,E */+   370   370   370   370   370    /* UA,UG,C,A */+   370   370   370   370   370    /* UA,UG,C,C */+   370   370   370   370   370    /* UA,UG,C,G */+   370   370   370   370   370    /* UA,UG,C,U */+   370   260   370   260   370    /* UA,UG,G,E */+   260   260   260   260   260    /* UA,UG,G,A */+   370   260   370   260   370    /* UA,UG,G,C */+   260   260   260   260   260    /* UA,UG,G,G */+   370   260   370   260   370    /* UA,UG,G,U */+   370   370   370   370   300    /* UA,UG,U,E */+   370   370   370   370   300    /* UA,UG,U,A */+   370   370   370   370   300    /* UA,UG,U,C */+   370   370   370   370   300    /* UA,UG,U,G */+   300   300   300   300   300    /* UA,UG,U,U */+   370   370   370   370   370    /* UA,AU,E,E */+   370   370   370   370   370    /* UA,AU,E,A */+   370   370   370   370   370    /* UA,AU,E,C */+   370   370   370   370   370    /* UA,AU,E,G */+   370   370   370   370   370    /* UA,AU,E,U */+   370   370   370   260   370    /* UA,AU,A,E */+   370   370   370   260   370    /* UA,AU,A,A */+   370   370   370   260   370    /* UA,AU,A,C */+   260   260   260   260   260    /* UA,AU,A,G */+   370   370   370   260   370    /* UA,AU,A,U */+   370   370   370   370   370    /* UA,AU,C,E */+   370   370   370   370   370    /* UA,AU,C,A */+   370   370   370   370   370    /* UA,AU,C,C */+   370   370   370   370   370    /* UA,AU,C,G */+   370   370   370   370   370    /* UA,AU,C,U */+   370   260   370   260   370    /* UA,AU,G,E */+   370   260   370   260   370    /* UA,AU,G,A */+   370   260   370   260   370    /* UA,AU,G,C */+   260   260   260   260   260    /* UA,AU,G,G */+   370   260   370   260   370    /* UA,AU,G,U */+   370   370   370   370   300    /* UA,AU,U,E */+   370   370   370   370   300    /* UA,AU,U,A */+   370   370   370   370   300    /* UA,AU,U,C */+   370   370   370   370   300    /* UA,AU,U,G */+   300   300   300   300   300    /* UA,AU,U,U */+   370   370   370   370   370    /* UA,UA,E,E */+   370   370   370   370   370    /* UA,UA,E,A */+   370   370   370   370   370    /* UA,UA,E,C */+   370   370   370   370   370    /* UA,UA,E,G */+   370   370   370   370   370    /* UA,UA,E,U */+   370   370   370   260   370    /* UA,UA,A,E */+   370   370   370   260   370    /* UA,UA,A,A */+   370   370   370   260   370    /* UA,UA,A,C */+   260   260   260   260   260    /* UA,UA,A,G */+   370   370   370   260   370    /* UA,UA,A,U */+   370   370   370   370   370    /* UA,UA,C,E */+   370   370   370   370   370    /* UA,UA,C,A */+   370   370   370   370   370    /* UA,UA,C,C */+   370   370   370   370   370    /* UA,UA,C,G */+   370   370   370   370   370    /* UA,UA,C,U */+   370   260   370   260   370    /* UA,UA,G,E */+   260   260   260   260   260    /* UA,UA,G,A */+   370   260   370   260   370    /* UA,UA,G,C */+   260   260   260   260   260    /* UA,UA,G,G */+   370   260   370   260   370    /* UA,UA,G,U */+   370   370   370   370   300    /* UA,UA,U,E */+   370   370   370   370   300    /* UA,UA,U,A */+   370   370   370   370   300    /* UA,UA,U,C */+   370   370   370   370   300    /* UA,UA,U,G */+   300   300   300   300   300    /* UA,UA,U,U */+   370   370   370   370   370    /* UA,NS,E,E */+   370   370   370   370   370    /* UA,NS,E,A */+   370   370   370   370   370    /* UA,NS,E,C */+   370   370   370   370   370    /* UA,NS,E,G */+   370   370   370   370   370    /* UA,NS,E,U */+   370   370   370   260   370    /* UA,NS,A,E */+   370   370   370   260   370    /* UA,NS,A,A */+   370   370   370   260   370    /* UA,NS,A,C */+   260   260   260   260   260    /* UA,NS,A,G */+   370   370   370   260   370    /* UA,NS,A,U */+   370   370   370   370   370    /* UA,NS,C,E */+   370   370   370   370   370    /* UA,NS,C,A */+   370   370   370   370   370    /* UA,NS,C,C */+   370   370   370   370   370    /* UA,NS,C,G */+   370   370   370   370   370    /* UA,NS,C,U */+   370   260   370   260   370    /* UA,NS,G,E */+   370   260   370   260   370    /* UA,NS,G,A */+   370   260   370   260   370    /* UA,NS,G,C */+   260   260   260   260   260    /* UA,NS,G,G */+   370   260   370   260   370    /* UA,NS,G,U */+   370   370   370   370   300    /* UA,NS,U,E */+   370   370   370   370   300    /* UA,NS,U,A */+   370   370   370   370   300    /* UA,NS,U,C */+   370   370   370   370   300    /* UA,NS,U,G */+   300   300   300   300   300    /* UA,NS,U,U */+   300   300   300   300   300    /* NS,CG,E,E */+   300   300   300   300   300    /* NS,CG,E,A */+   300   300   300   300   300    /* NS,CG,E,C */+   300   300   300   300   300    /* NS,CG,E,G */+   300   300   300   300   300    /* NS,CG,E,U */+   300   300   300   300   300    /* NS,CG,A,E */+   300   300   300   300   300    /* NS,CG,A,A */+   300   300   300   300   300    /* NS,CG,A,C */+   190   190   190   190   190    /* NS,CG,A,G */+   300   300   300   300   300    /* NS,CG,A,U */+   300   300   300   300   300    /* NS,CG,C,E */+   300   300   300   300   300    /* NS,CG,C,A */+   300   300   300   300   300    /* NS,CG,C,C */+   300   300   300   300   300    /* NS,CG,C,G */+   300   300   300   300   300    /* NS,CG,C,U */+   300   190   300   190   300    /* NS,CG,G,E */+   190   190   190   190   190    /* NS,CG,G,A */+   300   190   300   190   300    /* NS,CG,G,C */+   190   190   190   190   190    /* NS,CG,G,G */+   300   190   300   190   300    /* NS,CG,G,U */+   300   300   300   300   220    /* NS,CG,U,E */+   300   300   300   300   220    /* NS,CG,U,A */+   300   300   300   300   220    /* NS,CG,U,C */+   300   300   300   300   220    /* NS,CG,U,G */+   220   220   220   220   220    /* NS,CG,U,U */+   300   300   300   300   300    /* NS,GC,E,E */+   300   300   300   300   300    /* NS,GC,E,A */+   300   300   300   300   300    /* NS,GC,E,C */+   300   300   300   300   300    /* NS,GC,E,G */+   300   300   300   300   300    /* NS,GC,E,U */+   300   300   300   300   300    /* NS,GC,A,E */+   300   300   300   300   300    /* NS,GC,A,A */+   300   300   300   300   300    /* NS,GC,A,C */+   190   190   190   190   190    /* NS,GC,A,G */+   300   300   300   300   300    /* NS,GC,A,U */+   300   300   300   300   300    /* NS,GC,C,E */+   300   300   300   300   300    /* NS,GC,C,A */+   300   300   300   300   300    /* NS,GC,C,C */+   300   300   300   300   300    /* NS,GC,C,G */+   300   300   300   300   300    /* NS,GC,C,U */+   300   190   300   190   300    /* NS,GC,G,E */+   300   190   300   190   300    /* NS,GC,G,A */+   300   190   300   190   300    /* NS,GC,G,C */+   190   190   190   190   190    /* NS,GC,G,G */+   300   190   300   190   300    /* NS,GC,G,U */+   300   300   300   300   220    /* NS,GC,U,E */+   300   300   300   300   220    /* NS,GC,U,A */+   300   300   300   300   220    /* NS,GC,U,C */+   300   300   300   300   220    /* NS,GC,U,G */+   220   220   220   220   220    /* NS,GC,U,U */+   370   370   370   370   370    /* NS,GU,E,E */+   370   370   370   370   370    /* NS,GU,E,A */+   370   370   370   370   370    /* NS,GU,E,C */+   370   370   370   370   370    /* NS,GU,E,G */+   370   370   370   370   370    /* NS,GU,E,U */+   370   370   370   370   370    /* NS,GU,A,E */+   370   370   370   370   370    /* NS,GU,A,A */+   370   370   370   370   370    /* NS,GU,A,C */+   260   260   260   260   260    /* NS,GU,A,G */+   370   370   370   370   370    /* NS,GU,A,U */+   370   370   370   370   370    /* NS,GU,C,E */+   370   370   370   370   370    /* NS,GU,C,A */+   370   370   370   370   370    /* NS,GU,C,C */+   370   370   370   370   370    /* NS,GU,C,G */+   370   370   370   370   370    /* NS,GU,C,U */+   370   260   370   260   370    /* NS,GU,G,E */+   370   260   370   260   370    /* NS,GU,G,A */+   370   260   370   260   370    /* NS,GU,G,C */+   260   260   260   260   260    /* NS,GU,G,G */+   370   260   370   260   370    /* NS,GU,G,U */+   370   370   370   370   300    /* NS,GU,U,E */+   370   370   370   370   300    /* NS,GU,U,A */+   370   370   370   370   300    /* NS,GU,U,C */+   370   370   370   370   300    /* NS,GU,U,G */+   300   300   300   300   300    /* NS,GU,U,U */+   370   370   370   370   370    /* NS,UG,E,E */+   370   370   370   370   370    /* NS,UG,E,A */+   370   370   370   370   370    /* NS,UG,E,C */+   370   370   370   370   370    /* NS,UG,E,G */+   370   370   370   370   370    /* NS,UG,E,U */+   370   370   370   370   370    /* NS,UG,A,E */+   370   370   370   370   370    /* NS,UG,A,A */+   370   370   370   370   370    /* NS,UG,A,C */+   260   260   260   260   260    /* NS,UG,A,G */+   370   370   370   370   370    /* NS,UG,A,U */+   370   370   370   370   370    /* NS,UG,C,E */+   370   370   370   370   370    /* NS,UG,C,A */+   370   370   370   370   370    /* NS,UG,C,C */+   370   370   370   370   370    /* NS,UG,C,G */+   370   370   370   370   370    /* NS,UG,C,U */+   370   260   370   260   370    /* NS,UG,G,E */+   260   260   260   260   260    /* NS,UG,G,A */+   370   260   370   260   370    /* NS,UG,G,C */+   260   260   260   260   260    /* NS,UG,G,G */+   370   260   370   260   370    /* NS,UG,G,U */+   370   370   370   370   300    /* NS,UG,U,E */+   370   370   370   370   300    /* NS,UG,U,A */+   370   370   370   370   300    /* NS,UG,U,C */+   370   370   370   370   300    /* NS,UG,U,G */+   300   300   300   300   300    /* NS,UG,U,U */+   370   370   370   370   370    /* NS,AU,E,E */+   370   370   370   370   370    /* NS,AU,E,A */+   370   370   370   370   370    /* NS,AU,E,C */+   370   370   370   370   370    /* NS,AU,E,G */+   370   370   370   370   370    /* NS,AU,E,U */+   370   370   370   370   370    /* NS,AU,A,E */+   370   370   370   370   370    /* NS,AU,A,A */+   370   370   370   370   370    /* NS,AU,A,C */+   260   260   260   260   260    /* NS,AU,A,G */+   370   370   370   370   370    /* NS,AU,A,U */+   370   370   370   370   370    /* NS,AU,C,E */+   370   370   370   370   370    /* NS,AU,C,A */+   370   370   370   370   370    /* NS,AU,C,C */+   370   370   370   370   370    /* NS,AU,C,G */+   370   370   370   370   370    /* NS,AU,C,U */+   370   260   370   260   370    /* NS,AU,G,E */+   370   260   370   260   370    /* NS,AU,G,A */+   370   260   370   260   370    /* NS,AU,G,C */+   260   260   260   260   260    /* NS,AU,G,G */+   370   260   370   260   370    /* NS,AU,G,U */+   370   370   370   370   300    /* NS,AU,U,E */+   370   370   370   370   300    /* NS,AU,U,A */+   370   370   370   370   300    /* NS,AU,U,C */+   370   370   370   370   300    /* NS,AU,U,G */+   300   300   300   300   300    /* NS,AU,U,U */+   370   370   370   370   370    /* NS,UA,E,E */+   370   370   370   370   370    /* NS,UA,E,A */+   370   370   370   370   370    /* NS,UA,E,C */+   370   370   370   370   370    /* NS,UA,E,G */+   370   370   370   370   370    /* NS,UA,E,U */+   370   370   370   370   370    /* NS,UA,A,E */+   370   370   370   370   370    /* NS,UA,A,A */+   370   370   370   370   370    /* NS,UA,A,C */+   260   260   260   260   260    /* NS,UA,A,G */+   370   370   370   370   370    /* NS,UA,A,U */+   370   370   370   370   370    /* NS,UA,C,E */+   370   370   370   370   370    /* NS,UA,C,A */+   370   370   370   370   370    /* NS,UA,C,C */+   370   370   370   370   370    /* NS,UA,C,G */+   370   370   370   370   370    /* NS,UA,C,U */+   370   260   370   260   370    /* NS,UA,G,E */+   260   260   260   260   260    /* NS,UA,G,A */+   370   260   370   260   370    /* NS,UA,G,C */+   260   260   260   260   260    /* NS,UA,G,G */+   370   260   370   260   370    /* NS,UA,G,U */+   370   370   370   370   300    /* NS,UA,U,E */+   370   370   370   370   300    /* NS,UA,U,A */+   370   370   370   370   300    /* NS,UA,U,C */+   370   370   370   370   300    /* NS,UA,U,G */+   300   300   300   300   300    /* NS,UA,U,U */+   370   370   370   370   370    /* NS,NS,E,E */+   370   370   370   370   370    /* NS,NS,E,A */+   370   370   370   370   370    /* NS,NS,E,C */+   370   370   370   370   370    /* NS,NS,E,G */+   370   370   370   370   370    /* NS,NS,E,U */+   370   370   370   370   370    /* NS,NS,A,E */+   370   370   370   370   370    /* NS,NS,A,A */+   370   370   370   370   370    /* NS,NS,A,C */+   260   260   260   260   260    /* NS,NS,A,G */+   370   370   370   370   370    /* NS,NS,A,U */+   370   370   370   370   370    /* NS,NS,C,E */+   370   370   370   370   370    /* NS,NS,C,A */+   370   370   370   370   370    /* NS,NS,C,C */+   370   370   370   370   370    /* NS,NS,C,G */+   370   370   370   370   370    /* NS,NS,C,U */+   370   260   370   260   370    /* NS,NS,G,E */+   370   260   370   260   370    /* NS,NS,G,A */+   370   260   370   260   370    /* NS,NS,G,C */+   260   260   260   260   260    /* NS,NS,G,G */+   370   260   370   260   370    /* NS,NS,G,U */+   370   370   370   370   300    /* NS,NS,U,E */+   370   370   370   370   300    /* NS,NS,U,A */+   370   370   370   370   300    /* NS,NS,U,C */+   370   370   370   370   300    /* NS,NS,U,G */+   300   300   300   300   300    /* NS,NS,U,U */++# int21_enthalpies+   350   350   350   350   350    /* CG,CG,E,E */+   350   350   350   350   350    /* CG,CG,E,A */+   350   350   350   350   350    /* CG,CG,E,C */+   350   350   350   350   350    /* CG,CG,E,G */+   350   350   350   350   350    /* CG,CG,E,U */+   350   350   350  -230   350    /* CG,CG,A,E */+   350   350   350  -230   350    /* CG,CG,A,A */+   350   350   350  -230   350    /* CG,CG,A,C */+  -230  -230  -230  -230  -230    /* CG,CG,A,G */+   350   350   350  -230   350    /* CG,CG,A,U */+   350   350   350   350   350    /* CG,CG,C,E */+   350   350   350   350   350    /* CG,CG,C,A */+   350   350   350   350   350    /* CG,CG,C,C */+   350   350   350   350   350    /* CG,CG,C,G */+   350   350   350   350   350    /* CG,CG,C,U */+   350  -230   350  -230   350    /* CG,CG,G,E */+  -230  -230  -230  -230  -230    /* CG,CG,G,A */+   350  -230   350  -230   350    /* CG,CG,G,C */+  -230  -230  -230  -230  -230    /* CG,CG,G,G */+   350  -230   350  -230   350    /* CG,CG,G,U */+   350   350   350   350  -670    /* CG,CG,U,E */+   350   350   350   350  -670    /* CG,CG,U,A */+   350   350   350   350  -670    /* CG,CG,U,C */+   350   350   350   350  -670    /* CG,CG,U,G */+  -670  -670  -670  -670  -670    /* CG,CG,U,U */+   780   640   780   350   350    /* CG,GC,E,E */+   350   350   350   350   350    /* CG,GC,E,A */+   780   350   780   350   350    /* CG,GC,E,C */+   350   350   350   350   350    /* CG,GC,E,G */+   640   640   350   350   350    /* CG,GC,E,U */+   350   350   350   250   350    /* CG,GC,A,E */+   350   260   350   250   350    /* CG,GC,A,A */+   350   350  -250  -230   350    /* CG,GC,A,C */+  -230  -230  -230  -230  -230    /* CG,GC,A,G */+   350   350   350  -230   350    /* CG,GC,A,U */+   780   640   780   350   350    /* CG,GC,C,E */+   350   160   350   350   350    /* CG,GC,C,A */+   780   350   780   350   350    /* CG,GC,C,C */+   350   350   350   350   350    /* CG,GC,C,G */+   640   640   350   350   350    /* CG,GC,C,U */+   350  -160   350  -230   350    /* CG,GC,G,E */+   350  -160   350  -410   350    /* CG,GC,G,A */+   350  -230   350  -230   350    /* CG,GC,G,C */+  -230  -310  -230  -230  -230    /* CG,GC,G,G */+   350  -230   350  -230   350    /* CG,GC,G,U */+   580   350   580   350  -580    /* CG,GC,U,E */+   350   350   350   350  -670    /* CG,GC,U,A */+   580   350   580   350  -580    /* CG,GC,U,C */+   350   350   350   350  -670    /* CG,GC,U,G */+  -670  -670  -690  -670  -700    /* CG,GC,U,U */+   850   850   850   850   850    /* CG,GU,E,E */+   850   850   850   850   850    /* CG,GU,E,A */+   850   850   850   850   850    /* CG,GU,E,C */+   850   850   850   850   850    /* CG,GU,E,G */+   850   850   850   850   850    /* CG,GU,E,U */+   850   850   850   280   850    /* CG,GU,A,E */+   850   850   850   280   850    /* CG,GU,A,A */+   850   850   850   280   850    /* CG,GU,A,C */+   280   280   280   280   280    /* CG,GU,A,G */+   850   850   850   280   850    /* CG,GU,A,U */+   850   850   850   850   850    /* CG,GU,C,E */+   850   850   850   850   850    /* CG,GU,C,A */+   850   850   850   850   850    /* CG,GU,C,C */+   850   850   850   850   850    /* CG,GU,C,G */+   850   850   850   850   850    /* CG,GU,C,U */+   850   280   850   280   850    /* CG,GU,G,E */+   850   280   850   280   850    /* CG,GU,G,A */+   850   280   850   280   850    /* CG,GU,G,C */+   280   280   280   280   280    /* CG,GU,G,G */+   850   280   850   280   850    /* CG,GU,G,U */+   850   850   850   850  -160    /* CG,GU,U,E */+   850   850   850   850  -160    /* CG,GU,U,A */+   850   850   850   850  -160    /* CG,GU,U,C */+   850   850   850   850  -160    /* CG,GU,U,G */+  -160  -160  -160  -160  -160    /* CG,GU,U,U */+   850   850   850   850   850    /* CG,UG,E,E */+   850   850   850   850   850    /* CG,UG,E,A */+   850   850   850   850   850    /* CG,UG,E,C */+   850   850   850   850   850    /* CG,UG,E,G */+   850   850   850   850   850    /* CG,UG,E,U */+   850   850   850   280   850    /* CG,UG,A,E */+   850   850   850   280   850    /* CG,UG,A,A */+   850   850   850   280   850    /* CG,UG,A,C */+   280   280   280   280   280    /* CG,UG,A,G */+   850   850   850   280   850    /* CG,UG,A,U */+   850   850   850   850   850    /* CG,UG,C,E */+   850   850   850   850   850    /* CG,UG,C,A */+   850   850   850   850   850    /* CG,UG,C,C */+   850   850   850   850   850    /* CG,UG,C,G */+   850   850   850   850   850    /* CG,UG,C,U */+   850   280   850   280   850    /* CG,UG,G,E */+   280   280   280   280   280    /* CG,UG,G,A */+   850   280   850   280   850    /* CG,UG,G,C */+   280   280   280   280   280    /* CG,UG,G,G */+   850   280   850   280   850    /* CG,UG,G,U */+   850   850   850   850  -160    /* CG,UG,U,E */+   850   850   850   850  -160    /* CG,UG,U,A */+   850   850   850   850  -160    /* CG,UG,U,C */+   850   850   850   850  -160    /* CG,UG,U,G */+  -160  -160  -160  -160  -160    /* CG,UG,U,U */+   850   850   850   850   850    /* CG,AU,E,E */+   850   850   850   850   850    /* CG,AU,E,A */+   850   850   850   850   850    /* CG,AU,E,C */+   850   850   850   850   850    /* CG,AU,E,G */+   850   850   850   850   850    /* CG,AU,E,U */+   850   850   850   280   850    /* CG,AU,A,E */+   850   850   850   280   850    /* CG,AU,A,A */+   850   850   850   280   850    /* CG,AU,A,C */+   280   280   280   280   280    /* CG,AU,A,G */+   850   850   850   280   850    /* CG,AU,A,U */+   850   850   850   850   850    /* CG,AU,C,E */+   850   850   850   850   850    /* CG,AU,C,A */+   850   850   850   850   850    /* CG,AU,C,C */+   850   850   850   850   850    /* CG,AU,C,G */+   850   850   850   850   850    /* CG,AU,C,U */+   850   280   850   280   850    /* CG,AU,G,E */+   850   280   850   280   850    /* CG,AU,G,A */+   850   280   850   280   850    /* CG,AU,G,C */+   280   280   280   280   280    /* CG,AU,G,G */+   850   280   850   280   850    /* CG,AU,G,U */+   850   850   850   850  -160    /* CG,AU,U,E */+   850   850   850   850  -160    /* CG,AU,U,A */+   850   850   850   850  -160    /* CG,AU,U,C */+   850   850   850   850  -160    /* CG,AU,U,G */+  -160  -160  -160  -160  -160    /* CG,AU,U,U */+   850   850   850   850   850    /* CG,UA,E,E */+   850   850   850   850   850    /* CG,UA,E,A */+   850   850   850   850   850    /* CG,UA,E,C */+   850   850   850   850   850    /* CG,UA,E,G */+   850   850   850   850   850    /* CG,UA,E,U */+   850   850   850   280   850    /* CG,UA,A,E */+   850   850   850   280   850    /* CG,UA,A,A */+   850   850   850   280   850    /* CG,UA,A,C */+   280   280   280   280   280    /* CG,UA,A,G */+   850   850   850   280   850    /* CG,UA,A,U */+   850   850   850   850   850    /* CG,UA,C,E */+   850   850   850   850   850    /* CG,UA,C,A */+   850   850   850   850   850    /* CG,UA,C,C */+   850   850   850   850   850    /* CG,UA,C,G */+   850   850   850   850   850    /* CG,UA,C,U */+   850   280   850   280   850    /* CG,UA,G,E */+   280   280   280   280   280    /* CG,UA,G,A */+   850   280   850   280   850    /* CG,UA,G,C */+   280   280   280   280   280    /* CG,UA,G,G */+   850   280   850   280   850    /* CG,UA,G,U */+   850   850   850   850  -160    /* CG,UA,U,E */+   850   850   850   850  -160    /* CG,UA,U,A */+   850   850   850   850  -160    /* CG,UA,U,C */+   850   850   850   850  -160    /* CG,UA,U,G */+  -160  -160  -160  -160  -160    /* CG,UA,U,U */+   850   850   850   850   850    /* CG,NS,E,E */+   850   850   850   850   850    /* CG,NS,E,A */+   850   850   850   850   850    /* CG,NS,E,C */+   850   850   850   850   850    /* CG,NS,E,G */+   850   850   850   850   850    /* CG,NS,E,U */+   850   850   850   280   850    /* CG,NS,A,E */+   850   850   850   280   850    /* CG,NS,A,A */+   850   850   850   280   850    /* CG,NS,A,C */+   280   280   280   280   280    /* CG,NS,A,G */+   850   850   850   280   850    /* CG,NS,A,U */+   850   850   850   850   850    /* CG,NS,C,E */+   850   850   850   850   850    /* CG,NS,C,A */+   850   850   850   850   850    /* CG,NS,C,C */+   850   850   850   850   850    /* CG,NS,C,G */+   850   850   850   850   850    /* CG,NS,C,U */+   850   280   850   280   850    /* CG,NS,G,E */+   850   280   850   280   850    /* CG,NS,G,A */+   850   280   850   280   850    /* CG,NS,G,C */+   280   280   280   280   280    /* CG,NS,G,G */+   850   280   850   280   850    /* CG,NS,G,U */+   850   850   850   850  -160    /* CG,NS,U,E */+   850   850   850   850  -160    /* CG,NS,U,A */+   850   850   850   850  -160    /* CG,NS,U,C */+   850   850   850   850  -160    /* CG,NS,U,G */+  -160  -160  -160  -160  -160    /* CG,NS,U,U */+   690   690   350   350   350    /* GC,CG,E,E */+   690   690   350   350   350    /* GC,CG,E,A */+   350   350   350   350   350    /* GC,CG,E,C */+   350   350   350   350   350    /* GC,CG,E,G */+   350   350   350   350   350    /* GC,CG,E,U */+   690   690   350   350   350    /* GC,CG,A,E */+   690   690   350   240   350    /* GC,CG,A,A */+   350   350   350   350   350    /* GC,CG,A,C */+  -230  -500  -230  -230  -230    /* GC,CG,A,G */+   350   350   350   350   350    /* GC,CG,A,U */+   350   350   350   350   350    /* GC,CG,C,E */+   350   350   350   350   350    /* GC,CG,C,A */+   350   350   350   350   350    /* GC,CG,C,C */+   350   350   350   350   350    /* GC,CG,C,G */+   350   350   130   350   350    /* GC,CG,C,U */+   350  -230   350  -230   350    /* GC,CG,G,E */+  -230  -230  -230  -230  -230    /* GC,CG,G,A */+   350  -230   350  -230   350    /* GC,CG,G,C */+  -230  -230  -230  -230  -230    /* GC,CG,G,G */+   350  -230   350  -230   350    /* GC,CG,G,U */+   350   350   350   350  -670    /* GC,CG,U,E */+   350   350   350   350  -670    /* GC,CG,U,A */+   350   350   350   350  -670    /* GC,CG,U,C */+   350   350   350   350  -670    /* GC,CG,U,G */+  -670  -670  -670  -670  -670    /* GC,CG,U,U */+   350   350   350   350   350    /* GC,GC,E,E */+   350   350   350   350   350    /* GC,GC,E,A */+   350   350   350   350   350    /* GC,GC,E,C */+   350   350   350   350   350    /* GC,GC,E,G */+   350   350   350   350   350    /* GC,GC,E,U */+   350   350   350   350   350    /* GC,GC,A,E */+   350   350   350   350   350    /* GC,GC,A,A */+   350   350   350   350   350    /* GC,GC,A,C */+  -230  -230  -230  -230  -230    /* GC,GC,A,G */+   350   350   350   350   350    /* GC,GC,A,U */+   350   350   350   350   350    /* GC,GC,C,E */+   350   350   350   350   350    /* GC,GC,C,A */+   350   350   350   350   350    /* GC,GC,C,C */+   350   350   350   350   350    /* GC,GC,C,G */+   350   350   350   350   350    /* GC,GC,C,U */+   350  -230   350  -230   350    /* GC,GC,G,E */+   350  -230   350  -230   350    /* GC,GC,G,A */+   350  -230   350  -230   350    /* GC,GC,G,C */+  -230  -230  -230  -230  -230    /* GC,GC,G,G */+   350  -230   350  -230   350    /* GC,GC,G,U */+   350   350   350   350  -670    /* GC,GC,U,E */+   350   350   350   350  -670    /* GC,GC,U,A */+   350   350   350   350  -670    /* GC,GC,U,C */+   350   350   350   350  -670    /* GC,GC,U,G */+  -670  -670  -670  -670  -670    /* GC,GC,U,U */+   850   850   850   850   850    /* GC,GU,E,E */+   850   850   850   850   850    /* GC,GU,E,A */+   850   850   850   850   850    /* GC,GU,E,C */+   850   850   850   850   850    /* GC,GU,E,G */+   850   850   850   850   850    /* GC,GU,E,U */+   850   850   850   850   850    /* GC,GU,A,E */+   850   850   850   850   850    /* GC,GU,A,A */+   850   850   850   850   850    /* GC,GU,A,C */+   280   280   280   280   280    /* GC,GU,A,G */+   850   850   850   850   850    /* GC,GU,A,U */+   850   850   850   850   850    /* GC,GU,C,E */+   850   850   850   850   850    /* GC,GU,C,A */+   850   850   850   850   850    /* GC,GU,C,C */+   850   850   850   850   850    /* GC,GU,C,G */+   850   850   850   850   850    /* GC,GU,C,U */+   850   280   850   280   850    /* GC,GU,G,E */+   850   280   850   280   850    /* GC,GU,G,A */+   850   280   850   280   850    /* GC,GU,G,C */+   280   280   280   280   280    /* GC,GU,G,G */+   850   280   850   280   850    /* GC,GU,G,U */+   850   850   850   850  -160    /* GC,GU,U,E */+   850   850   850   850  -160    /* GC,GU,U,A */+   850   850   850   850  -160    /* GC,GU,U,C */+   850   850   850   850  -160    /* GC,GU,U,G */+  -160  -160  -160  -160  -160    /* GC,GU,U,U */+   850   850   850   850   850    /* GC,UG,E,E */+   850   850   850   850   850    /* GC,UG,E,A */+   850   850   850   850   850    /* GC,UG,E,C */+   850   850   850   850   850    /* GC,UG,E,G */+   850   850   850   850   850    /* GC,UG,E,U */+   850   850   850   850   850    /* GC,UG,A,E */+   850   690   850   240   850    /* GC,UG,A,A */+   850   850   850   850   850    /* GC,UG,A,C */+   280  -500   280   280   280    /* GC,UG,A,G */+   850   850   850   850   850    /* GC,UG,A,U */+   850   850   850   850   850    /* GC,UG,C,E */+   850   850   850   850   850    /* GC,UG,C,A */+   850   850   850   850   850    /* GC,UG,C,C */+   850   850   850   850   850    /* GC,UG,C,G */+   850   850   130   850   850    /* GC,UG,C,U */+   850   280   850   280   850    /* GC,UG,G,E */+   280   280   280   280   280    /* GC,UG,G,A */+   850   280   850   280   850    /* GC,UG,G,C */+   280   280   280   280   280    /* GC,UG,G,G */+   850   280   850   280   850    /* GC,UG,G,U */+   850   850   850   850  -160    /* GC,UG,U,E */+   850   850   850   850  -160    /* GC,UG,U,A */+   850   850   850   850  -160    /* GC,UG,U,C */+   850   850   850   850  -160    /* GC,UG,U,G */+  -160  -160  -160  -160  -160    /* GC,UG,U,U */+   850   850   850   850   850    /* GC,AU,E,E */+   850   850   850   850   850    /* GC,AU,E,A */+   850   850   850   850   850    /* GC,AU,E,C */+   850   850   850   850   850    /* GC,AU,E,G */+   850   850   850   850   850    /* GC,AU,E,U */+   850   850   850   850   850    /* GC,AU,A,E */+   850   850   850   850   850    /* GC,AU,A,A */+   850   850   850   850   850    /* GC,AU,A,C */+   280   280   280   280   280    /* GC,AU,A,G */+   850   850   850   850   850    /* GC,AU,A,U */+   850   850   850   850   850    /* GC,AU,C,E */+   850   850   850   850   850    /* GC,AU,C,A */+   850   850   850   850   850    /* GC,AU,C,C */+   850   850   850   850   850    /* GC,AU,C,G */+   850   850   850   850   850    /* GC,AU,C,U */+   850   280   850   280   850    /* GC,AU,G,E */+   850   280   850   280   850    /* GC,AU,G,A */+   850   280   850   280   850    /* GC,AU,G,C */+   280   280   280   280   280    /* GC,AU,G,G */+   850   280   850   280   850    /* GC,AU,G,U */+   850   850   850   850  -160    /* GC,AU,U,E */+   850   850   850   850  -160    /* GC,AU,U,A */+   850   850   850   850  -160    /* GC,AU,U,C */+   850   850   850   850  -160    /* GC,AU,U,G */+  -160  -160  -160  -160  -160    /* GC,AU,U,U */+   850   850   850   850   850    /* GC,UA,E,E */+   850   850   850   850   850    /* GC,UA,E,A */+   850   850   850   850   850    /* GC,UA,E,C */+   850   850   850   850   850    /* GC,UA,E,G */+   850   850   850   850   850    /* GC,UA,E,U */+   850   850   850   850   850    /* GC,UA,A,E */+   850   850   850   850   850    /* GC,UA,A,A */+   850   850   850   850   850    /* GC,UA,A,C */+   280   280   280   280   280    /* GC,UA,A,G */+   850   850   850   850   850    /* GC,UA,A,U */+   850   850   850   850   850    /* GC,UA,C,E */+   850   850   850   850   850    /* GC,UA,C,A */+   850   850   850   850   850    /* GC,UA,C,C */+   850   850   850   850   850    /* GC,UA,C,G */+   850   850   850   850   850    /* GC,UA,C,U */+   850   280   850   280   850    /* GC,UA,G,E */+   280   280   280   280   280    /* GC,UA,G,A */+   850   280   850   280   850    /* GC,UA,G,C */+   280   280   280   280   280    /* GC,UA,G,G */+   850   280   850   280   850    /* GC,UA,G,U */+   850   850   850   850  -160    /* GC,UA,U,E */+   850   850   850   850  -160    /* GC,UA,U,A */+   850   850   850   850  -160    /* GC,UA,U,C */+   850   850   850   850  -160    /* GC,UA,U,G */+  -160  -160  -160  -160  -160    /* GC,UA,U,U */+   850   850   850   850   850    /* GC,NS,E,E */+   850   850   850   850   850    /* GC,NS,E,A */+   850   850   850   850   850    /* GC,NS,E,C */+   850   850   850   850   850    /* GC,NS,E,G */+   850   850   850   850   850    /* GC,NS,E,U */+   850   850   850   850   850    /* GC,NS,A,E */+   850   850   850   850   850    /* GC,NS,A,A */+   850   850   850   850   850    /* GC,NS,A,C */+   280   280   280   280   280    /* GC,NS,A,G */+   850   850   850   850   850    /* GC,NS,A,U */+   850   850   850   850   850    /* GC,NS,C,E */+   850   850   850   850   850    /* GC,NS,C,A */+   850   850   850   850   850    /* GC,NS,C,C */+   850   850   850   850   850    /* GC,NS,C,G */+   850   850   850   850   850    /* GC,NS,C,U */+   850   280   850   280   850    /* GC,NS,G,E */+   850   280   850   280   850    /* GC,NS,G,A */+   850   280   850   280   850    /* GC,NS,G,C */+   280   280   280   280   280    /* GC,NS,G,G */+   850   280   850   280   850    /* GC,NS,G,U */+   850   850   850   850  -160    /* GC,NS,U,E */+   850   850   850   850  -160    /* GC,NS,U,A */+   850   850   850   850  -160    /* GC,NS,U,C */+   850   850   850   850  -160    /* GC,NS,U,G */+  -160  -160  -160  -160  -160    /* GC,NS,U,U */+   850   850   850   850   850    /* GU,CG,E,E */+   850   850   850   850   850    /* GU,CG,E,A */+   850   850   850   850   850    /* GU,CG,E,C */+   850   850   850   850   850    /* GU,CG,E,G */+   850   850   850   850   850    /* GU,CG,E,U */+   850   850   850   850   850    /* GU,CG,A,E */+   850   690   850   240   850    /* GU,CG,A,A */+   850   850   850   850   850    /* GU,CG,A,C */+   280  -500   280   280   280    /* GU,CG,A,G */+   850   850   850   850   850    /* GU,CG,A,U */+   850   850   850   850   850    /* GU,CG,C,E */+   850   850   850   850   850    /* GU,CG,C,A */+   850   850   850   850   850    /* GU,CG,C,C */+   850   850   850   850   850    /* GU,CG,C,G */+   850   850   130   850   850    /* GU,CG,C,U */+   850   280   850   280   850    /* GU,CG,G,E */+   280   280   280   280   280    /* GU,CG,G,A */+   850   280   850   280   850    /* GU,CG,G,C */+   280   280   280   280   280    /* GU,CG,G,G */+   850   280   850   280   850    /* GU,CG,G,U */+   850   850   850   850  -160    /* GU,CG,U,E */+   850   850   850   850  -160    /* GU,CG,U,A */+   850   850   850   850  -160    /* GU,CG,U,C */+   850   850   850   850  -160    /* GU,CG,U,G */+  -160  -160  -160  -160  -160    /* GU,CG,U,U */+   850   850   850   850   850    /* GU,GC,E,E */+   850   850   850   850   850    /* GU,GC,E,A */+   850   850   850   850   850    /* GU,GC,E,C */+   850   850   850   850   850    /* GU,GC,E,G */+   850   850   850   850   850    /* GU,GC,E,U */+   850   850   850   850   850    /* GU,GC,A,E */+   850   850   850   850   850    /* GU,GC,A,A */+   850   850   850   850   850    /* GU,GC,A,C */+   280   280   280   280   280    /* GU,GC,A,G */+   850   850   850   850   850    /* GU,GC,A,U */+   850   850   850   850   850    /* GU,GC,C,E */+   850   850   850   850   850    /* GU,GC,C,A */+   850   850   850   850   850    /* GU,GC,C,C */+   850   850   850   850   850    /* GU,GC,C,G */+   850   850   850   850   850    /* GU,GC,C,U */+   850   280   850   280   850    /* GU,GC,G,E */+   850   280   850   280   850    /* GU,GC,G,A */+   850   280   850   280   850    /* GU,GC,G,C */+   280   280   280   280   280    /* GU,GC,G,G */+   850   280   850   280   850    /* GU,GC,G,U */+   850   850   850   850  -160    /* GU,GC,U,E */+   850   850   850   850  -160    /* GU,GC,U,A */+   850   850   850   850  -160    /* GU,GC,U,C */+   850   850   850   850  -160    /* GU,GC,U,G */+  -160  -160  -160  -160  -160    /* GU,GC,U,U */+  1350  1350  1350  1350  1350    /* GU,GU,E,E */+  1350  1350  1350  1350  1350    /* GU,GU,E,A */+  1350  1350  1350  1350  1350    /* GU,GU,E,C */+  1350  1350  1350  1350  1350    /* GU,GU,E,G */+  1350  1350  1350  1350  1350    /* GU,GU,E,U */+  1350  1350  1350  1350  1350    /* GU,GU,A,E */+  1350  1350  1350  1350  1350    /* GU,GU,A,A */+  1350  1350  1350  1350  1350    /* GU,GU,A,C */+   780   780   780   780   780    /* GU,GU,A,G */+  1350  1350  1350  1350  1350    /* GU,GU,A,U */+  1350  1350  1350  1350  1350    /* GU,GU,C,E */+  1350  1350  1350  1350  1350    /* GU,GU,C,A */+  1350  1350  1350  1350  1350    /* GU,GU,C,C */+  1350  1350  1350  1350  1350    /* GU,GU,C,G */+  1350  1350  1350  1350  1350    /* GU,GU,C,U */+  1350   780  1350   780  1350    /* GU,GU,G,E */+  1350   780  1350   780  1350    /* GU,GU,G,A */+  1350   780  1350   780  1350    /* GU,GU,G,C */+   780   780   780   780   780    /* GU,GU,G,G */+  1350   780  1350   780  1350    /* GU,GU,G,U */+  1350  1350  1350  1350   340    /* GU,GU,U,E */+  1350  1350  1350  1350   340    /* GU,GU,U,A */+  1350  1350  1350  1350   340    /* GU,GU,U,C */+  1350  1350  1350  1350   340    /* GU,GU,U,G */+   340   340   340   340   340    /* GU,GU,U,U */+  1350  1350  1350  1350  1350    /* GU,UG,E,E */+  1350  1350  1350  1350  1350    /* GU,UG,E,A */+  1350  1350  1350  1350  1350    /* GU,UG,E,C */+  1350  1350  1350  1350  1350    /* GU,UG,E,G */+  1350  1350  1350  1350  1350    /* GU,UG,E,U */+  1350  1350  1350  1350  1350    /* GU,UG,A,E */+  1350   690  1350   240  1350    /* GU,UG,A,A */+  1350  1350  1350  1350  1350    /* GU,UG,A,C */+   780  -500   780   780   780    /* GU,UG,A,G */+  1350  1350  1350  1350  1350    /* GU,UG,A,U */+  1350  1350  1350  1350  1350    /* GU,UG,C,E */+  1350  1350  1350  1350  1350    /* GU,UG,C,A */+  1350  1350  1350  1350  1350    /* GU,UG,C,C */+  1350  1350  1350  1350  1350    /* GU,UG,C,G */+  1350  1350   130  1350  1350    /* GU,UG,C,U */+  1350   780  1350   780  1350    /* GU,UG,G,E */+   780   780   780   780   780    /* GU,UG,G,A */+  1350   780  1350   780  1350    /* GU,UG,G,C */+   780   780   780   780   780    /* GU,UG,G,G */+  1350   780  1350   780  1350    /* GU,UG,G,U */+  1350  1350  1350  1350   340    /* GU,UG,U,E */+  1350  1350  1350  1350   340    /* GU,UG,U,A */+  1350  1350  1350  1350   340    /* GU,UG,U,C */+  1350  1350  1350  1350   340    /* GU,UG,U,G */+   340   340   340   340   340    /* GU,UG,U,U */+  1350  1350  1350  1350  1350    /* GU,AU,E,E */+  1350  1350  1350  1350  1350    /* GU,AU,E,A */+  1350  1350  1350  1350  1350    /* GU,AU,E,C */+  1350  1350  1350  1350  1350    /* GU,AU,E,G */+  1350  1350  1350  1350  1350    /* GU,AU,E,U */+  1350  1350  1350  1350  1350    /* GU,AU,A,E */+  1350  1350  1350  1350  1350    /* GU,AU,A,A */+  1350  1350  1350  1350  1350    /* GU,AU,A,C */+   780   780   780   780   780    /* GU,AU,A,G */+  1350  1350  1350  1350  1350    /* GU,AU,A,U */+  1350  1350  1350  1350  1350    /* GU,AU,C,E */+  1350  1350  1350  1350  1350    /* GU,AU,C,A */+  1350  1350  1350  1350  1350    /* GU,AU,C,C */+  1350  1350  1350  1350  1350    /* GU,AU,C,G */+  1350  1350  1350  1350  1350    /* GU,AU,C,U */+  1350   780  1350   780  1350    /* GU,AU,G,E */+  1350   780  1350   780  1350    /* GU,AU,G,A */+  1350   780  1350   780  1350    /* GU,AU,G,C */+   780   780   780   780   780    /* GU,AU,G,G */+  1350   780  1350   780  1350    /* GU,AU,G,U */+  1350  1350  1350  1350   340    /* GU,AU,U,E */+  1350  1350  1350  1350   340    /* GU,AU,U,A */+  1350  1350  1350  1350   340    /* GU,AU,U,C */+  1350  1350  1350  1350   340    /* GU,AU,U,G */+   340   340   340   340   340    /* GU,AU,U,U */+  1350  1350  1350  1350  1350    /* GU,UA,E,E */+  1350  1350  1350  1350  1350    /* GU,UA,E,A */+  1350  1350  1350  1350  1350    /* GU,UA,E,C */+  1350  1350  1350  1350  1350    /* GU,UA,E,G */+  1350  1350  1350  1350  1350    /* GU,UA,E,U */+  1350  1350  1350  1350  1350    /* GU,UA,A,E */+  1350  1350  1350  1350  1350    /* GU,UA,A,A */+  1350  1350  1350  1350  1350    /* GU,UA,A,C */+   780   780   780   780   780    /* GU,UA,A,G */+  1350  1350  1350  1350  1350    /* GU,UA,A,U */+  1350  1350  1350  1350  1350    /* GU,UA,C,E */+  1350  1350  1350  1350  1350    /* GU,UA,C,A */+  1350  1350  1350  1350  1350    /* GU,UA,C,C */+  1350  1350  1350  1350  1350    /* GU,UA,C,G */+  1350  1350  1350  1350  1350    /* GU,UA,C,U */+  1350   780  1350   780  1350    /* GU,UA,G,E */+   780   780   780   780   780    /* GU,UA,G,A */+  1350   780  1350   780  1350    /* GU,UA,G,C */+   780   780   780   780   780    /* GU,UA,G,G */+  1350   780  1350   780  1350    /* GU,UA,G,U */+  1350  1350  1350  1350   340    /* GU,UA,U,E */+  1350  1350  1350  1350   340    /* GU,UA,U,A */+  1350  1350  1350  1350   340    /* GU,UA,U,C */+  1350  1350  1350  1350   340    /* GU,UA,U,G */+   340   340   340   340   340    /* GU,UA,U,U */+  1350  1350  1350  1350  1350    /* GU,NS,E,E */+  1350  1350  1350  1350  1350    /* GU,NS,E,A */+  1350  1350  1350  1350  1350    /* GU,NS,E,C */+  1350  1350  1350  1350  1350    /* GU,NS,E,G */+  1350  1350  1350  1350  1350    /* GU,NS,E,U */+  1350  1350  1350  1350  1350    /* GU,NS,A,E */+  1350  1350  1350  1350  1350    /* GU,NS,A,A */+  1350  1350  1350  1350  1350    /* GU,NS,A,C */+   780   780   780   780   780    /* GU,NS,A,G */+  1350  1350  1350  1350  1350    /* GU,NS,A,U */+  1350  1350  1350  1350  1350    /* GU,NS,C,E */+  1350  1350  1350  1350  1350    /* GU,NS,C,A */+  1350  1350  1350  1350  1350    /* GU,NS,C,C */+  1350  1350  1350  1350  1350    /* GU,NS,C,G */+  1350  1350  1350  1350  1350    /* GU,NS,C,U */+  1350   780  1350   780  1350    /* GU,NS,G,E */+  1350   780  1350   780  1350    /* GU,NS,G,A */+  1350   780  1350   780  1350    /* GU,NS,G,C */+   780   780   780   780   780    /* GU,NS,G,G */+  1350   780  1350   780  1350    /* GU,NS,G,U */+  1350  1350  1350  1350   340    /* GU,NS,U,E */+  1350  1350  1350  1350   340    /* GU,NS,U,A */+  1350  1350  1350  1350   340    /* GU,NS,U,C */+  1350  1350  1350  1350   340    /* GU,NS,U,G */+   340   340   340   340   340    /* GU,NS,U,U */+   850   850   850   850   850    /* UG,CG,E,E */+   850   850   850   850   850    /* UG,CG,E,A */+   850   850   850   850   850    /* UG,CG,E,C */+   850   850   850   850   850    /* UG,CG,E,G */+   850   850   850   850   850    /* UG,CG,E,U */+   850   850   850   280   850    /* UG,CG,A,E */+   850   850   850   280   850    /* UG,CG,A,A */+   850   850   850   280   850    /* UG,CG,A,C */+   280   280   280   280   280    /* UG,CG,A,G */+   850   850   850   280   850    /* UG,CG,A,U */+   850   850   850   850   850    /* UG,CG,C,E */+   850   850   850   850   850    /* UG,CG,C,A */+   850   850   850   850   850    /* UG,CG,C,C */+   850   850   850   850   850    /* UG,CG,C,G */+   850   850   850   850   850    /* UG,CG,C,U */+   850   280   850   280   850    /* UG,CG,G,E */+   280   280   280   280   280    /* UG,CG,G,A */+   850   280   850   280   850    /* UG,CG,G,C */+   280   280   280   280   280    /* UG,CG,G,G */+   850   280   850   280   850    /* UG,CG,G,U */+   850   850   850   850  -160    /* UG,CG,U,E */+   850   850   850   850  -160    /* UG,CG,U,A */+   850   850   850   850  -160    /* UG,CG,U,C */+   850   850   850   850  -160    /* UG,CG,U,G */+  -160  -160  -160  -160  -160    /* UG,CG,U,U */+   850   850   850   850   850    /* UG,GC,E,E */+   850   850   850   850   850    /* UG,GC,E,A */+   850   850   850   850   850    /* UG,GC,E,C */+   850   850   850   850   850    /* UG,GC,E,G */+   850   850   850   850   850    /* UG,GC,E,U */+   850   850   850   280   850    /* UG,GC,A,E */+   850   850   850   280   850    /* UG,GC,A,A */+   850   850   850   280   850    /* UG,GC,A,C */+   280   280   280   280   280    /* UG,GC,A,G */+   850   850   850   280   850    /* UG,GC,A,U */+   850   850   850   850   850    /* UG,GC,C,E */+   850   850   850   850   850    /* UG,GC,C,A */+   850   850   850   850   850    /* UG,GC,C,C */+   850   850   850   850   850    /* UG,GC,C,G */+   850   850   850   850   850    /* UG,GC,C,U */+   850   280   850   280   850    /* UG,GC,G,E */+   850   280   850   280   850    /* UG,GC,G,A */+   850   280   850   280   850    /* UG,GC,G,C */+   280   280   280   280   280    /* UG,GC,G,G */+   850   280   850   280   850    /* UG,GC,G,U */+   850   850   850   850  -160    /* UG,GC,U,E */+   850   850   850   850  -160    /* UG,GC,U,A */+   850   850   850   850  -160    /* UG,GC,U,C */+   850   850   850   850  -160    /* UG,GC,U,G */+  -160  -160  -160  -160  -160    /* UG,GC,U,U */+  1350  1350  1350  1350  1350    /* UG,GU,E,E */+  1350  1350  1350  1350  1350    /* UG,GU,E,A */+  1350  1350  1350  1350  1350    /* UG,GU,E,C */+  1350  1350  1350  1350  1350    /* UG,GU,E,G */+  1350  1350  1350  1350  1350    /* UG,GU,E,U */+  1350  1350  1350   780  1350    /* UG,GU,A,E */+  1350  1350  1350   780  1350    /* UG,GU,A,A */+  1350  1350  1350   780  1350    /* UG,GU,A,C */+   780   780   780   780   780    /* UG,GU,A,G */+  1350  1350  1350   780  1350    /* UG,GU,A,U */+  1350  1350  1350  1350  1350    /* UG,GU,C,E */+  1350  1350  1350  1350  1350    /* UG,GU,C,A */+  1350  1350  1350  1350  1350    /* UG,GU,C,C */+  1350  1350  1350  1350  1350    /* UG,GU,C,G */+  1350  1350  1350  1350  1350    /* UG,GU,C,U */+  1350   780  1350   780  1350    /* UG,GU,G,E */+  1350   780  1350   780  1350    /* UG,GU,G,A */+  1350   780  1350   780  1350    /* UG,GU,G,C */+   780   780   780   780   780    /* UG,GU,G,G */+  1350   780  1350   780  1350    /* UG,GU,G,U */+  1350  1350  1350  1350   340    /* UG,GU,U,E */+  1350  1350  1350  1350   340    /* UG,GU,U,A */+  1350  1350  1350  1350   340    /* UG,GU,U,C */+  1350  1350  1350  1350   340    /* UG,GU,U,G */+   340   340   340   340   340    /* UG,GU,U,U */+  1350  1350  1350  1350  1350    /* UG,UG,E,E */+  1350  1350  1350  1350  1350    /* UG,UG,E,A */+  1350  1350  1350  1350  1350    /* UG,UG,E,C */+  1350  1350  1350  1350  1350    /* UG,UG,E,G */+  1350  1350  1350  1350  1350    /* UG,UG,E,U */+  1350  1350  1350   780  1350    /* UG,UG,A,E */+  1350  1350  1350   780  1350    /* UG,UG,A,A */+  1350  1350  1350   780  1350    /* UG,UG,A,C */+   780   780   780   780   780    /* UG,UG,A,G */+  1350  1350  1350   780  1350    /* UG,UG,A,U */+  1350  1350  1350  1350  1350    /* UG,UG,C,E */+  1350  1350  1350  1350  1350    /* UG,UG,C,A */+  1350  1350  1350  1350  1350    /* UG,UG,C,C */+  1350  1350  1350  1350  1350    /* UG,UG,C,G */+  1350  1350  1350  1350  1350    /* UG,UG,C,U */+  1350   780  1350   780  1350    /* UG,UG,G,E */+   780   780   780   780   780    /* UG,UG,G,A */+  1350   780  1350   780  1350    /* UG,UG,G,C */+   780   780   780   780   780    /* UG,UG,G,G */+  1350   780  1350   780  1350    /* UG,UG,G,U */+  1350  1350  1350  1350   340    /* UG,UG,U,E */+  1350  1350  1350  1350   340    /* UG,UG,U,A */+  1350  1350  1350  1350   340    /* UG,UG,U,C */+  1350  1350  1350  1350   340    /* UG,UG,U,G */+   340   340   340   340   340    /* UG,UG,U,U */+  1350  1350  1350  1350  1350    /* UG,AU,E,E */+  1350  1350  1350  1350  1350    /* UG,AU,E,A */+  1350  1350  1350  1350  1350    /* UG,AU,E,C */+  1350  1350  1350  1350  1350    /* UG,AU,E,G */+  1350  1350  1350  1350  1350    /* UG,AU,E,U */+  1350  1350  1350   780  1350    /* UG,AU,A,E */+  1350  1350  1350   780  1350    /* UG,AU,A,A */+  1350  1350  1350   780  1350    /* UG,AU,A,C */+   780   780   780   780   780    /* UG,AU,A,G */+  1350  1350  1350   780  1350    /* UG,AU,A,U */+  1350  1350  1350  1350  1350    /* UG,AU,C,E */+  1350  1350  1350  1350  1350    /* UG,AU,C,A */+  1350  1350  1350  1350  1350    /* UG,AU,C,C */+  1350  1350  1350  1350  1350    /* UG,AU,C,G */+  1350  1350  1350  1350  1350    /* UG,AU,C,U */+  1350   780  1350   780  1350    /* UG,AU,G,E */+  1350   780  1350   780  1350    /* UG,AU,G,A */+  1350   780  1350   780  1350    /* UG,AU,G,C */+   780   780   780   780   780    /* UG,AU,G,G */+  1350   780  1350   780  1350    /* UG,AU,G,U */+  1350  1350  1350  1350   340    /* UG,AU,U,E */+  1350  1350  1350  1350   340    /* UG,AU,U,A */+  1350  1350  1350  1350   340    /* UG,AU,U,C */+  1350  1350  1350  1350   340    /* UG,AU,U,G */+   340   340   340   340   340    /* UG,AU,U,U */+  1350  1350  1350  1350  1350    /* UG,UA,E,E */+  1350  1350  1350  1350  1350    /* UG,UA,E,A */+  1350  1350  1350  1350  1350    /* UG,UA,E,C */+  1350  1350  1350  1350  1350    /* UG,UA,E,G */+  1350  1350  1350  1350  1350    /* UG,UA,E,U */+  1350  1350  1350   780  1350    /* UG,UA,A,E */+  1350  1350  1350   780  1350    /* UG,UA,A,A */+  1350  1350  1350   780  1350    /* UG,UA,A,C */+   780   780   780   780   780    /* UG,UA,A,G */+  1350  1350  1350   780  1350    /* UG,UA,A,U */+  1350  1350  1350  1350  1350    /* UG,UA,C,E */+  1350  1350  1350  1350  1350    /* UG,UA,C,A */+  1350  1350  1350  1350  1350    /* UG,UA,C,C */+  1350  1350  1350  1350  1350    /* UG,UA,C,G */+  1350  1350  1350  1350  1350    /* UG,UA,C,U */+  1350   780  1350   780  1350    /* UG,UA,G,E */+   780   780   780   780   780    /* UG,UA,G,A */+  1350   780  1350   780  1350    /* UG,UA,G,C */+   780   780   780   780   780    /* UG,UA,G,G */+  1350   780  1350   780  1350    /* UG,UA,G,U */+  1350  1350  1350  1350   340    /* UG,UA,U,E */+  1350  1350  1350  1350   340    /* UG,UA,U,A */+  1350  1350  1350  1350   340    /* UG,UA,U,C */+  1350  1350  1350  1350   340    /* UG,UA,U,G */+   340   340   340   340   340    /* UG,UA,U,U */+  1350  1350  1350  1350  1350    /* UG,NS,E,E */+  1350  1350  1350  1350  1350    /* UG,NS,E,A */+  1350  1350  1350  1350  1350    /* UG,NS,E,C */+  1350  1350  1350  1350  1350    /* UG,NS,E,G */+  1350  1350  1350  1350  1350    /* UG,NS,E,U */+  1350  1350  1350   780  1350    /* UG,NS,A,E */+  1350  1350  1350   780  1350    /* UG,NS,A,A */+  1350  1350  1350   780  1350    /* UG,NS,A,C */+   780   780   780   780   780    /* UG,NS,A,G */+  1350  1350  1350   780  1350    /* UG,NS,A,U */+  1350  1350  1350  1350  1350    /* UG,NS,C,E */+  1350  1350  1350  1350  1350    /* UG,NS,C,A */+  1350  1350  1350  1350  1350    /* UG,NS,C,C */+  1350  1350  1350  1350  1350    /* UG,NS,C,G */+  1350  1350  1350  1350  1350    /* UG,NS,C,U */+  1350   780  1350   780  1350    /* UG,NS,G,E */+  1350   780  1350   780  1350    /* UG,NS,G,A */+  1350   780  1350   780  1350    /* UG,NS,G,C */+   780   780   780   780   780    /* UG,NS,G,G */+  1350   780  1350   780  1350    /* UG,NS,G,U */+  1350  1350  1350  1350   340    /* UG,NS,U,E */+  1350  1350  1350  1350   340    /* UG,NS,U,A */+  1350  1350  1350  1350   340    /* UG,NS,U,C */+  1350  1350  1350  1350   340    /* UG,NS,U,G */+   340   340   340   340   340    /* UG,NS,U,U */+   850   850   850   850   850    /* AU,CG,E,E */+   850   850   850   850   850    /* AU,CG,E,A */+   850   850   850   850   850    /* AU,CG,E,C */+   850   850   850   850   850    /* AU,CG,E,G */+   850   850   850   850   850    /* AU,CG,E,U */+   850   850   850   850   850    /* AU,CG,A,E */+   850   850   850   850   850    /* AU,CG,A,A */+   850   850   850   850   850    /* AU,CG,A,C */+   280   280   280   280   280    /* AU,CG,A,G */+   850   850   850   850   850    /* AU,CG,A,U */+   850   850   850   850   850    /* AU,CG,C,E */+   850   850   850   850   850    /* AU,CG,C,A */+   850   850   850   850   850    /* AU,CG,C,C */+   850   850   850   850   850    /* AU,CG,C,G */+   850   850   850   850   850    /* AU,CG,C,U */+   850   280   850   280   850    /* AU,CG,G,E */+   280   280   280   280   280    /* AU,CG,G,A */+   850   280   850   280   850    /* AU,CG,G,C */+   280   280   280   280   280    /* AU,CG,G,G */+   850   280   850   280   850    /* AU,CG,G,U */+   850   850   850   850  -160    /* AU,CG,U,E */+   850   850   850   850  -160    /* AU,CG,U,A */+   850   850   850   850  -160    /* AU,CG,U,C */+   850   850   850   850  -160    /* AU,CG,U,G */+  -160  -160  -160  -160  -160    /* AU,CG,U,U */+   850   850   850   850   850    /* AU,GC,E,E */+   850   850   850   850   850    /* AU,GC,E,A */+   850   850   850   850   850    /* AU,GC,E,C */+   850   850   850   850   850    /* AU,GC,E,G */+   850   850   850   850   850    /* AU,GC,E,U */+   850   850   850   850   850    /* AU,GC,A,E */+   850   850   850   850   850    /* AU,GC,A,A */+   850   850   850   850   850    /* AU,GC,A,C */+   280   280   280   280   280    /* AU,GC,A,G */+   850   850   850   850   850    /* AU,GC,A,U */+   850   850   850   850   850    /* AU,GC,C,E */+   850   850   850   850   850    /* AU,GC,C,A */+   850   850   850   850   850    /* AU,GC,C,C */+   850   850   850   850   850    /* AU,GC,C,G */+   850   850   850   850   850    /* AU,GC,C,U */+   850   280   850   280   850    /* AU,GC,G,E */+   850   280   850   280   850    /* AU,GC,G,A */+   850   280   850   280   850    /* AU,GC,G,C */+   280   280   280   280   280    /* AU,GC,G,G */+   850   280   850   280   850    /* AU,GC,G,U */+   850   850   850   850  -160    /* AU,GC,U,E */+   850   850   850   850  -160    /* AU,GC,U,A */+   850   850   850   850  -160    /* AU,GC,U,C */+   850   850   850   850  -160    /* AU,GC,U,G */+  -160  -160  -160  -160  -160    /* AU,GC,U,U */+  1350  1350  1350  1350  1350    /* AU,GU,E,E */+  1350  1350  1350  1350  1350    /* AU,GU,E,A */+  1350  1350  1350  1350  1350    /* AU,GU,E,C */+  1350  1350  1350  1350  1350    /* AU,GU,E,G */+  1350  1350  1350  1350  1350    /* AU,GU,E,U */+  1350  1350  1350  1350  1350    /* AU,GU,A,E */+  1350  1350  1350  1350  1350    /* AU,GU,A,A */+  1350  1350  1350  1350  1350    /* AU,GU,A,C */+   780   780   780   780   780    /* AU,GU,A,G */+  1350  1350  1350  1350  1350    /* AU,GU,A,U */+  1350  1350  1350  1350  1350    /* AU,GU,C,E */+  1350  1350  1350  1350  1350    /* AU,GU,C,A */+  1350  1350  1350  1350  1350    /* AU,GU,C,C */+  1350  1350  1350  1350  1350    /* AU,GU,C,G */+  1350  1350  1350  1350  1350    /* AU,GU,C,U */+  1350   780  1350   780  1350    /* AU,GU,G,E */+  1350   780  1350   780  1350    /* AU,GU,G,A */+  1350   780  1350   780  1350    /* AU,GU,G,C */+   780   780   780   780   780    /* AU,GU,G,G */+  1350   780  1350   780  1350    /* AU,GU,G,U */+  1350  1350  1350  1350   340    /* AU,GU,U,E */+  1350  1350  1350  1350   340    /* AU,GU,U,A */+  1350  1350  1350  1350   340    /* AU,GU,U,C */+  1350  1350  1350  1350   340    /* AU,GU,U,G */+   340   340   340   340   340    /* AU,GU,U,U */+  1350  1350  1350  1350  1350    /* AU,UG,E,E */+  1350  1350  1350  1350  1350    /* AU,UG,E,A */+  1350  1350  1350  1350  1350    /* AU,UG,E,C */+  1350  1350  1350  1350  1350    /* AU,UG,E,G */+  1350  1350  1350  1350  1350    /* AU,UG,E,U */+  1350  1350  1350  1350  1350    /* AU,UG,A,E */+  1350  1350  1350  1350  1350    /* AU,UG,A,A */+  1350  1350  1350  1350  1350    /* AU,UG,A,C */+   780   780   780   780   780    /* AU,UG,A,G */+  1350  1350  1350  1350  1350    /* AU,UG,A,U */+  1350  1350  1350  1350  1350    /* AU,UG,C,E */+  1350  1350  1350  1350  1350    /* AU,UG,C,A */+  1350  1350  1350  1350  1350    /* AU,UG,C,C */+  1350  1350  1350  1350  1350    /* AU,UG,C,G */+  1350  1350  1350  1350  1350    /* AU,UG,C,U */+  1350   780  1350   780  1350    /* AU,UG,G,E */+   780   780   780   780   780    /* AU,UG,G,A */+  1350   780  1350   780  1350    /* AU,UG,G,C */+   780   780   780   780   780    /* AU,UG,G,G */+  1350   780  1350   780  1350    /* AU,UG,G,U */+  1350  1350  1350  1350   340    /* AU,UG,U,E */+  1350  1350  1350  1350   340    /* AU,UG,U,A */+  1350  1350  1350  1350   340    /* AU,UG,U,C */+  1350  1350  1350  1350   340    /* AU,UG,U,G */+   340   340   340   340   340    /* AU,UG,U,U */+  1350  1350  1350  1350  1350    /* AU,AU,E,E */+  1350  1350  1350  1350  1350    /* AU,AU,E,A */+  1350  1350  1350  1350  1350    /* AU,AU,E,C */+  1350  1350  1350  1350  1350    /* AU,AU,E,G */+  1350  1350  1350  1350  1350    /* AU,AU,E,U */+  1350  1350  1350  1350  1350    /* AU,AU,A,E */+  1350  1350  1350  1350  1350    /* AU,AU,A,A */+  1350  1350  1350  1350  1350    /* AU,AU,A,C */+   780   780   780   780   780    /* AU,AU,A,G */+  1350  1350  1350  1350  1350    /* AU,AU,A,U */+  1350  1350  1350  1350  1350    /* AU,AU,C,E */+  1350  1350  1350  1350  1350    /* AU,AU,C,A */+  1350  1350  1350  1350  1350    /* AU,AU,C,C */+  1350  1350  1350  1350  1350    /* AU,AU,C,G */+  1350  1350  1350  1350  1350    /* AU,AU,C,U */+  1350   780  1350   780  1350    /* AU,AU,G,E */+  1350   780  1350   780  1350    /* AU,AU,G,A */+  1350   780  1350   780  1350    /* AU,AU,G,C */+   780   780   780   780   780    /* AU,AU,G,G */+  1350   780  1350   780  1350    /* AU,AU,G,U */+  1350  1350  1350  1350   340    /* AU,AU,U,E */+  1350  1350  1350  1350   340    /* AU,AU,U,A */+  1350  1350  1350  1350   340    /* AU,AU,U,C */+  1350  1350  1350  1350   340    /* AU,AU,U,G */+   340   340   340   340   340    /* AU,AU,U,U */+  1350  1350  1350  1350  1350    /* AU,UA,E,E */+  1350  1350  1350  1350  1350    /* AU,UA,E,A */+  1350  1350  1350  1350  1350    /* AU,UA,E,C */+  1350  1350  1350  1350  1350    /* AU,UA,E,G */+  1350  1350  1350  1350  1350    /* AU,UA,E,U */+  1350  1350  1350  1350  1350    /* AU,UA,A,E */+  1350  1350  1350  1350  1350    /* AU,UA,A,A */+  1350  1350  1350  1350  1350    /* AU,UA,A,C */+   780   780   780   780   780    /* AU,UA,A,G */+  1350  1350  1350  1350  1350    /* AU,UA,A,U */+  1350  1350  1350  1350  1350    /* AU,UA,C,E */+  1350  1350  1350  1350  1350    /* AU,UA,C,A */+  1350  1350  1350  1350  1350    /* AU,UA,C,C */+  1350  1350  1350  1350  1350    /* AU,UA,C,G */+  1350  1350  1350  1350  1350    /* AU,UA,C,U */+  1350   780  1350   780  1350    /* AU,UA,G,E */+   780   780   780   780   780    /* AU,UA,G,A */+  1350   780  1350   780  1350    /* AU,UA,G,C */+   780   780   780   780   780    /* AU,UA,G,G */+  1350   780  1350   780  1350    /* AU,UA,G,U */+  1350  1350  1350  1350   340    /* AU,UA,U,E */+  1350  1350  1350  1350   340    /* AU,UA,U,A */+  1350  1350  1350  1350   340    /* AU,UA,U,C */+  1350  1350  1350  1350   340    /* AU,UA,U,G */+   340   340   340   340   340    /* AU,UA,U,U */+  1350  1350  1350  1350  1350    /* AU,NS,E,E */+  1350  1350  1350  1350  1350    /* AU,NS,E,A */+  1350  1350  1350  1350  1350    /* AU,NS,E,C */+  1350  1350  1350  1350  1350    /* AU,NS,E,G */+  1350  1350  1350  1350  1350    /* AU,NS,E,U */+  1350  1350  1350  1350  1350    /* AU,NS,A,E */+  1350  1350  1350  1350  1350    /* AU,NS,A,A */+  1350  1350  1350  1350  1350    /* AU,NS,A,C */+   780   780   780   780   780    /* AU,NS,A,G */+  1350  1350  1350  1350  1350    /* AU,NS,A,U */+  1350  1350  1350  1350  1350    /* AU,NS,C,E */+  1350  1350  1350  1350  1350    /* AU,NS,C,A */+  1350  1350  1350  1350  1350    /* AU,NS,C,C */+  1350  1350  1350  1350  1350    /* AU,NS,C,G */+  1350  1350  1350  1350  1350    /* AU,NS,C,U */+  1350   780  1350   780  1350    /* AU,NS,G,E */+  1350   780  1350   780  1350    /* AU,NS,G,A */+  1350   780  1350   780  1350    /* AU,NS,G,C */+   780   780   780   780   780    /* AU,NS,G,G */+  1350   780  1350   780  1350    /* AU,NS,G,U */+  1350  1350  1350  1350   340    /* AU,NS,U,E */+  1350  1350  1350  1350   340    /* AU,NS,U,A */+  1350  1350  1350  1350   340    /* AU,NS,U,C */+  1350  1350  1350  1350   340    /* AU,NS,U,G */+   340   340   340   340   340    /* AU,NS,U,U */+   850   850   850   850   850    /* UA,CG,E,E */+   850   850   850   850   850    /* UA,CG,E,A */+   850   850   850   850   850    /* UA,CG,E,C */+   850   850   850   850   850    /* UA,CG,E,G */+   850   850   850   850   850    /* UA,CG,E,U */+   850   850   850   280   850    /* UA,CG,A,E */+   850   850   850   280   850    /* UA,CG,A,A */+   850   850   850   280   850    /* UA,CG,A,C */+   280   280   280   280   280    /* UA,CG,A,G */+   850   850   850   280   850    /* UA,CG,A,U */+   850   850   850   850   850    /* UA,CG,C,E */+   850   850   850   850   850    /* UA,CG,C,A */+   850   850   850   850   850    /* UA,CG,C,C */+   850   850   850   850   850    /* UA,CG,C,G */+   850   850   850   850   850    /* UA,CG,C,U */+   850   280   850   280   850    /* UA,CG,G,E */+   280   280   280   280   280    /* UA,CG,G,A */+   850   280   850   280   850    /* UA,CG,G,C */+   280   280   280   280   280    /* UA,CG,G,G */+   850   280   850   280   850    /* UA,CG,G,U */+   850   850   850   850  -160    /* UA,CG,U,E */+   850   850   850   850  -160    /* UA,CG,U,A */+   850   850   850   850  -160    /* UA,CG,U,C */+   850   850   850   850  -160    /* UA,CG,U,G */+  -160  -160  -160  -160  -160    /* UA,CG,U,U */+   850   850   850   850   850    /* UA,GC,E,E */+   850   850   850   850   850    /* UA,GC,E,A */+   850   850   850   850   850    /* UA,GC,E,C */+   850   850   850   850   850    /* UA,GC,E,G */+   850   850   850   850   850    /* UA,GC,E,U */+   850   850   850   280   850    /* UA,GC,A,E */+   850   850   850   280   850    /* UA,GC,A,A */+   850   850   850   280   850    /* UA,GC,A,C */+   280   280   280   280   280    /* UA,GC,A,G */+   850   850   850   280   850    /* UA,GC,A,U */+   850   850   850   850   850    /* UA,GC,C,E */+   850   850   850   850   850    /* UA,GC,C,A */+   850   850   850   850   850    /* UA,GC,C,C */+   850   850   850   850   850    /* UA,GC,C,G */+   850   850   850   850   850    /* UA,GC,C,U */+   850   280   850   280   850    /* UA,GC,G,E */+   850   280   850   280   850    /* UA,GC,G,A */+   850   280   850   280   850    /* UA,GC,G,C */+   280   280   280   280   280    /* UA,GC,G,G */+   850   280   850   280   850    /* UA,GC,G,U */+   850   850   850   850  -160    /* UA,GC,U,E */+   850   850   850   850  -160    /* UA,GC,U,A */+   850   850   850   850  -160    /* UA,GC,U,C */+   850   850   850   850  -160    /* UA,GC,U,G */+  -160  -160  -160  -160  -160    /* UA,GC,U,U */+  1350  1350  1350  1350  1350    /* UA,GU,E,E */+  1350  1350  1350  1350  1350    /* UA,GU,E,A */+  1350  1350  1350  1350  1350    /* UA,GU,E,C */+  1350  1350  1350  1350  1350    /* UA,GU,E,G */+  1350  1350  1350  1350  1350    /* UA,GU,E,U */+  1350  1350  1350   780  1350    /* UA,GU,A,E */+  1350  1350  1350   780  1350    /* UA,GU,A,A */+  1350  1350  1350   780  1350    /* UA,GU,A,C */+   780   780   780   780   780    /* UA,GU,A,G */+  1350  1350  1350   780  1350    /* UA,GU,A,U */+  1350  1350  1350  1350  1350    /* UA,GU,C,E */+  1350  1350  1350  1350  1350    /* UA,GU,C,A */+  1350  1350  1350  1350  1350    /* UA,GU,C,C */+  1350  1350  1350  1350  1350    /* UA,GU,C,G */+  1350  1350  1350  1350  1350    /* UA,GU,C,U */+  1350   780  1350   780  1350    /* UA,GU,G,E */+  1350   780  1350   780  1350    /* UA,GU,G,A */+  1350   780  1350   780  1350    /* UA,GU,G,C */+   780   780   780   780   780    /* UA,GU,G,G */+  1350   780  1350   780  1350    /* UA,GU,G,U */+  1350  1350  1350  1350   340    /* UA,GU,U,E */+  1350  1350  1350  1350   340    /* UA,GU,U,A */+  1350  1350  1350  1350   340    /* UA,GU,U,C */+  1350  1350  1350  1350   340    /* UA,GU,U,G */+   340   340   340   340   340    /* UA,GU,U,U */+  1350  1350  1350  1350  1350    /* UA,UG,E,E */+  1350  1350  1350  1350  1350    /* UA,UG,E,A */+  1350  1350  1350  1350  1350    /* UA,UG,E,C */+  1350  1350  1350  1350  1350    /* UA,UG,E,G */+  1350  1350  1350  1350  1350    /* UA,UG,E,U */+  1350  1350  1350   780  1350    /* UA,UG,A,E */+  1350  1350  1350   780  1350    /* UA,UG,A,A */+  1350  1350  1350   780  1350    /* UA,UG,A,C */+   780   780   780   780   780    /* UA,UG,A,G */+  1350  1350  1350   780  1350    /* UA,UG,A,U */+  1350  1350  1350  1350  1350    /* UA,UG,C,E */+  1350  1350  1350  1350  1350    /* UA,UG,C,A */+  1350  1350  1350  1350  1350    /* UA,UG,C,C */+  1350  1350  1350  1350  1350    /* UA,UG,C,G */+  1350  1350  1350  1350  1350    /* UA,UG,C,U */+  1350   780  1350   780  1350    /* UA,UG,G,E */+   780   780   780   780   780    /* UA,UG,G,A */+  1350   780  1350   780  1350    /* UA,UG,G,C */+   780   780   780   780   780    /* UA,UG,G,G */+  1350   780  1350   780  1350    /* UA,UG,G,U */+  1350  1350  1350  1350   340    /* UA,UG,U,E */+  1350  1350  1350  1350   340    /* UA,UG,U,A */+  1350  1350  1350  1350   340    /* UA,UG,U,C */+  1350  1350  1350  1350   340    /* UA,UG,U,G */+   340   340   340   340   340    /* UA,UG,U,U */+  1350  1350  1350  1350  1350    /* UA,AU,E,E */+  1350  1350  1350  1350  1350    /* UA,AU,E,A */+  1350  1350  1350  1350  1350    /* UA,AU,E,C */+  1350  1350  1350  1350  1350    /* UA,AU,E,G */+  1350  1350  1350  1350  1350    /* UA,AU,E,U */+  1350  1350  1350   780  1350    /* UA,AU,A,E */+  1350  1350  1350   780  1350    /* UA,AU,A,A */+  1350  1350  1350   780  1350    /* UA,AU,A,C */+   780   780   780   780   780    /* UA,AU,A,G */+  1350  1350  1350   780  1350    /* UA,AU,A,U */+  1350  1350  1350  1350  1350    /* UA,AU,C,E */+  1350  1350  1350  1350  1350    /* UA,AU,C,A */+  1350  1350  1350  1350  1350    /* UA,AU,C,C */+  1350  1350  1350  1350  1350    /* UA,AU,C,G */+  1350  1350  1350  1350  1350    /* UA,AU,C,U */+  1350   780  1350   780  1350    /* UA,AU,G,E */+  1350   780  1350   780  1350    /* UA,AU,G,A */+  1350   780  1350   780  1350    /* UA,AU,G,C */+   780   780   780   780   780    /* UA,AU,G,G */+  1350   780  1350   780  1350    /* UA,AU,G,U */+  1350  1350  1350  1350   340    /* UA,AU,U,E */+  1350  1350  1350  1350   340    /* UA,AU,U,A */+  1350  1350  1350  1350   340    /* UA,AU,U,C */+  1350  1350  1350  1350   340    /* UA,AU,U,G */+   340   340   340   340   340    /* UA,AU,U,U */+  1350  1350  1350  1350  1350    /* UA,UA,E,E */+  1350  1350  1350  1350  1350    /* UA,UA,E,A */+  1350  1350  1350  1350  1350    /* UA,UA,E,C */+  1350  1350  1350  1350  1350    /* UA,UA,E,G */+  1350  1350  1350  1350  1350    /* UA,UA,E,U */+  1350  1350  1350   780  1350    /* UA,UA,A,E */+  1350  1350  1350   780  1350    /* UA,UA,A,A */+  1350  1350  1350   780  1350    /* UA,UA,A,C */+   780   780   780   780   780    /* UA,UA,A,G */+  1350  1350  1350   780  1350    /* UA,UA,A,U */+  1350  1350  1350  1350  1350    /* UA,UA,C,E */+  1350  1350  1350  1350  1350    /* UA,UA,C,A */+  1350  1350  1350  1350  1350    /* UA,UA,C,C */+  1350  1350  1350  1350  1350    /* UA,UA,C,G */+  1350  1350  1350  1350  1350    /* UA,UA,C,U */+  1350   780  1350   780  1350    /* UA,UA,G,E */+   780   780   780   780   780    /* UA,UA,G,A */+  1350   780  1350   780  1350    /* UA,UA,G,C */+   780   780   780   780   780    /* UA,UA,G,G */+  1350   780  1350   780  1350    /* UA,UA,G,U */+  1350  1350  1350  1350   340    /* UA,UA,U,E */+  1350  1350  1350  1350   340    /* UA,UA,U,A */+  1350  1350  1350  1350   340    /* UA,UA,U,C */+  1350  1350  1350  1350   340    /* UA,UA,U,G */+   340   340   340   340   340    /* UA,UA,U,U */+  1350  1350  1350  1350  1350    /* UA,NS,E,E */+  1350  1350  1350  1350  1350    /* UA,NS,E,A */+  1350  1350  1350  1350  1350    /* UA,NS,E,C */+  1350  1350  1350  1350  1350    /* UA,NS,E,G */+  1350  1350  1350  1350  1350    /* UA,NS,E,U */+  1350  1350  1350   780  1350    /* UA,NS,A,E */+  1350  1350  1350   780  1350    /* UA,NS,A,A */+  1350  1350  1350   780  1350    /* UA,NS,A,C */+   780   780   780   780   780    /* UA,NS,A,G */+  1350  1350  1350   780  1350    /* UA,NS,A,U */+  1350  1350  1350  1350  1350    /* UA,NS,C,E */+  1350  1350  1350  1350  1350    /* UA,NS,C,A */+  1350  1350  1350  1350  1350    /* UA,NS,C,C */+  1350  1350  1350  1350  1350    /* UA,NS,C,G */+  1350  1350  1350  1350  1350    /* UA,NS,C,U */+  1350   780  1350   780  1350    /* UA,NS,G,E */+  1350   780  1350   780  1350    /* UA,NS,G,A */+  1350   780  1350   780  1350    /* UA,NS,G,C */+   780   780   780   780   780    /* UA,NS,G,G */+  1350   780  1350   780  1350    /* UA,NS,G,U */+  1350  1350  1350  1350   340    /* UA,NS,U,E */+  1350  1350  1350  1350   340    /* UA,NS,U,A */+  1350  1350  1350  1350   340    /* UA,NS,U,C */+  1350  1350  1350  1350   340    /* UA,NS,U,G */+   340   340   340   340   340    /* UA,NS,U,U */+   850   850   850   850   850    /* NS,CG,E,E */+   850   850   850   850   850    /* NS,CG,E,A */+   850   850   850   850   850    /* NS,CG,E,C */+   850   850   850   850   850    /* NS,CG,E,G */+   850   850   850   850   850    /* NS,CG,E,U */+   850   850   850   850   850    /* NS,CG,A,E */+   850   850   850   850   850    /* NS,CG,A,A */+   850   850   850   850   850    /* NS,CG,A,C */+   280   280   280   280   280    /* NS,CG,A,G */+   850   850   850   850   850    /* NS,CG,A,U */+   850   850   850   850   850    /* NS,CG,C,E */+   850   850   850   850   850    /* NS,CG,C,A */+   850   850   850   850   850    /* NS,CG,C,C */+   850   850   850   850   850    /* NS,CG,C,G */+   850   850   850   850   850    /* NS,CG,C,U */+   850   280   850   280   850    /* NS,CG,G,E */+   280   280   280   280   280    /* NS,CG,G,A */+   850   280   850   280   850    /* NS,CG,G,C */+   280   280   280   280   280    /* NS,CG,G,G */+   850   280   850   280   850    /* NS,CG,G,U */+   850   850   850   850  -160    /* NS,CG,U,E */+   850   850   850   850  -160    /* NS,CG,U,A */+   850   850   850   850  -160    /* NS,CG,U,C */+   850   850   850   850  -160    /* NS,CG,U,G */+  -160  -160  -160  -160  -160    /* NS,CG,U,U */+   850   850   850   850   850    /* NS,GC,E,E */+   850   850   850   850   850    /* NS,GC,E,A */+   850   850   850   850   850    /* NS,GC,E,C */+   850   850   850   850   850    /* NS,GC,E,G */+   850   850   850   850   850    /* NS,GC,E,U */+   850   850   850   850   850    /* NS,GC,A,E */+   850   850   850   850   850    /* NS,GC,A,A */+   850   850   850   850   850    /* NS,GC,A,C */+   280   280   280   280   280    /* NS,GC,A,G */+   850   850   850   850   850    /* NS,GC,A,U */+   850   850   850   850   850    /* NS,GC,C,E */+   850   850   850   850   850    /* NS,GC,C,A */+   850   850   850   850   850    /* NS,GC,C,C */+   850   850   850   850   850    /* NS,GC,C,G */+   850   850   850   850   850    /* NS,GC,C,U */+   850   280   850   280   850    /* NS,GC,G,E */+   850   280   850   280   850    /* NS,GC,G,A */+   850   280   850   280   850    /* NS,GC,G,C */+   280   280   280   280   280    /* NS,GC,G,G */+   850   280   850   280   850    /* NS,GC,G,U */+   850   850   850   850  -160    /* NS,GC,U,E */+   850   850   850   850  -160    /* NS,GC,U,A */+   850   850   850   850  -160    /* NS,GC,U,C */+   850   850   850   850  -160    /* NS,GC,U,G */+  -160  -160  -160  -160  -160    /* NS,GC,U,U */+  1350  1350  1350  1350  1350    /* NS,GU,E,E */+  1350  1350  1350  1350  1350    /* NS,GU,E,A */+  1350  1350  1350  1350  1350    /* NS,GU,E,C */+  1350  1350  1350  1350  1350    /* NS,GU,E,G */+  1350  1350  1350  1350  1350    /* NS,GU,E,U */+  1350  1350  1350  1350  1350    /* NS,GU,A,E */+  1350  1350  1350  1350  1350    /* NS,GU,A,A */+  1350  1350  1350  1350  1350    /* NS,GU,A,C */+   780   780   780   780   780    /* NS,GU,A,G */+  1350  1350  1350  1350  1350    /* NS,GU,A,U */+  1350  1350  1350  1350  1350    /* NS,GU,C,E */+  1350  1350  1350  1350  1350    /* NS,GU,C,A */+  1350  1350  1350  1350  1350    /* NS,GU,C,C */+  1350  1350  1350  1350  1350    /* NS,GU,C,G */+  1350  1350  1350  1350  1350    /* NS,GU,C,U */+  1350   780  1350   780  1350    /* NS,GU,G,E */+  1350   780  1350   780  1350    /* NS,GU,G,A */+  1350   780  1350   780  1350    /* NS,GU,G,C */+   780   780   780   780   780    /* NS,GU,G,G */+  1350   780  1350   780  1350    /* NS,GU,G,U */+  1350  1350  1350  1350   340    /* NS,GU,U,E */+  1350  1350  1350  1350   340    /* NS,GU,U,A */+  1350  1350  1350  1350   340    /* NS,GU,U,C */+  1350  1350  1350  1350   340    /* NS,GU,U,G */+   340   340   340   340   340    /* NS,GU,U,U */+  1350  1350  1350  1350  1350    /* NS,UG,E,E */+  1350  1350  1350  1350  1350    /* NS,UG,E,A */+  1350  1350  1350  1350  1350    /* NS,UG,E,C */+  1350  1350  1350  1350  1350    /* NS,UG,E,G */+  1350  1350  1350  1350  1350    /* NS,UG,E,U */+  1350  1350  1350  1350  1350    /* NS,UG,A,E */+  1350  1350  1350  1350  1350    /* NS,UG,A,A */+  1350  1350  1350  1350  1350    /* NS,UG,A,C */+   780   780   780   780   780    /* NS,UG,A,G */+  1350  1350  1350  1350  1350    /* NS,UG,A,U */+  1350  1350  1350  1350  1350    /* NS,UG,C,E */+  1350  1350  1350  1350  1350    /* NS,UG,C,A */+  1350  1350  1350  1350  1350    /* NS,UG,C,C */+  1350  1350  1350  1350  1350    /* NS,UG,C,G */+  1350  1350  1350  1350  1350    /* NS,UG,C,U */+  1350   780  1350   780  1350    /* NS,UG,G,E */+   780   780   780   780   780    /* NS,UG,G,A */+  1350   780  1350   780  1350    /* NS,UG,G,C */+   780   780   780   780   780    /* NS,UG,G,G */+  1350   780  1350   780  1350    /* NS,UG,G,U */+  1350  1350  1350  1350   340    /* NS,UG,U,E */+  1350  1350  1350  1350   340    /* NS,UG,U,A */+  1350  1350  1350  1350   340    /* NS,UG,U,C */+  1350  1350  1350  1350   340    /* NS,UG,U,G */+   340   340   340   340   340    /* NS,UG,U,U */+  1350  1350  1350  1350  1350    /* NS,AU,E,E */+  1350  1350  1350  1350  1350    /* NS,AU,E,A */+  1350  1350  1350  1350  1350    /* NS,AU,E,C */+  1350  1350  1350  1350  1350    /* NS,AU,E,G */+  1350  1350  1350  1350  1350    /* NS,AU,E,U */+  1350  1350  1350  1350  1350    /* NS,AU,A,E */+  1350  1350  1350  1350  1350    /* NS,AU,A,A */+  1350  1350  1350  1350  1350    /* NS,AU,A,C */+   780   780   780   780   780    /* NS,AU,A,G */+  1350  1350  1350  1350  1350    /* NS,AU,A,U */+  1350  1350  1350  1350  1350    /* NS,AU,C,E */+  1350  1350  1350  1350  1350    /* NS,AU,C,A */+  1350  1350  1350  1350  1350    /* NS,AU,C,C */+  1350  1350  1350  1350  1350    /* NS,AU,C,G */+  1350  1350  1350  1350  1350    /* NS,AU,C,U */+  1350   780  1350   780  1350    /* NS,AU,G,E */+  1350   780  1350   780  1350    /* NS,AU,G,A */+  1350   780  1350   780  1350    /* NS,AU,G,C */+   780   780   780   780   780    /* NS,AU,G,G */+  1350   780  1350   780  1350    /* NS,AU,G,U */+  1350  1350  1350  1350   340    /* NS,AU,U,E */+  1350  1350  1350  1350   340    /* NS,AU,U,A */+  1350  1350  1350  1350   340    /* NS,AU,U,C */+  1350  1350  1350  1350   340    /* NS,AU,U,G */+   340   340   340   340   340    /* NS,AU,U,U */+  1350  1350  1350  1350  1350    /* NS,UA,E,E */+  1350  1350  1350  1350  1350    /* NS,UA,E,A */+  1350  1350  1350  1350  1350    /* NS,UA,E,C */+  1350  1350  1350  1350  1350    /* NS,UA,E,G */+  1350  1350  1350  1350  1350    /* NS,UA,E,U */+  1350  1350  1350  1350  1350    /* NS,UA,A,E */+  1350  1350  1350  1350  1350    /* NS,UA,A,A */+  1350  1350  1350  1350  1350    /* NS,UA,A,C */+   780   780   780   780   780    /* NS,UA,A,G */+  1350  1350  1350  1350  1350    /* NS,UA,A,U */+  1350  1350  1350  1350  1350    /* NS,UA,C,E */+  1350  1350  1350  1350  1350    /* NS,UA,C,A */+  1350  1350  1350  1350  1350    /* NS,UA,C,C */+  1350  1350  1350  1350  1350    /* NS,UA,C,G */+  1350  1350  1350  1350  1350    /* NS,UA,C,U */+  1350   780  1350   780  1350    /* NS,UA,G,E */+   780   780   780   780   780    /* NS,UA,G,A */+  1350   780  1350   780  1350    /* NS,UA,G,C */+   780   780   780   780   780    /* NS,UA,G,G */+  1350   780  1350   780  1350    /* NS,UA,G,U */+  1350  1350  1350  1350   340    /* NS,UA,U,E */+  1350  1350  1350  1350   340    /* NS,UA,U,A */+  1350  1350  1350  1350   340    /* NS,UA,U,C */+  1350  1350  1350  1350   340    /* NS,UA,U,G */+   340   340   340   340   340    /* NS,UA,U,U */+  1350  1350  1350  1350  1350    /* NS,NS,E,E */+  1350  1350  1350  1350  1350    /* NS,NS,E,A */+  1350  1350  1350  1350  1350    /* NS,NS,E,C */+  1350  1350  1350  1350  1350    /* NS,NS,E,G */+  1350  1350  1350  1350  1350    /* NS,NS,E,U */+  1350  1350  1350  1350  1350    /* NS,NS,A,E */+  1350  1350  1350  1350  1350    /* NS,NS,A,A */+  1350  1350  1350  1350  1350    /* NS,NS,A,C */+   780   780   780   780   780    /* NS,NS,A,G */+  1350  1350  1350  1350  1350    /* NS,NS,A,U */+  1350  1350  1350  1350  1350    /* NS,NS,C,E */+  1350  1350  1350  1350  1350    /* NS,NS,C,A */+  1350  1350  1350  1350  1350    /* NS,NS,C,C */+  1350  1350  1350  1350  1350    /* NS,NS,C,G */+  1350  1350  1350  1350  1350    /* NS,NS,C,U */+  1350   780  1350   780  1350    /* NS,NS,G,E */+  1350   780  1350   780  1350    /* NS,NS,G,A */+  1350   780  1350   780  1350    /* NS,NS,G,C */+   780   780   780   780   780    /* NS,NS,G,G */+  1350   780  1350   780  1350    /* NS,NS,G,U */+  1350  1350  1350  1350   340    /* NS,NS,U,E */+  1350  1350  1350  1350   340    /* NS,NS,U,A */+  1350  1350  1350  1350   340    /* NS,NS,U,C */+  1350  1350  1350  1350   340    /* NS,NS,U,G */+   340   340   340   340   340    /* NS,NS,U,U */++# int22+   120   160    20   160    /* CG,CG,A,A,A */+   110   150    20   150    /* CG,CG,A,A,C */+    20    60   -70    60    /* CG,CG,A,A,G */+   110   150    20   150    /* CG,CG,A,A,U */+   160   200    60   200    /* CG,CG,A,C,A */+   140   180   110   180    /* CG,CG,A,C,C */+   160   200    60   200    /* CG,CG,A,C,G */+   130   170    90   170    /* CG,CG,A,C,U */+    20    60   -70    60    /* CG,CG,A,G,A */+   110   150    20   150    /* CG,CG,A,G,C */+   -30    10     0    10    /* CG,CG,A,G,G */+   110   150    20   150    /* CG,CG,A,G,U */+   160   200    60   200    /* CG,CG,A,U,A */+   130   170    90   170    /* CG,CG,A,U,C */+   160   200    60   200    /* CG,CG,A,U,G */+   100    80   -50    80    /* CG,CG,A,U,U */+   110   140   110   130    /* CG,CG,C,A,A */+   110   140   110   120    /* CG,CG,C,A,C */+    20   110    20    90    /* CG,CG,C,A,G */+   110   140   110   120    /* CG,CG,C,A,U */+   150   180   150   170    /* CG,CG,C,C,A */+   140   170   140   150    /* CG,CG,C,C,C */+   150   180   150   170    /* CG,CG,C,C,G */+   120   150   120   140    /* CG,CG,C,C,U */+    20   110    20    90    /* CG,CG,C,G,A */+   110   140   110   120    /* CG,CG,C,G,C */+   -40   -10   -40   -20    /* CG,CG,C,G,G */+   110   140   110   120    /* CG,CG,C,G,U */+   150   180   150   170    /* CG,CG,C,U,A */+   120   150   120   140    /* CG,CG,C,U,C */+   150   180   150   170    /* CG,CG,C,U,G */+    30    60    30    50    /* CG,CG,C,U,U */+    20   160   -30   160    /* CG,CG,G,A,A */+    20   150   -40   150    /* CG,CG,G,A,C */+   -70    60     0    60    /* CG,CG,G,A,G */+    20   150   -40   150    /* CG,CG,G,A,U */+    60   200    10   200    /* CG,CG,G,C,A */+   110   180   -10   180    /* CG,CG,G,C,C */+    60   200    10   200    /* CG,CG,G,C,G */+    90   170   -20   170    /* CG,CG,G,C,U */+   -70    60     0    60    /* CG,CG,G,G,A */+    20   150   -40   150    /* CG,CG,G,G,C */+     0    10    80    10    /* CG,CG,G,G,G */+    20   150   -40   150    /* CG,CG,G,G,U */+    60   200    10   200    /* CG,CG,G,U,A */+    90   170   -20   170    /* CG,CG,G,U,C */+    60   200    10   200    /* CG,CG,G,U,G */+   -50    80    20    80    /* CG,CG,G,U,U */+   110   130   110   100    /* CG,CG,U,A,A */+   110   120   110    30    /* CG,CG,U,A,C */+    20    90    20   -50    /* CG,CG,U,A,G */+   110   120   110    30    /* CG,CG,U,A,U */+   150   170   150    80    /* CG,CG,U,C,A */+   140   150   140    60    /* CG,CG,U,C,C */+   150   170   150    80    /* CG,CG,U,C,G */+   120   140   120    50    /* CG,CG,U,C,U */+    20    90    20   -50    /* CG,CG,U,G,A */+   110   120   110    30    /* CG,CG,U,G,C */+   -40   -20   -40    20    /* CG,CG,U,G,G */+   110   120   110    30    /* CG,CG,U,G,U */+   150   170   150    80    /* CG,CG,U,U,A */+   120   140   120    50    /* CG,CG,U,U,C */+   150   170   150    80    /* CG,CG,U,U,G */+    30    50    30   -40    /* CG,CG,U,U,U */+   130    60     0   170    /* CG,GC,A,A,A */+   110   150   -70   150    /* CG,GC,A,A,C */+   -30    10  -160   -30    /* CG,GC,A,A,G */+   110   150    10   150    /* CG,GC,A,A,U */+   100    50  -100   140    /* CG,GC,A,C,A */+   110   150   -60   150    /* CG,GC,A,C,C */+   100   140    10   140    /* CG,GC,A,C,G */+   110   150    70   150    /* CG,GC,A,C,U */+    40    30   -70    30    /* CG,GC,A,G,A */+   110   150    10   150    /* CG,GC,A,G,C */+   -30   -30     0    10    /* CG,GC,A,G,G */+   110   150    10   150    /* CG,GC,A,G,U */+   100   140    10   140    /* CG,GC,A,U,A */+   110   150    80   150    /* CG,GC,A,U,C */+   100   140    10   140    /* CG,GC,A,U,G */+   150     0    90    70    /* CG,GC,A,U,U */+   130   220   130   140    /* CG,GC,C,A,A */+   100   130   100   120    /* CG,GC,C,A,C */+   -70    70   -70     0    /* CG,GC,C,A,G */+   100   130   100   120    /* CG,GC,C,A,U */+   110   190   100   110    /* CG,GC,C,C,A */+   100   130   100   120    /* CG,GC,C,C,C */+   100   130   100   110    /* CG,GC,C,C,G */+   100   130   100   170    /* CG,GC,C,C,U */+    70    70   -10    60    /* CG,GC,C,G,A */+   100   130   100   120    /* CG,GC,C,G,C */+   -40   -10   -40    20    /* CG,GC,C,G,G */+   100   130   100   120    /* CG,GC,C,G,U */+   100   130   100   110    /* CG,GC,C,U,A */+   110   140   110   120    /* CG,GC,C,U,C */+   100   130   100   110    /* CG,GC,C,U,G */+   -20   -10    30    20    /* CG,GC,C,U,U */+   -20   170   -10   170    /* CG,GC,G,A,A */+   -40   150   -40   150    /* CG,GC,G,A,C */+  -170   -30   -90   -30    /* CG,GC,G,A,G */+    10   150   -40   150    /* CG,GC,G,A,U */+    70   140   -50   140    /* CG,GC,G,C,A */+    70   150   -40   150    /* CG,GC,G,C,C */+    10   140   -50   140    /* CG,GC,G,C,G */+    70   150    20   150    /* CG,GC,G,C,U */+   -50    30   -30    30    /* CG,GC,G,G,A */+    10   150   -40   150    /* CG,GC,G,G,C */+   -30    10    80    10    /* CG,GC,G,G,G */+    10   150   -40   150    /* CG,GC,G,G,U */+    10   140   -50   140    /* CG,GC,G,U,A */+    80   150   -50   150    /* CG,GC,G,U,C */+    10   140   -50   140    /* CG,GC,G,U,G */+    90    70   140    70    /* CG,GC,G,U,U */+   130   140   130   140    /* CG,GC,U,A,A */+   100   120   100    30    /* CG,GC,U,A,C */+   -70     0   -70    50    /* CG,GC,U,A,G */+   100   120   100    30    /* CG,GC,U,A,U */+   100   110   100    30    /* CG,GC,U,C,A */+   100   120   100    30    /* CG,GC,U,C,C */+   100   110   100    20    /* CG,GC,U,C,G */+   100   120   100    30    /* CG,GC,U,C,U */+   -10    50   -10   140    /* CG,GC,U,G,A */+   100   120   100    30    /* CG,GC,U,G,C */+   -40   -60   -40    70    /* CG,GC,U,G,G */+   100   120   100    30    /* CG,GC,U,G,U */+   100   110   100    20    /* CG,GC,U,U,A */+   110   120   110    30    /* CG,GC,U,U,C */+   100   110   100    20    /* CG,GC,U,U,G */+    30    40    30   -60    /* CG,GC,U,U,U */+   270   300   170   300    /* CG,GU,A,A,A */+   230   270   130   270    /* CG,GU,A,A,C */+   150   190    50   190    /* CG,GU,A,A,G */+   230   270   130   270    /* CG,GU,A,A,U */+   230   270   130   270    /* CG,GU,A,C,A */+   230   270   190   270    /* CG,GU,A,C,C */+   230   270   130   270    /* CG,GU,A,C,G */+   230   270   190   270    /* CG,GU,A,C,U */+   190   230    90   230    /* CG,GU,A,G,A */+   230   270   130   270    /* CG,GU,A,G,C */+   100   140   130   140    /* CG,GU,A,G,G */+   230   270   130   270    /* CG,GU,A,G,U */+   230   270   130   270    /* CG,GU,A,U,A */+   230   270   190   270    /* CG,GU,A,U,C */+   230   270   130   270    /* CG,GU,A,U,G */+   290   270   130   270    /* CG,GU,A,U,U */+   260   290   260   270    /* CG,GU,C,A,A */+   220   250   220   240    /* CG,GU,C,A,C */+   140   230   140   220    /* CG,GU,C,A,G */+   220   250   220   240    /* CG,GU,C,A,U */+   220   250   220   240    /* CG,GU,C,C,A */+   220   250   220   240    /* CG,GU,C,C,C */+   220   250   220   240    /* CG,GU,C,C,G */+   220   250   220   240    /* CG,GU,C,C,U */+   180   270   180   260    /* CG,GU,C,G,A */+   220   250   220   240    /* CG,GU,C,G,C */+    90   120    90   110    /* CG,GU,C,G,G */+   220   250   220   240    /* CG,GU,C,G,U */+   220   250   220   240    /* CG,GU,C,U,A */+   220   250   220   240    /* CG,GU,C,U,C */+   220   250   220   240    /* CG,GU,C,U,G */+   220   250   220   240    /* CG,GU,C,U,U */+   170   300   110   300    /* CG,GU,G,A,A */+   130   270    80   270    /* CG,GU,G,A,C */+    50   190   130   190    /* CG,GU,G,A,G */+   130   270    80   270    /* CG,GU,G,A,U */+   130   270    80   270    /* CG,GU,G,C,A */+   190   270    80   270    /* CG,GU,G,C,C */+   130   270    80   270    /* CG,GU,G,C,G */+   190   270    80   270    /* CG,GU,G,C,U */+    90   230   170   230    /* CG,GU,G,G,A */+   130   270    80   270    /* CG,GU,G,G,C */+   130   140   210   140    /* CG,GU,G,G,G */+   130   270    80   270    /* CG,GU,G,G,U */+   130   270    80   270    /* CG,GU,G,U,A */+   190   270    80   270    /* CG,GU,G,U,C */+   130   270    80   270    /* CG,GU,G,U,G */+   130   270   210   270    /* CG,GU,G,U,U */+   260   270   260   240    /* CG,GU,U,A,A */+   220   240   220   150    /* CG,GU,U,A,C */+   140   220   140    70    /* CG,GU,U,A,G */+   220   240   220   150    /* CG,GU,U,A,U */+   220   240   220   150    /* CG,GU,U,C,A */+   220   240   220   150    /* CG,GU,U,C,C */+   220   240   220   150    /* CG,GU,U,C,G */+   220   240   220   150    /* CG,GU,U,C,U */+   180   260   180   110    /* CG,GU,U,G,A */+   220   240   220   150    /* CG,GU,U,G,C */+    90   110    90   150    /* CG,GU,U,G,G */+   220   240   220   150    /* CG,GU,U,G,U */+   220   240   220   150    /* CG,GU,U,U,A */+   220   240   220   150    /* CG,GU,U,U,C */+   220   240   220   150    /* CG,GU,U,U,G */+   220   240   220   150    /* CG,GU,U,U,U */+   160   200    70   200    /* CG,UG,A,A,A */+   200   240   100   240    /* CG,UG,A,A,C */+    60   100   -30   100    /* CG,UG,A,A,G */+   200   240   100   240    /* CG,UG,A,A,U */+   200   240   100   240    /* CG,UG,A,C,A */+   200   240   160   240    /* CG,UG,A,C,C */+   200   240   100   240    /* CG,UG,A,C,G */+   200   240   160   240    /* CG,UG,A,C,U */+   230   270   130   270    /* CG,UG,A,G,A */+   200   240   100   240    /* CG,UG,A,G,C */+    70   110   100   110    /* CG,UG,A,G,G */+   200   240   100   240    /* CG,UG,A,G,U */+   200   240   100   240    /* CG,UG,A,U,A */+   200   240   160   240    /* CG,UG,A,U,C */+   200   240   100   240    /* CG,UG,A,U,G */+   260   240   100   240    /* CG,UG,A,U,U */+   160   190   160   170    /* CG,UG,C,A,A */+   190   220   190   210    /* CG,UG,C,A,C */+    60   150    60   130    /* CG,UG,C,A,G */+   190   220   190   210    /* CG,UG,C,A,U */+   190   220   190   210    /* CG,UG,C,C,A */+   190   220   190   210    /* CG,UG,C,C,C */+   190   220   190   210    /* CG,UG,C,C,G */+   190   220   190   210    /* CG,UG,C,C,U */+   220   310   220   300    /* CG,UG,C,G,A */+   190   220   190   210    /* CG,UG,C,G,C */+    60    90    60    80    /* CG,UG,C,G,G */+   190   220   190   210    /* CG,UG,C,G,U */+   190   220   190   210    /* CG,UG,C,U,A */+   190   220   190   210    /* CG,UG,C,U,C */+   190   220   190   210    /* CG,UG,C,U,G */+   190   220   190   210    /* CG,UG,C,U,U */+    70   200    10   200    /* CG,UG,G,A,A */+   100   240    50   240    /* CG,UG,G,A,C */+   -30   100    40   100    /* CG,UG,G,A,G */+   100   240    50   240    /* CG,UG,G,A,U */+   100   240    50   240    /* CG,UG,G,C,A */+   160   240    50   240    /* CG,UG,G,C,C */+   100   240    50   240    /* CG,UG,G,C,G */+   160   240    50   240    /* CG,UG,G,C,U */+   130   270   210   270    /* CG,UG,G,G,A */+   100   240    50   240    /* CG,UG,G,G,C */+   100   110   180   110    /* CG,UG,G,G,G */+   100   240    50   240    /* CG,UG,G,G,U */+   100   240    50   240    /* CG,UG,G,U,A */+   160   240    50   240    /* CG,UG,G,U,C */+   100   240    50   240    /* CG,UG,G,U,G */+   100   240   180   240    /* CG,UG,G,U,U */+   160   170   160   140    /* CG,UG,U,A,A */+   190   210   190   120    /* CG,UG,U,A,C */+    60   130    60   -10    /* CG,UG,U,A,G */+   190   210   190   120    /* CG,UG,U,A,U */+   190   210   190   120    /* CG,UG,U,C,A */+   190   210   190   120    /* CG,UG,U,C,C */+   190   210   190   120    /* CG,UG,U,C,G */+   190   210   190   120    /* CG,UG,U,C,U */+   220   300   220   150    /* CG,UG,U,G,A */+   190   210   190   120    /* CG,UG,U,G,C */+    60    80    60   120    /* CG,UG,U,G,G */+   190   210   190   120    /* CG,UG,U,G,U */+   190   210   190   120    /* CG,UG,U,U,A */+   190   210   190   120    /* CG,UG,U,U,C */+   190   210   190   120    /* CG,UG,U,U,G */+   190   210   190   120    /* CG,UG,U,U,U */+   200   240   100   240    /* CG,AU,A,A,A */+   170   210    80   210    /* CG,AU,A,A,C */+    70   110   -20   110    /* CG,AU,A,A,G */+   170   210    80   210    /* CG,AU,A,A,U */+   180   220    90   220    /* CG,AU,A,C,A */+   180   220   140   220    /* CG,AU,A,C,C */+   180   220    90   220    /* CG,AU,A,C,G */+   180   220   140   220    /* CG,AU,A,C,U */+   140   180    50   180    /* CG,AU,A,G,A */+   170   210    80   210    /* CG,AU,A,G,C */+    20    60    60    60    /* CG,AU,A,G,G */+   170   210    80   210    /* CG,AU,A,G,U */+   180   220    90   220    /* CG,AU,A,U,A */+   180   220   140   220    /* CG,AU,A,U,C */+   180   220    90   220    /* CG,AU,A,U,G */+   150   130     0   130    /* CG,AU,A,U,U */+   190   220   190   210    /* CG,AU,C,A,A */+   170   200   170   180    /* CG,AU,C,A,C */+    70   160    70   140    /* CG,AU,C,A,G */+   170   200   170   180    /* CG,AU,C,A,U */+   180   210   180   190    /* CG,AU,C,C,A */+   170   200   170   190    /* CG,AU,C,C,C */+   180   210   180   190    /* CG,AU,C,C,G */+   170   200   170   190    /* CG,AU,C,C,U */+   140   230   140   210    /* CG,AU,C,G,A */+   170   200   170   180    /* CG,AU,C,G,C */+    20    50    20    30    /* CG,AU,C,G,G */+   170   200   170   180    /* CG,AU,C,G,U */+   180   210   180   190    /* CG,AU,C,U,A */+   170   200   170   190    /* CG,AU,C,U,C */+   180   210   180   190    /* CG,AU,C,U,G */+    80   110    80   100    /* CG,AU,C,U,U */+   100   240    50   240    /* CG,AU,G,A,A */+    80   210    20   210    /* CG,AU,G,A,C */+   -20   110    50   110    /* CG,AU,G,A,G */+    80   210    20   210    /* CG,AU,G,A,U */+    90   220    30   220    /* CG,AU,G,C,A */+   140   220    30   220    /* CG,AU,G,C,C */+    90   220    30   220    /* CG,AU,G,C,G */+   140   220    30   220    /* CG,AU,G,C,U */+    50   180   120   180    /* CG,AU,G,G,A */+    80   210    20   210    /* CG,AU,G,G,C */+    60    60   130    60    /* CG,AU,G,G,G */+    80   210    20   210    /* CG,AU,G,G,U */+    90   220    30   220    /* CG,AU,G,U,A */+   140   220    30   220    /* CG,AU,G,U,C */+    90   220    30   220    /* CG,AU,G,U,G */+     0   130    70   130    /* CG,AU,G,U,U */+   190   210   190   180    /* CG,AU,U,A,A */+   170   180   170    90    /* CG,AU,U,A,C */+    70   140    70     0    /* CG,AU,U,A,G */+   170   180   170    90    /* CG,AU,U,A,U */+   180   190   180   100    /* CG,AU,U,C,A */+   170   190   170   100    /* CG,AU,U,C,C */+   180   190   180   100    /* CG,AU,U,C,G */+   170   190   170   100    /* CG,AU,U,C,U */+   140   210   140    60    /* CG,AU,U,G,A */+   170   180   170    90    /* CG,AU,U,G,C */+    20    30    20    70    /* CG,AU,U,G,G */+   170   180   170    90    /* CG,AU,U,G,U */+   180   190   180   100    /* CG,AU,U,U,A */+   170   190   170   100    /* CG,AU,U,U,C */+   180   190   180   100    /* CG,AU,U,U,G */+    80   100    80    10    /* CG,AU,U,U,U */+   200   240   100   240    /* CG,UA,A,A,A */+   150   190    60   190    /* CG,UA,A,A,C */+    90   130     0   130    /* CG,UA,A,A,G */+   150   190    60   190    /* CG,UA,A,A,U */+   200   240   100   240    /* CG,UA,A,C,A */+   200   240   160   240    /* CG,UA,A,C,C */+   200   240   100   240    /* CG,UA,A,C,G */+   200   240   160   240    /* CG,UA,A,C,U */+   100   140    10   140    /* CG,UA,A,G,A */+   150   190    60   190    /* CG,UA,A,G,C */+    40    80    80    80    /* CG,UA,A,G,G */+   150   190    60   190    /* CG,UA,A,G,U */+   200   240   100   240    /* CG,UA,A,U,A */+   170   210   130   210    /* CG,UA,A,U,C */+   200   240   100   240    /* CG,UA,A,U,G */+   170   150    20   150    /* CG,UA,A,U,U */+   190   220   190   210    /* CG,UA,C,A,A */+   150   180   150   160    /* CG,UA,C,A,C */+    90   180    90   160    /* CG,UA,C,A,G */+   150   180   150   160    /* CG,UA,C,A,U */+   190   220   190   210    /* CG,UA,C,C,A */+   190   220   190   210    /* CG,UA,C,C,C */+   190   220   190   210    /* CG,UA,C,C,G */+   190   220   190   210    /* CG,UA,C,C,U */+   100   190   100   170    /* CG,UA,C,G,A */+   150   180   150   160    /* CG,UA,C,G,C */+    40    70    40    50    /* CG,UA,C,G,G */+   150   180   150   160    /* CG,UA,C,G,U */+   190   220   190   210    /* CG,UA,C,U,A */+   160   190   160   180    /* CG,UA,C,U,C */+   190   220   190   210    /* CG,UA,C,U,G */+   110   140   110   120    /* CG,UA,C,U,U */+   100   240    50   240    /* CG,UA,G,A,A */+    60   190     0   190    /* CG,UA,G,A,C */+     0   130    70   130    /* CG,UA,G,A,G */+    60   190     0   190    /* CG,UA,G,A,U */+   100   240    50   240    /* CG,UA,G,C,A */+   160   240    50   240    /* CG,UA,G,C,C */+   100   240    50   240    /* CG,UA,G,C,G */+   160   240    50   240    /* CG,UA,G,C,U */+    10   140    80   140    /* CG,UA,G,G,A */+    60   190     0   190    /* CG,UA,G,G,C */+    80    80   150    80    /* CG,UA,G,G,G */+    60   190     0   190    /* CG,UA,G,G,U */+   100   240    50   240    /* CG,UA,G,U,A */+   130   210    20   210    /* CG,UA,G,U,C */+   100   240    50   240    /* CG,UA,G,U,G */+    20   150    90   150    /* CG,UA,G,U,U */+   190   210   190   180    /* CG,UA,U,A,A */+   150   160   150    70    /* CG,UA,U,A,C */+    90   160    90    10    /* CG,UA,U,A,G */+   150   160   150    70    /* CG,UA,U,A,U */+   190   210   190   120    /* CG,UA,U,C,A */+   190   210   190   120    /* CG,UA,U,C,C */+   190   210   190   120    /* CG,UA,U,C,G */+   190   210   190   120    /* CG,UA,U,C,U */+   100   170   100    20    /* CG,UA,U,G,A */+   150   160   150    70    /* CG,UA,U,G,C */+    40    50    40    90    /* CG,UA,U,G,G */+   150   160   150    70    /* CG,UA,U,G,U */+   190   210   190   120    /* CG,UA,U,U,A */+   160   180   160    90    /* CG,UA,U,U,C */+   190   210   190   120    /* CG,UA,U,U,G */+   110   120   110    30    /* CG,UA,U,U,U */+   130   100    40   100    /* GC,CG,A,A,A */+   130   110    70   100    /* GC,CG,A,A,C */+   -20    70   -50    10    /* GC,CG,A,A,G */+   130   100   -10   100    /* GC,CG,A,A,U */+    60    50    30   140    /* GC,CG,A,C,A */+   220   190    70   130    /* GC,CG,A,C,C */+   170   140    30   140    /* GC,CG,A,C,G */+   140   110    50   110    /* GC,CG,A,C,U */+     0  -100   -70    10    /* GC,CG,A,G,A */+   130   100   -10   100    /* GC,CG,A,G,C */+   -10   -50   -30   -50    /* GC,CG,A,G,G */+   130   100   -10   100    /* GC,CG,A,G,U */+   170   140    30   140    /* GC,CG,A,U,A */+   140   110    60   110    /* GC,CG,A,U,C */+   170   140    30   140    /* GC,CG,A,U,G */+   140    30   140    20    /* GC,CG,A,U,U */+   110   110   110   110    /* GC,CG,C,A,A */+   100   100   100   110    /* GC,CG,C,A,C */+   -40    70    10    80    /* GC,CG,C,A,G */+   100   100   100   110    /* GC,CG,C,A,U */+   150   150   150   150    /* GC,CG,C,C,A */+   130   130   130   140    /* GC,CG,C,C,C */+   150   150   150   150    /* GC,CG,C,C,G */+   120   120   120   120    /* GC,CG,C,C,U */+   -70   -60    10    80    /* GC,CG,C,G,A */+   100   100   100   110    /* GC,CG,C,G,C */+   -40   -40   -40   -50    /* GC,CG,C,G,G */+   100   100   100   110    /* GC,CG,C,G,U */+   150   150   150   150    /* GC,CG,C,U,A */+   120   120   120   120    /* GC,CG,C,U,C */+   150   150   150   150    /* GC,CG,C,U,G */+    30    30    30    30    /* GC,CG,C,U,U */+   -30   100   -30   100    /* GC,CG,G,A,A */+   -70   100   -40   100    /* GC,CG,G,A,C */+  -170    10   -30    10    /* GC,CG,G,A,G */+   -70   100   -40   100    /* GC,CG,G,A,U */+    10   140   -30   140    /* GC,CG,G,C,A */+    70   130   -10   130    /* GC,CG,G,C,C */+   -30   140    10   140    /* GC,CG,G,C,G */+     0   110   -60   110    /* GC,CG,G,C,U */+  -160    10     0    10    /* GC,CG,G,G,A */+   -70   100   -40   100    /* GC,CG,G,G,C */+   -90   -50    80   -50    /* GC,CG,G,G,G */+   -70   100   -40   100    /* GC,CG,G,G,U */+   -30   140    10   140    /* GC,CG,G,U,A */+     0   110    20   110    /* GC,CG,G,U,C */+   -30   140    10   140    /* GC,CG,G,U,G */+    50    20    70    20    /* GC,CG,G,U,U */+   110   110   110   150    /* GC,CG,U,A,A */+   100   100   100   -20    /* GC,CG,U,A,C */+    10    70    10    90    /* GC,CG,U,A,G */+   100   100   100    30    /* GC,CG,U,A,U */+   150   150   150     0    /* GC,CG,U,C,A */+   130   130   130   -10    /* GC,CG,U,C,C */+   150   150   150    70    /* GC,CG,U,C,G */+   120   120   120    40    /* GC,CG,U,C,U */+    10    70    10    90    /* GC,CG,U,G,A */+   100   100   100    30    /* GC,CG,U,G,C */+   -40    20   -40   140    /* GC,CG,U,G,G */+   100   100   100    30    /* GC,CG,U,G,U */+   150   150   150    70    /* GC,CG,U,U,A */+   120   170   120    20    /* GC,CG,U,U,C */+   150   150   150    70    /* GC,CG,U,U,G */+    30    30    30   -60    /* GC,CG,U,U,U */+   150   120    10   120    /* GC,GC,A,A,A */+   120    90   -10    90    /* GC,GC,A,A,C */+   -50   -80  -190   -80    /* GC,GC,A,A,G */+   120    90   -10    90    /* GC,GC,A,A,U */+   120    90   -20    90    /* GC,GC,A,C,A */+   120    90    50    90    /* GC,GC,A,C,C */+   120    90   -20    90    /* GC,GC,A,C,G */+   120    90    50    90    /* GC,GC,A,C,U */+    10   -20  -130   -20    /* GC,GC,A,G,A */+   120    90   -10    90    /* GC,GC,A,G,C */+   -20   -50   -20   -50    /* GC,GC,A,G,G */+   120    90   -10    90    /* GC,GC,A,G,U */+   120    90   -20    90    /* GC,GC,A,U,A */+   130   100    50   100    /* GC,GC,A,U,C */+   120    90   -20    90    /* GC,GC,A,U,G */+   110    20   -90    20    /* GC,GC,A,U,U */+   120   120   120   130    /* GC,GC,C,A,A */+   100   100   100   100    /* GC,GC,C,A,C */+   -80   -20   -80   -10    /* GC,GC,C,A,G */+   100   100   100   100    /* GC,GC,C,A,U */+    90    90    90   100    /* GC,GC,C,C,A */+   100   100   100   100    /* GC,GC,C,C,C */+    90    90    90   100    /* GC,GC,C,C,G */+   100   100   100   100    /* GC,GC,C,C,U */+   -10    50   -10    50    /* GC,GC,C,G,A */+   100   100   100   100    /* GC,GC,C,G,C */+   -40   -40   -40   -40    /* GC,GC,C,G,G */+   100   100   100   100    /* GC,GC,C,G,U */+    90    90    90   100    /* GC,GC,C,U,A */+   100   100   100   110    /* GC,GC,C,U,C */+    90    90    90   100    /* GC,GC,C,U,G */+    20    20    20    30    /* GC,GC,C,U,U */+   -50   120   -20   120    /* GC,GC,G,A,A */+   -80    90   -40    90    /* GC,GC,G,A,C */+  -260   -80   -90   -80    /* GC,GC,G,A,G */+   -80    90   -40    90    /* GC,GC,G,A,U */+   -80    90   -50    90    /* GC,GC,G,C,A */+   -20    90   -40    90    /* GC,GC,G,C,C */+   -80    90   -50    90    /* GC,GC,G,C,G */+   -20    90   -40    90    /* GC,GC,G,C,U */+  -190   -20   -20   -20    /* GC,GC,G,G,A */+   -80    90   -40    90    /* GC,GC,G,G,C */+   -90   -50    80   -50    /* GC,GC,G,G,G */+   -80    90   -40    90    /* GC,GC,G,G,U */+   -80    90   -50    90    /* GC,GC,G,U,A */+   -10   100   -40   100    /* GC,GC,G,U,C */+   -80    90   -50    90    /* GC,GC,G,U,G */+  -150    20    10    20    /* GC,GC,G,U,U */+   120   120   120   110    /* GC,GC,U,A,A */+   100   100   100    20    /* GC,GC,U,A,C */+   -80   -20   -80  -150    /* GC,GC,U,A,G */+   100   100   100    20    /* GC,GC,U,A,U */+    90    90    90    20    /* GC,GC,U,C,A */+   100   100   100    20    /* GC,GC,U,C,C */+    90    90    90    20    /* GC,GC,U,C,G */+   100   100   100    20    /* GC,GC,U,C,U */+   -10    50   -10   -90    /* GC,GC,U,G,A */+   100   100   100    20    /* GC,GC,U,G,C */+   -40   -40   -40    10    /* GC,GC,U,G,G */+   100   100   100    20    /* GC,GC,U,G,U */+    90    90    90    20    /* GC,GC,U,U,A */+   100   100   100    30    /* GC,GC,U,U,C */+    90    90    90    20    /* GC,GC,U,U,G */+    20    20    20   -50    /* GC,GC,U,U,U */+   280   250   140   250    /* GC,GU,A,A,A */+   240   210   100   210    /* GC,GU,A,A,C */+   160   130    20   130    /* GC,GU,A,A,G */+   240   210   100   210    /* GC,GU,A,A,U */+   240   210   100   210    /* GC,GU,A,C,A */+   240   210   160   210    /* GC,GU,A,C,C */+   240   210   100   210    /* GC,GU,A,C,G */+   240   210   160   210    /* GC,GU,A,C,U */+   200   170    60   170    /* GC,GU,A,G,A */+   240   210   100   210    /* GC,GU,A,G,C */+   110    80   100    80    /* GC,GU,A,G,G */+   240   210   100   210    /* GC,GU,A,G,U */+   240   210   100   210    /* GC,GU,A,U,A */+   240   210   160   210    /* GC,GU,A,U,C */+   240   210   100   210    /* GC,GU,A,U,G */+   300   210   100   210    /* GC,GU,A,U,U */+   250   250   250   260    /* GC,GU,C,A,A */+   220   220   220   220    /* GC,GU,C,A,C */+   140   200   140   200    /* GC,GU,C,A,G */+   220   220   220   220    /* GC,GU,C,A,U */+   220   220   220   220    /* GC,GU,C,C,A */+   220   220   220   220    /* GC,GU,C,C,C */+   220   220   220   220    /* GC,GU,C,C,G */+   220   220   220   220    /* GC,GU,C,C,U */+   180   240   180   240    /* GC,GU,C,G,A */+   220   220   220   220    /* GC,GU,C,G,C */+    90    90    90    90    /* GC,GU,C,G,G */+   220   220   220   220    /* GC,GU,C,G,U */+   220   220   220   220    /* GC,GU,C,U,A */+   220   220   220   220    /* GC,GU,C,U,C */+   220   220   220   220    /* GC,GU,C,U,G */+   220   220   220   220    /* GC,GU,C,U,U */+    70   250   110   250    /* GC,GU,G,A,A */+    40   210    80   210    /* GC,GU,G,A,C */+   -40   130   130   130    /* GC,GU,G,A,G */+    40   210    80   210    /* GC,GU,G,A,U */+    40   210    80   210    /* GC,GU,G,C,A */+   100   210    80   210    /* GC,GU,G,C,C */+    40   210    80   210    /* GC,GU,G,C,G */+   100   210    80   210    /* GC,GU,G,C,U */+     0   170   170   170    /* GC,GU,G,G,A */+    40   210    80   210    /* GC,GU,G,G,C */+    40    80   210    80    /* GC,GU,G,G,G */+    40   210    80   210    /* GC,GU,G,G,U */+    40   210    80   210    /* GC,GU,G,U,A */+   100   210    80   210    /* GC,GU,G,U,C */+    40   210    80   210    /* GC,GU,G,U,G */+    40   210   210   210    /* GC,GU,G,U,U */+   250   250   250   240    /* GC,GU,U,A,A */+   220   220   220   140    /* GC,GU,U,A,C */+   140   200   140    60    /* GC,GU,U,A,G */+   220   220   220   140    /* GC,GU,U,A,U */+   220   220   220   140    /* GC,GU,U,C,A */+   220   220   220   140    /* GC,GU,U,C,C */+   220   220   220   140    /* GC,GU,U,C,G */+   220   220   220   140    /* GC,GU,U,C,U */+   180   240   180   100    /* GC,GU,U,G,A */+   220   220   220   140    /* GC,GU,U,G,C */+    90    90    90   140    /* GC,GU,U,G,G */+   220   220   220   140    /* GC,GU,U,G,U */+   220   220   220   140    /* GC,GU,U,U,A */+   220   220   220   140    /* GC,GU,U,U,C */+   220   220   220   140    /* GC,GU,U,U,G */+   220   220   220   140    /* GC,GU,U,U,U */+   190   150    40   150    /* GC,UG,A,A,A */+   210   180    70   180    /* GC,UG,A,A,C */+    80    50   -60    50    /* GC,UG,A,A,G */+   210   180    70   180    /* GC,UG,A,A,U */+   210   180    70   180    /* GC,UG,A,C,A */+   210   180   130   180    /* GC,UG,A,C,C */+   210   180    70   180    /* GC,UG,A,C,G */+   210   180   130   180    /* GC,UG,A,C,U */+   240   210   100   210    /* GC,UG,A,G,A */+   210   180    70   180    /* GC,UG,A,G,C */+    80    50    70    50    /* GC,UG,A,G,G */+   210   180    70   180    /* GC,UG,A,G,U */+   210   180    70   180    /* GC,UG,A,U,A */+   210   180   130   180    /* GC,UG,A,U,C */+   210   180    70   180    /* GC,UG,A,U,G */+   270   180    70   180    /* GC,UG,A,U,U */+   150   150   150   160    /* GC,UG,C,A,A */+   190   190   190   190    /* GC,UG,C,A,C */+    50   110    50   120    /* GC,UG,C,A,G */+   190   190   190   190    /* GC,UG,C,A,U */+   190   190   190   190    /* GC,UG,C,C,A */+   190   190   190   190    /* GC,UG,C,C,C */+   190   190   190   190    /* GC,UG,C,C,G */+   190   190   190   190    /* GC,UG,C,C,U */+   220   280   220   280    /* GC,UG,C,G,A */+   190   190   190   190    /* GC,UG,C,G,C */+    60    60    60    60    /* GC,UG,C,G,G */+   190   190   190   190    /* GC,UG,C,G,U */+   190   190   190   190    /* GC,UG,C,U,A */+   190   190   190   190    /* GC,UG,C,U,C */+   190   190   190   190    /* GC,UG,C,U,G */+   190   190   190   190    /* GC,UG,C,U,U */+   -20   150    10   150    /* GC,UG,G,A,A */+    10   180    50   180    /* GC,UG,G,A,C */+  -120    50    40    50    /* GC,UG,G,A,G */+    10   180    50   180    /* GC,UG,G,A,U */+    10   180    50   180    /* GC,UG,G,C,A */+    70   180    50   180    /* GC,UG,G,C,C */+    10   180    50   180    /* GC,UG,G,C,G */+    70   180    50   180    /* GC,UG,G,C,U */+    40   210   210   210    /* GC,UG,G,G,A */+    10   180    50   180    /* GC,UG,G,G,C */+    10    50   180    50    /* GC,UG,G,G,G */+    10   180    50   180    /* GC,UG,G,G,U */+    10   180    50   180    /* GC,UG,G,U,A */+    70   180    50   180    /* GC,UG,G,U,C */+    10   180    50   180    /* GC,UG,G,U,G */+    10   180   180   180    /* GC,UG,G,U,U */+   150   150   150   140    /* GC,UG,U,A,A */+   190   190   190   110    /* GC,UG,U,A,C */+    50   110    50   -20    /* GC,UG,U,A,G */+   190   190   190   110    /* GC,UG,U,A,U */+   190   190   190   110    /* GC,UG,U,C,A */+   190   190   190   110    /* GC,UG,U,C,C */+   190   190   190   110    /* GC,UG,U,C,G */+   190   190   190   110    /* GC,UG,U,C,U */+   220   280   220   140    /* GC,UG,U,G,A */+   190   190   190   110    /* GC,UG,U,G,C */+    60    60    60   110    /* GC,UG,U,G,G */+   190   190   190   110    /* GC,UG,U,G,U */+   190   190   190   110    /* GC,UG,U,U,A */+   190   190   190   110    /* GC,UG,U,U,C */+   190   190   190   110    /* GC,UG,U,U,G */+   190   190   190   110    /* GC,UG,U,U,U */+   210   180    70   180    /* GC,AU,A,A,A */+   190   160    50   160    /* GC,AU,A,A,C */+    90    60   -50    60    /* GC,AU,A,A,G */+   190   160    50   160    /* GC,AU,A,A,U */+   200   170    60   170    /* GC,AU,A,C,A */+   190   160   110   160    /* GC,AU,A,C,C */+   200   170    60   170    /* GC,AU,A,C,G */+   190   160   110   160    /* GC,AU,A,C,U */+   160   130    20   130    /* GC,AU,A,G,A */+   190   160    50   160    /* GC,AU,A,G,C */+    40    10    30    10    /* GC,AU,A,G,G */+   190   160    50   160    /* GC,AU,A,G,U */+   200   170    60   170    /* GC,AU,A,U,A */+   190   160   110   160    /* GC,AU,A,U,C */+   200   170    60   170    /* GC,AU,A,U,G */+   160    70   -30    70    /* GC,AU,A,U,U */+   190   190   190   190    /* GC,AU,C,A,A */+   160   160   160   170    /* GC,AU,C,A,C */+    60   120    60   130    /* GC,AU,C,A,G */+   160   160   160   170    /* GC,AU,C,A,U */+   170   170   170   180    /* GC,AU,C,C,A */+   170   170   170   170    /* GC,AU,C,C,C */+   170   170   170   180    /* GC,AU,C,C,G */+   170   170   170   170    /* GC,AU,C,C,U */+   130   190   130   200    /* GC,AU,C,G,A */+   160   160   160   170    /* GC,AU,C,G,C */+    10    10    10    20    /* GC,AU,C,G,G */+   160   160   160   170    /* GC,AU,C,G,U */+   170   170   170   180    /* GC,AU,C,U,A */+   170   170   170   170    /* GC,AU,C,U,C */+   170   170   170   180    /* GC,AU,C,U,G */+    80    80    80    80    /* GC,AU,C,U,U */+    10   180    50   180    /* GC,AU,G,A,A */+   -10   160    20   160    /* GC,AU,G,A,C */+  -110    60    50    60    /* GC,AU,G,A,G */+   -10   160    20   160    /* GC,AU,G,A,U */+     0   170    30   170    /* GC,AU,G,C,A */+    50   160    30   160    /* GC,AU,G,C,C */+     0   170    30   170    /* GC,AU,G,C,G */+    50   160    30   160    /* GC,AU,G,C,U */+   -40   130   120   130    /* GC,AU,G,G,A */+   -10   160    20   160    /* GC,AU,G,G,C */+   -30    10   130    10    /* GC,AU,G,G,G */+   -10   160    20   160    /* GC,AU,G,G,U */+     0   170    30   170    /* GC,AU,G,U,A */+    50   160    30   160    /* GC,AU,G,U,C */+     0   170    30   170    /* GC,AU,G,U,G */+  -100    70    70    70    /* GC,AU,G,U,U */+   190   190   190   170    /* GC,AU,U,A,A */+   160   160   160    90    /* GC,AU,U,A,C */+    60   120    60   -10    /* GC,AU,U,A,G */+   160   160   160    90    /* GC,AU,U,A,U */+   170   170   170   100    /* GC,AU,U,C,A */+   170   170   170    90    /* GC,AU,U,C,C */+   170   170   170   100    /* GC,AU,U,C,G */+   170   170   170    90    /* GC,AU,U,C,U */+   130   190   130    60    /* GC,AU,U,G,A */+   160   160   160    90    /* GC,AU,U,G,C */+    10    10    10    70    /* GC,AU,U,G,G */+   160   160   160    90    /* GC,AU,U,G,U */+   170   170   170   100    /* GC,AU,U,U,A */+   170   170   170    90    /* GC,AU,U,U,C */+   170   170   170   100    /* GC,AU,U,U,G */+    80    80    80     0    /* GC,AU,U,U,U */+   210   180    70   180    /* GC,UA,A,A,A */+   170   140    30   140    /* GC,UA,A,A,C */+   110    80   -30    80    /* GC,UA,A,A,G */+   170   140    30   140    /* GC,UA,A,A,U */+   210   180    70   180    /* GC,UA,A,C,A */+   210   180   130   180    /* GC,UA,A,C,C */+   210   180    70   180    /* GC,UA,A,C,G */+   210   180   130   180    /* GC,UA,A,C,U */+   120    90   -20    90    /* GC,UA,A,G,A */+   170   140    30   140    /* GC,UA,A,G,C */+    60    30    50    30    /* GC,UA,A,G,G */+   170   140    30   140    /* GC,UA,A,G,U */+   210   180    70   180    /* GC,UA,A,U,A */+   180   150   100   150    /* GC,UA,A,U,C */+   210   180    70   180    /* GC,UA,A,U,G */+   190   100   -10   100    /* GC,UA,A,U,U */+   190   190   190   190    /* GC,UA,C,A,A */+   140   140   140   150    /* GC,UA,C,A,C */+    80   140    80   150    /* GC,UA,C,A,G */+   140   140   140   150    /* GC,UA,C,A,U */+   190   190   190   190    /* GC,UA,C,C,A */+   190   190   190   190    /* GC,UA,C,C,C */+   190   190   190   190    /* GC,UA,C,C,G */+   190   190   190   190    /* GC,UA,C,C,U */+    90   150    90   160    /* GC,UA,C,G,A */+   140   140   140   150    /* GC,UA,C,G,C */+    30    30    30    40    /* GC,UA,C,G,G */+   140   140   140   150    /* GC,UA,C,G,U */+   190   190   190   190    /* GC,UA,C,U,A */+   160   160   160   160    /* GC,UA,C,U,C */+   190   190   190   190    /* GC,UA,C,U,G */+   100   100   100   110    /* GC,UA,C,U,U */+    10   180    50   180    /* GC,UA,G,A,A */+   -30   140     0   140    /* GC,UA,G,A,C */+   -90    80    70    80    /* GC,UA,G,A,G */+   -30   140     0   140    /* GC,UA,G,A,U */+    10   180    50   180    /* GC,UA,G,C,A */+    70   180    50   180    /* GC,UA,G,C,C */+    10   180    50   180    /* GC,UA,G,C,G */+    70   180    50   180    /* GC,UA,G,C,U */+   -80    90    80    90    /* GC,UA,G,G,A */+   -30   140     0   140    /* GC,UA,G,G,C */+   -10    30   150    30    /* GC,UA,G,G,G */+   -30   140     0   140    /* GC,UA,G,G,U */+    10   180    50   180    /* GC,UA,G,U,A */+    40   150    20   150    /* GC,UA,G,U,C */+    10   180    50   180    /* GC,UA,G,U,G */+   -70   100    90   100    /* GC,UA,G,U,U */+   190   190   190   170    /* GC,UA,U,A,A */+   140   140   140    70    /* GC,UA,U,A,C */+    80   140    80    10    /* GC,UA,U,A,G */+   140   140   140    70    /* GC,UA,U,A,U */+   190   190   190   110    /* GC,UA,U,C,A */+   190   190   190   110    /* GC,UA,U,C,C */+   190   190   190   110    /* GC,UA,U,C,G */+   190   190   190   110    /* GC,UA,U,C,U */+    90   150    90    20    /* GC,UA,U,G,A */+   140   140   140    70    /* GC,UA,U,G,C */+    30    30    30    90    /* GC,UA,U,G,G */+   140   140   140    70    /* GC,UA,U,G,U */+   190   190   190   110    /* GC,UA,U,U,A */+   160   160   160    80    /* GC,UA,U,U,C */+   190   190   190   110    /* GC,UA,U,U,G */+   100   100   100    30    /* GC,UA,U,U,U */+   270   230   190   230    /* GU,CG,A,A,A */+   260   220   180   220    /* GU,CG,A,A,C */+   170   130    90   130    /* GU,CG,A,A,G */+   260   220   180   220    /* GU,CG,A,A,U */+   300   270   230   270    /* GU,CG,A,C,A */+   290   250   270   250    /* GU,CG,A,C,C */+   300   270   230   270    /* GU,CG,A,C,G */+   270   240   260   240    /* GU,CG,A,C,U */+   170   130    90   130    /* GU,CG,A,G,A */+   260   220   180   220    /* GU,CG,A,G,C */+   110    80   170    80    /* GU,CG,A,G,G */+   260   220   180   220    /* GU,CG,A,G,U */+   300   270   230   270    /* GU,CG,A,U,A */+   270   240   260   240    /* GU,CG,A,U,C */+   300   270   230   270    /* GU,CG,A,U,G */+   240   150   110   150    /* GU,CG,A,U,U */+   230   230   230   230    /* GU,CG,C,A,A */+   220   220   220   220    /* GU,CG,C,A,C */+   130   190   130   190    /* GU,CG,C,A,G */+   220   220   220   220    /* GU,CG,C,A,U */+   270   270   270   270    /* GU,CG,C,C,A */+   250   250   250   250    /* GU,CG,C,C,C */+   270   270   270   270    /* GU,CG,C,C,G */+   240   240   240   240    /* GU,CG,C,C,U */+   130   190   130   190    /* GU,CG,C,G,A */+   220   220   220   220    /* GU,CG,C,G,C */+    80    80    80    80    /* GU,CG,C,G,G */+   220   220   220   220    /* GU,CG,C,G,U */+   270   270   270   270    /* GU,CG,C,U,A */+   240   240   240   240    /* GU,CG,C,U,C */+   270   270   270   270    /* GU,CG,C,U,G */+   150   150   150   150    /* GU,CG,C,U,U */+   150   230   100   230    /* GU,CG,G,A,A */+   140   220    90   220    /* GU,CG,G,A,C */+    50   130   130   130    /* GU,CG,G,A,G */+   140   220    90   220    /* GU,CG,G,A,U */+   190   270   140   270    /* GU,CG,G,C,A */+   230   250   120   250    /* GU,CG,G,C,C */+   190   270   140   270    /* GU,CG,G,C,G */+   220   240   110   240    /* GU,CG,G,C,U */+    50   130   130   130    /* GU,CG,G,G,A */+   140   220    90   220    /* GU,CG,G,G,C */+   130    80   210    80    /* GU,CG,G,G,G */+   140   220    90   220    /* GU,CG,G,G,U */+   190   270   140   270    /* GU,CG,G,U,A */+   220   240   110   240    /* GU,CG,G,U,C */+   190   270   140   270    /* GU,CG,G,U,G */+    70   150   150   150    /* GU,CG,G,U,U */+   230   230   230   290    /* GU,CG,U,A,A */+   220   220   220   220    /* GU,CG,U,A,C */+   130   190   130   130    /* GU,CG,U,A,G */+   220   220   220   220    /* GU,CG,U,A,U */+   270   270   270   270    /* GU,CG,U,C,A */+   250   250   250   250    /* GU,CG,U,C,C */+   270   270   270   270    /* GU,CG,U,C,G */+   240   240   240   240    /* GU,CG,U,C,U */+   130   190   130   130    /* GU,CG,U,G,A */+   220   220   220   220    /* GU,CG,U,G,C */+    80    80    80   210    /* GU,CG,U,G,G */+   220   220   220   220    /* GU,CG,U,G,U */+   270   270   270   270    /* GU,CG,U,U,A */+   240   240   240   240    /* GU,CG,U,U,C */+   270   270   270   270    /* GU,CG,U,U,G */+   150   150   150   150    /* GU,CG,U,U,U */+   280   240   200   240    /* GU,GC,A,A,A */+   250   220   180   220    /* GU,GC,A,A,C */+    70    40     0    40    /* GU,GC,A,A,G */+   250   220   180   220    /* GU,GC,A,A,U */+   250   210   170   210    /* GU,GC,A,C,A */+   250   220   240   220    /* GU,GC,A,C,C */+   250   210   170   210    /* GU,GC,A,C,G */+   250   220   240   220    /* GU,GC,A,C,U */+   140   100    60   100    /* GU,GC,A,G,A */+   250   220   180   220    /* GU,GC,A,G,C */+   110    80   170    80    /* GU,GC,A,G,G */+   250   220   180   220    /* GU,GC,A,G,U */+   250   210   170   210    /* GU,GC,A,U,A */+   260   220   240   220    /* GU,GC,A,U,C */+   250   210   170   210    /* GU,GC,A,U,G */+   240   140   100   140    /* GU,GC,A,U,U */+   240   240   240   240    /* GU,GC,C,A,A */+   220   220   220   220    /* GU,GC,C,A,C */+    40   100    40   100    /* GU,GC,C,A,G */+   220   220   220   220    /* GU,GC,C,A,U */+   210   210   210   210    /* GU,GC,C,C,A */+   220   220   220   220    /* GU,GC,C,C,C */+   210   210   210   210    /* GU,GC,C,C,G */+   220   220   220   220    /* GU,GC,C,C,U */+   100   160   100   160    /* GU,GC,C,G,A */+   220   220   220   220    /* GU,GC,C,G,C */+    80    80    80    80    /* GU,GC,C,G,G */+   220   220   220   220    /* GU,GC,C,G,U */+   210   210   210   210    /* GU,GC,C,U,A */+   220   220   220   220    /* GU,GC,C,U,C */+   210   210   210   210    /* GU,GC,C,U,G */+   140   140   140   140    /* GU,GC,C,U,U */+   160   240   110   240    /* GU,GC,G,A,A */+   140   220    90   220    /* GU,GC,G,A,C */+   -40    40    40    40    /* GU,GC,G,A,G */+   140   220    90   220    /* GU,GC,G,A,U */+   130   210    80   210    /* GU,GC,G,C,A */+   200   220    90   220    /* GU,GC,G,C,C */+   130   210    80   210    /* GU,GC,G,C,G */+   200   220    90   220    /* GU,GC,G,C,U */+    20   100   100   100    /* GU,GC,G,G,A */+   140   220    90   220    /* GU,GC,G,G,C */+   130    80   210    80    /* GU,GC,G,G,G */+   140   220    90   220    /* GU,GC,G,G,U */+   130   210    80   210    /* GU,GC,G,U,A */+   200   220    90   220    /* GU,GC,G,U,C */+   130   210    80   210    /* GU,GC,G,U,G */+    60   140   140   140    /* GU,GC,G,U,U */+   240   240   240   300    /* GU,GC,U,A,A */+   220   220   220   220    /* GU,GC,U,A,C */+    40   100    40    40    /* GU,GC,U,A,G */+   220   220   220   220    /* GU,GC,U,A,U */+   210   210   210   210    /* GU,GC,U,C,A */+   220   220   220   220    /* GU,GC,U,C,C */+   210   210   210   210    /* GU,GC,U,C,G */+   220   220   220   220    /* GU,GC,U,C,U */+   100   160   100   100    /* GU,GC,U,G,A */+   220   220   220   220    /* GU,GC,U,G,C */+    80    80    80   210    /* GU,GC,U,G,G */+   220   220   220   220    /* GU,GC,U,G,U */+   210   210   210   210    /* GU,GC,U,U,A */+   220   220   220   220    /* GU,GC,U,U,C */+   210   210   210   210    /* GU,GC,U,U,G */+   140   140   140   140    /* GU,GC,U,U,U */+   410   370   330   370    /* GU,GU,A,A,A */+   370   340   300   340    /* GU,GU,A,A,C */+   290   260   220   260    /* GU,GU,A,A,G */+   370   340   300   340    /* GU,GU,A,A,U */+   370   340   300   340    /* GU,GU,A,C,A */+   370   340   360   340    /* GU,GU,A,C,C */+   370   340   300   340    /* GU,GU,A,C,G */+   370   340   360   340    /* GU,GU,A,C,U */+   330   300   260   300    /* GU,GU,A,G,A */+   370   340   300   340    /* GU,GU,A,G,C */+   240   210   300   210    /* GU,GU,A,G,G */+   370   340   300   340    /* GU,GU,A,G,U */+   370   340   300   340    /* GU,GU,A,U,A */+   370   340   360   340    /* GU,GU,A,U,C */+   370   340   300   340    /* GU,GU,A,U,G */+   430   340   300   340    /* GU,GU,A,U,U */+   370   370   370   370    /* GU,GU,C,A,A */+   340   340   340   340    /* GU,GU,C,A,C */+   260   320   260   320    /* GU,GU,C,A,G */+   340   340   340   340    /* GU,GU,C,A,U */+   340   340   340   340    /* GU,GU,C,C,A */+   340   340   340   340    /* GU,GU,C,C,C */+   340   340   340   340    /* GU,GU,C,C,G */+   340   340   340   340    /* GU,GU,C,C,U */+   300   360   300   360    /* GU,GU,C,G,A */+   340   340   340   340    /* GU,GU,C,G,C */+   210   210   210   210    /* GU,GU,C,G,G */+   340   340   340   340    /* GU,GU,C,G,U */+   340   340   340   340    /* GU,GU,C,U,A */+   340   340   340   340    /* GU,GU,C,U,C */+   340   340   340   340    /* GU,GU,C,U,G */+   340   340   340   340    /* GU,GU,C,U,U */+   290   370   240   370    /* GU,GU,G,A,A */+   260   340   210   340    /* GU,GU,G,A,C */+   180   260   260   260    /* GU,GU,G,A,G */+   260   340   210   340    /* GU,GU,G,A,U */+   260   340   210   340    /* GU,GU,G,C,A */+   320   340   210   340    /* GU,GU,G,C,C */+   260   340   210   340    /* GU,GU,G,C,G */+   320   340   210   340    /* GU,GU,G,C,U */+   220   300   300   300    /* GU,GU,G,G,A */+   260   340   210   340    /* GU,GU,G,G,C */+   260   210   340   210    /* GU,GU,G,G,G */+   260   340   210   340    /* GU,GU,G,G,U */+   260   340   210   340    /* GU,GU,G,U,A */+   320   340   210   340    /* GU,GU,G,U,C */+   260   340   210   340    /* GU,GU,G,U,G */+   260   340   340   340    /* GU,GU,G,U,U */+   370   370   370   430    /* GU,GU,U,A,A */+   340   340   340   340    /* GU,GU,U,A,C */+   260   320   260   260    /* GU,GU,U,A,G */+   340   340   340   340    /* GU,GU,U,A,U */+   340   340   340   340    /* GU,GU,U,C,A */+   340   340   340   340    /* GU,GU,U,C,C */+   340   340   340   340    /* GU,GU,U,C,G */+   340   340   340   340    /* GU,GU,U,C,U */+   300   360   300   300    /* GU,GU,U,G,A */+   340   340   340   340    /* GU,GU,U,G,C */+   210   210   210   340    /* GU,GU,U,G,G */+   340   340   340   340    /* GU,GU,U,G,U */+   340   340   340   340    /* GU,GU,U,U,A */+   340   340   340   340    /* GU,GU,U,U,C */+   340   340   340   340    /* GU,GU,U,U,G */+   340   340   340   340    /* GU,GU,U,U,U */+   360   270   360   270    /* GU,UG,A,A,A */+   340   310   270   310    /* GU,UG,A,A,C */+   220   170   130   170    /* GU,UG,A,A,G */+   340   310   270   310    /* GU,UG,A,A,U */+   340   310   270   310    /* GU,UG,A,C,A */+   340   310   330   310    /* GU,UG,A,C,C */+   340   310   270   310    /* GU,UG,A,C,G */+   340   310   330   310    /* GU,UG,A,C,U */+   370   340   300   340    /* GU,UG,A,G,A */+   340   310   270   310    /* GU,UG,A,G,C */+   210   180   270   180    /* GU,UG,A,G,G */+   340   310   270   310    /* GU,UG,A,G,U */+   340   310   270   310    /* GU,UG,A,U,A */+   340   310   330   310    /* GU,UG,A,U,C */+   340   310   270   310    /* GU,UG,A,U,G */+   400   310   270   310    /* GU,UG,A,U,U */+   270   270   270   270    /* GU,UG,C,A,A */+   310   310   310   310    /* GU,UG,C,A,C */+   170   230   170   230    /* GU,UG,C,A,G */+   310   310   310   310    /* GU,UG,C,A,U */+   310   310   310   310    /* GU,UG,C,C,A */+   310   310   310   310    /* GU,UG,C,C,C */+   310   310   310   310    /* GU,UG,C,C,G */+   310   310   310   310    /* GU,UG,C,C,U */+   340   400   340   400    /* GU,UG,C,G,A */+   310   310   310   310    /* GU,UG,C,G,C */+   180   180   180   180    /* GU,UG,C,G,G */+   310   310   310   310    /* GU,UG,C,G,U */+   310   310   310   310    /* GU,UG,C,U,A */+   310   310   310   310    /* GU,UG,C,U,C */+   310   310   310   310    /* GU,UG,C,U,G */+   310   310   310   310    /* GU,UG,C,U,U */+   190   270   140   270    /* GU,UG,G,A,A */+   230   310   180   310    /* GU,UG,G,A,C */+    20   170   170   170    /* GU,UG,G,A,G */+   230   310   180   310    /* GU,UG,G,A,U */+   230   310   180   310    /* GU,UG,G,C,A */+   290   310   180   310    /* GU,UG,G,C,C */+   230   310   180   310    /* GU,UG,G,C,G */+   290   310   180   310    /* GU,UG,G,C,U */+   260   340   340   340    /* GU,UG,G,G,A */+   230   310   180   310    /* GU,UG,G,G,C */+   230   180   310   180    /* GU,UG,G,G,G */+   230   310   180   310    /* GU,UG,G,G,U */+   230   310   180   310    /* GU,UG,G,U,A */+   290   310   180   310    /* GU,UG,G,U,C */+   230   310   180   310    /* GU,UG,G,U,G */+   230   310   310   310    /* GU,UG,G,U,U */+   270   270   270   330    /* GU,UG,U,A,A */+   310   310   310   310    /* GU,UG,U,A,C */+   170   230   170   170    /* GU,UG,U,A,G */+   310   310   310   310    /* GU,UG,U,A,U */+   310   310   310   310    /* GU,UG,U,C,A */+   310   310   310   310    /* GU,UG,U,C,C */+   310   310   310   310    /* GU,UG,U,C,G */+   310   310   310   310    /* GU,UG,U,C,U */+   340   400   340   340    /* GU,UG,U,G,A */+   310   310   310   310    /* GU,UG,U,G,C */+   180   180   180   310    /* GU,UG,U,G,G */+   310   310   310   310    /* GU,UG,U,G,U */+   310   310   310   310    /* GU,UG,U,U,A */+   310   310   310   310    /* GU,UG,U,U,C */+   310   310   310   310    /* GU,UG,U,U,G */+   310   310   310   310    /* GU,UG,U,U,U */+   340   310   270   310    /* GU,AU,A,A,A */+   320   280   240   280    /* GU,AU,A,A,C */+   220   180   140   180    /* GU,AU,A,A,G */+   320   280   240   280    /* GU,AU,A,A,U */+   330   290   250   290    /* GU,AU,A,C,A */+   320   290   310   290    /* GU,AU,A,C,C */+   330   290   250   290    /* GU,AU,A,C,G */+   320   290   310   290    /* GU,AU,A,C,U */+   290   250   210   250    /* GU,AU,A,G,A */+   320   280   240   280    /* GU,AU,A,G,C */+   170   130   220   130    /* GU,AU,A,G,G */+   320   280   240   280    /* GU,AU,A,G,U */+   330   290   250   290    /* GU,AU,A,U,A */+   320   290   310   290    /* GU,AU,A,U,C */+   330   290   250   290    /* GU,AU,A,U,G */+   290   200   160   200    /* GU,AU,A,U,U */+   310   310   310   310    /* GU,AU,C,A,A */+   280   280   280   280    /* GU,AU,C,A,C */+   180   240   180   240    /* GU,AU,C,A,G */+   280   280   280   280    /* GU,AU,C,A,U */+   290   290   290   290    /* GU,AU,C,C,A */+   290   290   290   290    /* GU,AU,C,C,C */+   290   290   290   290    /* GU,AU,C,C,G */+   290   290   290   290    /* GU,AU,C,C,U */+   250   310   250   310    /* GU,AU,C,G,A */+   280   280   280   280    /* GU,AU,C,G,C */+   130   130   130   130    /* GU,AU,C,G,G */+   280   280   280   280    /* GU,AU,C,G,U */+   290   290   290   290    /* GU,AU,C,U,A */+   290   290   290   290    /* GU,AU,C,U,C */+   290   290   290   290    /* GU,AU,C,U,G */+   200   200   200   200    /* GU,AU,C,U,U */+   230   310   180   310    /* GU,AU,G,A,A */+   200   280   150   280    /* GU,AU,G,A,C */+   100   180   180   180    /* GU,AU,G,A,G */+   200   280   150   280    /* GU,AU,G,A,U */+   210   290   160   290    /* GU,AU,G,C,A */+   270   290   160   290    /* GU,AU,G,C,C */+   210   290   160   290    /* GU,AU,G,C,G */+   270   290   160   290    /* GU,AU,G,C,U */+   170   250   250   250    /* GU,AU,G,G,A */+   200   280   150   280    /* GU,AU,G,G,C */+   180   130   260   130    /* GU,AU,G,G,G */+   200   280   150   280    /* GU,AU,G,G,U */+   210   290   160   290    /* GU,AU,G,U,A */+   270   290   160   290    /* GU,AU,G,U,C */+   210   290   160   290    /* GU,AU,G,U,G */+   120   200   200   200    /* GU,AU,G,U,U */+   310   310   310   370    /* GU,AU,U,A,A */+   280   280   280   280    /* GU,AU,U,A,C */+   180   240   180   180    /* GU,AU,U,A,G */+   280   280   280   280    /* GU,AU,U,A,U */+   290   290   290   290    /* GU,AU,U,C,A */+   290   290   290   290    /* GU,AU,U,C,C */+   290   290   290   290    /* GU,AU,U,C,G */+   290   290   290   290    /* GU,AU,U,C,U */+   250   310   250   250    /* GU,AU,U,G,A */+   280   280   280   280    /* GU,AU,U,G,C */+   130   130   130   260    /* GU,AU,U,G,G */+   280   280   280   280    /* GU,AU,U,G,U */+   290   290   290   290    /* GU,AU,U,U,A */+   290   290   290   290    /* GU,AU,U,U,C */+   290   290   290   290    /* GU,AU,U,U,G */+   200   200   200   200    /* GU,AU,U,U,U */+   340   310   270   310    /* GU,UA,A,A,A */+   300   260   220   260    /* GU,UA,A,A,C */+   240   200   160   200    /* GU,UA,A,A,G */+   300   260   220   260    /* GU,UA,A,A,U */+   340   310   270   310    /* GU,UA,A,C,A */+   340   310   330   310    /* GU,UA,A,C,C */+   340   310   270   310    /* GU,UA,A,C,G */+   340   310   330   310    /* GU,UA,A,C,U */+   250   210   170   210    /* GU,UA,A,G,A */+   300   260   220   260    /* GU,UA,A,G,C */+   190   150   240   150    /* GU,UA,A,G,G */+   300   260   220   260    /* GU,UA,A,G,U */+   340   310   270   310    /* GU,UA,A,U,A */+   310   280   300   280    /* GU,UA,A,U,C */+   340   310   270   310    /* GU,UA,A,U,G */+   320   220   180   220    /* GU,UA,A,U,U */+   310   310   310   310    /* GU,UA,C,A,A */+   260   260   260   260    /* GU,UA,C,A,C */+   200   260   200   260    /* GU,UA,C,A,G */+   260   260   260   260    /* GU,UA,C,A,U */+   310   310   310   310    /* GU,UA,C,C,A */+   310   310   310   310    /* GU,UA,C,C,C */+   310   310   310   310    /* GU,UA,C,C,G */+   310   310   310   310    /* GU,UA,C,C,U */+   210   270   210   270    /* GU,UA,C,G,A */+   260   260   260   260    /* GU,UA,C,G,C */+   150   150   150   150    /* GU,UA,C,G,G */+   260   260   260   260    /* GU,UA,C,G,U */+   310   310   310   310    /* GU,UA,C,U,A */+   280   280   280   280    /* GU,UA,C,U,C */+   310   310   310   310    /* GU,UA,C,U,G */+   220   220   220   220    /* GU,UA,C,U,U */+   230   310   180   310    /* GU,UA,G,A,A */+   180   260   130   260    /* GU,UA,G,A,C */+   120   200   200   200    /* GU,UA,G,A,G */+   180   260   130   260    /* GU,UA,G,A,U */+   230   310   180   310    /* GU,UA,G,C,A */+   290   310   180   310    /* GU,UA,G,C,C */+   230   310   180   310    /* GU,UA,G,C,G */+   290   310   180   310    /* GU,UA,G,C,U */+   130   210   210   210    /* GU,UA,G,G,A */+   180   260   130   260    /* GU,UA,G,G,C */+   200   150   280   150    /* GU,UA,G,G,G */+   180   260   130   260    /* GU,UA,G,G,U */+   230   310   180   310    /* GU,UA,G,U,A */+   260   280   150   280    /* GU,UA,G,U,C */+   230   310   180   310    /* GU,UA,G,U,G */+   140   220   220   220    /* GU,UA,G,U,U */+   310   310   310   370    /* GU,UA,U,A,A */+   260   260   260   260    /* GU,UA,U,A,C */+   200   260   200   200    /* GU,UA,U,A,G */+   260   260   260   260    /* GU,UA,U,A,U */+   310   310   310   310    /* GU,UA,U,C,A */+   310   310   310   310    /* GU,UA,U,C,C */+   310   310   310   310    /* GU,UA,U,C,G */+   310   310   310   310    /* GU,UA,U,C,U */+   210   270   210   210    /* GU,UA,U,G,A */+   260   260   260   260    /* GU,UA,U,G,C */+   150   150   150   280    /* GU,UA,U,G,G */+   260   260   260   260    /* GU,UA,U,G,U */+   310   310   310   310    /* GU,UA,U,U,A */+   280   280   280   280    /* GU,UA,U,U,C */+   310   310   310   310    /* GU,UA,U,U,G */+   220   220   220   220    /* GU,UA,U,U,U */+   160   200   230   200    /* UG,CG,A,A,A */+   160   190   220   190    /* UG,CG,A,A,C */+    70   100   130   100    /* UG,CG,A,A,G */+   160   190   220   190    /* UG,CG,A,A,U */+   200   240   270   240    /* UG,CG,A,C,A */+   190   220   310   220    /* UG,CG,A,C,C */+   200   240   270   240    /* UG,CG,A,C,G */+   170   210   300   210    /* UG,CG,A,C,U */+    70   100   130   100    /* UG,CG,A,G,A */+   160   190   220   190    /* UG,CG,A,G,C */+    10    50   210    50    /* UG,CG,A,G,G */+   160   190   220   190    /* UG,CG,A,G,U */+   200   240   270   240    /* UG,CG,A,U,A */+   170   210   300   210    /* UG,CG,A,U,C */+   200   240   270   240    /* UG,CG,A,U,G */+   140   120   150   120    /* UG,CG,A,U,U */+   200   200   200   200    /* UG,CG,C,A,A */+   190   190   190   190    /* UG,CG,C,A,C */+   100   160   100   160    /* UG,CG,C,A,G */+   190   190   190   190    /* UG,CG,C,A,U */+   240   240   240   240    /* UG,CG,C,C,A */+   220   220   220   220    /* UG,CG,C,C,C */+   240   240   240   240    /* UG,CG,C,C,G */+   210   210   210   210    /* UG,CG,C,C,U */+   100   160   100   160    /* UG,CG,C,G,A */+   190   190   190   190    /* UG,CG,C,G,C */+    50    50    50    50    /* UG,CG,C,G,G */+   190   190   190   190    /* UG,CG,C,G,U */+   240   240   240   240    /* UG,CG,C,U,A */+   210   210   210   210    /* UG,CG,C,U,C */+   240   240   240   240    /* UG,CG,C,U,G */+   120   120   120   120    /* UG,CG,C,U,U */+    60   200    70   200    /* UG,CG,G,A,A */+    60   190    60   190    /* UG,CG,G,A,C */+   -30   100   100   100    /* UG,CG,G,A,G */+    60   190    60   190    /* UG,CG,G,A,U */+   100   240   110   240    /* UG,CG,G,C,A */+   150   220    90   220    /* UG,CG,G,C,C */+   100   240   110   240    /* UG,CG,G,C,G */+   130   210    80   210    /* UG,CG,G,C,U */+   -30   100   100   100    /* UG,CG,G,G,A */+    60   190    60   190    /* UG,CG,G,G,C */+    40    50   180    50    /* UG,CG,G,G,G */+    60   190    60   190    /* UG,CG,G,G,U */+   100   240   110   240    /* UG,CG,G,U,A */+   130   210    80   210    /* UG,CG,G,U,C */+   100   240   110   240    /* UG,CG,G,U,G */+   -10   120   120   120    /* UG,CG,G,U,U */+   200   200   200   260    /* UG,CG,U,A,A */+   190   190   190   190    /* UG,CG,U,A,C */+   100   160   100   100    /* UG,CG,U,A,G */+   190   190   190   190    /* UG,CG,U,A,U */+   240   240   240   240    /* UG,CG,U,C,A */+   220   220   220   220    /* UG,CG,U,C,C */+   240   240   240   240    /* UG,CG,U,C,G */+   210   210   210   210    /* UG,CG,U,C,U */+   100   160   100   100    /* UG,CG,U,G,A */+   190   190   190   190    /* UG,CG,U,G,C */+    50    50    50   180    /* UG,CG,U,G,G */+   190   190   190   190    /* UG,CG,U,G,U */+   240   240   240   240    /* UG,CG,U,U,A */+   210   210   210   210    /* UG,CG,U,U,C */+   240   240   240   240    /* UG,CG,U,U,G */+   120   120   120   120    /* UG,CG,U,U,U */+   190   210   240   210    /* UG,GC,A,A,A */+   150   190   220   190    /* UG,GC,A,A,C */+   -20    10    40    10    /* UG,GC,A,A,G */+   150   190   220   190    /* UG,GC,A,A,U */+   150   180   210   180    /* UG,GC,A,C,A */+   150   190   280   190    /* UG,GC,A,C,C */+   150   180   210   180    /* UG,GC,A,C,G */+   150   190   280   190    /* UG,GC,A,C,U */+    40    70   100    70    /* UG,GC,A,G,A */+   150   190   220   190    /* UG,GC,A,G,C */+    10    50   210    50    /* UG,GC,A,G,G */+   150   190   220   190    /* UG,GC,A,G,U */+   150   180   210   180    /* UG,GC,A,U,A */+   160   190   280   190    /* UG,GC,A,U,C */+   150   180   210   180    /* UG,GC,A,U,G */+   140   110   140   110    /* UG,GC,A,U,U */+   210   210   210   210    /* UG,GC,C,A,A */+   190   190   190   190    /* UG,GC,C,A,C */+    10    70    10    70    /* UG,GC,C,A,G */+   190   190   190   190    /* UG,GC,C,A,U */+   180   180   180   180    /* UG,GC,C,C,A */+   190   190   190   190    /* UG,GC,C,C,C */+   180   180   180   180    /* UG,GC,C,C,G */+   190   190   190   190    /* UG,GC,C,C,U */+    70   130    70   130    /* UG,GC,C,G,A */+   190   190   190   190    /* UG,GC,C,G,C */+    50    50    50    50    /* UG,GC,C,G,G */+   190   190   190   190    /* UG,GC,C,G,U */+   180   180   180   180    /* UG,GC,C,U,A */+   190   190   190   190    /* UG,GC,C,U,C */+   180   180   180   180    /* UG,GC,C,U,G */+   110   110   110   110    /* UG,GC,C,U,U */+    80   210    80   210    /* UG,GC,G,A,A */+    50   190    60   190    /* UG,GC,G,A,C */+  -120    10    10    10    /* UG,GC,G,A,G */+    50   190    60   190    /* UG,GC,G,A,U */+    50   180    50   180    /* UG,GC,G,C,A */+   110   190    60   190    /* UG,GC,G,C,C */+    50   180    50   180    /* UG,GC,G,C,G */+   110   190    60   190    /* UG,GC,G,C,U */+   -60    70    70    70    /* UG,GC,G,G,A */+    50   190    60   190    /* UG,GC,G,G,C */+    40    50   180    50    /* UG,GC,G,G,G */+    50   190    60   190    /* UG,GC,G,G,U */+    50   180    50   180    /* UG,GC,G,U,A */+   120   190    60   190    /* UG,GC,G,U,C */+    50   180    50   180    /* UG,GC,G,U,G */+   -20   110   110   110    /* UG,GC,G,U,U */+   210   210   210   270    /* UG,GC,U,A,A */+   190   190   190   190    /* UG,GC,U,A,C */+    10    70    10    10    /* UG,GC,U,A,G */+   190   190   190   190    /* UG,GC,U,A,U */+   180   180   180   180    /* UG,GC,U,C,A */+   190   190   190   190    /* UG,GC,U,C,C */+   180   180   180   180    /* UG,GC,U,C,G */+   190   190   190   190    /* UG,GC,U,C,U */+    70   130    70    70    /* UG,GC,U,G,A */+   190   190   190   190    /* UG,GC,U,G,C */+    50    50    50   180    /* UG,GC,U,G,G */+   190   190   190   190    /* UG,GC,U,G,U */+   180   180   180   180    /* UG,GC,U,U,A */+   190   190   190   190    /* UG,GC,U,U,C */+   180   180   180   180    /* UG,GC,U,U,G */+   110   110   110   110    /* UG,GC,U,U,U */+   360   340   370   340    /* UG,GU,A,A,A */+   270   310   340   310    /* UG,GU,A,A,C */+   190   230   260   230    /* UG,GU,A,A,G */+   270   310   340   310    /* UG,GU,A,A,U */+   270   310   340   310    /* UG,GU,A,C,A */+   270   310   400   310    /* UG,GU,A,C,C */+   270   310   340   310    /* UG,GU,A,C,G */+   270   310   400   310    /* UG,GU,A,C,U */+   360   270   300   270    /* UG,GU,A,G,A */+   270   310   340   310    /* UG,GU,A,G,C */+   140   180   340   180    /* UG,GU,A,G,G */+   270   310   340   310    /* UG,GU,A,G,U */+   270   310   340   310    /* UG,GU,A,U,A */+   270   310   400   310    /* UG,GU,A,U,C */+   270   310   340   310    /* UG,GU,A,U,G */+   330   310   340   310    /* UG,GU,A,U,U */+   340   340   340   340    /* UG,GU,C,A,A */+   310   310   310   310    /* UG,GU,C,A,C */+   230   290   230   290    /* UG,GU,C,A,G */+   310   310   310   310    /* UG,GU,C,A,U */+   310   310   310   310    /* UG,GU,C,C,A */+   310   310   310   310    /* UG,GU,C,C,C */+   310   310   310   310    /* UG,GU,C,C,G */+   310   310   310   310    /* UG,GU,C,C,U */+   270   330   270   330    /* UG,GU,C,G,A */+   310   310   310   310    /* UG,GU,C,G,C */+   180   180   180   180    /* UG,GU,C,G,G */+   310   310   310   310    /* UG,GU,C,G,U */+   310   310   310   310    /* UG,GU,C,U,A */+   310   310   310   310    /* UG,GU,C,U,C */+   310   310   310   310    /* UG,GU,C,U,G */+   310   310   310   310    /* UG,GU,C,U,U */+   220   340   210   340    /* UG,GU,G,A,A */+   170   310   180   310    /* UG,GU,G,A,C */+    20   230   230   230    /* UG,GU,G,A,G */+   170   310   180   310    /* UG,GU,G,A,U */+   170   310   180   310    /* UG,GU,G,C,A */+   230   310   180   310    /* UG,GU,G,C,C */+   170   310   180   310    /* UG,GU,G,C,G */+   230   310   180   310    /* UG,GU,G,C,U */+   130   270   270   270    /* UG,GU,G,G,A */+   170   310   180   310    /* UG,GU,G,G,C */+   170   180   310   180    /* UG,GU,G,G,G */+   170   310   180   310    /* UG,GU,G,G,U */+   170   310   180   310    /* UG,GU,G,U,A */+   230   310   180   310    /* UG,GU,G,U,C */+   170   310   180   310    /* UG,GU,G,U,G */+   170   310   310   310    /* UG,GU,G,U,U */+   340   340   340   400    /* UG,GU,U,A,A */+   310   310   310   310    /* UG,GU,U,A,C */+   230   290   230   230    /* UG,GU,U,A,G */+   310   310   310   310    /* UG,GU,U,A,U */+   310   310   310   310    /* UG,GU,U,C,A */+   310   310   310   310    /* UG,GU,U,C,C */+   310   310   310   310    /* UG,GU,U,C,G */+   310   310   310   310    /* UG,GU,U,C,U */+   270   330   270   270    /* UG,GU,U,G,A */+   310   310   310   310    /* UG,GU,U,G,C */+   180   180   180   310    /* UG,GU,U,G,G */+   310   310   310   310    /* UG,GU,U,G,U */+   310   310   310   310    /* UG,GU,U,U,A */+   310   310   310   310    /* UG,GU,U,U,C */+   310   310   310   310    /* UG,GU,U,U,G */+   310   310   310   310    /* UG,GU,U,U,U */+   210   240   270   240    /* UG,UG,A,A,A */+   240   280   310   280    /* UG,UG,A,A,C */+   110   140   170   140    /* UG,UG,A,A,G */+   240   280   310   280    /* UG,UG,A,A,U */+   240   280   310   280    /* UG,UG,A,C,A */+   240   280   370   280    /* UG,UG,A,C,C */+   240   280   310   280    /* UG,UG,A,C,G */+   240   280   370   280    /* UG,UG,A,C,U */+   270   310   340   310    /* UG,UG,A,G,A */+   240   280   310   280    /* UG,UG,A,G,C */+   110   150   310   150    /* UG,UG,A,G,G */+   240   280   310   280    /* UG,UG,A,G,U */+   240   280   310   280    /* UG,UG,A,U,A */+   240   280   370   280    /* UG,UG,A,U,C */+   240   280   310   280    /* UG,UG,A,U,G */+   300   280   310   280    /* UG,UG,A,U,U */+   240   240   240   240    /* UG,UG,C,A,A */+   280   280   280   280    /* UG,UG,C,A,C */+   140   200   140   200    /* UG,UG,C,A,G */+   280   280   280   280    /* UG,UG,C,A,U */+   280   280   280   280    /* UG,UG,C,C,A */+   280   280   280   280    /* UG,UG,C,C,C */+   280   280   280   280    /* UG,UG,C,C,G */+   280   280   280   280    /* UG,UG,C,C,U */+   310   370   310   370    /* UG,UG,C,G,A */+   280   280   280   280    /* UG,UG,C,G,C */+   150   150   150   150    /* UG,UG,C,G,G */+   280   280   280   280    /* UG,UG,C,G,U */+   280   280   280   280    /* UG,UG,C,U,A */+   280   280   280   280    /* UG,UG,C,U,C */+   280   280   280   280    /* UG,UG,C,U,G */+   280   280   280   280    /* UG,UG,C,U,U */+   110   240   110   240    /* UG,UG,G,A,A */+   140   280   150   280    /* UG,UG,G,A,C */+    10   140   140   140    /* UG,UG,G,A,G */+   140   280   150   280    /* UG,UG,G,A,U */+   140   280   150   280    /* UG,UG,G,C,A */+   200   280   150   280    /* UG,UG,G,C,C */+   140   280   150   280    /* UG,UG,G,C,G */+   200   280   150   280    /* UG,UG,G,C,U */+   170   310   310   310    /* UG,UG,G,G,A */+   140   280   150   280    /* UG,UG,G,G,C */+   140   150   280   150    /* UG,UG,G,G,G */+   140   280   150   280    /* UG,UG,G,G,U */+   140   280   150   280    /* UG,UG,G,U,A */+   200   280   150   280    /* UG,UG,G,U,C */+   140   280   150   280    /* UG,UG,G,U,G */+   140   280   280   280    /* UG,UG,G,U,U */+   240   240   240   300    /* UG,UG,U,A,A */+   280   280   280   280    /* UG,UG,U,A,C */+   140   200   140   140    /* UG,UG,U,A,G */+   280   280   280   280    /* UG,UG,U,A,U */+   280   280   280   280    /* UG,UG,U,C,A */+   280   280   280   280    /* UG,UG,U,C,C */+   280   280   280   280    /* UG,UG,U,C,G */+   280   280   280   280    /* UG,UG,U,C,U */+   310   370   310   310    /* UG,UG,U,G,A */+   280   280   280   280    /* UG,UG,U,G,C */+   150   150   150   280    /* UG,UG,U,G,G */+   280   280   280   280    /* UG,UG,U,G,U */+   280   280   280   280    /* UG,UG,U,U,A */+   280   280   280   280    /* UG,UG,U,U,C */+   280   280   280   280    /* UG,UG,U,U,G */+   280   280   280   280    /* UG,UG,U,U,U */+   240   280   310   280    /* UG,AU,A,A,A */+   220   250   280   250    /* UG,AU,A,A,C */+   120   150   180   150    /* UG,AU,A,A,G */+   220   250   280   250    /* UG,AU,A,A,U */+   230   260   290   260    /* UG,AU,A,C,A */+   220   260   350   260    /* UG,AU,A,C,C */+   230   260   290   260    /* UG,AU,A,C,G */+   220   260   350   260    /* UG,AU,A,C,U */+   190   220   250   220    /* UG,AU,A,G,A */+   220   250   280   250    /* UG,AU,A,G,C */+    70   100   260   100    /* UG,AU,A,G,G */+   220   250   280   250    /* UG,AU,A,G,U */+   230   260   290   260    /* UG,AU,A,U,A */+   220   260   350   260    /* UG,AU,A,U,C */+   230   260   290   260    /* UG,AU,A,U,G */+   190   170   200   170    /* UG,AU,A,U,U */+   280   280   280   280    /* UG,AU,C,A,A */+   250   250   250   250    /* UG,AU,C,A,C */+   150   210   150   210    /* UG,AU,C,A,G */+   250   250   250   250    /* UG,AU,C,A,U */+   260   260   260   260    /* UG,AU,C,C,A */+   260   260   260   260    /* UG,AU,C,C,C */+   260   260   260   260    /* UG,AU,C,C,G */+   260   260   260   260    /* UG,AU,C,C,U */+   220   280   220   280    /* UG,AU,C,G,A */+   250   250   250   250    /* UG,AU,C,G,C */+   100   100   100   100    /* UG,AU,C,G,G */+   250   250   250   250    /* UG,AU,C,G,U */+   260   260   260   260    /* UG,AU,C,U,A */+   260   260   260   260    /* UG,AU,C,U,C */+   260   260   260   260    /* UG,AU,C,U,G */+   170   170   170   170    /* UG,AU,C,U,U */+   140   280   150   280    /* UG,AU,G,A,A */+   120   250   120   250    /* UG,AU,G,A,C */+    20   150   150   150    /* UG,AU,G,A,G */+   120   250   120   250    /* UG,AU,G,A,U */+   130   260   130   260    /* UG,AU,G,C,A */+   180   260   130   260    /* UG,AU,G,C,C */+   130   260   130   260    /* UG,AU,G,C,G */+   180   260   130   260    /* UG,AU,G,C,U */+    90   220   220   220    /* UG,AU,G,G,A */+   120   250   120   250    /* UG,AU,G,G,C */+   100   100   230   100    /* UG,AU,G,G,G */+   120   250   120   250    /* UG,AU,G,G,U */+   130   260   130   260    /* UG,AU,G,U,A */+   180   260   130   260    /* UG,AU,G,U,C */+   130   260   130   260    /* UG,AU,G,U,G */+    30   170   170   170    /* UG,AU,G,U,U */+   280   280   280   340    /* UG,AU,U,A,A */+   250   250   250   250    /* UG,AU,U,A,C */+   150   210   150   150    /* UG,AU,U,A,G */+   250   250   250   250    /* UG,AU,U,A,U */+   260   260   260   260    /* UG,AU,U,C,A */+   260   260   260   260    /* UG,AU,U,C,C */+   260   260   260   260    /* UG,AU,U,C,G */+   260   260   260   260    /* UG,AU,U,C,U */+   220   280   220   220    /* UG,AU,U,G,A */+   250   250   250   250    /* UG,AU,U,G,C */+   100   100   100   230    /* UG,AU,U,G,G */+   250   250   250   250    /* UG,AU,U,G,U */+   260   260   260   260    /* UG,AU,U,U,A */+   260   260   260   260    /* UG,AU,U,U,C */+   260   260   260   260    /* UG,AU,U,U,G */+   170   170   170   170    /* UG,AU,U,U,U */+   240   280   310   280    /* UG,UA,A,A,A */+   200   230   260   230    /* UG,UA,A,A,C */+   140   170   200   170    /* UG,UA,A,A,G */+   200   230   260   230    /* UG,UA,A,A,U */+   240   280   310   280    /* UG,UA,A,C,A */+   240   280   370   280    /* UG,UA,A,C,C */+   240   280   310   280    /* UG,UA,A,C,G */+   240   280   370   280    /* UG,UA,A,C,U */+   150   180   210   180    /* UG,UA,A,G,A */+   200   230   260   230    /* UG,UA,A,G,C */+    90   120   280   120    /* UG,UA,A,G,G */+   200   230   260   230    /* UG,UA,A,G,U */+   240   280   310   280    /* UG,UA,A,U,A */+   210   250   340   250    /* UG,UA,A,U,C */+   240   280   310   280    /* UG,UA,A,U,G */+   220   190   220   190    /* UG,UA,A,U,U */+   280   280   280   280    /* UG,UA,C,A,A */+   230   230   230   230    /* UG,UA,C,A,C */+   170   230   170   230    /* UG,UA,C,A,G */+   230   230   230   230    /* UG,UA,C,A,U */+   280   280   280   280    /* UG,UA,C,C,A */+   280   280   280   280    /* UG,UA,C,C,C */+   280   280   280   280    /* UG,UA,C,C,G */+   280   280   280   280    /* UG,UA,C,C,U */+   180   240   180   240    /* UG,UA,C,G,A */+   230   230   230   230    /* UG,UA,C,G,C */+   120   120   120   120    /* UG,UA,C,G,G */+   230   230   230   230    /* UG,UA,C,G,U */+   280   280   280   280    /* UG,UA,C,U,A */+   250   250   250   250    /* UG,UA,C,U,C */+   280   280   280   280    /* UG,UA,C,U,G */+   190   190   190   190    /* UG,UA,C,U,U */+   140   280   150   280    /* UG,UA,G,A,A */+   100   230   100   230    /* UG,UA,G,A,C */+    40   170   170   170    /* UG,UA,G,A,G */+   100   230   100   230    /* UG,UA,G,A,U */+   140   280   150   280    /* UG,UA,G,C,A */+   200   280   150   280    /* UG,UA,G,C,C */+   140   280   150   280    /* UG,UA,G,C,G */+   200   280   150   280    /* UG,UA,G,C,U */+    50   180   180   180    /* UG,UA,G,G,A */+   100   230   100   230    /* UG,UA,G,G,C */+   120   120   250   120    /* UG,UA,G,G,G */+   100   230   100   230    /* UG,UA,G,G,U */+   140   280   150   280    /* UG,UA,G,U,A */+   170   250   120   250    /* UG,UA,G,U,C */+   140   280   150   280    /* UG,UA,G,U,G */+    60   190   190   190    /* UG,UA,G,U,U */+   280   280   280   340    /* UG,UA,U,A,A */+   230   230   230   230    /* UG,UA,U,A,C */+   170   230   170   170    /* UG,UA,U,A,G */+   230   230   230   230    /* UG,UA,U,A,U */+   280   280   280   280    /* UG,UA,U,C,A */+   280   280   280   280    /* UG,UA,U,C,C */+   280   280   280   280    /* UG,UA,U,C,G */+   280   280   280   280    /* UG,UA,U,C,U */+   180   240   180   180    /* UG,UA,U,G,A */+   230   230   230   230    /* UG,UA,U,G,C */+   120   120   120   250    /* UG,UA,U,G,G */+   230   230   230   230    /* UG,UA,U,G,U */+   280   280   280   280    /* UG,UA,U,U,A */+   250   250   250   250    /* UG,UA,U,U,C */+   280   280   280   280    /* UG,UA,U,U,G */+   190   190   190   190    /* UG,UA,U,U,U */+   200   180   140   180    /* AU,CG,A,A,A */+   190   180   140   180    /* AU,CG,A,A,C */+   100    90    50    90    /* AU,CG,A,A,G */+   190   180   140   180    /* AU,CG,A,A,U */+   240   220   180   220    /* AU,CG,A,C,A */+   220   210   230   210    /* AU,CG,A,C,C */+   240   220   180   220    /* AU,CG,A,C,G */+   210   190   210   190    /* AU,CG,A,C,U */+   100    90    50    90    /* AU,CG,A,G,A */+   190   180   140   180    /* AU,CG,A,G,C */+    50    30   120    30    /* AU,CG,A,G,G */+   190   180   140   180    /* AU,CG,A,G,U */+   240   220   180   220    /* AU,CG,A,U,A */+   210   190   210   190    /* AU,CG,A,U,C */+   240   220   180   220    /* AU,CG,A,U,G */+   180   100    60   100    /* AU,CG,A,U,U */+   170   180   170   180    /* AU,CG,C,A,A */+   170   170   170   170    /* AU,CG,C,A,C */+    80   140    80   140    /* AU,CG,C,A,G */+   170   170   170   170    /* AU,CG,C,A,U */+   210   220   210   220    /* AU,CG,C,C,A */+   200   200   200   200    /* AU,CG,C,C,C */+   210   220   210   220    /* AU,CG,C,C,G */+   180   190   180   190    /* AU,CG,C,C,U */+    80   140    80   140    /* AU,CG,C,G,A */+   170   170   170   170    /* AU,CG,C,G,C */+    20    30    20    30    /* AU,CG,C,G,G */+   170   170   170   170    /* AU,CG,C,G,U */+   210   220   210   220    /* AU,CG,C,U,A */+   180   190   180   190    /* AU,CG,C,U,C */+   210   220   210   220    /* AU,CG,C,U,G */+    90   100    90   100    /* AU,CG,C,U,U */+    70   180    20   180    /* AU,CG,G,A,A */+    70   180    20   180    /* AU,CG,G,A,C */+   -20    90    60    90    /* AU,CG,G,A,G */+    70   180    20   180    /* AU,CG,G,A,U */+   110   220    60   220    /* AU,CG,G,C,A */+   160   210    50   210    /* AU,CG,G,C,C */+   110   220    60   220    /* AU,CG,G,C,G */+   140   190    30   190    /* AU,CG,G,C,U */+   -20    90    60    90    /* AU,CG,G,G,A */+    70   180    20   180    /* AU,CG,G,G,C */+    50    30   130    30    /* AU,CG,G,G,G */+    70   180    20   180    /* AU,CG,G,G,U */+   110   220    60   220    /* AU,CG,G,U,A */+   140   190    30   190    /* AU,CG,G,U,C */+   110   220    60   220    /* AU,CG,G,U,G */+     0   100    70   100    /* AU,CG,G,U,U */+   170   180   170   150    /* AU,CG,U,A,A */+   170   170   170    80    /* AU,CG,U,A,C */+    80   140    80     0    /* AU,CG,U,A,G */+   170   170   170    80    /* AU,CG,U,A,U */+   210   220   210   130    /* AU,CG,U,C,A */+   200   200   200   110    /* AU,CG,U,C,C */+   210   220   210   130    /* AU,CG,U,C,G */+   180   190   180   100    /* AU,CG,U,C,U */+    80   140    80     0    /* AU,CG,U,G,A */+   170   170   170    80    /* AU,CG,U,G,C */+    20    30    20    70    /* AU,CG,U,G,G */+   170   170   170    80    /* AU,CG,U,G,U */+   210   220   210   130    /* AU,CG,U,U,A */+   180   190   180   100    /* AU,CG,U,U,C */+   210   220   210   130    /* AU,CG,U,U,G */+    90   100    90    10    /* AU,CG,U,U,U */+   210   200   160   200    /* AU,GC,A,A,A */+   190   170   130   170    /* AU,GC,A,A,C */+    10     0   -40     0    /* AU,GC,A,A,G */+   190   170   130   170    /* AU,GC,A,A,U */+   180   170   130   170    /* AU,GC,A,C,A */+   190   170   190   170    /* AU,GC,A,C,C */+   180   170   130   170    /* AU,GC,A,C,G */+   190   170   190   170    /* AU,GC,A,C,U */+    70    60    20    60    /* AU,GC,A,G,A */+   190   170   130   170    /* AU,GC,A,G,C */+    50    30   120    30    /* AU,GC,A,G,G */+   190   170   130   170    /* AU,GC,A,G,U */+   180   170   130   170    /* AU,GC,A,U,A */+   190   180   200   180    /* AU,GC,A,U,C */+   180   170   130   170    /* AU,GC,A,U,G */+   170   100    60   100    /* AU,GC,A,U,U */+   190   190   190   190    /* AU,GC,C,A,A */+   160   170   160   170    /* AU,GC,C,A,C */+   -10    50   -10    50    /* AU,GC,C,A,G */+   160   170   160   170    /* AU,GC,C,A,U */+   160   160   160   160    /* AU,GC,C,C,A */+   160   170   160   170    /* AU,GC,C,C,C */+   160   160   160   160    /* AU,GC,C,C,G */+   160   170   160   170    /* AU,GC,C,C,U */+    50   110    50   110    /* AU,GC,C,G,A */+   160   170   160   170    /* AU,GC,C,G,C */+    20    30    20    30    /* AU,GC,C,G,G */+   160   170   160   170    /* AU,GC,C,G,U */+   160   160   160   160    /* AU,GC,C,U,A */+   170   170   170   170    /* AU,GC,C,U,C */+   160   160   160   160    /* AU,GC,C,U,G */+    90    90    90    90    /* AU,GC,C,U,U */+    90   200    40   200    /* AU,GC,G,A,A */+    60   170    10   170    /* AU,GC,G,A,C */+  -110     0   -30     0    /* AU,GC,G,A,G */+    60   170    10   170    /* AU,GC,G,A,U */+    60   170    10   170    /* AU,GC,G,C,A */+   120   170    10   170    /* AU,GC,G,C,C */+    60   170    10   170    /* AU,GC,G,C,G */+   120   170    10   170    /* AU,GC,G,C,U */+   -50    60    30    60    /* AU,GC,G,G,A */+    60   170    10   170    /* AU,GC,G,G,C */+    50    30   130    30    /* AU,GC,G,G,G */+    60   170    10   170    /* AU,GC,G,G,U */+    60   170    10   170    /* AU,GC,G,U,A */+   130   180    20   180    /* AU,GC,G,U,C */+    60   170    10   170    /* AU,GC,G,U,G */+   -10   100    70   100    /* AU,GC,G,U,U */+   190   190   190   160    /* AU,GC,U,A,A */+   160   170   160    80    /* AU,GC,U,A,C */+   -10    50   -10  -100    /* AU,GC,U,A,G */+   160   170   160    80    /* AU,GC,U,A,U */+   160   160   160    70    /* AU,GC,U,C,A */+   160   170   160    80    /* AU,GC,U,C,C */+   160   160   160    70    /* AU,GC,U,C,G */+   160   170   160    80    /* AU,GC,U,C,U */+    50   110    50   -30    /* AU,GC,U,G,A */+   160   170   160    80    /* AU,GC,U,G,C */+    20    30    20    70    /* AU,GC,U,G,G */+   160   170   160    80    /* AU,GC,U,G,U */+   160   160   160    70    /* AU,GC,U,U,A */+   170   170   170    80    /* AU,GC,U,U,C */+   160   160   160    70    /* AU,GC,U,U,G */+    90    90    90     0    /* AU,GC,U,U,U */+   340   330   290   330    /* AU,GU,A,A,A */+   310   290   250   290    /* AU,GU,A,A,C */+   230   210   170   210    /* AU,GU,A,A,G */+   310   290   250   290    /* AU,GU,A,A,U */+   310   290   250   290    /* AU,GU,A,C,A */+   310   290   310   290    /* AU,GU,A,C,C */+   310   290   250   290    /* AU,GU,A,C,G */+   310   290   310   290    /* AU,GU,A,C,U */+   270   250   210   250    /* AU,GU,A,G,A */+   310   290   250   290    /* AU,GU,A,G,C */+   180   160   250   160    /* AU,GU,A,G,G */+   310   290   250   290    /* AU,GU,A,G,U */+   310   290   250   290    /* AU,GU,A,U,A */+   310   290   310   290    /* AU,GU,A,U,C */+   310   290   250   290    /* AU,GU,A,U,G */+   370   290   250   290    /* AU,GU,A,U,U */+   320   320   320   320    /* AU,GU,C,A,A */+   280   290   280   290    /* AU,GU,C,A,C */+   200   270   200   270    /* AU,GU,C,A,G */+   280   290   280   290    /* AU,GU,C,A,U */+   280   290   280   290    /* AU,GU,C,C,A */+   280   290   280   290    /* AU,GU,C,C,C */+   280   290   280   290    /* AU,GU,C,C,G */+   280   290   280   290    /* AU,GU,C,C,U */+   240   310   240   310    /* AU,GU,C,G,A */+   280   290   280   290    /* AU,GU,C,G,C */+   150   160   150   160    /* AU,GU,C,G,G */+   280   290   280   290    /* AU,GU,C,G,U */+   280   290   280   290    /* AU,GU,C,U,A */+   280   290   280   290    /* AU,GU,C,U,C */+   280   290   280   290    /* AU,GU,C,U,G */+   280   290   280   290    /* AU,GU,C,U,U */+   220   330   170   330    /* AU,GU,G,A,A */+   180   290   130   290    /* AU,GU,G,A,C */+   100   210   180   210    /* AU,GU,G,A,G */+   180   290   130   290    /* AU,GU,G,A,U */+   180   290   130   290    /* AU,GU,G,C,A */+   240   290   130   290    /* AU,GU,G,C,C */+   180   290   130   290    /* AU,GU,G,C,G */+   240   290   130   290    /* AU,GU,G,C,U */+   140   250   220   250    /* AU,GU,G,G,A */+   180   290   130   290    /* AU,GU,G,G,C */+   180   160   260   160    /* AU,GU,G,G,G */+   180   290   130   290    /* AU,GU,G,G,U */+   180   290   130   290    /* AU,GU,G,U,A */+   240   290   130   290    /* AU,GU,G,U,C */+   180   290   130   290    /* AU,GU,G,U,G */+   180   290   260   290    /* AU,GU,G,U,U */+   320   320   320   290    /* AU,GU,U,A,A */+   280   290   280   200    /* AU,GU,U,A,C */+   200   270   200   120    /* AU,GU,U,A,G */+   280   290   280   200    /* AU,GU,U,A,U */+   280   290   280   200    /* AU,GU,U,C,A */+   280   290   280   200    /* AU,GU,U,C,C */+   280   290   280   200    /* AU,GU,U,C,G */+   280   290   280   200    /* AU,GU,U,C,U */+   240   310   240   160    /* AU,GU,U,G,A */+   280   290   280   200    /* AU,GU,U,G,C */+   150   160   150   200    /* AU,GU,U,G,G */+   280   290   280   200    /* AU,GU,U,G,U */+   280   290   280   200    /* AU,GU,U,U,A */+   280   290   280   200    /* AU,GU,U,U,C */+   280   290   280   200    /* AU,GU,U,U,G */+   280   290   280   200    /* AU,GU,U,U,U */+   240   230   190   230    /* AU,UG,A,A,A */+   280   260   220   260    /* AU,UG,A,A,C */+   140   130    90   130    /* AU,UG,A,A,G */+   280   260   220   260    /* AU,UG,A,A,U */+   280   260   220   260    /* AU,UG,A,C,A */+   280   260   280   260    /* AU,UG,A,C,C */+   280   260   220   260    /* AU,UG,A,C,G */+   280   260   280   260    /* AU,UG,A,C,U */+   310   290   250   290    /* AU,UG,A,G,A */+   280   260   220   260    /* AU,UG,A,G,C */+   150   130   220   130    /* AU,UG,A,G,G */+   280   260   220   260    /* AU,UG,A,G,U */+   280   260   220   260    /* AU,UG,A,U,A */+   280   260   280   260    /* AU,UG,A,U,C */+   280   260   220   260    /* AU,UG,A,U,G */+   340   260   220   260    /* AU,UG,A,U,U */+   220   220   220   220    /* AU,UG,C,A,A */+   250   260   250   260    /* AU,UG,C,A,C */+   120   180   120   180    /* AU,UG,C,A,G */+   250   260   250   260    /* AU,UG,C,A,U */+   250   260   250   260    /* AU,UG,C,C,A */+   250   260   250   260    /* AU,UG,C,C,C */+   250   260   250   260    /* AU,UG,C,C,G */+   250   260   250   260    /* AU,UG,C,C,U */+   280   350   280   350    /* AU,UG,C,G,A */+   250   260   250   260    /* AU,UG,C,G,C */+   120   130   120   130    /* AU,UG,C,G,G */+   250   260   250   260    /* AU,UG,C,G,U */+   250   260   250   260    /* AU,UG,C,U,A */+   250   260   250   260    /* AU,UG,C,U,C */+   250   260   250   260    /* AU,UG,C,U,G */+   250   260   250   260    /* AU,UG,C,U,U */+   120   230    70   230    /* AU,UG,G,A,A */+   150   260   100   260    /* AU,UG,G,A,C */+    20   130   100   130    /* AU,UG,G,A,G */+   150   260   100   260    /* AU,UG,G,A,U */+   150   260   100   260    /* AU,UG,G,C,A */+   210   260   100   260    /* AU,UG,G,C,C */+   150   260   100   260    /* AU,UG,G,C,G */+   210   260   100   260    /* AU,UG,G,C,U */+   180   290   260   290    /* AU,UG,G,G,A */+   150   260   100   260    /* AU,UG,G,G,C */+   150   130   230   130    /* AU,UG,G,G,G */+   150   260   100   260    /* AU,UG,G,G,U */+   150   260   100   260    /* AU,UG,G,U,A */+   210   260   100   260    /* AU,UG,G,U,C */+   150   260   100   260    /* AU,UG,G,U,G */+   150   260   230   260    /* AU,UG,G,U,U */+   220   220   220   190    /* AU,UG,U,A,A */+   250   260   250   170    /* AU,UG,U,A,C */+   120   180   120    30    /* AU,UG,U,A,G */+   250   260   250   170    /* AU,UG,U,A,U */+   250   260   250   170    /* AU,UG,U,C,A */+   250   260   250   170    /* AU,UG,U,C,C */+   250   260   250   170    /* AU,UG,U,C,G */+   250   260   250   170    /* AU,UG,U,C,U */+   280   350   280   200    /* AU,UG,U,G,A */+   250   260   250   170    /* AU,UG,U,G,C */+   120   130   120   170    /* AU,UG,U,G,G */+   250   260   250   170    /* AU,UG,U,G,U */+   250   260   250   170    /* AU,UG,U,U,A */+   250   260   250   170    /* AU,UG,U,U,C */+   250   260   250   170    /* AU,UG,U,U,G */+   250   260   250   170    /* AU,UG,U,U,U */+   280   260   220   260    /* AU,AU,A,A,A */+   250   240   200   240    /* AU,AU,A,A,C */+   150   140   100   140    /* AU,AU,A,A,G */+   250   240   200   240    /* AU,AU,A,A,U */+   260   250   210   250    /* AU,AU,A,C,A */+   260   240   260   240    /* AU,AU,A,C,C */+   260   250   210   250    /* AU,AU,A,C,G */+   260   240   260   240    /* AU,AU,A,C,U */+   220   210   170   210    /* AU,AU,A,G,A */+   250   240   200   240    /* AU,AU,A,G,C */+   100    90   180    90    /* AU,AU,A,G,G */+   250   240   200   240    /* AU,AU,A,G,U */+   260   250   210   250    /* AU,AU,A,U,A */+   260   240   260   240    /* AU,AU,A,U,C */+   260   250   210   250    /* AU,AU,A,U,G */+   230   150   110   150    /* AU,AU,A,U,U */+   250   260   250   260    /* AU,AU,C,A,A */+   230   230   230   230    /* AU,AU,C,A,C */+   130   190   130   190    /* AU,AU,C,A,G */+   230   230   230   230    /* AU,AU,C,A,U */+   240   240   240   240    /* AU,AU,C,C,A */+   230   240   230   240    /* AU,AU,C,C,C */+   240   240   240   240    /* AU,AU,C,C,G */+   230   240   230   240    /* AU,AU,C,C,U */+   200   260   200   260    /* AU,AU,C,G,A */+   230   230   230   230    /* AU,AU,C,G,C */+    80    80    80    80    /* AU,AU,C,G,G */+   230   230   230   230    /* AU,AU,C,G,U */+   240   240   240   240    /* AU,AU,C,U,A */+   230   240   230   240    /* AU,AU,C,U,C */+   240   240   240   240    /* AU,AU,C,U,G */+   140   150   140   150    /* AU,AU,C,U,U */+   150   260   100   260    /* AU,AU,G,A,A */+   130   240    80   240    /* AU,AU,G,A,C */+    30   140   110   140    /* AU,AU,G,A,G */+   130   240    80   240    /* AU,AU,G,A,U */+   140   250    90   250    /* AU,AU,G,C,A */+   190   240    80   240    /* AU,AU,G,C,C */+   140   250    90   250    /* AU,AU,G,C,G */+   190   240    80   240    /* AU,AU,G,C,U */+   100   210   180   210    /* AU,AU,G,G,A */+   130   240    80   240    /* AU,AU,G,G,C */+   110    90   190    90    /* AU,AU,G,G,G */+   130   240    80   240    /* AU,AU,G,G,U */+   140   250    90   250    /* AU,AU,G,U,A */+   190   240    80   240    /* AU,AU,G,U,C */+   140   250    90   250    /* AU,AU,G,U,G */+    40   150   120   150    /* AU,AU,G,U,U */+   250   260   250   230    /* AU,AU,U,A,A */+   230   230   230   140    /* AU,AU,U,A,C */+   130   190   130    40    /* AU,AU,U,A,G */+   230   230   230   140    /* AU,AU,U,A,U */+   240   240   240   150    /* AU,AU,U,C,A */+   230   240   230   150    /* AU,AU,U,C,C */+   240   240   240   150    /* AU,AU,U,C,G */+   230   240   230   150    /* AU,AU,U,C,U */+   200   260   200   110    /* AU,AU,U,G,A */+   230   230   230   140    /* AU,AU,U,G,C */+    80    80    80   120    /* AU,AU,U,G,G */+   230   230   230   140    /* AU,AU,U,G,U */+   240   240   240   150    /* AU,AU,U,U,A */+   230   240   230   150    /* AU,AU,U,U,C */+   240   240   240   150    /* AU,AU,U,U,G */+   140   150   140    60    /* AU,AU,U,U,U */+   280   260   220   260    /* AU,UA,A,A,A */+   230   220   180   220    /* AU,UA,A,A,C */+   170   160   120   160    /* AU,UA,A,A,G */+   230   220   180   220    /* AU,UA,A,A,U */+   280   260   220   260    /* AU,UA,A,C,A */+   280   260   280   260    /* AU,UA,A,C,C */+   280   260   220   260    /* AU,UA,A,C,G */+   280   260   280   260    /* AU,UA,A,C,U */+   180   170   130   170    /* AU,UA,A,G,A */+   230   220   180   220    /* AU,UA,A,G,C */+   120   110   200   110    /* AU,UA,A,G,G */+   230   220   180   220    /* AU,UA,A,G,U */+   280   260   220   260    /* AU,UA,A,U,A */+   250   230   250   230    /* AU,UA,A,U,C */+   280   260   220   260    /* AU,UA,A,U,G */+   250   180   140   180    /* AU,UA,A,U,U */+   250   260   250   260    /* AU,UA,C,A,A */+   210   210   210   210    /* AU,UA,C,A,C */+   150   210   150   210    /* AU,UA,C,A,G */+   210   210   210   210    /* AU,UA,C,A,U */+   250   260   250   260    /* AU,UA,C,C,A */+   250   260   250   260    /* AU,UA,C,C,C */+   250   260   250   260    /* AU,UA,C,C,G */+   250   260   250   260    /* AU,UA,C,C,U */+   160   220   160   220    /* AU,UA,C,G,A */+   210   210   210   210    /* AU,UA,C,G,C */+   100   100   100   100    /* AU,UA,C,G,G */+   210   210   210   210    /* AU,UA,C,G,U */+   250   260   250   260    /* AU,UA,C,U,A */+   220   230   220   230    /* AU,UA,C,U,C */+   250   260   250   260    /* AU,UA,C,U,G */+   170   170   170   170    /* AU,UA,C,U,U */+   150   260   100   260    /* AU,UA,G,A,A */+   110   220    60   220    /* AU,UA,G,A,C */+    50   160   130   160    /* AU,UA,G,A,G */+   110   220    60   220    /* AU,UA,G,A,U */+   150   260   100   260    /* AU,UA,G,C,A */+   210   260   100   260    /* AU,UA,G,C,C */+   150   260   100   260    /* AU,UA,G,C,G */+   210   260   100   260    /* AU,UA,G,C,U */+    60   170   140   170    /* AU,UA,G,G,A */+   110   220    60   220    /* AU,UA,G,G,C */+   130   110   210   110    /* AU,UA,G,G,G */+   110   220    60   220    /* AU,UA,G,G,U */+   150   260   100   260    /* AU,UA,G,U,A */+   180   230    70   230    /* AU,UA,G,U,C */+   150   260   100   260    /* AU,UA,G,U,G */+    70   180   150   180    /* AU,UA,G,U,U */+   250   260   250   230    /* AU,UA,U,A,A */+   210   210   210   120    /* AU,UA,U,A,C */+   150   210   150    60    /* AU,UA,U,A,G */+   210   210   210   120    /* AU,UA,U,A,U */+   250   260   250   170    /* AU,UA,U,C,A */+   250   260   250   170    /* AU,UA,U,C,C */+   250   260   250   170    /* AU,UA,U,C,G */+   250   260   250   170    /* AU,UA,U,C,U */+   160   220   160    70    /* AU,UA,U,G,A */+   210   210   210   120    /* AU,UA,U,G,C */+   100   100   100   140    /* AU,UA,U,G,G */+   210   210   210   120    /* AU,UA,U,G,U */+   250   260   250   170    /* AU,UA,U,U,A */+   220   230   220   140    /* AU,UA,U,U,C */+   250   260   250   170    /* AU,UA,U,U,G */+   170   170   170    80    /* AU,UA,U,U,U */+   200   200   100   200    /* UA,CG,A,A,A */+   190   190   100   190    /* UA,CG,A,A,C */+   100   100    10   100    /* UA,CG,A,A,G */+   190   190   100   190    /* UA,CG,A,A,U */+   240   240   140   240    /* UA,CG,A,C,A */+   220   220   190   220    /* UA,CG,A,C,C */+   240   240   140   240    /* UA,CG,A,C,G */+   210   210   170   210    /* UA,CG,A,C,U */+   100   100    10   100    /* UA,CG,A,G,A */+   190   190   100   190    /* UA,CG,A,G,C */+    50    50    80    50    /* UA,CG,A,G,G */+   190   190   100   190    /* UA,CG,A,G,U */+   240   240   140   240    /* UA,CG,A,U,A */+   210   210   170   210    /* UA,CG,A,U,C */+   240   240   140   240    /* UA,CG,A,U,G */+   180   120    20   120    /* UA,CG,A,U,U */+   150   200   150   170    /* UA,CG,C,A,A */+   150   190   150   160    /* UA,CG,C,A,C */+    60   160    60   130    /* UA,CG,C,A,G */+   150   190   150   160    /* UA,CG,C,A,U */+   190   240   190   210    /* UA,CG,C,C,A */+   180   220   180   190    /* UA,CG,C,C,C */+   190   240   190   210    /* UA,CG,C,C,G */+   160   210   160   180    /* UA,CG,C,C,U */+    60   160    60   130    /* UA,CG,C,G,A */+   150   190   150   160    /* UA,CG,C,G,C */+     0    50     0    20    /* UA,CG,C,G,G */+   150   190   150   160    /* UA,CG,C,G,U */+   190   240   190   210    /* UA,CG,C,U,A */+   160   210   160   180    /* UA,CG,C,U,C */+   190   240   190   210    /* UA,CG,C,U,G */+    70   120    70    90    /* UA,CG,C,U,U */+    90   200    40   200    /* UA,CG,G,A,A */+    90   190    40   190    /* UA,CG,G,A,C */+     0   100    80   100    /* UA,CG,G,A,G */+    90   190    40   190    /* UA,CG,G,A,U */+   130   240    80   240    /* UA,CG,G,C,A */+   180   220    70   220    /* UA,CG,G,C,C */+   130   240    80   240    /* UA,CG,G,C,G */+   160   210    50   210    /* UA,CG,G,C,U */+     0   100    80   100    /* UA,CG,G,G,A */+    90   190    40   190    /* UA,CG,G,G,C */+    70    50   150    50    /* UA,CG,G,G,G */+    90   190    40   190    /* UA,CG,G,G,U */+   130   240    80   240    /* UA,CG,G,U,A */+   160   210    50   210    /* UA,CG,G,U,C */+   130   240    80   240    /* UA,CG,G,U,G */+    10   120    90   120    /* UA,CG,G,U,U */+   150   200   150   170    /* UA,CG,U,A,A */+   150   190   150   110    /* UA,CG,U,A,C */+    60   160    60    20    /* UA,CG,U,A,G */+   150   190   150   110    /* UA,CG,U,A,U */+   190   240   190   150    /* UA,CG,U,C,A */+   180   220   180   140    /* UA,CG,U,C,C */+   190   240   190   150    /* UA,CG,U,C,G */+   160   210   160   120    /* UA,CG,U,C,U */+    60   160    60    20    /* UA,CG,U,G,A */+   150   190   150   110    /* UA,CG,U,G,C */+     0    50     0    90    /* UA,CG,U,G,G */+   150   190   150   110    /* UA,CG,U,G,U */+   190   240   190   150    /* UA,CG,U,U,A */+   160   210   160   120    /* UA,CG,U,U,C */+   190   240   190   150    /* UA,CG,U,U,G */+    70   120    70    30    /* UA,CG,U,U,U */+   210   210   120   210    /* UA,GC,A,A,A */+   190   190    90   190    /* UA,GC,A,A,C */+    10    10   -80    10    /* UA,GC,A,A,G */+   190   190    90   190    /* UA,GC,A,A,U */+   180   180    90   180    /* UA,GC,A,C,A */+   190   190   150   190    /* UA,GC,A,C,C */+   180   180    90   180    /* UA,GC,A,C,G */+   190   190   150   190    /* UA,GC,A,C,U */+    70    70   -20    70    /* UA,GC,A,G,A */+   190   190    90   190    /* UA,GC,A,G,C */+    50    50    80    50    /* UA,GC,A,G,G */+   190   190    90   190    /* UA,GC,A,G,U */+   180   180    90   180    /* UA,GC,A,U,A */+   190   190   160   190    /* UA,GC,A,U,C */+   180   180    90   180    /* UA,GC,A,U,G */+   170   110    20   110    /* UA,GC,A,U,U */+   170   210   170   180    /* UA,GC,C,A,A */+   140   190   140   160    /* UA,GC,C,A,C */+   -30    70   -30    40    /* UA,GC,C,A,G */+   140   190   140   160    /* UA,GC,C,A,U */+   140   180   140   150    /* UA,GC,C,C,A */+   140   190   140   160    /* UA,GC,C,C,C */+   140   180   140   150    /* UA,GC,C,C,G */+   140   190   140   160    /* UA,GC,C,C,U */+    30   130    30   100    /* UA,GC,C,G,A */+   140   190   140   160    /* UA,GC,C,G,C */+     0    50     0    20    /* UA,GC,C,G,G */+   140   190   140   160    /* UA,GC,C,G,U */+   140   180   140   150    /* UA,GC,C,U,A */+   150   190   150   160    /* UA,GC,C,U,C */+   140   180   140   150    /* UA,GC,C,U,G */+    70   110    70    80    /* UA,GC,C,U,U */+   110   210    60   210    /* UA,GC,G,A,A */+    80   190    30   190    /* UA,GC,G,A,C */+   -90    10   -10    10    /* UA,GC,G,A,G */+    80   190    30   190    /* UA,GC,G,A,U */+    80   180    30   180    /* UA,GC,G,C,A */+   140   190    30   190    /* UA,GC,G,C,C */+    80   180    30   180    /* UA,GC,G,C,G */+   140   190    30   190    /* UA,GC,G,C,U */+   -30    70    50    70    /* UA,GC,G,G,A */+    80   190    30   190    /* UA,GC,G,G,C */+    70    50   150    50    /* UA,GC,G,G,G */+    80   190    30   190    /* UA,GC,G,G,U */+    80   180    30   180    /* UA,GC,G,U,A */+   150   190    40   190    /* UA,GC,G,U,C */+    80   180    30   180    /* UA,GC,G,U,G */+    10   110    90   110    /* UA,GC,G,U,U */+   170   210   170   190    /* UA,GC,U,A,A */+   140   190   140   100    /* UA,GC,U,A,C */+   -30    70   -30   -70    /* UA,GC,U,A,G */+   140   190   140   100    /* UA,GC,U,A,U */+   140   180   140   100    /* UA,GC,U,C,A */+   140   190   140   100    /* UA,GC,U,C,C */+   140   180   140   100    /* UA,GC,U,C,G */+   140   190   140   100    /* UA,GC,U,C,U */+    30   130    30   -10    /* UA,GC,U,G,A */+   140   190   140   100    /* UA,GC,U,G,C */+     0    50     0    90    /* UA,GC,U,G,G */+   140   190   140   100    /* UA,GC,U,G,U */+   140   180   140   100    /* UA,GC,U,U,A */+   150   190   150   110    /* UA,GC,U,U,C */+   140   180   140   100    /* UA,GC,U,U,G */+    70   110    70    30    /* UA,GC,U,U,U */+   340   340   250   340    /* UA,GU,A,A,A */+   310   310   210   310    /* UA,GU,A,A,C */+   230   230   130   230    /* UA,GU,A,A,G */+   310   310   210   310    /* UA,GU,A,A,U */+   310   310   210   310    /* UA,GU,A,C,A */+   310   310   270   310    /* UA,GU,A,C,C */+   310   310   210   310    /* UA,GU,A,C,G */+   310   310   270   310    /* UA,GU,A,C,U */+   270   270   170   270    /* UA,GU,A,G,A */+   310   310   210   310    /* UA,GU,A,G,C */+   180   180   210   180    /* UA,GU,A,G,G */+   310   310   210   310    /* UA,GU,A,G,U */+   310   310   210   310    /* UA,GU,A,U,A */+   310   310   270   310    /* UA,GU,A,U,C */+   310   310   210   310    /* UA,GU,A,U,G */+   370   310   210   310    /* UA,GU,A,U,U */+   300   340   300   310    /* UA,GU,C,A,A */+   260   310   260   280    /* UA,GU,C,A,C */+   180   290   180   260    /* UA,GU,C,A,G */+   260   310   260   280    /* UA,GU,C,A,U */+   260   310   260   280    /* UA,GU,C,C,A */+   260   310   260   280    /* UA,GU,C,C,C */+   260   310   260   280    /* UA,GU,C,C,G */+   260   310   260   280    /* UA,GU,C,C,U */+   220   330   220   300    /* UA,GU,C,G,A */+   260   310   260   280    /* UA,GU,C,G,C */+   130   180   130   150    /* UA,GU,C,G,G */+   260   310   260   280    /* UA,GU,C,G,U */+   260   310   260   280    /* UA,GU,C,U,A */+   260   310   260   280    /* UA,GU,C,U,C */+   260   310   260   280    /* UA,GU,C,U,G */+   260   310   260   280    /* UA,GU,C,U,U */+   240   340   190   340    /* UA,GU,G,A,A */+   200   310   150   310    /* UA,GU,G,A,C */+   120   230   200   230    /* UA,GU,G,A,G */+   200   310   150   310    /* UA,GU,G,A,U */+   200   310   150   310    /* UA,GU,G,C,A */+   260   310   150   310    /* UA,GU,G,C,C */+   200   310   150   310    /* UA,GU,G,C,G */+   260   310   150   310    /* UA,GU,G,C,U */+   160   270   240   270    /* UA,GU,G,G,A */+   200   310   150   310    /* UA,GU,G,G,C */+   200   180   280   180    /* UA,GU,G,G,G */+   200   310   150   310    /* UA,GU,G,G,U */+   200   310   150   310    /* UA,GU,G,U,A */+   260   310   150   310    /* UA,GU,G,U,C */+   200   310   150   310    /* UA,GU,G,U,G */+   200   310   280   310    /* UA,GU,G,U,U */+   300   340   300   320    /* UA,GU,U,A,A */+   260   310   260   220    /* UA,GU,U,A,C */+   180   290   180   140    /* UA,GU,U,A,G */+   260   310   260   220    /* UA,GU,U,A,U */+   260   310   260   220    /* UA,GU,U,C,A */+   260   310   260   220    /* UA,GU,U,C,C */+   260   310   260   220    /* UA,GU,U,C,G */+   260   310   260   220    /* UA,GU,U,C,U */+   220   330   220   180    /* UA,GU,U,G,A */+   260   310   260   220    /* UA,GU,U,G,C */+   130   180   130   220    /* UA,GU,U,G,G */+   260   310   260   220    /* UA,GU,U,G,U */+   260   310   260   220    /* UA,GU,U,U,A */+   260   310   260   220    /* UA,GU,U,U,C */+   260   310   260   220    /* UA,GU,U,U,G */+   260   310   260   220    /* UA,GU,U,U,U */+   240   240   150   240    /* UA,UG,A,A,A */+   280   280   180   280    /* UA,UG,A,A,C */+   140   140    50   140    /* UA,UG,A,A,G */+   280   280   180   280    /* UA,UG,A,A,U */+   280   280   180   280    /* UA,UG,A,C,A */+   280   280   240   280    /* UA,UG,A,C,C */+   280   280   180   280    /* UA,UG,A,C,G */+   280   280   240   280    /* UA,UG,A,C,U */+   310   310   210   310    /* UA,UG,A,G,A */+   280   280   180   280    /* UA,UG,A,G,C */+   150   150   180   150    /* UA,UG,A,G,G */+   280   280   180   280    /* UA,UG,A,G,U */+   280   280   180   280    /* UA,UG,A,U,A */+   280   280   240   280    /* UA,UG,A,U,C */+   280   280   180   280    /* UA,UG,A,U,G */+   340   280   180   280    /* UA,UG,A,U,U */+   200   240   200   210    /* UA,UG,C,A,A */+   230   280   230   250    /* UA,UG,C,A,C */+   100   200   100   170    /* UA,UG,C,A,G */+   230   280   230   250    /* UA,UG,C,A,U */+   230   280   230   250    /* UA,UG,C,C,A */+   230   280   230   250    /* UA,UG,C,C,C */+   230   280   230   250    /* UA,UG,C,C,G */+   230   280   230   250    /* UA,UG,C,C,U */+   260   370   260   340    /* UA,UG,C,G,A */+   230   280   230   250    /* UA,UG,C,G,C */+   100   150   100   120    /* UA,UG,C,G,G */+   230   280   230   250    /* UA,UG,C,G,U */+   230   280   230   250    /* UA,UG,C,U,A */+   230   280   230   250    /* UA,UG,C,U,C */+   230   280   230   250    /* UA,UG,C,U,G */+   230   280   230   250    /* UA,UG,C,U,U */+   140   240    90   240    /* UA,UG,G,A,A */+   170   280   120   280    /* UA,UG,G,A,C */+    40   140   120   140    /* UA,UG,G,A,G */+   170   280   120   280    /* UA,UG,G,A,U */+   170   280   120   280    /* UA,UG,G,C,A */+   230   280   120   280    /* UA,UG,G,C,C */+   170   280   120   280    /* UA,UG,G,C,G */+   230   280   120   280    /* UA,UG,G,C,U */+   200   310   280   310    /* UA,UG,G,G,A */+   170   280   120   280    /* UA,UG,G,G,C */+   170   150   250   150    /* UA,UG,G,G,G */+   170   280   120   280    /* UA,UG,G,G,U */+   170   280   120   280    /* UA,UG,G,U,A */+   230   280   120   280    /* UA,UG,G,U,C */+   170   280   120   280    /* UA,UG,G,U,G */+   170   280   250   280    /* UA,UG,G,U,U */+   200   240   200   220    /* UA,UG,U,A,A */+   230   280   230   190    /* UA,UG,U,A,C */+   100   200   100    60    /* UA,UG,U,A,G */+   230   280   230   190    /* UA,UG,U,A,U */+   230   280   230   190    /* UA,UG,U,C,A */+   230   280   230   190    /* UA,UG,U,C,C */+   230   280   230   190    /* UA,UG,U,C,G */+   230   280   230   190    /* UA,UG,U,C,U */+   260   370   260   220    /* UA,UG,U,G,A */+   230   280   230   190    /* UA,UG,U,G,C */+   100   150   100   190    /* UA,UG,U,G,G */+   230   280   230   190    /* UA,UG,U,G,U */+   230   280   230   190    /* UA,UG,U,U,A */+   230   280   230   190    /* UA,UG,U,U,C */+   230   280   230   190    /* UA,UG,U,U,G */+   230   280   230   190    /* UA,UG,U,U,U */+   280   280   180   280    /* UA,AU,A,A,A */+   250   250   160   250    /* UA,AU,A,A,C */+   150   150    60   150    /* UA,AU,A,A,G */+   250   250   160   250    /* UA,AU,A,A,U */+   260   260   170   260    /* UA,AU,A,C,A */+   260   260   220   260    /* UA,AU,A,C,C */+   260   260   170   260    /* UA,AU,A,C,G */+   260   260   220   260    /* UA,AU,A,C,U */+   220   220   130   220    /* UA,AU,A,G,A */+   250   250   160   250    /* UA,AU,A,G,C */+   100   100   140   100    /* UA,AU,A,G,G */+   250   250   160   250    /* UA,AU,A,G,U */+   260   260   170   260    /* UA,AU,A,U,A */+   260   260   220   260    /* UA,AU,A,U,C */+   260   260   170   260    /* UA,AU,A,U,G */+   230   170    70   170    /* UA,AU,A,U,U */+   230   280   230   250    /* UA,AU,C,A,A */+   210   250   210   220    /* UA,AU,C,A,C */+   110   210   110   180    /* UA,AU,C,A,G */+   210   250   210   220    /* UA,AU,C,A,U */+   220   260   220   230    /* UA,AU,C,C,A */+   210   260   210   230    /* UA,AU,C,C,C */+   220   260   220   230    /* UA,AU,C,C,G */+   210   260   210   230    /* UA,AU,C,C,U */+   180   280   180   250    /* UA,AU,C,G,A */+   210   250   210   220    /* UA,AU,C,G,C */+    60   100    60    70    /* UA,AU,C,G,G */+   210   250   210   220    /* UA,AU,C,G,U */+   220   260   220   230    /* UA,AU,C,U,A */+   210   260   210   230    /* UA,AU,C,U,C */+   220   260   220   230    /* UA,AU,C,U,G */+   120   170   120   140    /* UA,AU,C,U,U */+   170   280   120   280    /* UA,AU,G,A,A */+   150   250   100   250    /* UA,AU,G,A,C */+    50   150   130   150    /* UA,AU,G,A,G */+   150   250   100   250    /* UA,AU,G,A,U */+   160   260   110   260    /* UA,AU,G,C,A */+   210   260   100   260    /* UA,AU,G,C,C */+   160   260   110   260    /* UA,AU,G,C,G */+   210   260   100   260    /* UA,AU,G,C,U */+   120   220   200   220    /* UA,AU,G,G,A */+   150   250   100   250    /* UA,AU,G,G,C */+   130   100   210   100    /* UA,AU,G,G,G */+   150   250   100   250    /* UA,AU,G,G,U */+   160   260   110   260    /* UA,AU,G,U,A */+   210   260   100   260    /* UA,AU,G,U,C */+   160   260   110   260    /* UA,AU,G,U,G */+    60   170   140   170    /* UA,AU,G,U,U */+   230   280   230   250    /* UA,AU,U,A,A */+   210   250   210   170    /* UA,AU,U,A,C */+   110   210   110    70    /* UA,AU,U,A,G */+   210   250   210   170    /* UA,AU,U,A,U */+   220   260   220   180    /* UA,AU,U,C,A */+   210   260   210   170    /* UA,AU,U,C,C */+   220   260   220   180    /* UA,AU,U,C,G */+   210   260   210   170    /* UA,AU,U,C,U */+   180   280   180   140    /* UA,AU,U,G,A */+   210   250   210   170    /* UA,AU,U,G,C */+    60   100    60   150    /* UA,AU,U,G,G */+   210   250   210   170    /* UA,AU,U,G,U */+   220   260   220   180    /* UA,AU,U,U,A */+   210   260   210   170    /* UA,AU,U,U,C */+   220   260   220   180    /* UA,AU,U,U,G */+   120   170   120    80    /* UA,AU,U,U,U */+   280   280   180   280    /* UA,UA,A,A,A */+   230   230   140   230    /* UA,UA,A,A,C */+   170   170    80   170    /* UA,UA,A,A,G */+   230   230   140   230    /* UA,UA,A,A,U */+   280   280   180   280    /* UA,UA,A,C,A */+   280   280   240   280    /* UA,UA,A,C,C */+   280   280   180   280    /* UA,UA,A,C,G */+   280   280   240   280    /* UA,UA,A,C,U */+   180   180    90   180    /* UA,UA,A,G,A */+   230   230   140   230    /* UA,UA,A,G,C */+   120   120   160   120    /* UA,UA,A,G,G */+   230   230   140   230    /* UA,UA,A,G,U */+   280   280   180   280    /* UA,UA,A,U,A */+   250   250   210   250    /* UA,UA,A,U,C */+   280   280   180   280    /* UA,UA,A,U,G */+   250   190   100   190    /* UA,UA,A,U,U */+   230   280   230   250    /* UA,UA,C,A,A */+   190   230   190   200    /* UA,UA,C,A,C */+   130   230   130   200    /* UA,UA,C,A,G */+   190   230   190   200    /* UA,UA,C,A,U */+   230   280   230   250    /* UA,UA,C,C,A */+   230   280   230   250    /* UA,UA,C,C,C */+   230   280   230   250    /* UA,UA,C,C,G */+   230   280   230   250    /* UA,UA,C,C,U */+   140   240   140   210    /* UA,UA,C,G,A */+   190   230   190   200    /* UA,UA,C,G,C */+    80   120    80    90    /* UA,UA,C,G,G */+   190   230   190   200    /* UA,UA,C,G,U */+   230   280   230   250    /* UA,UA,C,U,A */+   200   250   200   220    /* UA,UA,C,U,C */+   230   280   230   250    /* UA,UA,C,U,G */+   150   190   150   160    /* UA,UA,C,U,U */+   170   280   120   280    /* UA,UA,G,A,A */+   130   230    80   230    /* UA,UA,G,A,C */+    70   170   150   170    /* UA,UA,G,A,G */+   130   230    80   230    /* UA,UA,G,A,U */+   170   280   120   280    /* UA,UA,G,C,A */+   230   280   120   280    /* UA,UA,G,C,C */+   170   280   120   280    /* UA,UA,G,C,G */+   230   280   120   280    /* UA,UA,G,C,U */+    80   180   160   180    /* UA,UA,G,G,A */+   130   230    80   230    /* UA,UA,G,G,C */+   150   120   230   120    /* UA,UA,G,G,G */+   130   230    80   230    /* UA,UA,G,G,U */+   170   280   120   280    /* UA,UA,G,U,A */+   200   250    90   250    /* UA,UA,G,U,C */+   170   280   120   280    /* UA,UA,G,U,G */+    90   190   170   190    /* UA,UA,G,U,U */+   230   280   230   250    /* UA,UA,U,A,A */+   190   230   190   150    /* UA,UA,U,A,C */+   130   230   130    90    /* UA,UA,U,A,G */+   190   230   190   150    /* UA,UA,U,A,U */+   230   280   230   190    /* UA,UA,U,C,A */+   230   280   230   190    /* UA,UA,U,C,C */+   230   280   230   190    /* UA,UA,U,C,G */+   230   280   230   190    /* UA,UA,U,C,U */+   140   240   140   100    /* UA,UA,U,G,A */+   190   230   190   150    /* UA,UA,U,G,C */+    80   120    80   170    /* UA,UA,U,G,G */+   190   230   190   150    /* UA,UA,U,G,U */+   230   280   230   190    /* UA,UA,U,U,A */+   200   250   200   160    /* UA,UA,U,U,C */+   230   280   230   190    /* UA,UA,U,U,G */+   150   190   150   110    /* UA,UA,U,U,U */++# int22_enthalpies+  -460  -310  -960  -310    /* CG,CG,A,A,A */+  -770  -620 -1270  -620    /* CG,CG,A,A,C */+  -670  -530 -1170  -530    /* CG,CG,A,A,G */+  -770  -620 -1270  -620    /* CG,CG,A,A,U */+  -310  -170  -810  -170    /* CG,CG,A,C,A */+  -320  -170  -580  -170    /* CG,CG,A,C,C */+  -310  -170  -810  -170    /* CG,CG,A,C,G */+  -370  -220  -630  -220    /* CG,CG,A,C,U */+  -960  -810 -1460  -810    /* CG,CG,A,G,A */+  -770  -620 -1270  -620    /* CG,CG,A,G,C */+  -120    30 -1870    30    /* CG,CG,A,G,G */+  -770  -620 -1270  -620    /* CG,CG,A,G,U */+  -310  -170  -810  -170    /* CG,CG,A,U,A */+  -260  -110  -520  -110    /* CG,CG,A,U,C */+  -310  -170  -810  -170    /* CG,CG,A,U,G */+  -860  -960 -1600  -960    /* CG,CG,A,U,U */+  -770  -320  -770  -260    /* CG,CG,C,A,A */+ -1080  -630 -1080  -570    /* CG,CG,C,A,C */+  -980  -290  -980  -230    /* CG,CG,C,A,G */+ -1080  -630 -1080  -570    /* CG,CG,C,A,U */+  -620  -170  -620  -110    /* CG,CG,C,C,A */+  -630  -180  -630  -120    /* CG,CG,C,C,C */+  -620  -170  -620  -110    /* CG,CG,C,C,G */+  -680  -230  -680  -170    /* CG,CG,C,C,U */+ -1270  -580 -1270  -520    /* CG,CG,C,G,A */+ -1080  -630 -1080  -570    /* CG,CG,C,G,C */+  -430    20  -430    80    /* CG,CG,C,G,G */+ -1080  -630 -1080  -570    /* CG,CG,C,G,U */+  -620  -170  -620  -110    /* CG,CG,C,U,A */+  -570  -120  -570   -60    /* CG,CG,C,U,C */+  -620  -170  -620  -110    /* CG,CG,C,U,G */+ -1410  -960 -1410  -900    /* CG,CG,C,U,U */+  -670  -310  -120  -310    /* CG,CG,G,A,A */+  -980  -620  -430  -620    /* CG,CG,G,A,C */+  -890  -530 -1580  -530    /* CG,CG,G,A,G */+  -980  -620  -430  -620    /* CG,CG,G,A,U */+  -530  -170    30  -170    /* CG,CG,G,C,A */+  -290  -170    20  -170    /* CG,CG,G,C,C */+  -530  -170    30  -170    /* CG,CG,G,C,G */+  -340  -220   -30  -220    /* CG,CG,G,C,U */+ -1170  -810 -1870  -810    /* CG,CG,G,G,A */+  -980  -620  -430  -620    /* CG,CG,G,G,C */+ -1580    30 -2280    30    /* CG,CG,G,G,G */+  -980  -620  -430  -620    /* CG,CG,G,G,U */+  -530  -170    30  -170    /* CG,CG,G,U,A */+  -230  -110    80  -110    /* CG,CG,G,U,C */+  -530  -170    30  -170    /* CG,CG,G,U,G */+ -1320  -960 -2010  -960    /* CG,CG,G,U,U */+  -770  -370  -770  -860    /* CG,CG,U,A,A */+ -1080  -680 -1080 -1410    /* CG,CG,U,A,C */+  -980  -340  -980 -1320    /* CG,CG,U,A,G */+ -1080  -680 -1080 -1410    /* CG,CG,U,A,U */+  -620  -220  -620  -960    /* CG,CG,U,C,A */+  -630  -230  -630  -960    /* CG,CG,U,C,C */+  -620  -220  -620  -960    /* CG,CG,U,C,G */+  -680  -280  -680 -1010    /* CG,CG,U,C,U */+ -1270  -630 -1270 -1600    /* CG,CG,U,G,A */+ -1080  -680 -1080 -1410    /* CG,CG,U,G,C */+  -430   -30  -430 -2010    /* CG,CG,U,G,G */+ -1080  -680 -1080 -1410    /* CG,CG,U,G,U */+  -620  -220  -620  -960    /* CG,CG,U,U,A */+  -570  -170  -570  -900    /* CG,CG,U,U,C */+  -620  -220  -620  -960    /* CG,CG,U,U,G */+ -1410 -1010 -1410 -1750    /* CG,CG,U,U,U */+  -580  -220  -970  -150    /* CG,GC,A,A,A */+  -740  -600  -100  -600    /* CG,GC,A,A,C */+ -2010 -1650 -1980 -1340    /* CG,GC,A,A,G */+  -740  -600 -1240  -600    /* CG,GC,A,A,U */+  -660 -1150    10  -510    /* CG,GC,A,C,A */+  -960  -820   540  -820    /* CG,GC,A,C,C */+  -660  -510 -1160  -510    /* CG,GC,A,C,G */+  -960  -820 -1220  -820    /* CG,GC,A,C,U */+ -1340  -860 -2450  -860    /* CG,GC,A,G,A */+  -740  -600 -1240  -600    /* CG,GC,A,G,C */+   180  -390 -1870    30    /* CG,GC,A,G,G */+  -740  -600 -1240  -600    /* CG,GC,A,G,U */+  -660  -510 -1160  -510    /* CG,GC,A,U,A */+ -1270 -1130 -1530 -1130    /* CG,GC,A,U,C */+  -660  -510 -1160  -510    /* CG,GC,A,U,G */+ -1240   -90  -810  -800    /* CG,GC,A,U,U */+  -600 -1070  -600   -90    /* CG,GC,C,A,A */+ -1050  -600 -1050  -540    /* CG,GC,C,A,C */+ -1790  -630 -1790 -1040    /* CG,GC,C,A,G */+ -1050  -600 -1050  -540    /* CG,GC,C,A,U */+  -970  -750  -970  -460    /* CG,GC,C,C,A */+ -1270  -820 -1270  -760    /* CG,GC,C,C,C */+  -970  -520  -970  -460    /* CG,GC,C,C,G */+ -1270  -820 -1270  -550    /* CG,GC,C,C,U */+ -1070  -500 -1320  -570    /* CG,GC,C,G,A */+ -1050  -600 -1050  -540    /* CG,GC,C,G,C */+  -430    20  -430   180    /* CG,GC,C,G,G */+ -1050  -600 -1050  -540    /* CG,GC,C,G,U */+  -970  -520  -970  -460    /* CG,GC,C,U,A */+ -1580 -1130 -1580 -1070    /* CG,GC,C,U,C */+  -970  -520  -970  -460    /* CG,GC,C,U,G */+  -830 -1710 -1260 -1460    /* CG,GC,C,U,U */+ -1600  -150  -200  -150    /* CG,GC,G,A,A */+  -350  -600  -440  -600    /* CG,GC,G,A,C */+ -3070 -1340 -2390 -1340    /* CG,GC,G,A,G */+  -960  -600  -400  -600    /* CG,GC,G,A,U */+ -1110  -510  -320  -510    /* CG,GC,G,C,A */+  -940  -820  -620  -820    /* CG,GC,G,C,C */+  -870  -510  -320  -510    /* CG,GC,G,C,G */+  -940  -820  -260  -820    /* CG,GC,G,C,U */+ -1880  -860 -1080  -860    /* CG,GC,G,G,A */+  -960  -600  -400  -600    /* CG,GC,G,G,C */+ -1370    30 -2280    30    /* CG,GC,G,G,G */+  -960  -600  -400  -600    /* CG,GC,G,G,U */+  -870  -510  -320  -510    /* CG,GC,G,U,A */+ -1250 -1130  -210 -1130    /* CG,GC,G,U,C */+  -870  -510  -320  -510    /* CG,GC,G,U,G */+ -1360  -800 -1550  -800    /* CG,GC,G,U,U */+  -600  -200  -600 -1490    /* CG,GC,U,A,A */+ -1050  -650 -1050 -1390    /* CG,GC,U,A,C */+ -1790 -1150 -1790 -1520    /* CG,GC,U,A,G */+ -1050  -650 -1050 -1390    /* CG,GC,U,A,U */+  -970  -570  -970  -400    /* CG,GC,U,C,A */+ -1270  -870 -1270 -1610    /* CG,GC,U,C,C */+  -970  -570  -970 -1300    /* CG,GC,U,C,G */+ -1270  -870 -1270 -1610    /* CG,GC,U,C,U */+ -1320 -1750 -1320 -1300    /* CG,GC,U,G,A */+ -1050  -650 -1050 -1390    /* CG,GC,U,G,C */+  -430  -880  -430  -230    /* CG,GC,U,G,G */+ -1050  -650 -1050 -1390    /* CG,GC,U,G,U */+  -970  -570  -970 -1300    /* CG,GC,U,U,A */+ -1580 -1180 -1580 -1920    /* CG,GC,U,U,C */+  -970  -570  -970 -1300    /* CG,GC,U,U,G */+ -1260  -860 -1260 -2350    /* CG,GC,U,U,U */+ -1370 -1240 -1890 -1240    /* CG,GU,A,A,A */+ -1210 -1060 -1710 -1060    /* CG,GU,A,A,C */+ -1220 -1080 -1720 -1080    /* CG,GU,A,A,G */+ -1210 -1060 -1710 -1060    /* CG,GU,A,A,U */+ -1210 -1060 -1710 -1060    /* CG,GU,A,C,A */+ -1210 -1060 -1470 -1060    /* CG,GU,A,C,C */+ -1210 -1060 -1710 -1060    /* CG,GU,A,C,G */+ -1210 -1060 -1470 -1060    /* CG,GU,A,C,U */+ -1030  -890 -1530  -890    /* CG,GU,A,G,A */+ -1210 -1060 -1710 -1060    /* CG,GU,A,G,C */+    40   190 -1710   190    /* CG,GU,A,G,G */+ -1210 -1060 -1710 -1060    /* CG,GU,A,G,U */+ -1210 -1060 -1710 -1060    /* CG,GU,A,U,A */+ -1210 -1060 -1470 -1060    /* CG,GU,A,U,C */+ -1210 -1060 -1710 -1060    /* CG,GU,A,U,G */+  -970 -1060 -1710 -1060    /* CG,GU,A,U,U */+ -1700 -1250 -1700 -1190    /* CG,GU,C,A,A */+ -1520 -1070 -1520 -1010    /* CG,GU,C,A,C */+ -1530  -840 -1530  -780    /* CG,GU,C,A,G */+ -1520 -1070 -1520 -1010    /* CG,GU,C,A,U */+ -1520 -1070 -1520 -1010    /* CG,GU,C,C,A */+ -1520 -1070 -1520 -1010    /* CG,GU,C,C,C */+ -1520 -1070 -1520 -1010    /* CG,GU,C,C,G */+ -1520 -1070 -1520 -1010    /* CG,GU,C,C,U */+ -1340  -650 -1340  -590    /* CG,GU,C,G,A */+ -1520 -1070 -1520 -1010    /* CG,GU,C,G,C */+  -270   180  -270   240    /* CG,GU,C,G,G */+ -1520 -1070 -1520 -1010    /* CG,GU,C,G,U */+ -1520 -1070 -1520 -1010    /* CG,GU,C,U,A */+ -1520 -1070 -1520 -1010    /* CG,GU,C,U,C */+ -1520 -1070 -1520 -1010    /* CG,GU,C,U,G */+ -1520 -1070 -1520 -1010    /* CG,GU,C,U,U */+ -1600 -1240 -1050 -1240    /* CG,GU,G,A,A */+ -1420 -1060  -870 -1060    /* CG,GU,G,A,C */+ -1440 -1080 -2130 -1080    /* CG,GU,G,A,G */+ -1420 -1060  -870 -1060    /* CG,GU,G,A,U */+ -1420 -1060  -870 -1060    /* CG,GU,G,C,A */+ -1180 -1060  -870 -1060    /* CG,GU,G,C,C */+ -1420 -1060  -870 -1060    /* CG,GU,G,C,G */+ -1180 -1060  -870 -1060    /* CG,GU,G,C,U */+ -1250  -890 -1940  -890    /* CG,GU,G,G,A */+ -1420 -1060  -870 -1060    /* CG,GU,G,G,C */+ -1420   190 -2120   190    /* CG,GU,G,G,G */+ -1420 -1060  -870 -1060    /* CG,GU,G,G,U */+ -1420 -1060  -870 -1060    /* CG,GU,G,U,A */+ -1180 -1060  -870 -1060    /* CG,GU,G,U,C */+ -1420 -1060  -870 -1060    /* CG,GU,G,U,G */+ -1420 -1060 -2120 -1060    /* CG,GU,G,U,U */+ -1700 -1300 -1700 -1790    /* CG,GU,U,A,A */+ -1520 -1120 -1520 -1850    /* CG,GU,U,A,C */+ -1530  -890 -1530 -1870    /* CG,GU,U,A,G */+ -1520 -1120 -1520 -1850    /* CG,GU,U,A,U */+ -1520 -1120 -1520 -1850    /* CG,GU,U,C,A */+ -1520 -1120 -1520 -1850    /* CG,GU,U,C,C */+ -1520 -1120 -1520 -1850    /* CG,GU,U,C,G */+ -1520 -1120 -1520 -1850    /* CG,GU,U,C,U */+ -1340  -700 -1340 -1680    /* CG,GU,U,G,A */+ -1520 -1120 -1520 -1850    /* CG,GU,U,G,C */+  -270   130  -270 -1850    /* CG,GU,U,G,G */+ -1520 -1120 -1520 -1850    /* CG,GU,U,G,U */+ -1520 -1120 -1520 -1850    /* CG,GU,U,U,A */+ -1520 -1120 -1520 -1850    /* CG,GU,U,U,C */+ -1520 -1120 -1520 -1850    /* CG,GU,U,U,G */+ -1520 -1120 -1520 -1850    /* CG,GU,U,U,U */+  -140     0  -640     0    /* CG,UG,A,A,A */+  -650  -510 -1150  -510    /* CG,UG,A,A,C */+  -990  -850 -1490  -850    /* CG,UG,A,A,G */+  -650  -510 -1150  -510    /* CG,UG,A,A,U */+  -650  -510 -1150  -510    /* CG,UG,A,C,A */+  -650  -510  -910  -510    /* CG,UG,A,C,C */+  -650  -510 -1150  -510    /* CG,UG,A,C,G */+  -650  -510  -910  -510    /* CG,UG,A,C,U */+ -1160 -1020 -1660 -1020    /* CG,UG,A,G,A */+  -650  -510 -1150  -510    /* CG,UG,A,G,C */+   600   740 -1150   740    /* CG,UG,A,G,G */+  -650  -510 -1150  -510    /* CG,UG,A,G,U */+  -650  -510 -1150  -510    /* CG,UG,A,U,A */+  -650  -510  -910  -510    /* CG,UG,A,U,C */+  -650  -510 -1150  -510    /* CG,UG,A,U,G */+  -410  -510 -1150  -510    /* CG,UG,A,U,U */+  -450     0  -450    50    /* CG,UG,C,A,A */+  -960  -510  -960  -450    /* CG,UG,C,A,C */+ -1300  -610 -1300  -550    /* CG,UG,C,A,G */+  -960  -510  -960  -450    /* CG,UG,C,A,U */+  -960  -510  -960  -450    /* CG,UG,C,C,A */+  -960  -510  -960  -450    /* CG,UG,C,C,C */+  -960  -510  -960  -450    /* CG,UG,C,C,G */+  -960  -510  -960  -450    /* CG,UG,C,C,U */+ -1470  -780 -1470  -720    /* CG,UG,C,G,A */+  -960  -510  -960  -450    /* CG,UG,C,G,C */+   290   740   290   800    /* CG,UG,C,G,G */+  -960  -510  -960  -450    /* CG,UG,C,G,U */+  -960  -510  -960  -450    /* CG,UG,C,U,A */+  -960  -510  -960  -450    /* CG,UG,C,U,C */+  -960  -510  -960  -450    /* CG,UG,C,U,G */+  -960  -510  -960  -450    /* CG,UG,C,U,U */+  -360     0   200     0    /* CG,UG,G,A,A */+  -870  -510  -310  -510    /* CG,UG,G,A,C */+ -1210  -850 -1900  -850    /* CG,UG,G,A,G */+  -870  -510  -310  -510    /* CG,UG,G,A,U */+  -870  -510  -310  -510    /* CG,UG,G,C,A */+  -630  -510  -310  -510    /* CG,UG,G,C,C */+  -870  -510  -310  -510    /* CG,UG,G,C,G */+  -630  -510  -310  -510    /* CG,UG,G,C,U */+ -1380 -1020 -2070 -1020    /* CG,UG,G,G,A */+  -870  -510  -310  -510    /* CG,UG,G,G,C */+  -870   740 -1560   740    /* CG,UG,G,G,G */+  -870  -510  -310  -510    /* CG,UG,G,G,U */+  -870  -510  -310  -510    /* CG,UG,G,U,A */+  -630  -510  -310  -510    /* CG,UG,G,U,C */+  -870  -510  -310  -510    /* CG,UG,G,U,G */+  -870  -510 -1560  -510    /* CG,UG,G,U,U */+  -450   -50  -450  -550    /* CG,UG,U,A,A */+  -960  -560  -960 -1300    /* CG,UG,U,A,C */+ -1300  -660 -1300 -1640    /* CG,UG,U,A,G */+  -960  -560  -960 -1300    /* CG,UG,U,A,U */+  -960  -560  -960 -1300    /* CG,UG,U,C,A */+  -960  -560  -960 -1300    /* CG,UG,U,C,C */+  -960  -560  -960 -1300    /* CG,UG,U,C,G */+  -960  -560  -960 -1300    /* CG,UG,U,C,U */+ -1470  -830 -1470 -1810    /* CG,UG,U,G,A */+  -960  -560  -960 -1300    /* CG,UG,U,G,C */+   290   690   290 -1300    /* CG,UG,U,G,G */+  -960  -560  -960 -1300    /* CG,UG,U,G,U */+  -960  -560  -960 -1300    /* CG,UG,U,U,A */+  -960  -560  -960 -1300    /* CG,UG,U,U,C */+  -960  -560  -960 -1300    /* CG,UG,U,U,G */+  -960  -560  -960 -1300    /* CG,UG,U,U,U */+   440   580   -60   580    /* CG,AU,A,A,A */+   130   270  -370   270    /* CG,AU,A,A,C */+  -950  -800 -1450  -800    /* CG,AU,A,A,G */+   130   270  -370   270    /* CG,AU,A,A,U */+   140   290  -350   290    /* CG,AU,A,C,A */+   140   280  -120   280    /* CG,AU,A,C,C */+   140   290  -350   290    /* CG,AU,A,C,G */+   140   280  -120   280    /* CG,AU,A,C,U */+  -770  -620 -1270  -620    /* CG,AU,A,G,A */+   130   270  -370   270    /* CG,AU,A,G,C */+   970  1120  -780  1120    /* CG,AU,A,G,G */+   130   270  -370   270    /* CG,AU,A,G,U */+   140   290  -350   290    /* CG,AU,A,U,A */+   140   280  -120   280    /* CG,AU,A,U,C */+   140   290  -350   290    /* CG,AU,A,U,G */+  -600  -690 -1340  -690    /* CG,AU,A,U,U */+   130   580   130   640    /* CG,AU,C,A,A */+  -180   270  -180   330    /* CG,AU,C,A,C */+ -1260  -570 -1260  -510    /* CG,AU,C,A,G */+  -180   270  -180   330    /* CG,AU,C,A,U */+  -160   280  -160   340    /* CG,AU,C,C,A */+  -170   280  -170   340    /* CG,AU,C,C,C */+  -160   280  -160   340    /* CG,AU,C,C,G */+  -170   280  -170   340    /* CG,AU,C,C,U */+ -1080  -390 -1080  -330    /* CG,AU,C,G,A */+  -180   270  -180   330    /* CG,AU,C,G,C */+   660  1110   660  1170    /* CG,AU,C,G,G */+  -180   270  -180   330    /* CG,AU,C,G,U */+  -160   280  -160   340    /* CG,AU,C,U,A */+  -170   280  -170   340    /* CG,AU,C,U,C */+  -160   280  -160   340    /* CG,AU,C,U,G */+ -1150  -700 -1150  -640    /* CG,AU,C,U,U */+   220   580   780   580    /* CG,AU,G,A,A */+   -80   270   470   270    /* CG,AU,G,A,C */+ -1160  -800 -1860  -800    /* CG,AU,G,A,G */+   -80   270   470   270    /* CG,AU,G,A,U */+   -70   290   490   290    /* CG,AU,G,C,A */+   170   280   480   280    /* CG,AU,G,C,C */+   -70   290   490   290    /* CG,AU,G,C,G */+   170   280   480   280    /* CG,AU,G,C,U */+  -980  -620 -1680  -620    /* CG,AU,G,G,A */+   -80   270   470   270    /* CG,AU,G,G,C */+  -490  1120 -1190  1120    /* CG,AU,G,G,G */+   -80   270   470   270    /* CG,AU,G,G,U */+   -70   290   490   290    /* CG,AU,G,U,A */+   170   280   480   280    /* CG,AU,G,U,C */+   -70   290   490   290    /* CG,AU,G,U,G */+ -1050  -690 -1750  -690    /* CG,AU,G,U,U */+   130   530   130    40    /* CG,AU,U,A,A */+  -180   220  -180  -510    /* CG,AU,U,A,C */+ -1260  -620 -1260 -1590    /* CG,AU,U,A,G */+  -180   220  -180  -510    /* CG,AU,U,A,U */+  -160   230  -160  -500    /* CG,AU,U,C,A */+  -170   230  -170  -500    /* CG,AU,U,C,C */+  -160   230  -160  -500    /* CG,AU,U,C,G */+  -170   230  -170  -500    /* CG,AU,U,C,U */+ -1080  -440 -1080 -1410    /* CG,AU,U,G,A */+  -180   220  -180  -510    /* CG,AU,U,G,C */+   660  1060   660  -920    /* CG,AU,U,G,G */+  -180   220  -180  -510    /* CG,AU,U,G,U */+  -160   230  -160  -500    /* CG,AU,U,U,A */+  -170   230  -170  -500    /* CG,AU,U,U,C */+  -160   230  -160  -500    /* CG,AU,U,U,G */+ -1150  -750 -1150 -1480    /* CG,AU,U,U,U */+   500   650     0   650    /* CG,UA,A,A,A */+   220   370  -270   370    /* CG,UA,A,A,C */+  -900  -750 -1400  -750    /* CG,UA,A,A,G */+   220   370  -270   370    /* CG,UA,A,A,U */+   370   520  -120   520    /* CG,UA,A,C,A */+   370   520   120   520    /* CG,UA,A,C,C */+   370   520  -120   520    /* CG,UA,A,C,G */+   240   390   -10   390    /* CG,UA,A,C,U */+ -1200 -1050 -1700 -1050    /* CG,UA,A,G,A */+   220   370  -270   370    /* CG,UA,A,G,C */+  1160  1300  -590  1300    /* CG,UA,A,G,G */+   220   370  -270   370    /* CG,UA,A,G,U */+   370   520  -120   520    /* CG,UA,A,U,A */+   -60    80  -320    80    /* CG,UA,A,U,C */+   370   520  -120   520    /* CG,UA,A,U,G */+  -320  -420 -1060  -420    /* CG,UA,A,U,U */+   190   640   190   700    /* CG,UA,C,A,A */+   -80   360   -80   420    /* CG,UA,C,A,C */+ -1210  -520 -1210  -460    /* CG,UA,C,A,G */+   -80   360   -80   420    /* CG,UA,C,A,U */+    60   510    60   570    /* CG,UA,C,C,A */+    60   510    60   570    /* CG,UA,C,C,C */+    60   510    60   570    /* CG,UA,C,C,G */+   -60   380   -60   440    /* CG,UA,C,C,U */+ -1510  -820 -1510  -760    /* CG,UA,C,G,A */+   -80   360   -80   420    /* CG,UA,C,G,C */+   850  1290   850  1350    /* CG,UA,C,G,G */+   -80   360   -80   420    /* CG,UA,C,G,U */+    60   510    60   570    /* CG,UA,C,U,A */+  -370    70  -370   130    /* CG,UA,C,U,C */+    60   510    60   570    /* CG,UA,C,U,G */+  -870  -420  -870  -360    /* CG,UA,C,U,U */+   290   650   850   650    /* CG,UA,G,A,A */+    10   370   570   370    /* CG,UA,G,A,C */+ -1110  -750 -1810  -750    /* CG,UA,G,A,G */+    10   370   570   370    /* CG,UA,G,A,U */+   160   520   720   520    /* CG,UA,G,C,A */+   400   520   720   520    /* CG,UA,G,C,C */+   160   520   720   520    /* CG,UA,G,C,G */+   270   390   590   390    /* CG,UA,G,C,U */+ -1410 -1050 -2110 -1050    /* CG,UA,G,G,A */+    10   370   570   370    /* CG,UA,G,G,C */+  -310  1300 -1000  1300    /* CG,UA,G,G,G */+    10   370   570   370    /* CG,UA,G,G,U */+   160   520   720   520    /* CG,UA,G,U,A */+   -40    80   280    80    /* CG,UA,G,U,C */+   160   520   720   520    /* CG,UA,G,U,G */+  -780  -420 -1470  -420    /* CG,UA,G,U,U */+   190   590   190   100    /* CG,UA,U,A,A */+   -80   310   -80  -420    /* CG,UA,U,A,C */+ -1210  -570 -1210 -1540    /* CG,UA,U,A,G */+   -80   310   -80  -420    /* CG,UA,U,A,U */+    60   460    60  -270    /* CG,UA,U,C,A */+    60   460    60  -270    /* CG,UA,U,C,C */+    60   460    60  -270    /* CG,UA,U,C,G */+   -60   330   -60  -400    /* CG,UA,U,C,U */+ -1510  -870 -1510 -1840    /* CG,UA,U,G,A */+   -80   310   -80  -420    /* CG,UA,U,G,C */+   850  1250   850  -740    /* CG,UA,U,G,G */+   -80   310   -80  -420    /* CG,UA,U,G,U */+    60   460    60  -270    /* CG,UA,U,U,A */+  -370    20  -370  -710    /* CG,UA,U,U,C */+    60   460    60  -270    /* CG,UA,U,U,G */+  -870  -470  -870 -1210    /* CG,UA,U,U,U */+  -580  -660 -1340  -660    /* GC,CG,A,A,A */+  -600  -970 -1070  -970    /* GC,CG,A,A,C */+ -1600 -1110 -1880  -870    /* GC,CG,A,A,G */+  -600  -970 -1320  -970    /* GC,CG,A,A,U */+  -220 -1150  -860  -510    /* GC,CG,A,C,A */+ -1070  -750  -500  -520    /* GC,CG,A,C,C */+  -150  -510  -860  -510    /* GC,CG,A,C,G */+  -200  -570 -1750  -570    /* GC,CG,A,C,U */+  -970    10 -2450 -1160    /* GC,CG,A,G,A */+  -600  -970 -1320  -970    /* GC,CG,A,G,C */+  -200  -320 -1080  -320    /* GC,CG,A,G,G */+  -600  -970 -1320  -970    /* GC,CG,A,G,U */+  -150  -510  -860  -510    /* GC,CG,A,U,A */+   -90  -460  -570  -460    /* GC,CG,A,U,C */+  -150  -510  -860  -510    /* GC,CG,A,U,G */+ -1490  -400 -1300 -1300    /* GC,CG,A,U,U */+  -740  -960  -740 -1270    /* GC,CG,C,A,A */+ -1050 -1270 -1050 -1580    /* GC,CG,C,A,C */+  -350  -940  -960 -1250    /* GC,CG,C,A,G */+ -1050 -1270 -1050 -1580    /* GC,CG,C,A,U */+  -600  -820  -600 -1130    /* GC,CG,C,C,A */+  -600  -820  -600 -1130    /* GC,CG,C,C,C */+  -600  -820  -600 -1130    /* GC,CG,C,C,G */+  -650  -870  -650 -1180    /* GC,CG,C,C,U */+  -100   540 -1240 -1530    /* GC,CG,C,G,A */+ -1050 -1270 -1050 -1580    /* GC,CG,C,G,C */+  -440  -620  -400  -210    /* GC,CG,C,G,G */+ -1050 -1270 -1050 -1580    /* GC,CG,C,G,U */+  -600  -820  -600 -1130    /* GC,CG,C,U,A */+  -540  -760  -540 -1070    /* GC,CG,C,U,C */+  -600  -820  -600 -1130    /* GC,CG,C,U,G */+ -1390 -1610 -1390 -1920    /* GC,CG,C,U,U */+ -2010  -660   180  -660    /* GC,CG,G,A,A */+ -1790  -970  -430  -970    /* GC,CG,G,A,C */+ -3070  -870 -1370  -870    /* GC,CG,G,A,G */+ -1790  -970  -430  -970    /* GC,CG,G,A,U */+ -1650  -510  -390  -510    /* GC,CG,G,C,A */+  -630  -520    20  -520    /* GC,CG,G,C,C */+ -1340  -510    30  -510    /* GC,CG,G,C,G */+ -1150  -570  -880  -570    /* GC,CG,G,C,U */+ -1980 -1160 -1870 -1160    /* GC,CG,G,G,A */+ -1790  -970  -430  -970    /* GC,CG,G,G,C */+ -2390  -320 -2280  -320    /* GC,CG,G,G,G */+ -1790  -970  -430  -970    /* GC,CG,G,G,U */+ -1340  -510    30  -510    /* GC,CG,G,U,A */+ -1040  -460   180  -460    /* GC,CG,G,U,C */+ -1340  -510    30  -510    /* GC,CG,G,U,G */+ -1520 -1300  -230 -1300    /* GC,CG,G,U,U */+  -740  -960  -740 -1240    /* GC,CG,U,A,A */+ -1050 -1270 -1050  -830    /* GC,CG,U,A,C */+  -960  -940  -960 -1360    /* GC,CG,U,A,G */+ -1050 -1270 -1050 -1260    /* GC,CG,U,A,U */+  -600  -820  -600   -90    /* GC,CG,U,C,A */+  -600  -820  -600 -1710    /* GC,CG,U,C,C */+  -600  -820  -600  -800    /* GC,CG,U,C,G */+  -650  -870  -650  -860    /* GC,CG,U,C,U */+ -1240 -1220 -1240  -810    /* GC,CG,U,G,A */+ -1050 -1270 -1050 -1260    /* GC,CG,U,G,C */+  -400  -260  -400 -1550    /* GC,CG,U,G,G */+ -1050 -1270 -1050 -1260    /* GC,CG,U,G,U */+  -600  -820  -600  -800    /* GC,CG,U,U,A */+  -540  -550  -540 -1460    /* GC,CG,U,U,C */+  -600  -820  -600  -800    /* GC,CG,U,U,G */+ -1390 -1610 -1390 -2350    /* GC,CG,U,U,U */+  -130  -490  -840  -490    /* GC,GC,A,A,A */+  -580  -940 -1290  -940    /* GC,GC,A,A,C */+ -1320 -1680 -2030 -1680    /* GC,GC,A,A,G */+  -580  -940 -1290  -940    /* GC,GC,A,A,U */+  -490  -860 -1210  -860    /* GC,GC,A,C,A */+  -800 -1160 -1270 -1160    /* GC,GC,A,C,C */+  -490  -860 -1210  -860    /* GC,GC,A,C,G */+  -800 -1160 -1270 -1160    /* GC,GC,A,C,U */+  -840 -1210 -1560 -1210    /* GC,GC,A,G,A */+  -580  -940 -1290  -940    /* GC,GC,A,G,C */+    50  -320 -1920  -320    /* GC,GC,A,G,G */+  -580  -940 -1290  -940    /* GC,GC,A,G,U */+  -490  -860 -1210  -860    /* GC,GC,A,U,A */+ -1110 -1470 -1580 -1470    /* GC,GC,A,U,C */+  -490  -860 -1210  -860    /* GC,GC,A,U,G */+  -540 -1150 -1500 -1150    /* GC,GC,A,U,U */+  -580  -800  -580 -1110    /* GC,GC,C,A,A */+ -1030 -1250 -1030 -1560    /* GC,GC,C,A,C */+ -1770 -1750 -1770 -2060    /* GC,GC,C,A,G */+ -1030 -1250 -1030 -1560    /* GC,GC,C,A,U */+  -940 -1160  -940 -1470    /* GC,GC,C,C,A */+ -1250 -1470 -1250 -1780    /* GC,GC,C,C,C */+  -940 -1160  -940 -1470    /* GC,GC,C,C,G */+ -1250 -1470 -1250 -1780    /* GC,GC,C,C,U */+ -1290 -1270 -1290 -1580    /* GC,GC,C,G,A */+ -1030 -1250 -1030 -1560    /* GC,GC,C,G,C */+  -400  -620  -400  -930    /* GC,GC,C,G,G */+ -1030 -1250 -1030 -1560    /* GC,GC,C,G,U */+  -940 -1160  -940 -1470    /* GC,GC,C,U,A */+ -1560 -1780 -1560 -2090    /* GC,GC,C,U,C */+  -940 -1160  -940 -1470    /* GC,GC,C,U,G */+ -1230 -1450 -1230 -1760    /* GC,GC,C,U,U */+ -1320  -490    50  -490    /* GC,GC,G,A,A */+ -1770  -940  -400  -940    /* GC,GC,G,A,C */+ -2510 -1680 -2390 -1680    /* GC,GC,G,A,G */+ -1770  -940  -400  -940    /* GC,GC,G,A,U */+ -1680  -860  -320  -860    /* GC,GC,G,C,A */+ -1750 -1160  -620 -1160    /* GC,GC,G,C,C */+ -1680  -860  -320  -860    /* GC,GC,G,C,G */+ -1750 -1160  -620 -1160    /* GC,GC,G,C,U */+ -2030 -1210 -1920 -1210    /* GC,GC,G,G,A */+ -1770  -940  -400  -940    /* GC,GC,G,G,C */+ -2390  -320 -2280  -320    /* GC,GC,G,G,G */+ -1770  -940  -400  -940    /* GC,GC,G,G,U */+ -1680  -860  -320  -860    /* GC,GC,G,U,A */+ -2060 -1470  -930 -1470    /* GC,GC,G,U,C */+ -1680  -860  -320  -860    /* GC,GC,G,U,G */+ -1970 -1150 -1860 -1150    /* GC,GC,G,U,U */+  -580  -800  -580  -540    /* GC,GC,U,A,A */+ -1030 -1250 -1030 -1230    /* GC,GC,U,A,C */+ -1770 -1750 -1770 -1970    /* GC,GC,U,A,G */+ -1030 -1250 -1030 -1230    /* GC,GC,U,A,U */+  -940 -1160  -940 -1150    /* GC,GC,U,C,A */+ -1250 -1470 -1250 -1450    /* GC,GC,U,C,C */+  -940 -1160  -940 -1150    /* GC,GC,U,C,G */+ -1250 -1470 -1250 -1450    /* GC,GC,U,C,U */+ -1290 -1270 -1290 -1500    /* GC,GC,U,G,A */+ -1030 -1250 -1030 -1230    /* GC,GC,U,G,C */+  -400  -620  -400 -1860    /* GC,GC,U,G,G */+ -1030 -1250 -1030 -1230    /* GC,GC,U,G,U */+  -940 -1160  -940 -1150    /* GC,GC,U,U,A */+ -1560 -1780 -1560 -1760    /* GC,GC,U,U,C */+  -940 -1160  -940 -1150    /* GC,GC,U,U,G */+ -1230 -1450 -1230 -1440    /* GC,GC,U,U,U */+ -1220 -1590 -1940 -1590    /* GC,GU,A,A,A */+ -1040 -1410 -1760 -1410    /* GC,GU,A,A,C */+ -1060 -1420 -1770 -1420    /* GC,GU,A,A,G */+ -1040 -1410 -1760 -1410    /* GC,GU,A,A,U */+ -1040 -1410 -1760 -1410    /* GC,GU,A,C,A */+ -1040 -1410 -1520 -1410    /* GC,GU,A,C,C */+ -1040 -1410 -1760 -1410    /* GC,GU,A,C,G */+ -1040 -1410 -1520 -1410    /* GC,GU,A,C,U */+  -870 -1230 -1580 -1230    /* GC,GU,A,G,A */+ -1040 -1410 -1760 -1410    /* GC,GU,A,G,C */+   210  -160 -1760  -160    /* GC,GU,A,G,G */+ -1040 -1410 -1760 -1410    /* GC,GU,A,G,U */+ -1040 -1410 -1760 -1410    /* GC,GU,A,U,A */+ -1040 -1410 -1520 -1410    /* GC,GU,A,U,C */+ -1040 -1410 -1760 -1410    /* GC,GU,A,U,G */+  -800 -1410 -1760 -1410    /* GC,GU,A,U,U */+ -1670 -1890 -1670 -2200    /* GC,GU,C,A,A */+ -1490 -1710 -1490 -2020    /* GC,GU,C,A,C */+ -1510 -1490 -1510 -1800    /* GC,GU,C,A,G */+ -1490 -1710 -1490 -2020    /* GC,GU,C,A,U */+ -1490 -1710 -1490 -2020    /* GC,GU,C,C,A */+ -1490 -1710 -1490 -2020    /* GC,GU,C,C,C */+ -1490 -1710 -1490 -2020    /* GC,GU,C,C,G */+ -1490 -1710 -1490 -2020    /* GC,GU,C,C,U */+ -1320 -1300 -1320 -1610    /* GC,GU,C,G,A */+ -1490 -1710 -1490 -2020    /* GC,GU,C,G,C */+  -240  -460  -240  -770    /* GC,GU,C,G,G */+ -1490 -1710 -1490 -2020    /* GC,GU,C,G,U */+ -1490 -1710 -1490 -2020    /* GC,GU,C,U,A */+ -1490 -1710 -1490 -2020    /* GC,GU,C,U,C */+ -1490 -1710 -1490 -2020    /* GC,GU,C,U,G */+ -1490 -1710 -1490 -2020    /* GC,GU,C,U,U */+ -2410 -1590 -1050 -1590    /* GC,GU,G,A,A */+ -2230 -1410  -870 -1410    /* GC,GU,G,A,C */+ -2250 -1420 -2130 -1420    /* GC,GU,G,A,G */+ -2230 -1410  -870 -1410    /* GC,GU,G,A,U */+ -2230 -1410  -870 -1410    /* GC,GU,G,C,A */+ -1990 -1410  -870 -1410    /* GC,GU,G,C,C */+ -2230 -1410  -870 -1410    /* GC,GU,G,C,G */+ -1990 -1410  -870 -1410    /* GC,GU,G,C,U */+ -2060 -1230 -1940 -1230    /* GC,GU,G,G,A */+ -2230 -1410  -870 -1410    /* GC,GU,G,G,C */+ -2230  -160 -2120  -160    /* GC,GU,G,G,G */+ -2230 -1410  -870 -1410    /* GC,GU,G,G,U */+ -2230 -1410  -870 -1410    /* GC,GU,G,U,A */+ -1990 -1410  -870 -1410    /* GC,GU,G,U,C */+ -2230 -1410  -870 -1410    /* GC,GU,G,U,G */+ -2230 -1410 -2120 -1410    /* GC,GU,G,U,U */+ -1670 -1890 -1670 -1640    /* GC,GU,U,A,A */+ -1490 -1710 -1490 -1700    /* GC,GU,U,A,C */+ -1510 -1490 -1510 -1710    /* GC,GU,U,A,G */+ -1490 -1710 -1490 -1700    /* GC,GU,U,A,U */+ -1490 -1710 -1490 -1700    /* GC,GU,U,C,A */+ -1490 -1710 -1490 -1700    /* GC,GU,U,C,C */+ -1490 -1710 -1490 -1700    /* GC,GU,U,C,G */+ -1490 -1710 -1490 -1700    /* GC,GU,U,C,U */+ -1320 -1300 -1320 -1520    /* GC,GU,U,G,A */+ -1490 -1710 -1490 -1700    /* GC,GU,U,G,C */+  -240  -460  -240 -1700    /* GC,GU,U,G,G */+ -1490 -1710 -1490 -1700    /* GC,GU,U,G,U */+ -1490 -1710 -1490 -1700    /* GC,GU,U,U,A */+ -1490 -1710 -1490 -1700    /* GC,GU,U,U,C */+ -1490 -1710 -1490 -1700    /* GC,GU,U,U,G */+ -1490 -1710 -1490 -1700    /* GC,GU,U,U,U */+ -2040  -340  -690  -340    /* GC,UG,A,A,A */+  -490  -850 -1200  -850    /* GC,UG,A,A,C */+  -830 -1190 -1540 -1190    /* GC,UG,A,A,G */+  -490  -850 -1200  -850    /* GC,UG,A,A,U */+  -490  -850 -1200  -850    /* GC,UG,A,C,A */+  -490  -850  -960  -850    /* GC,UG,A,C,C */+  -490  -850 -1200  -850    /* GC,UG,A,C,G */+  -490  -850  -960  -850    /* GC,UG,A,C,U */+ -1000 -1360 -1710 -1360    /* GC,UG,A,G,A */+  -490  -850 -1200  -850    /* GC,UG,A,G,C */+   760   400 -1200   400    /* GC,UG,A,G,G */+  -490  -850 -1200  -850    /* GC,UG,A,G,U */+  -490  -850 -1200  -850    /* GC,UG,A,U,A */+  -490  -850  -960  -850    /* GC,UG,A,U,C */+  -490  -850 -1200  -850    /* GC,UG,A,U,G */+  -250  -850 -1200  -850    /* GC,UG,A,U,U */+  -430  -650  -430  -960    /* GC,UG,C,A,A */+  -940 -1160  -940 -1470    /* GC,UG,C,A,C */+ -1280 -1260 -1280 -1570    /* GC,UG,C,A,G */+  -940 -1160  -940 -1470    /* GC,UG,C,A,U */+  -940 -1160  -940 -1470    /* GC,UG,C,C,A */+  -940 -1160  -940 -1470    /* GC,UG,C,C,C */+  -940 -1160  -940 -1470    /* GC,UG,C,C,G */+  -940 -1160  -940 -1470    /* GC,UG,C,C,U */+ -1450 -1430 -1450 -1740    /* GC,UG,C,G,A */+  -940 -1160  -940 -1470    /* GC,UG,C,G,C */+   310    90   310  -220    /* GC,UG,C,G,G */+  -940 -1160  -940 -1470    /* GC,UG,C,G,U */+  -940 -1160  -940 -1470    /* GC,UG,C,U,A */+  -940 -1160  -940 -1470    /* GC,UG,C,U,C */+  -940 -1160  -940 -1470    /* GC,UG,C,U,G */+  -940 -1160  -940 -1470    /* GC,UG,C,U,U */+ -1170  -340   200  -340    /* GC,UG,G,A,A */+ -1680  -850  -310  -850    /* GC,UG,G,A,C */+ -2020 -1190 -1900 -1190    /* GC,UG,G,A,G */+ -1680  -850  -310  -850    /* GC,UG,G,A,U */+ -1680  -850  -310  -850    /* GC,UG,G,C,A */+ -1440  -850  -310  -850    /* GC,UG,G,C,C */+ -1680  -850  -310  -850    /* GC,UG,G,C,G */+ -1440  -850  -310  -850    /* GC,UG,G,C,U */+ -2190 -1360 -2070 -1360    /* GC,UG,G,G,A */+ -1680  -850  -310  -850    /* GC,UG,G,G,C */+ -1680   400 -1560   400    /* GC,UG,G,G,G */+ -1680  -850  -310  -850    /* GC,UG,G,G,U */+ -1680  -850  -310  -850    /* GC,UG,G,U,A */+ -1440  -850  -310  -850    /* GC,UG,G,U,C */+ -1680  -850  -310  -850    /* GC,UG,G,U,G */+ -1680  -850 -1560  -850    /* GC,UG,G,U,U */+  -430  -650  -430  -390    /* GC,UG,U,A,A */+  -940 -1160  -940 -1140    /* GC,UG,U,A,C */+ -1280 -1260 -1280 -1480    /* GC,UG,U,A,G */+  -940 -1160  -940 -1140    /* GC,UG,U,A,U */+  -940 -1160  -940 -1140    /* GC,UG,U,C,A */+  -940 -1160  -940 -1140    /* GC,UG,U,C,C */+  -940 -1160  -940 -1140    /* GC,UG,U,C,G */+  -940 -1160  -940 -1140    /* GC,UG,U,C,U */+ -1450 -1430 -1450 -1650    /* GC,UG,U,G,A */+  -940 -1160  -940 -1140    /* GC,UG,U,G,C */+   310    90   310 -1140    /* GC,UG,U,G,G */+  -940 -1160  -940 -1140    /* GC,UG,U,G,U */+  -940 -1160  -940 -1140    /* GC,UG,U,U,A */+  -940 -1160  -940 -1140    /* GC,UG,U,U,C */+  -940 -1160  -940 -1140    /* GC,UG,U,U,G */+  -940 -1160  -940 -1140    /* GC,UG,U,U,U */+   600   240  -110   240    /* GC,AU,A,A,A */+   290   -70  -420   -70    /* GC,AU,A,A,C */+  -780 -1150 -1500 -1150    /* GC,AU,A,A,G */+   290   -70  -420   -70    /* GC,AU,A,A,U */+   310   -50  -400   -50    /* GC,AU,A,C,A */+   300   -60  -170   -60    /* GC,AU,A,C,C */+   310   -50  -400   -50    /* GC,AU,A,C,G */+   300   -60  -170   -60    /* GC,AU,A,C,U */+  -600  -970 -1320  -970    /* GC,AU,A,G,A */+   290   -70  -420   -70    /* GC,AU,A,G,C */+  1140   770  -830   770    /* GC,AU,A,G,G */+   290   -70  -420   -70    /* GC,AU,A,G,U */+   310   -50  -400   -50    /* GC,AU,A,U,A */+   300   -60  -170   -60    /* GC,AU,A,U,C */+   310   -50  -400   -50    /* GC,AU,A,U,G */+  -430 -1040 -1390 -1040    /* GC,AU,A,U,U */+   150   -60   150  -370    /* GC,AU,C,A,A */+  -150  -370  -150  -680    /* GC,AU,C,A,C */+ -1230 -1210 -1230 -1520    /* GC,AU,C,A,G */+  -150  -370  -150  -680    /* GC,AU,C,A,U */+  -140  -360  -140  -670    /* GC,AU,C,C,A */+  -140  -360  -140  -670    /* GC,AU,C,C,C */+  -140  -360  -140  -670    /* GC,AU,C,C,G */+  -140  -360  -140  -670    /* GC,AU,C,C,U */+ -1050 -1030 -1050 -1340    /* GC,AU,C,G,A */+  -150  -370  -150  -680    /* GC,AU,C,G,C */+   690   470   690   160    /* GC,AU,C,G,G */+  -150  -370  -150  -680    /* GC,AU,C,G,U */+  -140  -360  -140  -670    /* GC,AU,C,U,A */+  -140  -360  -140  -670    /* GC,AU,C,U,C */+  -140  -360  -140  -670    /* GC,AU,C,U,G */+ -1120 -1340 -1120 -1650    /* GC,AU,C,U,U */+  -580   240   780   240    /* GC,AU,G,A,A */+  -890   -70   470   -70    /* GC,AU,G,A,C */+ -1970 -1150 -1860 -1150    /* GC,AU,G,A,G */+  -890   -70   470   -70    /* GC,AU,G,A,U */+  -880   -50   490   -50    /* GC,AU,G,C,A */+  -640   -60   480   -60    /* GC,AU,G,C,C */+  -880   -50   490   -50    /* GC,AU,G,C,G */+  -640   -60   480   -60    /* GC,AU,G,C,U */+ -1790  -970 -1680  -970    /* GC,AU,G,G,A */+  -890   -70   470   -70    /* GC,AU,G,G,C */+ -1300   770 -1190   770    /* GC,AU,G,G,G */+  -890   -70   470   -70    /* GC,AU,G,G,U */+  -880   -50   490   -50    /* GC,AU,G,U,A */+  -640   -60   480   -60    /* GC,AU,G,U,C */+  -880   -50   490   -50    /* GC,AU,G,U,G */+ -1860 -1040 -1750 -1040    /* GC,AU,G,U,U */+   150   -60   150   190    /* GC,AU,U,A,A */+  -150  -370  -150  -360    /* GC,AU,U,A,C */+ -1230 -1210 -1230 -1440    /* GC,AU,U,A,G */+  -150  -370  -150  -360    /* GC,AU,U,A,U */+  -140  -360  -140  -340    /* GC,AU,U,C,A */+  -140  -360  -140  -350    /* GC,AU,U,C,C */+  -140  -360  -140  -340    /* GC,AU,U,C,G */+  -140  -360  -140  -350    /* GC,AU,U,C,U */+ -1050 -1030 -1050 -1260    /* GC,AU,U,G,A */+  -150  -370  -150  -360    /* GC,AU,U,G,C */+   690   470   690  -770    /* GC,AU,U,G,G */+  -150  -370  -150  -360    /* GC,AU,U,G,U */+  -140  -360  -140  -340    /* GC,AU,U,U,A */+  -140  -360  -140  -350    /* GC,AU,U,U,C */+  -140  -360  -140  -340    /* GC,AU,U,U,G */+ -1120 -1340 -1120 -1330    /* GC,AU,U,U,U */+   670   300   -40   300    /* GC,UA,A,A,A */+   390    20  -320    20    /* GC,UA,A,A,C */+  -730 -1100 -1450 -1100    /* GC,UA,A,A,G */+   390    20  -320    20    /* GC,UA,A,A,U */+   540   170  -170   170    /* GC,UA,A,C,A */+   540   170    70   170    /* GC,UA,A,C,C */+   540   170  -170   170    /* GC,UA,A,C,G */+   410    40   -60    40    /* GC,UA,A,C,U */+ -1030 -1400 -1750 -1400    /* GC,UA,A,G,A */+   390    20  -320    20    /* GC,UA,A,G,C */+  1320   960  -640   960    /* GC,UA,A,G,G */+   390    20  -320    20    /* GC,UA,A,G,U */+   540   170  -170   170    /* GC,UA,A,U,A */+   100  -260  -370  -260    /* GC,UA,A,U,C */+   540   170  -170   170    /* GC,UA,A,U,G */+  -160  -760 -1110  -760    /* GC,UA,A,U,U */+   220     0   220  -310    /* GC,UA,C,A,A */+   -60  -280   -60  -590    /* GC,UA,C,A,C */+ -1180 -1160 -1180 -1470    /* GC,UA,C,A,G */+   -60  -280   -60  -590    /* GC,UA,C,A,U */+    90  -130    90  -440    /* GC,UA,C,C,A */+    90  -130    90  -440    /* GC,UA,C,C,C */+    90  -130    90  -440    /* GC,UA,C,C,G */+   -40  -260   -40  -570    /* GC,UA,C,C,U */+ -1480 -1460 -1480 -1770    /* GC,UA,C,G,A */+   -60  -280   -60  -590    /* GC,UA,C,G,C */+   870   650   870   340    /* GC,UA,C,G,G */+   -60  -280   -60  -590    /* GC,UA,C,G,U */+    90  -130    90  -440    /* GC,UA,C,U,A */+  -350  -570  -350  -880    /* GC,UA,C,U,C */+    90  -130    90  -440    /* GC,UA,C,U,G */+  -850 -1070  -850 -1380    /* GC,UA,C,U,U */+  -520   300   850   300    /* GC,UA,G,A,A */+  -800    20   570    20    /* GC,UA,G,A,C */+ -1920 -1100 -1810 -1100    /* GC,UA,G,A,G */+  -800    20   570    20    /* GC,UA,G,A,U */+  -650   170   720   170    /* GC,UA,G,C,A */+  -410   170   720   170    /* GC,UA,G,C,C */+  -650   170   720   170    /* GC,UA,G,C,G */+  -540    40   590    40    /* GC,UA,G,C,U */+ -2220 -1400 -2110 -1400    /* GC,UA,G,G,A */+  -800    20   570    20    /* GC,UA,G,G,C */+ -1120   960 -1000   960    /* GC,UA,G,G,G */+  -800    20   570    20    /* GC,UA,G,G,U */+  -650   170   720   170    /* GC,UA,G,U,A */+  -850  -260   280  -260    /* GC,UA,G,U,C */+  -650   170   720   170    /* GC,UA,G,U,G */+ -1590  -760 -1470  -760    /* GC,UA,G,U,U */+   220     0   220   250    /* GC,UA,U,A,A */+   -60  -280   -60  -260    /* GC,UA,U,A,C */+ -1180 -1160 -1180 -1390    /* GC,UA,U,A,G */+   -60  -280   -60  -260    /* GC,UA,U,A,U */+    90  -130    90  -110    /* GC,UA,U,C,A */+    90  -130    90  -110    /* GC,UA,U,C,C */+    90  -130    90  -110    /* GC,UA,U,C,G */+   -40  -260   -40  -240    /* GC,UA,U,C,U */+ -1480 -1460 -1480 -1690    /* GC,UA,U,G,A */+   -60  -280   -60  -260    /* GC,UA,U,G,C */+   870   650   870  -580    /* GC,UA,U,G,G */+   -60  -280   -60  -260    /* GC,UA,U,G,U */+    90  -130    90  -110    /* GC,UA,U,U,A */+  -350  -570  -350  -550    /* GC,UA,U,U,C */+    90  -130    90  -110    /* GC,UA,U,U,G */+  -850 -1070  -850 -1050    /* GC,UA,U,U,U */+ -1370 -1210 -1030 -1210    /* GU,CG,A,A,A */+ -1700 -1520 -1340 -1520    /* GU,CG,A,A,C */+ -1600 -1420 -1250 -1420    /* GU,CG,A,A,G */+ -1700 -1520 -1340 -1520    /* GU,CG,A,A,U */+ -1240 -1060  -890 -1060    /* GU,CG,A,C,A */+ -1250 -1070  -650 -1070    /* GU,CG,A,C,C */+ -1240 -1060  -890 -1060    /* GU,CG,A,C,G */+ -1300 -1120  -700 -1120    /* GU,CG,A,C,U */+ -1890 -1710 -1530 -1710    /* GU,CG,A,G,A */+ -1700 -1520 -1340 -1520    /* GU,CG,A,G,C */+ -1050  -870 -1940  -870    /* GU,CG,A,G,G */+ -1700 -1520 -1340 -1520    /* GU,CG,A,G,U */+ -1240 -1060  -890 -1060    /* GU,CG,A,U,A */+ -1190 -1010  -590 -1010    /* GU,CG,A,U,C */+ -1240 -1060  -890 -1060    /* GU,CG,A,U,G */+ -1790 -1850 -1680 -1850    /* GU,CG,A,U,U */+ -1210 -1210 -1210 -1210    /* GU,CG,C,A,A */+ -1520 -1520 -1520 -1520    /* GU,CG,C,A,C */+ -1420 -1180 -1420 -1180    /* GU,CG,C,A,G */+ -1520 -1520 -1520 -1520    /* GU,CG,C,A,U */+ -1060 -1060 -1060 -1060    /* GU,CG,C,C,A */+ -1070 -1070 -1070 -1070    /* GU,CG,C,C,C */+ -1060 -1060 -1060 -1060    /* GU,CG,C,C,G */+ -1120 -1120 -1120 -1120    /* GU,CG,C,C,U */+ -1710 -1470 -1710 -1470    /* GU,CG,C,G,A */+ -1520 -1520 -1520 -1520    /* GU,CG,C,G,C */+  -870  -870  -870  -870    /* GU,CG,C,G,G */+ -1520 -1520 -1520 -1520    /* GU,CG,C,G,U */+ -1060 -1060 -1060 -1060    /* GU,CG,C,U,A */+ -1010 -1010 -1010 -1010    /* GU,CG,C,U,C */+ -1060 -1060 -1060 -1060    /* GU,CG,C,U,G */+ -1850 -1850 -1850 -1850    /* GU,CG,C,U,U */+ -1220 -1210    40 -1210    /* GU,CG,G,A,A */+ -1530 -1520  -270 -1520    /* GU,CG,G,A,C */+ -1440 -1420 -1420 -1420    /* GU,CG,G,A,G */+ -1530 -1520  -270 -1520    /* GU,CG,G,A,U */+ -1080 -1060   190 -1060    /* GU,CG,G,C,A */+  -840 -1070   180 -1070    /* GU,CG,G,C,C */+ -1080 -1060   190 -1060    /* GU,CG,G,C,G */+  -890 -1120   130 -1120    /* GU,CG,G,C,U */+ -1720 -1710 -1710 -1710    /* GU,CG,G,G,A */+ -1530 -1520  -270 -1520    /* GU,CG,G,G,C */+ -2130  -870 -2120  -870    /* GU,CG,G,G,G */+ -1530 -1520  -270 -1520    /* GU,CG,G,G,U */+ -1080 -1060   190 -1060    /* GU,CG,G,U,A */+  -780 -1010   240 -1010    /* GU,CG,G,U,C */+ -1080 -1060   190 -1060    /* GU,CG,G,U,G */+ -1870 -1850 -1850 -1850    /* GU,CG,G,U,U */+ -1210 -1210 -1210  -970    /* GU,CG,U,A,A */+ -1520 -1520 -1520 -1520    /* GU,CG,U,A,C */+ -1420 -1180 -1420 -1420    /* GU,CG,U,A,G */+ -1520 -1520 -1520 -1520    /* GU,CG,U,A,U */+ -1060 -1060 -1060 -1060    /* GU,CG,U,C,A */+ -1070 -1070 -1070 -1070    /* GU,CG,U,C,C */+ -1060 -1060 -1060 -1060    /* GU,CG,U,C,G */+ -1120 -1120 -1120 -1120    /* GU,CG,U,C,U */+ -1710 -1470 -1710 -1710    /* GU,CG,U,G,A */+ -1520 -1520 -1520 -1520    /* GU,CG,U,G,C */+  -870  -870  -870 -2120    /* GU,CG,U,G,G */+ -1520 -1520 -1520 -1520    /* GU,CG,U,G,U */+ -1060 -1060 -1060 -1060    /* GU,CG,U,U,A */+ -1010 -1010 -1010 -1010    /* GU,CG,U,U,C */+ -1060 -1060 -1060 -1060    /* GU,CG,U,U,G */+ -1850 -1850 -1850 -1850    /* GU,CG,U,U,U */+ -1220 -1040  -870 -1040    /* GU,GC,A,A,A */+ -1670 -1490 -1320 -1490    /* GU,GC,A,A,C */+ -2410 -2230 -2060 -2230    /* GU,GC,A,A,G */+ -1670 -1490 -1320 -1490    /* GU,GC,A,A,U */+ -1590 -1410 -1230 -1410    /* GU,GC,A,C,A */+ -1890 -1710 -1300 -1710    /* GU,GC,A,C,C */+ -1590 -1410 -1230 -1410    /* GU,GC,A,C,G */+ -1890 -1710 -1300 -1710    /* GU,GC,A,C,U */+ -1940 -1760 -1580 -1760    /* GU,GC,A,G,A */+ -1670 -1490 -1320 -1490    /* GU,GC,A,G,C */+ -1050  -870 -1940  -870    /* GU,GC,A,G,G */+ -1670 -1490 -1320 -1490    /* GU,GC,A,G,U */+ -1590 -1410 -1230 -1410    /* GU,GC,A,U,A */+ -2200 -2020 -1610 -2020    /* GU,GC,A,U,C */+ -1590 -1410 -1230 -1410    /* GU,GC,A,U,G */+ -1640 -1700 -1520 -1700    /* GU,GC,A,U,U */+ -1040 -1040 -1040 -1040    /* GU,GC,C,A,A */+ -1490 -1490 -1490 -1490    /* GU,GC,C,A,C */+ -2230 -1990 -2230 -1990    /* GU,GC,C,A,G */+ -1490 -1490 -1490 -1490    /* GU,GC,C,A,U */+ -1410 -1410 -1410 -1410    /* GU,GC,C,C,A */+ -1710 -1710 -1710 -1710    /* GU,GC,C,C,C */+ -1410 -1410 -1410 -1410    /* GU,GC,C,C,G */+ -1710 -1710 -1710 -1710    /* GU,GC,C,C,U */+ -1760 -1520 -1760 -1520    /* GU,GC,C,G,A */+ -1490 -1490 -1490 -1490    /* GU,GC,C,G,C */+  -870  -870  -870  -870    /* GU,GC,C,G,G */+ -1490 -1490 -1490 -1490    /* GU,GC,C,G,U */+ -1410 -1410 -1410 -1410    /* GU,GC,C,U,A */+ -2020 -2020 -2020 -2020    /* GU,GC,C,U,C */+ -1410 -1410 -1410 -1410    /* GU,GC,C,U,G */+ -1700 -1700 -1700 -1700    /* GU,GC,C,U,U */+ -1060 -1040   210 -1040    /* GU,GC,G,A,A */+ -1510 -1490  -240 -1490    /* GU,GC,G,A,C */+ -2250 -2230 -2230 -2230    /* GU,GC,G,A,G */+ -1510 -1490  -240 -1490    /* GU,GC,G,A,U */+ -1420 -1410  -160 -1410    /* GU,GC,G,C,A */+ -1490 -1710  -460 -1710    /* GU,GC,G,C,C */+ -1420 -1410  -160 -1410    /* GU,GC,G,C,G */+ -1490 -1710  -460 -1710    /* GU,GC,G,C,U */+ -1770 -1760 -1760 -1760    /* GU,GC,G,G,A */+ -1510 -1490  -240 -1490    /* GU,GC,G,G,C */+ -2130  -870 -2120  -870    /* GU,GC,G,G,G */+ -1510 -1490  -240 -1490    /* GU,GC,G,G,U */+ -1420 -1410  -160 -1410    /* GU,GC,G,U,A */+ -1800 -2020  -770 -2020    /* GU,GC,G,U,C */+ -1420 -1410  -160 -1410    /* GU,GC,G,U,G */+ -1710 -1700 -1700 -1700    /* GU,GC,G,U,U */+ -1040 -1040 -1040  -800    /* GU,GC,U,A,A */+ -1490 -1490 -1490 -1490    /* GU,GC,U,A,C */+ -2230 -1990 -2230 -2230    /* GU,GC,U,A,G */+ -1490 -1490 -1490 -1490    /* GU,GC,U,A,U */+ -1410 -1410 -1410 -1410    /* GU,GC,U,C,A */+ -1710 -1710 -1710 -1710    /* GU,GC,U,C,C */+ -1410 -1410 -1410 -1410    /* GU,GC,U,C,G */+ -1710 -1710 -1710 -1710    /* GU,GC,U,C,U */+ -1760 -1520 -1760 -1760    /* GU,GC,U,G,A */+ -1490 -1490 -1490 -1490    /* GU,GC,U,G,C */+  -870  -870  -870 -2120    /* GU,GC,U,G,G */+ -1490 -1490 -1490 -1490    /* GU,GC,U,G,U */+ -1410 -1410 -1410 -1410    /* GU,GC,U,U,A */+ -2020 -2020 -2020 -2020    /* GU,GC,U,U,C */+ -1410 -1410 -1410 -1410    /* GU,GC,U,U,G */+ -1700 -1700 -1700 -1700    /* GU,GC,U,U,U */+ -2320 -2140 -1960 -2140    /* GU,GU,A,A,A */+ -2140 -1960 -1780 -1960    /* GU,GU,A,A,C */+ -2150 -1970 -1800 -1970    /* GU,GU,A,A,G */+ -2140 -1960 -1780 -1960    /* GU,GU,A,A,U */+ -2140 -1960 -1780 -1960    /* GU,GU,A,C,A */+ -2140 -1960 -1540 -1960    /* GU,GU,A,C,C */+ -2140 -1960 -1780 -1960    /* GU,GU,A,C,G */+ -2140 -1960 -1540 -1960    /* GU,GU,A,C,U */+ -1960 -1780 -1610 -1780    /* GU,GU,A,G,A */+ -2140 -1960 -1780 -1960    /* GU,GU,A,G,C */+  -890  -710 -1780  -710    /* GU,GU,A,G,G */+ -2140 -1960 -1780 -1960    /* GU,GU,A,G,U */+ -2140 -1960 -1780 -1960    /* GU,GU,A,U,A */+ -2140 -1960 -1540 -1960    /* GU,GU,A,U,C */+ -2140 -1960 -1780 -1960    /* GU,GU,A,U,G */+ -1900 -1960 -1780 -1960    /* GU,GU,A,U,U */+ -2140 -2140 -2140 -2140    /* GU,GU,C,A,A */+ -1960 -1960 -1960 -1960    /* GU,GU,C,A,C */+ -1970 -1730 -1970 -1730    /* GU,GU,C,A,G */+ -1960 -1960 -1960 -1960    /* GU,GU,C,A,U */+ -1960 -1960 -1960 -1960    /* GU,GU,C,C,A */+ -1960 -1960 -1960 -1960    /* GU,GU,C,C,C */+ -1960 -1960 -1960 -1960    /* GU,GU,C,C,G */+ -1960 -1960 -1960 -1960    /* GU,GU,C,C,U */+ -1780 -1540 -1780 -1540    /* GU,GU,C,G,A */+ -1960 -1960 -1960 -1960    /* GU,GU,C,G,C */+  -710  -710  -710  -710    /* GU,GU,C,G,G */+ -1960 -1960 -1960 -1960    /* GU,GU,C,G,U */+ -1960 -1960 -1960 -1960    /* GU,GU,C,U,A */+ -1960 -1960 -1960 -1960    /* GU,GU,C,U,C */+ -1960 -1960 -1960 -1960    /* GU,GU,C,U,G */+ -1960 -1960 -1960 -1960    /* GU,GU,C,U,U */+ -2150 -2140  -890 -2140    /* GU,GU,G,A,A */+ -1970 -1960  -710 -1960    /* GU,GU,G,A,C */+ -1990 -1970 -1970 -1970    /* GU,GU,G,A,G */+ -1970 -1960  -710 -1960    /* GU,GU,G,A,U */+ -1970 -1960  -710 -1960    /* GU,GU,G,C,A */+ -1730 -1960  -710 -1960    /* GU,GU,G,C,C */+ -1970 -1960  -710 -1960    /* GU,GU,G,C,G */+ -1730 -1960  -710 -1960    /* GU,GU,G,C,U */+ -1800 -1780 -1780 -1780    /* GU,GU,G,G,A */+ -1970 -1960  -710 -1960    /* GU,GU,G,G,C */+ -1970  -710 -1960  -710    /* GU,GU,G,G,G */+ -1970 -1960  -710 -1960    /* GU,GU,G,G,U */+ -1970 -1960  -710 -1960    /* GU,GU,G,U,A */+ -1730 -1960  -710 -1960    /* GU,GU,G,U,C */+ -1970 -1960  -710 -1960    /* GU,GU,G,U,G */+ -1970 -1960 -1960 -1960    /* GU,GU,G,U,U */+ -2140 -2140 -2140 -1900    /* GU,GU,U,A,A */+ -1960 -1960 -1960 -1960    /* GU,GU,U,A,C */+ -1970 -1730 -1970 -1970    /* GU,GU,U,A,G */+ -1960 -1960 -1960 -1960    /* GU,GU,U,A,U */+ -1960 -1960 -1960 -1960    /* GU,GU,U,C,A */+ -1960 -1960 -1960 -1960    /* GU,GU,U,C,C */+ -1960 -1960 -1960 -1960    /* GU,GU,U,C,G */+ -1960 -1960 -1960 -1960    /* GU,GU,U,C,U */+ -1780 -1540 -1780 -1780    /* GU,GU,U,G,A */+ -1960 -1960 -1960 -1960    /* GU,GU,U,G,C */+  -710  -710  -710 -1960    /* GU,GU,U,G,G */+ -1960 -1960 -1960 -1960    /* GU,GU,U,G,U */+ -1960 -1960 -1960 -1960    /* GU,GU,U,U,A */+ -1960 -1960 -1960 -1960    /* GU,GU,U,U,C */+ -1960 -1960 -1960 -1960    /* GU,GU,U,U,G */+ -1960 -1960 -1960 -1960    /* GU,GU,U,U,U */+   -70  -890   -30  -890    /* GU,UG,A,A,A */+ -1580 -1400 -1230 -1400    /* GU,UG,A,A,C */+ -1600 -1740 -1570 -1740    /* GU,UG,A,A,G */+ -1580 -1400 -1230 -1400    /* GU,UG,A,A,U */+ -1580 -1400 -1230 -1400    /* GU,UG,A,C,A */+ -1580 -1400  -990 -1400    /* GU,UG,A,C,C */+ -1580 -1400 -1230 -1400    /* GU,UG,A,C,G */+ -1580 -1400  -990 -1400    /* GU,UG,A,C,U */+ -2090 -1910 -1740 -1910    /* GU,UG,A,G,A */+ -1580 -1400 -1230 -1400    /* GU,UG,A,G,C */+  -330  -150 -1230  -150    /* GU,UG,A,G,G */+ -1580 -1400 -1230 -1400    /* GU,UG,A,G,U */+ -1580 -1400 -1230 -1400    /* GU,UG,A,U,A */+ -1580 -1400  -990 -1400    /* GU,UG,A,U,C */+ -1580 -1400 -1230 -1400    /* GU,UG,A,U,G */+ -1340 -1400 -1230 -1400    /* GU,UG,A,U,U */+  -890  -890  -890  -890    /* GU,UG,C,A,A */+ -1400 -1400 -1400 -1400    /* GU,UG,C,A,C */+ -1740 -1500 -1740 -1500    /* GU,UG,C,A,G */+ -1400 -1400 -1400 -1400    /* GU,UG,C,A,U */+ -1400 -1400 -1400 -1400    /* GU,UG,C,C,A */+ -1400 -1400 -1400 -1400    /* GU,UG,C,C,C */+ -1400 -1400 -1400 -1400    /* GU,UG,C,C,G */+ -1400 -1400 -1400 -1400    /* GU,UG,C,C,U */+ -1910 -1670 -1910 -1670    /* GU,UG,C,G,A */+ -1400 -1400 -1400 -1400    /* GU,UG,C,G,C */+  -150  -150  -150  -150    /* GU,UG,C,G,G */+ -1400 -1400 -1400 -1400    /* GU,UG,C,G,U */+ -1400 -1400 -1400 -1400    /* GU,UG,C,U,A */+ -1400 -1400 -1400 -1400    /* GU,UG,C,U,C */+ -1400 -1400 -1400 -1400    /* GU,UG,C,U,G */+ -1400 -1400 -1400 -1400    /* GU,UG,C,U,U */+  -910  -890   360  -890    /* GU,UG,G,A,A */+ -1420 -1400  -150 -1400    /* GU,UG,G,A,C */+ -3040 -1740 -1740 -1740    /* GU,UG,G,A,G */+ -1420 -1400  -150 -1400    /* GU,UG,G,A,U */+ -1420 -1400  -150 -1400    /* GU,UG,G,C,A */+ -1180 -1400  -150 -1400    /* GU,UG,G,C,C */+ -1420 -1400  -150 -1400    /* GU,UG,G,C,G */+ -1180 -1400  -150 -1400    /* GU,UG,G,C,U */+ -1930 -1910 -1910 -1910    /* GU,UG,G,G,A */+ -1420 -1400  -150 -1400    /* GU,UG,G,G,C */+ -1420  -150 -1400  -150    /* GU,UG,G,G,G */+ -1420 -1400  -150 -1400    /* GU,UG,G,G,U */+ -1420 -1400  -150 -1400    /* GU,UG,G,U,A */+ -1180 -1400  -150 -1400    /* GU,UG,G,U,C */+ -1420 -1400  -150 -1400    /* GU,UG,G,U,G */+ -1420 -1400 -1400 -1400    /* GU,UG,G,U,U */+  -890  -890  -890  -650    /* GU,UG,U,A,A */+ -1400 -1400 -1400 -1400    /* GU,UG,U,A,C */+ -1740 -1500 -1740 -1740    /* GU,UG,U,A,G */+ -1400 -1400 -1400 -1400    /* GU,UG,U,A,U */+ -1400 -1400 -1400 -1400    /* GU,UG,U,C,A */+ -1400 -1400 -1400 -1400    /* GU,UG,U,C,C */+ -1400 -1400 -1400 -1400    /* GU,UG,U,C,G */+ -1400 -1400 -1400 -1400    /* GU,UG,U,C,U */+ -1910 -1670 -1910 -1910    /* GU,UG,U,G,A */+ -1400 -1400 -1400 -1400    /* GU,UG,U,G,C */+  -150  -150  -150 -1400    /* GU,UG,U,G,G */+ -1400 -1400 -1400 -1400    /* GU,UG,U,G,U */+ -1400 -1400 -1400 -1400    /* GU,UG,U,U,A */+ -1400 -1400 -1400 -1400    /* GU,UG,U,U,C */+ -1400 -1400 -1400 -1400    /* GU,UG,U,U,G */+ -1400 -1400 -1400 -1400    /* GU,UG,U,U,U */+  -490  -310  -130  -310    /* GU,AU,A,A,A */+  -800  -620  -440  -620    /* GU,AU,A,A,C */+ -1880 -1700 -1520 -1700    /* GU,AU,A,A,G */+  -800  -620  -440  -620    /* GU,AU,A,A,U */+  -780  -600  -430  -600    /* GU,AU,A,C,A */+  -790  -610  -190  -610    /* GU,AU,A,C,C */+  -780  -600  -430  -600    /* GU,AU,A,C,G */+  -790  -610  -190  -610    /* GU,AU,A,C,U */+ -1700 -1520 -1340 -1520    /* GU,AU,A,G,A */+  -800  -620  -440  -620    /* GU,AU,A,G,C */+    40   220  -850   220    /* GU,AU,A,G,G */+  -800  -620  -440  -620    /* GU,AU,A,G,U */+  -780  -600  -430  -600    /* GU,AU,A,U,A */+  -790  -610  -190  -610    /* GU,AU,A,U,C */+  -780  -600  -430  -600    /* GU,AU,A,U,G */+ -1530 -1590 -1410 -1590    /* GU,AU,A,U,U */+  -310  -310  -310  -310    /* GU,AU,C,A,A */+  -620  -620  -620  -620    /* GU,AU,C,A,C */+ -1700 -1460 -1700 -1460    /* GU,AU,C,A,G */+  -620  -620  -620  -620    /* GU,AU,C,A,U */+  -600  -600  -600  -600    /* GU,AU,C,C,A */+  -610  -610  -610  -610    /* GU,AU,C,C,C */+  -600  -600  -600  -600    /* GU,AU,C,C,G */+  -610  -610  -610  -610    /* GU,AU,C,C,U */+ -1520 -1280 -1520 -1280    /* GU,AU,C,G,A */+  -620  -620  -620  -620    /* GU,AU,C,G,C */+   220   220   220   220    /* GU,AU,C,G,G */+  -620  -620  -620  -620    /* GU,AU,C,G,U */+  -600  -600  -600  -600    /* GU,AU,C,U,A */+  -610  -610  -610  -610    /* GU,AU,C,U,C */+  -600  -600  -600  -600    /* GU,AU,C,U,G */+ -1590 -1590 -1590 -1590    /* GU,AU,C,U,U */+  -320  -310   940  -310    /* GU,AU,G,A,A */+  -630  -620   630  -620    /* GU,AU,G,A,C */+ -1710 -1700 -1700 -1700    /* GU,AU,G,A,G */+  -630  -620   630  -620    /* GU,AU,G,A,U */+  -620  -600   650  -600    /* GU,AU,G,C,A */+  -380  -610   640  -610    /* GU,AU,G,C,C */+  -620  -600   650  -600    /* GU,AU,G,C,G */+  -380  -610   640  -610    /* GU,AU,G,C,U */+ -1530 -1520 -1520 -1520    /* GU,AU,G,G,A */+  -630  -620   630  -620    /* GU,AU,G,G,C */+ -1040   220 -1030   220    /* GU,AU,G,G,G */+  -630  -620   630  -620    /* GU,AU,G,G,U */+  -620  -600   650  -600    /* GU,AU,G,U,A */+  -380  -610   640  -610    /* GU,AU,G,U,C */+  -620  -600   650  -600    /* GU,AU,G,U,G */+ -1600 -1590 -1590 -1590    /* GU,AU,G,U,U */+  -310  -310  -310   -70    /* GU,AU,U,A,A */+  -620  -620  -620  -620    /* GU,AU,U,A,C */+ -1700 -1460 -1700 -1700    /* GU,AU,U,A,G */+  -620  -620  -620  -620    /* GU,AU,U,A,U */+  -600  -600  -600  -600    /* GU,AU,U,C,A */+  -610  -610  -610  -610    /* GU,AU,U,C,C */+  -600  -600  -600  -600    /* GU,AU,U,C,G */+  -610  -610  -610  -610    /* GU,AU,U,C,U */+ -1520 -1280 -1520 -1520    /* GU,AU,U,G,A */+  -620  -620  -620  -620    /* GU,AU,U,G,C */+   220   220   220 -1030    /* GU,AU,U,G,G */+  -620  -620  -620  -620    /* GU,AU,U,G,U */+  -600  -600  -600  -600    /* GU,AU,U,U,A */+  -610  -610  -610  -610    /* GU,AU,U,U,C */+  -600  -600  -600  -600    /* GU,AU,U,U,G */+ -1590 -1590 -1590 -1590    /* GU,AU,U,U,U */+  -420  -240   -70  -240    /* GU,UA,A,A,A */+  -700  -520  -350  -520    /* GU,UA,A,A,C */+ -1830 -1650 -1470 -1650    /* GU,UA,A,A,G */+  -700  -520  -350  -520    /* GU,UA,A,A,U */+  -550  -370  -200  -370    /* GU,UA,A,C,A */+  -550  -370    40  -370    /* GU,UA,A,C,C */+  -550  -370  -200  -370    /* GU,UA,A,C,G */+  -680  -500   -90  -500    /* GU,UA,A,C,U */+ -2130 -1950 -1770 -1950    /* GU,UA,A,G,A */+  -700  -520  -350  -520    /* GU,UA,A,G,C */+   230   410  -670   410    /* GU,UA,A,G,G */+  -700  -520  -350  -520    /* GU,UA,A,G,U */+  -550  -370  -200  -370    /* GU,UA,A,U,A */+  -990  -810  -400  -810    /* GU,UA,A,U,C */+  -550  -370  -200  -370    /* GU,UA,A,U,G */+ -1250 -1310 -1140 -1310    /* GU,UA,A,U,U */+  -240  -240  -240  -240    /* GU,UA,C,A,A */+  -520  -520  -520  -520    /* GU,UA,C,A,C */+ -1650 -1410 -1650 -1410    /* GU,UA,C,A,G */+  -520  -520  -520  -520    /* GU,UA,C,A,U */+  -370  -370  -370  -370    /* GU,UA,C,C,A */+  -370  -370  -370  -370    /* GU,UA,C,C,C */+  -370  -370  -370  -370    /* GU,UA,C,C,G */+  -500  -500  -500  -500    /* GU,UA,C,C,U */+ -1950 -1710 -1950 -1710    /* GU,UA,C,G,A */+  -520  -520  -520  -520    /* GU,UA,C,G,C */+   410   410   410   410    /* GU,UA,C,G,G */+  -520  -520  -520  -520    /* GU,UA,C,G,U */+  -370  -370  -370  -370    /* GU,UA,C,U,A */+  -810  -810  -810  -810    /* GU,UA,C,U,C */+  -370  -370  -370  -370    /* GU,UA,C,U,G */+ -1310 -1310 -1310 -1310    /* GU,UA,C,U,U */+  -260  -240  1010  -240    /* GU,UA,G,A,A */+  -540  -520   730  -520    /* GU,UA,G,A,C */+ -1660 -1650 -1650 -1650    /* GU,UA,G,A,G */+  -540  -520   730  -520    /* GU,UA,G,A,U */+  -390  -370   880  -370    /* GU,UA,G,C,A */+  -150  -370   880  -370    /* GU,UA,G,C,C */+  -390  -370   880  -370    /* GU,UA,G,C,G */+  -280  -500   750  -500    /* GU,UA,G,C,U */+ -1960 -1950 -1950 -1950    /* GU,UA,G,G,A */+  -540  -520   730  -520    /* GU,UA,G,G,C */+  -860   410  -840   410    /* GU,UA,G,G,G */+  -540  -520   730  -520    /* GU,UA,G,G,U */+  -390  -370   880  -370    /* GU,UA,G,U,A */+  -590  -810   440  -810    /* GU,UA,G,U,C */+  -390  -370   880  -370    /* GU,UA,G,U,G */+ -1330 -1310 -1310 -1310    /* GU,UA,G,U,U */+  -240  -240  -240     0    /* GU,UA,U,A,A */+  -520  -520  -520  -520    /* GU,UA,U,A,C */+ -1650 -1410 -1650 -1650    /* GU,UA,U,A,G */+  -520  -520  -520  -520    /* GU,UA,U,A,U */+  -370  -370  -370  -370    /* GU,UA,U,C,A */+  -370  -370  -370  -370    /* GU,UA,U,C,C */+  -370  -370  -370  -370    /* GU,UA,U,C,G */+  -500  -500  -500  -500    /* GU,UA,U,C,U */+ -1950 -1710 -1950 -1950    /* GU,UA,U,G,A */+  -520  -520  -520  -520    /* GU,UA,U,G,C */+   410   410   410  -840    /* GU,UA,U,G,G */+  -520  -520  -520  -520    /* GU,UA,U,G,U */+  -370  -370  -370  -370    /* GU,UA,U,U,A */+  -810  -810  -810  -810    /* GU,UA,U,U,C */+  -370  -370  -370  -370    /* GU,UA,U,U,G */+ -1310 -1310 -1310 -1310    /* GU,UA,U,U,U */+  -140  -650 -1160  -650    /* UG,CG,A,A,A */+  -450  -960 -1470  -960    /* UG,CG,A,A,C */+  -360  -870 -1380  -870    /* UG,CG,A,A,G */+  -450  -960 -1470  -960    /* UG,CG,A,A,U */+     0  -510 -1020  -510    /* UG,CG,A,C,A */+     0  -510  -780  -510    /* UG,CG,A,C,C */+     0  -510 -1020  -510    /* UG,CG,A,C,G */+   -50  -560  -830  -560    /* UG,CG,A,C,U */+  -640 -1150 -1660 -1150    /* UG,CG,A,G,A */+  -450  -960 -1470  -960    /* UG,CG,A,G,C */+   200  -310 -2070  -310    /* UG,CG,A,G,G */+  -450  -960 -1470  -960    /* UG,CG,A,G,U */+     0  -510 -1020  -510    /* UG,CG,A,U,A */+    50  -450  -720  -450    /* UG,CG,A,U,C */+     0  -510 -1020  -510    /* UG,CG,A,U,G */+  -550 -1300 -1810 -1300    /* UG,CG,A,U,U */+  -650  -650  -650  -650    /* UG,CG,C,A,A */+  -960  -960  -960  -960    /* UG,CG,C,A,C */+  -870  -630  -870  -630    /* UG,CG,C,A,G */+  -960  -960  -960  -960    /* UG,CG,C,A,U */+  -510  -510  -510  -510    /* UG,CG,C,C,A */+  -510  -510  -510  -510    /* UG,CG,C,C,C */+  -510  -510  -510  -510    /* UG,CG,C,C,G */+  -560  -560  -560  -560    /* UG,CG,C,C,U */+ -1150  -910 -1150  -910    /* UG,CG,C,G,A */+  -960  -960  -960  -960    /* UG,CG,C,G,C */+  -310  -310  -310  -310    /* UG,CG,C,G,G */+  -960  -960  -960  -960    /* UG,CG,C,G,U */+  -510  -510  -510  -510    /* UG,CG,C,U,A */+  -450  -450  -450  -450    /* UG,CG,C,U,C */+  -510  -510  -510  -510    /* UG,CG,C,U,G */+ -1300 -1300 -1300 -1300    /* UG,CG,C,U,U */+  -990  -650   600  -650    /* UG,CG,G,A,A */+ -1300  -960   290  -960    /* UG,CG,G,A,C */+ -1210  -870  -870  -870    /* UG,CG,G,A,G */+ -1300  -960   290  -960    /* UG,CG,G,A,U */+  -850  -510   740  -510    /* UG,CG,G,C,A */+  -610  -510   740  -510    /* UG,CG,G,C,C */+  -850  -510   740  -510    /* UG,CG,G,C,G */+  -660  -560   690  -560    /* UG,CG,G,C,U */+ -1490 -1150 -1150 -1150    /* UG,CG,G,G,A */+ -1300  -960   290  -960    /* UG,CG,G,G,C */+ -1900  -310 -1560  -310    /* UG,CG,G,G,G */+ -1300  -960   290  -960    /* UG,CG,G,G,U */+  -850  -510   740  -510    /* UG,CG,G,U,A */+  -550  -450   800  -450    /* UG,CG,G,U,C */+  -850  -510   740  -510    /* UG,CG,G,U,G */+ -1640 -1300 -1300 -1300    /* UG,CG,G,U,U */+  -650  -650  -650  -410    /* UG,CG,U,A,A */+  -960  -960  -960  -960    /* UG,CG,U,A,C */+  -870  -630  -870  -870    /* UG,CG,U,A,G */+  -960  -960  -960  -960    /* UG,CG,U,A,U */+  -510  -510  -510  -510    /* UG,CG,U,C,A */+  -510  -510  -510  -510    /* UG,CG,U,C,C */+  -510  -510  -510  -510    /* UG,CG,U,C,G */+  -560  -560  -560  -560    /* UG,CG,U,C,U */+ -1150  -910 -1150 -1150    /* UG,CG,U,G,A */+  -960  -960  -960  -960    /* UG,CG,U,G,C */+  -310  -310  -310 -1560    /* UG,CG,U,G,G */+  -960  -960  -960  -960    /* UG,CG,U,G,U */+  -510  -510  -510  -510    /* UG,CG,U,U,A */+  -450  -450  -450  -450    /* UG,CG,U,U,C */+  -510  -510  -510  -510    /* UG,CG,U,U,G */+ -1300 -1300 -1300 -1300    /* UG,CG,U,U,U */+ -2040  -490 -1000  -490    /* UG,GC,A,A,A */+  -430  -940 -1450  -940    /* UG,GC,A,A,C */+ -1170 -1680 -2190 -1680    /* UG,GC,A,A,G */+  -430  -940 -1450  -940    /* UG,GC,A,A,U */+  -340  -850 -1360  -850    /* UG,GC,A,C,A */+  -650 -1160 -1430 -1160    /* UG,GC,A,C,C */+  -340  -850 -1360  -850    /* UG,GC,A,C,G */+  -650 -1160 -1430 -1160    /* UG,GC,A,C,U */+  -690 -1200 -1710 -1200    /* UG,GC,A,G,A */+  -430  -940 -1450  -940    /* UG,GC,A,G,C */+   200  -310 -2070  -310    /* UG,GC,A,G,G */+  -430  -940 -1450  -940    /* UG,GC,A,G,U */+  -340  -850 -1360  -850    /* UG,GC,A,U,A */+  -960 -1470 -1740 -1470    /* UG,GC,A,U,C */+  -340  -850 -1360  -850    /* UG,GC,A,U,G */+  -390 -1140 -1650 -1140    /* UG,GC,A,U,U */+  -490  -490  -490  -490    /* UG,GC,C,A,A */+  -940  -940  -940  -940    /* UG,GC,C,A,C */+ -1680 -1440 -1680 -1440    /* UG,GC,C,A,G */+  -940  -940  -940  -940    /* UG,GC,C,A,U */+  -850  -850  -850  -850    /* UG,GC,C,C,A */+ -1160 -1160 -1160 -1160    /* UG,GC,C,C,C */+  -850  -850  -850  -850    /* UG,GC,C,C,G */+ -1160 -1160 -1160 -1160    /* UG,GC,C,C,U */+ -1200  -960 -1200  -960    /* UG,GC,C,G,A */+  -940  -940  -940  -940    /* UG,GC,C,G,C */+  -310  -310  -310  -310    /* UG,GC,C,G,G */+  -940  -940  -940  -940    /* UG,GC,C,G,U */+  -850  -850  -850  -850    /* UG,GC,C,U,A */+ -1470 -1470 -1470 -1470    /* UG,GC,C,U,C */+  -850  -850  -850  -850    /* UG,GC,C,U,G */+ -1140 -1140 -1140 -1140    /* UG,GC,C,U,U */+  -830  -490   760  -490    /* UG,GC,G,A,A */+ -1280  -940   310  -940    /* UG,GC,G,A,C */+ -2020 -1680 -1680 -1680    /* UG,GC,G,A,G */+ -1280  -940   310  -940    /* UG,GC,G,A,U */+ -1190  -850   400  -850    /* UG,GC,G,C,A */+ -1260 -1160    90 -1160    /* UG,GC,G,C,C */+ -1190  -850   400  -850    /* UG,GC,G,C,G */+ -1260 -1160    90 -1160    /* UG,GC,G,C,U */+ -1540 -1200 -1200 -1200    /* UG,GC,G,G,A */+ -1280  -940   310  -940    /* UG,GC,G,G,C */+ -1900  -310 -1560  -310    /* UG,GC,G,G,G */+ -1280  -940   310  -940    /* UG,GC,G,G,U */+ -1190  -850   400  -850    /* UG,GC,G,U,A */+ -1570 -1470  -220 -1470    /* UG,GC,G,U,C */+ -1190  -850   400  -850    /* UG,GC,G,U,G */+ -1480 -1140 -1140 -1140    /* UG,GC,G,U,U */+  -490  -490  -490  -250    /* UG,GC,U,A,A */+  -940  -940  -940  -940    /* UG,GC,U,A,C */+ -1680 -1440 -1680 -1680    /* UG,GC,U,A,G */+  -940  -940  -940  -940    /* UG,GC,U,A,U */+  -850  -850  -850  -850    /* UG,GC,U,C,A */+ -1160 -1160 -1160 -1160    /* UG,GC,U,C,C */+  -850  -850  -850  -850    /* UG,GC,U,C,G */+ -1160 -1160 -1160 -1160    /* UG,GC,U,C,U */+ -1200  -960 -1200 -1200    /* UG,GC,U,G,A */+  -940  -940  -940  -940    /* UG,GC,U,G,C */+  -310  -310  -310 -1560    /* UG,GC,U,G,G */+  -940  -940  -940  -940    /* UG,GC,U,G,U */+  -850  -850  -850  -850    /* UG,GC,U,U,A */+ -1470 -1470 -1470 -1470    /* UG,GC,U,U,C */+  -850  -850  -850  -850    /* UG,GC,U,U,G */+ -1140 -1140 -1140 -1140    /* UG,GC,U,U,U */+   -70 -1580 -2090 -1580    /* UG,GU,A,A,A */+  -890 -1400 -1910 -1400    /* UG,GU,A,A,C */+  -910 -1420 -1930 -1420    /* UG,GU,A,A,G */+  -890 -1400 -1910 -1400    /* UG,GU,A,A,U */+  -890 -1400 -1910 -1400    /* UG,GU,A,C,A */+  -890 -1400 -1670 -1400    /* UG,GU,A,C,C */+  -890 -1400 -1910 -1400    /* UG,GU,A,C,G */+  -890 -1400 -1670 -1400    /* UG,GU,A,C,U */+   -30 -1230 -1740 -1230    /* UG,GU,A,G,A */+  -890 -1400 -1910 -1400    /* UG,GU,A,G,C */+   360  -150 -1910  -150    /* UG,GU,A,G,G */+  -890 -1400 -1910 -1400    /* UG,GU,A,G,U */+  -890 -1400 -1910 -1400    /* UG,GU,A,U,A */+  -890 -1400 -1670 -1400    /* UG,GU,A,U,C */+  -890 -1400 -1910 -1400    /* UG,GU,A,U,G */+  -650 -1400 -1910 -1400    /* UG,GU,A,U,U */+ -1580 -1580 -1580 -1580    /* UG,GU,C,A,A */+ -1400 -1400 -1400 -1400    /* UG,GU,C,A,C */+ -1420 -1180 -1420 -1180    /* UG,GU,C,A,G */+ -1400 -1400 -1400 -1400    /* UG,GU,C,A,U */+ -1400 -1400 -1400 -1400    /* UG,GU,C,C,A */+ -1400 -1400 -1400 -1400    /* UG,GU,C,C,C */+ -1400 -1400 -1400 -1400    /* UG,GU,C,C,G */+ -1400 -1400 -1400 -1400    /* UG,GU,C,C,U */+ -1230  -990 -1230  -990    /* UG,GU,C,G,A */+ -1400 -1400 -1400 -1400    /* UG,GU,C,G,C */+  -150  -150  -150  -150    /* UG,GU,C,G,G */+ -1400 -1400 -1400 -1400    /* UG,GU,C,G,U */+ -1400 -1400 -1400 -1400    /* UG,GU,C,U,A */+ -1400 -1400 -1400 -1400    /* UG,GU,C,U,C */+ -1400 -1400 -1400 -1400    /* UG,GU,C,U,G */+ -1400 -1400 -1400 -1400    /* UG,GU,C,U,U */+ -1600 -1580  -330 -1580    /* UG,GU,G,A,A */+ -1740 -1400  -150 -1400    /* UG,GU,G,A,C */+ -3040 -1420 -1420 -1420    /* UG,GU,G,A,G */+ -1740 -1400  -150 -1400    /* UG,GU,G,A,U */+ -1740 -1400  -150 -1400    /* UG,GU,G,C,A */+ -1500 -1400  -150 -1400    /* UG,GU,G,C,C */+ -1740 -1400  -150 -1400    /* UG,GU,G,C,G */+ -1500 -1400  -150 -1400    /* UG,GU,G,C,U */+ -1570 -1230 -1230 -1230    /* UG,GU,G,G,A */+ -1740 -1400  -150 -1400    /* UG,GU,G,G,C */+ -1740  -150 -1400  -150    /* UG,GU,G,G,G */+ -1740 -1400  -150 -1400    /* UG,GU,G,G,U */+ -1740 -1400  -150 -1400    /* UG,GU,G,U,A */+ -1500 -1400  -150 -1400    /* UG,GU,G,U,C */+ -1740 -1400  -150 -1400    /* UG,GU,G,U,G */+ -1740 -1400 -1400 -1400    /* UG,GU,G,U,U */+ -1580 -1580 -1580 -1340    /* UG,GU,U,A,A */+ -1400 -1400 -1400 -1400    /* UG,GU,U,A,C */+ -1420 -1180 -1420 -1420    /* UG,GU,U,A,G */+ -1400 -1400 -1400 -1400    /* UG,GU,U,A,U */+ -1400 -1400 -1400 -1400    /* UG,GU,U,C,A */+ -1400 -1400 -1400 -1400    /* UG,GU,U,C,C */+ -1400 -1400 -1400 -1400    /* UG,GU,U,C,G */+ -1400 -1400 -1400 -1400    /* UG,GU,U,C,U */+ -1230  -990 -1230 -1230    /* UG,GU,U,G,A */+ -1400 -1400 -1400 -1400    /* UG,GU,U,G,C */+  -150  -150  -150 -1400    /* UG,GU,U,G,G */+ -1400 -1400 -1400 -1400    /* UG,GU,U,G,U */+ -1400 -1400 -1400 -1400    /* UG,GU,U,U,A */+ -1400 -1400 -1400 -1400    /* UG,GU,U,U,C */+ -1400 -1400 -1400 -1400    /* UG,GU,U,U,G */+ -1400 -1400 -1400 -1400    /* UG,GU,U,U,U */+   170  -340  -850  -340    /* UG,UG,A,A,A */+  -340  -850 -1360  -850    /* UG,UG,A,A,C */+  -680 -1190 -1700 -1190    /* UG,UG,A,A,G */+  -340  -850 -1360  -850    /* UG,UG,A,A,U */+  -340  -850 -1360  -850    /* UG,UG,A,C,A */+  -340  -850 -1120  -850    /* UG,UG,A,C,C */+  -340  -850 -1360  -850    /* UG,UG,A,C,G */+  -340  -850 -1120  -850    /* UG,UG,A,C,U */+  -850 -1360 -1870 -1360    /* UG,UG,A,G,A */+  -340  -850 -1360  -850    /* UG,UG,A,G,C */+   910   400 -1360   400    /* UG,UG,A,G,G */+  -340  -850 -1360  -850    /* UG,UG,A,G,U */+  -340  -850 -1360  -850    /* UG,UG,A,U,A */+  -340  -850 -1120  -850    /* UG,UG,A,U,C */+  -340  -850 -1360  -850    /* UG,UG,A,U,G */+  -100  -850 -1360  -850    /* UG,UG,A,U,U */+  -340  -340  -340  -340    /* UG,UG,C,A,A */+  -850  -850  -850  -850    /* UG,UG,C,A,C */+ -1190  -950 -1190  -950    /* UG,UG,C,A,G */+  -850  -850  -850  -850    /* UG,UG,C,A,U */+  -850  -850  -850  -850    /* UG,UG,C,C,A */+  -850  -850  -850  -850    /* UG,UG,C,C,C */+  -850  -850  -850  -850    /* UG,UG,C,C,G */+  -850  -850  -850  -850    /* UG,UG,C,C,U */+ -1360 -1120 -1360 -1120    /* UG,UG,C,G,A */+  -850  -850  -850  -850    /* UG,UG,C,G,C */+   400   400   400   400    /* UG,UG,C,G,G */+  -850  -850  -850  -850    /* UG,UG,C,G,U */+  -850  -850  -850  -850    /* UG,UG,C,U,A */+  -850  -850  -850  -850    /* UG,UG,C,U,C */+  -850  -850  -850  -850    /* UG,UG,C,U,G */+  -850  -850  -850  -850    /* UG,UG,C,U,U */+  -680  -340   910  -340    /* UG,UG,G,A,A */+ -1190  -850   400  -850    /* UG,UG,G,A,C */+ -1530 -1190 -1190 -1190    /* UG,UG,G,A,G */+ -1190  -850   400  -850    /* UG,UG,G,A,U */+ -1190  -850   400  -850    /* UG,UG,G,C,A */+  -950  -850   400  -850    /* UG,UG,G,C,C */+ -1190  -850   400  -850    /* UG,UG,G,C,G */+  -950  -850   400  -850    /* UG,UG,G,C,U */+ -1700 -1360 -1360 -1360    /* UG,UG,G,G,A */+ -1190  -850   400  -850    /* UG,UG,G,G,C */+ -1190   400  -850   400    /* UG,UG,G,G,G */+ -1190  -850   400  -850    /* UG,UG,G,G,U */+ -1190  -850   400  -850    /* UG,UG,G,U,A */+  -950  -850   400  -850    /* UG,UG,G,U,C */+ -1190  -850   400  -850    /* UG,UG,G,U,G */+ -1190  -850  -850  -850    /* UG,UG,G,U,U */+  -340  -340  -340  -100    /* UG,UG,U,A,A */+  -850  -850  -850  -850    /* UG,UG,U,A,C */+ -1190  -950 -1190 -1190    /* UG,UG,U,A,G */+  -850  -850  -850  -850    /* UG,UG,U,A,U */+  -850  -850  -850  -850    /* UG,UG,U,C,A */+  -850  -850  -850  -850    /* UG,UG,U,C,C */+  -850  -850  -850  -850    /* UG,UG,U,C,G */+  -850  -850  -850  -850    /* UG,UG,U,C,U */+ -1360 -1120 -1360 -1360    /* UG,UG,U,G,A */+  -850  -850  -850  -850    /* UG,UG,U,G,C */+   400   400   400  -850    /* UG,UG,U,G,G */+  -850  -850  -850  -850    /* UG,UG,U,G,U */+  -850  -850  -850  -850    /* UG,UG,U,U,A */+  -850  -850  -850  -850    /* UG,UG,U,U,C */+  -850  -850  -850  -850    /* UG,UG,U,U,G */+  -850  -850  -850  -850    /* UG,UG,U,U,U */+   750   240  -260   240    /* UG,AU,A,A,A */+   440   -60  -570   -60    /* UG,AU,A,A,C */+  -630 -1140 -1650 -1140    /* UG,AU,A,A,G */+   440   -60  -570   -60    /* UG,AU,A,A,U */+   460   -50  -560   -50    /* UG,AU,A,C,A */+   450   -50  -320   -50    /* UG,AU,A,C,C */+   460   -50  -560   -50    /* UG,AU,A,C,G */+   450   -50  -320   -50    /* UG,AU,A,C,U */+  -450  -960 -1470  -960    /* UG,AU,A,G,A */+   440   -60  -570   -60    /* UG,AU,A,G,C */+  1280   780  -980   780    /* UG,AU,A,G,G */+   440   -60  -570   -60    /* UG,AU,A,G,U */+   460   -50  -560   -50    /* UG,AU,A,U,A */+   450   -50  -320   -50    /* UG,AU,A,U,C */+   460   -50  -560   -50    /* UG,AU,A,U,G */+  -280 -1030 -1540 -1030    /* UG,AU,A,U,U */+   240   240   240   240    /* UG,AU,C,A,A */+   -60   -60   -60   -60    /* UG,AU,C,A,C */+ -1140  -900 -1140  -900    /* UG,AU,C,A,G */+   -60   -60   -60   -60    /* UG,AU,C,A,U */+   -50   -50   -50   -50    /* UG,AU,C,C,A */+   -50   -50   -50   -50    /* UG,AU,C,C,C */+   -50   -50   -50   -50    /* UG,AU,C,C,G */+   -50   -50   -50   -50    /* UG,AU,C,C,U */+  -960  -720  -960  -720    /* UG,AU,C,G,A */+   -60   -60   -60   -60    /* UG,AU,C,G,C */+   780   780   780   780    /* UG,AU,C,G,G */+   -60   -60   -60   -60    /* UG,AU,C,G,U */+   -50   -50   -50   -50    /* UG,AU,C,U,A */+   -50   -50   -50   -50    /* UG,AU,C,U,C */+   -50   -50   -50   -50    /* UG,AU,C,U,G */+ -1030 -1030 -1030 -1030    /* UG,AU,C,U,U */+   -90   240  1490   240    /* UG,AU,G,A,A */+  -400   -60  1190   -60    /* UG,AU,G,A,C */+ -1480 -1140 -1140 -1140    /* UG,AU,G,A,G */+  -400   -60  1190   -60    /* UG,AU,G,A,U */+  -390   -50  1200   -50    /* UG,AU,G,C,A */+  -150   -50  1200   -50    /* UG,AU,G,C,C */+  -390   -50  1200   -50    /* UG,AU,G,C,G */+  -150   -50  1200   -50    /* UG,AU,G,C,U */+ -1300  -960  -960  -960    /* UG,AU,G,G,A */+  -400   -60  1190   -60    /* UG,AU,G,G,C */+  -810   780  -470   780    /* UG,AU,G,G,G */+  -400   -60  1190   -60    /* UG,AU,G,G,U */+  -390   -50  1200   -50    /* UG,AU,G,U,A */+  -150   -50  1200   -50    /* UG,AU,G,U,C */+  -390   -50  1200   -50    /* UG,AU,G,U,G */+ -1370 -1030 -1030 -1030    /* UG,AU,G,U,U */+   240   240   240   480    /* UG,AU,U,A,A */+   -60   -60   -60   -60    /* UG,AU,U,A,C */+ -1140  -900 -1140 -1140    /* UG,AU,U,A,G */+   -60   -60   -60   -60    /* UG,AU,U,A,U */+   -50   -50   -50   -50    /* UG,AU,U,C,A */+   -50   -50   -50   -50    /* UG,AU,U,C,C */+   -50   -50   -50   -50    /* UG,AU,U,C,G */+   -50   -50   -50   -50    /* UG,AU,U,C,U */+  -960  -720  -960  -960    /* UG,AU,U,G,A */+   -60   -60   -60   -60    /* UG,AU,U,G,C */+   780   780   780  -470    /* UG,AU,U,G,G */+   -60   -60   -60   -60    /* UG,AU,U,G,U */+   -50   -50   -50   -50    /* UG,AU,U,U,A */+   -50   -50   -50   -50    /* UG,AU,U,U,C */+   -50   -50   -50   -50    /* UG,AU,U,U,G */+ -1030 -1030 -1030 -1030    /* UG,AU,U,U,U */+   820   310  -200   310    /* UG,UA,A,A,A */+   540    30  -480    30    /* UG,UA,A,A,C */+  -580 -1090 -1600 -1090    /* UG,UA,A,A,G */+   540    30  -480    30    /* UG,UA,A,A,U */+   690   180  -330   180    /* UG,UA,A,C,A */+   690   180   -90   180    /* UG,UA,A,C,C */+   690   180  -330   180    /* UG,UA,A,C,G */+   560    50  -220    50    /* UG,UA,A,C,U */+  -880 -1390 -1900 -1390    /* UG,UA,A,G,A */+   540    30  -480    30    /* UG,UA,A,G,C */+  1470   960  -800   960    /* UG,UA,A,G,G */+   540    30  -480    30    /* UG,UA,A,G,U */+   690   180  -330   180    /* UG,UA,A,U,A */+   250  -260  -530  -260    /* UG,UA,A,U,C */+   690   180  -330   180    /* UG,UA,A,U,G */+   -10  -760 -1270  -760    /* UG,UA,A,U,U */+   310   310   310   310    /* UG,UA,C,A,A */+    30    30    30    30    /* UG,UA,C,A,C */+ -1090  -850 -1090  -850    /* UG,UA,C,A,G */+    30    30    30    30    /* UG,UA,C,A,U */+   180   180   180   180    /* UG,UA,C,C,A */+   180   180   180   180    /* UG,UA,C,C,C */+   180   180   180   180    /* UG,UA,C,C,G */+    50    50    50    50    /* UG,UA,C,C,U */+ -1390 -1150 -1390 -1150    /* UG,UA,C,G,A */+    30    30    30    30    /* UG,UA,C,G,C */+   960   960   960   960    /* UG,UA,C,G,G */+    30    30    30    30    /* UG,UA,C,G,U */+   180   180   180   180    /* UG,UA,C,U,A */+  -260  -260  -260  -260    /* UG,UA,C,U,C */+   180   180   180   180    /* UG,UA,C,U,G */+  -760  -760  -760  -760    /* UG,UA,C,U,U */+   -30   310  1560   310    /* UG,UA,G,A,A */+  -310    30  1280    30    /* UG,UA,G,A,C */+ -1430 -1090 -1090 -1090    /* UG,UA,G,A,G */+  -310    30  1280    30    /* UG,UA,G,A,U */+  -160   180  1430   180    /* UG,UA,G,C,A */+    80   180  1430   180    /* UG,UA,G,C,C */+  -160   180  1430   180    /* UG,UA,G,C,G */+   -50    50  1300    50    /* UG,UA,G,C,U */+ -1730 -1390 -1390 -1390    /* UG,UA,G,G,A */+  -310    30  1280    30    /* UG,UA,G,G,C */+  -630   960  -290   960    /* UG,UA,G,G,G */+  -310    30  1280    30    /* UG,UA,G,G,U */+  -160   180  1430   180    /* UG,UA,G,U,A */+  -360  -260   990  -260    /* UG,UA,G,U,C */+  -160   180  1430   180    /* UG,UA,G,U,G */+ -1100  -760  -760  -760    /* UG,UA,G,U,U */+   310   310   310   550    /* UG,UA,U,A,A */+    30    30    30    30    /* UG,UA,U,A,C */+ -1090  -850 -1090 -1090    /* UG,UA,U,A,G */+    30    30    30    30    /* UG,UA,U,A,U */+   180   180   180   180    /* UG,UA,U,C,A */+   180   180   180   180    /* UG,UA,U,C,C */+   180   180   180   180    /* UG,UA,U,C,G */+    50    50    50    50    /* UG,UA,U,C,U */+ -1390 -1150 -1390 -1390    /* UG,UA,U,G,A */+    30    30    30    30    /* UG,UA,U,G,C */+   960   960   960  -290    /* UG,UA,U,G,G */+    30    30    30    30    /* UG,UA,U,G,U */+   180   180   180   180    /* UG,UA,U,U,A */+  -260  -260  -260  -260    /* UG,UA,U,U,C */+   180   180   180   180    /* UG,UA,U,U,G */+  -760  -760  -760  -760    /* UG,UA,U,U,U */+   440   140  -770   140    /* AU,CG,A,A,A */+   130  -160 -1080  -160    /* AU,CG,A,A,C */+   220   -70  -980   -70    /* AU,CG,A,A,G */+   130  -160 -1080  -160    /* AU,CG,A,A,U */+   580   290  -620   290    /* AU,CG,A,C,A */+   580   280  -390   280    /* AU,CG,A,C,C */+   580   290  -620   290    /* AU,CG,A,C,G */+   530   230  -440   230    /* AU,CG,A,C,U */+   -60  -350 -1270  -350    /* AU,CG,A,G,A */+   130  -160 -1080  -160    /* AU,CG,A,G,C */+   780   490 -1680   490    /* AU,CG,A,G,G */+   130  -160 -1080  -160    /* AU,CG,A,G,U */+   580   290  -620   290    /* AU,CG,A,U,A */+   640   340  -330   340    /* AU,CG,A,U,C */+   580   290  -620   290    /* AU,CG,A,U,G */+    40  -500 -1410  -500    /* AU,CG,A,U,U */+   130   140   130   140    /* AU,CG,C,A,A */+  -180  -170  -180  -170    /* AU,CG,C,A,C */+   -80   170   -80   170    /* AU,CG,C,A,G */+  -180  -170  -180  -170    /* AU,CG,C,A,U */+   270   280   270   280    /* AU,CG,C,C,A */+   270   280   270   280    /* AU,CG,C,C,C */+   270   280   270   280    /* AU,CG,C,C,G */+   220   230   220   230    /* AU,CG,C,C,U */+  -370  -120  -370  -120    /* AU,CG,C,G,A */+  -180  -170  -180  -170    /* AU,CG,C,G,C */+   470   480   470   480    /* AU,CG,C,G,G */+  -180  -170  -180  -170    /* AU,CG,C,G,U */+   270   280   270   280    /* AU,CG,C,U,A */+   330   340   330   340    /* AU,CG,C,U,C */+   270   280   270   280    /* AU,CG,C,U,G */+  -510  -500  -510  -500    /* AU,CG,C,U,U */+  -950   140   970   140    /* AU,CG,G,A,A */+ -1260  -160   660  -160    /* AU,CG,G,A,C */+ -1160   -70  -490   -70    /* AU,CG,G,A,G */+ -1260  -160   660  -160    /* AU,CG,G,A,U */+  -800   290  1120   290    /* AU,CG,G,C,A */+  -570   280  1110   280    /* AU,CG,G,C,C */+  -800   290  1120   290    /* AU,CG,G,C,G */+  -620   230  1060   230    /* AU,CG,G,C,U */+ -1450  -350  -780  -350    /* AU,CG,G,G,A */+ -1260  -160   660  -160    /* AU,CG,G,G,C */+ -1860   490 -1190   490    /* AU,CG,G,G,G */+ -1260  -160   660  -160    /* AU,CG,G,G,U */+  -800   290  1120   290    /* AU,CG,G,U,A */+  -510   340  1170   340    /* AU,CG,G,U,C */+  -800   290  1120   290    /* AU,CG,G,U,G */+ -1590  -500  -920  -500    /* AU,CG,G,U,U */+   130   140   130  -600    /* AU,CG,U,A,A */+  -180  -170  -180 -1150    /* AU,CG,U,A,C */+   -80   170   -80 -1050    /* AU,CG,U,A,G */+  -180  -170  -180 -1150    /* AU,CG,U,A,U */+   270   280   270  -690    /* AU,CG,U,C,A */+   270   280   270  -700    /* AU,CG,U,C,C */+   270   280   270  -690    /* AU,CG,U,C,G */+   220   230   220  -750    /* AU,CG,U,C,U */+  -370  -120  -370 -1340    /* AU,CG,U,G,A */+  -180  -170  -180 -1150    /* AU,CG,U,G,C */+   470   480   470 -1750    /* AU,CG,U,G,G */+  -180  -170  -180 -1150    /* AU,CG,U,G,U */+   270   280   270  -690    /* AU,CG,U,U,A */+   330   340   330  -640    /* AU,CG,U,U,C */+   270   280   270  -690    /* AU,CG,U,U,G */+  -510  -500  -510 -1480    /* AU,CG,U,U,U */+   600   310  -600   310    /* AU,GC,A,A,A */+   150  -140 -1050  -140    /* AU,GC,A,A,C */+  -580  -880 -1790  -880    /* AU,GC,A,A,G */+   150  -140 -1050  -140    /* AU,GC,A,A,U */+   240   -50  -970   -50    /* AU,GC,A,C,A */+   -60  -360 -1030  -360    /* AU,GC,A,C,C */+   240   -50  -970   -50    /* AU,GC,A,C,G */+   -60  -360 -1030  -360    /* AU,GC,A,C,U */+  -110  -400 -1320  -400    /* AU,GC,A,G,A */+   150  -140 -1050  -140    /* AU,GC,A,G,C */+   780   490 -1680   490    /* AU,GC,A,G,G */+   150  -140 -1050  -140    /* AU,GC,A,G,U */+   240   -50  -970   -50    /* AU,GC,A,U,A */+  -370  -670 -1340  -670    /* AU,GC,A,U,C */+   240   -50  -970   -50    /* AU,GC,A,U,G */+   190  -340 -1260  -340    /* AU,GC,A,U,U */+   290   300   290   300    /* AU,GC,C,A,A */+  -150  -140  -150  -140    /* AU,GC,C,A,C */+  -890  -640  -890  -640    /* AU,GC,C,A,G */+  -150  -140  -150  -140    /* AU,GC,C,A,U */+   -70   -60   -70   -60    /* AU,GC,C,C,A */+  -370  -360  -370  -360    /* AU,GC,C,C,C */+   -70   -60   -70   -60    /* AU,GC,C,C,G */+  -370  -360  -370  -360    /* AU,GC,C,C,U */+  -420  -170  -420  -170    /* AU,GC,C,G,A */+  -150  -140  -150  -140    /* AU,GC,C,G,C */+   470   480   470   480    /* AU,GC,C,G,G */+  -150  -140  -150  -140    /* AU,GC,C,G,U */+   -70   -60   -70   -60    /* AU,GC,C,U,A */+  -680  -670  -680  -670    /* AU,GC,C,U,C */+   -70   -60   -70   -60    /* AU,GC,C,U,G */+  -360  -350  -360  -350    /* AU,GC,C,U,U */+  -780   310  1140   310    /* AU,GC,G,A,A */+ -1230  -140   690  -140    /* AU,GC,G,A,C */+ -1970  -880 -1300  -880    /* AU,GC,G,A,G */+ -1230  -140   690  -140    /* AU,GC,G,A,U */+ -1150   -50   770   -50    /* AU,GC,G,C,A */+ -1210  -360   470  -360    /* AU,GC,G,C,C */+ -1150   -50   770   -50    /* AU,GC,G,C,G */+ -1210  -360   470  -360    /* AU,GC,G,C,U */+ -1500  -400  -830  -400    /* AU,GC,G,G,A */+ -1230  -140   690  -140    /* AU,GC,G,G,C */+ -1860   490 -1190   490    /* AU,GC,G,G,G */+ -1230  -140   690  -140    /* AU,GC,G,G,U */+ -1150   -50   770   -50    /* AU,GC,G,U,A */+ -1520  -670   160  -670    /* AU,GC,G,U,C */+ -1150   -50   770   -50    /* AU,GC,G,U,G */+ -1440  -340  -770  -340    /* AU,GC,G,U,U */+   290   300   290  -430    /* AU,GC,U,A,A */+  -150  -140  -150 -1120    /* AU,GC,U,A,C */+  -890  -640  -890 -1860    /* AU,GC,U,A,G */+  -150  -140  -150 -1120    /* AU,GC,U,A,U */+   -70   -60   -70 -1040    /* AU,GC,U,C,A */+  -370  -360  -370 -1340    /* AU,GC,U,C,C */+   -70   -60   -70 -1040    /* AU,GC,U,C,G */+  -370  -360  -370 -1340    /* AU,GC,U,C,U */+  -420  -170  -420 -1390    /* AU,GC,U,G,A */+  -150  -140  -150 -1120    /* AU,GC,U,G,C */+   470   480   470 -1750    /* AU,GC,U,G,G */+  -150  -140  -150 -1120    /* AU,GC,U,G,U */+   -70   -60   -70 -1040    /* AU,GC,U,U,A */+  -680  -670  -680 -1650    /* AU,GC,U,U,C */+   -70   -60   -70 -1040    /* AU,GC,U,U,G */+  -360  -350  -360 -1330    /* AU,GC,U,U,U */+  -490  -780 -1700  -780    /* AU,GU,A,A,A */+  -310  -600 -1520  -600    /* AU,GU,A,A,C */+  -320  -620 -1530  -620    /* AU,GU,A,A,G */+  -310  -600 -1520  -600    /* AU,GU,A,A,U */+  -310  -600 -1520  -600    /* AU,GU,A,C,A */+  -310  -600 -1280  -600    /* AU,GU,A,C,C */+  -310  -600 -1520  -600    /* AU,GU,A,C,G */+  -310  -600 -1280  -600    /* AU,GU,A,C,U */+  -130  -430 -1340  -430    /* AU,GU,A,G,A */+  -310  -600 -1520  -600    /* AU,GU,A,G,C */+   940   650 -1520   650    /* AU,GU,A,G,G */+  -310  -600 -1520  -600    /* AU,GU,A,G,U */+  -310  -600 -1520  -600    /* AU,GU,A,U,A */+  -310  -600 -1280  -600    /* AU,GU,A,U,C */+  -310  -600 -1520  -600    /* AU,GU,A,U,G */+   -70  -600 -1520  -600    /* AU,GU,A,U,U */+  -800  -790  -800  -790    /* AU,GU,C,A,A */+  -620  -610  -620  -610    /* AU,GU,C,A,C */+  -630  -380  -630  -380    /* AU,GU,C,A,G */+  -620  -610  -620  -610    /* AU,GU,C,A,U */+  -620  -610  -620  -610    /* AU,GU,C,C,A */+  -620  -610  -620  -610    /* AU,GU,C,C,C */+  -620  -610  -620  -610    /* AU,GU,C,C,G */+  -620  -610  -620  -610    /* AU,GU,C,C,U */+  -440  -190  -440  -190    /* AU,GU,C,G,A */+  -620  -610  -620  -610    /* AU,GU,C,G,C */+   630   640   630   640    /* AU,GU,C,G,G */+  -620  -610  -620  -610    /* AU,GU,C,G,U */+  -620  -610  -620  -610    /* AU,GU,C,U,A */+  -620  -610  -620  -610    /* AU,GU,C,U,C */+  -620  -610  -620  -610    /* AU,GU,C,U,G */+  -620  -610  -620  -610    /* AU,GU,C,U,U */+ -1880  -780    40  -780    /* AU,GU,G,A,A */+ -1700  -600   220  -600    /* AU,GU,G,A,C */+ -1710  -620 -1040  -620    /* AU,GU,G,A,G */+ -1700  -600   220  -600    /* AU,GU,G,A,U */+ -1700  -600   220  -600    /* AU,GU,G,C,A */+ -1460  -600   220  -600    /* AU,GU,G,C,C */+ -1700  -600   220  -600    /* AU,GU,G,C,G */+ -1460  -600   220  -600    /* AU,GU,G,C,U */+ -1520  -430  -850  -430    /* AU,GU,G,G,A */+ -1700  -600   220  -600    /* AU,GU,G,G,C */+ -1700   650 -1030   650    /* AU,GU,G,G,G */+ -1700  -600   220  -600    /* AU,GU,G,G,U */+ -1700  -600   220  -600    /* AU,GU,G,U,A */+ -1460  -600   220  -600    /* AU,GU,G,U,C */+ -1700  -600   220  -600    /* AU,GU,G,U,G */+ -1700  -600 -1030  -600    /* AU,GU,G,U,U */+  -800  -790  -800 -1530    /* AU,GU,U,A,A */+  -620  -610  -620 -1590    /* AU,GU,U,A,C */+  -630  -380  -630 -1600    /* AU,GU,U,A,G */+  -620  -610  -620 -1590    /* AU,GU,U,A,U */+  -620  -610  -620 -1590    /* AU,GU,U,C,A */+  -620  -610  -620 -1590    /* AU,GU,U,C,C */+  -620  -610  -620 -1590    /* AU,GU,U,C,G */+  -620  -610  -620 -1590    /* AU,GU,U,C,U */+  -440  -190  -440 -1410    /* AU,GU,U,G,A */+  -620  -610  -620 -1590    /* AU,GU,U,G,C */+   630   640   630 -1590    /* AU,GU,U,G,G */+  -620  -610  -620 -1590    /* AU,GU,U,G,U */+  -620  -610  -620 -1590    /* AU,GU,U,U,A */+  -620  -610  -620 -1590    /* AU,GU,U,U,C */+  -620  -610  -620 -1590    /* AU,GU,U,U,G */+  -620  -610  -620 -1590    /* AU,GU,U,U,U */+   750   460  -450   460    /* AU,UG,A,A,A */+   240   -50  -960   -50    /* AU,UG,A,A,C */+   -90  -390 -1300  -390    /* AU,UG,A,A,G */+   240   -50  -960   -50    /* AU,UG,A,A,U */+   240   -50  -960   -50    /* AU,UG,A,C,A */+   240   -50  -720   -50    /* AU,UG,A,C,C */+   240   -50  -960   -50    /* AU,UG,A,C,G */+   240   -50  -720   -50    /* AU,UG,A,C,U */+  -260  -560 -1470  -560    /* AU,UG,A,G,A */+   240   -50  -960   -50    /* AU,UG,A,G,C */+  1490  1200  -960  1200    /* AU,UG,A,G,G */+   240   -50  -960   -50    /* AU,UG,A,G,U */+   240   -50  -960   -50    /* AU,UG,A,U,A */+   240   -50  -720   -50    /* AU,UG,A,U,C */+   240   -50  -960   -50    /* AU,UG,A,U,G */+   480   -50  -960   -50    /* AU,UG,A,U,U */+   440   450   440   450    /* AU,UG,C,A,A */+   -60   -50   -60   -50    /* AU,UG,C,A,C */+  -400  -150  -400  -150    /* AU,UG,C,A,G */+   -60   -50   -60   -50    /* AU,UG,C,A,U */+   -60   -50   -60   -50    /* AU,UG,C,C,A */+   -60   -50   -60   -50    /* AU,UG,C,C,C */+   -60   -50   -60   -50    /* AU,UG,C,C,G */+   -60   -50   -60   -50    /* AU,UG,C,C,U */+  -570  -320  -570  -320    /* AU,UG,C,G,A */+   -60   -50   -60   -50    /* AU,UG,C,G,C */+  1190  1200  1190  1200    /* AU,UG,C,G,G */+   -60   -50   -60   -50    /* AU,UG,C,G,U */+   -60   -50   -60   -50    /* AU,UG,C,U,A */+   -60   -50   -60   -50    /* AU,UG,C,U,C */+   -60   -50   -60   -50    /* AU,UG,C,U,G */+   -60   -50   -60   -50    /* AU,UG,C,U,U */+  -630   460  1280   460    /* AU,UG,G,A,A */+ -1140   -50   780   -50    /* AU,UG,G,A,C */+ -1480  -390  -810  -390    /* AU,UG,G,A,G */+ -1140   -50   780   -50    /* AU,UG,G,A,U */+ -1140   -50   780   -50    /* AU,UG,G,C,A */+  -900   -50   780   -50    /* AU,UG,G,C,C */+ -1140   -50   780   -50    /* AU,UG,G,C,G */+  -900   -50   780   -50    /* AU,UG,G,C,U */+ -1650  -560  -980  -560    /* AU,UG,G,G,A */+ -1140   -50   780   -50    /* AU,UG,G,G,C */+ -1140  1200  -470  1200    /* AU,UG,G,G,G */+ -1140   -50   780   -50    /* AU,UG,G,G,U */+ -1140   -50   780   -50    /* AU,UG,G,U,A */+  -900   -50   780   -50    /* AU,UG,G,U,C */+ -1140   -50   780   -50    /* AU,UG,G,U,G */+ -1140   -50  -470   -50    /* AU,UG,G,U,U */+   440   450   440  -280    /* AU,UG,U,A,A */+   -60   -50   -60 -1030    /* AU,UG,U,A,C */+  -400  -150  -400 -1370    /* AU,UG,U,A,G */+   -60   -50   -60 -1030    /* AU,UG,U,A,U */+   -60   -50   -60 -1030    /* AU,UG,U,C,A */+   -60   -50   -60 -1030    /* AU,UG,U,C,C */+   -60   -50   -60 -1030    /* AU,UG,U,C,G */+   -60   -50   -60 -1030    /* AU,UG,U,C,U */+  -570  -320  -570 -1540    /* AU,UG,U,G,A */+   -60   -50   -60 -1030    /* AU,UG,U,G,C */+  1190  1200  1190 -1030    /* AU,UG,U,G,G */+   -60   -50   -60 -1030    /* AU,UG,U,G,U */+   -60   -50   -60 -1030    /* AU,UG,U,U,A */+   -60   -50   -60 -1030    /* AU,UG,U,U,C */+   -60   -50   -60 -1030    /* AU,UG,U,U,G */+   -60   -50   -60 -1030    /* AU,UG,U,U,U */+  1340  1040   130  1040    /* AU,AU,A,A,A */+  1030   730  -180   730    /* AU,AU,A,A,C */+   -50  -340 -1260  -340    /* AU,AU,A,A,G */+  1030   730  -180   730    /* AU,AU,A,A,U */+  1040   750  -160   750    /* AU,AU,A,C,A */+  1040   740    70   740    /* AU,AU,A,C,C */+  1040   750  -160   750    /* AU,AU,A,C,G */+  1040   740    70   740    /* AU,AU,A,C,U */+   130  -160 -1080  -160    /* AU,AU,A,G,A */+  1030   730  -180   730    /* AU,AU,A,G,C */+  1870  1570  -590  1570    /* AU,AU,A,G,G */+  1030   730  -180   730    /* AU,AU,A,G,U */+  1040   750  -160   750    /* AU,AU,A,U,A */+  1040   740    70   740    /* AU,AU,A,U,C */+  1040   750  -160   750    /* AU,AU,A,U,G */+   300  -230 -1150  -230    /* AU,AU,A,U,U */+  1030  1040  1030  1040    /* AU,AU,C,A,A */+   720   730   720   730    /* AU,AU,C,A,C */+  -360  -110  -360  -110    /* AU,AU,C,A,G */+   720   730   720   730    /* AU,AU,C,A,U */+   730   740   730   740    /* AU,AU,C,C,A */+   730   740   730   740    /* AU,AU,C,C,C */+   730   740   730   740    /* AU,AU,C,C,G */+   730   740   730   740    /* AU,AU,C,C,U */+  -180    70  -180    70    /* AU,AU,C,G,A */+   720   730   720   730    /* AU,AU,C,G,C */+  1560  1570  1560  1570    /* AU,AU,C,G,G */+   720   730   720   730    /* AU,AU,C,G,U */+   730   740   730   740    /* AU,AU,C,U,A */+   730   740   730   740    /* AU,AU,C,U,C */+   730   740   730   740    /* AU,AU,C,U,G */+  -250  -240  -250  -240    /* AU,AU,C,U,U */+   -50  1040  1870  1040    /* AU,AU,G,A,A */+  -360   730  1560   730    /* AU,AU,G,A,C */+ -1440  -340  -770  -340    /* AU,AU,G,A,G */+  -360   730  1560   730    /* AU,AU,G,A,U */+  -340   750  1570   750    /* AU,AU,G,C,A */+  -110   740  1570   740    /* AU,AU,G,C,C */+  -340   750  1570   750    /* AU,AU,G,C,G */+  -110   740  1570   740    /* AU,AU,G,C,U */+ -1260  -160  -590  -160    /* AU,AU,G,G,A */+  -360   730  1560   730    /* AU,AU,G,G,C */+  -770  1570  -100  1570    /* AU,AU,G,G,G */+  -360   730  1560   730    /* AU,AU,G,G,U */+  -340   750  1570   750    /* AU,AU,G,U,A */+  -110   740  1570   740    /* AU,AU,G,U,C */+  -340   750  1570   750    /* AU,AU,G,U,G */+ -1330  -230  -660  -230    /* AU,AU,G,U,U */+  1030  1040  1030   300    /* AU,AU,U,A,A */+   720   730   720  -250    /* AU,AU,U,A,C */+  -360  -110  -360 -1330    /* AU,AU,U,A,G */+   720   730   720  -250    /* AU,AU,U,A,U */+   730   740   730  -230    /* AU,AU,U,C,A */+   730   740   730  -240    /* AU,AU,U,C,C */+   730   740   730  -230    /* AU,AU,U,C,G */+   730   740   730  -240    /* AU,AU,U,C,U */+  -180    70  -180 -1150    /* AU,AU,U,G,A */+   720   730   720  -250    /* AU,AU,U,G,C */+  1560  1570  1560  -660    /* AU,AU,U,G,G */+   720   730   720  -250    /* AU,AU,U,G,U */+   730   740   730  -230    /* AU,AU,U,U,A */+   730   740   730  -240    /* AU,AU,U,U,C */+   730   740   730  -230    /* AU,AU,U,U,G */+  -250  -240  -250 -1220    /* AU,AU,U,U,U */+  1400  1110   190  1110    /* AU,UA,A,A,A */+  1120   830   -80   830    /* AU,UA,A,A,C */+     0  -290 -1210  -290    /* AU,UA,A,A,G */+  1120   830   -80   830    /* AU,UA,A,A,U */+  1270   980    60   980    /* AU,UA,A,C,A */+  1270   980   300   980    /* AU,UA,A,C,C */+  1270   980    60   980    /* AU,UA,A,C,G */+  1140   850   180   850    /* AU,UA,A,C,U */+  -300  -590 -1510  -590    /* AU,UA,A,G,A */+  1120   830   -80   830    /* AU,UA,A,G,C */+  2050  1760  -400  1760    /* AU,UA,A,G,G */+  1120   830   -80   830    /* AU,UA,A,G,U */+  1270   980    60   980    /* AU,UA,A,U,A */+   830   540  -130   540    /* AU,UA,A,U,C */+  1270   980    60   980    /* AU,UA,A,U,G */+   570    40  -870    40    /* AU,UA,A,U,U */+  1090  1100  1090  1100    /* AU,UA,C,A,A */+   810   820   810   820    /* AU,UA,C,A,C */+  -310   -60  -310   -60    /* AU,UA,C,A,G */+   810   820   810   820    /* AU,UA,C,A,U */+   960   970   960   970    /* AU,UA,C,C,A */+   960   970   960   970    /* AU,UA,C,C,C */+   960   970   960   970    /* AU,UA,C,C,G */+   830   840   830   840    /* AU,UA,C,C,U */+  -610  -360  -610  -360    /* AU,UA,C,G,A */+   810   820   810   820    /* AU,UA,C,G,C */+  1740  1750  1740  1750    /* AU,UA,C,G,G */+   810   820   810   820    /* AU,UA,C,G,U */+   960   970   960   970    /* AU,UA,C,U,A */+   520   530   520   530    /* AU,UA,C,U,C */+   960   970   960   970    /* AU,UA,C,U,G */+    20    30    20    30    /* AU,UA,C,U,U */+    10  1110  1930  1110    /* AU,UA,G,A,A */+  -260   830  1650   830    /* AU,UA,G,A,C */+ -1390  -290  -720  -290    /* AU,UA,G,A,G */+  -260   830  1650   830    /* AU,UA,G,A,U */+  -110   980  1800   980    /* AU,UA,G,C,A */+   130   980  1800   980    /* AU,UA,G,C,C */+  -110   980  1800   980    /* AU,UA,G,C,G */+     0   850  1670   850    /* AU,UA,G,C,U */+ -1690  -590 -1020  -590    /* AU,UA,G,G,A */+  -260   830  1650   830    /* AU,UA,G,G,C */+  -580  1760    80  1760    /* AU,UA,G,G,G */+  -260   830  1650   830    /* AU,UA,G,G,U */+  -110   980  1800   980    /* AU,UA,G,U,A */+  -310   540  1360   540    /* AU,UA,G,U,C */+  -110   980  1800   980    /* AU,UA,G,U,G */+ -1050    40  -380    40    /* AU,UA,G,U,U */+  1090  1100  1090   360    /* AU,UA,U,A,A */+   810   820   810  -150    /* AU,UA,U,A,C */+  -310   -60  -310 -1280    /* AU,UA,U,A,G */+   810   820   810  -150    /* AU,UA,U,A,U */+   960   970   960     0    /* AU,UA,U,C,A */+   960   970   960     0    /* AU,UA,U,C,C */+   960   970   960     0    /* AU,UA,U,C,G */+   830   840   830  -130    /* AU,UA,U,C,U */+  -610  -360  -610 -1580    /* AU,UA,U,G,A */+   810   820   810  -150    /* AU,UA,U,G,C */+  1740  1750  1740  -470    /* AU,UA,U,G,G */+   810   820   810  -150    /* AU,UA,U,G,U */+   960   970   960     0    /* AU,UA,U,U,A */+   520   530   520  -440    /* AU,UA,U,U,C */+   960   970   960     0    /* AU,UA,U,U,G */+    20    30    20  -940    /* AU,UA,U,U,U */+   500   370 -1200   370    /* UA,CG,A,A,A */+   190    60 -1510    60    /* UA,CG,A,A,C */+   290   160 -1410   160    /* UA,CG,A,A,G */+   190    60 -1510    60    /* UA,CG,A,A,U */+   650   520 -1050   520    /* UA,CG,A,C,A */+   640   510  -820   510    /* UA,CG,A,C,C */+   650   520 -1050   520    /* UA,CG,A,C,G */+   590   460  -870   460    /* UA,CG,A,C,U */+     0  -120 -1700  -120    /* UA,CG,A,G,A */+   190    60 -1510    60    /* UA,CG,A,G,C */+   850   720 -2110   720    /* UA,CG,A,G,G */+   190    60 -1510    60    /* UA,CG,A,G,U */+   650   520 -1050   520    /* UA,CG,A,U,A */+   700   570  -760   570    /* UA,CG,A,U,C */+   650   520 -1050   520    /* UA,CG,A,U,G */+   100  -270 -1840  -270    /* UA,CG,A,U,U */+   220   370   220   -60    /* UA,CG,C,A,A */+   -80    60   -80  -370    /* UA,CG,C,A,C */+    10   400    10   -40    /* UA,CG,C,A,G */+   -80    60   -80  -370    /* UA,CG,C,A,U */+   370   520   370    80    /* UA,CG,C,C,A */+   360   510   360    70    /* UA,CG,C,C,C */+   370   520   370    80    /* UA,CG,C,C,G */+   310   460   310    20    /* UA,CG,C,C,U */+  -270   120  -270  -320    /* UA,CG,C,G,A */+   -80    60   -80  -370    /* UA,CG,C,G,C */+   570   720   570   280    /* UA,CG,C,G,G */+   -80    60   -80  -370    /* UA,CG,C,G,U */+   370   520   370    80    /* UA,CG,C,U,A */+   420   570   420   130    /* UA,CG,C,U,C */+   370   520   370    80    /* UA,CG,C,U,G */+  -420  -270  -420  -710    /* UA,CG,C,U,U */+  -900   370  1160   370    /* UA,CG,G,A,A */+ -1210    60   850    60    /* UA,CG,G,A,C */+ -1110   160  -310   160    /* UA,CG,G,A,G */+ -1210    60   850    60    /* UA,CG,G,A,U */+  -750   520  1300   520    /* UA,CG,G,C,A */+  -520   510  1290   510    /* UA,CG,G,C,C */+  -750   520  1300   520    /* UA,CG,G,C,G */+  -570   460  1250   460    /* UA,CG,G,C,U */+ -1400  -120  -590  -120    /* UA,CG,G,G,A */+ -1210    60   850    60    /* UA,CG,G,G,C */+ -1810   720 -1000   720    /* UA,CG,G,G,G */+ -1210    60   850    60    /* UA,CG,G,G,U */+  -750   520  1300   520    /* UA,CG,G,U,A */+  -460   570  1350   570    /* UA,CG,G,U,C */+  -750   520  1300   520    /* UA,CG,G,U,G */+ -1540  -270  -740  -270    /* UA,CG,G,U,U */+   220   240   220  -320    /* UA,CG,U,A,A */+   -80   -60   -80  -870    /* UA,CG,U,A,C */+    10   270    10  -780    /* UA,CG,U,A,G */+   -80   -60   -80  -870    /* UA,CG,U,A,U */+   370   390   370  -420    /* UA,CG,U,C,A */+   360   380   360  -420    /* UA,CG,U,C,C */+   370   390   370  -420    /* UA,CG,U,C,G */+   310   330   310  -470    /* UA,CG,U,C,U */+  -270   -10  -270 -1060    /* UA,CG,U,G,A */+   -80   -60   -80  -870    /* UA,CG,U,G,C */+   570   590   570 -1470    /* UA,CG,U,G,G */+   -80   -60   -80  -870    /* UA,CG,U,G,U */+   370   390   370  -420    /* UA,CG,U,U,A */+   420   440   420  -360    /* UA,CG,U,U,C */+   370   390   370  -420    /* UA,CG,U,U,G */+  -420  -400  -420 -1210    /* UA,CG,U,U,U */+   670   540 -1030   540    /* UA,GC,A,A,A */+   220    90 -1480    90    /* UA,GC,A,A,C */+  -520  -650 -2220  -650    /* UA,GC,A,A,G */+   220    90 -1480    90    /* UA,GC,A,A,U */+   300   170 -1400   170    /* UA,GC,A,C,A */+     0  -130 -1460  -130    /* UA,GC,A,C,C */+   300   170 -1400   170    /* UA,GC,A,C,G */+     0  -130 -1460  -130    /* UA,GC,A,C,U */+   -40  -170 -1750  -170    /* UA,GC,A,G,A */+   220    90 -1480    90    /* UA,GC,A,G,C */+   850   720 -2110   720    /* UA,GC,A,G,G */+   220    90 -1480    90    /* UA,GC,A,G,U */+   300   170 -1400   170    /* UA,GC,A,U,A */+  -310  -440 -1770  -440    /* UA,GC,A,U,C */+   300   170 -1400   170    /* UA,GC,A,U,G */+   250  -110 -1690  -110    /* UA,GC,A,U,U */+   390   540   390   100    /* UA,GC,C,A,A */+   -60    90   -60  -350    /* UA,GC,C,A,C */+  -800  -410  -800  -850    /* UA,GC,C,A,G */+   -60    90   -60  -350    /* UA,GC,C,A,U */+    20   170    20  -260    /* UA,GC,C,C,A */+  -280  -130  -280  -570    /* UA,GC,C,C,C */+    20   170    20  -260    /* UA,GC,C,C,G */+  -280  -130  -280  -570    /* UA,GC,C,C,U */+  -320    70  -320  -370    /* UA,GC,C,G,A */+   -60    90   -60  -350    /* UA,GC,C,G,C */+   570   720   570   280    /* UA,GC,C,G,G */+   -60    90   -60  -350    /* UA,GC,C,G,U */+    20   170    20  -260    /* UA,GC,C,U,A */+  -590  -440  -590  -880    /* UA,GC,C,U,C */+    20   170    20  -260    /* UA,GC,C,U,G */+  -260  -110  -260  -550    /* UA,GC,C,U,U */+  -730   540  1320   540    /* UA,GC,G,A,A */+ -1180    90   870    90    /* UA,GC,G,A,C */+ -1920  -650 -1120  -650    /* UA,GC,G,A,G */+ -1180    90   870    90    /* UA,GC,G,A,U */+ -1100   170   960   170    /* UA,GC,G,C,A */+ -1160  -130   650  -130    /* UA,GC,G,C,C */+ -1100   170   960   170    /* UA,GC,G,C,G */+ -1160  -130   650  -130    /* UA,GC,G,C,U */+ -1450  -170  -640  -170    /* UA,GC,G,G,A */+ -1180    90   870    90    /* UA,GC,G,G,C */+ -1810   720 -1000   720    /* UA,GC,G,G,G */+ -1180    90   870    90    /* UA,GC,G,G,U */+ -1100   170   960   170    /* UA,GC,G,U,A */+ -1470  -440   340  -440    /* UA,GC,G,U,C */+ -1100   170   960   170    /* UA,GC,G,U,G */+ -1390  -110  -580  -110    /* UA,GC,G,U,U */+   390   410   390  -160    /* UA,GC,U,A,A */+   -60   -40   -60  -850    /* UA,GC,U,A,C */+  -800  -540  -800 -1590    /* UA,GC,U,A,G */+   -60   -40   -60  -850    /* UA,GC,U,A,U */+    20    40    20  -760    /* UA,GC,U,C,A */+  -280  -260  -280 -1070    /* UA,GC,U,C,C */+    20    40    20  -760    /* UA,GC,U,C,G */+  -280  -260  -280 -1070    /* UA,GC,U,C,U */+  -320   -60  -320 -1110    /* UA,GC,U,G,A */+   -60   -40   -60  -850    /* UA,GC,U,G,C */+   570   590   570 -1470    /* UA,GC,U,G,G */+   -60   -40   -60  -850    /* UA,GC,U,G,U */+    20    40    20  -760    /* UA,GC,U,U,A */+  -590  -570  -590 -1380    /* UA,GC,U,U,C */+    20    40    20  -760    /* UA,GC,U,U,G */+  -260  -240  -260 -1050    /* UA,GC,U,U,U */+  -420  -550 -2130  -550    /* UA,GU,A,A,A */+  -240  -370 -1950  -370    /* UA,GU,A,A,C */+  -260  -390 -1960  -390    /* UA,GU,A,A,G */+  -240  -370 -1950  -370    /* UA,GU,A,A,U */+  -240  -370 -1950  -370    /* UA,GU,A,C,A */+  -240  -370 -1710  -370    /* UA,GU,A,C,C */+  -240  -370 -1950  -370    /* UA,GU,A,C,G */+  -240  -370 -1710  -370    /* UA,GU,A,C,U */+   -70  -200 -1770  -200    /* UA,GU,A,G,A */+  -240  -370 -1950  -370    /* UA,GU,A,G,C */+  1010   880 -1950   880    /* UA,GU,A,G,G */+  -240  -370 -1950  -370    /* UA,GU,A,G,U */+  -240  -370 -1950  -370    /* UA,GU,A,U,A */+  -240  -370 -1710  -370    /* UA,GU,A,U,C */+  -240  -370 -1950  -370    /* UA,GU,A,U,G */+     0  -370 -1950  -370    /* UA,GU,A,U,U */+  -700  -550  -700  -990    /* UA,GU,C,A,A */+  -520  -370  -520  -810    /* UA,GU,C,A,C */+  -540  -150  -540  -590    /* UA,GU,C,A,G */+  -520  -370  -520  -810    /* UA,GU,C,A,U */+  -520  -370  -520  -810    /* UA,GU,C,C,A */+  -520  -370  -520  -810    /* UA,GU,C,C,C */+  -520  -370  -520  -810    /* UA,GU,C,C,G */+  -520  -370  -520  -810    /* UA,GU,C,C,U */+  -350    40  -350  -400    /* UA,GU,C,G,A */+  -520  -370  -520  -810    /* UA,GU,C,G,C */+   730   880   730   440    /* UA,GU,C,G,G */+  -520  -370  -520  -810    /* UA,GU,C,G,U */+  -520  -370  -520  -810    /* UA,GU,C,U,A */+  -520  -370  -520  -810    /* UA,GU,C,U,C */+  -520  -370  -520  -810    /* UA,GU,C,U,G */+  -520  -370  -520  -810    /* UA,GU,C,U,U */+ -1830  -550   230  -550    /* UA,GU,G,A,A */+ -1650  -370   410  -370    /* UA,GU,G,A,C */+ -1660  -390  -860  -390    /* UA,GU,G,A,G */+ -1650  -370   410  -370    /* UA,GU,G,A,U */+ -1650  -370   410  -370    /* UA,GU,G,C,A */+ -1410  -370   410  -370    /* UA,GU,G,C,C */+ -1650  -370   410  -370    /* UA,GU,G,C,G */+ -1410  -370   410  -370    /* UA,GU,G,C,U */+ -1470  -200  -670  -200    /* UA,GU,G,G,A */+ -1650  -370   410  -370    /* UA,GU,G,G,C */+ -1650   880  -840   880    /* UA,GU,G,G,G */+ -1650  -370   410  -370    /* UA,GU,G,G,U */+ -1650  -370   410  -370    /* UA,GU,G,U,A */+ -1410  -370   410  -370    /* UA,GU,G,U,C */+ -1650  -370   410  -370    /* UA,GU,G,U,G */+ -1650  -370  -840  -370    /* UA,GU,G,U,U */+  -700  -680  -700 -1250    /* UA,GU,U,A,A */+  -520  -500  -520 -1310    /* UA,GU,U,A,C */+  -540  -280  -540 -1330    /* UA,GU,U,A,G */+  -520  -500  -520 -1310    /* UA,GU,U,A,U */+  -520  -500  -520 -1310    /* UA,GU,U,C,A */+  -520  -500  -520 -1310    /* UA,GU,U,C,C */+  -520  -500  -520 -1310    /* UA,GU,U,C,G */+  -520  -500  -520 -1310    /* UA,GU,U,C,U */+  -350   -90  -350 -1140    /* UA,GU,U,G,A */+  -520  -500  -520 -1310    /* UA,GU,U,G,C */+   730   750   730 -1310    /* UA,GU,U,G,G */+  -520  -500  -520 -1310    /* UA,GU,U,G,U */+  -520  -500  -520 -1310    /* UA,GU,U,U,A */+  -520  -500  -520 -1310    /* UA,GU,U,U,C */+  -520  -500  -520 -1310    /* UA,GU,U,U,G */+  -520  -500  -520 -1310    /* UA,GU,U,U,U */+   820   690  -880   690    /* UA,UG,A,A,A */+   310   180 -1390   180    /* UA,UG,A,A,C */+   -30  -160 -1730  -160    /* UA,UG,A,A,G */+   310   180 -1390   180    /* UA,UG,A,A,U */+   310   180 -1390   180    /* UA,UG,A,C,A */+   310   180 -1150   180    /* UA,UG,A,C,C */+   310   180 -1390   180    /* UA,UG,A,C,G */+   310   180 -1150   180    /* UA,UG,A,C,U */+  -200  -330 -1900  -330    /* UA,UG,A,G,A */+   310   180 -1390   180    /* UA,UG,A,G,C */+  1560  1430 -1390  1430    /* UA,UG,A,G,G */+   310   180 -1390   180    /* UA,UG,A,G,U */+   310   180 -1390   180    /* UA,UG,A,U,A */+   310   180 -1150   180    /* UA,UG,A,U,C */+   310   180 -1390   180    /* UA,UG,A,U,G */+   550   180 -1390   180    /* UA,UG,A,U,U */+   540   690   540   250    /* UA,UG,C,A,A */+    30   180    30  -260    /* UA,UG,C,A,C */+  -310    80  -310  -360    /* UA,UG,C,A,G */+    30   180    30  -260    /* UA,UG,C,A,U */+    30   180    30  -260    /* UA,UG,C,C,A */+    30   180    30  -260    /* UA,UG,C,C,C */+    30   180    30  -260    /* UA,UG,C,C,G */+    30   180    30  -260    /* UA,UG,C,C,U */+  -480   -90  -480  -530    /* UA,UG,C,G,A */+    30   180    30  -260    /* UA,UG,C,G,C */+  1280  1430  1280   990    /* UA,UG,C,G,G */+    30   180    30  -260    /* UA,UG,C,G,U */+    30   180    30  -260    /* UA,UG,C,U,A */+    30   180    30  -260    /* UA,UG,C,U,C */+    30   180    30  -260    /* UA,UG,C,U,G */+    30   180    30  -260    /* UA,UG,C,U,U */+  -580   690  1470   690    /* UA,UG,G,A,A */+ -1090   180   960   180    /* UA,UG,G,A,C */+ -1430  -160  -630  -160    /* UA,UG,G,A,G */+ -1090   180   960   180    /* UA,UG,G,A,U */+ -1090   180   960   180    /* UA,UG,G,C,A */+  -850   180   960   180    /* UA,UG,G,C,C */+ -1090   180   960   180    /* UA,UG,G,C,G */+  -850   180   960   180    /* UA,UG,G,C,U */+ -1600  -330  -800  -330    /* UA,UG,G,G,A */+ -1090   180   960   180    /* UA,UG,G,G,C */+ -1090  1430  -290  1430    /* UA,UG,G,G,G */+ -1090   180   960   180    /* UA,UG,G,G,U */+ -1090   180   960   180    /* UA,UG,G,U,A */+  -850   180   960   180    /* UA,UG,G,U,C */+ -1090   180   960   180    /* UA,UG,G,U,G */+ -1090   180  -290   180    /* UA,UG,G,U,U */+   540   560   540   -10    /* UA,UG,U,A,A */+    30    50    30  -760    /* UA,UG,U,A,C */+  -310   -50  -310 -1100    /* UA,UG,U,A,G */+    30    50    30  -760    /* UA,UG,U,A,U */+    30    50    30  -760    /* UA,UG,U,C,A */+    30    50    30  -760    /* UA,UG,U,C,C */+    30    50    30  -760    /* UA,UG,U,C,G */+    30    50    30  -760    /* UA,UG,U,C,U */+  -480  -220  -480 -1270    /* UA,UG,U,G,A */+    30    50    30  -760    /* UA,UG,U,G,C */+  1280  1300  1280  -760    /* UA,UG,U,G,G */+    30    50    30  -760    /* UA,UG,U,G,U */+    30    50    30  -760    /* UA,UG,U,U,A */+    30    50    30  -760    /* UA,UG,U,U,C */+    30    50    30  -760    /* UA,UG,U,U,G */+    30    50    30  -760    /* UA,UG,U,U,U */+  1400  1270  -300  1270    /* UA,AU,A,A,A */+  1090   960  -610   960    /* UA,AU,A,A,C */+    10  -110 -1690  -110    /* UA,AU,A,A,G */+  1090   960  -610   960    /* UA,AU,A,A,U */+  1110   980  -590   980    /* UA,AU,A,C,A */+  1100   970  -360   970    /* UA,AU,A,C,C */+  1110   980  -590   980    /* UA,AU,A,C,G */+  1100   970  -360   970    /* UA,AU,A,C,U */+   190    60 -1510    60    /* UA,AU,A,G,A */+  1090   960  -610   960    /* UA,AU,A,G,C */+  1930  1800 -1020  1800    /* UA,AU,A,G,G */+  1090   960  -610   960    /* UA,AU,A,G,U */+  1110   980  -590   980    /* UA,AU,A,U,A */+  1100   970  -360   970    /* UA,AU,A,U,C */+  1110   980  -590   980    /* UA,AU,A,U,G */+   360     0 -1580     0    /* UA,AU,A,U,U */+  1120  1270  1120   830    /* UA,AU,C,A,A */+   810   960   810   520    /* UA,AU,C,A,C */+  -260   130  -260  -310    /* UA,AU,C,A,G */+   810   960   810   520    /* UA,AU,C,A,U */+   830   980   830   540    /* UA,AU,C,C,A */+   820   970   820   530    /* UA,AU,C,C,C */+   830   980   830   540    /* UA,AU,C,C,G */+   820   970   820   530    /* UA,AU,C,C,U */+   -80   300   -80  -130    /* UA,AU,C,G,A */+   810   960   810   520    /* UA,AU,C,G,C */+  1650  1800  1650  1360    /* UA,AU,C,G,G */+   810   960   810   520    /* UA,AU,C,G,U */+   830   980   830   540    /* UA,AU,C,U,A */+   820   970   820   530    /* UA,AU,C,U,C */+   830   980   830   540    /* UA,AU,C,U,G */+  -150     0  -150  -440    /* UA,AU,C,U,U */+     0  1270  2050  1270    /* UA,AU,G,A,A */+  -310   960  1740   960    /* UA,AU,G,A,C */+ -1390  -110  -580  -110    /* UA,AU,G,A,G */+  -310   960  1740   960    /* UA,AU,G,A,U */+  -290   980  1760   980    /* UA,AU,G,C,A */+   -60   970  1750   970    /* UA,AU,G,C,C */+  -290   980  1760   980    /* UA,AU,G,C,G */+   -60   970  1750   970    /* UA,AU,G,C,U */+ -1210    60  -400    60    /* UA,AU,G,G,A */+  -310   960  1740   960    /* UA,AU,G,G,C */+  -720  1800    80  1800    /* UA,AU,G,G,G */+  -310   960  1740   960    /* UA,AU,G,G,U */+  -290   980  1760   980    /* UA,AU,G,U,A */+   -60   970  1750   970    /* UA,AU,G,U,C */+  -290   980  1760   980    /* UA,AU,G,U,G */+ -1280     0  -470     0    /* UA,AU,G,U,U */+  1120  1140  1120   570    /* UA,AU,U,A,A */+   810   830   810    20    /* UA,AU,U,A,C */+  -260     0  -260 -1050    /* UA,AU,U,A,G */+   810   830   810    20    /* UA,AU,U,A,U */+   830   850   830    40    /* UA,AU,U,C,A */+   820   840   820    30    /* UA,AU,U,C,C */+   830   850   830    40    /* UA,AU,U,C,G */+   820   840   820    30    /* UA,AU,U,C,U */+   -80   180   -80  -870    /* UA,AU,U,G,A */+   810   830   810    20    /* UA,AU,U,G,C */+  1650  1670  1650  -380    /* UA,AU,U,G,G */+   810   830   810    20    /* UA,AU,U,G,U */+   830   850   830    40    /* UA,AU,U,U,A */+   820   840   820    30    /* UA,AU,U,U,C */+   830   850   830    40    /* UA,AU,U,U,G */+  -150  -130  -150  -940    /* UA,AU,U,U,U */+  1470  1340  -230  1340    /* UA,UA,A,A,A */+  1190  1060  -510  1060    /* UA,UA,A,A,C */+    60   -60 -1640   -60    /* UA,UA,A,A,G */+  1190  1060  -510  1060    /* UA,UA,A,A,U */+  1340  1210  -360  1210    /* UA,UA,A,C,A */+  1340  1210  -120  1210    /* UA,UA,A,C,C */+  1340  1210  -360  1210    /* UA,UA,A,C,G */+  1210  1080  -250  1080    /* UA,UA,A,C,U */+  -230  -360 -1940  -360    /* UA,UA,A,G,A */+  1190  1060  -510  1060    /* UA,UA,A,G,C */+  2120  1990  -830  1990    /* UA,UA,A,G,G */+  1190  1060  -510  1060    /* UA,UA,A,G,U */+  1340  1210  -360  1210    /* UA,UA,A,U,A */+   900   770  -560   770    /* UA,UA,A,U,C */+  1340  1210  -360  1210    /* UA,UA,A,U,G */+   640   270 -1300   270    /* UA,UA,A,U,U */+  1190  1340  1190   900    /* UA,UA,C,A,A */+   910  1060   910   620    /* UA,UA,C,A,C */+  -210   180  -210  -260    /* UA,UA,C,A,G */+   910  1060   910   620    /* UA,UA,C,A,U */+  1060  1210  1060   770    /* UA,UA,C,C,A */+  1060  1210  1060   770    /* UA,UA,C,C,C */+  1060  1210  1060   770    /* UA,UA,C,C,G */+   930  1080   930   640    /* UA,UA,C,C,U */+  -510  -120  -510  -560    /* UA,UA,C,G,A */+   910  1060   910   620    /* UA,UA,C,G,C */+  1840  1990  1840  1550    /* UA,UA,C,G,G */+   910  1060   910   620    /* UA,UA,C,G,U */+  1060  1210  1060   770    /* UA,UA,C,U,A */+   620   770   620   330    /* UA,UA,C,U,C */+  1060  1210  1060   770    /* UA,UA,C,U,G */+   120   270   120  -170    /* UA,UA,C,U,U */+    60  1340  2120  1340    /* UA,UA,G,A,A */+  -210  1060  1840  1060    /* UA,UA,G,A,C */+ -1340   -60  -530   -60    /* UA,UA,G,A,G */+  -210  1060  1840  1060    /* UA,UA,G,A,U */+   -60  1210  1990  1210    /* UA,UA,G,C,A */+   180  1210  1990  1210    /* UA,UA,G,C,C */+   -60  1210  1990  1210    /* UA,UA,G,C,G */+    50  1080  1860  1080    /* UA,UA,G,C,U */+ -1640  -360  -830  -360    /* UA,UA,G,G,A */+  -210  1060  1840  1060    /* UA,UA,G,G,C */+  -530  1990   270  1990    /* UA,UA,G,G,G */+  -210  1060  1840  1060    /* UA,UA,G,G,U */+   -60  1210  1990  1210    /* UA,UA,G,U,A */+  -260   770  1550   770    /* UA,UA,G,U,C */+   -60  1210  1990  1210    /* UA,UA,G,U,G */+ -1000   270  -200   270    /* UA,UA,G,U,U */+  1190  1210  1190   640    /* UA,UA,U,A,A */+   910   930   910   120    /* UA,UA,U,A,C */+  -210    50  -210 -1000    /* UA,UA,U,A,G */+   910   930   910   120    /* UA,UA,U,A,U */+  1060  1080  1060   270    /* UA,UA,U,C,A */+  1060  1080  1060   270    /* UA,UA,U,C,C */+  1060  1080  1060   270    /* UA,UA,U,C,G */+   930   950   930   140    /* UA,UA,U,C,U */+  -510  -250  -510 -1300    /* UA,UA,U,G,A */+   910   930   910   120    /* UA,UA,U,G,C */+  1840  1860  1840  -200    /* UA,UA,U,G,G */+   910   930   910   120    /* UA,UA,U,G,U */+  1060  1080  1060   270    /* UA,UA,U,U,A */+   620   640   620  -170    /* UA,UA,U,U,C */+  1060  1080  1060   270    /* UA,UA,U,U,G */+   120   140   120  -670    /* UA,UA,U,U,U */++# hairpin+   INF   INF   INF   540   560   570   540   600   550   640+   650   660   670   680   690   690   700   710   710   720+   720   730   730   740   740   750   750   750   760   760+   770++# hairpin_enthalpies+   INF   INF   INF   130   480   360  -290   130  -290   500+   500   500   500   500   500   500   500   500   500   500+   500   500   500   500   500   500   500   500   500   500+   500++# bulge+   INF   380   280   320   360   400   440   460   470   480+   490   500   510   520   530   540   540   550   550   560+   570   570   580   580   580   590   590   600   600   600+   610++# bulge_enthalpies+   INF  1060   710   710   710   710   710   710   710   710+   710   710   710   710   710   710   710   710   710   710+   710   710   710   710   710   710   710   710   710   710+   710++# interior+   INF   INF   INF   INF   110   200   200   210   230   240+   250   260   270   280   290   290   300   310   310   320+   330   330   340   340   350   350   350   360   360   370+   370++# interior_enthalpies+   INF   INF   INF   INF  -720  -680  -130  -130  -130  -130+  -130  -130  -130  -130  -130  -130  -130  -130  -130  -130+  -130  -130  -130  -130  -130  -130  -130  -130  -130  -130+  -130++# ML_params+      0       0     930    3000     -90    -220++# NINIO+     60     320     300++# Misc+     410     360      50     370++# Triloops+CAACG     680    2370+GUUAC     690    1080++# Tetraloops+CAACGG     550     690+CCAAGG     330   -1030+CCACGG     370    -330+CCCAGG     340    -890+CCGAGG     350    -660+CCGCGG     360    -750+CCUAGG     370    -350+CCUCGG     250   -1390+CUAAGG     360    -760+CUACGG     280   -1070+CUCAGG     370    -660+CUCCGG     270   -1290+CUGCGG     280   -1070+CUUAGG     350    -620+CUUCGG     370   -1530+CUUUGG     370    -680++# Hexaloops+ACAGUACU     280   -1680+ACAGUGAU     360   -1140+ACAGUGCU     290   -1280+ACAGUGUU     180   -1540+++#END